Patent application title: Novel apolipoprotein gene involved in lipid metabolism
Inventors:
Edward Rubin (Berkeley, CA, US)
Len A. Pennacchio (Sebastopol, CA, US)
Assignees:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
IPC8 Class: AA61K3817FI
USPC Class:
514 12
Class name: Designated organic active ingredient containing (doai) peptide containing (e.g., protein, peptones, fibrinogen, etc.) doai 25 or more peptide repeating units in known peptide chain structure
Publication date: 2009-07-16
Patent application number: 20090181884
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Patent application title: Novel apolipoprotein gene involved in lipid metabolism
Inventors:
Edward Rubin
Len A. Pennacchio
Agents:
TOWNSEND AND TOWNSEND AND CREW, LLP
Assignees:
The Regents of the University of California
Origin: SAN FRANCISCO, CA US
IPC8 Class: AA61K3817FI
USPC Class:
514 12
Abstract:
Methods and materials for studying the effects of a newly identified human
gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the
genes are given, and transgenic animals which either contain the gene or
have the endogenous gene knocked out are described. In addition, single
nucleotide polymorphisms (SNPs) in the gene are described and
characterized. It is demonstrated that certain SNPs are associated with
diseases involving lipids and triglycerides and other metabolic diseases.
These SNPs may be used alone or with SNPs from other genes to study
individual risk factors. Methods for intervention in lipid diseases,
including the screening of drugs to treat lipid-related or diabetic
diseases are also disclosed.Claims:
1. An isolated APOAV polypeptide having the amino acid sequence set forth
in SEQ ID NO: 7.
2. A composition for lowering plasma triglycerides comprising a polypeptide having at least 70% homology to the polypeptide of claim 12 and a pharmaceutically acceptable excipient.
3. An antibody that specifically binds to a polypeptide according to claim 12.
4. The antibody of claim 3, wherein the antibody specifically binds to an epitope comprising position 19 of SEQ ID NO:7.
5. A polynucleotide encoding the polypeptide according to claim 1.
6. The composition of claim 2, wherein the polypeptide has at least 95% homology to the polypeptide of claim 12.
Description:
CROSS-REFERENCES TO PRIOR APPLICATION
[0001]This application is a divisional of U.S. patent application Ser. No. 10/229,834, filed Aug. 27, 2002 which claims priority to Application No. 60/315,210, which was filed on Aug. 27, 2001, the disclosure of which are hereby incorporated by reference in their entirety for all purposes.
REFERENCE TO SEQUENCE LISTING
[0003]Applicants assert that the paper copy of the Sequence Listing is identical to the Sequence Listing in computer readable form found on the accompanying computer disk. Applicants incorporate the contents of the sequence listing by reference in its entirety.
BACKGROUND OF THE INVENTION
[0004]1. Field of the Invention
[0005]This invention generally relates to human lipid metabolism, particularly to apolipoproteins, genes encoding these apolipoproteins, related proteins, and their mutations and polymorphisms as they relate to cardiovascular, coronary and other diseases.
[0006]2. Description of the Related Art
[0007]Cardiovascular diseases are the number one cause of death in Western societies. Studies repeatedly show that individuals with high levels of very low-density lipoprotein, (VLDL) and/or low levels of high density lipoprotein (HDL) have significantly increased chances of developing cardiovascular disease. It has been established that strategies to reverse the levels of these lipoprotein particles will lower disease risk in susceptible individuals.
[0008]Lipoproteins function as transport vehicles for triacylglycerols (triglycerides), cholesterol and other lipids. These complexes solubilize highly hydrophobic lipids, and regulate entry and exit of particular lipids at specific targets. Lipoproteins form micelle-like particles that consist of a nonpolar core of triacylglycerols, more commonly known as triglycerides, and cholesteryl esters surrounded by a coating of protein, phospholipids, and cholesterol. The lipoproteins are classified according to density. Lipoprotein particles are composed of lipids and proteins and are such particles as chylomicrons, very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL). (Voet and Voet, Biochemistry, 1990; Stryer, Biochemistry, 1995). The protein components of lipoproteins are known as apolipoproteins.
[0009]Van der Vliet, H N et al., report on a gene that shares homology to APOAV and note its increase in expression following rat liver hepatectomy in J Biol Chem. 2001 Nov. 30; 276(48):44512-20. The rat (GenBank Accession Nos. AF202888 and AF202887), mouse (GenBank Accessions No. AF327059) and human (GenBank Accessions Nos. AF202890 and AF202889) versions of these sequences were deposited in GenBank and entitled, Regeneration-associated protein 3 (Rap 3) mRNA, complete cds. Rap3 is noted in GenBank as an "apolipoprotein-like serum protein; concentration elevated after a 70% partial hepatectomy" in rats.
[0010]The human genomic region containing the DNA sequence for APOAV was sequenced by the Human Genome Project and deposited in GenBanK under Accession Numbers AC007707 and/or AC074203. These deposits cover approximately 200 kb of human genomic DNA. The deposits are associated with clustered 11q23 and 22q11 breakpoints, but no coding regions are described. Computational analyses indicate the previously described APOA-I, APOC-III, and APOA-IV are contained within this interval.
[0011]The GenBank Accession Number AC007707 sequence shows the opposite strand (reverse complement) of the sequences of the present invention. The reverse complement of AC007707 was used as the starting point of the present invention for finding the APOAV gene and coding sequence.
[0012]Yen et al., in PCT Publication WO 01/007803, entitled "Apolipoprotein A-IV-related protein: Polypeptide, polynucleotide sequences and bi-allelic markers thereof" describe a gene corresponding to the present APOAV. The gene is described as encoding an apolipoprotein A-IV-related protein (AA4RP) as well as regulatory sequences at the 5' and 3'end. Also disclosed are biallelic markers of the AA4RP gene useful in genetic analysis. However, Yen et al. describe their biallelic markers differently than the SNP's of the present invention. They disclose no description of any known linkages between these markers and any known disease phenotype.
[0013]Several human cDNA sequences derived from the APOAV gene have been previously disclosed in GenBank. A sequence file generated by the NCBI annotation project in July 2001 (transcript version 1) is disclosed as human mRNA/cDNA sequence, XM--052110. A second sequence file generated by the NCBI annotation project identifies in July 2001 (transcript version 2) can be found as XM--052109. AF202890 (called RAP3) is a third cDNA sequence that is related to the van der Vliet et al. Human ortholog of rat liver regeneration associated protein (transcript version 1). AF202889 (called RAP3) is the fourth cDNA sequence related to the van der Vliet et all. No. AF401201 and was made public on 7 Oct. 2001.
[0014]Other related sequences include mouse mRNA/cDNA sequence (AF327059), called RAP3, which is the sequence identified as the mouse ortholog of rat liver regeneration associated protein. Three publicly generated mouse full-length cDNAs for apoAV are found under the following Accession Nos.: AK004903 (transcript version 2), BC011198 (transcript version 2), and AK004936 human ortholog of rat liver regeneration associated protein (transcript version 2).
[0015]Human protein sequences were predicted from mRNA sequences AF202890 and AF202889 and called AAF25662 and AAF25661, which correspond to the APOAV protein, which can be found under NP--443200 in NCBI.
[0016]The mouse genomic region (which includes additional genes sequenced and used to create the knock-out mice described herein) is SEQ ID NO: 7 in this application. This sequence was deposited in GenBank under GenBank Accession (transcript version 1). The mouse RAP3 protein (GenBank Accession No. AAG49600) is the protein sequence predicted from mRNA sequence AF327059.
BRIEF SUMMARY OF THE INVENTION
[0017]The present invention involves a human apolipoprotein gene and its expressed product, Apolipoprotein A-V (herein referred to as "APOAV" or "APOA5"), located near a previously described apolipoprotein AI/CIII/AIV gene cluster (a region repeatedly implicated in various cardiovascular diseases) and its association with elevated levels of triglycerides.
[0018]The various aspects of the invention, as described below, are useful in the genetic analysis of cardiovascular disease. Patients with genetic predispositions to certain conditions may be screened with the analyses provided herein. High levels of APOAV protein expression are associated with lowered triglyceride levels, and low levels of APOAV expression (as demonstrated in "knock-out mice") are associated with increased levels of triglycerides. Furthermore, various polymorphisms have been identified which are correlated with different plasma triglyceride levels. Specifically, individuals with minor alleles for several SNPs near APOAV consistently display increased plasma triglyceride levels.
[0019]In addition, the present invention involves identification of a strong association between uncommon alleles of SNPs in the APOAV gene and increased plasma triglyceride levels in the general human population. Thus the present invention enables genetic testing for APOAV variants and their correlation to increased triglyceride levels in people having APOAV polymorphisms deviating from the normal or "wild type" phenotype. Further, a combination test APOCIII is suggested. Genetic testing may be carried out on a patient's DNA or RNA or protein, provided that antibodies capable of distinguishing mutant from wild type APOAV protein are available. Furthermore, genetic testing using the markers disclosed herein may be used to identify individuals at risk for diabetes and/or insulin resistance. Genetic testing may also be used to determine an individuals' susceptibility to Familial hypercholesterolemia or other forms of hypercholesterolemia.
[0020]The invention also provides means for identifying haplotypes that are linked to the diseases of hyperlipidemia (CHL) and familial combined hyerlipidemia (FCHL).
[0021]Association studies indicate the existence of three haplotypes (APOA5*1, APOA5*2, APOA5*3) in APOA present in the general human population, that are associated with triglycerides. These three haplotypes are composed of five biallelic markers (SNPs 1-3, 5, and 6).
[0022]Thus, the invention includes using various methods for screening for genetic APOAV haplotypes or SNPs in humans. Fragments of various lengths of APOAV SEQ ID NOS: 1-7 may be placed onto solid supports for use in gene chips or other parallel formats for assay purposes. The sequences used will span a SNP and have sufficient flanking bases for specificity and binding, e.g. 10 bases on either side (5' and 3') of the nucleotide bearing the SNP. As few as 2 and as many as 1,000 bases may be used, depending on test design considerations.
[0023]Other methods for diagnostic purposes in this invention include but are not limited to, making antibodies to APOAV and its variants, attachment of the APOAV sequences disclosed herein onto solid supports for array and gene chips, and other hybridization assays.
[0024]The invention provides non-human animals that over-express the human version of APOAV. The over-expression of this gene results in these animals having dramatically reduced plasma triglyceride levels (˜3-fold). In addition to decreased triglyceride levels these mice also have corresponding decreases in VLDL levels.
[0025]The invention also provides homozygous knockout non-human animals that are lacking apoA5 and therefore do not produce apoA5 protein. These animals have increased and VLDL and triglyceride levels. This invention also includes recombinant vectors and DNA targeting constructs, such as the one used by the inventors to delete mouse apoA5 and was built using PCR products and primers made from SEQ ID NO: 7.
[0026]This invention also provides non-human animals for further animal studies by pharmaceutical companies to study human or mouse apoA5. Animal studies that explore the regulation and expression of human or mouse apoA5, its interaction with other apolipoproteins, production of antibodies for mutant and wild-type apoA5, and further in vivo study of apoA5. For example, mice lacking wild-type apoA5 may be exposed to various test substances to determine the triglyceride lowering effect of the test substance on individuals having a non-wild-type apoAV gene. The invention provides non-human animals useful for studying apoCIII since its levels are altered in these mouse models.
[0027]The invention can be further characterized as including an isolated polypeptide wild type APOAV protein as set forth in SEQ ID NO: 4, which corresponds to the ideal normal APOA5*1 haplotype. One mutant protein is encoded by DNA carrying the uncommon SNP5, described below as variation SNP5 at position 12974 is set forth in SEQ ID NO: 3 and corresponds to haplotype APOA5*3.
[0028]Another aspect of the invention is that stratification of populations based on APOA5 markers may identify a subset of individuals that respond differently to current and future drug therapies. These studies would contribute in understanding which of these drug therapies or combinations of drug therapies are the most beneficial to lower triglyceride levels in individuals having haplotypes APOA5*1, APOA5*2 or APOA5*3.
[0029]The SNPs disclosed herein can also be studied for association with other diseases including, but not limited to, diabetes, obesity, metabolic syndrome, or other generic disorders. The inter-relatedness of these conditions is well established in the literature. APOA5-increased expression or other means for protein delivery may prove to be successful to treat numerous symptoms of these diseases.
[0030]This invention also provides the means of combination therapy which uses high levels of APOAV expression or protein regardless of genotype or haplotype to treat any condition of high triglycerides. This strategy could also be combined with stratification-based studies. A further aspect of the invention is gene therapy to deliver active drugs to liver cells to over-express APOAV and thereby decrease triglycerides. Delivery of APOAV therapies can be by such methods as but not limited to, injection of active APOAV, delivery by pill form, and inhalation by spray to deliver APOAV to lungs and the blood to reduce triglycerides.
[0031]The inventions also encompasses drug screening and design of therapeutic agents to be used in methods for increasing APOAV expression, and thereby lowering triglycerides, based on the APOAV polynucleotides and polypeptides described herein is also an important aspect of the invention, especially in the identification of genes, regulatory elements, ligands, drugs and other therapeutic agents to be used to modulate and regulate APOAV expression. Such therapeutic agents include current drug therapies for high triglyceride levels such as fibrates or other drug agents which are known to reduce triglycerides.
BRIEF DESCRIPTION OF THE DRAWINGS
[0032]FIG. 1. A diagram showing the genomic organization of the human APOAI/CIII/AIV cluster (1a) and VISTA plot showing similarities between the mouse and human sequences in this region.
[0033]FIG. 2. A diagram of the targeting construct used to generate apoA5-deficient mice. Homology arms were designed to delete the coding exons of the gene (depicted by black boxes).
[0034]FIG. 3. Bar charts showing plasma triglyceride and cholesterol for human transgenic (FIG. 3A) mice and apoAV knockout mice (FIG. 3B).
[0035]FIG. 4. (A) New SNP map of the APOAV genomic locus. Exons are depicted by rectangles with coding sequence filled in with black and untranslated regions with white. The gene is transcribed in the right to left direction. (B) Minor allele frequencies are approximately 10% in Caucasians for SNPs 1, 2, 3, 5, 6, and ˜40% for SNP4. Minor alleles for SNPs 1, 2, 3, and 6 form a common haplotype (˜10%). SNP5 is part of a second independent haplotype (˜10%).
[0036]FIG. 5. Table of genotyping data from 501 individuals (A); pair-wise measures of linkage disequilibrium (B); and SNP3 genotyping data from a different set of individuals stratified by triglyceride levels (C).
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
Definitions
[0037]The term "triglycerides" is used in its ordinary medical sense. However, the tests of the present invention for disposition towards elevated triglyceride levels may also include elevated triacylglycerol, cholesterol, and other related lipid levels, very low density lipoprotein (VLDL) levels, or levels of other closely related apolipoproteins or lipoprotein particles such as chylomicrons, intermediate density lipoprotein (IDL), or low density lipoprotein (LDL) or high density lipoprotein (HDL) levels.
[0038]"Single nucleotide polymorphisms" (SNPs), which are defined in relation to a population, are variations in DNA at a single base that are found in at least 1% of the population. The terms "biallelic marker," "marker," "polymorphism" and "allele" are also used to denote variations at a single base and are used interchangeably.
[0039]The term, "genotype," is used herein to mean a specific allele or alleles an individual carries at a given locus. It can also be used to describe a set of alleles for multiple loci.
[0040]A "haplotype" is a set of alleles for closely spaced polymorphisms along a chromosome that tend to be inherited together. Alternatively a haplotype can be thought of as a combination of alleles of closely linked loci that are found in a single chromosomal interval and tend to be inherited together. An individual SNP allele can be used to define a given haplotype.
[0041]The term "phenotype," is used herein to mean the form taken by some character (or group of characters) in a specific individual. It can also mean the detectable outward manifestations of a specific genotype.
[0042]The term, "proband" is used to mean an affected individual in a family.
[0043]The term, "allele" is used herein to mean one of the different forms of a gene that can exist at a single locus. An allele is also used to describe a given version of a polymorphism.
[0044]The term, "allele frequency" is used to mean a measure of the commonness of an allele in a population, the proportion of all alleles of that gene or polymorphism in the population that are of this specific type.
[0045]The term, "Hardy-Weinberg" is used to refer to calculating the Hardy-Weinberg equilibrium for genotypes, whereby the stable frequency distribution of genotypes AA, Aa, and aa, in the proportions p2, 2pq and q2, respectively (where p and q are the frequencies of the alleles A and a), that is a consequence of random mating in the absence of mutation, migration, natural selection or random drift.
[0046]The term "P-value" is used herein to mean the probability that the results were not significant. For example, a p-value of 0.05 means that there are 5 chances in 100 that the results are not significant.
[0047]The term, "SEM" is used to mean the standard of the mean.
[0048]The term "linkage disequilibrium" is used herein to refer to the relationship that is said to exist between a allele found at a single polymorphic site and alleles found at nearby polymorphisms if the presence of one allele is strongly predictive of the alleles present at the nearby polymorphic sites. Thus, the existence of linkage disequilibrium (LD) enables an allele of one polymorphic marker to be used as a surrogate for a specific allele of another.
[0049]"Substantial homology or similarity" means that a nucleic acid or fragment thereof is "substantially homologous" (or "substantially similar") to another if, when optimally aligned (with appropriate nucleotide insertions or deletions) with the other nucleic acid (or its complementary strand), using BLASTN there is nucleotide sequence identity in at least about 60% of the nucleotide bases, usually at least about 70%, more usually at least about 80%, preferably at least about 90%, and more preferably at least about 95-98% of the nucleotide bases. To determine homology between two different nucleic acids, the percent homology is to be determined using the BLASTN program "BLAST 2 sequences". This program is available for public use from the National Center for Biotechnology Information (NCBI) over the Internet (Altschul et al., 1997). The parameters to be used are whatever combination of the following yields the highest calculated percent homology (as calculated below) with the default parameters shown in parentheses: [0050]Program--blastn [0051]Matrix--0 BLOSUM62 [0052]Reward for a match--0 or 1 (1) [0053]Penalty for a mismatch--0, -1, -2 or -3 (-2) [0054]Open gap penalty--0, 1, 2, 3, 4 or 5 (5) [0055]Extension gap penalty--0 or 1 (1) [0056]Gap x_dropoff--0 or 50 (50) [0057]Expect--10
[0058]The terms "substantial homology" or "substantial identity", when referring to polypeptides, indicate that the polypeptide or protein in question exhibits at least about 30% identity using BLASTP with an entire naturally-occurring protein or a portion thereof, usually at least about 70% identity over the common lengths, more usually at least about 80% identity, preferably at least about 90% identity, and more preferably at least about 95% identity.
[0059]Homology, for polypeptides, is typically measured using sequence analysis software. See, e.g., the Sequence Analysis Software Package of the Genetics Computer Group, University of Wisconsin Biotechnology Center, 910 University Avenue, Madison, Wis. 53705. Protein analysis software matches similar sequences using measures of homology assigned to various substitutions, deletions and other modifications. Conservative substitutions typically include substitutions within the following groups: glycine, alanine; valine, isoleucine, leucine; aspartic acid, glutamic acid; asparagine, glutamine; serine, threonine; lysine, arginine; and phenylalanine, tyrosine.
[0060]The term "polynucleotide" refers to a chain of nucleotides without regard to length of the chain.
[0061]The term "polypeptide" refers to a polymer of amino acids without regard to the length of the polymer; thus, peptides, oligopeptides, and proteins are included in this term.
[0062]A. Sequences of Apolipoprotein A-V
[0063]Despite the previous availability of sequence in the human apoAI/CIII/AIV genomic interval, the gene APOAV was characterized by human/mouse sequence comparison, using the power of comparative sequence analysis to prioritize potential functional regions of the genome. APOAV represents a fourth member of the clinically important apolipoprotein gene cluster on human 11q23. The human and mouse data, both when taken independently and combined, indicate an important role for APOAV in plasma triglyceride homeostasis. While previous data have associated the apoCIII locus with extremely high plasma triglyceride levels in humans, the results of the present studies suggest the possible use of APOAV polymorphisms as prognostic indicators for hyper-triglyceridemia susceptibility and the focus on APOAV modulation as a potential strategy to reduce this known cardiovascular disease risk factor.
[0064]FIG. 1 shows human and mouse comparative sequence analysis of the apoAI/CIII/AIV gene cluster. (A) A schematic of the genomic organization of human APOAV and the relative SNP positions (arrows). APOAV exons are shown with solid boxes and the distance between each SNP is indicated above the line. The predicted transcription start site is depicted by a bent arrow and the relative position of the promoter, and start and stop codons are shown. (B) In each panel 30 kbp of contiguous human sequence is illustrated horizontally. Above each panel arrows correspond to known genes and their orientation with each exon depicted by a box (gene names are indicated above each arrow). The VISTA (VISualization Tools for Alignment) plot displays the level of homology between human and the orthologous mouse sequence. Human sequence is represented on the x-axis and the percent similarity with the mouse sequence is plotted on the y-axis (ranging from 50-100% identity).
[0065]A preferred embodiment involves a human apolipoprotein gene, APOAV, located near a previously described apolipoprotein AI/CIII/AIV gene cluster (a region repeatedly implicated in various cardiovascular diseases). Electronic homology searches with human apoAI, apoCIII, and apoAIV mRNA sequences using the BLAST algorithm (S. F. Altschul, W. Gish, W. Miller, E. W. Myers, D. J. Lipman, J Mol. Biol 215, 403-10 (1990)) identified a genomic bacterial artificial chromosome (BAC) clone containing the complete apoAI/CIII/AIV gene cluster (GenBank Accession No. AC007707).
[0066]The predicted 368-amino acid sequence shows significant homology to various known apolipoproteins, with the strongest similarity to mouse apoAIV (24% identity and 49% similarity). Examination of the orthologous human genomic sequence indicates a similar genomic structure to the mouse region and predicts an open reading frame encoding a 366-amino acid protein with high sequence homology to mouse apoAV (71% identity and 78% similarity), as well as human apoAIV (27% identity, 48% similarity). Protein structure analyses predicts several amphipathic helical domains and an N-terminal signal peptide in both human and mouse APOAV, which are characteristic features of lipid-binding apolipoproteins.
[0067]Transcripts approximately 1.3- and 1.9-kilobases (kb) in length were identified predominantly in liver tissue from both species by Northern blots analysis, where mRNA from several different human and mouse tissues was hybridized with APOAV cDNA probes from human and mouse, respectively. The full-length sequences of mouse cDNAs indicate the two transcripts in mice are likely the result of alternative polyadenylation. The mouse apoA5 cDNA sequences are available under GenBank Accession Nos. AK004936 and AK004903.
[0068](1) Brief Description of the Sequences (SEQ ID NOS: 1-48)
[0069]SEQ ID NO: 1 and 2 are cDNA sequences corresponding to the coding sequence of a "wild type" APOAV gene and are deposited in GenBank under Accession No. AF202889.1 and F202890.1. Both cDNAs contain the normal wild type alleles. SEQ ID NO: 1 is a 1.3 kb transcript of the APOAV gene. SEQ ID NO: 2 is an alternatively spliced 1.8 kb transcript of the APOAV gene. The protein is encoded on the reverse complement. SNP5 is the only SNP in the group that changes an amino acid (Serine (S 19)→Tryptophan (W19)) at position 19 of the putative protein. The substitution of G for A in SNP6 is in a critical nucleotide of the Kozak consensus sequence (-3 bp).
[0070]SEQ ID NO: 3 is the human genomic sequence comprising the present wild type APOAV gene, certain of its regulatory elements, and the SNPs associated with the genomic sequence. The indicated SNPs are numbered as follows: SNP 4, 3, 6, 5, 2, 1 in the order in which they appear in the sequence. The following table indicates the base pair positions in SEQ ID NO: 3 where these polymorphisms are found. Profiles for each of these SNPs can be found in GenBank under the following Accession Numbers: 2266788 (SNP1), 2072560 (SNP2), 662799 (SNP3), 3199916 (SNP4), 3135506 (SNP5), 651821 (SNP6) and 3135507 (V153M).
TABLE-US-00001 TABLE 1 SNPs shown in SEQ ID NO: 3 SNP Position Number Original allele > number in SEQ ID NO: 3 Rare allele Location in APOA5 4 567 T > C Between APOA5 and APOA4 3 11674 T > C Upstream 6 12802 A > G 5' untranslated region 5 12974 C > G causing an amino acid change in the APOA5 gene product (S19 → W19) 2 13555 G > A Intervening sequence 3 + 476 1 14695 T > C Coding sequence 1259
[0071]SEQ ID NO: 3 and 4 are annotated to show certain regulatory regions (CAAT box and TATAA box); the exons; and start and stop codons and the untranslated regions.
[0072]SEQ ID NO: 4 is the ideal wild type genomic sequence of human APOAV gene and contains the alleles in their major form, as do the corresponding GenBank sequences.
[0073]SEQ ID NO: 5 is the human DNA sequence used to create the transgenic mice expressing human APOAV. This sequence has not been deposited in GenBank.
[0074]SEQ ID NO: 6 is the working draft sequence of the mouse apoA5 that was deposited by the inventors in GenBank and recently released for publication to the public. It is the mouse genomic apoA5 region used to generate the homozygous knock-out mice. It consists of 75 unordered and unoriented contigs, wherein the gaps of unknown length are denoted as an `n` in the sequence.
[0075]SEQ ID NO: 7 is the amino acid sequence of the protein product generated from SEQ ID NO: 4. A suitable wild-type APOAV protein is set forth in SEQ ID NO: 7. One mutant protein is encoded by DNA carrying the uncommon SNP5, is set forth in SEQ ID NO: 3.
[0076]SEQ ID NOs: 8-9 are the forward and reverse primers used to isolate mouse genomic DNA in Example 1 from the pooled mouse BAC library.
[0077]SEQ ID NOs: 10-11 are the forward and reverse primers used to genotype transgenic mouse for the human APOAV gene.
[0078]SEQ ID NOs: 12-15 are the PCR primers that were used to build the homology arms in the targeting construct to delete mouse apoA5 in knockout mice.
[0079]SEQ ID NOs: 16-17 were used to amplify the external 3' probe when creating the apoA5 knockout animals.
[0080]SEQ ID NOs: 18-19 and SEQ ID NOs: 37-38 are the primers used to genotype the apoA5 knockout animals. SEQ ID NOS: 18-19 are the forward and reverse primers to genotype for the presence of the apoA5 gene.
[0081]SEQ ID NOs: 20-21 are the forward and reverse primers used to amplify and genotype SNP3.
[0082]SEQ ID NOs: 22-23 are the degenerate primers used to genotype the transgenic animals for the presence of APOAV and to probe PCR amplified liver cDNA for human or mouse APOAV cDNAs.
[0083]SEQ ID NOs: 24-25 are the forward and reverse primers used to genotype SNP5. SEQ ID NOs: 26-27 are the reverse and forward primers used to genotype the V153M polymorphism.
[0084]SEQ ID NOs: 28-36 are the probes and INVADER sequences used to perform the INVADER assays to genotype SNPs 5, 6 and V153M.
[0085]SEQ ID NOs: 37-38 are the forward and reverse primers used to genotype the presence of the neomycin gene in preparing the apoA5 knockout mice.
[0086]SEQ ID NOs: 39-48 are primers used to genotype the six SNPs as shown in Table 3.
[0087]SEQ ID NOs: 39-40 are the forward and reverse primers used to amplify or genotype SNP1.
[0088]SEQ ID NOs: 41-42 are the forward and reverse primers used to amplify or genotype SNP2.
[0089]SEQ ID NOs: 43-44 are the forward and reverse primers used to amplify or genotype SNP5.
[0090]SEQ ID NOs: 45-46 are the forward and reverse primers used to amplify or genotype SNP3 and SNP6.
[0091]SEQ ID NOs: 47-48 are the forward and reverse primers used to amplify or genotype SNP4.
[0092](2) Applications for APOAV Sequences
[0093]In another embodiment, a polynucleotide fragment is also contemplated wherein the fragment comprises a contiguous span of at least 12 nucleotides of SEQ ID NO: 3, where said contiguous span encompasses one or more SNPs 1-3, 5 or 6 as described in SEQ ID NO: 3.
[0094]A further preferred embodiment consists of a purified, isolated, synthesized or recombinant nucleic acid that hybridizes with an SNP nucleotide-containing the nucleotide sequence of SEQ ID NOs: 3 or 5, or a complementary sequence or a variant that is substantially homologous.
[0095]B. APOAV DNA Constructs and Recombinant Vectors
[0096]The present embodiment encompasses a recombinant vector comprising a polynucleotide that is substantially homologous to any of the polynucleotides described herein, including regulatory sequences, coding sequences and polynucleotide constructs, as well as any APOAV primer or probe. In a first preferred embodiment, a recombinant vector comprises expression vectors comprising either a regulatory polynucleotide of APOAV or a coding nucleic acid of the present embodiment, or both. Within some embodiments, the expression vectors are employed in the in vivo expression of APOAV in non-human animals. In other embodiments, the expression vectors are used for constructing transgenic animals and gene therapy.
[0097]Depending on the host organism or cell wherein the APOAV gene will be expressed, one skilled in the art can adapt the recombinant vector to further comprise genetic elements, including but not limited to, an origin of replication in the desired host, suitable promoters and enhancers, any necessary ribosome binding sites, polyadenylation signal, splice donor and acceptor sites, transcriptional termination sequences, selectable markers and non-transcribed flanking sequences. Various types of gene delivery vectors can be used including, but definitely not limited to, plasmids, YACs (Yeast Artificial Chromosomes), BACs (Bacterial Artificial Chromosomes), bacterial vectors, bacteriophage vectors, viral vectors (for example, retroviruses, adenoviruses and viruses commonly used for gene therapy), non-viral synthetic vectors, and recombinant vectors, etc.
[0098]A second embodiment comprises a host cell that has been transformed or transfected with one of the APOAV polynucleotides described herein, in particular a polynucleotide comprising SEQ ID NO: 1, 2 or 5 or a fragment or variant thereof. Appropriate host cells can be prokaryotic host cells, such as E. coli, Bacillus subtilis, Salmonella typhimurium, and strains from species including but not limited to, Pseudomonas, Streptomyces and Staphylococcus. Alternatively eukaryotic host cells can be used, including but not limited to, HeLa cells, HepG2 and other mammalian host cells. A preferred embodiment is a mammalian host cell comprising the APOAV genomic region, wherein the APOAV gene is disrupted by homologous recombination with a knockout vector.
[0099]In order to study the physiological and phenotypic consequences of a lack of synthesis of the APOAV protein, both at the cellular level and at the organism level, the preferred embodiment also encompasses DNA constructs and recombinant vectors enabling conditional expression of a specific allele or haplotype of the APOAV genomic sequence as described in SEQ ID NO: 3, 5 or 6 or an APOAV cDNA (SEQ ID NO: 1, 2) in a transgenic non-human animal. The embodiment also encompasses DNA constructs to generate animals having multiple copies of the APOAV protein expressed and animals having no APOAV protein that is expressed ("knock-out animals").
[0100]The targeting construct can be built by various methods known in the art including but not limited to, PCR primers for integration by homologous recombination, using a represssor/marker promotor construct, Cre-LoxP system, and antisense constructs. The method preferred is using PCR products and primers to build the targeting construct. To build such a construct to make knockout non-human animals and cells, one would need the homology "arms" that flank each side of the sequence to be deleted or disrupted, and a selectable marker inserted between the arms to select for the marker function. The sequence to be deleted can be the whole APOAV gene as the inventors did in Example 3, single or multiple exons, intervening genomic sequences, short peptide sequences and even single base pair deletions. After delivery of the construct into embryonic stem cells, selection for the marker permits gene deletion. Or for instance, APOAV gene function can be disrupted by insertion of the selectable marker, by inserting insertion of the marker in the promoter, splice sites, or the open reading frame.
[0101]To make transgenic non-human animals, designing the construct should include as much flanking sequence of APOAV as to include all the regulatory elements that may be found in the flanking genomic DNA. One needs to consider the neighboring genes and whether or not they should be over-expressed as well. See Thomas, K. R. and Capecchi, M. R., Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503, 1987.
[0102]Thus in a specific embodiment, SEQ ID NO: 5, which is the 26 Kb XhoI isolated polynucleotide of the human APOAV region, can be used to create constructs that includes APOAV and APOAV flanking sequence but does not include neighboring APO genes. In a preferred embodiment, the targeting construct to delete mouse apoAV can be built using PCR products and primers made from SEQ ID NO: 7. For example, apoA5 knockout mice were generated by deleting the three exons predicted to encode apoA5 (FIG. 1A, FIG. 2).
[0103]In order to effect expression of the polynucleotides and polynucleotide constructs preferred embodiment, these constructs must be delivered to the host cell, where once it has been delivered to the cell, it may be stably integrated into the genome of the host cell and effectuate cellular expression. This delivery can be accomplished in vitro, for laboratory procedures for transforming cell lines, or in vivo or ex vivo, for the creation of therapies or treatments of diseases. Mechanisms of delivery include, but are not limited to, viral infection (where the expression construct is encapsulated in an infection viral particle), other non-viral methods known in the art such as, calcium phosphate precipitation, DEAE-dextran, electroporation, direct micro-injection, DNA-loaded liposomes, and receptor-mediated transfection of the expression construct. In a preferred embodiment, the delivery of the construct is by micro-injection into the appropriate host cell or by intravenous injection in the organism.
[0104]C. Correlation of APOAV Sequence Variants with Human Plasma Triglyceride Levels
[0105]Single nucleotide polymorphisms (SNPs) were first identified across and surrounding the human APOAV locus to serve as genetic markers for association. Six markers with relatively high minor allele frequencies (>8%) were obtained. Five of the SNPs were separated by three kbp within APOAV (SNP1-3, 5 and 6), while the fourth SNP (SNP4) was located ˜11 kbp upstream of the gene (FIG. 1A). These markers were scored in approximately 500 random unrelated normo-lipidemic Caucasian individuals who had been phenotyped for numerous lipid parameters before and after consumption of high- and low-fat diets.
[0106]Significant associations were found between both plasma triglyceride levels and VLDL mass and the five neighboring SNPs 1-3, 5 and 6 within APOAV but not with the distant upstream SNP4 (FIGS. 1A, 5A). Specifically, the minor allele of each of these SNPs (SNPs1-3, 5 and 6) was associated with higher triglyceride levels independent of diet. Independent analysis of each of SNPs 1-3, 5 and 6 revealed plasma triglyceride levels were 20-30% higher in individuals having one minor allele compared to individuals homozygous for the major allele (FIG. 4A). Two independent groups of individuals displayed increased triglycerides. First is a group of individuals with minor alleles at SNPs1-3, 6, while the second group of individuals contained the minor allele at SNP5.
[0107]Since the Caucasian population has two different apparent causative chromosomes for increased triglycerides and the allele frequency is ˜8% for both haplotypes, this observation effects a large number of individuals in the general population. (A minor allele frequency of 8% means there is an 8% probability for the rare haplotypes to occur on each chromosome.) Based on Hardy-Weinberg, the expected genotype distributions for such SNPs in the population can be calculated yielding 84.6% homozygous for the major allele, 14.7% heterozygous,
[0108]D. Transgenic Non-Human Animals to Assess Function of APOAV
[0109]The preferred embodiment also provides non-human animals to assess APOAV function. These non-human animals are preferably mammalian, even more preferably from the group consisting of mouse, rat, dog, chimpanzee, orangutan, baboon and macaque. These non-human animals are most preferably of the species Mus musculus, over-expressing human APOAV, as well as mice lacking apoA5 through standard mouse transgenic and gene knockout technologies (FIG. 2) (See K. A. Frazer, G. Narla, J. L. Zhang, E. M. Rubin, Nat Genet 9, 424-31 (1995) and C. Paszty, et al., Nat Genet 11, 33-39 (1995)). apoA5 knock-out animals and transgenic animals exhibit dramatic, but opposite effects on plasma triglyceride levels. apoA5 knockout animals exhibit a hyper-triglyceride phenotype, while the APOAV transgenic animals which over-express APOAV protein, exhibit a hypo-triglyceride phenotype.
[0110]APOAV transgenic animals, depending on the genetic background and the amount of overexpression, should exhibit at least two fold lower levels of plasma triglyceride. Multiple copies of the human APOAV gene result in an observed over-expression of the APOAV gene which can be determined by Northern blot analysis and result in reduced plasma triglyceride levels.
[0111]In addition to decreased triglyceride levels APOAV transgenic non-human animals should also have corresponding decreases in VLDL levels. This finding is consistent with the general knowledge that the majority of plasma triglyceride is carried on VLDL particles. VLDL levels can be characterized by fast protein liquid chromatography of lipoprotein particles from the animals or by other standard methods of lipoprotein determination such as ultracentrifugation.
[0112]An alternate embodiment also provides homozygous knockouts that are lacking apoA5 protein or lacking functional apoA5 protein. Transformed or transgenic cells, cell lines or non-human animals are obtained by homologous recombination of at least one apoA5 exon in embryonic stem cells, transfer of these stem cells to embryos, selection of the chimeras affected at the level of the reproductive lines, and growth of the said chimeras. Following successful germ-line transmission, heterozygous animals are then intercrossed.
[0113]The levels of very low-density lipoprotein (VLDL) particles increase in homozygous knockout animals and decrease in transgenic animals as compared with controls. Heterozygous knockout animals should exhibit VLDL levels intermediate between the homozygous knockout and control mouse. The peak VLDL elution volumes should remain similar in all animals, supporting comparable VLDL particle size, and that levels of other lipoproteins are not significantly altered.
[0114]To generate non-human animals which over-express APOAV, SEQ ID NO: 5, which is a 26.6 kbp XhoI human genomic DNA fragment predicted to contain only human APOAV, can be integrated into the genome of non-human embryos, thereby resulting in the expression of several copies of the human APOAV gene by the non-human animals. In addition, transgenic animals such as rats and rabbits, or transgenic continuous cell lines can be made. Furthermore, transgenic animals can be made using cDNA encoding human APOAV, both in its wild type and variants as described herein.
[0115]Transgenic non-human animals over-expressing the APOAV gene could be obtained by transfection of multiple copies of said APOAV gene under the control of a strong promoter of an ubiquitous nature, or promoters selective for a type of tissue, preferably liver tissue.
[0116]This embodiment also provides non-human animals for further animal studies by pharmaceutical companies to study APOAV. Animal studies that explore the regulation and expression of APOAV, its interaction with other apolipoproteins or other plasma, membrane or cellular proteins, production of antibodies for mutant and wild-type apoA5, and further in vivo study of apoA5. For example, mice lacking wild-type apoA5 may be exposed to various test substances to determine the triglyceride lowering effect of the test substance on individuals having a non-wild-type apoA5 gene. If a certain drug is no longer able to work, it would indicate that apoa5 is needed for the given drug to exert its affect.
[0117]Preferably, said transformed cells or mammals of the preferred embodiment will be used as a model allowing, in particular, the selection of products which make it possible to combat the pathologies induced by high levels of triglycerides.
[0118]In another embodiment, the non-human animals can be used to reveal the mechanism behind how apoA5 exerts its affect. Studies using the non-human animals can enable the elucidation of different mechanisms of triglyceride regulation, including but not limited to, clearance from the liver, secretion, production, catabolism and lipolysis of triglycerides. For example, to study clearance, one can identify a liver receptor or an alteration in the rate of VLDL clearance from the liver that apoA5 works through, which would prove to be a significant future target for drugs. The non-human animals may be used to show how apoA5 works in the liver to move triglycerides from the liver to the plasma, or if it is involved in increased lipolysis in the peripheries, or whether apoA5 has an effect on inflammation that leads to altered triglyceride levels.
[0119]E. Effects on Other Apolipoproteins in Transgenic Non-Human Animals
[0120]The observed changes in plasma triglyceride levels in apoA5 knockout and transgenic animals are directly opposite those previously reported in apoC3 knockout and transgenic mice (Y. Ito et al., Science 249, 790-3 (1990); N. Maeda, et al., J Biol Chem 269, 23610-6 (1994)). The apoA5 knockouts displayed an approximately 400% increase in plasma triglycerides compared to the 30% decrease noted in ApoC3 knockouts, while apoA5 transgenics showed decreased triglyceride levels compared to the increase reported in apoC3 transgenics.
[0121]The transgenic mice over-expressing human APOAV showed a decrease in apoCIII levels thereby suggesting a mechanism behind APOAV's effect on plasma triglyceride levels. Furthermore, mice lacking APOAV have increased apoCIII levels. Whether this direct association is coincidence or causal of the triglyceride phenotype remains to be determined.
[0122]Altered apoA5 expression affects apoC3 protein but not transcript levels in both apoA5 transgenic and knockout animals; apoC3 levels were increased ˜90% in apoA5 knockouts and decreased ˜40% in apoA5 transgenics. These data suggest that apoC3 may exert its effect on triglyceride levels by altering apoA5 levels.
[0123]Because alterations in apoA5 expression lead to changes in apoC3 protein levels, the effect on triglycerides may be mediated through apoC3. The fact that apoA5 transgenic mice have two-fold lower triglycerides than the previously described apoC3 knockout mice indicate that changes in apoC3 alone can not explain the entire effect of apoA5. In addition to APOC3, the over-expression of several human apolipoprotein transgenes has been shown to increase triglyceride levels in mice, while only the APOAV transgene leads to decreased triglycerides suggesting a novel mechanism behind this effect.
[0124]While not being bound to one theory, the inventors theorize that the APOAV gene product (protein) interacts with other proteins in the apo family (e.g. APOC3) in such a way as to affect their levels, and thereby triglyceride levels. The inventors describe a direct correlation between APOAV and APOC3. Thus, this embodiment also provides non-human animals to explore the regulation and expression of apoA5 and apoC3, the interaction between these two apolipoproteins and other apolipoproteins, and further in vivo study of APOC3. APOC3 is known to inhibit triglyceride lipolysis on VLDL, thus contributing to higher levels of plasma triglyceride and VLDL. The transgenic mice over-expressing human APOAV showed a decrease in APOC3 levels thereby suggesting a mechanism behind APOAV's effect on plasma triglyceride levels. Furthermore, mice lacking APOAV have increased APOC3 levels.
[0125]Therefore, the preferred embodiment includes a method for determining predisposition towards elevated triglyceride levels of an individual, comprising determining the level of APOAV gene expression, wherein elevated APOAV gene expression is associated with decreased elevated triglycerides and lowered APOAV gene expression is associated with increased elevated triglycerides. The method further comprising determining the level of APOC3 gene expression, wherein lowered APOC3 gene expression is associated with decreased elevated triglycerides and elevated APOC3 gene expression is associated with increased elevated triglycerides.
[0126]F. APOAV Haplotypes and Frequencies
[0127]The population frequency for each haplotype is the percentage of individuals who have a given haplotype. Statistically, approximately 50-75% of the population is homozygous for the common haplotype (*1/*1) that is correlated with lower triglyceride levels, while approximately 25-50% of the population contains at least one copy of the minor haplotypes (APOA5*2 and/or APOA5*3) which is correlated with increased triglyceride levels. In addition, approximately 0.6-1.5% of the population is homozygous with both chromosomes containing the rare haplotypes (*2/*2, *3/*3 or *2/*3), which is correlated with the highest triglyceride levels.
[0128]Association studies that were conducted indicate the existence of three haplotypes in APOAV present in the human population, which are associated with plasma triglyceride levels. Preliminary studies in this population found no significant association of triglyceride levels with the Sst1 polymorphism in APOC3 (located ˜40 kbp upstream of APOAV) (FIG. 1A) which has been previously associated with severe hyper-triglyceridemia (M. R. Hayden, et al., Am J Hum Genet 40, 421-30 (1987); M. Dammerman, L. A. Sandkuijl, J. L. Halaas, W. Chung, J. L. Breslow, Proc Natl Acad Sci USA 90, 4562-6 (1993). This finding suggests the APOC3 Sst1 polymorphism is not a marker for the metabolic effect defined by the APOAV haplotypes.
[0129]The three haplotypes (APOA5*1, APOA5*2, APOA5*3) are composed of biallelic markers at the following positions on APOAV: -1131T>C (SNP3), c.-3A>G (SNP6), c.56C>G (SNP5), IVS3+476G>A (SNP2) and c.1259>C (SNP1). Table 2 shows the three haplotypes and the relative frequencies that each appears in the Caucasian general population.
TABLE-US-00002 TABLE 2 -1131T > C c.-3A > G c.56C > G IVS3 + 476G > A c.1259T > C Haplotype Frequency (SNP3) (SNP6) (SNP5) (SNP2) (SNP1) APOA5*1 81.6% T A C G T APOA5*2 8.0% C G C A C APOA5*3 8.0% T A G G T
[0130]The frequency listed for each haplotype is the relative frequency per chromosome, meaning that statistically, approximately 75% of the Caucasian population is homozygous for the common haplotype (*1/*1) that is correlated to low triglyceride levels, approximately 25% of the Caucasian population is heterozygous with one chromosome having the common haplotype and the other containing a rare haplotype (APOA5*2 or APOA5*3) which is correlated to raised triglyceride levels and approximately 0.6% or less than 1 percent of the population is homozygous with both chromosomes containing the rare haplotypes (*2/*2, *3/*3 or *2/*3), which correlates to the highest triglyceride levels. In addition to APOAV's strong association with triglyceride levels in Caucasians, a strong effect is also seen African-Americans and Hispanics where the minor allele frequencies are higher. Thus, a larger percent of African-Americans and Hispanics display increased triglycerides due to the genetic effect of APOAV. Specifically, APOA5*2 and/or APOA5*3 is present in 36% of African Americans and 51% of Hispanics and results in an ˜25% increase in triglycerides compared to APOA5*1 homozygotes.
[0131]Thus, the preferred embodiment includes a method of determining an individual's total risk of lipid-related diseases or disorders by identifying an individual's APOAV haplotype on each chromosome. One needs only genotype individuals at two different polymorphic loci, wherein one of those loci is SNP5, to determine which haplotypes the individual possesses, and whether the individual is heterozygous or homozygous for the rare or normal alleles (defining APOA5*3). The haplotypes can be easily determined by detecting the genotype of individuals at SNPs 1-3 or 6 (APOA5*2) and at SNP5 (APOA5*3) for both copies of chromosome 11. Based on the knowledge of what haplotypes the individual possesses, the amount of risk for lipid-related diseases or disorders can then be determined or predicted. For example, if the individual is genotyped and found to have a T at SNP3 on one chromosome and a C at SNP3 on the other chromosome, then it can be determined that the individual is heterozygous, having APOA5*2 haplotype on one of the chromosomes. Then genotyping the individual at SNP5 will distinguish whether the other chromosome is a rare haplotype (APOA5*3) or the normal haplotype (APOA5*1). Methods of detecting SNPs and genotyping are discussed in the Diagnostic Applications section.
[0132]G. Diagnostic Applications
[0133]The present embodiment enables genetic testing for APOAV and its correlation to increased triglyceride levels in people having polymorphisms deviating from the normal or "wild type" phenotype. Further, a combination test with APOC3 is suggested. Genetic testing may be carried out on a patient's DNA or RNA or protein, provided that antibodies capable of distinguishing mutant from wild type APOAV protein are available.
[0134]1. Antibodies to APOAV and its Variants
[0135]Antibodies including both polyclonal and monoclonal antibodies, and drugs that modulate the production of activity of APOAV possess certain diagnostic applications and may, for example, be utilized for the purpose of detecting the identity of the haplotype of individuals. For example, wild type APOAV and its variants may be used to produce both polyclonal and monoclonal antibodies in a variety of cellular media, by known techniques such as the hybridoma technique utilizing, for example, fused mouse spleen lymphocytes and myeloma cells. Likewise small molecules that mimic or agonize the activity(ies) of APOAV may be discovered or synthesized, and may be used in diagnostic and/or therapeutic protocols.
[0136]The general methodology for making monoclonal antibodies by hybridomas is well known. Immortal, antibody-producing cell lines can be created by techniques other than fusion, such as direct transformation of B lymphocytes with oncogenic DNA, or transfection with Epstein-Barr virus. See, e.g., M. Schreier et al., "Hybridoma Techniques" (1980); Hammerling et al., "Monoclonal Antibodies And T-cell Hybridomas" (1981); Kennett et al., "Monoclonal Antibodies" (1980); see also U.S. Pat. Nos. 4,341,761; 4,399,121; 4,427,783; 4,444,887; 4,451,570; 4,466,917; 4,472,500; 4,491,632; 4,493,890.
[0137]Panels of monoclonal antibodies produced against APOAV peptides can be screened for various properties; i.e., isotype, epitope, affinity, etc. Of particular interest are monoclonal antibodies that specifically bind and identify the alleles of APOAV, and can distinguish between the rare and the normal alleles of APOAV. In one preferred embodiment, a monoclonal antibody can be generated that specifically binds to the W19 position of the APOAV protein, which results from the rare SNP5 allele. Such monoclonals can be readily identified in, for example, gel-shift assays. High affinity antibodies are also useful when immunoaffinity purification of native or recombinant APOAV is possible.
[0138]A preferred method of generating these APOAV allele-specific antibodies is by first synthesizing peptide fragments. These peptide fragments should cover at least SNP5 and the adjacent amino acid sequence. Subsequent antibodies should be screened for their ability to distinguish the two protein variants. Since synthesized peptides are not always immunogenic on their own, the APOAV peptides should be conjugated to a carrier protein before use. Appropriate carrier proteins include but are not limited to Keyhole limpet hemacyanin (KLH). The conjugated peptides should then be mixed with adjuvant and injected into a mammal, preferably a rabbit through intradermal injection, to elicit an immunogenic response. Samples of serum can be collected and tested by ELISA assay to determine the titer of the antibodies and then harvested.
[0139]Polyclonal APOAV allele-specific antibodies can be purified by passing the harvested antibodies through an affinity column. Monoclonal antibodies are preferred over polyclonal antibodies and can be generated according to standard methods known in the art of creating an immortal cell line which expresses the antibody.
[0140]Additionally, spleen cells can be harvested from the immunized animal (typically rat or mouse) and fused to myeloma cells to produce a bank of monoclonal antibody-secreting hybridoma cells. The bank of hybridomas can be screened for clones that secrete immunoglobulins that bind the protein of interest specifically, i.e., with an affinity of at least 1×107 M-1. Animals other than mice and rats may be used to raise antibodies; for example, goats, rabbits, sheep, and chickens may also be employed to raise antibodies reactive with an APOAV protein. Transgenic mice having the capacity to produce substantially human antibodies also may be immunized and used for a source of antiserum and/or for making monoclonal antibody secreting hybridomas.
[0141]Bacteriophage antibody display libraries may also be screened for phage able to bind peptides and proteins specifically. Combinatorial libraries of antibodies have been generated in bacteriophage lambda expression systems and may be screened as bacteriophage plaques or as colonies of lysogens. For general methods to prepare antibodies, see Antibodies: A Laboratory Manual (1988), E. Harlow and D. Lane, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., incorporated herein by reference.
[0142]These antibodies can in turn be used to isolate APOAV proteins from normal or recombinant cells and so can be used to purify the proteins as well as other proteins associated therewith. Such antibodies are useful in the detection of specific alleles of APOAV proteins in samples and in the detection of cells comprising APOAV proteins in complex mixtures of cells. Such detection methods have application in screening, diagnosing, and monitoring lipid metabolism related diseases and other conditions, such as high levels of triglycerides.
[0143]2. Genotyping and Haplotyping
[0144]Any method known in the art can be used to identify the nucleotide present at one of the disclosed APOA5 polymorphic sites. Since the SNPs and haplotypes to be detected have been identified and specified in the present invention, detection will prove simple for one of ordinary skill in the art. Any number of techniques to detect the haplotype of an individual by genotyping the individual at certain polymorphic sites can be used, including, but not limited to, the following.
[0145]The nucleotide can be determined by sequencing analysis after DNA samples are subjected to PCR amplification. Preferably, the amplified DNA is subjected to automated dideoxy terminator sequencing reactions using a dye-primer cycle sequencing protocol. The sequencing reactions are then sequenced using any number of commercially available sequencing machines such as the ABI 377 or 3700 Sequence Analyzer (Applied Biosystems, Foster City, Calif.).
[0146]Techniques and methods of synthesizing and amplifying polynucleotides by litigation of multiple oligomers (LMO) onto a template-bound primer are also described by Akhavan-Tafti in U.S. Pat. Nos. 5,998,175; 6,001,614; 6,013,456; and 6,020,138, which are hereby incorporated by reference in their entirety. Short polynucleotides, 5 to 10 bases long, can be supplied as a library of oligonucleotides and are simultaneously ligated, using a suitable ligase enzyme, to a template-bound primer in a contiguous manner to produce a complementary strand of template polynucleotide. If the sequence to be synthesized is known, a set containing the minimum number of oligomers can be used and are then ligated by DNA Ligase in the correct order starting from the primer, uni- or bi-directionally, to produce the complementary strand of a single-stranded template sequence.
[0147]A preferred method is to use sequence detection/amplification assays such as the INVADER assays which are commercially available from Third Wave Technologies (Madison, Wis.) to genotype samples. Such systems rely on an enzyme-substrate reaction to amplify signal generated when a perfect match with an (rare) allele of APOAV is detected. See Dahlberg, J. et al., U.S. Pat. Nos. 5,846,717 and 5,888,780, which are hereby incorporated by reference in their entity.
[0148]A third preferred method is using methods that have been developed for examining single base changes without direct sequencing. For example, if a mutation of interest happens to fall within a restriction recognition sequence, a change in the pattern of digestion can be used as a diagnostic tool (e.g., restriction fragment length polymorphism [RFLP] analysis) See U.S. Pat. Nos. 5,547,835; 6,221,601; 6,194,144 which are hereby incorporated by reference in their entirety. Other methods of SNP analysis are performed by companies such as Sequenom (San Diego, Calif.), which can genotype many samples very quickly and with great accuracy, non-sequencing methods such as MALDI-TOF, miniaturized chip-based array formats and mass spectrometry.
[0149]Other genotyping methods suited for detection of SNPs include, but are in no way limited to, LCR (ligase chain reaction), Gap LCR (GLCR), using allele-specific primers, mismatch detection assays, microsequencing assays, and hybridization assay methods.
[0150]3. Oligonucleotide Primers and Probes
[0151]Various methods for screening for genetic APOAV abnormalities in individuals can be employed. Polynucleotides according to SEQ ID NOs: 1-3 and 5-7 can also be used in gene marker assays, probes, primers for uses including, but not limited to, PCR, sequencing, hybridization assays and probes. Variations that are at least 95% or more homologous to the sequences of APOAV polynucleotides (e.g. SEQ ID NOs: 1-3, 5 and 6) may also be used for comparison studies and in any of the above listed types of assays. In another embodiment, polypeptides that are at least 95% of more homologous to APOAV protein (e.g. SEQ ID NO: 4) or to the protein generated from polynucleotide sequences selected from the group consisting of SEQ ID NO: 1-3, 5-6 may be used for lipid studies.
[0152]The preferred embodiment also encompasses APOAV oligonucleotide primers made from SEQ ID NO: 3 and 4 and capable of amplifying the DNA sequence of and surrounding each of SNPs 1-6. Basic primer design considerations such as annealing/melting temperature, length, repetitive DNA, proximity to the SNP, and specificity will be appreciated and addressed by one skilled in the art. Many programs that enable one to pick and design custom primers address these considerations, such as PRIMER3 (S. Rozen and H. J. Skaletsky).
[0153]Suitable primers such as those disclosed in Table 3, SEQ ID NOs: 8-36 and primers made from sequence up to about 500 base pairs away from the SNP can be used for amplification, may be used to assay SNP5 (position 12974). and/or sequencing these SNPs. For example, SEQ ID NO: 24 (AV1-F 5' TGCTCACCTGGGCTCTGGCTCTTC) and SEQ ID NO: 25 (AV1-R 5' CCAGAAGCCTTTCCGTGCCTGGGCGGC) which lie in SEQ ID NO: 3 and 4 at positions 12824-12847 and 12976-13002 respectively Furthermore, depending upon the genotyping strategy used, other probes and primers can be designed from SEQ ID NOs: 1-6 for use in such assays as PCR-RFLP and PCR INVADER assays (Third Wave Technologies, Madison, Wis.).
[0154]The following table shows primers that can be used to amplify genomic DNA surrounding SNPs 1-6 by such methods as PCR. The examples of forward and reverse primers that can also be used to amplify sequence containing each of the described SNPs 1-6. The resulting amplified product can be genotyped by methods including, but not limited to, sequencing, mass spectrometry, RFLP, and INVADER assays. Primers such as those disclosed in Table 3, SEQ ID NOS: 8-36 and primers made from sequence up to about 500 base pairs away from the SNP can be used for amplification and/or sequencing these SNPs. For example, SEQ ID NO: 24 (AV1-F 5' TGCTCACCTGGGCTCTGGCTCTTC) and SEQ ID NO: 25 (AV1-R 5' CCAGAAGCCTTTCCGTGCCTGGGCGGC
TABLE-US-00003 TABLE 3 SEQ Length of ApoA5 ID Position on amplified SNP NO Primer Sequence ApoA5 gene sequence ApoA5- 39 ATGACCTGTGGGAAGACATCACT Forward 14470-14492 455 bp SNP1 40 AGCCAGAAGTGACTAGAGCCAAA Reverse 14902-14924 ApoA5- 41 AGTCCCCAGAATCAAAGGATGAT Forward 13341-13363 497 bp SNP2 42 ATCGTGTAGGGCTTCAGTTGCT Reverse 13816-13837 ApoA5- 43 CCTGTCTTCTCAGAGCAGGTAATG Forward 12784-12807 285 bp SNP5 44 AGCCATCTTCTGCTGATGGATCT Reverse 13046-13068 ApoA5- 45 AAGACACCCTAGCCTCCTTGACT Forward 12602-12624 566 bp SNP3 + 46 ACAGAGGTTGAGGCAGCAGAG Reverse 13147-13167 SNP6 ApoA5- 47 GTAGTGAAAATCAGGGGCCTTCT Forward 484-506 158 bp SNP4 48 ATGCATAAACCCAAAGGGAAAAT Reverse 619-641
[0155]In one embodiment of the invention, fragments of various lengths of APOAV DNA may be placed onto solid supports for use in gene chips or other parallel formats for assay purposes. In general, these methods employ arrays of oligonucleotide probes that are complementary to targeted nucleic acid sequences, and allow for detection when the sample hybridizes to a probe on the array. In preferred embodiments, the nucleic acid sequences are APOAV fragments of about 15-30 nucleotides in length, specifically sequences containing APOAV SNPs 1-6. In further embodiments, the chip may comprise an array including at least one of the sequences selected from the group consisting of amplification primers listed in Tables 3 and 4. See D. J. Lockhart, et al., "Expression monitoring by hybridization to high-density oligonucleotide arrays," Nature Biotechnology, 14:1675-1680, December 1996, for useful methods and heuristics in designing oligonucleotide probes from APOAV fragments.
[0156]Chips of various formats from companies such as Agilent Technologies (Palo Alto, Calif.) and Affymetrix (Santa Clara, Calif.) can be produced on a customized basis by various methods. Alternatively, DNA microarray chips are fairly inexpensive to make and assemble. Individual samples to be tested are then contacted with the oligonucleotide probes and the genotype and/or haplotype of the sample can be determined based on detection of the hybridization between the probes and the sample. A suitable DNA micro-array is disclosed in Brown et al. U.S. Pat. No. 5,807,522
[0157]H. Modulating and Regulating, APOAV Expression
[0158]The preferred embodiment also encompasses methods of modulating and regulating APOAV expression. Current therapies known to effect lipid metabolism can also be studied for their effect in modulating and regulating APOAV expression. Current methods include but are not limited to, administration of fibrates and other molecules important in inflammatory response, cholesterol regulating drugs, and glucose and insulin regulatory molecules.
[0159]For example, fibrates are hypolipidemic drugs with pleiotropic effects on lipid metabolism including the reduction of plasma triglycerides. Suitable fibrate drugs are disclosed in U.S. Pat. No. 4,318,923 issued to Hamayaki et al. And hereby incorporated by reference. Classically, the triglyceride lowering action of fibrates is explained by decreased hepatic secretion of VLDL and an enhancement in plasma triglyceride clearance. Several studies established that this effect is mediated through the induction of lipoprotein lipase expression and down-regulation of APOC3 expression by fibrates. A major means by which fibrates regulate the expression of lipid metabolism-related genes by fibrates has been shown to be via activation of the peroxisome proliferator-activated receptor alpha (PPARα). Three distinct PPARs (α, β, and γ) have been described in different species. Whereas PPARβ appears ubiquitously expressed, PPARα and PPARγ are mainly expressed in liver and in adipose tissue, respectively. PPARs are ligand-activated nuclear receptors that dimerize with the retinoid X receptor (RXR) and bind to specific DNA sequence defined as peroxisome proliferator response elements (PPRE). Upon binding, PPARs activate gene transcription.
[0160]Given the determinant link between APOAV and plasma triglycerides and the widespread use of fibrates in the treatment of dyslipidemia, one could investigate how fibrates affect APOAV gene expression and consequently influence plasma triglyceride levels. It is very likely that studies in mice and in vitro studies with human hepatocytes reveal that fibrates dramatically increase APOAV expression.
[0161]To determine if fibrates effect on apoa5 is mediated via the PPARα pathway, sequence conservation comparison, in vitro promoter analyses and functional studies of putative PPREs to the APOAV gene can be performed. These and other studies may identify fibrates acting via PPARα as a crucial regulator of the new apolipoprotein APOAV and suggest a novel and likely clinically relevant mechanism of how PPARα activators can act on lipid homeostasis. Modulation of APOAV via a PPARα pathway would prove to offer a new target for therapeutic interventions designed at correcting hypertriglyceridemia and at limiting triglyceride-associated cardiovascular risk.
A. I. Drug Design and Therapies Based on Sequence Variations
B. 1. Drug Screening and Design
[0162]In addition to modulating the expression of the APOAV gene, the present embodiment further contemplates an alternative method for identifying specific agonists and activators using various screening assays known in the art.
[0163]The preferred embodiment contemplates screens for small molecule ligands or ligand analogs and mimics, as well as screens for natural ligands that bind to and agonize APOAV activity in vivo or result in lowered levels of triglycerides. For example, natural products libraries can be screened using assays of the invention for molecules that agonize APOAV activity. Knowledge of the primary sequence of the various APOAV allele variants and other structural motifs of APOAV (i.e., amphipathic α-helices), and the similarity of those sequences with domains contained in other proteins, can provide an initial clue to agonists of the protein. Identification and screening of agonists is further facilitated by determining structural features of the protein, e.g., using X-ray crystallography, neutron diffraction, nuclear magnetic resonance spectrometry, and other techniques for structure determination. These techniques provide for the rational design or identification of agonists of APOAV that will reduce triglyceride levels.
[0164]Another approach uses recombinant bacteriophage to produce large libraries. Using the "phage method" Scott and Smith, 1990, Science 249: 386-390 (1990); Cwirla, et al., Proc. Nat. Acad. Sci., 87: 6378-6382 (1990); Devlin et al., Science, 249: 404-406 (1990), very large libraries can be constructed. A second approach uses primarily chemical methods, of which the Geysen method, Geysen et al., Molecular Immunology 23: 709-715 (1986); Geysen et al. J. Immunologic Method 102: 259-274 (1987), and the method of Fodor et al. Science 251: 767-773 (1991) are examples. Houghton in U.S. Pat. No. 4,631,211, and Rutter et al., U.S. Pat. No. 5,010,175, describe methods to produce a mixture of peptides that can be tested as agonists or antagonists.
[0165]In another aspect, synthetic libraries and the like can be used to screen for ligands that recognize and specifically bind to APOAV and its variants. In one such example, a phage library can be employed. Phage libraries have been constructed which when infected into host E. coli produce random peptide sequences of approximately 10 to 15 amino acids, Parmley and Smith, Gene, 73: 305-318 (1988), Scott and Smith, Science, 249: 386-249 (1990). Specifically, the phage library can be mixed in low dilutions with permissive E. coli in low melting point LB agar which is then poured on top of LB agar plates. After incubating the plates at 37° C. for a period of time, small clear plaques in a lawn of E. coli will form which represents active phage growth and lysis of the E. coli. A representative of these phages can be absorbed to nylon filters by placing dry filters onto the agar plates. The filters can be marked for orientation, removed, and placed in washing solutions to block any remaining absorbent sites. The filters can then be placed in a solution containing, for example, a radioactive fragment of APOAV. After a specified incubation period, the filters can be thoroughly washed and developed for autoradiography.
[0166]Plaques containing the phage that bind to the radioactive binding domain can then be identified. These phages can be further cloned and then retested for the ability to bind to APOAV and/or its variants. Once the phages have been purified, the binding sequence contained within the phage can be determined by standard DNA sequencing techniques. Once the DNA sequence is known, synthetic peptides can be generated which represent these sequences.
[0167]The effective peptide(s) can be synthesized in large quantities for use in in vivo models and eventually in humans to reduce triglyceride levels. Synthetic peptide production is relatively non-labor intensive, easily manufactured, quality controlled and thus, large quantities of the desired product can be produced quite cheaply. Similar combinations of mass produced synthetic peptides have recently been used with great success. Patarroyo, Vaccine, 10: 175-178 (1990). The peptides may be prepared according to known pharmaceutical technology. They may be administered singly or in combination, and may further be administered in combination with other cardiovascular drugs. They may be conventionally prepared with excipients and stabilizers in sterilized, lyophilized powdered form for injection, or prepared with stabilizers and peptidase inhibitors of oral and gastrointestinal metabolism for oral administration.
[0168]Another embodiment is to create a cell system which has the 5' regulatory region of the human APOAV gene coupled to a reporter gene, such as luciferase, as is known in the art. The luciferase gene is positioned at the start of the APOAV gene. Candidate drugs are screened against the cell system and scored for their ability to upregulate the luciferase expression. These drugs will have use in lowering plasma triglycerides, according to the findings of the inventors that increased levels of the APOAV protein cause lowered plasma triglycerides as shown by Example 3.
[0169]Other high-throughput methods of drug design and discovery are discussed in Landro, J. A. et al., "HTS in the new millennium, the role of pharmacology and flexibility," J Pharmacol Toxicol Methods, 2000 July-August; 44(1):273-89, describing target identification, reagent preparation, compound management, assay development, high-throughput library screening and other methods for drug discovery and screening, and is hereby incorporated by reference in its entirety.
[0170]While lowering triglyceride levels is an aim of the preferred embodiment, other embodiments target other metabolite levels such as insulin or glucose levels, by modulating APOAV gene expression. As show in Example 9, APOAV levels can lead to changes in plasma glucose or insulin levels or other metabolite levels. Therefore, alternate embodiments contemplate the aforementioned methods of drug screening and drug design for the purpose of modulating APOAV to affect other metabolite levels.
[0171]2. Gene Therapy with APOAV
[0172]The preferred embodiment also encompasses uses of the APOAV gene for gene therapeutics such as those described by Gabor M. Rubanyi, "The future of gene therapy," Molecular Aspects of Medicine 22(2001): 113-142, and is hereby incorporated by reference in its entirety. Rubanyi describes existing and future methods of gene therapy and the technical hurdles gene therapy faces in the future are made possible through the sequences disclosed in SEQ ID NO: 1-7. Other examples are drug therapies aimed at raising the levels of APOAV in any human patient with high triglyceride levels. These will provide a suitable way to reduce triglyceride levels and thereby reduce the risk of cardiovascular disease. Further aims include determining how APOAV exerts its effect upon triglyceride and other metabolite levels and to stimulate that pathway by non-APOAV means as a way to lower triglycerides or modulate other metabolite levels.
[0173]As described in an earlier section, various types of gene delivery vectors can be used including, but definitely not limited to, plasmids, YACs (Yeast Artificial Chromosomes), BACs (Bacterial Artificial Chromosomes), bacterial vectors, bacteriophage vectors, viral vectors (for example, retroviruses, adenoviruses and viruses commonly used for gene therapy), non-viral synthetic vectors, and recombinant vectors. Delivery of the vector and/or construct for gene therapy in a preferred embodiment is by viral infection or injection intravenously although delivery can be by any other means as described previously.
[0174]A preferred embodiment is modelled after the method described by Tangirala R K et al., Circulation, 1999 Oct. 26; 100(17):1816-22, wherein the regression of atherosclerosis was induced by liver-directed gene transfer of apolipoprotein A-I in mice. The preferred embodiment contemplates a similar protocol of gene transfer as Tangirala et al. based on the same target tissue and the desire to express APOAV endogenously in the liver. A second-generation recombinant adenovirus encoding SEQ ID NO: 1 or 2, human APOAV cDNA can be constructed as described by Tsukamoto K. et al., Journal of Lipid Research, 1997:38, 1869-1876. Briefly, pAdCMV APOAV can be linearized with an enzyme and co-transfected into cells along with adenoviral DNA isolated and digested. The cells are then overlaid with agar and incubated at 32° C. for about 15 days. Plaques positive for APOAV cDNA are subjected to a second round of plaque purification, and the recombinant adenovirus is then expanded in cells at 32° C. A null adenovirus can be constructed and expanded in an identical manner. All viruses are then purified and stored appropriately.
[0175]While much of gene therapy uses vectors as a means of delivery, other methods of delivery to the somatic cells of a patient may be utilized. The preferred embodiment also contemplates the delivery of APOAV polynucleotides by encapsulation by compositions such as, hydrogels and microgels, liposomes, and other lipid or polymer carriers. Furthermore, the APOAV polynucleotides can be delivered naked, without any means of receptor-mediated entry or other carrier into the patient's cells.
[0176]3. Therapeutics Using APOAV
[0177]The presently disclosed APOAV polynucleotides and polypeptides, and fragments thereof, may be prepared according to known pharmaceutical technology. They may be administered singly or in combination, and may further be administered in combination with other cardiovascular or triglyceride-lowering drugs. They may be conventionally prepared with excipients and stabilizers in sterilized, lyophilized powdered form for injection, or prepared with stabilizers and peptidase inhibitors of oral and gastrointestinal metabolism for oral administration. They may also be administered by methods including, but not limited to, intravenous, infusion, rectal, inhalation, transmuscosal or intramuscular administration.
[0178]The APOAV polynucleotides and polypeptides can be isolated, recombinant or synthesized, so long as the polynucleotides and polypeptides maintain APOAV functionality. In a preferred embodiment, the APOAV polynucleotide of SEQ ID NO: 1-3 or 5 is delivered in the therapy whereby the APOAV gene is over expressed in the organism. In other preferred embodiments, the polypeptide or active APOAV protein of SEQ ID NO: 4 is delivered to lower triglyceride levels.
[0179]Combining data from stratification and genetic studies with diagnostic tests to determine the best method of treatment for person based upon such criteria as specific haplotype, age, gender and ethnicity. For example, after finding in a genetic study that individuals having haplotypes APOA5*1/*2 and a specified triglyceride level, respond to a certain dosage of fibrates (e.g. their triglyceride levels dramatically are reduced by an average 50 dl/mL), physicians and medical providers can tailor triglyceride therapy to prescribe the most effect dosage of triglyceride lowering medication. After ordering the diagnostic tests described earlier for individuals to determine what haplotype they possess, doctors and other medical providers can then prescribe the most effective dosage to achieve the goal of dramatically reducing triglycerides to persons having the haplotypes of APOA5*1/*2. In other embodiments, the sample of individuals can be broken down according to other criteria, including, but not limited to, age, gender, ethnicity, diet or the presence or absence of certain disease symptoms.
[0180]J. Methods of Genetic Analysis and Association Studies
[0181]In general, the SNPs of this invention find use in any method known in the art to demonstrate a statistically significant correlation between a genotype and phenotype, and between a haplotype and phenotype. Preferably, the SNPs are used in studies to determine their correlation to lipid metabolism disorders. More preferably, the SNPs are used in studies to determine whether they are causative mutations of lipid metabolism disorders.
[0182]The described polymorphisms can be used to separate individuals based on any phenotypic trait. For instance, patients can be treated with fibrates and their triglyceride levels can be determined. Individuals can then be separated based on their APOAV genotype/haplotype (APOA5*1, APOA5*2, or APOA5*3) and their average triglyceride level determined. This will enable a physician to address if APOAV polymorphisms influence how responsive an individual will be to a triglyceride therapy.
[0183]A similar strategy could be used for any drug therapy. As another example, a certain diseased group of individuals could be separated based on their APOAV genotype/halotype, and all the average phenotypes from these groups can be examined for differences. If any phenotype display shows a difference, this would be a phenotype that APOAV may influence. For instance, a group of diabetics could be separated based on their APOAV genotype. Numerous phenotypes in these subgroups can be averaged and compared, such as glucose levels. If there is a difference in glucose levels, this would support the proposal that APOAV influences glucose levels in diabetes. Another example would be to look at every type of cardiovascular disease and see if there is an increased frequency of the minor haplotypes in the diseased group compared to controls. If there is a difference then APOAV likely contributes to this disease.
[0184]Criteria or methods for selecting individuals for treatments, drug trials and any of the studies described herein include, but are not limited to, such criteria for eligibility as: willingness to participate in program, no medication use likely to interfere with lipid metabolism, percentage of ideal body weights according to such tables and indices available such as Metropolitan Life Insurance Company Tables (1985), certain body mass index, free of chronic disease, nonsmoker, daily alcohol consumption, related or unrelated to other subjects in the study, family and other relatives living and willing to donate blood samples or submit to studies, belonging to certain age and/or ethnicity groups, possessing defined levels of plasma total cholesterol, triacylglycerols and blood pressure, adherence to diet and/or exercise protocol and requirements, and any other measurable genotypic or phenotypic trait. In addition to meeting this criteria, analysis of the plasma lipids, lipoproteins, lipoprotein subfractions; triglycerides and apolipoproteins of the subjects should be done to develop complete profiles of each subject.
[0185]For more examples of preferred subject criteria and methods of measuring triglycerides, lipoproteins, cholesterol, and other related lipid metabolism proteins and methods for conducting clinical trials as herein described, see D. Dreon et al., Arteriosclerosis, Thrombosis, and Vascular Biology. 1997; 17:707-714; D. Dreon et al., Am J Clin Nutr. 1998; 67:828-36; and Williams et al., Arteriosclerosis, Thrombosis, and Vascular Biology. 1997; 17:702-706, which are hereby incorporated by reference in their entirety.
[0186]The preferred embodiment permits genetic analysis studies between the disclosed SNPs 1-6, the APOAV haplotypes (APOA5*1/*2/*3) and any phenotype. In general, the SNPs and haplotypes of the present invention find use in any method known in the art to demonstrate a statistically significant correlation between a genotype and phenotype. The genetic analysis using the SNPs and haplotypes that may be conducted include but are not limited to linkage analysis, population association studies, allele frequencies, haplotype frequencies, and linkage disequilibrium.
[0187]Linkage analysis is based upon establishing a correlation between the transmission of genetic markers and that of a specific trait throughout generation within a family. Thus, the aim of linkage analysis is to detect marker loci that show co-segregation with a trait of interest. Linkage analysis correlating APOAV SNPs and haplotypes and the trait of high triglyceride levels within families or people/ethnic groups are an aim of this invention. The examples demonstrate linkage analysis studies that correlated the presence of either APOA5*2 or APOA5*3 with raised triglyceride levels in the Caucasian, African-American and Hispanic populations. Further linkage analysis is also contemplated for studies of other people and ethnic groups, and further regional studies including groups in other countries. Linkage analysis can be performed according to parametric or non-parametric methods.
[0188]Frequency of alleles and haplotypes in a population is also another genetic analysis study contemplated by the invention. Using the genotyping and haplotyping methods described in the earlier "Genotyping and Haplotyping" section, one skilled in the art can determine the frequency of SNPs 1-6 and haplotypes APOA5*1/*2/*3 in a given population. While several methods of estimating allele frequency are possible, genotyping individual samples is preferred over genotyping pooled samples due to higher sensitivity, reproducibility and accuracy. Furthermore, many genomic and large-scale sequencing centers enable rapid genotyping and haplotyping by sequencing methods and thereby provide rapid data production.
[0189]Association studies between APOAV SNPs and haplotypes and any phenotype can also be performed on a random sample of people, anywhere from a few hundred to tens of thousands. After collecting various parameters for each individual participating the study, such as height, weight, triglyceride levels, medical history, etc., the sample group can be separated according to various genotypes at APOAV. Any repeated differences in the parameters in individuals that are observed are likely traits that are associated with one of the APOAV genotypes or haplotypes. Examples show that there are differences in triglyceride levels that are associated with APOAV haplotypes *1, *2 and *3, however, there are likely other associations that can be subject to study. Other parameters to observe include, but are not limited, presence of cardiovascular disease risks, other lipid, lipoprotein or protein levels, instances of diabetes, obesity, inflammatory diseases, inflammatory response, apolipoprotein expression levels, alcoholism and drug abuse.
[0190]Alternate embodiments also encompass a method of determining if SNPs 1-6 are in linkage disequilibrium with any lipid-related or other disorders.
[0191]Studies correlating the genotype/haplotype with methods and treatments of high triglycerides or other lipid-related disorder are also contemplated. Segregation of individuals in the study according to their response (e.g. lowering of triglyceride levels) to various drug therapies and combinations and then according to the APOAV allele frequency. The result of stratification of population studies would enable doctors and medical care providers to prescribe therapy with greater accuracy, and with greater success rates. Thus, therapy prescribed would be "tailor-made" for individuals based upon their haplotypes.
[0192]Statistical methods and computer programs useful for linkage analysis, genetic analysis and association studies are well-known to those skilled in the art. Any statistical tool useful to test for statistically significant associations between genotypes, haplotypes and phenotypes, comparisons and correlations between a biological marker and any physical trait, and frequency comparisons may be used.
[0193]Statistical analyses can be carried out using the SAS computer program (SAS, Cary, N.C.) and similar programs. Plasma triglyceride concentrations can be compared among different genotype groups using Wilcoxon's test and the like. Allele frequencies should be compared using such tests as Fisher's exact test. To determine pairwise linkage disequilibrium (LD) between SNPs, haplotype frequencies, estimations can be done using the Expectation-Maximization (EM) algorithm implemented in the computer program ARLEQUIN v. 2.0 ((Excoffier and Slatkin, Mol. Biol. Evol. 1995, 12 (5):921-927), and downloadable from http://lgb.unige.ch/arlequin/), an exploratory population genetics software environment.
[0194]Pair-wise measure of linkage disequilibrium (|D'|) can be calculated for all combinations of frequencies as described by R. C. Lewontin, Genetics 120, 849-52 (1988). A |D'| value of 1 indicates complete linkage disequilibrium between two markers.
[0195]Examples of useful statistical methods and techniques include Analysis of Variance (ANOVA), Fischer's test for pair-wise comparison and Wilcox's test, generally carried out using programs such as SPSS (Chicago, Ill.), STATVIEW and SAS (both available from SAS, Cary, N.C.).
EXAMPLE 1
[0196]Identifying and Isolating APOAV
[0197]Orthologous mouse genomic DNA was isolated from a pooled BAC library using the polymerase chain reaction (PCR) with mouse primers: apoAI-F1-5'-GAGGATGTGGAGCTCTACCGC-3' (SEQ ID NO:8) and apoAI-R1-5'-CTGTGTGCGCAGAGAGTCTACG-3') (SEQ ID NO:9) (RPCI-23, BACPAC Resources, Children's Hospital Oakland Research Institute; (See K. Osoegawa, et al., Genome Res 10, 116-28 (2000)). Positive clone RPCI-23-175F2 was identified, randomly sheared, sub-cloned and sequenced to approximately six-fold coverage according to methods described by I. Dubchak, et al., Genome Res 10, 1304-6 (2000) and G. G. Loots, et al., Science 288, 136-40 (2000). The sequence was deposited in GenBank (GenBank accession number AF401201). Human and mouse sequence comparisons were performed as previously described. Protein analyses were performed using the web-based Predict-Protein package, COILS (A. Lupas, et al., Science 252, 1162-4 (1991).), and SignalP (H. Nielsen, et al., Protein Eng 10, 1-6 (1997)).
[0198]The VISTA (www-gsd.lbl.gov/vista) graphical plot in FIG. 1B displays the level of homology between human and the orthologous mouse sequence spanning the apoAI/CIII/AIV cluster. Human sequence is represented on the x-axis and the percent similarity with the mouse sequence is plotted on the y-axis (ranging from 50-100% identity). Once the mouse sequence had been generated and the comparison obtained, a relatively high level of homology was observed in the region of the present APOAV, as can be seen from the plot.
[0199]To identify expression patterns of APOAV, mice were sacrificed and tissues harvested for either total RNA isolation using the RNA easy-midi protocol (Qiagen, Valencia, Calif.) or for polyA mRNA isolation using the FastTrack 2.0 system (Invitrogen, Carlsbad, Calif.). Approximately 10 μg of total RNA or 2 μg of polyA MRNA were separated in 1.0% agarose by gel electrophoresis and the RNA was transferred to a charged nylon membrane (Ambion, Austin, Tex.). The RNA blots were hybridized with [α-32P]dCTP random-primed mouse apoA5 and human APOAV probes in ULTRAhyb buffer (Ambion, Austin, Tex.). Probe templates were generated by PCR amplification of liver cDNA using degenerate primers degApoAV-F2-5'-GCGCGTGGTGGGRGAAGACA-3' (SEQ ID NO:22) and degApoAV-R2-TCGCGCAGCTGGTCCAGGTT-3' (SEQ ID NO:23). Filters were washed in 2×saline sodium citrate at room temperature for 20 minutes and in 0.1×SSC at 42° C. for 20 minutes, followed by autoradiography visualization.
[0200]The results of the RNA blots are described herein. (A) A mouse apoA5 cDNA probe was hybridized to a multi-tissue RNA blot from wild-type mice. Each lane contained one of eight mouse tissues (Clontech, Palo Alto, Calif.), respectively: 1, heart; 2, brain; 3, spleen; 4, lung; 5, liver; 6, skeletal muscle; 7, kidney; and 8, testis. The probes hybridized only to two transcripts approximately 1.3 and 1.9 kb in size in liver tissue (lane 5). (B) A human APOA5 cDNA probe was hybridized to a RNA blot containing eight human tissues (Clontech, Palo Alto, Calif.), respectively: 1, heart; 2, brain; 3, placenta; 4, lung; 5, liver; 6, skeletal muscle; 7, kidney; and 8, pancreas. The probes hybridized only to two transcripts approximately 1.3 and 1.9 kb in size in liver tissue (lane 5). (C) A human-specific APOA5 cDNA probe was hybridized to total RNA blots from human apoA5 transgenic mice and controls. Lane assignments are as follow: 1,5 transgenic liver; 2,6 transgenic intestine; 3,7 wild-type liver; 4,8 wild-type intestine. The probes hybridized only to two transcripts approximately 1.3 and 1.9 kb in size in transgenic liver tissue (lanes 1 and 5). (E) Northern blot analysis of various genotype mice using mouse APOAS probe following the apoA5 targeting event. Each lane contains liver mRNA from a wild-type (lane 1), heterozygous (lane 2) and homozygous knockout mouse (lane 3). To confirm similar amounts of RNA were loaded per lane, duplicate gels were examined by ethidium bromide staining. There was a large amount of transcript around 1.9-2 kb in lane 1 and a smaller band in lane 2 of same weight, while lane 3 showed no transcript.
EXAMPLE 2
[0201]Transgenic Non-Human Animals to Assess the Function of APOAV and apoAV
[0202]Restriction enzyme predictions for human genomic sequence (Genbank Accession Number AC007707) indicated that the entire human APOAV gene, but not neighboring genes, was contained within a 26 kbp XhoI DNA fragment (corresponding to approximately 1-27 kbp in FIG. 1B). BAC DNA corresponding to the clone sequenced from this region was prepared by standard alkaline lysis with a chromatography column (Qiagen, Valencia, Calif.), digested with the restriction enzyme XhoI and separated in 1% agarose by pulse-field gel electrophoresis. The 26 kbp XhoI DNA fragment containing human APOAV was purified using QIAEX II gel purification (Qiagen, Valencia, Calif.), adjusted to a final concentration of ˜1 ng/ml and micro-injected into fertilized FVB inbred mouse eggs using standard procedures. See K. A. Frazer, G. Narla, J. L. Zhang, E. M. Rubin, Nat Genet 9, 424-31 (1995).
[0203]Two founder transgenic mice were identified as determined by PCR amplification using primers hAPOA5-intrn-F1-5'-CCCGCTGCAGTCCCCAGAAT-3' (SEQ ID NO:10) and hAPOA5-intrn-R1-5'-CAGGGTCGAGGGCTCTTGTCCT-3' (SEQ ID NO:11). Each founder line was expanded by breeding to isogenic FVB strain mice (The Jackson Laboratory, Bar Harbor, Minn.).
[0204]The targeting construct to delete mouse apoA5 was built using PCR products amplified from BAC-RPCI-23-175F2 DNA (BACPAC Resources, Children's Hospital Oakland Research Institute). The first homology arm was PCR-amplified using primers containing introduced 5' restriction sites for XbaI and EcoRI, respectively: mAV-XbaI-F1-5'-TGACTCTAGATACCCTTGGTCCCATGTTCCAGAT-3' (SEQ ID NO:12) and mAV-EcoRI-R1-5'-CATTGAATTCGACAAGAGAAAGACGGGGCTCAAG-3' (SEQ ID NO:13). The resulting 4.2 kbp PCR product was cloned into pXL-Topo (Invitrogen, Carlsbad, Calif.), DNA prepared by standard alkaline lysis (Qiagen, Valencia, Calif.) and digested with EcoRI according to the manufacturer's recommendations (New England Biolabs, Beverly, Mass.). A 4.2 kbp EcoRI fragment was gel-purified and cloned into the EcoRI site of the pPN2T vector to yield pPN2T-Arm1 (C. Paszty, et al., Nat Genet 11, 33-39 (1995)). Clones were PCR screened for inserts using the above described primers and positive clones were sequenced for proper orientation.
[0205]The second homology arm was PCR-amplified using primers mAV-NotI-F4-5'-TATGACTGCGGCCGCCACCAATCCCACATCTAAGCATCT-3' (SEQ ID NO:14), containing an introduced 5' NotI restriction site, and mAV-XhoI-R3-5'-GCTCGGTTCTGGGCACAGAGA-3' (SEQ ID NO:15). The resulting 5.3 kbp PCR product containing an endogenous internal XhoI restriction site was digested with NotI and XhoI to yield a 5.1 kbp fragment which was directionally cloned into the XhoI and NotI sites of the pPN2T-Arm1 vector to yield final vector pPN2T-apoAV-KO. 129/SvJ ES cells (Incyte Genomics, Palo Alto, Calif.) were electroporated with 20 μg of the NotI linearized targeting construct and subsequently selected in 200 μg/ml G418 and 0.5 μg/ml FIAU for 8 days. Individual clones were isolated, expanded and screened by Southern blot analysis.
[0206]The external 3' probe was amplified by PCR using primers mApoAV-3' probe-F2-5'-CTTGAGGATGGGCATCAGCTGTAT-3' (SEQ ID NO:16) and mApoAV-3'probe-R2-5'-GCTCACTAACAGCGCTCTTGCCT-3' (SEQ ID NO:17). Targeted clones were injected into C57BL/6 blastocysts and chimeric males were bred to C57BL/6 females (The Jackson Laboratory, Bar Harbor, Minn.). Agouti offspring were tested for germline transmission of the targeted allele by PCR using primers specific to the neomycin gene (NeoF1-5'-CTTTTTGTCAAGACCGACCTG-3' (SEQ ID NO:37) and NeoR1-5'-AATATCACGGGTAGCCAACGC-3' (SEQ ID NO:38)) and heterozygous animals were intercrossed to obtain homozygous deletion animals for the mouse apoAS locus. Offspring were genotyped with PCR primers designed to the neomycin gene and with primers contained within the apoA5 deleted interval (mApoA5-F2-5'-ACAGTTGGAGCAAAGGCGTGAT-3' (SEQ ID NO:18) and mApoA5-R2-5'-CTTGCTCGAAGCTGCCTTTCAG-3' (SEQ ID NO: 19)). Properly targeted embryonic stems cells were identified using an external 3' probe which detects a 17 kb EcoRI fragment wild-type allele and a 10 kb EcoRI fragment upon targeting.
EXAMPLE 3
[0207]Plasma Triglyceride and Cholesterol Levels for APOAV Transgenic and Knockout Mice
[0208]Referring now to FIG. 3, results from the present human APOAV transgenic mice and the apoAV knockout mice are shown. Plasma triglyceride and cholesterol levels for apoAV transgenic and knockout mice on standard chow diet are illustrated. (A) Human APOAV transgenic mice compared to isogenic FVB strain control littermates (n=48 for transgenics; n=44 for controls; student t-test *p<0.0001 for transgenic versus control) have a ˜70% decrease in triglyceride levels. (B) Mice lacking APOAV compared to mixed 129Sv/C57B16 strain controls littermates (n=13 for wild-type, +/+; n=22 for heterozygotes, +/-; n=10 for homozygous knockouts, -/-; student t-test **p<0.001 for wild-type versus knockout) have a 400% increase in triglyceride levels. Error bars correspond to the standard deviation for both graphs.
[0209]The transgenic mice had approximately three-fold lower levels of plasma triglyceride when compared with control littermates ((0.32±0.11 (S.D.) mg/ml versus 0.90±0.29; T-test p<0.0001). Similar data were obtained from a second independent founder line (data not shown).
[0210]Mice lacking apoA5 were compared to mixed 129Sv/C57B16 strain control littermates (n=13 for wild-type, +/+; n=22 for heterozygotes, +/-; n=10 for homozygous knockouts, -/-; student t-test **p<0.001 for wild-type versus knockout) (FIG. 3B). Despite the lack of apoA5 transcript, mice homozygous for the deletion were born at the expected Mendeliai rate and appeared normal. In contrast to the decreased triglyceride levels noted in APOAV transgenics, apoA5 knockout mice had approximately four-fold higher levels of plasma triglyceride when compared with wild-type littermates (1.53±0.77 (S.D.) mg/ml versus 0.37±0.12; T-test p<0.001) (FIG. 3B). Error bars correspond to the standard deviation for both graphs.
[0211]Characterization of lipoprotein particles by fast protein liquid chromotography revealed that levels of very low density lipoprotein (VLDL) particles were increased in the homozygous knockout mice and decreased in the transgenic mice compared with controls. VLDL levels in a heterozygous knockout mouse were intermediate between the homozygous knockout and control mouse. The peak VLDL elution volumes were similar in all animals, indicating comparable VLDL particle size, and levels of other lipoproteins were not significantly altered.
EXAMPLE 4
[0212]Genotyping Human Individuals
[0213]Blood samples were collected after a 5-hour fast by retro-orbital bleeding using heparinized micro-hematocrit tubes. Total cholesterol and triglyceride concentrations were measured using enzymatic methods on a Gilford System 3500 analyzer (Gilford Instruments, Oberlin, Ohio).
[0214]For the entire genomic sequence of APOAV, overlapping sequence-tagged sites (STSs) of 400-498 bp in size were designed and tested using PCR-amplification on human genomic DNA as previously described in E. M. Beasley, R. M. Myers, D. R. Cox, L. C. Lazzeroni, PCR Applications (Academic Press, San Diego, Calif., 1999). Only primer pairs that resulted in a single PCR product of expected size were used for subsequent amplifications. For SNP discovery, STSs were PCR-amplified from eight samples of the Polymorphism Discovery Resource panel (PDR08, Coriell Cell Repository, Camden, N.J.), and products were purified through Millipore plates according to the manufacturer's recommendations (Millipore, Bedford, Mass.). Subsequent sequencing reactions with purified PCR products were performed using Big Dye Terminator chemistry and forward or reverse primers in separate sequencing reactions (Applied Biosystems, Foster City, Calif.).
[0215]Reactions were analyzed using a 3700 Sequence Analyzer (Applied Biosystems, Foster City, Calif.). Sequence traces were automatically analyzed using PhredPhrap and Polyphred (D. A. Nickerson, V. O. Tobe, S. L. Taylor, Nucleic Acids Res 25, 2745-51 (1997); B. Ewing, P. Green, Genome Res 8, 186-94 (1998)). For SNPs identified through this analysis, PCR INVADER assays (Third Wave Technologies, Madison, Wis.) were designed and tested on 90 samples from the Polymorphism Discovery Resource panel (PDR90) (C. A. Mein, et al., Genome Res 10, 330-43 (2000)). Successful assays were subsequently used to analyze samples from our study. Genotypes were assigned automatically by cluster analysis. Differences among genotypes were analyzed by one way ANOVA using STATVIEW 4.1 software (Abacus Concepts, Inc., Berkeley, Calif.).
[0216]To genotype the C/T SNP3 polymorphisms upstream of APOAV (discussed in Example 5), oligonucleotides AV6-F-5'-GATTGATTCAAGATGCATTTAGGAC-3' (SEQ ID NO:20) and AV6-R-5'-CCCCAGGAACTGGAGCGAAATT (SEQ ID NO:21) were used to amplify a 187 bp fragment from genomic DNA. The penultimate base in AV6-R was changed to T to create a MseI site (TTAA) in the common allele. The PCR reactions were performed in 20 μl volumes containing 50 mmol/l KCl, 10 mmol/l Tris (pH 8.3), 1.5 mmol/l MgCl2, 0.2 mmol/l of each dNTP, 1 U of Taq, DNA polymerase and 200 pmol/l of each primer. DNA was amplified using the following conditions: initial denaturation of 96° C. for 2 min, followed by 32 cycles of 94° C. for 15 sec, 55° C. for 30 sec and 72° C. for 30 sec, and a final step at 72° C. for 3 min. 20 μls of PCR product were digested with 10 U of MseI (New England Biolab) at 37° C. for 3 h. The PCR products were size-fractionated on 3% agarose gels, stained with ethidium bromide and visualized on a UV transilluminator.
EXAMPLE 5
[0217]Human APOAV Polymorphisms and Lipid Association Studies
[0218]Referring now to FIG. 5, plasma lipid concentrations for a given genotype for four neighboring SNPs (SNPs1-4) are shown in Table 5A. For that study, 501 individuals were genotyped and the number of successfully scored individuals is approximately 430. The number of individuals of each SNP genotype is shown in row "n". In the row labelled "Genotype," 1,1=homozygous for the major allele; 1,2=heterozygous for the major and minor alleles. All individuals homozygous for the minor alleles of individual APOAV SNPs1-3 were removed from the analysis (n=2) to prevent their over-representation. All sites were found to be in Hardy-Weinberg equilibrium (data not shown). The minor allele frequency for each SNP (SNPs1-4) was 9.1, 8.4, 9.2 and 36.3%, respectively. Not shown is the lack of association between each of the four SNPs and IDL-, LDL-, HDL-mass, APOAI, and APOB levels (p>0.05, data not shown) FIG. 5B shows Pair-wise measure of linkage disequilibrium (|D'|) was calculated for all combinations of SNPs 1-4. A|D'| value of 1 indicates complete linkage disequilibrium between two markers. FIG. 5C shows a summary of SNP3 genotyping data from an independent set of individuals stratified based on triglyceride levels. P values were determined by Chi-square analysis. BMI=body mass index, TG=plasma triglyceride level (mg/dl±SEM).
[0219]Plasma lipid concentrations for a given genotype for four neighboring SNPs (SNPs1-4) are shown in FIG. 5A for triglycerides, VLDL, LDL and HDL. 501 unrelated normolipidemic Caucasian individuals who had been phenotyped for numerous lipid parameters before and after consumption of high- and low-fat diets were used in this study. Subjects were a combined subset of 501 healthy, nonsmoking Caucasian individuals aged >20 years (429 men, 72 women) who had participated in previous dietary intervention protocols (R. M. Krauss, D. M. Dreon, Am J Clin Nutr 62, 478S-487S (1995); D. M. Dreonet et al., Arterioscler Thromb Vasc Biol 17, 707-14 (1997)). All subjects had been free of chronic disease during the previous five years and were not taking medication likely to interfere with lipid metabolism. In addition, they were required to have plasma total cholesterol concentrations <6.74 mmol/L (260 mg/dL), triacylglycerol <5.65 mmol/L (500 mg/dL), resting blood pressure <160/105 mm Hg, and body weight <130% of ideal. Each participant signed a consent form approved by the Committee for the Protection of Human Subjects at EO Lawrence Berkeley National Laboratory, University of California, Berkeley, and participated in a medical interview. Fasting blood samples were obtained on their usual diets, and after 4-6 weeks of consuming diets containing high fat (35-46% energy) and low fat (20-24% energy). Plasma lipid and lipoprotein measurements were performed as previously described (R. M. Krauss, D. M. Dreon, Am J Clin Nutr 62, 478S-487S (1995); D. M. Dreonet al., Arterioscler Thromb Vasc Biol 17, 707-14 (1997)). In addition, on the high and low fat diets, total mass was measured by analytic ultra-centrifugation.
[0220]Significant associations were found between both plasma triglyceride levels and VLDL mass and the three neighboring SNPs (SNPs1-3) within APOAV but not with the distant upstream SNP4 (FIGS. 1A, 4A). Specifically, the minor allele of each of these SNPs (SNPs 1-3) was associated with higher triglyceride levels independent of diet. Independent analysis of each of these SNPs (SNP1-3) revealed plasma triglyceride levels were 20-30% higher in individuals having one minor allele compared to individuals homozygous for the major allele. Analysis of SNP allele frequencies in more than 1,000 chromosomes revealed that the three neighboring SNPs (SNPs1-3) in APOAV were in significant linkage disequilibrium that does not extend to SNP4 (located ˜11 kb upstream of APOAV). This finding supports the existence of a common haplotype in the APOAV region influencing plasma triglyceride levels (FIG. 4B). Furthermore, preliminary studies in this population found no significant association of triglyceride levels with a Sst1 polymorphism in APOC3 (located ˜40 kbp upstream of APOAV) which has been previously associated with severe hyper-triglyceridemia (See M. R. Hayden, et al., Am J Hum Genet 40, 421-30 (1987), M. Dammerman, et al., Proc Natl Acad Sci USA 90, 4562-6 (1993)). All individuals homozygous for the minor alleles of individual APOAV SNPs1-3 were removed from the analysis (n=2) to prevent their over-representation. All sites were found to be in Hardy-Weinberg equilibrium (data not shown). The minor allele frequency for each SNP (SNPs1-4) was 9.1, 8.4, 9.2 and 36.3%, respectively. No association between each of the four SNPs and IDL-, LDL-, HDL-mass, ApoAI, and ApoB levels (p>0.05) was observed.
[0221]Pair-wise measure of linkage disequilibrium (|D'|) was calculated for all combinations of APOAV SNPs as previously described by R. C. Lewontin, Genetics 120, 849-52 (1988). A |D'| value of 1 indicates complete linkage disequilibrium between two markers.
[0222]A summary of SNP3 genotyping data from an independent set of individuals stratified based on triglyceride levels. P values were determined by Chi-square analysis. BMI=body mass index, TG=plasma triglyceride level (mg/dl±SEM).
[0223]In a second human association study with SNP3 in an independently ascertained cohort using a different experimental design (FIG. 5C). SNP3 was chosen for genotyping in this study based on its strong association in our first study and its apparent complete linkage disequilibrium with the other two associated SNPs (SNPs 1-2). In the second study, we examined the allele frequencies for SNP3 in an unrelated group of Caucasians stratified according to plasma triglyceride levels. The two groups represented 115 individuals with triglyceride levels in the top tenth-percentile and 183 individuals from the bottom tenth-percentile. A significant over-representation of the heterozygous genotype (SNP3, APOA5*2) was found in individuals with high- compared to low-plasma triglyceride levels (18.3% versus 8.7%, respectively), thereby validating the effect in a second cohort. When the cohort was stratified based on gender, an even more pronounced over-representation of the heterozygous genotype was found in males with high- compared to low-plasma triglyceride levels (29.4% versus 5.2%, respectively).
[0224]Individuals that carry either of two independent SNPs described above have ˜30% higher triglyceride levels. Population-wide this effect is large. 25% of Caucasians, 36% of African-Americans, and 51% of Hispanics carry at least one copy of these two alleles associated with elevated triglycerides.
EXAMPLE 6
[0225]APOAV Haplotypes: Linkage Disequilibrium and Association Studies
[0226]The present Example describes methods for establishing genetic profiles of individuals carrying various alleles of the present APOAV gene. These methods rely on Linkage Analysis studies and result in the identification of haplotyes including the SNP's described in connection with FIG. 5. The haplotypes are illustrated in FIG. 4B and are APOA5*1, APOA5*2 and APOA5*3.
[0227]The present study protocols were approved by the appropriate institutional review boards. Fasting blood samples were obtained from i) 116 hyperlipidemic patients including 34 with Type III hyperlipidaemia, 10 with familial combined hyperlipidemia, 24 with LDL cholesterol levels exceeding the 90th percentile, and 48 patients with plasma triglyceride levels exceeding 500 mg/dl; ii) 82 Caucasian men and 50 Caucasian women who were homozygous for the common allele of SNP3 (-1131T) and who had plasma triglyceride concentrations above the 90th percentile for age and sex, and an equal number who were homozygous for the common allele of SNP3 (-1131T) and had plasma triglyceride concentrations below the 10th percentile for age and sex; and iii) 2660 residents of Dallas County selected at random from census tracts who participated in the Dallas Heart Disease Prevention Project (DHDPP), a population-based study of atherosclerotic heart disease.
[0228]DNA samples were also obtained from healthy, nonsmoking, Caucasian men (n=354) and women (n=65) who had participated in previous dietary intervention protocols and had plasma cholesterol levels below 260 mg/dl and plasma triglyceride levels below 500 mg/dl.
[0229]DNA sequencing: The exons and flanking intron sequences of the APOAV gene were screened for sequence polymorphisms by DNA sequencing. DNA fragments of ˜400 basepairs spanning each exon were PCR amplified and sequenced using Big Dye Terminator Cycle Sequencing reagents on an ABI3100 automated sequencer.
[0230]SNP genotyping: The SNP5 (S19W) and V153M polymorphisms were assayed using PCR-RFLP and PCR INVADER assays (Third Wave Technologies, Madison, Wis.) as described previously. All PCR primers and probes used in biplex INVADER assays for this study are listed in Table 4. To assay the SNP5 polymorphism, oppositely-oriented oligonucleotides (AV1-F 5' TGCTCACCTGGGCTCTGGCTCTTC (SEQ ID NO:24) and AV1-R 5' CCAGAAGCCTTTCCGTGCCTGGGCGGC (SEQ ID NO:25)) were designed with a single nucleotide mismatch such that the C to G substitution that changes codon 19 from serine to tryptophan creates an Eag I site. PCR was performed in 20 μl volumes containing 50 mM KCl, 10 mM Tris (pH 8.3), 1.5 mM MgCl2, 0.2 mM of each dNTP, 1 U of Taq DNA polymerase and 200 pM of each primer. Reactions were performed in a PTC-200 Thermal cycler (MJ Research, South San Francisco, Calif.) using an initial denaturation step of 96° C. for 2 min, followed with 30 cycles of 94° C. for 15 sec, 70° C. for 20 sec and 72° C. for 30 sec. The PCR products were digested for 3 hr at 37° C. with 7 U of Eag I (New England Biolabs, Beverly, Mass.) in buffer provided by the manufacturer and analysed by electrophoresis in 3% agarose gels. For the V153M polymorphism, genomic DNA was amplified using the oligonucleotides AV150-R 5' TGGTGCACCACGAGGCTCTGCAGCAGTCCC (SEQ ID NO:26) and AV150-F 5' AGGTGGCCCTGCGAGTGCAGGAGCTGC (SEQ ID NO:27) as described above, except that the annealing temperature was 67° C. PCR products were digested with Nla III and assayed by electrophoresis in 3% polyacrylamide gels.
[0231]The SNP3 polymorphism was analyzed by mass spectrometry using the MASSARRAY system (Sequenom Corporation, San Diego, Calif.) (Buetow et al. 2001, Proc. Natl. Acad. Sci. U.S.A 98 (2):581-584). The oligonucleotides used in biplex INVADER genotyping assays (Sequenom Corporation, San Diego, Calif.) are shown in Table 4 below and are SEQ ID NOS: 28-36. The polymorphisms SNP5, SNP6, and V153M (location shown in FIG. 4A) are available in dbSNP under accession numbers ss4383597, ss4383596, and ss4383598, respectively and in GenBank under rs3135506 (SNP5), rs651821 (SNP6), and rs3135507 (V153M).
TABLE-US-00004 TABLE 4 SNP Sequence SEQ ID NO: 28 SNP 6 Probe 1 ATG ACG TGG CAG ACG TAA TGG CAA GCA TGG C SEQ ID NO: 29 Probe 2 CGC GCC GAG GAT AAT GGC AAG CAT GGC SEQ ID NO: 30 Invader GCC TCC CTC CAC CTG TCT TCT CAG AGC AGT SEQ ID NO: 31 SNP5 Probe 1 ATG ACG TGG CAG ACG AAA ACG CTG TGG AGA G SEQ ID NO: 32 Probe 2 CGC GCC GAG GCA AAA CGC TGT GGA GAG SEQ ID NO: 33 Invader GCC TTT CCG TGC CTG GGT GGC CT SEQ ID NO: 34 V153M Probe 1 ATG ACG TGG CAG ACG TGG TGG GGG AAG AC SEQ ID NO: 35 Probe 2 CGC GCC GAG GAT GGT GGG GGA AGA C SEQ ID NO: 36 Invader AGG AGC TGC AGG AGC AGT TGC GCT
[0232]Statistical Analysis: Statistical analyses were carried out using the SAS computer program (Cary, N.C.). Plasma triglyceride concentrations were compared among different genotype groups using Wilcoxon's test. Allele frequencies were compared using Fisher's exact test. To determine pairwise linkage disequilibrium (LD) between SNPs, haplotype frequencies were estimated for 353 unrelated individuals using the Expectation-Maximization (EM) algorithm implemented in the computer program ARLEQUIN v. 2.0 (Excoffier and Slatkin, Mol. Biol Evol. 1995, 12 (5):921-927). The resulting frequencies were used to calculate the pairwise LD parameter D' as discussed by Lewontin (Genetics 1988, 120 (3):849-852).
[0233]DNA sequencing: Screening of the coding regions and intron-exon boundaries of APOAV in 116 hyperlipidemic individuals revealed 10 new DNA sequence variations (FIG. 1A). An A to G substitution 3 nucleotides upstream of the initiation codon (SNP6) was found to be in strong linkage disequilibrium with three previously described polymorphisms (SNP1, SNP2, SNP3, FIG. 1A) that define the APOA5*2 haplotype which is associated with increased plasma triglyceride concentrations (Pennacchio et al., 2001 Science 294 (5540):169-173). The A to G substitution results in a conservative change in the predicted Kozak consensus sequence (SNP6) (Kozak 1991, J Cell Biol 115 (4):887-903; Kozak, Cell 1986, 44 (2):283-292). Two common nonsynonymous substitutions were also identified: A C→G substitution (SNP5) changed codon 19 from serine to tryptophan in 23 individuals, and a G→A substitution (c.457G>A) changed codon 153 from valine to methionine in 14 individuals. A third nonsynonymous substitution (c.944C>T) that changed codon 315 from alanine to valine was identified in two hyperlipidemic individuals. This conservative substitution did not co-segregate with hyperlipidemia in the family members of one of these individuals (data not shown) and was not found in 108 normolipidemic individuals, therefore no further studies of this polymorphism were undertaken. The other six polymorphisms, including three silent substitutions (c.132C>A, c.695C>G, c.738C>T), and three polymorphisms each found only in single individuals (IVS2+55G>C, and c. 1132C>T and c.1156 G>A in the 3' UTR) were not evaluated further.
[0234]Allele frequency and Linkage Disequilibrium: Five polymorphisms were found to define three common haplotypes (denoted APOA5*1, APOA5*2, and APOA5*3) in 419 unrelated Caucasian individuals (FIG. 4B). These three haplotypes represented 82%, 8%, and 8% of the APOAV chromosomes examined, and thus comprise more than 98% of APOAV haplotypes in this population. APOA5*2 is distinguished from the common haplotype (APOA5*1) by four nucleotide substitutions (-1131T>C, c.-3A>G, IVS3+476G>T, and c.1259T>C) and shown to be associated with increased plasma triglyceride levels and named SNP3, SNP6, SNP5, SNP2 and SNP1 respectively. APOA5*3 is distinguished from the common haplotype by the substitution of G for C at nucleotide c.56 (codon 19 in the amino acid sequence). To determine the relative frequencies of the APOA5*2 haplotype in African-Americans and Hispanics, the -1131T>C SNP5 polymorphism was assayed in 1031 randomly selected individuals, including 545 African-Americans, 152 Hispanics, and 334 Caucasians. The allele frequency was significantly higher in African-Americans (0.12) and Hispanics (0.12), than in Caucasians (0.06, P<0.001). The frequency of the W19 allele (which defines haplotype APOA5*3) was similar in African-Americans (0.07) and Caucasians (0.06), but was substantially higher in Hispanics (0.15, P<0.001 compared to African-Americans).
[0235]Using this mathematical calculation specifically for SNP6 (APOA5*2) where the minor allele frequency is 6% in Caucasians, we find the distribution is 88% homozygous major, 11.6% heterozygous, 0.4% homozygous minor. Similarly, for SNP5(APOA5*3) the minor allele frequency is 6% for Caucasians, thus the distribution is 88% homozygous major, 11.6% heterozygous, 0.4% homozygous minor. Therefore, because SNP5 and SNP6 are independent of each other, 23.2% of the population is heterozygous (because 11.6%+11.6%=23.2%) and an additional 0.8% are homozygous for the minor allele. Thus, a large number (24%) of individuals in the general Caucasian population have elevated triglyceride levels solely due to the effect of APOAV polymorphisms.
[0236]In addition to APOAV's strong association with triglyceride levels in Caucasians, a strong effect is also seen African-Americans and Hispanics where the minor allele frequencies are higher. Thus, a larger percent of African-Americans and Hispanics display increased triglycerides due to the genetic effect of APOAV. Specifically, APOA5*2 and/or APOA5*3 are present in 36% of African Americans and 51% of Hispanics and results in an ˜25% increase in triglycerides compared to APOA5*1 homozygotes.
[0237]For SNP6 (APOA5*2) in Hispanics and African-Americans, the minor allele frequency is 12% thus the distribution is 77.4% homozygous major, 21.1% heterozygous, 1.4% homozygous minor. For SNP5 (APOA5*3) in Hispanics, minor allele frequency is 15%. Thus the distribution is 72% homozygous major, 25.5% heterozygous, 2.3% homozygous minor. For African-Americans, SNP5 (APOA5*3) minor allele frequency is 7% thus the distribution is 86.7% homozygous major, 13.0% heterozygous, 0.5% homozygous minor. Thus, for Hispanics 23.5% of individuals carry APOA5*2 and 27.8% carry APOA5*3 for a total of 51.3% of Hispanics carry minor versions of APOAV associated with increased triglycerides. Using a similar logic, 36% of African-Americans carry minor versions of APOAV associated with increased triglycerides.
[0238]Abnormalities in APOAV may be solely responsible for human genetic forms of cardiovascular disease (similar to APOE or APOAI) in certain families and individuals. By screening this gene in families with individuals segregating cardiovascular or other types of disease, causative mutations may be found. This would have important diagnostic implications as well as provide therapeutic entry points. Furthermore, the data indicate that alleles in this gene are associated with increased plasma triglyceride levels thereby likely predisposing large numbers of individuals to increased susceptibility to coronary artery disease. A second implication of our findings is that this gene has sequence variations or single nucleotide polymorphisms that correlate to increased susceptibility to cardiovascular disease. The minor alleles of the polymorphisms disclosed herein associated with triglycerides occur in approximately 25% of the Caucasian population, 36% of African-Americans and 51% of Hispanics, thus representing a significant cross-section of the population. There is an approximate 25% chance that a Caucasian person is heterozygous for one or both of the two rare haplotypes and individuals having this rare allele have 20-30% higher triglyceride levels. Furthermore, the present studies suggest that the rare allele at the SNP5 locus (or any polymorphism in linkage disequilibrium with it) may have a major impact on plasma triglyceride levels in those persons predisposed to hypertriglyceridemia. Therefore, finding and exploring the significance of DNA sequence polymorphisms in APOAV and its subsequent effect on plasma triglyceride levels in humans is another important diagnostic implication of this embodiment.
[0239]Association Studies: To test for association between the two common, nonsynonymous polymorphisms identified in this study (SNP5 and V153M) and plasma triglyceride concentrations, the allele frequencies at these loci were compared in Caucasian men and women who had plasma triglyceride concentrations above the 90th percentile or below the 10th percentile for age and sex. To eliminate confounding by the APOA5*2 haplotype that was previously associated with high plasma triglyceride levels, individuals who carried this haplotype were excluded. In both sexes, the rare allele at codon 19 (W19) was significantly more common in individuals with plasma triglyceride levels above the 90th percentile than in those with plasma triglyceride levels below the 10th percentile (Table 5). Since individuals with the SNP3 allele were excluded, the association between the S19W (SNP5) polymorphism and plasma triglyceride concentrations is independent of the APOA5*2 haplotype that was previously shown to be associated with increased plasma triglyceride levels (Pennacchio et al. 2001).
[0240]The study showing the relationship between gender, genotype and triglyceride levels looked at men and women with high (>90th percentile) and low (<10th percentile) plasma triglyceride concentrations and is shown below.
TABLE-US-00005 TABLE 5 APOAV genotype S19/S19 S19/W19 W19/W19 P value Men TG < 10th percentile 74 7 1 <0.005 (n = 82) (90.5) (8.5) (1) Men TG > 90th percentile 63 19 0 (n = 82) (77) (23) (0) Women TG < 10th percentile 50 0 0 <0.001 (n = 50) (100) (0) (0) Women TG > 90th percentile 39 11 0 (n = 50) (78) (22) (0)
[0241]Values are numbers of individuals in each group. S19 is the common allele of SNP5. The percentage of individuals with the genotype is given in parentheses. All individuals were homozygous for the common alleles at SNPs 3, 6, 2 and 1, which means that all individuals with APOA5*2 haplotype were excluded. P values were calculated using Fisher's exact test.
[0242]To further assess this association, the SNP5 polymorphism was assayed in 419 healthy independently-ascertained Caucasians (354 men and 65 women). Baseline blood samples were obtained from these individuals on their self-selected diets, and additional samples were drawn following the consumption of a defined high-carbohydrate or high-fat diet. On all three diets, individuals who were heterozygous for the SNP5 (W19) allele and who lacked haplotype APOA5*2 had significantly higher plasma triglyceride concentrations than did individuals homozygous for the S19 (wild type) allele (Table 5).
[0243]The increase in mean plasma triglyceride levels associated with a single copy of the W19 allele was ˜36%, which is similar to the increase in triglyceride levels associated with APOA5*2 haplotype (˜32%) in these individuals. To determine if the W19 allele was associated with increased plasma triglyceride concentrations in other ethnic groups, the S19W polymorphism was assayed in a random sample of 1392 African-American, 420 Hispanic, and 848 Caucasians. In both sexes of all three ethnic groups, both the mean and the median plasma triglyceride concentrations were higher in W19 heterozygotes than in S19 homozygotes (Table 6 below). The difference was significant at the 0.05 confidence level for African-Americans and Caucasians in both sexes, but did not achieve the nominal significance threshold in Hispanics, presumably due to the smaller sample size in this group.
TABLE-US-00006 TABLE 6 Plasma triglyceride levels (mg/dl) S19/S19 S19/W19 W19/W19 P Value African- Mean ± S.D. 101 ± 169 131 ± 120 141 ± 50 0.0023 American Median ± I.Q. 80 ± 59 97 ± 85 192 Women range n (707) (108) (6) African- Mean ± S.D. 132 ± 152 176 ± 319 264, 84 0.024 American Median ± I.Q. 94 ± 84 111 ± 92 Men range n (494) (75) (2) Hispanic Mean ± S.D. 143 ± 95 174 ± 209 394 ± 534 0.057 Women Median ± I.Q. 119 ± 92 135 ± 99 214 range n (185) (57) (7) Hispanic Mean ± S.D. 173 ± 139 204 ± 182 206, 124 0.087 Men Median ± I.Q. 139 ± 108 157 ± 101 range n (119) (50) (2) Caucasian Mean ± S.D. 124 ± 96 147 ± 90 237, 125 0.012 Women Median ± I.Q. 100 ± 87 122 ± 110 range n (386) (54) (2) Caucasian Mean ± S.D. 161 ± 121 255 ± 225 0.0012 Men Median ± I.Q. 126 ± 116 183 ± 237 range n (362) (44) (0)
[0244]The nucleotide substitution (c. 457G>A, ) that changed codon 153 from valine to methionine was less common in men with high plasma triglyceride levels (3/82) than in men with low plasma triglyceride levels (7/82), but this difference was not statistically significant (P=0.12, Fisher's exact test). In 388 healthy Caucasian individuals, the mean plasma triglyceride level of 457G homozygotes was similar to that observed in 457GA heterozygotes (126.2±4.2 mg/dL (n=363) and 113.3±12.7 mg/dL (n=25), respectively, p=0.43).
EXAMPLE 7
[0245]Haplotype Linkage of APOAV Rare Alleles to Hyperlipidemia (CHL) and Familial Combined Hyperlipidemia (FCHL) Diseases
[0246]Familial combined hyperlipidemia (FCHL) is a common disorder of lipid metabolism affecting 1-2% of individuals in Western society. The term FCHL was coined by Goldstein et al (1973) to describe a pattern of lipid abnormalities in 47 Seattle pedigrees, ascertained through survivors of myocardial infarction who had raised blood cholesterol and triglyceride levels. Herein, APOAV allele SNP6 (c.56G) is shown to have an increased transmission in affected FCHL members from large pedigrees.
[0247]This example involves linkage and linkage disequilibrium (LD) tests on the APOA1/C3/A4/A5 genomic interval in a substantial cohort of white British families with FCHL. The results show that the transmission of FCHL in a subset of these families is linked to the transmission of two independent haplotypes in the APOA1/C3/A4/A5 genomic interval. The first haplotype contains the rare allele at the SNP5 locus and a second the rare allele at the APOC3c.386C>G locus within the APOC3 (or "APOCIII") gene.
[0248]To establish the contribution of allelic variation at the APOA1/C3/A4/AS genomic interval to FCHL susceptibility, linkage and LD tests were performed on a cohort of white British families. For the linkage test, 86 extended families were genotyped with two markers: D11SAPOC3 which resides within the third intron of the APOC3 gene, and D11S1998, which is located approximately 1.7 Mbp downstream of the APOAV gene (FIG. 1). The families contained 177 and 270 affected relative pairs for the CHL phenotype and the triglyceride trait of FCHL, respectively. The D11SAPOC3 marker produced nominal evidence for linkage (NPL.sup.+ 1.72, P=0.042) of the chromosome 11q23 genomic region to the triglyceride trait of FCHL, and this was attributable to an excess of allele sharing in the affected pedigree members of a subset (i.e. 35) of the 86 families.
[0249]To substantiate evidence for linkage of the APOA1/C3/A4/A5 genomic interval to FCHL, we performed a PDT on 115 white British families using seven SNPs that span an interval of 108 Kbp, followed by a case-control study involving 181 white British probands and 268 pedigree founders. The "PDT," pedigree disequilibrium test, is described at "A Test for Linkage and Association in General Pedigrees: The Pedigree Disequilibrium Test" by Martin E R, Monks S A, Warren L L, and Kaplan N L. Am J Hum Genet 67:146-154, 2000. For a discussion of the SNP naming conventions used in this Example, see Antonarakis et al. "Recommendations for a nomenclature System for Human Gene Mutations," Human Mutation 11:1-3 (1998).
[0250]The SNPs are named using the annotation described previously, "IVS" means that the SNP is positioned in the intervening sequence, "c" means the SNP is positioned in the coding sequence, "-" indicates the location is upstream by a specified number of base pairs, and "+" indicates that the location is downstream by a specified number of base pairs.
[0251]The SNPs included two SNPs within the APOAV gene (SNP5 (APOA5c.56C>G) and SNP6 (APOA5c.-3A>G)), a noncoding SNP within the APOC3 gene (APOC3c.386C>G), three SNPs upstream of the APOAV locus (SNP3 (APOA5-1,131T>C), SNP4 (APOA5-12,238T>C), and APOA1-3031C>T) and one SNP (APOA5.sup.58,892C>T) downstream of APOAV.
[0252]The results of the PDT produced evidence for increased transmission of the rare alleles at the SNP5 and APOC3c.386C>G loci to affected subjects. For example, the rare alleles at the SNP5 and APOC3c.386C>G loci were respectively transmitted 1.95- and 1.45-fold more frequently to affected family members with the triglyceride trait of FCHL than an unaffected child individuals. The corresponding values for the CHL trait were 1.95 and 1.33, respectively. The rare alleles at the SNP6 and SNP3 loci were also transmitted 1.28 and 1.40 fold-more frequently to affected individuals with the CHL phenotypes of FCHL than to unaffected individuals (P=0.039 and 0.033).
[0253]The rare alleles at the SNP5, APOC3c.386C>G, SNP3 and SNP6 loci were also present at increased frequencies in FCHL probands versus pedigree founders (i.e. "married ins"). For example, the rare allele at the SNP5 locus was present in 21% of the probands compared to 13% of the normolipidemic pedigree founders, whereas the rare allele at the APOC3c.386c>G locus was present in 29% of the probands and 15% of the normolipidemic pedigree founders. Importantly, the results from this case-control study and the PDT complemented each other. For the example, the frequencies of the rare alleles at the SNP5, SNP6, SNP3 and APOC3c.386C>G loci in FCHL probands and affected FCHL sibs were remarkably similar (i.e. 0.1200, 0.1144, 0.1111 and 0.1486, respectively versus 0.1114, 0.1156, 0.1296 and 0.1566). Likewise, the frequencies of the rare alleles at the SNP6 and APOC3c.386C>G loci were similar in the pedigree founders and unaffected sibs (0.0694 and 0.1024, respectively versus 0.0511 and 0.1048) (Table 2). Thus, the case-control data support the evidence that the rare allele at SNP5 (APOA5c.56G) and APOC3c.386G alleles (or alleles in LD) are preferentially transmitted in FCHL.
[0254]Probands with the rare allele at SNP5 (APOA5c.56G) had higher mean triglyceride levels than probands homozygous for the major allele at this locus, and this was particularly evident in those individuals that were homozygous for this rare allele (n=5). Thus, mean plasma triglyceride levels in probands with the APOA5c.56G allele were on average 2.2 fold higher than in probands homozygous for the common SNP5 (APOA5c.56C) allele, and ˜1.8 fold higher relative to the heterozygote probands. By contrast, the APOA5c.56G allele had no major impact on triglyceride levels in heterozygote pedigree founders, and this was also the case when all individuals with the rare allele at the APOC3c.386C>G locus were excluded from the analyses (data not shown). Only one pedigree founder was homozygous for the APOA5c.56G allele, precluding an assessment of the impact of the homozygous state of this allele (or an allele in LD) on plasma triglyceride in the pedigree founders of white British families with FCHL.
[0255]The APOC3c.386G allele (or an allele in LD) had a modest impact on triglyceride levels in probands and pedigree founders. On average pedigree founders with the APOC3c.386G allele had plasma triglyceride levels that were 31% higher than pedigree founders without this allele (P=0.001), and this increased to a value of 38% (P=0.001) when we considered only those individuals with the common allele at the SNP5 locus (data not shown). Similar increases in plasma triglyceride levels were also observed in pedigree founders with the rare alleles at the SNP3 and SNP6 loci (data not shown). In a complementary analysis, increased frequencies of these rare alleles were observed in pedigree founders that had plasma cholesterol and triglyceride levels >75th percentile age-sex-specific values relative to the rest. This trend was not observed for the rare allele at the APOA5c.56C>G locus, indicating that this allele resides on a different APOA1/C3/A4/A5 haplotype than the rare alleles at the APOC3c.386C>G and SNP3 and SNP6 loci.
[0256]To further test for preferential transmission of the APOA5c.56G and APOC3c.386G alleles in FCHL, a second study repeated the PDT in families with haplotype data for the APOA1/C3/A4/A5 genomic interval. The distorted transmission of the rare allele at the SNP5 locus in FCHL was restricted to the 35 families that produced evidence for linkage of the chromosome 11q23 locus to FCHL (P=0.0133), suggesting that a major component of this observed linkage may be explained by this allele, or a polymorphism in LD with it or a linked allele. By contrast, the rare alleles at the APOA5.sup.58892C>T, SNP6, SNP3 and APOC3c.386C>G loci were only modestly over-transmitted in the 35 families that had contributed to the nominal evidence of linkage of FCHL to chromosome 11q23 (P=0.0423, 0.12, 0.19, 0.079, respectively), indicating supporting that these alleles, or alleles in LD with them, may have contributed at most very modestly effects to the observed linkage signal.
[0257]The results of the case-control study, included genotype data from 181 white probands and 268 pedigree founders, and essentially mirrored the results of the PDT. Thus, the frequencies of the rare alleles at the SNP5, APOC3c.386C>G, SNP3 and SNP6 loci were increased in FCHL probands versus pedigree founders. For example, the rare allele at the SNP5 locus was present in 21% of the probands compared to 13% of the normolipidemic pedigree founders (P=0.01), whereas the rare allele at the APOC3c.386C>G locus was present in 29% of the probands and 14.8% of the normolipidemic pedigree founders (P=0.01). The corresponding values for the rare alleles at the SNP3 and SNP6 loci were 20.5% and 6.4% (P=0.001), and 21.6% and 8.6% (P=0.001), respectively.
[0258]Probands with the rare allele at the SNP5 locus had higher mean triglyceride levels than probands homozygous for the major allele at this locus, and this was particularly evident in those individuals that were homozygous for this rare allele. Thus, mean plasma triglyceride levels in probands with the rare allele at the SNP5 locus were on average 2.2 fold higher than in probands homozygous for the common allele at this locus, and ˜1.8 fold higher than those found in the heterozygote probands. By contrast, the rare allele at the SNP5 locus had no major impact on triglyceride levels in heterozygote pedigree founders, and this was also the case when all individuals with the rare allele at the APOC3c.386C>G locus were excluded from the analyses. Only one pedigree founder was found to be homozygous for the rare allele at the SNP5 locus, and this has precluded us from establishing the impact of the homozygous state of this allele (or polymorphisms in LD with it) on plasma triglyceride in the pedigree founders. Nonetheless, the inventors suggest that the rare allele at the SNP5 locus (or any polymorphism in LD with it) may have a major impact on plasma triglyceride levels in those persons predisposed to hypertriglyceridemia.
EXAMPLE 8
[0259]Modulating and Regulating APOAV Expression with Drugs
A. Human APOAV Gene Expression Induced by Fibrates Treatment
[0260]Fibrates are described at Miller D B, Spence J D. "Clinical pharmacokinetics of fibric acid derivatives (fibrates). Clin Pharmacokinet 1998; 34(2):155-62. To determine whether fibrates can modulate APOAV gene expression in humans, first, analyze APOAV mRNA levels in primary hepatocytes upon treatment with a fibrate such as fenofibric acid, the active form of fenofibrate, which is a prototype of PPARα ligands. Observe whether treatment with fenofibric acid at a concentration (100 μM) similar to that reached in plasma from patients treated with fenofibrate dramatically increases APOAV mRNA levels. These observations could demonstrate that fibrates induce the expression of the human APOAV, thus supporting the use of APOAV as a new target gene for fibrates. In general, a drug candidate may be tested in cells or animals and the effect of that drug on levels of APOAV mRNA and/or protein observed. Drug candidate which increase such levels have utility as agents which may lower cholesterol and triglyceride levels in appropriate subjects. As described in connection with Example 9, a drug candidate may also have insulin modulating properties which can be measured through the effect of a drug candidate on protein and/or mRNA levels of APOAV in a test animal or cell. Furthermore, which it is shown by the present work that increased levels of APOAV are associated with lowered levels of triglycerides and cholesterol, for individuals having deleterious alleles, lowering APOAV levels may be beneficial.
B. Fenofibrate Regulation of apoA5 Expression Via PPARα Activation
[0261]Next, one could examine whether PPARα is involved in the regulation of apoa5 by fibrates. Apoa5 mRNA levels could be strongly enhanced in the liver of wild-type mice after treatment with fenofibrate mixed in diet (0.2% w/w). These experiments would show that apoa5 expression is induced by fibrates in vivo in mouse liver and its regulation may largely depend on PPARα activation.
C. Gene Regulation of APOAV by Fibrates at the Transcriptional Level
[0262]To delineate the mechanism of regulation of APOAV gene expression by fibrates, functional analysis of the APOAV promoter is necessary. Host cells, such as HepG2 cells, can be transiently transfected with a Luciferase reporter vector driven by the human APOAV promoter and challenged with a PPARα activator. Transcriptional activity of the APOAV reporter construct can be observed for increase in levels after addition of the activator. Co-transfection with PPARα may also have the effect of strongly stimulating APOAV promoter activity. Such results would indicate that the gene regulation of APOAV by fibrates occurs at the transcriptional level.
D. APOAV Responsiveness to PPARα or PPARγ
[0263]Transcriptional activation of APOAV gene by PPARα would suggest the presence of a peroxisome proliferator-activated response elements (PPRE) in the APOAV promoter sequence. Comparative sequence analysis of the murine and human APOAV promoters can be performed to reveal the presence of any regions of cross-species conservation containing putative PPREs with a high degree of homology between the putative PPREs and the PPRE consensus defined for PPARs.
[0264]To assess whether the putative PPREs mediate any PPARα or PPARγ effects, one should perform transfection experiments using a promoter construct containing mutated versions of any PPREs found. If mutation of any PPREs found abolishes activation of the APOAV promoter by PPARα this would indicate that the human APOAV promoter contains PPREs that act to mediate PPAR action.
EXAMPLE 9
[0265]APOAV Expression Levels and Their Effect Upon Human Insulin Levels
[0266]Significant differences in plasma triglyceride concentrations in APOAV genetically engineered animals prompted study to determine if alterations in APOAV expression led to changes in plasma glucose or insulin levels as well. Significant differences were also found for plasma insulin but not glucose levels. APOAV transgenic mice were found to have ˜80% higher insulin levels than controls, compared to ˜220% lower insulin levels in apoA5 knockouts compared to controls. P-values were calculated based on student T-tests. Plasma glucose levels were also examined and no differences were found. Their levels were 173, 166, 132, and 130 mg/dL in ApoA5 transgenics, littermate controls, apoA5 knockouts, and littermate controls, respectively.
TABLE-US-00007 TABLE 7 Plasma Triglyceride and Insulin Concentrations in ApoA5 Transgenic, ApoA5 Knockout and Littermate Control Mice Insulin Triglycerides ng/ml (S.E.M.) p value (S.E.M.) p value Control (FVB) 152.9 (±6.3) 0.000015 0.9 (±0.07) 0.01 APOA5 90 (±7.6) 1.6 (±0.29) Transgenic (FVB) Control 150.3 (±26.1) 0.025 2 (±0.16) 0.0000006 (C57B16/129Sv) ApoAV Knockout 245.9 (±41.0) 0.9 (±0.06) (C57B16/129Sv)
[0267]The fact that both transgenic and knockout mice shown differences in insulin but not glucose levels indicate alterations in the function of insulin in these two models. For instance the finding of high triglycerides in APOAV transgenic (yet unchanged glucose levels) supports the hypothesis that these animals are insulin resistant.
[0268]These findings suggest that APOAV may plan an important role in metabolic syndrome, insulin resistance, obesity, and diabetes. In addition, they support that therapies directed at modulating APOAV levels or course of action may be useful for treating these common conditions in humans.
[0269]Thus there has been described in detail the making and use of the preferred embodiments of the present invention. In view of the present teachings, numerous alternatives and variations may be envisioned by one of ordinary skill in the field. Thus it is intended that the scope of protection for the present invention be limited only by the scope of the appended claims.
Sequence CWU
1
4811334DNAHomo sapiens 1gagcagagca gataatggca agcatggctg ccgtgctcac
ctgggctctg gctcttcttt 60cagcgttttc ggccacccag gcacggaaag gcttctggga
ctacttcagc cagaccagcg 120gggacaaagg cagggtggag cagatccatc agcagaagat
ggctcgcgag cccgcgaccc 180tgaaagacag ccttgagcaa gacctcaaca atatgaacaa
gttcctggaa aagctgaggc 240ctctgagtgg gagcgaggct cctcggctcc cacaggaccc
ggtgggcatg cggcggcagc 300tgcaggagga gttggaggag gtgaaggctc gcctccagcc
ctacatggca gaggcgcacg 360agctggtggg ctggaatttg gagggcttgc ggcagcaact
gaagccctac acgatggatc 420tgatggagca ggtggccctg cgcgtgcagg agctgcagga
gcagttgcgc gtggtggggg 480aagacaccaa ggcccagttg ctggggggcg tggacgaggc
ttgggctttg ctgcagggac 540tgcagagccg cgtggtgcac cacaccggcc gcttcaaaga
gctcttccac ccatacgccg 600agagcctggt gagcggcatc gggcgccacg tgcaggagct
gcaccgcagt gtggctccgc 660acgcccccgc cagccccgcg cgcctcagtc gctgcgtgca
ggtgctctcc cggaagctca 720cgctcaaggc caaggccctg cacgcacgca tccagcagaa
cctggaccag ctgcgcgaag 780agctcagcag agcctttgca ggcactggga ctgaggaagg
ggccggcccg gacccccaga 840tgctctccga ggaggtgcgc cagcgacttc aggctttccg
ccaggacacc tacctgcaga 900tagctgcctt cactcgcgcc atcgaccagg agactgagga
ggtccagcag cagctggcgc 960cacctccacc aggccacagt gccttcgccc cagagtttca
acaaacagac agtggcaagg 1020ttctgagcaa gctgcaggcc cgtctggatg acctgtggga
agacatcact cacagccttc 1080atgaccaggg ccacagccat ctgggggacc cctgaggatc
tacctgccca ggcccattcc 1140cagctccttg tctggggagc cttggctctg agcctctagc
atggttcagt ccttgaaagt 1200ggcctgttgg gtggagggtg gaaggtcctg tgcaggacag
ggaggccacc aaaggggctg 1260ctgtctcctg catatccagc ctcctgcgac tccccaatct
ggatgcatta cattcaccag 1320gctttgcaaa aaaa
133421879DNAHomo sapiens 2gagcagagca gataatggca
agcatggctg ccgtgctcac ctgggctctg gctcttcttt 60cagcgttttc ggccacccag
gcacggaaag gcttctggga ctacttcagc cagaccagcg 120gggacaaagg cagggtggag
cagatccatc agcagaagat ggctcgcgag cccgcgaccc 180tgaaagacag ccttgagcaa
gacctcaaca atatgaacaa gttcctggaa aagctgaggc 240ctctgagtgg gagcgaggct
cctcggctcc cacaggaccc ggtgggcatg cggcggcagc 300tgcaggagga gttggaggag
gtgaaggctc gcctccagcc ctacatggca gaggcgcacg 360agctggtggg ctggaatttg
gagggcttgc ggcagcaact gaagccctac acgatggatc 420tgatggagca ggtggccctg
cgcgtgcagg agctgcagga gcagttgcgc gtggtggggg 480aagacaccaa ggcccagttg
ctggggggcg tggacgaggc ttgggctttg ctgcagggac 540tgcagagccg cgtggtgcac
cacaccggcc gcttcaaaga gctcttccac ccatacgccg 600agagcctggt gagcggcatc
gggcgccacg tgcaggagct gcaccgcagt gtggctccgc 660acgcccccgc cagccccgcg
cgcctcagtc gctgcgtgca ggtgctctcc cggaagctca 720cgctcaaggc caaggccctg
cacgcacgca tccagcagaa cctggaccag ctgcgcgaag 780agctcagcag agcctttgca
ggcactggga ctgaggaagg ggccggcccg gacccccaga 840tgctctccga ggaggtgcgc
cagcgacttc aggctttccg ccaggacacc tacctgcaga 900tagctgcctt cactcgcgcc
atcgaccagg agactgagga ggtccagcag cagctggcgc 960cacctccacc aggccacagt
gccttcgccc cagagtttca acaaacagac agtggcaagg 1020ttctgagcaa gctgcaggcc
cgtctggatg acctgtggga agacatcact cacagccttc 1080atgaccaggg ccacagccat
ctgggggacc cctgaggatc tacctgccca ggcccattcc 1140cagctccttg tctggggagc
cttggctctg agcctctagc atggttcagt ccttgaaagt 1200ggcctgttgg gtggagggtg
gaaggtcctg tgcaggacag ggaggccacc aaaggggctg 1260ctgtctcctg catatccagc
ctcctgcgac tccccaatct ggatgcatta cattcaccag 1320gctttgcaaa cccagcctcc
cagtgctcat ttgggaatgc tcatgagtta ctccattcaa 1380gggtgaggga gtagggaggg
agaggcacca tgcatgtggg tgattatctg caagcctgtt 1440tgccgtgatg ctggaagcct
gtgccactac atcctggagt ttggctctag tcacttctgg 1500ctgcctggtg gccactgcta
cagctggtcc acagagagga gcacttgtct ccccagggct 1560gccatggcag ctatcagggg
aatagaaggg agaaagagaa tatcatgggg agaacatgtg 1620atggtgtgtg aatatccctg
ctggctctga tgctggtggg tacgaaaggt gtgggctgtg 1680ataggagagg gcagagccca
tgtttcctga catagctcta cacctaaata agggactgaa 1740ccctcccaac tgtgggagct
ccttaaaccc tctggggagc atactgtgtg ctctccccat 1800ctccagcccc tccctctggg
ttcccaagtt gaagcctaga cttctggctc aaatgaaata 1860gatgtttatg ataaaaaaa
1879316000DNAHomo
sapiensvariation(14695)..(14695)SNP1 polymorphic T or C 3ctcaagtaat
ccttctgcct cagcctcctg agtagctagg accacaggtg ccaccatacc 60tggctaattt
ttgtattctt tgcagagaca gggtctcgct acattgccca ggctggtatc 120gaactcctgg
gctcaagcga tcctcctgcc ttgccttctc aaagtgttgg gattacaggc 180atgagccact
gtgcccagcc tcaaaattta atgtataaag ttttccttaa tttttcttag 240cacaaaaacc
ctggccccca acaataccta gttttctcca ggccggagtc ccactctttt 300acccttttca
gagagaataa gcatctggtt ttctgctgct ttgggggtac ccagccaagt 360agagttgaag
agaacagctg cttctcaaac agactctcga ccaactgcca tatttctagt 420cccactgcca
cccactcttc cagaagaatg ttgacactaa tgtcagagca tttggagagt 480ttagtagtga
aaatcagggg ccttcttggc tttctccact gctgcttcaa aattcatgtc 540aggtgtgcct
gtcaccaccg tttgacyatt tggaagcttt ccagcttccc aaatgttgtt 600atttttgtct
ccttttctat tttccctttg ggtttatgca ttttgtaaaa agtgcacttc 660aatgccacgt
tattgagatt tcagagaaca gcagaggcta atgcatgcaa ttaatccacc 720gtccgttact
agaagtcaat cggatgctct ttagtctctc ttccccatat actagtttaa 780aagttatcca
ttctttctat tcgttttatg ggttatcctt aaaattttaa tattcttgtc 840tgacctaaca
aagtctatag ataatcaata tccctatctt tctcccgaat aatgcaaagg 900ctgctgaatg
ctttcacttt gatctctcct ttcccatttc caggttgctt cggtctgata 960ttttagttcc
tcattacttt taacacctcc tccaaagtag tcccttcatc aatagatgtt 1020tttgagccct
ccctaccatg tgataagcac tggtctaggc actgggagta cagtaggaaa 1080tgagataaac
ttggccaggt gtagggtggc ttacacctgt aatcccaaca cttttgaggc 1140cgaggcgggc
agctcgcttg agcccatgag ttcgagacca gcctgggaaa catagcgaga 1200cccccgtccc
tacaaaaaaa tataaaaatt agctgggcat ggtggtgtat gcctgtggtc 1260ctagctactc
agaagactga ggtgggagga tcatctgagc ccagggtggt cgaggctgca 1320gtgattacac
cactgcactc catcctgggc aacggtgaga ccctgtctca aaaaacaaac 1380aaacaaacaa
gcaaacaaaa cccccacaaa ctaaactatg tgtaaataca tttttgttag 1440gtagaactat
atgaaattgc cactatttga ccaattttta gtgaaaacta gtctcataag 1500tgtgtgtgtg
tgtattttca ctaatgtttt ttggatttac ctaaacgttt actaatttca 1560ttgctcccca
tgtctccttc tatcctattc cttttttctg ggttctgttt ccttttcaga 1620tttttagtag
ttcttttcag tgaggatctg tgagtggtaa actctctttc tctgaaatta 1680acttcttcct
ctcaaataat agttcacctg agtataagtc ttggttggcc attaatttcc 1740tttcagtctt
tagaaggtac attgatgata aatcagttgc cggtttaatc atgcttcgtg 1800tgtagatcat
tagtctttct ctttggttga ttttaagata tccattgcct tcagtgttct 1860gcagattcct
gtgatgtgtc ctcatttggt tgtgtgttaa tttttcctac caagactcag 1920gatgcttcct
gtacctgagg attccggtca catcttgctt caatgtttga aatttctcag 1980ccatcatctt
ttgaatattg cctcttccac agtccctgtg ttctcttcgt ggaaatccta 2040caggcatata
ttggacctcc cattctgtcc tccatgtctc ttaccgtcta ttcataccct 2100cctttttata
tttaattttt ttgagacaga gttttgctct gtggcccagg acggagtgca 2160attgcatgat
cttggctcac ggcaaactct gcctcccagg ttcaagctat tctcctgcct 2220cagtctccca
agtagctggg attacaggca tgcaccacca cgcccggcta atttttgtat 2280ttttagtaga
gacggggttt caccatattg gccaggctgg tctgaaactc ctgacctcag 2340gtgatccacc
cacctcggcc tcccaaagtg ctgggattat aggcatgagc caccatgcct 2400ggccaatatc
acccgcctcg gcctcccaaa gtgctgggat tacaggcatg agccaccgtg 2460cctggtcaat
atcctccttt ttatttctgt gattctttct gtgtgatttt ctcagatcta 2520ccttctagct
tactaattct ctctccaact gtagctaaat gtgttttata ttataatgac 2580tatatttttt
tcacttatag atgttctatt taattctctt tctttttgac aaatagaact 2640tatttcaaaa
caaacaaaag gccaggcatg gtggttcatg cctgtaatcc cagtgctttg 2700ggaggctgag
gcaggaggat tgcttgagcc caggagttca aggccagcct gggcaacata 2760gtgagatcct
ttctctacca aaaaaataaa aaatcagctg ggtgttgtgg gacactcctg 2820tagtcccaga
aactacagat tcttgggagg cagaggctgg aggattgctt gaggcagagg 2880ctggaggatt
gcttgagcct gggaggttga ggctgcagtg aactgtgatc atgccactgc 2940actctagcct
gggtgacaaa gtgagatcct gtctcaaaaa caaataaaca aacaagcaaa 3000gaaacaaaaa
aatgcttaca caggttacta ctttcttgct gggatagttt taacactgcg 3060ttaagcataa
acacctttct ttctgaaatg tatttgagat gtatattgat ttttaaaaaa 3120cccacacctc
cattaaggtc tggtgatagc agtagaaaca atgtagagtg gctccacaat 3180catatagatg
tttttggtgc gttctgagat ggagtccagg aacaccaagt aaagactgct 3240acctcacagt
ttacatctga gttcttagaa gacaagactg aaggagaaca atttgtaaca 3300agatttactt
ggcccgggtg tggtggctca cacctgtaat cccagtactt tgggagcttt 3360gggagtccga
ggtgggtgga tcacctgagg tcaggagttc aagaccagcc tggccaacat 3420ggaataaccc
ccatctctac taaaaataca aaaattagcc aggcacggtg gcacacgcct 3480gtaatcccag
ctactcagga ggctgaggca ggagaatcgc ttgaacccaa gtgactgggt 3540tgccgagagc
cgagatcacg ccactgtact ccagccaccc tgggtgacag agtgagactc 3600tgccaaaaaa
aaaaaaaaaa aaaaaaaaat acttactgtt cagaaggaga agtcataatg 3660ttgctttaaa
gaacaggtca caaaagaaag actctagaag atcttctcac ttggtgcata 3720tcaagtgtct
atttgagacc catacacttg cttaatccat gtgtttaagg caaaagtgct 3780gctgctgagc
agtaaggaat aaggtacctg ctaaccttta ccaatctaca ttttaaaatc 3840cttcttacta
cacatccaga atgagtcagc aattcttgtg tattaaaaaa caaaaacaca 3900aaacaaagta
gaggggcaac tctcttaaaa atgcagctat ccgcaaacac tgtgatacaa 3960aacgacagtc
aaggaaaggg cagcacaaac aagttcacct ggaaggaatc tgttcaaagt 4020ctctggattt
aagaacaagt tccctaaaag ctcttactta cagaagaaat cggataataa 4080atgtagctgg
aatgatggaa ttctttaagt tttcattttg ttttgggcaa ctctgtggcc 4140caggctggag
tgcagtggct tgatcacggc tcactgcagc ctcaacctcc caggctctgg 4200tgatcctccc
acctcagcct cctgagtggc tgggactaca agcatgtgtg ccaccatgct 4260aggctaattt
ttgtatttta tttttagttt tttttttttt tttttttttt ttgtagagac 4320aggttttgcc
atgttgccaa ggctggtctc aaattcctgg gttcaagtga tcctcccatc 4380tcagccttcc
aaagagctgg gattacaggc atgagctact gcacctggcc tagaattttt 4440taaaaatcac
tatctggcaa ctctcaggat aatattcgat tcaggcaagg atcatcaatg 4500aatgctaaaa
ccattgggtg aaaaattgtt gcagaatggg atgctcacat ggcttcaaag 4560tattgctcca
caaattactt atcaataacg taaaaaacca aactttacta gccatggaga 4620aatctggttg
ttatcacttt aatggagtga tcaaacttaa catcactaaa tagagtgcaa 4680cctccagcta
ggatacagta agaagggcca gatatcacct agtatttttg ccaaaaatgt 4740ttaaccttaa
tctaatcatg agaaagtaat cactcaaatc cagaatgtgg gacattttac 4800aagatgtcct
ccttgcactc ttccaaaaaa aaatcaatgt catgaaaaca aacaaatggt 4860ggggttgggg
agaacggttc taaatttaaa aactaaagtg ggataacaac cagatgagat 4920gtgttagagc
ttgaatttac agagagagaa aaacaactat gaaagcattt tggggaaaat 4980ctgaatatgt
aggatatgtt agatgatatt aaggaattgt gttaattttc aaaggtatga 5040taatgttttt
ttcttttgta aaagagtcct tatttttcac aatgtatgtt gaagtattca 5100gagtgaagtg
tcatgttggc tataattatt tcaaatggtt ccacacacaa agcacatacc 5160acatacacat
atacatatac ctccaaccaa ctcaaaacat gttcaacact gaaactataa 5220gatgccacca
aacagggaag catgagtgtg tgttgcatct acccattgta tcaatccagg 5280ttcagtcaga
aaaacaaaag ccattccacg tatttcaagc atgaaaggct ttaaaacaaa 5340aaattaaagg
tttatccaac tcttggaagg gctggaggag tgaccacctt ggtttgcagt 5400tcagaaggag
tgactctcaa acgctcatta gtaagtggct acaaatggga agctcgcctt 5460attatgcctg
caatatcaat gcatgtgatt cctgggaagg tcacccagaa gctgctttaa 5520actccaagcc
tgtccatgct tctgtctgca accggcattg aaacataatg gcctctcctc 5580ttccgtctca
cgctggctga ctctaaccta ggctcatata gagaagggat tctagaaaat 5640gtattaatag
ttccaagtgt cccctctgca tctcataaaa gaccttagaa agggcactga 5700taatgctatt
tgcaaaaaga caatccagcg cagttgtatt ttacagcaca ggctctttaa 5760gtttgggtta
tcagcaaaaa accattagag tatgagaaat tcctttttaa attgtggcaa 5820aatatacata
acataaaaat taccattgta gctattgtac attgtagcta agtatatagc 5880ccagtagcac
taaatacatt tacactgttg tgcaccacta tctagctcca gaaactttta 5940atcttcccaa
acagaaactt gtacctatta accaatacct tctccttcct cacttctcct 6000agaaaccaga
attatacttt ctgtctctac aaatctgact attctggata cctcagaatc 6060acagtatgtg
tcgttctacg actggcttgt ttcacttagc atcatgtctt caagggtcat 6120ccacgttata
gcatgtgtca gatttccttt tcttttcttt tctttttttt tttttttgag 6180acacagtctc
gctctgtcac ccaggctgga gggcagtagc acaatctcag ttcactgcag 6240cctctgcctt
ccaggttcaa gcaattctcg tgcctcagcc tcccaagtag ctggaatgac 6300aggcatgcac
caccacacct ggctaatttt tgtattttta gtagagacgg ggttttacca 6360tattggccag
gctggtcttg cacttccggc ctcaagtgat ctgcccgtct cggcctccca 6420aagtgctggg
attacaggcg tgagccacta tgcctggccc ccgattgtca ttatttaagg 6480ctaagtgata
ttttgttgtc tgtatatacc acaatttgtt tattcattca tctgtcaatg 6540gacatttggg
ttgtttccac cccctggtta ttgtggataa tactactagg aacacgagca 6600tacaaatatc
tgctccagtc cctgctttta tcttttggat atatgcccag aggtggaatt 6660gctgggtcat
aaggtaattc tagattaaat tttttgaggg actgccgtat tgttctccac 6720catagctgca
ccattttacc tttccagcag cagcgtacaa gcggtccagc ttctccacat 6780cttcacccac
acttgctatt tttggctttt attttatttt ttaaaataac attctaatgg 6840gtgttaagtg
gtcagaaatg gttcttttag gagtagagat agaggccagg gggatggctc 6900acacctgtaa
tcccagcact ttgggaggcc taggtgggcg gatcacttgg ggtcaggagt 6960ttgagatcag
cctggccaac atggtgaaac tccatctcta ttaaaaatac aaaaattcgc 7020tgggtgtggt
ggtgtgcact cccagctact tgggaggctg agggaagaga atcgcttgaa 7080cccgggaggc
ggtagttgca gtgagccgag atcacaccac tgtatggcct ggtgacagag 7140caaggctctg
tctcaaaaaa aaaaaaaaaa aaaaaagagt agagatagaa aagcattgaa 7200aacacagcct
cagctcagct cagtctgcca tggtgggaag ccattaattc ttcactcttg 7260aaaccttttc
gtccttggtg tggcagaggc tgcaagtctc ctctgcaact ttattcttcc 7320cttctttctc
agttataaaa tccctgattt tagaaatatc tttattgaga tataattcac 7380ataccataac
attcactaca attgaatggt ttttagtata ttcacagatt tgtacaacta 7440tcaccacaaa
ctaagtttag aacttttttc atcatcccac aaagaaaccc cacacccatt 7500agcagttatt
cactatttct ccccaatcaa cctcccctcc cctcaatagc cctaggcagc 7560caccagtcta
ctttctgtct ctacctattt gtcttttctg gacattttat acaaatgaga 7620ttttacaaca
tgtagtcttt tgtgactggc ttttttcccc tagcataatg ttttccaggt 7680tcatctgtgg
tgtagcaggt atcagtactt caaccctttt tattgccaaa taatattcca 7740ctatatggat
aggtaacatt ttgtttatcc attcatcaat tgatggacat ttgggttgtt 7800tccattttct
tgactgttat gaataatgtt gccatgaaca ttaatgcaca agtttttgtg 7860cagatgtgta
ttttcatgtg tcttggtttt atacctagga atagaattgc tgagtcatag 7920gagaactcct
ccatgtttaa ccattaatga actgccgaac tgttttccaa agaaattgca 7980ccattgtaca
atcccaccag caatgtatga gggtagaatc cctgattttt aactgatcat 8040tgaactcagg
cccattcaaa acaaagatga catttcctaa ccttccttac aagtagttct 8100gaccagtgag
atgggagaag aagttaggtt ttgtccttaa aagaaaggag agtggctggg 8160tgcagtggct
cacgcctgta atcccagcac tttgggaggc cgaggtgggc ggatcacctg 8220aggccgggag
ttcaagacta gcctgaccaa catggagaaa cctcgtctct actaaaaata 8280caaaattagc
tgggcgtcgt ggcgcatgcc tgtaatccca gctactcagg aggctgaggc 8340aggagaatcg
cttgaacctg ggaggtggag gttgtgatga gccgagattg tgccatcgca 8400ctctagcctg
ggcaagaaga gcgaaactcc atctcaaaaa aaaaaagaaa gaaaggagag 8460tacattctac
actctcctct cctccaccct gccccctttc cagtggctgg atgtggacat 8520ggtggtaagc
tatcttagat catgtggaca agggaaacac atagggatat tagaacctcc 8580agacagaagg
aacttaggac cctggacagc tttgtggagc agtgctccca taccagcgtg 8640aagttttgta
tgggagaaaa catacatttc cagcttttgt aagccactgt tattttgggt 8700ctctctcaga
gcagccaaat atataattta actaatatat tttctttctg tgattcttct 8760ttattttgat
tatacttcta cttctctgcc cctcttttag gtgggaggtg ctgctccaag 8820cactaactca
gaatatagac cctctccctc ttgtaatagt gccagcttgg agttctttgc 8880ttccactgta
ggggaaggaa ggaaaaaata tggagaactc acatccactc ttcattgtcc 8940tcaaacagaa
gtaacccatt ttgttctgct cacagcccat tggccagaac taactgtatg 9000gccccaatct
aattgcaaag gagtctggga agtacagcac agcacatgga tctttggaaa 9060gcgttaattt
tctctgccaa aggcttcttt tgttgttgtt gttgtttgaa atggagtccc 9120gctccgtcac
ccgggctgga gtgcagtggc cctatctcag ctcactgcaa cctccacctc 9180ccaggttcaa
gcactcctcc agccttggcc tcccaagtag ctaggattac aggcgtgtgc 9240catcatacct
ggctattttt tttgtatttt tagtagagac agggttttac cgtgttggcc 9300aggctggtct
caaactcttg gcttcaagtg atccgcctgc ttcggtctcc caaagtgttg 9360ggattacagg
cgtgagccac tgtacccggc caatactggt gttttctgac ctcagcgttt 9420ttcttttctc
ctgccatgta ctctccctag agatttcatc tactcccaag tcttccactg 9480ctcctatctg
ctgatgactc ccaaaactca gtctccagcc gagacttctc tcctgggctt 9540gagacatatg
tatccaactg ccagaacatc tccagtggac agcctttggg cacaaggcca 9600cactagcttg
tgggtacaag taatcaccca aagtcaattt cagtggctct ccactcccac 9660attttttcaa
cccctggaaa tgttcccttc ccaaatactc tgagtctctc ttctcttttg 9720atgactgtgg
ttttgtgact ggatggtagc tcctgttgct ttttttcctt tcaaatgaat 9780tttctcttag
gaggcttctt agccattaag caaatagacc tcaactgggc ttgccctatg 9840cctatctgaa
acccagctta ggttcgagtt aggactcctg ttaatctgag ctctcacttc 9900ctgtcccaac
ctgcttattt tttttggtga aagaaaatat catcccccta gttgctcaga 9960aacctgggaa
tcattgggat tttttcctct ccttcacctt cctcatccaa tcagtcacca 10020agtgctatca
actctgctgc cttagtagcc ctcaatatat acttacctat caaccatcac 10080tgctatgcca
tacttcaggc cttcatttct cacttggatt attaaaatat ccctaaatag 10140ttcctctgcc
ttctctctgg ccaccctcct gagtgatctc tccatcatgt acctttcagt 10200gactgcttgc
acaagcccct ttgtgacttg gtcatagtct gctctcttga accaccagag 10260ccaagcacct
gggttctgat tctggttgca actcttactg cgtgatgatg gacaggccac 10320ttgatctcct
caaacctcag ttcctaaatc aaatgaatga ttgaattcag tcacttaact 10380ttgtatgtag
taggtaggca ctgtgcaaaa catactagtg gatatagaga tgaataagaa 10440aaagcccctg
cactcaaaga gctctcggat tcatcaacaa attattgtgc agttagatag 10500taagtgctat
aatccaggaa tatacagtgt tgtgtgaata atgtggaatc agtttatctc 10560cagagcagaa
aaaggtgaag gccgaagaag gcattcagag tgatactgga gctgtgtagc 10620aggggctact
actgttccct caaatccttt cttctcttct tcctgagtaa tagagtcctt 10680tttcagctag
gcatacagcc atccaaaata aaaactatat ttcccagcct ccttttcagc 10740taagtgtagc
catgtgacta agttgtggcc aatgggatgt cagtacaagt ggtaatggca 10800atatctggga
tgtgtcttta aaaggaagga acatgtcctt ctccttttcc tccttcctgt 10860tccctgggag
gtgaacttgg tagctggagg tgaagcagct ggaacttgga tatgagcgtc 10920ttgttgatga
taatagtgca acaagataaa agcagcccga gctggcctac atttacatga 10980gaaggaaata
agactccatt ttgtttaagc tattctcttg catatatata tacacatata 11040tatcagctaa
gtgtagccat gtgactaact tgtggccaat gggatgtcag tatgagtggt 11100aagagcagta
tcttgtatat atatatgtgt atatatacac acacacatat atatacatat 11160atgtatgcaa
gaatataaaa tatacatgtg tgtgtgtata tatatacaca catatatatg 11220tcccttgcag
ccaagtctaa ttctaactaa tacaaactaa ctctaaaaaa tgaatatata 11280ttcaccaggg
gataggctat ttcaagcaga gggaagcctg tataaaggct cagggaatgc 11340tgtggtttta
tgtggcagca gatgagactg gaaatgagtc aggatgagcc acagtggagg 11400atgaattaaa
tgggcaggag tgtggtagaa agacctgttg gaggctatga atgcaatcaa 11460ggtgacagac
aactggtgca atgatggtag tggaaatgga ggagagggga ttgattcaag 11520atgcatttag
gaccaagaat cgggagcttg tgaacgtgtg tatgagtact gtagacggag 11580tgggtgtgtc
atcagagaag atctgagcat ttgggcttgc tctcctcaga ggccctgcga 11640gtggagttca
gcttttcctc atggggcaaa tctyactttc gctccagttc ctggggctca 11700gagtccctgg
cccagatgcc tcttgccatc tcatcttcac cctgcctggc ttcccttgct 11760tgttccagga
ttgtttcata aagagggatg tggttggtct ttaaccctat gaatgctggc 11820tgaggatgcc
tgcggaacct gtagtgaagc tttcaggggc tgctcgggtt ctggctggta 11880ggtgaacact
gtccatcttg ccggctggga cacagtgact ctgggtagtt gtgtaagaga 11940ggggcccttg
gcagacaaac aggttcttct ctgttggtgg gccagccagc aggtcagtgg 12000gaaggttaaa
ggtcatgggg tttgggagaa actgggtgag gagttcagcc ccatcccccg 12060taaagctcct
gggaagcact tctctactgg ggcagcccct gataccaggg cactcattaa 12120ccctctgggt
gccagggaaa gggcaggagg tgagtgctgg gaggcagctg aggtcaactt 12180cttttgaact
tccacgtggt atttactcag agcaattggt gccagaggct cagggccctg 12240gagtataaag
cagaatgtct gctctctgtg cccagacgtg agcaggtgag cagctggggc 12300agagggatgg
gggtcacagt cctaagggag ggcattgcag gtggcctcag gggagagcct 12360ggggtggccc
ctaagacgtc ctcttggaac attttggcag agttgcctct tcgccctcat 12420tatggctcag
tttttccacc atgaaatggg agggagggag acaggtgggc aggggagagg 12480tggtagaagt
ggcctagaga actgttcctg gggtctggga cctttgcgaa ggggttagag 12540caccacgctc
cctgctatgt gactgaggta gcaagagcac gccctcttcc catgtttgag 12600gaagacaccc
tagcctcctt gactcaccta ggtcagtcct cttgagcccc aacagctctg 12660tgctccccag
cccaaggaag gggtaacagg atttcgggca gttgcccctg cagaggcccc 12720ctgggcaagt
cccctgcgcc atgtcccttc gtctccttct tcccctaacc aggcctccct 12780ccacctgtct
tctcagagca grta atg gca agc atg gct gcc gtg ctc acc 12831Met Ala Ser
Met Ala Ala Val Leu Thr1 5tgg gct ctg gct ctt ctt tca g
gtgggtctcc gaccctgact tcaacgtggg 12883Trp Ala Leu Ala Leu Leu Ser10
15ggtgtgggtg gaggctggcc agagggccct gtccaccctg ggggaggaga
gcccaggccc 12943tgattaccta gtccctctcc acag cg ttt tsg gcc acc cag gca
cgg aaa 12993Ala Phe Xaa Ala Thr Gln Ala Arg Lys 20
25ggc ttc tgg gac tac ttc agc cag acc agc ggg gac aaa ggc agg
gtg 13041Gly Phe Trp Asp Tyr Phe Ser Gln Thr Ser Gly Asp Lys Gly Arg
Val 30 35 40gag cag atc
cat cag cag aag atg gct cgc gag ccc gc gtgagtgccc 13089Glu Gln Ile
His Gln Gln Lys Met Ala Arg Glu Pro Ala 45
50aggggaaggg gtgtaggcga agggaggaga cagctgggcc atgccatgat gacctgcctc
13149tgctgcctca acctctgtgg ccgctgctgg gacagaggaa aggagcggtg ctagctctgt
13209ctgcagatcc cggccatcct gggctcttta gcgccctctg cctgcagccc ccgccttgac
13269aactccgtag ctgttgcccc cttgctcact gaggcgcggg acctgggatc aatcgggagg
13329acgcccgctg cagtccccag aatcaaagga tgatgtggcg catctatgtt tctttggaga
13389gtgttgtagg tctggatttg tatgggcaat gtgtttgtgc ttcgtgcgtg agttgttact
13449ggccagggct aggacaagag ccctcgaccc tggggccaac gccctgcgtc cttggttccc
13509ccagaggatc agtgcgcgat gacttgggga caaaggagat gatggrggct agcagtctga
13569cggcctggat atctgtcccc ttctccag g acc ctg aaa gac agc ctt gag caa
13622Thr Leu Lys Asp Ser Leu Glu Gln55 60gac ctc aac aat
atg aac aag ttc ctg gaa aag ctg agg cct ctg agt 13670Asp Leu Asn Asn
Met Asn Lys Phe Leu Glu Lys Leu Arg Pro Leu Ser 65
70 75ggg agc gag gct cct cgg ctc cca cag gac ccg gtg
ggc atg cgg cgg 13718Gly Ser Glu Ala Pro Arg Leu Pro Gln Asp Pro Val
Gly Met Arg Arg 80 85 90cag ctg cag
gag gag ttg gag gag gtg aag gct cgc ctc cag ccc tac 13766Gln Leu Gln
Glu Glu Leu Glu Glu Val Lys Ala Arg Leu Gln Pro Tyr95
100 105 110atg gca gag gcg cac gag ctg
gtg ggc tgg aat ttg gag ggc ttg cgg 13814Met Ala Glu Ala His Glu Leu
Val Gly Trp Asn Leu Glu Gly Leu Arg 115
120 125cag caa ctg aag ccc tac acg atg gat ctg atg gag
cag gtg gcc ctg 13862Gln Gln Leu Lys Pro Tyr Thr Met Asp Leu Met Glu
Gln Val Ala Leu 130 135 140cgc
gtg cag gag ctg cag gag cag ttg cgc gtg gtg ggg gaa gac acc 13910Arg
Val Gln Glu Leu Gln Glu Gln Leu Arg Val Val Gly Glu Asp Thr 145
150 155aag gcc cag ttg ctg ggg ggc gtg gac
gag gct tgg gct ttg ctg cag 13958Lys Ala Gln Leu Leu Gly Gly Val Asp
Glu Ala Trp Ala Leu Leu Gln 160 165
170gga ctg cag agc cgc gtg gtg cac cac acc ggc cgc ttc aaa gag ctc
14006Gly Leu Gln Ser Arg Val Val His His Thr Gly Arg Phe Lys Glu Leu175
180 185 190ttc cac cca tac
gcc gag agc ctg gtg agc ggc atc ggg cgc cac gtg 14054Phe His Pro Tyr
Ala Glu Ser Leu Val Ser Gly Ile Gly Arg His Val 195
200 205cag gag ctg cac cgc agt gtg gct ccg cac
gcc ccc gcc agc ccc gcg 14102Gln Glu Leu His Arg Ser Val Ala Pro His
Ala Pro Ala Ser Pro Ala 210 215
220cgc ctc agt cgc tgc gtg cag gtg ctc tcc cgg aag ctc acg ctc aag
14150Arg Leu Ser Arg Cys Val Gln Val Leu Ser Arg Lys Leu Thr Leu Lys
225 230 235gcc aag gcc ctg cac gca cgc
atc cag cag aac ctg gac cag ctg cgc 14198Ala Lys Ala Leu His Ala Arg
Ile Gln Gln Asn Leu Asp Gln Leu Arg 240 245
250gaa gag ctc agc aga gcc ttt gca ggc act ggg act gag gaa ggg gcc
14246Glu Glu Leu Ser Arg Ala Phe Ala Gly Thr Gly Thr Glu Glu Gly Ala255
260 265 270ggc ccg gac ccc
cag atg ctc tcc gag gag gtg cgc cag cga ctt cag 14294Gly Pro Asp Pro
Gln Met Leu Ser Glu Glu Val Arg Gln Arg Leu Gln 275
280 285gct ttc cgc cag gac acc tac ctg cag ata
gct gcc ttc act cgc gcc 14342Ala Phe Arg Gln Asp Thr Tyr Leu Gln Ile
Ala Ala Phe Thr Arg Ala 290 295
300atc gac cag gag act gag gag gtc cag cag cag ctg gcg cca cct cca
14390Ile Asp Gln Glu Thr Glu Glu Val Gln Gln Gln Leu Ala Pro Pro Pro
305 310 315cca ggc cac agt gcc ttc gcc
cca gag ttt caa caa aca gac agt ggc 14438Pro Gly His Ser Ala Phe Ala
Pro Glu Phe Gln Gln Thr Asp Ser Gly 320 325
330aag gtt ctg agc aag ctg cag gcc cgt ctg gat gac ctg tgg gaa gac
14486Lys Val Leu Ser Lys Leu Gln Ala Arg Leu Asp Asp Leu Trp Glu Asp335
340 345 350atc act cac agc
ctt cat gac cag ggc cac agc cat ctg ggg gac ccc 14534Ile Thr His Ser
Leu His Asp Gln Gly His Ser His Leu Gly Asp Pro 355
360 365tga ggatctacct gcccaggccc attcccagct
ccttgtctgg ggagccttgg 14587ctctgagcct ctagcatggt tcagtccttg
aaagtggcct gttgggtgga gggtggaagg 14647tcctgtgcag gacagggagg ccaccaaagg
ggctgctgtc tcctgcayat ccagcctcct 14707gcgactcccc aatctggatg cattacattc
accaggcttt gcaaacccag cctcccagtg 14767ctcatttggg aatgctcatg agttactcca
ttcaagggtg agggagtagg gagggagagg 14827caccatgcat gtgggtgatt atctgcaagc
ctgtttgccg tgatgctgga agcctgtgcc 14887actacatcct ggagtttggc tctagtcact
tctggctgcc tggtggccac tgctacagct 14947ggtccacaga gaggagcact tgtctcccca
gggctgccat ggcagctatc aggggaatag 15007aagggagaaa gagaatatca tggggagaac
atgtgatggt gtgtgaatat ccctgctggc 15067tctgatgctg gtgggtacga aaggtgtggg
ctgtgatagg agagggcaga gcccatgttt 15127cctgacatag ctctacacct aaataaggga
ctgaaccctc ccaactgtgg gagctcctta 15187aaccctctgg ggagcatact gtgtgctctc
cccatctcca gcccctccct ctgggttccc 15247aagttgaagc ctagacttct ggctcaaatg
aaatagatgt ttatgataga agtttgcctg 15307gcgtgactct catttggacc atgtctgaaa
gcagtggcct caccactatc cccaaagcac 15367acccatcacc cactccattc ccttgctgct
ctttctcatc cacccactcc cagtccaggt 15427ctgtcaaagg gggtctggct gggctctgct
tcagggatcc tggctagaca acggctgtct 15487gtcacacctg gcaggagggc ctgggttacg
ggcccttcct ctgcacctgc actgttcact 15547agcctgctcc cccacaggac actgtgcatg
gaatgcaggc tgtgtctgga agagctgtgg 15607ccctggtgga cctaagattc ctgaggtggg
ctgcctcctt tgttcctgct gttctagagt 15667ttgaatggcc tctttttatg ccggactctc
ttctggggac tcccctcact caggggcacc 15727aatgctccct atagatcccc tgggaactga
aactggggtg tggtggagga cgtggaaagg 15787gtaaacacag ctccttgtct ttggacttcc
ctgtccggcc ccctttcctc ccagctcagc 15847ctactgtccc cgggttctca gcacctgcct
gctccccaac cccatagcac agaccccaca 15907catatgtagg ctcatcatgc ctgcaggctg
gtcttccctg acaccgtgga ttttgacaat 15967gttggcaaca gaactgggtt gtggacccag
cac 16000416000DNAhomo sapiens 4ctcaagtaat
ccttctgcct cagcctcctg agtagctagg accacaggtg ccaccatacc 60tggctaattt
ttgtattctt tgcagagaca gggtctcgct acattgccca ggctggtatc 120gaactcctgg
gctcaagcga tcctcctgcc ttgccttctc aaagtgttgg gattacaggc 180atgagccact
gtgcccagcc tcaaaattta atgtataaag ttttccttaa tttttcttag 240cacaaaaacc
ctggccccca acaataccta gttttctcca ggccggagtc ccactctttt 300acccttttca
gagagaataa gcatctggtt ttctgctgct ttgggggtac ccagccaagt 360agagttgaag
agaacagctg cttctcaaac agactctcga ccaactgcca tatttctagt 420cccactgcca
cccactcttc cagaagaatg ttgacactaa tgtcagagca tttggagagt 480ttagtagtga
aaatcagggg ccttcttggc tttctccact gctgcttcaa aattcatgtc 540aggtgtgcct
gtcaccaccg tttgaccatt tggaagcttt ccagcttccc aaatgttgtt 600atttttgtct
ccttttctat tttccctttg ggtttatgca ttttgtaaaa agtgcacttc 660aatgccacgt
tattgagatt tcagagaaca gcagaggcta atgcatgcaa ttaatccacc 720gtccgttact
agaagtcaat cggatgctct ttagtctctc ttccccatat actagtttaa 780aagttatcca
ttctttctat tcgttttatg ggttatcctt aaaattttaa tattcttgtc 840tgacctaaca
aagtctatag ataatcaata tccctatctt tctcccgaat aatgcaaagg 900ctgctgaatg
ctttcacttt gatctctcct ttcccatttc caggttgctt cggtctgata 960ttttagttcc
tcattacttt taacacctcc tccaaagtag tcccttcatc aatagatgtt 1020tttgagccct
ccctaccatg tgataagcac tggtctaggc actgggagta cagtaggaaa 1080tgagataaac
ttggccaggt gtagggtggc ttacacctgt aatcccaaca cttttgaggc 1140cgaggcgggc
agctcgcttg agcccatgag ttcgagacca gcctgggaaa catagcgaga 1200cccccgtccc
tacaaaaaaa tataaaaatt agctgggcat ggtggtgtat gcctgtggtc 1260ctagctactc
agaagactga ggtgggagga tcatctgagc ccagggtggt cgaggctgca 1320gtgattacac
cactgcactc catcctgggc aacggtgaga ccctgtctca aaaaacaaac 1380aaacaaacaa
gcaaacaaaa cccccacaaa ctaaactatg tgtaaataca tttttgttag 1440gtagaactat
atgaaattgc cactatttga ccaattttta gtgaaaacta gtctcataag 1500tgtgtgtgtg
tgtattttca ctaatgtttt ttggatttac ctaaacgttt actaatttca 1560ttgctcccca
tgtctccttc tatcctattc cttttttctg ggttctgttt ccttttcaga 1620tttttagtag
ttcttttcag tgaggatctg tgagtggtaa actctctttc tctgaaatta 1680acttcttcct
ctcaaataat agttcacctg agtataagtc ttggttggcc attaatttcc 1740tttcagtctt
tagaaggtac attgatgata aatcagttgc cggtttaatc atgcttcgtg 1800tgtagatcat
tagtctttct ctttggttga ttttaagata tccattgcct tcagtgttct 1860gcagattcct
gtgatgtgtc ctcatttggt tgtgtgttaa tttttcctac caagactcag 1920gatgcttcct
gtacctgagg attccggtca catcttgctt caatgtttga aatttctcag 1980ccatcatctt
ttgaatattg cctcttccac agtccctgtg ttctcttcgt ggaaatccta 2040caggcatata
ttggacctcc cattctgtcc tccatgtctc ttaccgtcta ttcataccct 2100cctttttata
tttaattttt ttgagacaga gttttgctct gtggcccagg acggagtgca 2160attgcatgat
cttggctcac ggcaaactct gcctcccagg ttcaagctat tctcctgcct 2220cagtctccca
agtagctggg attacaggca tgcaccacca cgcccggcta atttttgtat 2280ttttagtaga
gacggggttt caccatattg gccaggctgg tctgaaactc ctgacctcag 2340gtgatccacc
cacctcggcc tcccaaagtg ctgggattat aggcatgagc caccatgcct 2400ggccaatatc
acccgcctcg gcctcccaaa gtgctgggat tacaggcatg agccaccgtg 2460cctggtcaat
atcctccttt ttatttctgt gattctttct gtgtgatttt ctcagatcta 2520ccttctagct
tactaattct ctctccaact gtagctaaat gtgttttata ttataatgac 2580tatatttttt
tcacttatag atgttctatt taattctctt tctttttgac aaatagaact 2640tatttcaaaa
caaacaaaag gccaggcatg gtggttcatg cctgtaatcc cagtgctttg 2700ggaggctgag
gcaggaggat tgcttgagcc caggagttca aggccagcct gggcaacata 2760gtgagatcct
ttctctacca aaaaaataaa aaatcagctg ggtgttgtgg gacactcctg 2820tagtcccaga
aactacagat tcttgggagg cagaggctgg aggattgctt gaggcagagg 2880ctggaggatt
gcttgagcct gggaggttga ggctgcagtg aactgtgatc atgccactgc 2940actctagcct
gggtgacaaa gtgagatcct gtctcaaaaa caaataaaca aacaagcaaa 3000gaaacaaaaa
aatgcttaca caggttacta ctttcttgct gggatagttt taacactgcg 3060ttaagcataa
acacctttct ttctgaaatg tatttgagat gtatattgat ttttaaaaaa 3120cccacacctc
cattaaggtc tggtgatagc agtagaaaca atgtagagtg gctccacaat 3180catatagatg
tttttggtgc gttctgagat ggagtccagg aacaccaagt aaagactgct 3240acctcacagt
ttacatctga gttcttagaa gacaagactg aaggagaaca atttgtaaca 3300agatttactt
ggcccgggtg tggtggctca cacctgtaat cccagtactt tgggagcttt 3360gggagtccga
ggtgggtgga tcacctgagg tcaggagttc aagaccagcc tggccaacat 3420ggaataaccc
ccatctctac taaaaataca aaaattagcc aggcacggtg gcacacgcct 3480gtaatcccag
ctactcagga ggctgaggca ggagaatcgc ttgaacccaa gtgactgggt 3540tgccgagagc
cgagatcacg ccactgtact ccagccaccc tgggtgacag agtgagactc 3600tgccaaaaaa
aaaaaaaaaa aaaaaaaaat acttactgtt cagaaggaga agtcataatg 3660ttgctttaaa
gaacaggtca caaaagaaag actctagaag atcttctcac ttggtgcata 3720tcaagtgtct
atttgagacc catacacttg cttaatccat gtgtttaagg caaaagtgct 3780gctgctgagc
agtaaggaat aaggtacctg ctaaccttta ccaatctaca ttttaaaatc 3840cttcttacta
cacatccaga atgagtcagc aattcttgtg tattaaaaaa caaaaacaca 3900aaacaaagta
gaggggcaac tctcttaaaa atgcagctat ccgcaaacac tgtgatacaa 3960aacgacagtc
aaggaaaggg cagcacaaac aagttcacct ggaaggaatc tgttcaaagt 4020ctctggattt
aagaacaagt tccctaaaag ctcttactta cagaagaaat cggataataa 4080atgtagctgg
aatgatggaa ttctttaagt tttcattttg ttttgggcaa ctctgtggcc 4140caggctggag
tgcagtggct tgatcacggc tcactgcagc ctcaacctcc caggctctgg 4200tgatcctccc
acctcagcct cctgagtggc tgggactaca agcatgtgtg ccaccatgct 4260aggctaattt
ttgtatttta tttttagttt tttttttttt tttttttttt ttgtagagac 4320aggttttgcc
atgttgccaa ggctggtctc aaattcctgg gttcaagtga tcctcccatc 4380tcagccttcc
aaagagctgg gattacaggc atgagctact gcacctggcc tagaattttt 4440taaaaatcac
tatctggcaa ctctcaggat aatattcgat tcaggcaagg atcatcaatg 4500aatgctaaaa
ccattgggtg aaaaattgtt gcagaatggg atgctcacat ggcttcaaag 4560tattgctcca
caaattactt atcaataacg taaaaaacca aactttacta gccatggaga 4620aatctggttg
ttatcacttt aatggagtga tcaaacttaa catcactaaa tagagtgcaa 4680cctccagcta
ggatacagta agaagggcca gatatcacct agtatttttg ccaaaaatgt 4740ttaaccttaa
tctaatcatg agaaagtaat cactcaaatc cagaatgtgg gacattttac 4800aagatgtcct
ccttgcactc ttccaaaaaa aaatcaatgt catgaaaaca aacaaatggt 4860ggggttgggg
agaacggttc taaatttaaa aactaaagtg ggataacaac cagatgagat 4920gtgttagagc
ttgaatttac agagagagaa aaacaactat gaaagcattt tggggaaaat 4980ctgaatatgt
aggatatgtt agatgatatt aaggaattgt gttaattttc aaaggtatga 5040taatgttttt
ttcttttgta aaagagtcct tatttttcac aatgtatgtt gaagtattca 5100gagtgaagtg
tcatgttggc tataattatt tcaaatggtt ccacacacaa agcacatacc 5160acatacacat
atacatatac ctccaaccaa ctcaaaacat gttcaacact gaaactataa 5220gatgccacca
aacagggaag catgagtgtg tgttgcatct acccattgta tcaatccagg 5280ttcagtcaga
aaaacaaaag ccattccacg tatttcaagc atgaaaggct ttaaaacaaa 5340aaattaaagg
tttatccaac tcttggaagg gctggaggag tgaccacctt ggtttgcagt 5400tcagaaggag
tgactctcaa acgctcatta gtaagtggct acaaatggga agctcgcctt 5460attatgcctg
caatatcaat gcatgtgatt cctgggaagg tcacccagaa gctgctttaa 5520actccaagcc
tgtccatgct tctgtctgca accggcattg aaacataatg gcctctcctc 5580ttccgtctca
cgctggctga ctctaaccta ggctcatata gagaagggat tctagaaaat 5640gtattaatag
ttccaagtgt cccctctgca tctcataaaa gaccttagaa agggcactga 5700taatgctatt
tgcaaaaaga caatccagcg cagttgtatt ttacagcaca ggctctttaa 5760gtttgggtta
tcagcaaaaa accattagag tatgagaaat tcctttttaa attgtggcaa 5820aatatacata
acataaaaat taccattgta gctattgtac attgtagcta agtatatagc 5880ccagtagcac
taaatacatt tacactgttg tgcaccacta tctagctcca gaaactttta 5940atcttcccaa
acagaaactt gtacctatta accaatacct tctccttcct cacttctcct 6000agaaaccaga
attatacttt ctgtctctac aaatctgact attctggata cctcagaatc 6060acagtatgtg
tcgttctacg actggcttgt ttcacttagc atcatgtctt caagggtcat 6120ccacgttata
gcatgtgtca gatttccttt tcttttcttt tctttttttt tttttttgag 6180acacagtctc
gctctgtcac ccaggctgga gggcagtagc acaatctcag ttcactgcag 6240cctctgcctt
ccaggttcaa gcaattctcg tgcctcagcc tcccaagtag ctggaatgac 6300aggcatgcac
caccacacct ggctaatttt tgtattttta gtagagacgg ggttttacca 6360tattggccag
gctggtcttg cacttccggc ctcaagtgat ctgcccgtct cggcctccca 6420aagtgctggg
attacaggcg tgagccacta tgcctggccc ccgattgtca ttatttaagg 6480ctaagtgata
ttttgttgtc tgtatatacc acaatttgtt tattcattca tctgtcaatg 6540gacatttggg
ttgtttccac cccctggtta ttgtggataa tactactagg aacacgagca 6600tacaaatatc
tgctccagtc cctgctttta tcttttggat atatgcccag aggtggaatt 6660gctgggtcat
aaggtaattc tagattaaat tttttgaggg actgccgtat tgttctccac 6720catagctgca
ccattttacc tttccagcag cagcgtacaa gcggtccagc ttctccacat 6780cttcacccac
acttgctatt tttggctttt attttatttt ttaaaataac attctaatgg 6840gtgttaagtg
gtcagaaatg gttcttttag gagtagagat agaggccagg gggatggctc 6900acacctgtaa
tcccagcact ttgggaggcc taggtgggcg gatcacttgg ggtcaggagt 6960ttgagatcag
cctggccaac atggtgaaac tccatctcta ttaaaaatac aaaaattcgc 7020tgggtgtggt
ggtgtgcact cccagctact tgggaggctg agggaagaga atcgcttgaa 7080cccgggaggc
ggtagttgca gtgagccgag atcacaccac tgtatggcct ggtgacagag 7140caaggctctg
tctcaaaaaa aaaaaaaaaa aaaaaagagt agagatagaa aagcattgaa 7200aacacagcct
cagctcagct cagtctgcca tggtgggaag ccattaattc ttcactcttg 7260aaaccttttc
gtccttggtg tggcagaggc tgcaagtctc ctctgcaact ttattcttcc 7320cttctttctc
agttataaaa tccctgattt tagaaatatc tttattgaga tataattcac 7380ataccataac
attcactaca attgaatggt ttttagtata ttcacagatt tgtacaacta 7440tcaccacaaa
ctaagtttag aacttttttc atcatcccac aaagaaaccc cacacccatt 7500agcagttatt
cactatttct ccccaatcaa cctcccctcc cctcaatagc cctaggcagc 7560caccagtcta
ctttctgtct ctacctattt gtcttttctg gacattttat acaaatgaga 7620ttttacaaca
tgtagtcttt tgtgactggc ttttttcccc tagcataatg ttttccaggt 7680tcatctgtgg
tgtagcaggt atcagtactt caaccctttt tattgccaaa taatattcca 7740ctatatggat
aggtaacatt ttgtttatcc attcatcaat tgatggacat ttgggttgtt 7800tccattttct
tgactgttat gaataatgtt gccatgaaca ttaatgcaca agtttttgtg 7860cagatgtgta
ttttcatgtg tcttggtttt atacctagga atagaattgc tgagtcatag 7920gagaactcct
ccatgtttaa ccattaatga actgccgaac tgttttccaa agaaattgca 7980ccattgtaca
atcccaccag caatgtatga gggtagaatc cctgattttt aactgatcat 8040tgaactcagg
cccattcaaa acaaagatga catttcctaa ccttccttac aagtagttct 8100gaccagtgag
atgggagaag aagttaggtt ttgtccttaa aagaaaggag agtggctggg 8160tgcagtggct
cacgcctgta atcccagcac tttgggaggc cgaggtgggc ggatcacctg 8220aggccgggag
ttcaagacta gcctgaccaa catggagaaa cctcgtctct actaaaaata 8280caaaattagc
tgggcgtcgt ggcgcatgcc tgtaatccca gctactcagg aggctgaggc 8340aggagaatcg
cttgaacctg ggaggtggag gttgtgatga gccgagattg tgccatcgca 8400ctctagcctg
ggcaagaaga gcgaaactcc atctcaaaaa aaaaaagaaa gaaaggagag 8460tacattctac
actctcctct cctccaccct gccccctttc cagtggctgg atgtggacat 8520ggtggtaagc
tatcttagat catgtggaca agggaaacac atagggatat tagaacctcc 8580agacagaagg
aacttaggac cctggacagc tttgtggagc agtgctccca taccagcgtg 8640aagttttgta
tgggagaaaa catacatttc cagcttttgt aagccactgt tattttgggt 8700ctctctcaga
gcagccaaat atataattta actaatatat tttctttctg tgattcttct 8760ttattttgat
tatacttcta cttctctgcc cctcttttag gtgggaggtg ctgctccaag 8820cactaactca
gaatatagac cctctccctc ttgtaatagt gccagcttgg agttctttgc 8880ttccactgta
ggggaaggaa ggaaaaaata tggagaactc acatccactc ttcattgtcc 8940tcaaacagaa
gtaacccatt ttgttctgct cacagcccat tggccagaac taactgtatg 9000gccccaatct
aattgcaaag gagtctggga agtacagcac agcacatgga tctttggaaa 9060gcgttaattt
tctctgccaa aggcttcttt tgttgttgtt gttgtttgaa atggagtccc 9120gctccgtcac
ccgggctgga gtgcagtggc cctatctcag ctcactgcaa cctccacctc 9180ccaggttcaa
gcactcctcc agccttggcc tcccaagtag ctaggattac aggcgtgtgc 9240catcatacct
ggctattttt tttgtatttt tagtagagac agggttttac cgtgttggcc 9300aggctggtct
caaactcttg gcttcaagtg atccgcctgc ttcggtctcc caaagtgttg 9360ggattacagg
cgtgagccac tgtacccggc caatactggt gttttctgac ctcagcgttt 9420ttcttttctc
ctgccatgta ctctccctag agatttcatc tactcccaag tcttccactg 9480ctcctatctg
ctgatgactc ccaaaactca gtctccagcc gagacttctc tcctgggctt 9540gagacatatg
tatccaactg ccagaacatc tccagtggac agcctttggg cacaaggcca 9600cactagcttg
tgggtacaag taatcaccca aagtcaattt cagtggctct ccactcccac 9660attttttcaa
cccctggaaa tgttcccttc ccaaatactc tgagtctctc ttctcttttg 9720atgactgtgg
ttttgtgact ggatggtagc tcctgttgct ttttttcctt tcaaatgaat 9780tttctcttag
gaggcttctt agccattaag caaatagacc tcaactgggc ttgccctatg 9840cctatctgaa
acccagctta ggttcgagtt aggactcctg ttaatctgag ctctcacttc 9900ctgtcccaac
ctgcttattt tttttggtga aagaaaatat catcccccta gttgctcaga 9960aacctgggaa
tcattgggat tttttcctct ccttcacctt cctcatccaa tcagtcacca 10020agtgctatca
actctgctgc cttagtagcc ctcaatatat acttacctat caaccatcac 10080tgctatgcca
tacttcaggc cttcatttct cacttggatt attaaaatat ccctaaatag 10140ttcctctgcc
ttctctctgg ccaccctcct gagtgatctc tccatcatgt acctttcagt 10200gactgcttgc
acaagcccct ttgtgacttg gtcatagtct gctctcttga accaccagag 10260ccaagcacct
gggttctgat tctggttgca actcttactg cgtgatgatg gacaggccac 10320ttgatctcct
caaacctcag ttcctaaatc aaatgaatga ttgaattcag tcacttaact 10380ttgtatgtag
taggtaggca ctgtgcaaaa catactagtg gatatagaga tgaataagaa 10440aaagcccctg
cactcaaaga gctctcggat tcatcaacaa attattgtgc agttagatag 10500taagtgctat
aatccaggaa tatacagtgt tgtgtgaata atgtggaatc agtttatctc 10560cagagcagaa
aaaggtgaag gccgaagaag gcattcagag tgatactgga gctgtgtagc 10620aggggctact
actgttccct caaatccttt cttctcttct tcctgagtaa tagagtcctt 10680tttcagctag
gcatacagcc atccaaaata aaaactatat ttcccagcct ccttttcagc 10740taagtgtagc
catgtgacta agttgtggcc aatgggatgt cagtacaagt ggtaatggca 10800atatctggga
tgtgtcttta aaaggaagga acatgtcctt ctccttttcc tccttcctgt 10860tccctgggag
gtgaacttgg tagctggagg tgaagcagct ggaacttgga tatgagcgtc 10920ttgttgatga
taatagtgca acaagataaa agcagcccga gctggcctac atttacatga 10980gaaggaaata
agactccatt ttgtttaagc tattctcttg catatatata tacacatata 11040tatcagctaa
gtgtagccat gtgactaact tgtggccaat gggatgtcag tatgagtggt 11100aagagcagta
tcttgtatat atatatgtgt atatatacac acacacatat atatacatat 11160atgtatgcaa
gaatataaaa tatacatgtg tgtgtgtata tatatacaca catatatatg 11220tcccttgcag
ccaagtctaa ttctaactaa tacaaactaa ctctaaaaaa tgaatatata 11280ttcaccaggg
gataggctat ttcaagcaga gggaagcctg tataaaggct cagggaatgc 11340tgtggtttta
tgtggcagca gatgagactg gaaatgagtc aggatgagcc acagtggagg 11400atgaattaaa
tgggcaggag tgtggtagaa agacctgttg gaggctatga atgcaatcaa 11460ggtgacagac
aactggtgca atgatggtag tggaaatgga ggagagggga ttgattcaag 11520atgcatttag
gaccaagaat cgggagcttg tgaacgtgtg tatgagtact gtagacggag 11580tgggtgtgtc
atcagagaag atctgagcat ttgggcttgc tctcctcaga ggccctgcga 11640gtggagttca
gcttttcctc atggggcaaa tcttactttc gctccagttc ctggggctca 11700gagtccctgg
cccagatgcc tcttgccatc tcatcttcac cctgcctggc ttcccttgct 11760tgttccagga
ttgtttcata aagagggatg tggttggtct ttaaccctat gaatgctggc 11820tgaggatgcc
tgcggaacct gtagtgaagc tttcaggggc tgctcgggtt ctggctggta 11880ggtgaacact
gtccatcttg ccggctggga cacagtgact ctgggtagtt gtgtaagaga 11940ggggcccttg
gcagacaaac aggttcttct ctgttggtgg gccagccagc aggtcagtgg 12000gaaggttaaa
ggtcatgggg tttgggagaa actgggtgag gagttcagcc ccatcccccg 12060taaagctcct
gggaagcact tctctactgg ggcagcccct gataccaggg cactcattaa 12120ccctctgggt
gccagggaaa gggcaggagg tgagtgctgg gaggcagctg aggtcaactt 12180cttttgaact
tccacgtggt atttactcag agcaattggt gccagaggct cagggccctg 12240gagtataaag
cagaatgtct gctctctgtg cccagacgtg agcaggtgag cagctggggc 12300agagggatgg
gggtcacagt cctaagggag ggcattgcag gtggcctcag gggagagcct 12360ggggtggccc
ctaagacgtc ctcttggaac attttggcag agttgcctct tcgccctcat 12420tatggctcag
tttttccacc atgaaatggg agggagggag acaggtgggc aggggagagg 12480tggtagaagt
ggcctagaga actgttcctg gggtctggga cctttgcgaa ggggttagag 12540caccacgctc
cctgctatgt gactgaggta gcaagagcac gccctcttcc catgtttgag 12600gaagacaccc
tagcctcctt gactcaccta ggtcagtcct cttgagcccc aacagctctg 12660tgctccccag
cccaaggaag gggtaacagg atttcgggca gttgcccctg cagaggcccc 12720ctgggcaagt
cccctgcgcc atgtcccttc gtctccttct tcccctaacc aggcctccct 12780ccacctgtct
tctcagagca gataatggca agcatggctg ccgtgctcac ctgggctctg 12840gctcttcttt
caggtgggtc tccgaccctg acttcaacgt gggggtgtgg gtggaggctg 12900gccagagggc
cctgtccacc ctgggggagg agagcccagg ccctgattac ctagtccctc 12960tccacagcgt
tttcggccac ccaggcacgg aaaggcttct gggactactt cagccagacc 13020agcggggaca
aaggcagggt ggagcagatc catcagcaga agatggctcg cgagcccgcg 13080tgagtgccca
ggggaagggg tgtaggcgaa gggaggagac agctgggcca tgccatgatg 13140acctgcctct
gctgcctcaa cctctgtggc cgctgctggg acagaggaaa ggagcggtgc 13200tagctctgtc
tgcagatccc ggccatcctg ggctctttag cgccctctgc ctgcagcccc 13260cgccttgaca
actccgtagc tgttgccccc ttgctcactg aggcgcggga cctgggatca 13320atcgggagga
cgcccgctgc agtccccaga atcaaaggat gatgtggcgc atctatgttt 13380ctttggagag
tgttgtaggt ctggatttgt atgggcaatg tgtttgtgct tcgtgcgtga 13440gttgttactg
gccagggcta ggacaagagc cctcgaccct ggggccaacg ccctgcgtcc 13500ttggttcccc
cagaggatca gtgcgcgatg acttggggac aaaggagatg atgggggcta 13560gcagtctgac
ggcctggata tctgtcccct tctccaggac cctgaaagac agccttgagc 13620aagacctcaa
caatatgaac aagttcctgg aaaagctgag gcctctgagt gggagcgagg 13680ctcctcggct
cccacaggac ccggtgggca tgcggcggca gctgcaggag gagttggagg 13740aggtgaaggc
tcgcctccag ccctacatgg cagaggcgca cgagctggtg ggctggaatt 13800tggagggctt
gcggcagcaa ctgaagccct acacgatgga tctgatggag caggtggccc 13860tgcgcgtgca
ggagctgcag gagcagttgc gcgtggtggg ggaagacacc aaggcccagt 13920tgctgggggg
cgtggacgag gcttgggctt tgctgcaggg actgcagagc cgcgtggtgc 13980accacaccgg
ccgcttcaaa gagctcttcc acccatacgc cgagagcctg gtgagcggca 14040tcgggcgcca
cgtgcaggag ctgcaccgca gtgtggctcc gcacgccccc gccagccccg 14100cgcgcctcag
tcgctgcgtg caggtgctct cccggaagct cacgctcaag gccaaggccc 14160tgcacgcacg
catccagcag aacctggacc agctgcgcga agagctcagc agagcctttg 14220caggcactgg
gactgaggaa ggggccggcc cggaccccca gatgctctcc gaggaggtgc 14280gccagcgact
tcaggctttc cgccaggaca cctacctgca gatagctgcc ttcactcgcg 14340ccatcgacca
ggagactgag gaggtccagc agcagctggc gccacctcca ccaggccaca 14400gtgccttcgc
cccagagttt caacaaacag acagtggcaa ggttctgagc aagctgcagg 14460cccgtctgga
tgacctgtgg gaagacatca ctcacagcct tcatgaccag ggccacagcc 14520atctggggga
cccctgagga tctacctgcc caggcccatt cccagctcct tgtctgggga 14580gccttggctc
tgagcctcta gcatggttca gtccttgaaa gtggcctgtt gggtggaggg 14640tggaaggtcc
tgtgcaggac agggaggcca ccaaaggggc tgctgtctcc tgcatatcca 14700gcctcctgcg
actccccaat ctggatgcat tacattcacc aggctttgca aacccagcct 14760cccagtgctc
atttgggaat gctcatgagt tactccattc aagggtgagg gagtagggag 14820ggagaggcac
catgcatgtg ggtgattatc tgcaagcctg tttgccgtga tgctggaagc 14880ctgtgccact
acatcctgga gtttggctct agtcacttct ggctgcctgg tggccactgc 14940tacagctggt
ccacagagag gagcacttgt ctccccaggg ctgccatggc agctatcagg 15000ggaatagaag
ggagaaagag aatatcatgg ggagaacatg tgatggtgtg tgaatatccc 15060tgctggctct
gatgctggtg ggtacgaaag gtgtgggctg tgataggaga gggcagagcc 15120catgtttcct
gacatagctc tacacctaaa taagggactg aaccctccca actgtgggag 15180ctccttaaac
cctctgggga gcatactgtg tgctctcccc atctccagcc cctccctctg 15240ggttcccaag
ttgaagccta gacttctggc tcaaatgaaa tagatgttta tgatagaagt 15300ttgcctggcg
tgactctcat ttggaccatg tctgaaagca gtggcctcac cactatcccc 15360aaagcacacc
catcacccac tccattccct tgctgctctt tctcatccac ccactcccag 15420tccaggtctg
tcaaaggggg tctggctggg ctctgcttca gggatcctgg ctagacaacg 15480gctgtctgtc
acacctggca ggagggcctg ggttacgggc ccttcctctg cacctgcact 15540gttcactagc
ctgctccccc acaggacact gtgcatggaa tgcaggctgt gtctggaaga 15600gctgtggccc
tggtggacct aagattcctg aggtgggctg cctcctttgt tcctgctgtt 15660ctagagtttg
aatggcctct ttttatgccg gactctcttc tggggactcc cctcactcag 15720gggcaccaat
gctccctata gatcccctgg gaactgaaac tggggtgtgg tggaggacgt 15780ggaaagggta
aacacagctc cttgtctttg gacttccctg tccggccccc tttcctccca 15840gctcagccta
ctgtccccgg gttctcagca cctgcctgct ccccaacccc atagcacaga 15900ccccacacat
atgtaggctc atcatgcctg caggctggtc ttccctgaca ccgtggattt 15960tgacaatgtt
ggcaacagaa ctgggttgtg gacccagcac
16000526656DNAHomo sapiens 5tcgagctgtt ttacctaagc tttccactca tgattaacta
atgaagatta caatgattac 60atggtagaac ccatacacaa accactagac ctggcaccag
ggggttttgc aagaaagagg 120gtaagattct agctacatgc gaacagccca aatactctga
tcttaaactt acctcctttc 180tggctaaagg caggaatttc aaaatctagc tcaggaatcc
ttgtggcagc agagtcagtc 240ttcaccactt ctctgttcat gtcctgggaa gaaaagaata
cgttcagtac aaagagactg 300cagaacagct tctcctcaag taataaccag accgtcccct
tccatcagac cgcagcccag 360ctgtctctcc ctctcgccac tccacagggt ccagactgct
cctttcgaat agtacaggtg 420gtgtgagcca ggctgtccaa atggtgagaa tactattcat
aacaactact gctcatttca 480taccctcaga caacatttac aaagcatttt cacaaatctt
atctcacttg agctgatgac 540aacaccagta ccattttaca aaagaaacta aggctaggag
acataggggg atttatttaa 600gatccgaccg cctggaccag agctctgacc ccagtaccga
atctctctct agaatactga 660ggtacctgct ctgaggtcct ctcacctcca gagccctgac
agacaaagtg tagcgcactc 720cctggtcctg gatcctgcct gccgactgga tctccgtgtt
gttccagcca cagtgctcgc 780aggaaaagga gctcactatt atttctctga agaagggaat
cttggtgagc aggaggcgcg 840tcatgccctg gtgaagtaga aagtagctaa ggaaaaaaat
caatgaaact ccctttcccc 900gccctactat ctccgggcgc tcctcggggt ccccggccgg
gcccacctgg ctgggtctga 960cccccggctc gtcccggcac aagccctacc cacccgccgc
tcgcggccgc gcccccgcct 1020cacattgcag taacagttca tgcatagcga ctcgatctcg
gtgggctgct gctcctcgtc 1080ctcggcgctg atgggccgga acaggtgatc aggggcaggc
ggcggggccg gggcgggcga 1140cggggcgacg gcagcccccg ggggccctgg ttccacagcc
ccgctggccg ccatggccac 1200cacgcgcaat tcagacctcg gcttcctact tccgccgctc
tcgcggcccc acccctctcc 1260cgtcacttcc gccagctgcc accaccccaa aaaaagccgc
agactccggg cactcgggga 1320acaatgtcgt caagggctcc cggttcccgg gtttatatgg
ctcgaacctt acatcgccag 1380ccggatccac ctcaactcag ccgtcacttc ccctaagacg
tcctcttaga accagggcac 1440ttttttgctc cttcacaata gctccaccgc acggggttct
attggtccct acgtcggtct 1500acaagagcct tgacgacaag gggctggact tgtccctgag
gaatccctga gaaggtgcgc 1560ccggagccgg gctgcttggt tccagtgttg ggccacatac
tgcttgcgtg ctaggtcgcc 1620cctccgggtg gctcagcctc ttcccctctc tcacaatccc
tgaatccctc tgtccctttc 1680tgttcttccc actccctatt ctgtcctcat cactaccttc
cccaatccca gcctcaagta 1740cacagccctc attttcactc ctacctcctc atccccatca
tagcccttga cctatgcttt 1800tccagtttcc taacaacaac aaaaacacct tttattattt
ctacctttct agcacttcct 1860ctctccaggt gctgggtcca caacccagtt ctgttgccaa
cattgtcaaa atccacggtg 1920tcagggaaga ccagcctgca ggcatgatga gcctacatat
gtgtggggtc tgtgctatgg 1980ggttggggag caggcaggtg ctgagaaccc ggggacagta
ggctgagctg ggaggaaagg 2040gggccggaca gggaagtcca aagacaagga gctgtgttta
ccctttccac gtcctccacc 2100acaccccagt ttcagttccc aggggatcta tagggagcat
tggtgcccct gagtgagggg 2160agtccccaga agagagtccg gcataaaaag aggccattca
aactctagaa cagcaggaac 2220aaaggaggca gcccacctca ggaatcttag gtccaccagg
gccacagctc ttccagacac 2280agcctgcatt ccatgcacag tgtcctgtgg gggagcaggc
tagtgaacag tgcaggtgca 2340gaggaagggc ccgtaaccca ggccctcctg ccaggtgtga
cagacagccg ttgtctagcc 2400aggatccctg aagcagagcc cagccagacc ccctttgaca
gacctggact gggagtgggt 2460ggatgagaaa gagcagcaag ggaatggagt gggtgatggg
tgtgctttgg ggatagtggt 2520gaggccactg ctttcagaca tggtccaaat gagagtcacg
ccaggcaaac ttctatcata 2580aacatctatt tcatttgagc cagaagtcta ggcttcaact
tgggaaccca gagggagggg 2640ctggagatgg ggagagcaca cagtatgctc cccagagggt
ttaaggagct cccacagttg 2700ggagggttca gtcccttatt taggtgtaga gctatgtcag
gaaacatggg ctctgccctc 2760tcctatcaca gcccacacct ttcgtaccca ccagcatcag
agccagcagg gatattcaca 2820caccatcaca tgttctcccc atgatattct ctttctccct
tctattcccc tgatagctgc 2880catggcagcc ctggggagac aagtgctcct ctctgtggac
cagctgtagc agtggccacc 2940aggcagccag aagtgactag agccaaactc caggatgtag
tggcacaggc ttccagcatc 3000acggcaaaca ggcttgcaga taatcaccca catgcatggt
gcctctccct ccctactccc 3060tcacccttga atggagtaac tcatgagcat tcccaaatga
gcactgggag gctgggtttg 3120caaagcctgg tgaatgtaat gcatccagat tggggagtcg
caggaggctg gatatgcagg 3180agacagcagc ccctttggtg gcctccctgt cctgcacagg
accttccacc ctccacccaa 3240caggccactt tcaaggactg aaccatgcta gaggctcaga
gccaaggctc cccagacaag 3300gagctgggaa tgggcctggg caggtagatc ctcaggggtc
ccccagatgg ctgtggccct 3360ggtcatgaag gctgtgagtg atgtcttccc acaggtcatc
cagacgggcc tgcagcttgc 3420tcagaacctt gccactgtct gtttgttgaa actctggggc
gaaggcactg tggcctggtg 3480gaggtggcgc cagctgctgc tggacctcct cagtctcctg
gtcgatggcg cgagtgaagg 3540cagctatctg caggtaggtg tcctggcgga aagcctgaag
tcgctggcgc acctcctcgg 3600agagcatctg ggggtccggg ccggcccctt cctcagtccc
agtgcctgca aaggctctgc 3660tgagctcttc gcgcagctgg tccaggttct gctggatgcg
tgcgtgcagg gccttggcct 3720tgagcgtgag cttccgggag agcacctgca cgcagcgact
gaggcgcgcg gggctggcgg 3780gggcgtgcgg agccacactg cggtgcagct cctgcacgtg
gcgcccgatg ccgctcacca 3840ggctctcggc gtatgggtgg aagagctctt tgaagcggcc
ggtgtggtgc accacgcggc 3900tctgcagtcc ctgcagcaaa gcccaagcct cgtccacgcc
ccccagcaac tgggccttgg 3960tgtcttcccc caccacgcgc aactgctcct gcagctcctg
cacgcgcagg gccacctgct 4020ccatcagatc catcgtgtag ggcttcagtt gctgccgcaa
gccctccaaa ttccagccca 4080ccagctcgtg cgcctctgcc atgtagggct ggaggcgagc
cttcacctcc tccaactcct 4140cctgcagctg ccgccgcatg cccaccgggt cctgtgggag
ccgaggagcc tcgctcccac 4200tcagaggcct cagcttttcc aggaacttgt tcatattgtt
gaggtcttgc tcaaggctgt 4260ctttcagggt cctggagaag gggacagata tccaggccgt
cagactgcta gcccccatca 4320tctcctttgt ccccaagtca tcgcgcactg atcctctggg
ggaaccaagg acgcagggcg 4380ttggccccag ggtcgagggc tcttgtccta gccctggcca
gtaacaactc acgcacgaag 4440cacaaacaca ttgcccatac aaatccagac ctacaacact
ctccaaagaa acatagatgc 4500gccacatcat cctttgattc tggggactgc agcgggcgtc
ctcccgattg atcccaggtc 4560ccgcgcctca gtgagcaagg gggcaacagc tacggagttg
tcaaggcggg ggctgcaggc 4620agagggcgct aaagagccca ggatggccgg gatctgcaga
cagagctagc accgctcctt 4680tcctctgtcc cagcagcggc cacagaggtt gaggcagcag
aggcaggtca tcatggcatg 4740gcccagctgt ctcctccctt cgcctacacc ccttcccctg
ggcactcacg cgggctcgcg 4800agccatcttc tgctgatgga tctgctccac cctgcctttg
tccccgctgg tctggctgaa 4860gtagtcccag aagcctttcc gtgcctgggt ggccgaaaac
gctgtggaga gggactaggt 4920aatcagggcc tgggctctcc tcccccaggg tggacagggc
cctctggcca gcctccaccc 4980acacccccac gttgaagtca gggtcggaga cccacctgaa
agaagagcca gagcccaggt 5040gagcacggca gccatgcttg ccattacctg ctctgagaag
acaggtggag ggaggcctgg 5100ttaggggaag aaggagacga agggacatgg cgcaggggac
ttgcccaggg ggcctctgca 5160ggggcaactg cccgaaatcc tgttacccct tccttgggct
ggggagcaca gagctgttgg 5220ggctcaagag gactgaccta ggtgagtcaa ggaggctagg
gtgtcttcct caaacatggg 5280aagagggcgt gctcttgcta cctcagtcac atagcaggga
gcgtggtgct ctaacccctt 5340cgcaaaggtc ccagacccca ggaacagttc tctaggccac
ttctaccacc tctcccctgc 5400ccacctgtct ccctccctcc catttcatgg tggaaaaact
gagccataat gagggcgaag 5460aggcaactct gccaaaatgt tccaagagga cgtcttaggg
gccaccccag gctctcccct 5520gaggccacct gcaatgccct cccttaggac tgtgaccccc
atccctctgc cccagctgct 5580cacctgctca cgtctgggca cagagagcag acattctgct
ttatactcca gggccctgag 5640cctctggcac caattgctct gagtaaatac cacgtggaag
ttcaaaagaa gttgacctca 5700gctgcctccc agcactcacc tcctgccctt tccctggcac
ccagagggtt aatgagtgcc 5760ctggtatcag gggctgcccc agtagagaag tgcttcccag
gagctttacg ggggatgggg 5820ctgaactcct cacccagttt ctcccaaacc ccatgacctt
taaccttccc actgacctgc 5880tggctggccc accaacagag aagaacctgt ttgtctgcca
agggcccctc tcttacacaa 5940ctacccagag tcactgtgtc ccagccggca agatggacag
tgttcaccta ccagccagaa 6000cccgagcagc ccctgaaagc ttcactacag gttccgcagg
catcctcagc cagcattcat 6060agggttaaag accaaccaca tccctcttta tgaaacaatc
ctggaacaag caagggaagc 6120caggcagggt gaagatgaga tggcaagagg catctgggcc
agggactctg agccccagga 6180actggagcga aagtgagatt tgccccatga ggaaaagctg
aactccactc gcagggcctc 6240tgaggagagc aagcccaaat gctcagatct tctctgatga
cacacccact ccgtctacag 6300tactcataca cacgttcaca agctcccgat tcttggtcct
aaatgcatct tgaatcaatc 6360ccctctcctc catttccact accatcattg caccagttgt
ctgtcacctt gattgcattc 6420atagcctcca acaggtcttt ctaccacact cctgcccatt
taattcatcc tccactgtgg 6480ctcatcctga ctcatttcca gtctcatctg ctgccacata
aaaccacagc attccctgag 6540cctttataca ggcttccctc tgcttgaaat agcctatccc
ctggtgaata tatattcatt 6600ttttagagtt agtttgtatt agttagaatt agacttggct
gcaagggaca tatatatgtg 6660tgtatatata tacacacaca catgtatatt ttatattctt
gcatacatat atgtatatat 6720atgtgtgtgt gtatatatac acatatatat atacaagata
ctgctcttac cactcatact 6780gacatcccat tggccacaag ttagtcacat ggctacactt
agctgatata tatgtgtata 6840tatatatgca agagaatagc ttaaacaaaa tggagtctta
tttccttctc atgtaaatgt 6900aggccagctc gggctgcttt tatcttgttg cactattatc
atcaacaaga cgctcatatc 6960caagttccag ctgcttcacc tccagctacc aagttcacct
cccagggaac aggaaggagg 7020aaaaggagaa ggacatgttc cttcctttta aagacacatc
ccagatattg ccattaccac 7080ttgtactgac atcccattgg ccacaactta gtcacatggc
tacacttagc tgaaaaggag 7140gctgggaaat atagttttta ttttggatgg ctgtatgcct
agctgaaaaa ggactctatt 7200actcaggaag aagagaagaa aggatttgag ggaacagtag
tagcccctgc tacacagctc 7260cagtatcact ctgaatgcct tcttcggcct tcaccttttt
ctgctctgga gataaactga 7320ttccacatta ttcacacaac actgtatatt cctggattat
agcacttact atctaactgc 7380acaataattt gttgatgaat ccgagagctc tttgagtgca
ggggcttttt cttattcatc 7440tctatatcca ctagtatgtt ttgcacagtg cctacctact
acatacaaag ttaagtgact 7500gaattcaatc attcatttga tttaggaact gaggtttgag
gagatcaagt ggcctgtcca 7560tcatcacgca gtaagagttg caaccagaat cagaacccag
gtgcttggct ctggtggttc 7620aagagagcag actatgacca agtcacaaag gggcttgtgc
aagcagtcac tgaaaggtac 7680atgatggaga gatcactcag gagggtggcc agagagaagg
cagaggaact atttagggat 7740attttaataa tccaagtgag aaatgaaggc ctgaagtatg
gcatagcagt gatggttgat 7800aggtaagtat atattgaggg ctactaaggc agcagagttg
atagcacttg gtgactgatt 7860ggatgaggaa ggtgaaggag aggaaaaaat cccaatgatt
cccaggtttc tgagcaacta 7920gggggatgat attttctttc accaaaaaaa ataagcaggt
tgggacagga agtgagagct 7980cagattaaca ggagtcctaa ctcgaaccta agctgggttt
cagataggca tagggcaagc 8040ccagttgagg tctatttgct taatggctaa gaagcctcct
aagagaaaat tcatttgaaa 8100ggaaaaaaag caacaggagc taccatccag tcacaaaacc
acagtcatca aaagagaaga 8160gagactcaga gtatttggga agggaacatt tccaggggtt
gaaaaaatgt gggagtggag 8220agccactgaa attgactttg ggtgattact tgtacccaca
agctagtgtg gccttgtgcc 8280caaaggctgt ccactggaga tgttctggca gttggataca
tatgtctcaa gcccaggaga 8340gaagtctcgg ctggagactg agttttggga gtcatcagca
gataggagca gtggaagact 8400tgggagtaga tgaaatctct agggagagta catggcagga
gaaaagaaaa acgctgaggt 8460cagaaaacac cagtattggc cgggtacagt ggctcacgcc
tgtaatccca acactttggg 8520agaccgaagc aggcggatca cttgaagcca agagtttgag
accagcctgg ccaacacggt 8580aaaaccctgt ctctactaaa aatacaaaaa aaatagccag
gtatgatggc acacgcctgt 8640aatcctagct acttgggagg ccaaggctgg aggagtgctt
gaacctggga ggtggaggtt 8700gcagtgagct gagatagggc cactgcactc cagcccgggt
gacggagcgg gactccattt 8760caaacaacaa caacaacaaa agaagccttt ggcagagaaa
attaacgctt tccaaagatc 8820catgtgctgt gctgtacttc ccagactcct ttgcaattag
attggggcca tacagttagt 8880tctggccaat gggctgtgag cagaacaaaa tgggttactt
ctgtttgagg acaatgaaga 8940gtggatgtga gttctccata ttttttcctt ccttccccta
cagtggaagc aaagaactcc 9000aagctggcac tattacaaga gggagagggt ctatattctg
agttagtgct tggagcagca 9060cctcccacct aaaagagggg cagagaagta gaagtataat
caaaataaag aagaatcaca 9120gaaagaaaat atattagtta aattatatat ttggctgctc
tgagagagac ccaaaataac 9180agtggcttac aaaagctgga aatgtatgtt ttctcccata
caaaacttca cgctggtatg 9240ggagcactgc tccacaaagc tgtccagggt cctaagttcc
ttctgtctgg aggttctaat 9300atccctatgt gtttcccttg tccacatgat ctaagatagc
ttaccaccat gtccacatcc 9360agccactgga aagggggcag ggtggaggag aggagagtgt
agaatgtact ctcctttctt 9420tctttttttt tttgagatgg agtttcgctc ttcttgccca
ggctagagtg cgatggcaca 9480atctcggctc atcacaacct ccacctccca ggttcaagcg
attctcctgc ctcagcctcc 9540tgagtagctg ggattacagg catgcgccac gacgcccagc
taattttgta tttttagtag 9600agacgaggtt tctccatgtt ggtcaggcta gtcttgaact
cccggcctca ggtgatccgc 9660ccacctcggc ctcccaaagt gctgggatta caggcgtgag
ccactgcacc cagccactct 9720cctttctttt aaggacaaaa cctaacttct tctcccatct
cactggtcag aactacttgt 9780aaggaaggtt aggaaatgtc atctttgttt tgaatgggcc
tgagttcaat gatcagttaa 9840aaatcaggga ttctaccctc atacattgct ggtgggattg
tacaatggtg caatttcttt 9900ggaaaacagt tcggcagttc attaatggtt aaacatggag
gagttctcct atgactcagc 9960aattctattc ctaggtataa aaccaagaca catgaaaata
cacatctgca caaaaacttg 10020tgcattaatg ttcatggcaa cattattcat aacagtcaag
aaaatggaaa caacccaaat 10080gtccatcaat tgatgaatgg ataaacaaaa tgttacctat
ccatatagtg gaatattatt 10140tggcaataaa aagggttgaa gtactgatac ctgctacacc
acagatgaac ctggaaaaca 10200ttatgctagg ggaaaaaagc cagtcacaaa agactacatg
ttgtaaaatc tcatttgtat 10260aaaatgtcca gaaaagacaa ataggtagag acagaaagta
gactggtggc tgcctagggc 10320tattgagggg aggggaggtt gattggggag aaatagtgaa
taactgctaa tgggtgtggg 10380gtttctttgt gggatgatga aaaaagttct aaacttagtt
tgtggtgata gttgtacaaa 10440tctgtgaata tactaaaaac cattcaattg tagtgaatgt
tatggtatgt gaattatatc 10500tcaataaaga tatttctaaa atcagggatt ttataactga
gaaagaaggg aagaataaag 10560ttgcagagga gacttgcagc ctctgccaca ccaaggacga
aaaggtttca agagtgaaga 10620attaatggct tcccaccatg gcagactgag ctgagctgag
gctgtgtttt caatgctttt 10680ctatctctac tctttttttt tttttttttt ttttgagaca
gagccttgct ctgtcaccag 10740gccatacagt ggtgtgatct cggctcactg caactaccgc
ctcccgggtt caagcgattc 10800tcttccctca gcctcccaag tagctgggag tgcacaccac
cacacccagc gaatttttgt 10860atttttaata gagatggagt ttcaccatgt tggccaggct
gatctcaaac tcctgacccc 10920aagtgatccg cccacctagg cctcccaaag tgctgggatt
acaggtgtga gccatccccc 10980tggcctctat ctctactcct aaaagaacca tttctgacca
cttaacaccc attagaatgt 11040tattttaaaa aataaaataa aagccaaaaa tagcaagtgt
gggtgaagat gtggagaagc 11100tggaccgctt gtacgctgct gctggaaagg taaaatggtg
cagctatggt ggagaacaat 11160acggcagtcc ctcaaaaaat ttaatctaga attaccttat
gacccagcaa ttccacctct 11220gggcatatat ccaaaagata aaagcaggga ctggagcaga
tatttgtatg ctcgtgttcc 11280tagtagtatt atccacaata accagggggt ggaaacaacc
caaatgtcca ttgacagatg 11340aatgaataaa caaattgtgg tatatacaga caacaaaata
tcacttagcc ttaaataatg 11400acaatcgggg gccaggcata gtggctcacg cctgtaatcc
cagcactttg ggaggccgag 11460acgggcagat cacttgaggc cggaagtgca agaccagcct
ggccaatatg gtaaaacccc 11520gtctctacta aaaatacaaa aattagccag gtgtggtggt
gcatgcctgt cattccagct 11580acttgggagg ctgaggcacg agaattgctt gaacctggaa
ggcagaggct gcagtgaact 11640gagattgtgc tactgccctc cagcctgggt gacagagcga
gactgtgtct caaaaaaaaa 11700aaaaaagaaa agaaaagaaa aggaaatctg acacatgcta
taacgtggat gacccttgaa 11760gacatgatgc taagtgaaac aagccagtcg tagaacgaca
catactgtga ttctgaggta 11820tccagaatag tcagatttgt agagacagaa agtataattc
tggtttctag gagaagtgag 11880gaaggagaag gtattggtta ataggtacaa gtttctgttt
gggaagatta aaagtttctg 11940gagctagata gtggtgcaca acagtgtaaa tgtatttagt
gctactgggc tatatactta 12000gctacaatgt acaatagcta caatggtaat ttttatgtta
tgtatatttt gccacaattt 12060aaaaaggaat ttctcatact ctaatggttt tttgctgata
acccaaactt aaagagcctg 12120tgctgtaaaa tacaactgcg ctggattgtc tttttgcaaa
tagcattatc agtgcccttt 12180ctaaggtctt ttatgagatg cagaggggac acttggaact
attaatacat tttctagaat 12240cccttctcta tatgagccta ggttagagtc agccagcgtg
agacggaaga ggagaggcca 12300ttatgtttca atgccggttg cagacagaag catggacagg
cttggagttt aaagcagctt 12360ctgggtgacc ttcccaggaa tcacatgcat tgatattgca
ggcataataa ggcgagcttc 12420ccatttgtag ccacttacta atgagcgttt gagagtcact
ccttctgaac tgcaaaccaa 12480ggtggtcact cctccagccc ttccaagagt tggataaacc
tttaattttt tgttttaaag 12540cctttcatgc ttgaaatacg tggaatggct tttgtttttc
tgactgaacc tggattgata 12600caatgggtag atgcaacaca cactcatgct tccctgtttg
gtggcatctt atagtttcag 12660tgttgaacat gttttgagtt ggttggaggt atatgtatat
gtgtatgtgg tatgtgcttt 12720gtgtgtggaa ccatttgaaa taattatagc caacatgaca
cttcactctg aatacttcaa 12780catacattgt gaaaaataag gactctttta caaaagaaaa
aaacattatc atacctttga 12840aaattaacac aattccttaa tatcatctaa catatcctac
atattcagat tttccccaaa 12900atgctttcat agttgttttt ctctctctgt aaattcaagc
tctaacacat ctcatctggt 12960tgttatccca ctttagtttt taaatttaga accgttctcc
ccaaccccac catttgtttg 13020ttttcatgac attgattttt ttttggaaga gtgcaaggag
gacatcttgt aaaatgtccc 13080acattctgga tttgagtgat tactttctca tgattagatt
aaggttaaac atttttggca 13140aaaatactag gtgatatctg gcccttctta ctgtatccta
gctggaggtt gcactctatt 13200tagtgatgtt aagtttgatc actccattaa agtgataaca
accagatttc tccatggcta 13260gtaaagtttg gttttttacg ttattgataa gtaatttgtg
gagcaatact ttgaagccat 13320gtgagcatcc cattctgcaa caatttttca cccaatggtt
ttagcattca ttgatgatcc 13380ttgcctgaat cgaatattat cctgagagtt gccagatagt
gatttttaaa aaattctagg 13440ccaggtgcag tagctcatgc ctgtaatccc agctctttgg
aaggctgaga tgggaggatc 13500acttgaaccc aggaatttga gaccagcctt ggcaacatgg
caaaacctgt ctctacaaaa 13560aaaaaaaaaa aaaaaaaaaa actaaaaata aaatacaaaa
attagcctag catggtggca 13620cacatgcttg tagtcccagc cactcaggag gctgaggtgg
gaggatcacc agagcctggg 13680aggttgaggc tgcagtgagc cgtgatcaag ccactgcact
ccagcctggg ccacagagtt 13740gcccaaaaca aaatgaaaac ttaaagaatt ccatcattcc
agctacattt attatccgat 13800ttcttctgta agtaagagct tttagggaac ttgttcttaa
atccagagac tttgaacaga 13860ttccttccag gtgaacttgt ttgtgctgcc ctttccttga
ctgtcgtttt gtatcacagt 13920gtttgcggat agctgcattt ttaagagagt tgcccctcta
ctttgttttg tgtttttgtt 13980ttttaataca caagaattgc tgactcattc tggatgtgta
gtaagaagga ttttaaaatg 14040tagattggta aaggttagca ggtaccttat tccttactgc
tcagcagcag cacttttgcc 14100ttaaacacat ggattaagca agtgtatggg tctcaaatag
acacttgata tgcaccaagt 14160gagaagatct tctagagtct ttcttttgtg acctgttctt
taaagcaaca ttatgacttc 14220tccttctgaa cagtaagtat tttttttttt tttttttttt
ttttggcaga gtctcactct 14280gtcacccagg gtggctggag tacagtggcg tgatctcggc
tctcggcaac ccagtcactt 14340gggttcaagc gattctcctg cctcagcctc ctgagtagct
gggattacag gcgtgtgcca 14400ccgtgcctgg ctaatttttg tatttttagt agagatgggg
gttattccat gttggccagg 14460ctggtcttga actcctgacc tcaggtgatc cacccacctc
ggactcccaa agctcccaaa 14520gtactgggat tacaggtgtg agccaccaca cccgggccaa
gtaaatcttg ttacaaattg 14580ttctccttca gtcttgtctt ctaagaactc agatgtaaac
tgtgaggtag cagtctttac 14640ttggtgttcc tggactccat ctcagaacgc accaaaaaca
tctatatgat tgtggagcca 14700ctctacattg tttctactgc tatcaccaga ccttaatgga
ggtgtgggtt ttttaaaaat 14760caatatacat ctcaaataca tttcagaaag aaaggtgttt
atgcttaacg cagtgttaaa 14820actatcccag caagaaagta gtaacctgtg taagcatttt
tttgtttctt tgcttgtttg 14880tttatttgtt tttgagacag gatctcactt tgtcacccag
gctagagtgc agtggcatga 14940tcacagttca ctgcagcctc aacctcccag gctcaagcaa
tcctccagcc tctgcctcaa 15000gcaatcctcc agcctctgcc tcccaagaat ctgtagtttc
tgggactaca ggagtgtccc 15060acaacaccca gctgattttt tatttttttg gtagagaaag
gatctcacta tgttgcccag 15120gctggccttg aactcctggg ctcaagcaat cctcctgcct
cagcctccca aagcactggg 15180attacaggca tgaaccacca tgcctggcct tttgtttgtt
ttgaaataag ttctatttgt 15240caaaaagaaa gagaattaaa tagaacatct ataagtgaaa
aaaatatagt cattataata 15300taaaacacat ttagctacag ttggagagag aattagtaag
ctagaaggta gatctgagaa 15360aatcacacag aaagaatcac agaaataaaa aggaggatat
tgaccaggca cggtggctca 15420tgcctgtaat cccagcactt tgggaggccg aggcgggtga
tattggccag gcatggtggc 15480tcatgcctat aatcccagca ctttgggagg ccgaggtggg
tggatcacct gaggtcagga 15540gtttcagacc agcctggcca atatggtgaa accccgtctc
tactaaaaat acaaaaatta 15600gccgggcgtg gtggtgcatg cctgtaatcc cagctacttg
ggagactgag gcaggagaat 15660agcttgaacc tgggaggcag agtttgccgt gagccaagat
catgcaattg cactccgtcc 15720tgggccacag agcaaaactc tgtctcaaaa aaattaaata
taaaaaggag ggtatgaata 15780gacggtaaga gacatggagg acagaatggg aggtccaata
tatgcctgta ggatttccac 15840gaagagaaca cagggactgt ggaagaggca atattcaaaa
gatgatggct gagaaatttc 15900aaacattgaa gcaagatgtg accggaatcc tcaggtacag
gaagcatcct gagtcttggt 15960aggaaaaatt aacacacaac caaatgagga cacatcacag
gaatctgcag aacactgaag 16020gcaatggata tcttaaaatc aaccaaagag aaagactaat
gatctacaca cgaagcatga 16080ttaaaccggc aactgattta tcatcaatgt accttctaaa
gactgaaagg aaattaatgg 16140ccaaccaaga cttatactca ggtgaactat tatttgagag
gaagaagtta atttcagaga 16200aagagagttt accactcaca gatcctcact gaaaagaact
actaaaaatc tgaaaaggaa 16260acagaaccca gaaaaaagga ataggataga aggagacatg
gggagcaatg aaattagtaa 16320acgtttaggt aaatccaaaa aacattagtg aaaatacaca
cacacacact tatgagacta 16380gttttcacta aaaattggtc aaatagtggc aatttcatat
agttctacct aacaaaaatg 16440tatttacaca tagtttagtt tgtgggggtt ttgtttgctt
gtttgtttgt ttgttttttg 16500agacagggtc tcaccgttgc ccaggatgga gtgcagtggt
gtaatcactg cagcctcgac 16560caccctgggc tcagatgatc ctcccacctc agtcttctga
gtagctagga ccacaggcat 16620acaccaccat gcccagctaa tttttatatt tttttgtagg
gacgggggtc tcgctatgtt 16680tcccaggctg gtctcgaact catgggctca agcgagctgc
ccgcctcggc ctcaaaagtg 16740ttgggattac aggtgtaagc caccctacac ctggccaagt
ttatctcatt tcctactgta 16800ctcccagtgc ctagaccagt gcttatcaca tggtagggag
ggctcaaaaa catctattga 16860tgaagggact actttggagg aggtgttaaa agtaatgagg
aactaaaata tcagaccgaa 16920gcaacctgga aatgggaaag gagagatcaa agtgaaagca
ttcagcagcc tttgcattat 16980tcgggagaaa gatagggata ttgattatct atagactttg
ttaggtcaga caagaatatt 17040aaaattttaa ggataaccca taaaacgaat agaaagaatg
gataactttt aaactagtat 17100atggggaaga gagactaaag agcatccgat tgacttctag
taacggacgg tggattaatt 17160gcatgcatta gcctctgctg ttctctgaaa tctcaataac
gtggcattga agtgcacttt 17220ttacaaaatg cataaaccca aagggaaaat agaaaaggag
acaaaaataa caacatttgg 17280gaagctggaa agcttccaaa tggtcaaacg gtggtgacag
gcacacctga catgaatttt 17340gaagcagcag tggagaaagc caagaaggcc cctgattttc
actactaaac tctccaaatg 17400ctctgacatt agtgtcaaca ttcttctgga agagtgggtg
gcagtgggac tagaaatatg 17460gcagttggtc gagagtctgt ttgagaagca gctgttctct
tcaactctac ttggctgggt 17520acccccaaag cagcagaaaa ccagatgctt attctctctg
aaaagggtaa aagagtggga 17580ctccggcctg gagaaaacta ggtattgttg ggggccaggg
tttttgtgct aagaaaaatt 17640aaggaaaact ttatacatta aattttgagg ctgggcacag
tggctcatgc ctgtaatccc 17700aacactttga gaaggcaagg caggaggatc gcttgagccc
aggagttcga taccagcctg 17760ggcaatgtag cgagaccctg tctctgcaaa gaatacaaaa
attagccagg tatggtggca 17820cctgtggtcc tagctactca ggaggctgag gcagaaggat
tacttgagcc cacgagttag 17880agaccgcagt gagccatgat catgctactg ctctctagcc
tgggcgacag aatgagaccc 17940catctcaaaa ataaattttt ttaaaagact cctcagttca
ccatctttcc ccatattgaa 18000aatggaacaa cattctccct gagaaatttg gctggcccaa
ggaaataagc ctaaagaaac 18060tgacttttgg gggttccctg ctctccagat ggtccctcct
aaattgaacc atggactcag 18120gatttcacat cagcttcttc taatttatgc agctttcttc
taatttactg tggggttttt 18180tcggtgtttt ttgttttgtt ttgttttttg agacagggtc
ttgctctgtc atccagctgg 18240agtgcagtgg tgtgatcata gctcactgca gcctcaaact
cctgggctca agtgatcctc 18300ccacctcagc ctcctaagta gctggggcta caggcatgac
caccacacct ggctaacttt 18360ttaatttttt gtagaggtgg gggtcttgac atgttgctca
ggctggtctt gaaatcctgg 18420cctcaagcga tccccctgcc tcagcctccc aaagtgctgg
gatttcaagc atgtgccact 18480gtgcctggct aagaatactt aaaggtgaag tgagaagttc
acatgatgtc atatcaggag 18540gtacacaatg gctacttgtc ccactaatag caatccttag
ttttttcact tcgtgaggtg 18600gtcactagca gacctcttgg ttggaaagat aggttatttc
cctttgtaat taacaagtaa 18660cagaattggg atactttggc atcttaaaat accttggcaa
cctgatgaac atagcataca 18720ttcaagattt ttgcctgaat taattattac attagaagag
ttgcagaatg agaatgttct 18780aattctacta tttcttttat atatttcagc tgatgttatt
ctatgaagaa aagctccctc 18840atcagtgaag atgaactgca cttctttcta aagaggcaat
gtcagacggg cacggtggcc 18900tataatccta gcactttggg aggccgagga gggtggatca
cctgaggtca ggagttcgag 18960accaacctgg ccaacatggt aaaaccctgt ctctacttaa
aatacaaaaa ttagccgggc 19020atggtggcac atgcctgtaa tcctagctac atgggaggct
gaggcagaag aatcgcttga 19080acctgagagg cagaggttgc agtgagctaa gattgtacca
ctgcactcca ggctgggtga 19140cagagtgaga ctctgtctca aaaaaaaaca aaacaaaacg
aaacaaaaaa acagttgaca 19200gtagttgttt ttgtagagtg aaaaatagag gtgggggttg
agatactgct gctattttaa 19260actaacttgt agatctgttt gactcttttt taaaaaacaa
ttttttggag agatgaagcc 19320ttgctatgta gcccgggctg ctctcaaacc cctggcctca
agtgatcccc ctgtctcgac 19380ctcccaaagt gctggggtta cagacataag tcaccacacc
tggctctgtt tgactcttta 19440tgtgcagttt gaacttttta actgaatttt ttaaaaggtg
tgaaattagt ctttaaagga 19500acacaaaacc aacagagaag caagcaggaa gatacaagaa
gcaaagaaat atcatagtaa 19560aatgaaaata caaaataata tgacataaat aaaacagtaa
tcactatcaa attaaataga 19620ttaagtgagc ccacaaggca ttgtctctgg gactagtccg
ctgggtcgaa gtcctgccac 19680ttattggttc tgtgaccttt ggcaaattat ttaacttctc
tgtgattcca tttctttctt 19740ttgttttctt tctttcgttt ttttttttga gacagagtct
cactctgtca ctcaggctgg 19800gtgcagtggt gcaatcacca atcacaactt actgcagcct
ccacctcctg ggcccacgcg 19860atcctctcac ctcagtctcc tgagtccctg ggaacacaga
catgtgccac cctgccaagc 19920taatttttaa attttttgta gcgattgggt ctcactatat
tgcctaggct ggtctcagac 19980tcctgagctc aagtgatcct cccgccttgg cctcccaaag
tgctgggatt acaggcatga 20040gccactgcac ccagcctcaa actctgtaaa aggggaataa
tgataatact tgcctcatag 20100ggcttgtggg aaataatgct ttattactgt aggttaaaaa
gcacacaaac atgcttgaca 20160cagtaggtgc tacatcagtt tactattgtt gttgttttca
gattggattt tataaaaact 20220ctacttattt gcaatttata agaggcatac ctaaaatata
atgtcagaga aaggttaaaa 20280agtggagcca gggaaggaat ttaagaagac ataccagacc
aatagtaatc aaaagaaagc 20340aggtatgcaa tgtaacatca gaacaaataa gctttgctta
tttggattga tagggataga 20400taggattgat agggataaag cagatcatta tttaatgatc
aaagaagaaa tttggctggg 20460cgtggtggct cacacctgta atcccagcgc tttgggaggc
cggggcaggg ggatggatca 20520caaggtcagg agtttgagac cagcctgacc aaagtggtga
aaccctgtct ctactaaaaa 20580tacaaaaaat tatccgggtg tggtggtgca tgcctgtagt
cccagctact caggaggctg 20640aggcaggaaa atcatttgaa ccggggaggc agaggttgca
gtgaactgag atcgcaccac 20700tgcactccag cctgggtgac agaataagac tctgtctcaa
aaaaaaagaa aaaagaagaa 20760gaagaataaa ttcactggga agataaaaca attctgaacc
tgacaacata gtctcaaaat 20820acgtaaagca aaaagccact gagtcccaaa gagaacttga
caaatttggt aggagatttt 20880aataccattt cctcaaactg atggaatcac agaaaaaaaa
tataagaaca agtcagcaaa 20940cttgatatgg aaagaacagc atccccacct gagagtcagc
agcctccatg caggaggacc 21000gaggggaagc cagggagcag ggcagcctga gccaaggcca
agcccagttg aggacaggaa 21060gtggaaggag gcacctagga aggctgaaga tgcagaggag
tgtgttccag aggcagtggg 21120aaaactggga gggaatagtt ctcgggatgt tggatagaga
gaataagcaa agaacaatgc 21180aggaagaaga gtggggtggg aggccgtgac cttgctagag
agccttatgt tttgggctat 21240gaccagggct gacagaagtg tgaggcatgg cgggttcaga
agagagatca atgatgcatc 21300gcacatctct aaagctgatg aaggcagcaa ttggcactga
ggccaacctg gttgggactc 21360agagaggtgg gacacatatt gtgtgccagg caccctgcca
catcttggag agaataagac 21420acaaaccctc atctagtggg ttggggaaat gatgcagggc
tcagtgtggc tagcgcgttg 21480gggtgggaag cagcctgggc acgcccacaa ggctctctgc
cttccagaat ctggcccagt 21540tgggtttgaa aagatttaat gacaatgagc tctctatgga
cctaccttgt gcccagtatt 21600tacctttctt atctgtaacg ctcaagtcaa tactctaagg
taggaattgt tatcctcatt 21660ttatttacag agaaactgga gttcagagag attcttgccc
aaggtcttgc cctgggccaa 21720ttccaggtct atctaactcc aaagtccatg ctcagtacac
tgtctcctgc ttgggagcaa 21780agagaggact ttgctcctaa gaccagaccc ataccacaaa
gagcctcaac acttaactac 21840tgggagaaaa caccgtccta agtaaaaagc caggtgctct
tccccttacc ccagggggtt 21900taggatttgg gagaaagagg cctgatggaa tataggggta
ccaggtccat gtgttaactg 21960atctgggtac aagaacagta actcaaggcc agccagggaa
agaacagcca agccgaggca 22020cagctgccaa gtcatcacct ctcgttcctt gtcccaccat
gccttgtctc agcacgaaca 22080taaccccctc agtttccctc ttctcctgtc tcctgcatag
gcagaaccag ttctgagtga 22140tagccaggac agcaggtcct cgggtcctca ggcttgccac
tacaacctgt ttaccctgcg 22200cagaccatga tccatcaggt cgagaaatgc cccactgcta
gatgtttgtg tcaaaaatgc 22260ctgccggtgg tgcaacagct gggtgggacc agtgacgtgg
acttgagtgc cacaaaatgt 22320accgaacaca ttctgagtca acatagtgat ggtgtgccaa
ctccagataa agattttcat 22380tattatttgt ttgggttttg tttatatgta ctcctcttca
tcaccaaaga tttgaggcta 22440cagaaaatga aaattgaaat ggtaataaaa gagaggggct
tgcagagagg accacaggat 22500ggggaaaata gaaataatcg cagaaaatca tgacccgatg
aagagcacaa tcatagaagc 22560actaacagat gacaaggttg ccagatcttc accattggtt
ttgggtttcg tgaaaacccg 22620cgaagagagg gattcagtca attacatatt ttttttcctt
ctttctttta tttttatttt 22680ttattttttc ttgaaatgga gtctcattcc gtcaccaagg
ctggagtgca gtggtgcaat 22740cttggctcac tgcagccttc acctcctgag gttcaagcca
ttctcctgat tcagcttcct 22800gaatagctgg gactacaggc atgaaccacc atgcctggct
aatttttgta tttttagtag 22860agactgtcac acgcgagaca gggtttcacc atgtttgcca
ggctctcgaa ctactgacct 22920caagtgaccc gcccacagca gcctcccaaa gtcctggaat
tacaggcatg agccaccgtg 22980cctggcttgt tttaattttt tattataaac aacactgtga
tgaacatcca catagctaaa 23040tgcatgcatt ccatgatcat tttcttaaga taattttttt
cttattattt gtgtatttat 23100ttatttattt ttgagacgga gtcttgctct gtcacccagg
caagagtgca gtggcacaat 23160ctcggcttac tgcaacctcc acctcccagg ttcaaacaat
tctcctgcct cagcctctta 23220agtagctggg atacaggcac aagccaccaa gcccagctaa
ttttgtattt ttagtagaga 23280cagagtttcg ccatgttggc caggctggtc gccaactcct
gacctcaggc aatcgcctgc 23340ctcggcctcc caaagtgctg ggattacagg cgtgagccac
ctcacctggc cttaagatac 23400atttttgaag ggaagaacat tttctgtcca agtacattcc
tgttcacaaa cccttttcca 23460taacactgga gacttcctgg ggaggttgga accaatggct
tagactccaa aggaatgaat 23520gtaccataaa gctttcagca atcttctgtc aatgctactt
gtatagactt ccagacaaac 23580attgaagatt gaatgcatgc atctaatttc actttttttt
cctgaaatcc tcctgaaact 23640ataatgaaga aatgtttggg aaaagatgta gccaggcact
gtggcttatg cctgtaatcc 23700tagcactttg ggaggccaag gtgggcagat cgcttgagtc
caggagtttg agactagcct 23760gggcaacatg gcgaaaccct gtctctactg aaaaaataca
aaaaatcagc caggcatggc 23820agacctgtag ttccagctac tcagggggct gaggtgtgag
gatcacttga gcctgggagg 23880tagaagctgc cgtgagccct gattgtgcca ctgaactcca
gcctgggcga cagagtgaga 23940ccctgtctca aaaaacaaaa aaaaaaaaaa aaaaaaaaag
agacgggatc gggaaaagga 24000agaaaagacc acagcacaat tttggatgtt agaaagcaaa
tggaccagtt gtaactgatt 24060tagccggcct tgggaatgct ggtcatgagc tggcagtgag
aaaagatgag ttccagcctg 24120acttacaccg ctggattctc aaaaggcgaa gagatgatag
tagggctcct gccagcccac 24180gctgcacctg tgtgtgcaat agaaacagcc tcccctttct
caagacactc tacagccgtc 24240tgccagaaat ttgacatgat aaatatacaa atctgtcatg
tctaccctgt gagggaggtg 24300gcctcagaat gatacagtgc acagcttgca cagccatata
tgactgtcct gaattgggac 24360accagtttct actgaaagta gaggtgacgg aggaggctgt
cataaaacat gaaagattgg 24420ttgaaactat ttaaggagca gttagagctt tagcttccct
gtctcacctt agtagaagac 24480tggaagttta ttctcttgaa cgtcaggcag agttgagggc
aggagacctg tactagcaag 24540aggattaaat caaagtatac cctctgaaat gctgaatcac
cctcctgctt cttccacttg 24600gccccaggga cactgtattc aggcctttac cctccaggca
gaagaatgaa agacatttct 24660taggggaata tgtccagctc aagaggtaag acccaaagat
tttcacaatg gggttcccca 24720gctaaacatc tcagtggatc accctgcagt gacattcata
gtcaataagt actacgcacg 24780tattggagct tcaaatcacc tttaaaatct cccattcttt
tcttttttct ttttgagaca 24840gagtctcgct ctgtcaccca ggctggagtg cagtggtgcg
atctcggctc actgcaagct 24900ctgcctcccg ggttcacgcc attctcctgc ctcagcctcc
tgagtaactg ggactacagg 24960cacctgccac cacgcctggc taattttttg catatttagt
agagacagag tttcaccatg 25020ttagccagga tggtctcgat ctcctgacct cgtgatccac
ccaccttggc ctcccaaagt 25080gctgggatta caggcgtgag ccaccgctcc cagcccaaat
ctcccactct taaacttaag 25140caaccaagga ttaccagtca tttgaggaaa gattctaaca
tgaaagatag agacccaaaa 25200caaacaaata tttaaaaagg aagttagaga aaactgagaa
tatacagaaa gaagaacatt 25260gaaaaatgcc attaataaca tcagagaatg aaaagattac
attgattaaa caagaacagg 25320atagtataaa aagaccttca cagaataaca ataacaaaaa
ctcttagaaa ttaaaaaaaa 25380gatagtagaa ataaaaactg aatagagagt aaagaaatag
ttcagaaagg gagagcatgt 25440agagattgaa gtaagaacaa agataagaaa atgagaggat
ccacgccggg cgcagtggct 25500cacgcctgta atcccagcac tttgggattt aatataaata
tattaaatat tttaaataat 25560ataattttaa ataatataaa tatattaaat atattaaata
tttaaatata ttaaatattt 25620aaatatatta aattcattca gtcaacaaat atttattgaa
tacctactaa gttctagtca 25680tcatgctagg cactgactgt tcaagaataa acatagacaa
gacttctgcc ctttcagaaa 25740ccagccaaga ttcttcaacc caaggcagct gtgaagtata
acacatctct ggctcaattt 25800tctccatatg gtttggggtt ccatgaatga gtctgtggga
agatttcctg tacgtagaat 25860gcatgcataa aggaataatt attctatggt tcgaaagaga
aaaaaagtaa gatcaaagtg 25920tagaagctat gttaagaaag attccagttt aatgattttt
gaaagagcag taaaaataag 25980accaagatgt ggaagctgta ttgagaaaga tccaatttaa
ttctaataat ctttaacaga 26040attgcccaaa gatagaatga attgttttga gagatggtac
agttagctgt cagtgggagt 26100gttcaatact aagcaagatt cactcgctca accattgagt
gatgaccaca tgcaggcact 26160gtgctaggct ctctgtattt tcagtaagct attgttgtac
aacaaagcac cttaaaacag 26220tgtcttagaa caacagtaaa tgtttatgat ctctcacaaa
gtctgtgggt cagcagcttg 26280gctgtgtgtt tctggttcag agtctgtcat gaggttgcat
ctgaaggctt ggctgaggct 26340ggaggatctg tttccaaggt gaatcacttt acatggctgg
caagttggtg ctagctgttc 26400ggaaggggct tcagttcccc cctgtgttga cctcttcaca
gggctgcttg cacgtcctcc 26460caacatggca gctatcttcc ctcagaatga gtgatccaag
agaaatcaag gtaggtgcca 26520caatgccctt tatgacttag acttagaagt gaaataccat
gacatagcct attgatcaca 26580catcagccac cattgtgagg gctagctacc acatcctgca
aatacaatga tgaacaaaca 26640aatggtgtgc ctgagc
266566263744DNAMus
musculusmisc_feature(750)..(850)gap of unknown length 6atatcgatca
gctatgacct gattactaat tatggccact gtgctctaaa gagtagaaat 60aaggtgccca
gccgaggtaa gagtcccctc agagaaagac tcttgggaga gtttgctgga 120atttaagtgt
gcaggggtgt tagcttggtt ctgctagtat tctgtgcgcc taagcaaaac 180aaaacaaaac
aaccctaaac agaccctagg accatttggg gggagaggtg aagcatgtgg 240aaaggcgatt
ggtgggtgag aagtcaccta caaaatagac agcagtcgac aggtggcacc 300caggacactc
ctggtcacac cacggggtcc tagagtccag atttgcccgg ctgtcatcag 360aaagtcgcag
tggaaaccgt cagcagtact aaggaaatgt gtaaactgtg gggctgagag 420tcagagcctc
cagcccgtcc tcctctgtcc tgactgcgag atctagactc tattctcatc 480gtcctcttgt
gtgatagaag ggcaatggac actggccctc tgcagcatct tgtgacgatc 540cgagcatttg
tgttcgtaca gactgcctct gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 600gtgtgtgtgt
gtgtgtgtgt gtgtgacaca gagagagaca catataccga gatagagaca 660gacacagaga
ccacttgata actaagtatg ctgtatactg tacatggtgc tgcgtacatt 720tttatctcaa
ggattatagt ttacctgagn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 780nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 840nnnnnnnnnn
gtgagtatca gctatgacct gattacgaat tatggccact gtgctctaaa 900gggatacaca
tctttaatcc tgcactcggg aggcagacgc aagtggatct ctagagcttg 960aggcctgcct
ggtctacaag tgagttcctg gtcagccagg gatacatgaa attctgtctc 1020aaaaaaaacc
aaaataataa attaattaaa aataaataaa atttatttat tgtatgtatt 1080tgatttattt
atttatttac ttacttactt acttattttt gtgacgggct tgcagccttg 1140gctgtgggga
aagtggaaat aaacctggtg gaggaacaag tgggaaggag agtgaagaga 1200cataggcttc
atcctggcac accatgagac aactcacagg accagagggc agagtggtgg 1260ctccttcccc
tggccttcac agaaatcttc ctggatgaca ggcacctgcc ctacaggctc 1320atgatcagat
gggacagatt cagctaaaca acacatgttg cacccagatt tgtccctgga 1380tacataaacg
taccctaatt ggctgaaaaa ctgcatatca gcatatgtac taaacagtaa 1440agttagagct
ggacctcgat gctggtcttc agatccaaat cccagggaat tttggggact 1500cggcttcact
ccccacccta tttcccgccc ctgttccaca cttgggtgtc ctgaagtaac 1560tctgtaggca
agttgactta aagnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1620nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1680nnntaactat
tcgacaacta ctatgacctg attacgaatt atggccactg tgctctaaag 1740ggaatcacag
tagtcctcct gcctcagcct cccaaacact ggaattataa gtgggtacca 1800ctaccacatt
gacttaagca atgaacctca gagctgtatg tgctaaaagg gttacggtgt 1860gtggattttt
aaatctcggt ttacaaagag aaaccgagca ggagcagcca ctccagtggc 1920ttgagcagag
gctaatccat gggtagggct gactcgcgag cctgggtgct ttgctcctgc 1980ctcactgatg
attcctgacc tttcttctca tgtcttctgg aacacaatcg cccttctggg 2040acatggagcc
gccttccttc cccaagaaac aattcatcgt tgttctgcta gcatcccaag 2100acatttgaca
agcggcagca actgggctga aagctgagtc taggatgagg tagntatttt 2160aaagaccctg
tgtttgttaa cttgcctttt ctccctccgc ccgtctgccc cccccccccc 2220tcttctctgt
ctctctctgc ctctgtctct atctttctcc cccaccccct caaggtttca 2280cgtagcccac
gctttcttca aactccctaa atagtacacg aatcctcctg cctctgcctg 2340ccaagtgctg
taattacnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2400nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnncta 2460ttgataatac
agctatgacc tgattacgaa ttatggccac tgtgctctaa agggctgcag 2520agatggctca
gtggttaaga acactgactg ctcttacaga agtactgagt tcaattccta 2580gcaaccactt
ggtggctcac aaccatctgt aatgggatct gatgccctct tctagtgtgt 2640gtctgaagac
ggctgcagta tactcatata aaaataaata gatagataat aaatctttaa 2700aaacaaacaa
acaaaagaaa tcaaagtcat aacagaaaga gaccactaag ggctagagag 2760atggctcatt
caggaaatgc ttgcgatgca agcaagggga cctgagttta agattcccca 2820aagctaaatg
taatgacaaa tgtttctaaa tccggtgctg gggagaagga ggcgggtgtg 2880gaagtgtgct
ggccaggcat ccccgattaa tcagggggta acaggctcca gtaagagacc 2940ctgtgttcat
aggtagctag aaggataaca cttaaacaat tcccagtgaa atccgttggc 3000ttacatatac
acacagatac atgcccactt gtacacacat gaacatacac acgtgtggtg 3060gcacacacaa
aagaaattgg tacacttgat acagcagtta cacccaacac agcagaagcc 3120atatgggtgg
agcctatggt catttatttt ctcactccta agctacttca ctttaatttg 3180gttagtgtct
ttttctaccc cgacagcnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3240nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3300nnnnnnngta
ttgacgagca tgttgacctg attacgaatt atggccactg tgctctaaag 3360aaatgttggt
ccctttgaag gaatgctttc tgatcagtgc tttatttgtt tgttagtttt 3420ttttaataac
ttctgactca cgagagctct ttccagaggt gtcgtctgag ggactctgct 3480gtaggccatc
aggctggggg cagagacggc ttcgtggatc taactccttc agtgcctctc 3540agcacatcct
ctacttgacc ttcttttcca cttgtacatg aacgcaggcc ctttgagaag 3600acactgggat
ctacctgtgt gcattaaggg ctgcctttct ctctaatggc tggagctaga 3660tagagtcgaa
ggcaacttgt gagcaacaat caaactctgg gagcagaagt gcaatgaaaa 3720gaaatgggaa
gatggcctga catcacctca gcccaactgg cagaaaacca gtcttatgta 3780tgacccaagc
caagagtgat gtgcttctcc aaacagaagg gagactccac ttcaactaca 3840ctcttcagga
cacagactcc ccaacaggta acaggataga tgattaatat taatgagatg 3900acacatctca
ttaatctact cttcccggga agacagccac ctctccagat gccagtacta 3960aaaagacctc
gatgtatgtt cagattggaa tctggctcta cctcacccag cctgtgtcga 4020catgaagagg
gcatgggaaa gtcnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4080nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4140nnnatatagt
agaacacctc tatgacctga ttacgaatta tggccactgt gctctaaagc 4200tggtaaatct
ggcatcatct acctgcctat tatcattttc ttgtggtctg catcttgtgg 4260tccagtaact
gggagtgctt ttgttgtttg ggggtcctgt tgctttggct gaacactggg 4320tgttctagat
gacagactgg ggtacctgag gtttctgata tacctcccac ctcaaagctt 4380ctgtctgctt
tgttcctttt caacacttgg attgactcca tccatattct taggatttgg 4440gtcctctctt
ctgggcaaaa cagcctggca aattctggga tctccctagt ttgaactgaa 4500gtctctacac
ctcttttctt agccaaacac agccattcaa ctccattaat tcttagctga 4560ttgcccactg
tgttgttcgt ggatgcgagt tgttttacaa acaatatagc aaatgttggt 4620ccctttgaag
gaatgctttc tgatcagtgc tttatttgtt tgatagtttt ttttaataac 4680ttctgactca
agagagctct ttccagaggt gtcgtctgag ggactctgct gtaggccatc 4740aggctggggc
agagactgct tcgggatcta actccttagt gcctctcaca catactctac 4800ttgacttcnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4860nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnta gattcgtcga 4920ngaacatcta
tgacctgatt acgaattatg gccactgtgc tctaaaggct cccatcatgt 4980ggttgctggg
agttgaactc atgacctctg gaagagcaga caatgctctg agctgctgag 5040ccactctagc
ctccaattac agtatatttt gataaatgtc atagtagtaa gacaaggttc 5100agaaagataa
aaaccccgga aaatatctga atttgccttt tcttgaatat gcacgtgtgt 5160aggccagaga
acaatcttga ccatcaccct caggatcatc ggcttagcac tcgatcaggc 5220tagactgcca
gcaactccag cactcaggag actgggcgag atggttcttt agtttaaaat 5280cagcctgggt
tatagaaaga gactctgtct caaaacaata tattttgatt tttgaaaaca 5340tatatgtgtg
tgttctaagt tatagtataa agtatgtttt tttatcatgg ctgtagtaaa 5400aattcttgaa
tttcagtgct ttagacacat tagcagtaaa ctttatggca atgttaaact 5460gctgaaacat
ttttaaacta taaaatgata tcatcagatt tgtgcgtttg tatgcgtgta 5520cctggaggtt
tgcatgtgag gtgtattttt attattcgtg tctgccaagg tcacgcagaa 5580acatggagaa
gacaagggat ggaactcagc attcacagat ttgacaaagt ctaactttag 5640ctaagagaag
annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5700nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ntgtacggca 5760tcagctatga
cactgattac gaattatggc cactgtgctc taaagccttt aaaaatccaa 5820aattctgtta
tgcctctcta gccagttaga gacagacagc agcaatgtgc aatgacatta 5880tttctataat
aacaagtaca gatataaaag aatcctcagg aagctgtaga gaagccgaag 5940actcttcaag
ataatgtgac attatctgaa gtgcaggagg gcacaccgag acgtgggctg 6000gggacagcac
aacatggaga actagctcct ttatgtgctc aatcaaaaag ttccccaaca 6060tttggtctga
tacagattga ctcatcccta ctcacccgtc gcgtgggcgt gatcctgttc 6120caggccagag
atcgcacggc tgatgagtcc ttcaacagtg gtcagagctt gtggtaaatg 6180aaacatgaga
caagtgagtg ctgacgtgct atcacttgtc tgtgtgaccc tcaacacttt 6240ccctgaactc
tgcaggcctc cttctcctca tctataaagc tctaaactaa gcacaccgtg 6300gtctgtctca
ctactggact cttaagagat ttaattagac gggcagtggt ggtgcacgcc 6360tgtgatccca
gcacttggga ggcagaagca ggcagaattt cgagtgtgag gccagcctag 6420tctacaaagt
gagttccatg atagccaggg ctacataggg aaaccctana aaccacnaaa 6480cnaaacnann
acaaactaaa gagagagaga gataactatc tcnnnnnnnn nnnnnnnnnn 6540nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6600nnnnnnnnnn
nnnnnnnnnn nntctatccc tcttagncaa cagctatgat cctgattacg 6660aattatggcc
actgtgctct aaagagctag cagtcttatg tcatctccag gcttaaggtc 6720agatatgatc
accaaccccg tgcagctggt ttgcacagcc caggctgcct ggccccttta 6780aacaggcgga
aaggaaggag gcagattggg agggtggtcg gataagtctc aaccccactg 6840cagtgtagcg
gcttccattt cttatgaata aagtgggtag gacctgcccc tcccctgaag 6900gtttgttgta
gaaatgaaat ggtagtgtct aaaagcatga ggtgccgcat gcgcacaccc 6960cttgtaaaca
gtcctcactg tgatagctaa actaggtgac cttctagact ggaatggaga 7020cccagtgtcc
tcagaatccc aaaagggctg cttgctaagt tcctgccacc cccaaacact 7080cacttcaaag
agacccagtg tcacaaaaca agtcttgcac attatagagt aaaagactaa 7140tgttcagaga
gtgccagtgg ctgccccgga tcacgacaaa acacacttgc aggccagctt 7200tccattttcc
acgttgctgg caccggcaaa gcctctgccc agtgttggga agctctttcc 7260catatgcatt
ggcacagccg agcagctggg ctatggtctc tcttgaaatt caattagggg 7320ttctctttct
gtcaccaaga gccagaagtc tcattgttca cacacggcaa actttcctta 7380cccaaacctt
ggtttaatgt cctggtgtgn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7440nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7500nnnnnnnnnc
atcgatatga tcctgattac gaattatggc cactgtgctc taaagatccc 7560tactcacccg
tcgtgtgggc tgatcctgtt ccaggccaga gatcgcacgg ctgatgagtc 7620cttcaacagt
ggtcagagct tgtggtaaat gaaacatgag acaagtgagt gctgacgtgc 7680tatcacttgt
ctgtgtgacc ctcaacactt tccctgaact ctgcaggcct ccttctcctc 7740atctataaag
ctctaaacta agcacaccgt ggtctgtctc actactggac tcttaagaga 7800tttaattaga
cgggcagtgg tggtgcaggc ctttgatccc agcacttggg aggcagaggc 7860aggcagattt
ccgagtttga ggccagccta gtctacagag tgagttccag gacagccagg 7920gctacatagg
gaaaccctaa aaaccaacaa aacaaaacaa aacaaaacaa aagagagaga 7980gagattaact
ataacttttt actcacatta aaacatgaaa atccactata attaaatgac 8040caaacacaag
ccactaggcg tgacctggac caagctttga aagaaaatag gaaacatctc 8100agcttgtgaa
cagctcacac acctcacaca cctgatctta aaactcacct cccttctggc 8160tggaagcttg
gatctcnaaa tccacctcgg ggatcttgtg gtggcagagt ctgtctttac 8220cacttctctg
gtcatgtcct ggacagannn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8280nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8340nnnnnnntcg
tctggtanga acagcagtat cgaccatgat acgacttatg gccactgtgc 8400tctaaagtcc
catctcacca tcgaagtcac atgtatgact ggtcccatag cttgtctgca 8460aatgcgccat
gacactctat tacacttggg cctcagcttc ctagcagaac caaaataaaa 8520tcccacatcc
tggcatgtgc aaccggccct ggccattcct gtcaccgtca ctccgttctc 8580tctcccttct
tagccctggc catgctgacc ttctcctttt gactcgcctc ttctctctct 8640ggccttgcat
tatcttcctt cggcttagaa ggctttgact actctgctta aatcagccta 8700tcacatcaca
cagattgcat ctttcaaggt ccttattaag agttgtgtgt ctctcctcat 8760cagaatgata
ttgaaaggga cagtttcttc tgctgctgca tccccaggac ctcaaccagt 8820gactacacag
tcagcagctt atccatattt gctgacagag cctctgcaag tctctcctct 8880acaatgtccc
tcaagcctta cctcaaatgt tctatcttga gtaaagcatt tatgtctatg 8940tgagcactag
catgaagtct gaatcangaa agctattgag ggtctttttt tctttagtgt 9000cccaggcttc
tttatttaag ttgatagtga cagcgtaatc tacatgagca ctcaacntca 9060tcatcatcca
tcaccttgcg catctgatcc tcctcagcta atgannnnnn nnnnnnnnnn 9120nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9180nnnnnnnnnn
nnnnnnnnnn nnnntttttt attattagaa atcagcttga tcctgattac 9240gaattatggc
cactgtgctc taaaggtttc catcccttgt ttagagattg aaaacattta 9300aacaattgtt
agctgtgtac atgggtacac acgcgctatg gcatgtatgt ggagttatgg 9360catgtatgtg
gaggtgaggg acaactttca ggagttggct ttctcttccc tttctaaggc 9420tcaaactcag
gtcatggggg tttactctct gccacctctg accttgggcc gagactttaa 9480ggcctgtgat
caatcaggag cagatggcaa gcgcctctct tcactaacag aatcttgata 9540tttccacccc
actccctctt ccacaccagc actctccccc catgtgtttt cctgtctgtt 9600aaattctctt
tctccccttt tggatttttt tttttagacc tgaaaatgag gtttctccaa 9660atctaagctc
ccacccacgc ttttcaaagg tcttgtgggc tccacttccc ttctgtgccc 9720tcctgtctgc
tttcctgagt gatgttccca agcctcaagt cacaagaagc tatcacttga 9780ccagctcttc
tgagtgccca gctgaggctc acttctctgt caagtggaag tggctaaagt 9840gccacaagca
ccgcccgtgt gggaagactc agcttgattc tatcttcatt gctttctgta 9900gaagtggaag
gaacttgagc gaagtgccga tctttcttga cctgtgccct ctgcagccta 9960cccacaagct
ggtgatagan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10020nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt 10080ctttttcttt
tntttagcgc aacagttttg accatgatta cgaattatgg ccactgtgct 10140ctaaagagag
gtttgttctc tcatcctacc atttgggttc tagggtttta actgatgtca 10200tcaggctggg
tgactttgtt cactgagtca tcttggtggt ctttcaatgt tttctgagtt 10260caggctctgg
agtcgactcc ctgtgtttgc acgtggatcc cacacagtct gtgctgtgtg 10320gtcttggatg
agtcttcgtt gtgaagattc tgtgagatag tctggctccc cttaggttcc 10380tcgttgaata
ttagctatgt acgggttctc tctgtgtacc attgacccat tggtcctcat 10440cttgctttac
ctaatcatgc ctggtccagc ctgtgctgtg cccaaaggtc agaactgatg 10500ggggatgagt
cacgtaggac atctcagcta cagttccacc tcctgaacct gcagactgag 10560tctctcaagt
gccagcagcg tgggacaggt ccagaggtgc ttgcccactc ataccctctc 10620tgagaagacc
tgtgttacct aagtttgttc aagggtggtt tccagtgacg ggctgtcaga 10680tatgcataga
tatctgagtt gtccaggggt tcagaagttg gctctgagct aagagactgg 10740gtcatcgtac
acacatgtgt ggctagcact cacgtatgca ccagccccta cagggagttg 10800tattgcctcc
tgcgcgttat aatcatnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10860nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10920nnnnnncata
ataattagtt taacagtcgt accatgatac gaattatggc cactgtgctc 10980taaagaacaa
aaagaagaaa tggtggacaa ttttcggcag gagtcacgca gacgtcttat 11040cagctgccat
gtagaactga tgagaattga tctacagact gatcctgtga gcaagcagca 11100gtgaaagaaa
gaaaacagtt attcaagaac atctatgaaa attcagtaag caatgagggt 11160ctagattctt
gagccagccc tatgcatggc accacagcct ctctgactct cccatgccct 11220cctcatgtgc
acacaggctg ggtgaggtag agacagattc caatctggac atacatcgag 11280gtcttcttag
tactggcatc tggagaggtg gctgtcttcc cgggaagagt agattaatga 11340gatttgtcat
ctcattaata tttatcatct ttcctgttac ctgttgggga ggctgtgtcc 11400tgaagagtgt
agttgaagtg gagtctccct tctgtttgga gaagcacatc actcttggct 11460tgggtcatac
ataagactgg gtttctgcca ggtgggctga agtgatgtca gggcatcttc 11520ccatctcttt
tcattgcact tctgctcccc acatttggat gttgctcaca agttgccttc 11580gactctatct
agctccagcc attatagaga aaacagacct tatgcacaca ggagatccag 11640tgcttctcaa
gggctgcgtc atgtctagtg gaaagaacgt cagtataaga tagcatgaga 11700nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 11760nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ttgctgcggt ttttanagac 11820atcagtntng
accatgatta cgaattatgg ccactgtgct ctaaagttga tggttatatt 11880aagtgcttgg
caccatcaga ccttctgaat aactctggcc caaggttcct catttttcct 11940ttccaaaaca
ggttttgtta cctgctccaa atcacccagt agaagtatca ggaaactagg 12000atgcaaaccc
aggtctgggc ttatgacaca cagaggacgc cttggaaggg agggagaagg 12060ccagagcagc
tgggaccacc cacagcatgt tccagtccat cccacgggaa ctttacccat 12120tctgaggcag
aggggtttga cttgcagacc tgaggcagag gctacagcca gtatgtgaaa 12180tcttttggaa
ggaatccctg aactactcta ctctgagatt ccctccttag ggaggctcta 12240agtctccaag
ggcagggaaa attcattcca gagactgcag cctcctgtgg ctggctgtcc 12300ccataaaacc
actggggtcc tctgatgggt tcatttcttt gccccagcga ccaccagctt 12360tgtcatagac
aggcaagcca cccatcaaga ggctcctggg caaagcctgt tccaccttgg 12420ctgccaaggc
tcgttcatat cccgtggcat ctattataca gctctggagt caacagattt 12480atccataggt
ggagaaaact ccggcgcaaa catgagtact ttacagtggg acagagtggc 12540ttacttttgt
atagataaga caaannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 12600nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 12660nnnngatttg
agacagcagc ttcgacctga ttacgaatta tggccactgt gctctaaagt 12720gggaattgaa
ctcaggacct ctggaagagc agctagtggt cttaaaccgc tgagccatct 12780ctccagcccc
agttgccaat gtttttgtta tgtgtagatg ctgttattca gcctcccttc 12840cagagaaaac
ctcaccatat accatgacca ctaaaagggg tcatgtagtt cagtgacgat 12900atgtcttccc
agagtggtga gggcctatgc tcacttgcca ggatgggaga gctgggtagc 12960tgtgtagagt
gggctgagta cggtggccag tttttgcact tggaaggtca gagggttgag 13020agttcaaaac
cacagccttg cccatatagc aagtttgaag tcagcctggg ctatatgaga 13080atatctaaaa
acaaaacaaa acaaaacaaa acaaacaaac aaacaaaaac cacagatcat 13140ctctaaaatc
ccattatgga aagtgagttt tcaagctaag aggaactttt gagaccatct 13200atttgaggtt
ctaccatgaa cttccttcta gataagggcc tgttgagagt ggaaggaatt 13260tgctgtgtcc
tttatctctc agccttagat gcaaggatgg accttgcgcc caggtctctg 13320catttgngac
tccaggcagg aatgtactct gcccatctcc cttagaaact ccccaactcc 13380ctaaaaccag
cttggaatct gtctaccaga tcagggagtg ggctggatta caagctggtn 13440nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 13500nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt gttgttgctt tttntagcta 13560cagctttgac
ctgattacga attatggcca ctgtgctcta aagggcgcca taggtctgta 13620accctgtaag
tactggctct tctcaggctg tcacagtggc catggtggga caagtaaggc 13680cagcccaggc
tctagccagt cctggacact gtccctctgg ccagctggct agtgcagaag 13740gcgctgggga
gttaagtaaa ggcagggccc gcagtggaca gacaagcagt gttcattggc 13800tggccagtca
ttcagtaagt ggggcggttg ctggtcacag gatttggggg gtgggttctg 13860cccacactta
gtaaaggctc gagggagcca cttgtctact ggggcagccc ccctgaggct 13920ggggagctta
ctaaccccaa cagtgccagg agaaggggaa aaggtgagtg tgctagtaac 13980cagctggggt
catccttctt tgaccctcca cgtggtgttt gctcagagga attgttgtca 14040gactccctgg
cgcctagagt ataaagtaag agtggctgct ctctgtgccc agaaccggac 14100aggtgagctt
acatggcaca gggatggtgg ggngtgggtg gcagaaaagg taggagagag 14160ctgcagatca
agctagcaga aattgtgtgt accagtcctc attcctaaaa gcngctcggc 14220agacagaaga
caggcgaacc gaggagctag attgcatttg agtggtgggt catctctcta 14280ggcagtctga
gtnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 14340nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntacatcat 14400cgcttgacct
gattacgaat tatggccact gtgctctaaa ggctgatcag ccccacctcg 14460ctctcttact
gcttactctc ttacttgtct ccctcttacc cctcactctc accttctctc 14520ccctctcttt
gtcttctctc ctctcttctc tctctttgnt ttctcctctc ttctcctctc 14580ctctcttctc
tccctcttac tctctttctc tctagtctct ctctctctct tctctctttc 14640tccctgcatt
tctataataa agctcttaaa ccatagagag tctctgctca tcaaggctgc 14700atgcactctc
gtaggtattg ggaacatctt ccctcatccc tctctcctat aaccctggtg 14760gctttagcaa
agtagctcca gggtccccag gtagggctgc ccctggccgt cccctgaaga 14820gagggtcaga
ggcttggatg cccatccagg gatgagtgga aaggtagcag ccctcccaca 14880cctgacaaac
cagagaatan gtaaaactct ggtggggcat gggtctatct cccccctctt 14940cattccccag
gccccctttt ttagctccca cacaatactg acttccaggc agctaggatg 15000aaagtcttag
agcccatgct cacagtgata catctattcc acaaagccac acctcaaata 15060gtgcacttcc
tgggccaaca tatcaaacca tggcactgag atggtcttct ctgcccacnn 15120nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 15180nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnntt gccgtggttg nnngacatct 15240ataagccatc
attacgaatt atggccactg tgctctaaag tttattattc cactgcactg 15300taacttcgtc
tcagtgggga actgttgtac atgggggaac tgttgcttct ggctcacaaa 15360ggtatctgcc
atcacattta catcttacat cacacgggca cataacacat aattaaaaag 15420aaattccttt
aaaaatccaa aattctgtta tgcctctcta gccagttaga gacagacagc 15480agcaatgtgc
aatgacatta tttctataat aacaagtaca gatataaaag aatcctcagg 15540aagctgtaga
gaagccgaag actcttcaag ataatgtgac attatctgaa gtgcaggagg 15600gcacaccgag
acgtgggctg gggacagcac aacatggaga actagctcct ttatgtgctc 15660aatcaaaaag
tttcccaaca atttggtctg atacagaatt gactcattcc tactcacccg 15720tcgtgtgggc
tgatcctgtt tcagccagag atccgcacgg ctgatgagtc cttcaacagt 15780ggtcagagct
tgtggtaaat gaaacatgag acaagtgagt gctgacgtgc tatcacttgt 15840ctgtgtgacc
ctaacactgt ccctgaactc tgcacgcctc cttctcctca tctataaagc 15900tctaaactaa
gcacaccgng gnctgtctca ctactggact cttaagagaa taaattagac 15960tnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 16020nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn natatacgat atgatcctga 16080ttacgaatta
tggccactgt gctctaaaga ccctacggag ggcagtagat attgaagaaa 16140gctattctgc
tttaagctag aacacctcag tgtggttgac atgaagggta tggagagtta 16200ctgcccgggt
cctggcactg tactgctccc cctgcccctc cagagattac ctgctgcaac 16260tgcttgatgc
tgctgctgtt gcccattttt tccaggtgag ctttgaaggc ctggatgctt 16320gcagccccgt
ctgagaaccg gcgcacgggg gagaaacgct ccgtagggag atgcacggtg 16380ttggagtcct
tgtaggtgga gctgaatata tgggaagaga cggttagcag ccaggactcg 16440gggggttatg
accaatcaca cgggaccatg ggtctacatg aatacagaga cagtggatgc 16500atgaggagcc
ctgcacatgg tactccgtgt cacttcctgg agtggctgtc cccctgagtg 16560gactacaggc
cctcatctcc cacctccact tacactcagt tggtcctact tcctcagcct 16620gctgcagtcc
tggggtcaac tacatccggg tcttatataa acatactaga gcagggtgcg 16680aagtccgcag
acggccagga ctggctgaac cacacaggct tggctcttat agtcacatca 16740tttatttcta
ttgtagntgc atttggggag cggtgtgtgg ataatgttgt gcaagctatg 16800ggttctaann
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 16860nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt tgtggtattt 16920gcgatcagta
tgacctgatt acgaattatg gccactgtgc tctaaagtca agacgggaat 16980tacagatagg
tgctaggaat tgaacccagg tcctctggaa gagcagctcc tgagccatct 17040ttccagtcat
ggtctttatt attctttaca tcttttacca gtgcacactt gaatcatatg 17100ttggtcattt
gtaacttaca ggttggctga gttttacaca ccttccaaat gctgacgttt 17160ttattataca
ccatcagaaa attacttgag tggtagattg agaaagttct ctaaatacat 17220gtagaatatt
ttcccattct tttgattctc cctagtgact gatgccctta atatacattc 17280agcaattact
tgggatgatg gtgctttata aaactctgtt aggctaaggt ggcttgagag 17340tttacagaac
tgtcctgata ccttagttgt tttctctcag ttgctgttat gtctcagctg 17400cgttgggtcc
agaattccca tctgatggct tgcatgtctg cactgagatt tcccatctgc 17460tcacccattt
aaagactgtt ttctcatttt gtaaaaatat ttataaatgg tgttttgaag 17520gtttgtctgc
tgattacaac attctgctca ccacaaactt gctttttggt aataacctgt 17580cccctgcctc
cctctctgtg aggaccgaca gggtctcact ctgtatgtca gtctgattta 17640gagcttgcta
tgtagcccan actgatcaca gactcagcac nnnnnnnnnn nnnnnnnnnn 17700nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 17760nnnnnnnnnn
nnnnnnnnnn tgtgtttggc tttgcaaact gctatgacct gattacgaat 17820tatggccact
gtgctctaaa gttctcgcca agtgtcttca ggtgggtttt ggccctggtg 17880tggtactcgt
tcaactangg ttgctcttga gctcagccag gcgctgggcc aggctctcgc 17940gcatctgttc
gctgtggggc gctagctgtg tgcgcagaga gtctacgtgt gtgcgcatgc 18000ggtcgcgaaa
ttcctcagcc acaggggaca gtctcccttg cagctcctgc agcttctggc 18060gcgcgctctc
ctgcagctcg gcgcccagag gcgccacctt ctggcggtag agctccacat 18120cctctttcca
tttcttctgg aattcgtcca ggtagggctg caccttctgt ttcacttcct 18180ctnagtcctt
gttcatctcc tgtctcaccc aatctgtttc tttctccagg ttatcccaga 18240agtcccgagt
caatgggccc agccgttcct gcagctgact aacggttgaa cccagagtgt 18300cccagttttc
caggagattc acgctagagg gggaagagag cggctgagag acgagcccag 18360gcatcatgcg
ctgcccctgg tctgcagatc catgcacatg atagctgngt gccacctgtc 18420ccctaatgtg
caggggctat ggggctaggt tccccgaaca tgcgacccgt ctaactcact 18480ggcttctctt
tacatttntc tgtgacacat gcggggaggg agccagnnnn nnnnnnnnnn 18540nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 18600nnnnnnnnnn
nnnnnnnnnn nnnnnnatta aagttatcat ctatgacact gattacgaat 18660tatggccact
gtgctctaaa gaaatccaag taggccctca ctccctcttc gctctctcag 18720aatgcgtttt
tgagtttgct ggcaggcaca ttggcctgtg cattgtctga aagactcagg 18780gcagcgtgga
gtgtgagcca cgtttgtggg tgacatgtct gagtcacagc gctttctgcc 18840ccttcccagg
aatagcccta atgcctttcg tagctcacga tgctgccgtt cccccctttt 18900gtgttttagg
attctatttg tcctcctcag ccctccccac ctcttcaggt tgcctgtgaa 18960aaccaaccag
ccctcctcac ccaccagctc cagaggtaat gaactactta gcctcttcct 19020gcattgttgg
ctggctggac ggtgtggctc ccttgtctga cgcatgggga cgcttgactg 19080acttgagcat
ttgggatagt cttctagaag aacagggaag ccgagttaga gtttgaaggg 19140cttactagaa
tgctgactat ttcctgagct ccatgaacac agtggcctga catccatcga 19200aggccaggcc
agtgagtgct gagttggtgg caggggaagg actggtagac tgaggtgtgg 19260gcaagctgtg
gtggcctgct accgcagttg tccgcccana ctacanactg tctgtctgca 19320tggattgtct
gggctgatgt tactgcagat gttctgtcac tcagaagcnn nnnnnnnnnn 19380nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 19440nnnnnnnnnn
nnnnnnnnnn nnnnnnnnct atcaacaatc cgctntgaca ctgattacga 19500attatggcca
ctgtgctcta aagatttatt tttatatgag tatactgcag ccgtcttcag 19560acacacacta
gaagagggca tcagatccca ttacagatgg ttgtgagcca ccaagtggtt 19620gctaggaatt
gaactcagta cctctggaag agcagtcagt gttcttaacc actgagccat 19680ctctgcagcc
cacgactttg atttcttagg taaaaatctt tatgacattt atcacctctg 19740gttgagtctg
taggccataa atcttttcct atcctctgaa aagggactgc tggctgtctc 19800catctattat
tcaaggcgat gctttaagct ggacatccag tgctcacctg taatctcaac 19860atttgggagc
ccgaggcaga agaattgaaa attctccaac ctggtctcaa tctcccaccc 19920caaaagtaat
attttaccat ctgtatattt gaaagagcat agtgaattgt aggttcatgt 19980atgcttaccc
ttggaagtgt aaatgaaaga tttctaaaca ttgcagatat aaccttgcct 20040ctaagatact
ggtcattctg aaatcatttc ttcccggggc ttgttttctg tatacagtca 20100gcatatctac
aattatgctt ttccctgtat gtcacctcaa gtatccgatc caagatgctc 20160tgntaaatca
ccgtgtgcca tgtttgcatg caagcaatgt acaagtacag gtgnnnnnnn 20220nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 20280nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnttatcat caatatgacc tgattacgaa 20340ttatggccac
tgtgctctaa agatctagcc ctatcagctc taccagcccc ccagaccccc 20400cactagactg
aggacagctg tttgtctgtt gcagagtgtg agcacttgat ccgccacatg 20460ctggtgttag
atccaaataa gcgcctctca atggaacaga tctgcaggca caagtggatg 20520aagctcggag
atgcagaccc caactttgac agggtaagcc ggacccttgc ctcagggaac 20580tcctgattaa
ctccttctct tcttcagtgg ttgtgatctg cctaggacct aaagagatga 20640gcagtaggaa
ccagctgctg gctaagacca gtggcaggtg aattcacagg gagccgcggg 20700atccagcaag
gctgtggaga cagtgatact gggcattacc acagaaatca tagtttgctt 20760ttgacttctg
agacagcata ctcccagttc tgcaggtcac tgccaccaga gtgcctttct 20820tgtcttgagt
gcgctccctt caacagcttc tgtcacatac tgctgcaccc cattatgatc 20880actctcgtac
ccccacgagc tcacgaagca gcccctgacg gttttggtca gcccatagct 20940gattgccaga
actgtcttgc ttagacttcg tatgacaccc acagaatctg cagcagtggg 21000gccatacaac
agctttggca atgtgtatnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 21060nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 21120nnnnnnnncc
cttcgtcagc atcatctatg acctgattac gaattatggc cactgtgctc 21180taaaggaaga
tgatgtcctc tgttgctgtc taggctgtgg gtctcagtac tagctcaggg 21240gactatctta
gttgccccag agcgcctcct tcatcctcac cttctttgtg aatgccctgt 21300ctataccttg
ctgcttgcag gttctcatag atagggctca tgtaggggtc agatatcacc 21360cagccatggg
ccctgctcct atctcaggat tactaacgat aggtccagag ggcaagagga 21420ggcctgtgga
ggagttgggg aggggcaagg ccttgggttc catgtgacct ttgtccttct 21480ctcactaatc
cctgcccagc tactgcagag gagactgttg ggatcacagg tggaggtcag 21540tgtgggggca
tgtaaccttc actctgcccc ctcccacccc acttcctccg atgctccaca 21600gtggcaccac
agattcccca ttccattcta ctggaaggct ttcaggcggc ttctgtgaca 21660gagcctgtca
ctggctctag gctgtaaagc aggcctgagt ccaagcttgt ccctgtcttt 21720ttctgtctca
ccgactcatc tagtgagccg gtagctcacc cttggcggcg gcagtggacg 21780agaaaagcat
gggcaatctc agaaggattt ctcaactcct ctggcagatg gctgcatgga 21840cgttctgcct
caggctctga tctggacgnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 21900nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 21960nnnnnnnnct
tgattttggg atcatcttcg acatgattac gaattatggc cactgtgctc 22020taaagagtcg
agctgaggtc tgaaccccga agtcataatt caccttcatg acacggnagg 22080cattccctta
tgctcctgga actctggccc ctgcgtaagc cccccacatg cccccataag 22140agaagcatgg
tcagtagtca cgtaggcaat ggtccaagct tctgaccttc aggctgaact 22200cctccccagt
tacctagcaa cagtaaagac cataaaaagg gctgatcagc cccacctcgc 22260tctcttactg
cttactctct tacttgtctc cctcttaccc ctcactctca ccttctctcc 22320cctctctttg
tcttctctcc tctcttctct ctctttggtt tctcctctct tctcctctcc 22380tctcttctct
ccctcttact ctctttctct ctaggctctc tctctctctt ctctctttct 22440ccctgcattt
ctataataaa gctcttaaac catagagagt ctctgctcat caaagctgca 22500tgcactctcg
taagtattgg gaacatcttc cctcattcct ctctcctata accctggtgg 22560cctttatcaa
agtagcttca gggtccccaa gttaggcgtg ccctgggcgt gctctgaaga 22620gaggtcacaa
gctggatgtc ctnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 22680nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 22740nntggtataa
gagatcagta tgacctgatt acatattatg gccactgtgc tctaaagatc 22800cagtaaaaaa
cgccctgttc ctaagccagt gtaagaggca aagaaaggag ggcccttggg 22860cctggctggc
cagtctgtct agtttaattg gtgggttcca cgccaatgag agatgctgtc 22920tcaaaggagg
tggacaagtt ctctgaggtg acaccaagac tgtcctccag cctgacacac 22980aggaaagcag
caggcttgct tgcacagcgc ctgcctgccc ttcatggtgg ccagccttcc 23040ttcctcttcc
tgctcactct agtgaagacc ccagggtagt gaggagaagc tggagaggaa 23100acaaggaacc
agcagacagc tgggggtgct ggccacacac tccccaaccc tggcagcaca 23160agccccatca
ttgggtgcta attaaatccc cctaatgagg aaaacggatg caggagctgg 23220ctcctccggg
gcctccccgg ccccacgccc ttgcctctcc atcggactta tcgctcgtca 23280caggatgttt
acaataattt ttaatttgtg caattattaa tcacttttct atctccctca 23340tttgcataat
aattagacat ctcactgttt gggatgcctg ggaatgacag ggtttaaatt 23400gaatttagat
ttaatattct attttctgct ttttcccttc acacgctata aagccagatt 23460ggcaccagag
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 23520nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ttatctatac 23580gcattacact
gattacgaat tatggccact gtgctctaaa gtactgctgt gaacagatac 23640catgaccaag
acaactctta taaggacaac atttaagtgg ggctggctta caggttcaga 23700ggttcagtcc
attatcatca aggtgagaac atgacagcat ccaggcaggc atggtgcagg 23760aggagctgag
agttcaacat ctacaattta aggctgctag cagaatactg tggggaattg 23820caggcttgtc
tccagtcgag ctgaggtctg aaccccgaag tcataattca ccttcatgac 23880acggtaggca
ttcccttatg ctcctggaac tctggcccct gcgtaagccc cccacatgcc 23940cccataagag
aagcatggtc agtagtcacg taggcaatgg tccaagctta tggagccgtg 24000tagtcccagc
ccctacaagt caggccagga gggtcagtgc agccttgcag ctaacctggt 24060ctacattgta
agtcccagtc taaccacagc tacaaggcaa gacacagcct taaaaaacca 24120gcatgccaga
ttgaatgcca aagtgaatga aatggctgat gggtggcaga ggctcttcat 24180gggcaaggtt
ggcattggtt ggcaaggatc agcatcagca ttgtggatag tggggtgctt 24240cctctgtcca
ctggactcgt tgctgccaag gtcactaaca agctcttgtt ngataaatca 24300gtaggcattt
nttatcntta tttttntgga tggctcannn nnnnnnnnnn nnnnnnnnnn 24360nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 24420nnnnnnnnnn
nnnnnnnccc cttttttgat cactacgacc tgactacgac ttatggccac 24480tgcgctctaa
agagtggggg ccaatcttgt ctcactaaaa ttttgacttg ggcggcagag 24540actcactggc
tgcaccacgc acaaagacaa ctagaggaag atctgcactt tggttctgca 24600aaccacatca
ttcagaaaac acaggatgac tctgttctca atgtgagcaa tcagagactt 24660tctacatcca
gtttgaaaag actggtttga gatggtggct catcccggat tggacctgca 24720tgtagaacct
cctgcaagac tcacctcaca cttcctaagg agacctttgt tggcagctcc 24780cagaatctgc
aatgagcatc catttctcct tcagcctttg aaatcacaca taaagataag 24840gttatgcaga
taatctgaat atttctggga atattgaaga atcctatagt cggttataaa 24900gggatattgg
aatctggaag aaaacgggtg attccgaaag gtctgaactc tgccattatg 24960cgtggagaag
aacagaactg aagaactgcc aacagggtta gtctcctgcc tcatttaaga 25020acgttgtgga
gaatcttcat ctgtaaagac aactttctct cctgatcctc acgccttctt 25080gcctcaagtt
gatgttgatt atccgcacgt taannnnnnn nnnnnnnnnn nnnnnnnnnn 25140nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 25200nnnnnnnnnn
nnnnntttga atacggatgg ccagctccat gtgctctcag gtgtgtatgt 25260gtgtgtgtgt
gtgtatgtgt gtgtgtatgt gtgtgtatgt gtgtgtgcgc gtgtatgtat 25320gtgtgtatgt
gtgtgtgtgt atgtgtgtgt ctgtgcgtgc gtgtgtgtag tgtgtgcgtc 25380gtatgcgtgc
gtgtaccgcg tgtgtgtgta ctatgtgtgt catgcccgcg tgcgcccccg 25440tgtgcccgcc
cgccgccccc cccatccccc atccccatcc cctgcctata cccggccatc 25500cccccacccc
ctctccacac cccagtctcc ctcctcccac ccccaccccc cgacccatac 25560cccacccccc
ccaccctccc cacccaactc cccctccccc ccttaccccc tcccactccc 25620cctctttttc
cccccaccac actaacaccc ccctgccccc ccccctgacc tccccccctc 25680cctccccccc
accccccgct ccccgcctat tttcccctct accccccccc cccgtcccca 25740cctcgatccc
cccccccccc ttcccctggc gccacccccc ccaccccccc ccccttgaaa 25800cccccacgta
cccccccccc tcccccccat cccctcccca ccccccctcc ccaataacta 25860ccctcgcctc
cccccacctc tccacccctt cctccctacc cccaattgac ccccctttcc 25920ccccctcctc
ccctgcctca cgnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 25980nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 26040nnttagcaaa
catcttgaca ctgattacaa ttatggccac tgtgctctaa agaggcatgg 26100aggagggggc
attatgtggg tatgtaggtg ctcttgctaa ggacgtctta ngcccaaggt 26160gtcccctctg
ctgtgccatc ctctggctgt gcccggatga tatcagaaca gagggggtgg 26220agctatggcg
gaggaggaaa aggcagatgg ctcagatggg aaggcctggc tgctgtgtgt 26280tccttagatc
cagagaggcc actagcctca ctgttcacat ctccaggatt ctgtttggac 26340cactccatgc
aggagacgcc ctcaccccaa cccccgcctt catcccatat gtcttctcag 26400acttgggcca
tctcctccac cagttggccc aagcttttga atgccaatat gatttggggt 26460tttgttttgt
tttgtttttt gaaacatttt ttattctggg gggttttaga tgagaactat 26520ctggtaaaat
ttatatgagt gttcaaaata aaactaaacc ctgaaattgg aaatactgat 26580cccaagcatt
tccgatgaag gacagtctgt ctgcactgga gttcggtggc agaggcagcc 26640tagcaagaga
agctgctagc ttctagcagc acagctctac agcatggcca tagggagggt 26700gctgagcctc
agagaaagct tcgcagatgc ttggatggaa ggaagctgtc tgggtaggtc 26760tcagtactgt
ggttatgctg accttgctct agggaccgga gactgaaacn nnnnnnnnnn 26820nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 26880nnnnnnnnnn
nnnnnnnnnn nnnnnnnnna tggccactgt gctctaaagc agcccatgga 26940atgaccccag
cccatggaat gacctcagcc catggaagga ccccagccat ggaaggaccc 27000cagcccatgg
aaggacccca gcccatggaa ggaccccagc catggaagga ccccagccat 27060ggaaggaccc
cagcccatgg aaggacccca gcccatggaa tgactccagc ccatgggagg 27120accccagcca
tgggaggacc ccagccaatg gaaggacccc agcccatgga atgaccccag 27180cccatggaat
gaccccagcc catggaagga cctcaggcca tggagtgacc ccagcccatg 27240gaaggaatgg
tgttgcccac acttaggctg ggtcttccaa ctcccttaac ctaatgtaga 27300taatccctca
ctgatgtgac cagagatttg tttccatggt gattctaaag cccatcgagt 27360agacaatcaa
gattagccac cacagtctct gaggacaaga tgcctgcatg cagaagtgtc 27420tctccctatg
ccatctaaga tggctgccag ataactgtga acttaattat aatgtcatcc 27480ccacactaaa
cgacatactc cagtgtcttg acagttgaca attgctgtga tgacaactag 27540aaagaaccat
ccaaggagcc aaaggaggtg gccccagaat tcctgggaaa gctctatcca 27600ctcncagann
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 27660nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnng attatcatgt 27720tgacctgatt
acgaattatg gccctgtgct ctaaggggca ctccatcgct tctgcggggg 27780ggaataaagt
cgcttacctt tatcctcgnt gtgcctacgc ttacagttca aagacctgct 27840ataccaacct
cccctcggct ggtgcgatgc gtggttatgg cgcgccacaa gtcgtatttg 27900ccggtgagtc
tatgcttgat gacgccgcga cagcgttagg tattgatcct gttgaaattc 27960gtttacgcaa
cgccgcccgc gaaggagatg ctaatccgct cacgggcaaa cgtatttaca 28020gcgcagggtt
gccggagtgt cttgaaaaag gccggaaaat ctttgaatgg gaaaaacgcc 28080gtgcacaatg
ccagaaccag caaggcaatt tgcgccgcgg cgtttgcgtc gcctgtttta 28140gctacacctc
taacacctgg cctgtcggcg tacaaatagc aggcgcgcgc cttctgatga 28200atcaggatgg
aaccatcaac gtgcaaagcg gcgcgacgga aatcggtcag ggtgccgaca 28260ccgtcttctc
gcagaggtgg cgagatctgt gtgggtgccg gtcagcgacg ttcgcgttat 28320ttctactcta
gataccgacg atacgccgtt cgatccctgc gcattatgct cacgctagag 28380ctatgttgcc
gcgcctgcgc tgcgcactgc gcactatgat tcnnnnnnnn nnnnnnnnnn 28440nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 28500nnnnnnnnnn
nnnnnnnnnn nnaaattaat gtggagactc agcgccaacc tccatgngct 28560ctccagagga
agaggaactt atgagggtta gaagggggct ggggggctgt gatcaggata 28620taaaatgaat
acatacatta atgagaaaag tgatattata cttctaaagt gttgtaaatt 28680aatactggtt
cttttagaat acaggagttt aagtttgcca atctgccttt cacctctatt 28740tggccgtgtt
aattgctgtc agcacagaga attccgcgnn nnnnnnnnnn nnnnnnnnnn 28800nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 28860nnnnnnnnnn
nnnnnnnnct tcgtgccgct tctccctggt ttccgacacc ttggccggtt 28920tacccgggaa
acactggtcc cgcctttttc tccccttctg ggaaaacggt gtgggggctt 28980ttcttaataa
acttcaacgc ctggtgaagg tattcttaaa atttcggggg agtaaggggt 29040ggtttcggct
tttccaaact ttgggcttgt tggttcaaca caaacccccc cccggttcag 29100aacccgaccc
cggtgtggtc cctnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 29160nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 29220nnnntttggn
atcgtgactg gccaactcaa tgtgctctaa agccacaatc tccagcaacc 29280agcccaaagt
cgggcccata caagacattt aatatttgtt gaattcaccc ggaggccagc 29340ataagcttct
aaagcatgcg ggagtaattg aaactcatta gagtttcttt gggtcaaatc 29400aatgcataga
ggtattaaaa ggttatttgt atacattcaa accatacaca atccttatag 29460accactagtg
gcaagtctgg gagaggttca tggattatat gcacacacat acacacatgt 29520cctcgcacac
ataagtaaat gtagttttaa agttaaagga agatattata agatttaggc 29580ctaaattgaa
tctttgcaat gattggtttc tttttctttt tccttttttt tttttttttg 29640gggggggggg
ggggggggaa gcaagggttc tcaggataat tttggctggc ctggatctca 29700ctttattaac
caagctgact ttgaacttac cgagacctac cttgctctga gtgagtgtga 29760gctggcacct
tctggatgcc attggtttct tctttgggac ctcttaggac agacctggtc 29820cttgacaaga
actttgcagg ctgtggggaa caaaaagctt ttgtgctttt tttttaacct 29880ccctttaaaa
tccaagggct ttctaaattn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 29940nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 30000nnnnnnnnnn
tctccttttc cttagaatac tgtatcagcc tgattacgaa ttatggccac 30060tgtgctctaa
aggaatcttc ctggtttctt tgccacactg accacgaatc catttcactg 30120ggatgagttt
atatcatttt ttagaaagac atatcaaagg tgagaaggtc agtacaggtt 30180tgataaaaac
ctatcaaact tttatagtca caagtttgac ttcccctaaa tggtacccgg 30240aagcctcttc
cagcagactt cccaccaaaa ggtatttata gcaataaaag tgattgaaat 30300tgaaacgttt
ggtacagcgt ccattattaa aacgctgctc aagaatgtgc ccctagtggt 30360acagctatgg
taagtcccac cattcataca ggtgttcttc cttactctgg cgctgatgct 30420gccagggtag
gatcatgtta catcggcctg tggcttctca gctgagacag cgtgggctgc 30480aggctgttgc
accgattcgt cgtctcaaga aaagcacagc cagcccgaga tgcacgcact 30540ctcccctgga
gcctcttaaa gctcaagtct ttaagtccag gagttcaaaa agtccgcgtc 30600ctaaagcttc
gcttgtggct cacccatacg gttcgcgttg aagaattgtg tccccacgcc 30660gagctgttgc
cgcgccttcg cgctgccatg gcggcagctc cggcactcac catactgata 30720tctggagcga
tactttctgg gaccannnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 30780nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 30840nnnnnatggc
cactgtgctc taaagcagcc ctaagtttag cagcttactg aaggtgctat 30900tttggataga
aagttgaaac tctgggggct aattccattc tcacactcca cccccaggtc 30960tactaaatgc
ttatcagctt aaagagagta ctagatagga tacaaagtgt ggctcaccct 31020ctctgtgggg
cagtatcatg gtctaacagt attattaccg tatggtccat tgaactgggt 31080cgaattagtc
cctcatttcc acacttctct tcattagagc ttgagcatga cctcatttat 31140agatggaatc
tttgtggtgt taccagttaa gatgagccta tattcagtta aggtggtgtt 31200gaattcagtg
tggctgatgt ccctggaaga aggggcaatg gcatgcaggg ggaaagttta 31260agcttctggg
aggtgagtgt cagcagcaac acaactgcac atctcatttc caggatgggt 31320tccttctgct
tccctgcctt aggggaatgc ctggtttgtt ttatgtcagt gatgatgaaa 31380aacatgatgg
gacaaagatg tcatgacttt agaagaaggg catggaacat tagaggctga 31440cttgtcagag
cctggagacc agccttttca cggttctaga atgaaacagc tcctgtggtc 31500agagccagag
ttttgtcttt cactttgnga ctatttctct gntctccctg attttccata 31560naccanngct
ctccatcttc tcctcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 31620nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 31680nnnnncttgg
aaagcatccc ttcgggcggc cttttctttg tttcccgaac ccctggcccg 31740agtttacccg
ggaataacct tgtggcccgc gtctttttct ttctcccttt caaggaaaaa 31800ccgtggggcc
ggctttttct ttaattaagc tctacacggc cttgggaagg ggttattctc 31860ttaaagtttc
ggggaggtaa ggggtatcgt ntcccccttt ccacaaactt tggtgggctt 31920gtgggtagac
aacacaaaac ctcctccctg tttttaaaac ccccccaaac ccgcgtttgg 31980ctnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 32040nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnatggccac tgtgctctaa 32100agtctccctg
catttctata ataaagctct taaaccatag agagtctctg ctcatcaagg 32160ctgcatgcac
tctcgtaggt attgggaaca tcttccctca tccctctctc ctataaccct 32220ggtggcttta
gcaaagtagc tccagggtcc ccaggtaggg ctgcccctgg ccgtcccctg 32280aagagagggt
cagaggcttg gatgcccatc cagggatgag tggaaaggta gcagccctcc 32340cacacctgac
aaaccagaga ataggtaaaa ctctggtggg gcatgggtct atctcccccc 32400tcttcatccc
cagggccccc ttttttagct cccacagaat actgacttcc aggcagctag 32460gatgaaggtc
ttaaagccca tgcccacagt gatacatcta ttccaacaag gccacaccaa 32520gatgagccta
tattcagtta aggtggtgtt gaattcagtg tggctgatgt ccctggaaga 32580aggggcaatg
gcatgcaggg ggaaagttta agctttggag caatactgat tagaattaga 32640atcctagctg
tgctacttat agcctgagtg gtccagggca agagatgttc atctcagccg 32700ggcgtggtgg
cacacgcctt taaatccagc actcgggaag cagaagctag cggatttctg 32760agtttgagcc
agcctnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 32820nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnttctt 32880ctcctttgta
tancatcatt tngacctcga tacgaattat ggccactgtg ctctaaagtc 32940tgcataacaa
ggggacataa ggaactcctt ggtcacctac ccccaattct caaaactctg 33000tgacagtgat
aaaggaatgg tctgtgtatg atgtagtaat ctcattttca ctagaaatgc 33060gtcacatggt
agtctcctgc tgtcactcac agactcacag actcatgttt gaagaatggg 33120aagcttccac
ttggcactgg agcggaaggc ctccatctgc tttacctctt ctggacgctc 33180atccacaaac
tcagccacct gcaggagtag gggcactaca gtgaggaaac ccacaggacc 33240cagccaagga
tcacttgtct caagaaccca gagccatagc ttacaggcag agaactgcct 33300gcttctcctt
gtgatcgcat gactgacttc tactgcccat catgagacta tcataccaaa 33360cagtgctagc
cgaagatcaa aaattcaaaa ccattttctg ctgaaaatgt atcatgtcca 33420caccactgca
cagtccaaac attaagttgg gagcaggtgt ggtggcgcac gcctttaatc 33480ccagcacttg
tgaagcagaa gcaagtggca atctgaattc aatgacagcc tggtctacag 33540agtgagtttc
aagatagcca gcgctacaca gagnnnnnnn nnnnnnnnnn nnnnnnnnnn 33600nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 33660nnnnnnnnnn
nnncagcgca ctgggggtca gagcccccaa tcggaccatc agcccttcac 33720cagacctgtc
ccaagccctt agtgtcgtcc tttgacagtg gtgtcggtgg tgctggcctc 33780ggttctgctg
ctttgagtgg tgaacgtgct ttgcgaattt tgtgggagtg atgggattta 33840tgtggaagag
ctgggctttg tgggtggtgt tcttaccttc tgggtagtca ggctgacacc 33900atgtgtacta
tcctgaagta gtttggactc ttctgaatgg aaggcgggaa gaagaaagat 33960ctgggttggc
atctgatgga gagatggtct ggttatttcc caagctttgg tgtatcaatg 34020ttattcattt
agtaaatgtt tggtgtctct ggtgccagtc ccactaaagg acagagtcct 34080tgcactgccc
tgtgcaggtg atctgtgctg agacagaagt tgtgaaatgg gctaccttcg 34140ctggtgctga
agctaccaac acttccggga ttccaggcag caccttcctt gccaattcaa 34200gagtcacttt
ggaaggtgcc aagatgaagg ggtgaatggt agtgagagaa atgcctatga 34260tacgcactat
cttcactctc tgtcacacca caccttctac acaccccnnn nnnnnnnnnn 34320nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 34380nnnnnnnnnn
nnnnnnnnnn nnnnnnnatt atttatacgg atggcaagct catgtgctct 34440aaagctncca
agacagcaat tgcacctttc agaacagcat caatgtccaa acatgagcca 34500ggtcctccca
aatggcaggc gcatcagtct ttagagcaca gtggccatnn nnnnnnnnnn 34560nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 34620nnnnnnnnnn
nnnnnnnnnn nnnnnnnnaa atttaagatt acgcatggcc agctccatgt 34680gctctaaagt
tgaaacctaa tgtatagcac atggtaatgg tgtaggtatt cttgcctagg 34740tgagaggctc
cattctgatt ctagagttcc tgtccccttc aggtccctgc agtttccctg 34800tctcaggatt
ccaagcacac gcctgtaatc ctgttttatg ccgtgtttga gatcaatctc 34860tggactatgt
atattttagg taagtacagc ttacaaccct tctttaacga cccatgtgct 34920gggacagagt
gggaagcttt ttccatgact gggactacag actcagaagg tggccccagt 34980cttcctgagc
aatgacgtgg ctgcttttta gtttctattg gctatatggg ctcttctctg 35040accctaatga
caaggtacaa tagcttgtag gtggtgactc agtttcaggt tgttatgtta 35100acttcgtgtt
ggttcagatg ggggagtgag gcccgtggct tttaaccaga tattaagaga 35160taactaacat
tctaactttg tcttcaaact ggtactggtt tattaatttg ggtggctttc 35220tttgtttcta
gatttaaatt aagttggctc tctgtgtgtg tggtcatctg cttaaggtat 35280agaatgaaac
ttggacttgg tgtatactta acaagggcct ttgannnnnn nnnnnnnnnn 35340nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 35400nnnnnnnnnn
nnnnnnnnnn nnnngtgtgt agtacgtgat gggcaagctc catgtgctct 35460aagttccacc
gcctttgcaa gctagatctc cctttcttct cttaatggcg actcgcaagc 35520tcgaaagcag
ccacctcagt ggtgagccaa ctgttggccg gttaggcaag cttatcttcc 35580ttcttccaga
gttccagcgt ggcactaatt atgtccctgt ctgctcagag ttcacctgcc 35640tcagctgatt
acctgctgct cacaagaagc acaatgagaa ccctgtatgg agctgatctg 35700agtggctagt
tgcaagtgtt ccctccgatt ggcacacatg tgtactgaat ttcctcacaa 35760cccatctgct
ttcgccttct ggaggaggct gcattccact atcccaccct accccaagaa 35820gactggaaga
aacaagatca agccatggct ggcgaccttg ggaaacatga cctggggagc 35880tagggacagc
catcaaatgg aatggcttag atgccagtca ttaaggaata cagaaggaca 35940tcaactctct
tggtggccgc ttccctggaa tcagctaatt tatctaatta gagttagagg 36000gaaactctgg
ttctctcttc cacggaaaga attcttaata acagagcctt accaaagact 36060tgcttggaga
atactttaag aattactttc cacaccccgn nnnnnnnnnn nnnnnnnnnn 36120nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 36180nnnnnnnnnn
nnnnnnnnnt caaagtctgt ggtgctgagg agacttctgt ggcaaaggcc 36240acatgatcct
gggtggaaag tggtatgggg gctccaagct ttgaggtggg aggtatatca 36300gaaacctcag
gtaccccagt ctgtcatcta gaacacccag tgttcagcca aagcaacagg 36360acccccaaac
aacaaaagca ctcccagtta ctggaccaca agatgcagac cacaagaaaa 36420tgataatagg
caggtagatg atgccagatt taccagaaga aaacataaag atgatcacag 36480acacagaggg
gctcaccagt gaagcaacaa cggtaaaggc aggaatcata atgtcacttc 36540agataaagaa
tatcaacagg agacattgtt ttaaaaaatt attgggctgg gaaataagta 36600aatcattaga
aagtctccgc aacagagttg aactgcctga aagaagaaac acaaactcaa 36660ggatagatca
gtaagattgc tttagagcac agtggccatn nnnnnnnnnn nnnnnnnnnn 36720nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 36780nnnnnnnnnn
nnnnnnnnnt catcccagtt ccagaaagac aaatatggta tgtatattct 36840cacatatgga
tattagcagc accctactac ttggttccag tgataaccaa gctacaatcc 36900ataaaaccac
aaagattagg catagagtaa aaaacctgag agaccagaca gccctcctta 36960ggaagaggaa
actgaataga taattatgga tgggtcccag tgggtgactg gaacaggagg 37020atcaagttgt
ggaggagaca aggggggaat atggggagaa acaactcaaa ttaagaaaca 37080tttgaaggga
tttctggaag cctaatacag tagaagcttg gtgtgacctt tgctgtacat 37140aaccagtgtc
tctctcccag gacttctcct taattttgta gccactcttc ccactgccac 37200taatacctca
agccagtcag cctgtggttc tgcctgtggc ctacttgagc tgtgtggacc 37260gagaacgtac
cctctggctc accccctcct cttgggatgt ttctttctgc tttagcgctc 37320acacatgcct
taaaccacta cttattttgc tcctttagag cgcagtggcc attttcgtgn 37380cgtggtcatg
atgctaaagt agcccgccgc cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 37440nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 37500nnnnnnnnnn
natggcccgt gtgctctaaa gccaaaacaa aacaaaacaa actatttgat 37560ttactgtaat
ttggctctcc tagtctctga taaatcatgt ttgttacaaa ccatgtttgt 37620tttgttttgt
ttttaaggtt tatttatttt tattatgtct aaagtgctct gcctgtatgt 37680attcctgcag
gccagaagag ggcaccagat ctcattatag atggctatgt tggaaattga 37740actcaggacc
tccatagcca tctctccagg cccagaccag tgtttttgag tgaagcttaa 37800ccggcctctg
tgtactcaac tttgtgaatt aagaacaact tttttctttc ttcttctctt 37860ttcttttctt
ttcttttctt ttcttttctt ttcttttctt ttcttttctt ttcttttctt 37920ttcttttctt
ttcttttcct ttcctttcct tttccttttc tttccttcct tccttccttc 37980cttccctgga
aaaaaaggtc cgatggtaaa tggaccttta aagcgattgg agcttttttg 38040aagaaacaca
cataactgtt gccctgctga taaaaacctt tgatccttgg ggctttaacc 38100tctgccttag
attcgcccgg ggcttgtgca aaaaacatag aaatttccac ggggcttttt 38160tctacctttt
tttttccaat cacagctttt ctccaaagtt tttactctct agccaacttt 38220gagagacccg
ataattggct tcttgcgcgc cctttcaagg gtgctgcgaa tttattattt 38280aggttcttgt
gccgacttta aatnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 38340nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 38400nnnatggcca
ttgtgctcta aagccctccc cagccctggc tccccattcc tgctagcact 38460accccttgtt
gggtacatat tcccagaagg ggctggcacc attgaaggcc tgcgcctttc 38520tgtgaccctt
tgccagtctg agaagctttc tactgactac tgagtggaga ggaaagaggt 38580ttatttgttc
tcatcttttc acagaatctt tgatatacga tagaaaggtt cacaaaaatg 38640agccagttaa
attactgtgt cagtcgctcc tgaacactga ctggtgcctt ctcacactgc 38700tgcgtcaatg
gccacctacc agaacctcta tctccaacct ctctcaccca agctgctgaa 38760gctagtagct
tactgatcac caggggttta gttcagggtc tgatacannn nnnnnnnnnn 38820nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 38880nnnnnnnnnn
nnnnnnnnnn nnnnnnntct tcctcttctt ttacggtcgg gccaagctcc 38940atgtgctcta
gagcacagtg gccatnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 39000nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 39060nnnnncgata
cgaatatggc cactgtgctc taaagagctc cttcagtggc tcctccccag 39120cactaagccc
ccaaaagacc caaatacagc tgatgcccat cctcaagtag attcaggaag 39180ctggcagact
gctacaaagg cgttgcccct acgccaatct tctcccaccc acctcattag 39240tccgatgccc
acaattctca cagttggtgg ccatgatgat aacctcttta aagtggggga 39300tttctggaag
atggagttaa agaagtctat ctgcttcaag gaaaacaccc ccacccccac 39360ccccaaggaa
aagcaaagcc aagtcccaca caaacagatg caggacccaa gagtacaata 39420aacgggcctg
tgctcacaaa cacggagacc tggccacact cagaagccag gtatgcagta 39480tgtagcttca
ttaaaggttc atcctcacca ctgaggataa agcactggct ttccctgaag 39540ggaaggctcc
cgtctgtaat ataacgttca tgcccgagtc agctgaagag caacccaatt 39600gcctgctgaa
agatacggac aagcttatgc tggcctccgg gtgaattcaa caaatattaa 39660atgtcttgta
tgggcccgac tttgggctgg ttgctggaga ttgtggcctc tatctttaat 39720aaactctaag
tccacaggcg aaggaaaaca tgaagttcgc tgtactacag agacctctag 39780cacagttggg
aatataacgc atcatggagt gagcccctga tgccactgtg tcagcagcaa 39840gggacaggga
gaatgtccag gctttagagc attggagctt gccaatccgt actcagagna 39900annganaccc
cctacnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 39960nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnatggc 40020cactgtgctc
taaagtcctt tctcttcaac ctccagtcgg tccccctgcc tccacccaca 40080cgctgttccc
gtcactttcc tcagaacttc cctctgccct tcaccgtgac cagttcagcc 40140tcctcccttg
tctccacaca aaacttctgc catcctcgat ccacttacct ctcaggcaca 40200gggggatgtc
tgcctataat cacggcactg gggaggctga ggcaggagaa ttgtaagttt 40260gaggccagtc
tgggctgctg tgggaggtcc tatctcaaac aacaaaacta agaagagaaa 40320aagaagctgc
caagcttggg ccaactggtg gaggagatgg cccaagtctg agaagacata 40380tgggatgaag
gcgggggttg gggtgagggc gtctccnnnn nnnnnnnnnn nnnnnnnnnn 40440nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 40500nnnnnnnnnn
nnnnnngacc atgattacga attatggcca ctgtgctcta aagctctgga 40560aagagctctc
ctgagtcaga agttattaaa aaaaactaac aaacaaataa agcactgatc 40620agaaagcatt
ccttcaaagg gaccaacatt tgctatattg tttgtaaaac aactcgcatc 40680cacgaacaac
acagtgggca atcagctaag aattaatgga gttgaatggc tgtgtttggc 40740taagaaaaga
ggtgtagaga cttcagttca aactagggag atcccagaat ttgccaggct 40800gttttgccca
gaagagagga cccaaatcct aagaatatgg atggagtcaa tccaagtgtt 40860gaaaaggaac
aaagcagaca gaagcttcaa gcagtggtga gctagtgaaa tgcccatgga 40920gtcctacttg
ttttagtaac atacaaggca gattaatcag ggctggggaa aggatgtcac 40980ggtccagaca
ctgagttcac caaggatgct tgcagacacc tgttctctct gcacttcagc 41040ctctgaatgg
aaacccagca ccggtattat ctcccctcac atcggacgcc tacactttca 41100gtattttcag
gcaatagaca ggtttccgtc acccagggat gttcttcgag ctgtctttct 41160gcatgaaacc
atttctttct cattatagca agaatatccc aggttcaagg tgtggcaccg 41220ttttccggac
tctcaggcag tgaagtcggc cccagctctt tagagcacat ggagctggcc 41280agtccgtacc
acagagnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 41340nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnntgat 41400gaatccccta
atgattttgg taaaaatcat taagttaagg tggatacaca tcttgtcata 41460tgatcaaatg
gtttcgcgaa aaatcaataa tcagacaaca agatgtgcga actcgatatt 41520ttacacgact
ctctttacca attctgcccc gaattacact taaaacgact caacagctta 41580acgttggctt
gccacgcatt acttgactgt aaaactctca ctcttaccga acttggccgt 41640aacctgccaa
ccaaagcgag aacaaaacat aacatcaaac gaatcgaccg attgttaggt 41700aatcgtcacc
tccacaaaga gcgactcgct gtataccgtt ggcatgctag ctttatctgt 41760tcgggcaata
cgatgcccat tgtacttgtt gactggtctg atattcgtga gcaaaaacga 41820cttatggtat
tgcgagcttc agtcgcacta cacggtcgtt ctgttactct ttatgagaaa 41880gcgttcccgc
tttcagagca atggtcaaag aaagctcatg accaatttct agccgacctt 41940gcgagcattc
taccgagtaa caccacaccg ctcattgtca gtgatgctgg ctntaaagtg 42000ccatggtata
aatccggtga gaagcttggt tggtactggg taagtcgagt aagaagaaaa 42060gtacaatatg
cagaccttag agcgcaaact ggaaacctat cacacnnnnn nnnnnnnnnn 42120nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 42180nnnnnnnnnn
nnnnnnnnnn nnnnncttgt tacgcgctgc tgggctccat gtgctctaaa 42240gctttagagc
acagcggcca tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 42300nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 42360ntttcgtcta
cacctataag atctctttcc attgaggagt tcctcgggat catgatctcc 42420cgcctcccta
agcagacggc gcgaaggatc gaccatagct gcgtggtaaa caccgacgcg 42480tactcttcat
atatacgcac ggcgcgataa cggaggaacg ggtgtgctct tgcgggaatg 42540ttcagataat
caacgggttt gtcgccgcca atgtccatag tgcgcacaat aatgctgcgt 42600ccgttggcgg
attccagcgc ctgacaaaaa atgttgtaca actcgctttc gcccggtgcg 42660ctggtgcgat
ccatatagag catttcagtg cggaacaaac caacgctttc cgcaccattg 42720ccgaatgcgg
cctgcgcttc cacggagtga gcgatgttag cggcaatttc aatgcggata 42780ccgtcagcgg
tacgggcttg ttgggtcagc cagacacgct gttgctcacg cagggcgtcc 42840tgtacgcggg
cttcttgctg ataataacga gctacggctt cccctggctc aaccacaatc 42900gccccggcgt
cgccgtcgat ataaatcgtt tgttgctgcc acggagtaag ggcatcaata 42960tccacaccaa
ccagcgttgg aatgttgaac gaacgggcaa ggatcaccgc atgtgaggtg 43020gtgccgccgc
ttttgagcaa caatcctttg aggtgatttt tatccagttc gaggaactgg 43080ctgggggtca
gttcatcagc catacaaatg gcgggctgcg tcagtttgcc cggtgccggg 43140aagcgttgct
caccgtagat ttgctggagt aactggaagc agacgtcgcg tacgtccagg 43200gcacgttctt
gcaagtagct gctgctggaa cgggaaaact cttcgcaaaa gtgattcgcg 43260ctggcaacaa
ttgcttcggc gcagcttaat ccggcgctga cgcctgccag taaatgttcg 43320cgcagggaag
tatcgccagc ctaggatcgg ggagctttca gaatcgcgct ggtagcaccg 43380tcgctatcca
gcaaacgaaa ctcaatgttt tttagtacca gcgtcaggcc gttttccagt 43440gcggattgct
ctgcgtcaac gcctttggct gcgggaagat tacccagcgc attgagatct 43500aaaaaaaaga
tctgcgtcgg aatgccgcct gcactatcgg tgcacaccgc gcgggcgctg 43560gataattgcg
gattcagatt ggtcagtgat acccggagat gtttcagttc gccagattta 43620acttctgtca
gcggcgcatc gcagtgtgtg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 43680nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 43740nnnnnnnnnn
aaggacaatt ctataaattc ctctgatcgc gcatggcgca actccaatgt 43800gctctaaagc
acagtggcca tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 43860nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 43920ntagccccct
tcctaaatgc tcatagcact gacaggcaac ctctaggctc aggatccctc 43980ttgcctggca
tgcacctgta tgatcttcat gtctctctta tgtcaaatgg ctaattctct 44040tttgtatcat
acctgctggt ctctcgggca tccttacttt agagcacagt ggccatnnnn 44100nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 44160nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnncata caaacaatca tgacctgcat 44220tacaattatg
gccactgtgc tctaaagaag agcaaacagt aagagtccca caatgtgctc 44280tggcctaatg
gcacagaggg taacaaaccc cacttatgag acaattcttt tgtcacctat 44340gtataagaaa
agagcaagca ccaggaatat tctatagtta aatagatctc aagaagtaag 44400attgaatcac
agtgacctag actatagact gagaccgtct caaaggttta aaaaaaagaa 44460aggaaggaaa
ggaagacaca ggggatggag gagaagatgg gagagccttg tttatggaaa 44520gtcaggagaa
cagagaaata gtcacaaagt gaaagacaaa actctggctc tgaccacagg 44580agctgtttca
ttctagaacc gtggaaaggc tggtctccag gctctgacaa gtcagcctct 44640aatgttccat
gcccttcttc taaagtcctg acatctttgt cccatcatgt ttttcatcat 44700cactgacata
aaacaaacca ggcattcccc taaggcaggg aagcagaagg aacccatcct 44760ggaaatgaga
tgtgcagttg tgttgctgct gacactcacc tcccagaagc ttcccactct 44820gtcccagcac
atgggtcgtt aaagaagggt tgtaagctgt acttacctaa aatatacata 44880gtccagagat
tgatctcaaa cacggcataa aacaggatta caggcgtgtg ctctttagag 44940cacagtggcc
atnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 45000nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnatggccac 45060tgtgctctaa
agagagagag gggaaacaat aagtagacat acttgtgagg ggggacctat 45120tttcaataaa
gacagaaaag gggaaacacc ttccttaaca atgagtcaca tctgtccttt 45180aactccatct
tcctctatgc tgggatcttg ctgggaggag tgacatcttc atccttgcca 45240cactgtatct
gtatttctgt ctgtcactca tccaattgaa gtttatctca tttttttttt 45300tttttgggcg
ggtggcctga actcatatgt agaccatgtt gtccacaaat cacagagtaa 45360gtgacacctc
tctgcctctg cctctgtctc tgccccctct gcccctctgc ccctctgccc 45420ctctgcccct
ctgcctctcc tctgcctctc tgcctctctc tctgcctcta tggctcatct 45480ctatgcctct
ctgcctctct ctctgcctct ctgcctctct ctctgtctgt ttggctctga 45540gacagggttt
ctgtatgtat ctctgacttt ctggaactca ctttgtagac tatgctgctc 45600ttgaactctc
aaagatccac caatctccac tttgtgtgtg ctgggattaa aggcatgtgc 45660catcacacct
ggcataaatt aatgttttta aactcactta tcattgcttn gctaagaaag 45720aatgagcctc
gggaaccttc aaccttagtg ggagccattc tctgtcagtg ggtccctcac 45780aggatcacta
gtattctacc tgtctctatg cctttataca agcttatttg gtcacctttt 45840aaaaaattgt
tgccacccat caaaactaac ttgggccaat ctggggctat tttaatggtn 45900nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 45960nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnng cgccaaagct tgcatgcctg 46020cagccgcgta
acctggcaaa atcggttacg gttgagtaat aaatggatgc cctgcgtaag 46080cggggcacat
ttcattacct ctttctccgc acccgacata gannnnnnnn nnnnnnnnnn 46140nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 46200nnnnnnnnnn
nnnnnnnnnn nntttaggtc gcgactgcca gctccatgtg ctctaaaggc 46260tagatctctt
agttaaagga cttttcacag gttattggat attttcaaca gaacatgcta 46320tggcattctc
tctctctctc tctctctctt tctctctctg tgtgtgtgtg tgtgtctgtc 46380tgtctgtctc
tgtgtgtgta tctgtgtgtg tttgtgtgtg tgtgtgtgag tgtgtgtgtg 46440tgtgtgtgtg
tgtgtgtttg gttggttttt caagacagtt tctctgtgta gccctggcta 46500ccctggaact
cactctctct gtagaccatg ctggccttaa actcacagag acccacctgc 46560ctctgcctcc
caagtactag gattaaaggc gtacaccacc ccacccagct agtatacact 46620cttccctgct
gagccatttc ttgtcccaag gctgacattt ataatctgtt aactgtcatg 46680atgtaaagtt
gggttaaagg tatcaatgac gctggctcag gtaaacctag taccttactc 46740taaggtacta
agaatatact tttaaaactt gctataatgg ctatggaacc accaaattgt 46800ttttcagtct
tgaggatagc ctgatctcta atattataga gtctattaca ggtgagggct 46860ttttgagagg
ggtgtgtgtg tcgggggggg gggttaccct ctattctagc cacttctcta 46920ttgatcattt
ttcttggtgg aaacttcata ttacctataa aaattaatat tttagttcta 46980agaagagcag
atgcagatat aaagatttat gtgccatggt aagtgactca agtatgcttt 47040tttgtgttcg
attataggac tttaaaaaat aagagaagct aggatggaca gagctctaca 47100tgaggccaat
cttccacagt gtagtgtctg ctccagtcta aggattggtt gctaagactc 47160tgctttttga
cacactcttc aaacacagga aatgcttctg atgcttatct tcatgtgtgt 47220ttgctaatgt
gcatgtaatc ttatgcaggg ggagttgaaa aggaacgtgt taagtgttat 47280aattctggaa
aagtaccatc aagccctgag aacccttttc caatgtgtac tttctgtttg 47340tgtgtggttt
tgtgtggagg agggcagggg tccaagacag ggtttctctg tgtagccatg 47400gctatactgg
aactggatct ttatgccaga ctggccttga actcagagat ccaaatccct 47460ctgcctccca
ccgagggagt gtgccaccac tgccaggcac atatgtactc gttgtgtgca 47520ccctcatcac
agcaggctca ggcttaaagt ggtttaggct caggtgctag tgtgcttcat 47580tgatgtgcac
aggagtgtgc cttattcccc ttcagctctg ttcaggcttt gttggttcat 47640ttgttttaga
tgtacttaca tatgtaaata aatgttttgc ctgcaggtct acccgtgcac 47700cacatgcaca
cagatacctg atacctgtgg aggtcagagg aagtcctcag acctagagtt 47760ggattaacaa
tggctctgag ccatgtgcac tgctgagcta tctctcaagc ccctctgttt 47820actttttaac
tgttaactga tgcatactcg cttgcttcct taagctgcct gaggggctct 47880gccagcatct
tgggtgggta ctgactctac tcttgttcac cacagaccac ttggtagccc 47940atggaagaat
ggcagagaag gaagctcgac ggaagttcaa acagatcgtc acagcggtgt 48000atttttgtca
ctgtcggaat atcgttcatc gtgatttaaa agccgaaaac ttacttctgg 48060acgccaatct
gaatatcaaa atagcaggtg aggtgtgtgt gcacgtgcgc atgtgtgtgt 48120gtgtatgtgc
tgaagacagg agtcatggtt aaagtaggga cagtttaggc ttttttaaaa 48180atgagagctg
gggcttgttc atgctggagg cacttttctc actgagctca cccccactcc 48240agacttcact
ttaataacct gaaaattaat aaacttccaa aggacatttt aaaatatagt 48300attagctaga
actctttaag aagaaagaaa aaggtagtat ttcaaattct attactttga 48360taaatccttt
gtcaataatg tagagtagac tatttttttt atagcaagaa agaaaactgc 48420tgaaatgatg
tgctcagctt cttctgccta agctgtttgc actgccccag ccncagacac 48480agccacagcc
ccaacacccc accgcgcaca tccnnnnnnn nnnnnnnnnn nnnnnnnnnn 48540nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 48600nnnnnnnnnn
nnntctcgat caacagctat gatcctgatt acgaattatg gccactgtgc 48660tctaaagcca
cataaagacc caacaaaaaa agagaattac agtgatctcc cttatgaaca 48720tagatgcaaa
ttttctcaat aatatactta caaactgaat ccaaggacac agcaaaaaca 48780tcatccacca
tcatcaagta gtcttcatcc caaagattca gggatggttt gacatatgta 48840aatcgataaa
tgtaatccgc catataaaca gactgaaaga aaacacacac acacacacac 48900aatggttatc
tcattagaca tagaaaggcc ttttaaaaga atccaacacc ccttcatgat 48960aaaagtcctg
gaaaaattag ggatacaagg agcatacata aacacaataa agaaagttta 49020cagcaaacct
atagccagca tcaacttaaa tggagaggaa acacaaagca actcccctaa 49080aatcaggtac
aagccaaagc tatccactct cttcatacct actcaataca tgacttgaag 49140tcttagctag
atcaataaga cacctggaag aaaccaaggg ataccaatta gaaaggaaga 49200agtcaaacta
cctttatttg caaatagtat atttaagtga ccctaaaatt tccaccagga 49260accaacctcc
tacagctgat aaacactttc agcaaagtag tggatacaaa attaactcaa 49320aaaaaaaaaa
aagaaagaca gtaagatgct tcctttatcc tactgcagac attcgctcaa 49380ctgtgttcat
tgctgctctg ctcctaatag tcagaaactg ggaacagcct agacgtccct 49440caacagatga
atggaatata tatatattta cacaatggaa tattacttag ccattaaata 49500attaaatcat
gaaaatcaca ggtaaatgga tggagctaga ataaaatcat cctgagtgag 49560acatcccagg
tccagaaaga caaatatggt atgtatattc tcacatatgg atattagcag 49620caccctacta
cttggttaca gtgataacca agctacaatc cataaaacca caaagattag 49680gcatagagta
aaaaacctga gagaccagac agccctcctt aggaagagga aactgaatag 49740ataattatgg
atgggtccca gtgggtgact ggaacaggag gatcaagttg tggaggagac 49800aaggggggaa
tatggggaga aacaactcaa attaagaaac atttgaaggg atttctggaa 49860gcctaataca
gtagaagctt gctaagatag atccatatat gaaggcagtc caaatggaat 49920caccaaatat
tggaagatac aaggccctaa ctaaacatct ctgtcaccaa atgaagcttg 49980tacatttaat
tgagttattg tacaaaggag accctatgcg aacctttcaa caacccaggc 50040tgctgctaag
actacaggtg gatcttcaca aactgacagc gaggccccat tgctgaggct 50100aatacccaca
caactcgtag aacatgaaca agtcaagccg gtgcctacac ggagccttca 50160cacctacatt
ccagtccttc tttggtgcag gaaggtacgg tgcatgctac caaagagaaa 50220tataaacacc
aagccagcca tagcctcaca tgagagtcag agcctctcct ttcttctttt 50280taatctcctc
ttatttttat tttattttat tttattttat ttacatcttt ctctccttct 50340catgtacatt
atggcttcca gtctagtgtt tttatgggat tcatgagtgt gccaccaaag 50400ggtctctgtg
tctgtatcta tttcttgtgc cttgggttct tttctgtctg cttgttttgt 50460cttattttga
tgtgttaatt tttgttttct tattttattt tattttattt tattttattt 50520tattttattt
tatcttatta gtatccctta gaagattgtt tactaatgag agacagaaag 50580ggggtagatc
tggatgggag gggaggtggg agagcactnc aatgggaacc ttcanntacc 50640taccttcgat
ccagaactat tttcaataca aactcactac ggaaacacct ccgttcaaag 50700tatcacatcg
tcctttactc ctctttcttc tactggactt gctggacgaa gactcctctt 50760ccttgccact
gatccagttc tgacgccccc tccactaaan nnnnnnnnnn nnnnnnnnnn 50820nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 50880nnnnnnnnnn
nnnnnnnnnc ctccccccct ttttgtatca tcgtaccagc cagctccatg 50940tgctctaaag
cacagtggcc atnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 51000nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 51060nntgagcttc
aggaaccagt gccccaatta ctgtaaggtg gtggcaagcc aataaataaa 51120tgtgtgccac
acagatgaac tgtgctgcaa ggaggaggtt atttgaaatg ccaggaacac 51180atgacacagc
tttaatcaca acaaccattt cagacaagta gtaaggggct gggacttcag 51240gctcagagag
atgaacatct ctctcttttt tttttttttt tttttgggtt ttttgagaca 51300gggtttctct
gtgtagccct ggctgtcctg gaactcactt tgtagaccag gctggcctca 51360aactcagaaa
tccgcctgcc tctgcctccc gagtgctggg attaaaggcg tgtgccacca 51420cgcccggctg
agatgaacat ctcttgccct ggaccactcc agctataagt agcacagcta 51480ggattctaat
tctaatcagt attgctccaa agcttcctgg atgccagcaa aacccatatg 51540cattgaagac
aaagtgctaa tttaagagga agctgctgaa gtgtgaatga cttactatga 51600atgctctcac
ttacttaaga taacatttcc cagttgttag ttcagtttta aaagggataa 51660tttttatctg
tcccagccaa cttctaaata aatgagacag agactataag atttatttaa 51720ccaccgccgg
gtggtgtctc gaaaaaccaa aaaccaaaaa caaaaaaaaa aaagagagag 51780agagagattt
acttaaccca gctttacttt atggtacagt atctgagcat ttattagtct 51840gttttaatcc
tgcgagctaa cctggctacc tctcaggtgt attctcatgg tgtctctgtg 51900accctttcct
tatagacacc cgacccctgc tgggattgga agtccagcct tattctctcc 51960cccaatcagt
cattggatga tcagctttta ttgacaaatc agaaaatgaa tggggagcaa 52020tgtttacata
gcattgaaat aagagattat tagaataagc attgcagtgc catgtctgga 52080ttgcaaccag
atatgggggc agaaaatcag cattggaata acaaaggata atctttacac 52140agtgcacaat
aacattatgc ccacatccaa tggtgccaac aggcatgaaa cccaggaatt 52200cccacaaacc
aatttattta tgccatggag cattcaagga ctgccagtag ggcaggcagt 52260ggtgagggca
aaattgtgta accattgaat gctacaccgt gaggtccatg ttccattgag 52320aacttttatc
ttgttaaatt ctagatcttc acggacatta acatagcaca tactgtgtgc 52380cagcttgctg
tcacctttaa aacatatgtt attttaacca catacattct ttgtatcctt 52440ctaaacaaaa
ctagtattct cccatcaaac tggttcatta ttattattat tattattatt 52500attattatta
attattgtta ttattagact atgaagacta gtactctgct caaactttac 52560attggaggca
gataaccaca ccactgtgct tatctgatca ctgatcaaac aaataggagc 52620cattttcttc
ccagttaatt cctcatttgt tagtctgtag ttttgctttc ttaatatcat 52680acatagctag
tttatgtttg taatctgtac aggatgcctg cagaagccac tgtgcatttc 52740cctcagagcg
ccattggctc tcttctcttc tcttctcttc tcttctcttc tcttancnnc 52800ccnncncnnn
ncccccctcc ccttcnctcc ccctttctca tttttttttt cctattaact 52860tattatcatt
tccttcccta catcaaacat ttaaacacct ttcctgattt tcccttttaa 52920catatcaaaa
actttctcta attcaacagt taaccccaaa cacctcattt cacccctctt 52980tttaaacaca
cccactttcc ccataattca naggggcact taacaatttt ttccccaaaa 53040tgacccaaat
ggccaccatt tcccattcct ccgctattgg gtggtcgctc tcaaaaacgg 53100aggcctgttt
gggccccaag cttcttaaaa acatggcact tctaaatgag atcctctctc 53160cgcgacaata
acctcagcgg gattggttaa tagcacccca cctcttcccg ttaacgcccg 53220tggagtaaga
ggggaccaca tatggaccca ccctcttttg gggggatgat ttaggcgctt 53280gagcgcccca
taaaccccga atatatgtgc ctctcttttg tccgcgggtt caacttcata 53340agccagcgcc
ttttaaggac tcggagtcgg tcatgcgctc tcttttatta tagagacnnn 53400nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 53460nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnata taatagaata aaataataat 53520aagtttttaa
taagcggttt ggtcaagctc caatgtgctc taaagcacag tggccatnnn 53580nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 53640nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnntga ctatcagcta tgacctgatt 53700acgaattatg
gccactgtgc tctaaagctc tgcctagcta acttgtgcat tcctttctta 53760ctggtggtta
cttgttgctg tgacctgtca gcatttgtct gacagatgca agtgcatctc 53820ctgctgatta
gcagacagag agtgtatagc aactataaat agaaaatagg tggttttttt 53880tgttctttga
cagtttctat taatacattg tatgtccaga ggaaaataaa gtagtttgtg 53940ctgaaactga
agtattgttt gaatgtaacc gccttgcaca gccaaggact cataagctgt 54000cctcagattt
ccctgtaagc agggcaggag ttgagagttc agatttatat cttgttccag 54060gtcaaagcac
ctgagcaagg ccctgccagc tgtggtgctt ctgtctctta gaggcagacc 54120tatcctttta
agtcctagga atagtgtgtt tccatcccgg tctcagactg acggctgtgc 54180ttgtgttctg
aagctcacat agtcttccac tgtgttgggc cttggcatga cacagcaggc 54240aagagtcaaa
ggctttcttt atggctggag actaagccag gcactgtgac tcgtcctgcc 54300ttcgcctgtc
aaaggacatt actgtgcagg aaaccatggt tttcctttgt cttcatgtca 54360gttgtggcta
ttcccataga attaggtaat gtggaaagac ctggcaatgt caaaccttct 54420tttgtaatta
cctttttttt ttgtagcttc aatgaaatga actgtaaaca gcatatactg 54480aagctctcag
aactcagaca tgtgacatgg gatttgaagg cagcctggat gcattgcaag 54540accctgtctt
ataaaaaaaa aaagtgcatt gcaacaggcc tcttagctcc ttactgttgg 54600tgaaacaaat
tagcacaaac tccaaggctg caagcacggt ggtgttctaa gtcagctctg 54660gaggtcagta
gaataaaaaa catccggtta gcagctgtgg ttcctggagg acctaggggg 54720aaagcccaga
ttcttgcctt ttttaccttg tagagcgaac ctgcctttct tggcgcaggc 54780cccgtcttca
cagcacttcc caaacttcat ggttccattg tggtgactgt tctcctgatt 54840cctggtacta
aaaggagccc tgtcattaca tcaggtcctc ctagataatc caagactacc 54900tccacagttt
cctgatattg acttggtcac ttccatagag agctcctttg acattcacga 54960ggataggatg
cttgccacat gggtgtgttg gaggacacaa gccattccca tgccatcccc 55020agagcccttc
ccatgccatc ggattattaa gtagttgaaa gaaagccctt ctttatattt 55080tataattgta
ttctgcatat gtgacctaag tttaaagtgg tttttttttt ttttttttgg 55140ttttgtattg
tgttgtgttg ttttatgctt ggttcatgat ttttacgtca gggccattct 55200gattaagtta
aggaaaattc ctgtgtcaat tagttttttc tggagaaacc aaaaataaaa 55260gcaaaggtca
ttgataattg agactaaaat tactgaaaaa ttagtggaag gtgatttttt 55320tttttttttt
tttttttttt ttttagtttt tcgagagagg gtttctctat agccctggct 55380gtcctggaat
tcactttgta gaccaggctg gcctcgaact cagaaatcca cctgcctctg 55440cctcccgagc
actgggatta aaggcgtgcg ccaccatgca gaaggtgatt taaaaaaaaa 55500aactggaggt
ggggactgga gagatggttc agtggttaag agcactgact gttcttccag 55560aggtcccgag
tttaattccc agcaacaaca tggtggctca caaccatctg caatgggatc 55620tgatgccttc
ttatggtgtg tctgaagaca gctgcaatgt attcatataa ataaaaacat 55680aaataaatct
tttaaaaaat ttttttggta agtcattaaa acaaatccaa gcagttgcag 55740taagaatgta
cccactggag tgtgagtgaa gctgctggga cgctggcagc cagccctgtg 55800ccctctgtgt
tctaacacat aggctttggc acagttttaa agttcagttt aagtgtttac 55860attagtattt
gttttcagag caaaacaaag actaaattgg gactgtagtt catggttgcc 55920tacagtgcta
aatgtttatc tttgggtgac tgctcatgcg ctcttttttt ttccatgccc 55980ccattatgtg
gtttctcagt cattgctcga gcttggggtg tttgcacaag tattagatgg 56040gattctcatt
tacacttgcc ctatcttcct tgaacctaat ggatcactag gagaaatgcc 56100tttactgaag
tccaagtaga acccgagtaa cttcagagtg gactgggtga taagtaatga 56160aatcaatttt
atttctaaga gtgtaaagca actattagag ccctgttcct gtcagtggtc 56220attttggata
ccatattcga agccttagga agaagctact gtatatgaaa gacatatatt 56280tacaagagag
aaaatgagct ttttggttgt gtgtgtgtgt gtgtgtgtgt gtgtgtaaga 56340atcatcttat
atagctcagg ctggcttcca actcaagagc ctcctacttc agtctctcgc 56400taggttataa
tgtggtcata caccaccatc tctgccattc tgggggtggg gaggggaaaa 56460gagtgttaat
aaaccaagcc agagatgtta tcagtcctgg aacgcctatc ttagccacta 56520gtgaggctaa
agtagcagaa ttttaagttt gaggccagcc tggacaacgt ttggagaccc 56580tatctcaaga
aatgaaagtg ctaggcagaa tgcttaccta ctttcaggtc ctgagttcaa 56640tacaaaaaaa
aaaaaaaccc caaatcctca gtctttactc cctcatcttt aaattatgtg 56700tgttaaggaa
caacttattt tggactaata cagattttaa ttatgaaatg taagcagtta 56760acatttttat
gccaggtatt tatacaaggg gcttttgttt taaaagcatt ctggtagctc 56820agctactaca
ggtatttgct ggcaagttcg atgacctgtg ttccattccc agcacccatg 56880tactgcgagg
aggaaactga tgctgacaag ttagctgtcc tctgatctcn nnnnnnnnnn 56940nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 57000nnnnnnnnnn
nnnnnnnnnn nnnnnnnnng ggagaagagn agagaagaga gaggagagag 57060aaaaagggaa
ganaagggag gagaaagaag aggagagaag ggagaagaaa aggaggaaag 57120aagaaaggag
gagagaacaa ggagaggaga aggaagagag ggagnaagaa aaaggagaga 57180agggagaaag
gggagagaag aganggnagg aagagaagga gggagggaag gagggangga 57240nngnaggnag
ggagggaggg agggagggag gaaggaagga aggaaggaag gaaggaagga 57300aggaaggaag
gaaggaagaa aacttcagat caaaacaaga gttcagagaa tttcaaatgt 57360gaccaagaaa
gctaaggttc tacttagatt agaaggcaag gaaaactgcc ttatgtctca 57420caatgtagga
agccagtctt cttcaactct tcgactcaca aattctcttt tgttcttttc 57480cttttccaac
atttaaaagc atttagttag ttagttgggg ttgggggggc atgacttggt 57540atgcccaagg
acaacttgtg ggagtcactc tctccctccc tccctcatgc aagctccaac 57600tcacactgta
gtaccccaga gcttaccatg ggtaccagct accaggctgg ccttgagctt 57660gaagcaatct
tattcctctg cctgccaaat gcttcaattt cagatgtggg ctaccatacc 57720caggtacaaa
ctccttttaa aacagtattg tcttaaaacg tcccaagaaa gacattaaaa 57780aacaaacaat
aataacaccc ccccccccca gttctgttgt ttttgcttga tttacgatca 57840aatggtttag
gcctgtagta catggaaatc agtctcaatt ctcctaccca ttcttcaaca 57900aagaaacaaa
cagtctagtt aaggggcttg gtaaggtggc acatatgtaa ttccagaaac 57960ccaagcaggg
gaatcttgag tgtgaggcta gcctctattt gataaaagaa aaacaaaagt 58020ccttcataaa
tttcaagcag agtcatgata ccattaacag cacccacact aacttattta 58080tgaaaaggat
tcatttcagt tggatataaa agctgcataa acacggaaat taattaatta 58140caataggtaa
atgcttttaa tgactcggca ttttgagtgg acatactaga acctaaacca 58200ccaagtcagt
ttatctgaat tatttttgtg ttttgttttt gcaaatgata aaatgcatta 58260gcaagcatgg
ggccatgatt tataataaac aaacaaaata aataatatta tactatacca 58320agaatgcact
acagtatgta tacatttata gatatatggc tactagtata taatgtctga 58380attgattatg
tctgtctaca tcatgtgtgt atgttcatct gtctatactc aagtgttttt 58440taaaagtctg
gctttaaaaa aataataagt aaataaataa attaattaaa aacaataata 58500agtctggctt
ttgagcctta ccagcatgtc ttgatgctgt gataaaaagt gtaactaagc 58560cgggcgtggt
ggcgcacgcc tttaatccca gcacaggcag aggcaggtgg atttctgagt 58620ttgaggccag
cctggtctac aaagtgagtt ccaggacagc cggggctata cagagaaacc 58680ctgtctcgaa
aaaccaaaaa aaaaaaaaaa aaaaaaaaaa aagtaactaa tgaatctcat 58740gaggtgaatc
ttgaagcact gcataattaa tcctttattc tcattcattt gaacatcaat 58800attagtgttc
cctattcctt atatagtcca ggggttcata acatataaat ttaacaaaat 58860acaaggaaaa
tctacctcct ggtgagatta ccatggcaat cactaccaca agcgagcaac 58920gaaacgtgct
gagtgaggag cctgtccatc agcccctgcc cgaaggtgca cacacttaaa 58980ccactcagag
gctctcagag gagggtggga agacctacag aactactcca ttaattagct 59040cctaagaaaa
ggcaagggaa aatcgatacc attttgggag agagggtagt tgaaacaggg 59100tctcatttat
cccagggtgg tcttgaacta gctgcacagc aaatgatgtc agcctatgcc 59160tgaccacttc
ttcctttctc cccatcttcc cttctttaga gtgtattata cgcagcaccc 59220tacctctgag
ctatatccac tgtcttttat tatctttttt tgagacatca tgaagcaaag 59280gattaagtgt
ttctggtcat ttcagggtat ggcattgctc tcgactcacc ccagcccgtt 59340gtcctttccc
tctgctgtgt ggggaccaca gtggaaaaat atgacaagca gctctgtctg 59400cactggaaga
ggccttacac agtcattctt gacacctcac aacacacaac tacactgaca 59460agaaacaatg
ttccaatgtt aactctatac tctttccata aaaacatata tattcatata 59520aatacataca
gatatataca tacatatata tctctcaaat aattttgaat aaaagaatat 59580tgatattcac
ttacattgtg ctattcttag gaacaagatt taagagaaat gattttaatt 59640aaaaaattta
tttatgtatg tgtatgtatc tctgtgcttg aggactgtgg tgccctcagg 59700ggccagagga
gtgtttcaga ttctctgcag atggagctgt aaacaactgt aagtcactca 59760atgcaagtgt
gacaaccaag cacggggcat ttgcaagagc agtgcacgca catctttaac 59820ttctaggcca
tctctctgat cctcgaaaag atcatttttc agagtgtttt cctactattt 59880gtattattta
ttaaaattaa tttatgcctc atgtgggcat acatgtaggt acatgcagct 59940atgtacttgt
gggaagccaa aagagtggct ccccaaagcc agagctacaa gtgtgagcca 60000actttgttac
atggctgctg ggaccccgac tccagtcctc acggttgcat ggcaggcact 60060cttaaccact
gaaccatctc cagtttccaa tttttcacat tttactttcc aaccacttag 60120catgtaccag
aatcacttag caccgtctac atgagtgtca catgccattc cagggacaca 60180gcaaaagtta
gggtcaatta tgacctgaat ttaggaggtc acaacggtct tctctggctc 60240tcaacttcct
ggcctatcag cctgaaaggt gtgatgggta acccaaataa agtgttgggt 60300cagggataag
gaaggactct ctggggacag ccgggcagtc ccaaaatcac agcacagagc 60360agccgttctc
agcaaccagg gattccaccc tctgaactct cttctggatt gcaaaaggtc 60420agtgcactga
ctcacaaagt gtttggattt ttaataaaca ccactctttc aatctcactg 60480cgccgaggcc
cgaactttcc actgtctctt aaacccatgc actctggaaa ccctccccga 60540agggccagct
tttctgtagt taccctgaag gtccttgctg tctcctgact gccaacgaaa 60600acactaacac
gggagtggaa actgtcttgt ggagcccatt ctgggagtgg acatttaaag 60660gggaaagttt
ccaacttcct ttggttaaag aaaataagtt tccacaattt tcaaaacatt 60720ctcataatgt
ctgaaacttg aaagctcttt tctttaggga gtaagtcagc tatgtttagc 60780tttttttttt
agacattctt tttttttaaa catagacatc tcactactta atctttggga 60840acaagattta
aatggctttc aaactgcagt gtattgacca ttaaacaaga acataccatt 60900tactgttgat
ggctaaacat aatttttatt gctgacaatt atttgatgag aagttccttc 60960tccatggctc
agacacccta ttgctaccat gtcctggaaa tcattggctt ttcctggttt 61020tttgcccttg
ccacctcccc gtgtctgtga cttccgcgtt tttaactggt ccttttatct 61080tcttgccctt
ctttctcccc aaatcttttt ctatctgtag tgaaggttcc ttattatgtc 61140ttaatagtca
agcaatttca cagtttagtg acaaaaaaaa aaaaacctcc catttcttac 61200acatggtttc
catatcattt aaaaagaata ttgcatctac ccacatgcat ccacatgtgc 61260tgtggcacat
gtgtagagct cagaacttgg gagtcagttc tttccttctt cctagtttcc 61320gagacagtct
tgattctgtt acgctgtgaa ctccaggcca gttgaccgaa tagctttcca 61380gtgattctcg
tgtttctgcc tcccatctca ccatagaagt caaatgtatg actggtccca 61440tagcttgtct
gcaaatgtgc catgacactc tattacactt gggcctcagc ttcctagcag 61500aaccaaaata
aaatcccaca tcctggcatg tgcaaccggc cctggccatt cctgtcaccg 61560tcactccgtt
ctctctccct tcttagccct ggccatgctg accttctcct tttgactcgc 61620ctcttctctc
tctggccttg cattatcttc cttcggctta gaaggctttg tctactctgc 61680ttaaatcagc
ctatcacatc acacagattg catctttcaa ggtccttatt aagagttgtg 61740tgtctctcct
catcagaatg atattgaaag ggacagtttc ttctgctgct gcatccccag 61800gacctcaacc
agtgactaca cagtaggcag tttatccata tttgctgaca gagcctctgc 61860aagtctctcc
tctacaatgt ccctcaagcc ttacctcaaa tgttctatct tgagtaaggc 61920atttatgtct
atgtgagcac tagcatgaag tctgaatcag gaaagctatt gagggttttt 61980ttttctttag
tgtcccaggc ttctttattt aattgataag tgacagctta atcaacatga 62040gcactcaact
tcatcttcat ccatcacctt gtgctcctat cctcctcagc aaatgaagaa 62100cttcatcccg
aagccctggt ggcacagcct ccaagttctc ttggtctagc tctttccctc 62160tctctgttcc
ctacatccac tggcagggag agtgccccag tttaaaacgc atgggacagc 62220ctagagcagt
gacagaaatc tctagagggg aagacttcat cctcaggaaa aggagcctaa 62280gagtagagta
tggtgaaatg agggccccta cagcctgagg caccaaaatg ggggccttgt 62340ggcagaggaa
agaacacaga ccgccccagg gaaagaagac ctgtacctca gacccctctc 62400ttgggaacag
tcaatgcttg attatttgcc tgccgaacca cgttcccctg ctcccccaca 62460tgcacttctc
catgcttcta cttcttttct gtgcctgcac tgcactaggg tctctgctgt 62520gcaaatctcc
caaagggttg tcttttccat ccacttctcc agcaatggcc tggggtcaaa 62580tgttcctgat
gctgagctga aggacctcat ttagctgaat accttcccaa agagaatgcc 62640cagggtgagc
cctacattgg tctgagggta cctcacggtg ctcctcttct gcttgagggg 62700cctggcaagt
tgttctagtt ctttctgcag gactttgacg tcctgggact ccttgggact 62760ggattccacc
ttctccaact tcacagctct gaggtggaca gtacaggacc cagggaagag 62820atcctctcag
gtgctcccca ttctagctcc tgcatggcac tcaggcttca atctccaggc 62880caacttaggg
tattggtccc aggccaactt ggggttcaca atatgttatc cttccacagg 62940actcaatgga
aagatcccca acacctccaa acttggtcca acctctggtc cagttccagg 63000cccacttgga
gggcctaagg cgctcagcta tgtctcaggg catgcccagc ctggctctag 63060ccctcctaac
ttcatcagtc ccacctggta gggatgagaa ggtaaagtct aaagccaggt 63120gtctgaccat
ggggaagcat gggtacctca ggcagaggcc tgattactga gattcttgta 63180cacgtacaaa
gtggggtgag gcagcagaca gcgtgtactt acagatcctg tgcattccca 63240gtaagctgga
attttacaca ctacagtgtg ttcttcggtc tatggaagta tatggtgatt 63300acactgcttc
actaatgggt tggaacgtat ctcttgttac atgatctata taattcagta 63360gctgaagaga
ttaaacacta tcagccaggg atcatcctct gccatgtgct gtggactgaa 63420agttaggctg
cgcttccttc ctctatctgc tttattacag aatcgcacac atctgaaaca 63480tggaaactga
agggttaaaa gcgaataatc ccctcctttc cccagcctca ggtacatgat 63540gaggtttgca
tggatgcggg tcataaatcc attttggacg ttaaaaccgc tggaagatga 63600aagggttctc
atgtttttgg aacacactgt atttacatat acaaaggcat taaacgatac 63660atgggaaagg
ccctgtgtgg cacgactctg gtattctcta actgccagca ctctgaatgt 63720ttgcggcccc
agagaacctc ggatccctgt gggcaggagt cacgtttccc tttcccgctc 63780tgttgctgct
gagccacctg aacaagaagc ctttaaagac aatggacaag accccagctg 63840acccggcaga
tcctcagctc cagatgttgc ttttgcctgc aaatactgga gcctcactca 63900caacaaacac
tcactgaaga gagtctacgg aagacagctt tgttactgcc attagcatga 63960atttctaaat
tccacaacca ggaagaaaaa cccaactata tagtgaattt ttcttctctc 64020tagaaacaga
taaagaaaaa tgaaaagaca taaaaaacca tgaagtgtag aattacagct 64080gactcttctg
atagctatcc acatgcctac cctcacacca agggaccata ttcttcacca 64140gggctagcac
tagactagca gggacacata gacagcttat gtagtaagct atctgtagta 64200tcaactacta
aacacatatt gataggaagt ccctcaaaaa gcaaatataa tacaaatgaa 64260accagaactt
actcatcttc cacagtggac acagtttatt tgagatagga tcctactctg 64320tagtcttggc
tggcctcaaa ttcattatgt ggctaagggt agccttgaat tcccagcagt 64380tatcctgcct
ctgcattcaa gtgttaacag ttacccacag gaacagcttg ggtgtgctgg 64440atcccagtag
gcagaggcag gcaggactgg tctacatata gttccaggcc agccagaacc 64500atacagtgag
accctgcccc caatttcttt cttttataac tatttattta ttggggaggg 64560caacacatgt
atagtgtgtg catggagatc agagctttag agcacagtgg ccatnnnnnn 64620nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 64680nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnntcttta gtacgcattg gcaagctcca 64740tgtgctctaa
agaaggccca cgctaggcga cgaggggaat ccacttacat ggcacagtct 64800agaagatata
tagagtgcat tgtgaaagca agggacatac atgattctag agtgtaaaaa 64860tgatgtacac
tcacagacac acagaagaca cacacacaca cacacacaca cacacacaca 64920cattattatt
attatacgta tataactact aagaaagatc agtcaagcca ggtgtggcaa 64980caatgctatc
atcctagtac ctgggaggct gaggcagggg acatcttgtt tgaggccagc 65040tttgggccac
ctaggaagag actttgaaat cactaaaaat agacaaagca aacaaccctt 65100aaaagatctg
ttataatgtt ttgtttccta tacgcaaatc tttaaagtgg ttcccttaaa 65160aacaaaaaca
aatacaaaca aacaaggaac ccagcacagt tacttgcaac ttaataggga 65220aaaaaaggag
aggacaataa gactctatgc tggaggtaag agacagcttc acacagaggc 65280cagaatggaa
cggagagctt atacccagca tacttaggct gctggtgaga tccatggtgg 65340gggtggggga
aatctctgaa tagaaagtcc ctgactgaag acagcagtgt tccacagctg 65400cccaggaact
ggacgttcat cacaggcagg acactacatt ttaagcgatc ccgctctatc 65460agtacctgtt
gcctgacccc ccccattccc ttaagagggg cctaattatt ctaataatat 65520gttttagttg
ctaaacttga cctaattaaa gagctttgag gaggccgctc ttcttgagaa 65580acacaagagt
aactcttctg aagggctacc atcagaagct cagaagctca ctgggccatg 65640ccacccacta
attaaaatgc ccaagagaca ttcgtctggc agtaaacact aattaccaaa 65700acacatcaaa
gcttctcaaa caagacagaa tgattcattt tgtgatttcc aaaataaggg 65760attttctttc
atttaaaaaa aaaaaaaaaa aaaccttctt tacaaatgtc taagtacctt 65820atttttctaa
aatagttgga aaattctcaa acttgttata gagttcaggc tagtgtagtg 65880cagcctagtt
ctgttttatc tccacaatga cacattggtt gtccttggat aaaacattta 65940tactgccaac
agcctcacct ccccttgctc tgttaaatgg aagccaactg tcacaagcca 66000ggaccaatga
aaaagctcct gcatttgggg ataaacttgt actcttaaga gttaccatat 66060ataacaaatc
ttgaattttc aacatttaaa aatacactta ttacatgttc actcagcgcc 66120atggcgggga
agagttaaga attttgtgaa gagctccaag ctctccaaca gctgcctgtg 66180ctgctcagaa
ccctcatcac tctggggtcc gggcggaagg catcagtggc agcatactgg 66240gtagcctgga
atacgcacac cacccagaac tgcgactaca aacatccaca cactactgct 66300gtaactgtgg
gtgtagctgt ggctgtcact taagcagctg cggcacatca ggcttcccca 66360agtccagcac
ttgactctgc tgctcctcgc tgggctctgt gctcctctcc tccagctctg 66420tcttctgggc
tcatgtgcat tcacacctta gcctcagctt ttattttcat gcactgggct 66480ccccccaccc
attagtttgc tctcagtcta atatcaggtg ggtgtgccag gaaaccaatg 66540gcctgcagtt
tcattccctg tagaaacctg cctttcagtg gtctgctgac aaatggttgc 66600tttatgttcc
tacagactca gtgggcagga agcaaatatt caagtccaga tgggatattt 66660aacctctgag
ggagaaaccc agaacagtag ccagcctaca cttacacagt cagaggatct 66720gaatctacag
tggggcactt tcacacagtg aaacagtcaa agaaaagcag tctggacttc 66780agcaggattc
cagctagaag taacttcctc caggccattt ggtgagctag ctctcctgtg 66840tcttggctac
caatgccagc cctgatagag tctcaactgt acccagacct tggcttctga 66900tcagcttctg
attcttgccc ttccttccct cagcagacat caaggagaca cctgctatgt 66960aaagtctgcc
atgccgacct ttcccagcac taactggcag cttattgttg aaatgtggtg 67020ctgatttaag
tgttctttac tgtaacatgg ctccagccag ctaaaacaga aatgcatttc 67080cttccctttt
gaagtcttat caaaagtggg gcagaggatc tcttcccact taccagtcat 67140ggcaggtcac
ttgccatggg tcctcaggtg ctcgcccatg aagtctttca aacatcagtg 67200gcactctgag
gctcacatac cctctgaggg tgacagaata atgaatggag tctgcagttc 67260aaaaacacta
cagcactagc acacagacct gcctcagaat tcactctcac tctgtcccag 67320tctactgggg
caccaagtgg aggtgggata tgctgtggat attcaagttc gaacctttca 67380aagaataaaa
cacacaggcc agtttttgct tgcctagacc agcagcctca ctggcgtctt 67440agaggtatgc
cactaataga acagaggaag ggagctaaca tttcttaaaa taagtcactt 67500ttccactctg
tgcagactgt ctccttcttc agagctgatg gaaaccacgg caggtcaagc 67560aatgggcaaa
actgtttcct gagatggaag gtgagcgcag cctcacctct gctggtcttg 67620tgtggtggcc
tgaaaccatg tctgcccttg caaactaacc agagccagca accctttaga 67680gtgctacttg
gttctatcat ttgttcttcc tacagccctg gaaacaactt cctgtttatc 67740aagcaaatgc
ttctttccaa aagagccagg gtgaggccaa aataactcaa gctgcccgca 67800agcaggttaa
tgagagtgct cactttgctc tcctattgtc ctcagacgtg aaggtcaggg 67860tgccgcaggg
tagaggaagc aggcttggtg ctctgtttcc tggcagaaac acacagaggg 67920cttctgggcg
tgctaggggt tctttttaca gtctgtctag cttgccagtg gtccgtgttg 67980tacatttctt
ctcccagact cacaatccaa cacagcaacg caatctatga gctccacccc 68040ccaaaattcc
cagaagccag caacttctca cgctggtttc caccctgtct agcatcacca 68100attggggtga
acagccacca gatttcaaga tctcttgata acatgcctaa gtattatctc 68160caattctgcc
caaggctttc tgcatctgtt ctctaaacag tcacaagtca ctgggaagag 68220aatacaaaca
ggtccccagt accttcctca atggctaagt cttacacaat tagagaagag 68280aagcaaggcc
cagaatctga tatgggtgtg atatgtatcc gtgtcgtttt agcacacatg 68340cagatacaca
accttctcac tgtaatcagg atgcagaatt actgccagtt tttcttcctg 68400gggagttact
ccttggtgag aatgtctgca catgtgcaca caagtaagcc tgtcttactt 68460aactcctggc
tccaaaagat acagagatat tctactaccc caaagttctc cctactactc 68520tgtcatgttc
taacagatac agtgctcttg ccttaggacc gctgttctct cctgactttc 68580tcccagcaac
atgtgaactt tgatcgcatt acagccttct ccgagtcctc ccttgactgc 68640cctttgattt
tatcttagtg tgggtgttat actggcatgc ttctctgtgt atcacgtgtg 68700tgcctggtga
ccacagaagc cagaagaggg agtcagagcc tctagaacta gagtcacaga 68760aggtagtgag
aaaccacgtg gatgctaaga attgaactct ggtccccctt caagagcggc 68820aggggctgtt
aacaactgag ccaactctcc actgctcctc tggccccaga cttttcacac 68880tttatcatct
tctgactaat tacacatcta tgtagtttgt gtgttgtttg tctctcctac 68940taacaagtgt
caacagggat ttgtgtcttc tgtattcatc actgcttctt gtacttgtgc 69000actagctggc
acatgtgaag tacttgacat gtgtatgttg ttcagagaac agtggcatgg 69060gaaatgcaac
cagtacaaat gtggatgcag gacccaccca ccaacagagt tctgaccata 69120tattttttta
aactcacttt gccactaagc aggttttgta aactaagggc attttctgtt 69180ctttttaaat
acttttgata cctagcccat ttacatgatt acatgaagca tgactgattt 69240tcacagggct
ccgtatctct aaatccaaag gcctgtttgc ttgtgataag gcacctcctc 69300ctatcccaaa
agtcttttaa taaaatgtta attgtggttt cctgcagtag aaacagatgc 69360ctctcatact
gtcccagtgt atcagcacag gttggctagt ctgaatgatg cttctattct 69420tgagttccta
cacgtagaaa aaaatatcat gcggtgtgct tccgtttgtg taggaggaac 69480agaaaagcaa
tgttaaatga ataatgttaa tttaacatta aataaatatg actgcttacc 69540gaggtaggac
ttatccctct cctagtgttc tctcctttag atagggactg tttaactcta 69600aatctaagac
agagaatgtt caaggaaggt ctagaatctt gttcaaaggc aaaggagtta 69660ttgagaagtc
aactggatgt ggttccgaag tggaataatt tgagtagtga gagaataatg 69720acacaggaca
gggaggcagc tcagtgatag agaggagaga gaaagggaga agatggtgat 69780ggagaagaag
aagaaaacct cagtggacta aagcacacca gccacattcc agtccatgga 69840ctcacagaaa
agaaacaaac aactcaagtg ggtcccactg gacactatta gggtaccaac 69900ttgcttgaaa
tctgaccttg ctacaatctc tagttttttt aaagcaaagt tctttaaaac 69960tgataaatgt
agaaagcatg aaagaattag aaaactacca gtttgcaaca tttggggtga 70020actttgctct
gagacatggt cttcctgtgt aacccaagct gacctgaatc aagcttgcca 70080tggaaccttg
tctagacaca gactctgatg atcccatccc agcctcggca gtgtcaggac 70140tagaaggacg
tgctatttgg accaggcgtc actttgtatt ttagcatgga accatgtctc 70200taggtgacca
tgtgagagga gcagcttcaa aaactggcta aggtcagaaa gggattacag 70260ggacacagct
aaacctgcag gttatctgaa catcactaaa gtggaaacca gtcactatcc 70320aaaacttgaa
gtgaaccaat ggaagaggtg tgcagaatcc tgcctctcca ccagggaatt 70380ccacctacat
ttaagcaaac tgtaaccaca actggcactt tacgagaaag tgcgagagct 70440aagaggacat
gtttcatgat gagagacatg aacagccaaa tttagtactt acacatctta 70500caagacagtc
cagctttttt ctttaacatt tatttattta ttttatttat ataagtacac 70560tctagctgtc
ttcagacaca ccagaagagg gcatcagatc ccattgcaca tggttgtgag 70620ccatcaccat
gtggttgctg agaattgaac ttagaacctc tgaaagagta gttggtgctc 70680ttaaccactg
agccatctct ctagcccaac agcccagctt cttaagcaag agactacaaa 70740ggaaaaggaa
caaacaaaaa tgatgtggca agtggggaaa gaagggcttc cagattataa 70800agacatagta
agacaggcat gtatcaagcc caagcatgct gtaaacaggc ttcatgggcc 70860gttctggtgg
gagttgggat gaccaaatta ccacgacaaa cagaagatag tgaaggcctg 70920gctcccgagt
ttcagaggag aatgagaact agattagaaa ctgggctaaa ggccatttta 70980tgatatccta
gcaaggaatc tggctatttt ctccatgtgt tgagaactga gagaggctgg 71040acgtaagagc
aatggactaa ttcatctggt agaagaaacg taaatacaga atagcatgca 71100ggctgtgaca
tggctgcttc ttacagttct catccaggtc atctgtgagg gagtatcaaa 71160aggcaaagca
gaaagatatg aaattgtgca ctttgagagg aaaggagttg gagtttaacc 71220ttactaaaag
acagggctac aggattttta aagagattac agcaatctcc actgcaacta 71280caggagctag
gtatgcccta agggcaagac cttagacact ggagactcca ctgtataaac 71340ttgaaaattc
atttgaaaga agaaaccctc aacagagtaa gtcactgaag gaacccctcc 71400tcctcctgga
aaacagatcc ctagggatgt gtttcgccat tagtacacag agactgatac 71460aactgtggtc
cccagaggcc atgctccatc cactttgagc tggtagcaga cattgatgga 71520attagtcaca
caatactgag ttctcaggca tgagagacac gggactgtgg gggtccaaag 71580atttaagtca
cagttgaaga gtgttgctga ggccaggcca tgtgtggcaa gggagaggtt 71640cctgtaagaa
agtcctgaag gggcactggg tgaagctctg aacgtgaagc cagaatagca 71700atgaagagac
actgggaatg ccagggccat gggacaggca ctgaggaaag ctgcaggcac 71760ctggcagagc
cggccgggag agaagccgtg tgatagacag aactgttgaa gggctggggg 71820ttagccataa
cttgtggtac tcgggtggcc ccatcacaat ccccagatgc aggccacaga 71880gcttgaagac
ttggtgtttt tactgctagg ttttggtctt gctttgaccc aattgctctg 71940ttctatgctc
cattttcttc tttcaaaata tcaatgttta ctcagagctg ctgtgtattt 72000gacgtgggtg
atttgtttat gattttatag ggatttacag ttaggaggcc accttgagtc 72060ttctgtgact
ctaggacttt gggctttcca atatcgttaa aaagcccagg agacttcaga 72120agttggactg
aatattcaca ttgtagagag ccacgaacca agctaaggaa taaaaggtga 72180tggcttgaaa
gtgctatgtt gaaaggctct gggatcacct tggagacaaa tttctgggca 72240tatctgtaag
gaactttcta gattaagtta cataaaatgg gaagtccagc ctaaggacag 72300agggacccac
accagcattc cccagtgcct gcctaccaac tctgggacac tgtgacagtg 72360cctgtgctta
ctatgctccc tgccatgatc aaatgtaaat tggaataaac catcaagttg 72420cttcttgtcc
aggattttgt tacagaaaca agaaaagtag taacacagaa ggacaaaggg 72480gaagaaaact
ggaaagagca tcaaaattag caagaaggta ttcggatgca tacatgtaat 72540tgcaatcgtg
tggggtagag aggcaagagg attgcaagtt tgaggctatc ctgagctata 72600catttaaaat
ttaaaaatca gaatggcaat tctactcaga gccatggtca agcccctggc 72660tgtatgcaca
caacgttaac actcggaggt gggcttagca gagagcagca gccaggagtc 72720actcagaggt
tccacccaga agatcctgga gttctccttc aagttaaaaa gagcagcttt 72780gttgaatatt
ccagaaaact atccctctgg agtaagggct acataagagt aaggataaaa 72840tggaaaccac
aaactggagc tgcgacaggt tcagtttaat cacctgacag aaccaagtgc 72900tactgaaggc
aacaaccaca atcactgcag tgatcgcccc tcctgcccaa cacacagtaa 72960aaatgacaga
acggaaaaag cagaactggt aggatggttg gcaggcagag gtgcttgctg 73020tcaaggctgg
tattcacatg gtggaggggg gaactggtac ctacaagctg tcctctgatc 73080tccgtgtgtg
ctctggcaca cacacacaca acaaatgaaa caagtgtttc aaatagtctg 73140tgaaaacagg
ggcaaaaaga ctgagagacg tggatgaaca aagacttagc tatgattgct 73200ttgctaaaga
acactcacga aaaggagagc gaagggataa aaagagcctt taaggtaaga 73260cactcactaa
acctcgtcta aagctgcaaa atatcttaaa ccaagaagct actagaagct 73320gggtggggag
tacagcattt gggagcctga ggaagaagat taagtgttcc aggttagttg 73380gggctaacaa
ctagtgagac tgtctcaaaa acaaaagcaa aaagcaaaca gtattagtgc 73440tctttttttt
gttttgtttt gtttttccag acaggatttc tctgtatagc cctggatatc 73500ctagaactca
ctctgtagac attagtgccc ttaagaaagg tgttgtgatt aagctgttta 73560aaatccttta
cacataagaa aaactgtaag tatttatgac taaaaaaaaa tgttccttga 73620atttaacttg
aaatattcaa aactgaaact atagaacagt tggggaaaag aaacaacagc 73680accagcataa
tgctggcgat tgtcagccct gggtgttggg ggagcggggt ttaccacgag 73740acccttctcc
tgtacgtcta gttgaacatg cttacagtaa aaaggggttt tcactggtac 73800atcagtgctc
actagtatca gcatcaggac cgaagcatgg gaactcaagg gtccatcacc 73860agatgaacac
atgaaatgtg tcactgatga gtctgacaca tgaacatcat aagtgacata 73920agctggtccc
acaaggacaa atacggggtg attccattta tataagtccc taaagtagtt 73980aagctcaaaa
catcaggaag ggtgatgctt tgggggaact gtagggtggc agaatagtgg 74040ccagtgatta
acacctcgag tttccattct acagaatgca aagtttcaga tgacaggact 74100gcagtgtcat
tattaatgtt actgaaaatg gttaaaataa ttctgtgtac tgaatatttt 74160acaactttaa
aaaaatggaa tgctggctgg aatatcttca agacattttg aagatatact 74220gaaatgtgac
atattaattt caaataagaa attaaaaact gtagatatca ataaaggtta 74280taattaaata
tcttttcatg tctttattac tagaccaagg aaaactacat tttcctaaaa 74340gggttaaaac
atagtttgaa aaaactctca ggaaaagtgt gtatgtatac agatttatat 74400tgacacatac
acatgtatat ttatgtacac acacaaaaca gaaaaaaatt cctttcgaac 74460atacatatac
taaattcagc aaaaaatgtt tggcttgggt atgatgccag cactcagaag 74520acaaggggat
ggtgaactca atgtagaata ggctacacaa tgagacctta tctcaaaaac 74580cttccatgaa
aaaaataaat attttaaaaa cccacaaata gtgactgatg agactgtgca 74640agcatgagga
tccaagctca tatccttagc acccatgtaa aatgttgctt ttggtacatg 74700ccagtaatct
gaccccttgg aaggtggaga ctggaggatt cctgaagctc actaccagag 74760tcctactgaa
atcgtgagtt acaggtccaa tgagagactg tatttcaaaa ctatggtaga 74820gagaaagaaa
agcagccaac atcattctct ggcctcggcg tgcactgagc tcacatggta 74880caaataacat
cttgatcaga aaactgtcca tgacaggatc ccccatggag gagctagaga 74940aaggacccaa
ggagctgaag gggtttgcag ccccatagga ggaacaacaa tatggactaa 75000ccagtatccc
cagagctccc tgggactaaa ccaccaacca aagagaacac atggggggac 75060tcatggctcc
actgcatatg tagcagacaa tggccttatt gggcatcaat gggaggaaag 75120cccttggtcc
tgtgaagttc tgtgcccctg aataggggat gccagggcca ggagtgggag 75180tgaggngttg
gtgagctggg gagcaggtag ggggtggggt tctcagggtt acctaggagg 75240agagacnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 75300nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnntaaa cccctgtaga 75360gcattctccc
ctctcttcta catcctcttc ctccattact attacaatgc tgtgcntgtn 75420ttttgttngt
gtttggggtn ntnnnngggg ggcgtccatg tagtacatct attatgacca 75480tgattacgaa
ttatggccac tgtgctctaa aggtagtgtg tgtgtgtgta gtatgtgtgt 75540atgtgtgtgt
gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtatgcaggt atggacatgt 75600catgcatata
tgtggagatc agaggacaac tttgggaaag tcaggtctct ctcctcccac 75660catggttgca
ggacttaaac tcaaatcacc aagcttgtgc agcaaaatgc cctcccccca 75720ggaccgcctc
ccactcccca tttttttctt ttaagaaatt aagacccctt tgtcctctac 75780ttcatcttgt
gccttcttct ctatgctcag gtttaggctt attttttttt tttaatttaa 75840ttttgttttg
tttgagacag tttcgctgtg tagcccaggc tggccttgga atcacagtag 75900tcctcctgcc
tcagcctccc aaacactgga attataagtg ggtaccacta ccacattgac 75960ttaagcaatg
aacctcagag ctgtatgtgc taaaagggtt acggtgtgtg gatttttaaa 76020tctcggttta
caaagagaaa ccgagcagga gcagccactc cagtggcttg agcagaggct 76080aatccatggg
tagggctgac tcgcgagcct gggtgctttg ctcctgcctc actgatgatt 76140cctgaccttt
cttctcaggt cttctggaac acaatcgccc ttctgggaca tggagccgcc 76200ttccttcccc
aagaaacaat tcatcgttgt tctgctagca tcccaagaca tttgacaagc 76260ggcagcaact
gggctgaaag ctgagtctag gatgaggtag ttattttaaa gaccctgtgt 76320ttgttaactt
gccttcctcc ctcccgccct cctgcccccc ccccccctct tctctgtctc 76380tctctgcctc
tgtctctatc tttctccccc accccctcag ggattcacgt agcccaggct 76440ttcttcaaac
tccctaaata gtacaggaat cctcctgcct ctgcctccca agtgctgtaa 76500ttacagttgt
gtcccatcat gcctggaatt tctgtctgtg tgacagcgtc tcatactaca 76560gcccatgctg
gcctaggatt tacagcagtc ctgcctcagt ggagtgctgg gcttacaggc 76620ttctggtgtg
atttcccaga atttattcag gcagtccttt tctccaggtg ttccttttgt 76680gaggccaaat
tctggagctg acctgggaaa gcaggcagag agattatggg tccaagatgg 76740agctgagttg
ctgccatgcc tgggggtgac tggggctcac cgtcttacct gcttggcttt 76800tcttactcag
ttgagaatgt atttgtctca ggtttgatgc aactgttctg gggcttacaa 76860acttcactct
ttcagaaaac aagggcatgt atgctacctt cgtgttgact tgatcctcaa 76920atggctcctg
tgaacccagg gacagagtca gctgataaaa gacaaacccc cccctcctct 76980gcatcacagt
ctgagcccat ttcttagtta agaaatcaca ggactttatt ctgccccagg 77040taaaaatggg
ctctctaggg ctccatagat gatcagtggc taagagtggg tgtgtctttt 77100gcagaggaca
catgagcttg ggtcccagca cccacattga acagcttaca aaccatccaa 77160ctccggctcc
tgagaatcag gcgtctctga cctctgagat cacctgcatt caaatgtaca 77220tattcccaca
cagatacaga cacacacgca catggacaca cacataaata cacatacata 77280catatgtagt
aataataata ataattaata ataatagata taaaaatggg atctctagtg 77340cttagtaagc
aaggttagga aatagtcttg ttcaaaattg ctctgatggc aagtgagata 77400ttagcttagt
tggtaaggcc acctactacc tggtgatggg tgtagagaga tgattagtgg 77460ttaagagcac
aggctgccag ctcacaaatg tctgttactc cagttccagg ggatctgatg 77520cctcttctgg
cctccacagg caccaggcac acattgcaca gacataatac atgcaggcaa 77580aacacccatg
catataaaat aaaataatac agaaaatatg tatttgtttt taagattatg 77640cagttcctac
cgggagcttt tcgttacttc caaagcgccc ttgggactga gttctccagt 77700cttggaagat
ctgcttgctg gtcacttcag attgtaacct gccttggaag accccagctg 77760tgttgggggg
acacctattc ttcccttttt tctccaggag cttgagaggt ggcagagagg 77820gcatctggga
aagagtgaca gctttaacag cacttgtcag ctgggcagca cggagtggct 77880atggactaga
gaaagccaga aatgcgtttc tgcatttccc aagagaatca aaggggtggc 77940aggccccatt
gttctctttc ccctgacgga ggagttagga ccctaccctt cccagacagg 78000atatctctgt
gtagcctgac tgtcctggta ctcactctgt agaccaggct ggtgtcaaac 78060tcacggagat
ctgcctgcca aattctggct tttttttttt ttttaacagc atcttgtagc 78120ttaagccaat
ttgtagccaa ggaaggatga ctttgaactt ctgaccctcc tgcttccacc 78180ttccacgtgc
tgagtccaca gacactcacc actatacccg gtttttatag tactggaaat 78240ggaacctagg
gcttcacgct tattaagtaa acactgccat ttgagcccca gccctggtta 78300cctcttgacg
ggaaagcttg cgcactttac cctggctgtt gtagcatcat taaacttggc 78360agttctcttt
gtccccacaa aggctgtccc atgctttgtc tggctcttct catgatgtgc 78420atgggtcata
gaccaccaac cggattctgt tcccttctgc ctcgacacgt gctgtgcgga 78480ttggctgcac
agggaacaga agattctact gggggtgctc tccctccccg agccaaccca 78540ggtgacctga
acggaagggc cccgtgacgt gacgtgacgt gggcttgcct ccttgccctc 78600tgtttgtggg
tctgcctaaa tgaaacaata tattttcggg tactttcaag tgagaatttc 78660tttattgctt
ctctagaaag aaaaaaaaat taaatttatt ttatgttact ttttcgtatc 78720tctcagttct
catgctgtga tttagcaggg agagcgagtc acctgctgcc acaggttagg 78780agcacaggga
acacactgtc tcccctgacc cccagcacct aggggccgca ggttgagata 78840gggggtctgg
gggaaaggga gtttggaagt ttgtttggaa gtttgtggct tcttttgtca 78900ctagactcgt
gatcgggtca ctttgagatg gacatcacct cttcaatcta cagctgtggg 78960acacttgcaa
ggcacatggt agtgcccctg ggttcaaggt gggcttccta attgggtagg 79020gatgaggtaa
aggactgtca ggggccatag agggccatag caggtctaag atagtctgta 79080ctcccgtgag
accagtaagc ctgggtcttc ctagcttgca tgggggtggg ggtgggggac 79140actatgtctt
ccaggaatgc acaggggaca gggctgacct tgaatttagg atcctcactc 79200ccctaccagt
ttgtcctttc tcaaatctca ggtgacatca aaggtcaggt taaagttgaa 79260ctagagggaa
gtctaaaatt cctgaagaac acgccctttg ctctactaaa gagctgtttc 79320tctgagatga
cagatggggg acttcatata gtacctgcgc ctgggaaata ggcccctcct 79380ttccctactc
ccacccacac agccctgcct cctgggcatg agttcggtct cagctctgcc 79440tactcacatg
actccctgac tgctcttgtc tagaccaggg aagagggcat gactccacac 79500taggacttgg
gtgtcctggt cctggctgtc atactccaca tgtctcagct gtcctcttgg 79560tgttgctctt
ctgccctggg tgtgacctgg aagtattgtg tatgtagctg agggcggact 79620tgaacttctg
ctcttccttc gtctacctct caagcgttgg gattacaggt gttgcatcaa 79680tcaccatgcc
tgctttatgc aatgcccggt ctgtcatggc cctggtgggg acagaatgac 79740atggctcctg
cccctgggac agggccagca ggcatgggcc tccatgattg ttgatagctg 79800ctatgggcat
aaggcttatt tgtatgaata atgtacatat tttaccttcc tccagccagg 79860acaatcagag
acagcatgtg tctgcgaggc aaaggtgtgg ctagtgtcag caaaatggta 79920aacactggga
ccttcaagac agcccttaag gctgggttca aaaacatata acttctcaaa 79980aaataaggat
gcaatatata tgaggggctt catgaatcta aagaaccaaa agcgggtgtg 80040ctgtgagctg
gcttgtcaga aaaagagatc ctaagatgga gaaagagaga ttagggagtg 80100gtgagcacag
gaggttccac ccagtacatt ttttggtttg tgcttacaag ggcagacaga 80160ttcctgagtt
caagctcagc ctgggacaga gctaatttag acccaagtgt agtagaaaag 80220gtaatttcag
gatgggttcc cacccaacta gtttatgctg gtctgtgatt agcagaggcg 80280ggcaggtctc
tgaattcttt cgaaatgtta aaagaaaatg tgtgcttgcc atctcctaag 80340aacttagggg
ccggggttat gggatactgg ttcataggat aatcaaatgg aacctgggta 80400aataactggg
ttgatatgta aaataaaaga ctgggcttag gatctgcaag agaggagcta 80460tctggagaat
gttttagaat agcaagagaa agaactgtct gcagcaacaa agagaggtag 80520cagcagcagc
agcagcagag agagagagag agagagagag agagagagag agagagaaac 80580ctgtctggag
atctccagag aaagcagatc agagagagag gaagcggact agagagaaag 80640caggctggag
agctgtcttg agcagaacat atctgctagc ttcttcctac aatctgactt 80700cttgagtcac
tttcaccact cccagacacc ccttctctca ggaccccctc caagccaagg 80760ctggtccttg
gcaaggcaat aatggacttc acgaatgcta gacaatcaat ctgtccacta 80820agctacatcc
gagcctcagt cagccccttc attttagatt tacttattta ttttatgtat 80880atgagtatac
tgtagctagc tgtcttcaga cacaccagaa gagggcattg gattccatta 80940cagatggttg
tgagccatct gtaatggtgt gtgtgggtgc tgggatttga actcaagact 81000tctggaagag
cagttagagc tcttaaccgc tgagccatct ctccagccca gcccctccct 81060tcattttaaa
agcctggacc gcagggtcaa aacaagaagg agggaaggca gaggagggac 81120ggtaggcagt
ttggcaccct gcagagtgat cctggctagc cccttggagc ctggcaatgc 81180ctgaaggagt
gtgctgaagg ggaggaacca agcgtgcgct ctgtgttgta ttctactggg 81240ttggtggccc
caccactggg atctgactgg gacagagatg ctcctgcatg ggactcaaca 81300agggctctgg
ggacaagggg ctcagacttc cctttatgtt caatgccatc ttccacccca 81360cccccaccca
taagtcctac ctgaatggga aagctcagcc tcagggtttg tcacggtcca 81420gggcttgaac
cactctctct ggtttttgct gaatggcatc cccccaggct tgtggcactg 81480gctgtgtaca
ctggaactca tgctccctaa tggagcctcc tcgagcagct gcaggcggta 81540tttcacgtct
gttggggaga tttcctcctc ttccagatcc tcagggacag ctctgtgctg 81600ctgctgctgc
tcctgctgct gctgggaggt tcactcggtc agaggggcca ttactgggtt 81660aagtagggga
agtgagtgtg gatgtgtgtg tgtgatgggg agagaagtct cctaaacact 81720tgccagtgtc
ccctagaaag ttacttgtct gagctacaat gtccttactt gcaaagtcaa 81780taaaatatgc
ccgctttctg ggttccctag gagagcagag ctaagggctt agcattatgc 81840ttggcctgag
taagtggcta atcgtctctt tctcttaaaa tatttatgat cctgccagac 81900agtgctgcgt
tggtggcaca cggggagact tggttggagc ccttagcttt acctgaccac 81960tggaggcgct
gtcctcaagt ccagtgggaa cagccaggga ctctcgctgg atggaattgg 82020ataaagagtc
atcaagcaag aaggatcttc tgggtccagg agagagaatc tctagagtag 82080ggaaaagaac
tgaggaccat ctcagccctc ctgcctgtgg gccgctttta gctctccatc 82140accctcccag
gggaaagcaa ggaagggagg ggcaatgtcc agatgggtcc agttttaatt 82200tatttgagat
tagattagtc tgagacctgg agtggaaggg ttagagtgga atggggctgg 82260ctctctgcat
ttaggggcac atggcaaagg caaccttcct tccttcctcc cttccttctt 82320tccttccttc
cctctttcct ccatccttcc ttcctccctc catccccatc tgtcttctac 82380tcttcctcct
ccctccctcc ctccctccct gccttccttc ttttttgaga gacccataga 82440acccaacgat
agctaggccg taactatcta cataactaca tgcagtccat gattaattga 82500gcctcctgtc
tgtgccgccc gaccgaggga acgacacgac aggcgctgat gcattcatag 82560atgtaaaccc
gaacgccctg caagctaggc acttacgttc aagacctaca tacctaccta 82620cctacataca
cagatataca atccaatcat tggattggtt ctttctttcc aactagcctc 82680cctttaactg
tgggcattga ttaacctacg acaatacaag atggatcctt tgtcccctgc 82740taggccaatc
aaaaacaccc tgtccacaaa ctttgaaaga ataacagaag ccaccccttc 82800tttttctagc
gggcgaaaag aacaaaaaaa ccaccccaac gctttcggtt cctttccttt 82860ttttggctcg
gagcccgcaa tacctcccca atcacccctt ctagaaagcc cctcctgggt 82920cttccctaac
tgccctggaa agcaaatgaa agggagcgct cgggctggga acataatnnn 82980nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 83040nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnaat atagacgatc tttatgacca 83100tgattacgaa
ttatggccac tgtgctgtgg agccaatccc agcatgggtc gggtgtctat 83160aaggaaaggg
tcacagagac accatgtgaa tacacctgag aggtagccag gttatgctcg 83220caggattaaa
acagactaat aaatgctcag atactgtacc ataaagtata gctgggttaa 83280gtaaatctct
ctctctctct tttttttttt tgtttttggt ttttggtttt tcgagacacc 83340acccggcggt
ggttaaataa atcttatagt ctctgtctca tttatttaga agttggctgg 83400gacagataaa
aattatccct tttaaaactg aactaacaac tgggaaatgt tatcttaagt 83460aagtgagagc
attcctagta agtcattcac acttcagcag cttcctctta aattagcact 83520ttgtcttcaa
tgcctatggg ttttgctggc atccaggaag cttttgatca agtgctgggt 83580ttaagagcac
atgataggaa gtttgaggga atatatctca agaaattata ttgggggagt 83640tttgaattat
gaatttagtg atttgccaaa cttactagct tctcaattct attggaacat 83700taggcagagc
cacactgtca tggctgccct tttacaacgc agtgctaagc cgcaatattc 83760atttcaccga
gtcagctaat agagcaaaca acacgcatgc agtgatgcac tccacttctt 83820ccaggtcaaa
cttcccatct gcttcctttt ctctatacac tcaaatagca aagataaaca 83880tgtttctccc
ctaagtcaaa acctcacaca actaaaataa gtgagcagga gaaatggcca 83940ttcattctct
gcttgacttg gaatatgtgc gtgctgtgct ggacaccaca ttaaacaata 84000agagcaggtc
acagctgtaa tgccatctgt ccatcagtcc attttcattc cctccttctt 84060tcattcagct
gatctataaa tagttagtgc ctatgcagtt tctgtgggaa ctattctgag 84120aattggcaag
caccaaaaat tacaaaatcc tggcttggga tatggttcag tatctcttgc 84180ctatcatgtg
taagggcaat gttgactctc tagaaccaaa aatacaagac aaactcttta 84240ctgtcaagat
gtactttggt aaggtcagat gtaaacaagt gagggccagt tagatggctc 84300agcaggttag
gaaacatgat gacctgcgtt cagtccctgg aacccatatg aagacagggg 84360aggagaaatt
ccataaagtt gtccaatgac ttcaatgtgg atgcatggca tgcacacaga 84420gcataaaaat
gctacacact aatgagtgac tgagtatatg tcaattggtt ataaagacta 84480ataagaaaag
taaagaaaaa aatgagatac agaatagtaa gccagtagga aaaataaagt 84540ttagttaaag
ttgtctcaaa tgaggaaatg caggaaagat tctcaagtaa gtggaacaaa 84600gatgtgggac
gagagttgca gaaagaaatg ggacaatatc tagaccttac agtggaggac 84660agaggacagc
caaatgtgga aggagcagga gagcattggg agctacagtt ggagacaggg 84720ttgtgtgttt
taagccctcg taagacactt ggtgagcgag gcacaagagc tgggtgagat 84780ggcagcacta
gcacgatgtc cagagtggtt cagtctccgg tcccctaggc aaggtcagca 84840taaacacagc
tactgagacc taccaggcag cttccttcca tcccagcatc tgcggagctt 84900tcctctgagc
tcagcacccc tcctatggcc atgctgtaga gctgtgctgc tagaagctag 84960cagcttctct
tgctaggctg cctctgccac cgaactccag tgcagacaga ctgtccttca 85020tcggaaatgc
ttgggatcag tatttccaat ttcagggttt agttttattt tgaacactca 85080tataaatttt
accagatagt tctcatctaa aaccccccag aataaaaaat gtttcaaaaa 85140acaaaacaaa
acaaaacccc aaatcatatt ggcattcaaa agcttctgat ttgaaagcat 85200ttcccagtgc
aggctcctgg tcaggcattc cccatgtgaa gcacgggctc atcaccgctt 85260ctagatcagc
gacatagaag cacatctgca taactgccag caactacaga ggaaagcaag 85320cagtaccact
cactctgcgc ttgatctcag caacttatcc agcacatttc acaccgggaa 85380cgatagagaa
atcagcagtg agacttgctc ttctctgctt ttcaagcaca ctacgtctta 85440gaagtccaga
gtctacacat ggcacactac caattaaaca ctgaactgac tgactatggc 85500caaagtaaaa
tacttttagt tctttcaaaa tagggtgcaa ttaaatatga aagcactgta 85560cagtatggaa
tcagaatgtg gccttgcccg gagaaaagat ctaacctccc cttggctttg 85620tggtggggtc
tttattagcc tggagcctca gtcgtgttag aaggtctaat aataatgtag 85680gaacactagg
aagaccaacc atatgaaatt aagcttggga ctctgggaca tcatgtcaat 85740tgtcctgaaa
attgaggtca acagtatgga caatcaatca atcaatcaac caaccaacca 85800accaaccaat
aaggcacaca taaaataaaa atgtggatgc aaaggctgag cctccctgta 85860acaatattct
gtgcatattg tcacacactc atcccaagac aaagcacacc caggcaaagg 85920acaatgaaga
ctctgcaccc agcacttgtg ggcctgccgg ctttacaccg cccttggctg 85980gtttcaccga
catcctctcc ctggaagagg gcacagcagt gagttctgag agtcttccag 86040cagtttatca
cacccgaatg gctctggggg atttctcaac ttacacttgg tgccagagtg 86100cgagtgatct
tggagaaagt gctttctcta tggcagctca cccctgcccc agcaaaataa 86160aaaatctctt
gtacaatgct ctggctgcca ttcaaatgcc actgtaaact aacctaaatt 86220cacagttcag
ttccacagct gaccttgctc catttccaaa gagcaacagc agcgtgtgaa 86280cagcagctca
catgctggga gccatattcc tggactttat ctggccttct ggttcccaac 86340acacttggtt
ttcaatttca cgtagacctc cagcctttcc tattctaatg cgtgatcatt 86400taaactggtc
atacttgtat aactactgcc gctgaagcac agacatcaca agaaaaaaac 86460atacatgtct
tcttttaaaa tcacaaaatt cctcctttga ccccatcggt tctccttgtg 86520atgtacctat
ttgtgggcct ttgtatttag gctacatttg aaagtccttg aggtttttgg 86580acatgtgagt
tactattttt tcaaaatgtc tgctattttc atagccattt tttcttacag 86640tttctgcctc
tgtctctaca ccctcctaat actgtcactg tgcacggaat atgctctgtc 86700tcctacagtg
cagaggatac tctgcctgtc tcctcccact gtgcacagga tgctcctgac 86760tgtctcctcc
cactgtgcac aggatgctcc tgactgtctc ctcccactgt gcacaggatg 86820ctcctgactg
tctcctccca cagtgcacag gatgctcctg actgtctcct cccactgtgc 86880acaggatgct
cctgactgtc tcctcccact gtgcacagga tgctcctgac tgtctcctcc 86940cactgtgcac
aggatgctcc tgactgtctc ctcccactgt gcacaggatg ctcctgactg 87000tctcctccca
ctgtgcacag gatgctcctg actgtctcct ctcactgtgc acaggatgct 87060cctgactgtc
tcctcccact gtgcacagga tgctcctgac tgtctcctcc cactgtgcac 87120aggatgctcc
tgactgtctc ctcccactgt gcacaggatg ctcctgactg tctcctccca 87180ctgtgcacag
gatgctcctg actgtctcct cccactgtgc acaggatgct cctgactgtc 87240tcctcccact
gtgcagagga tgctcctgac tgtctcctcc cactgtgcag aggatgctcc 87300tgactgtctc
ctcccactgt gcagaggatg ctcctgactg tctcctccca ctgtgcagag 87360gatgctcctg
actgtctcct cccactgtgc acagaggatg cgccttacag tctcctccca 87420ctgtgcacag
gatgctcctg actgtctcct cccactgtgc acaggatgct cctgactgtc 87480tcctcccact
gtgcacagag gatgctcctg actgtctcct cccactgtgc acaggatgct 87540cctgactgtc
tcctcccact gtgcacagga tgctcctgat tgtctcctcc cactgtgcac 87600aggatgctcc
tgactgtctc ctcccactgt gcacaggatg ctcctgactg tctcctccca 87660ctgtgcacag
gatgctcctg actgtctcct cccactgtgc ataggatgct cctgactgtc 87720tcctcccact
gtgcacagga tgctcctgac tgtctcctcc cactgtgcac aggatgctcc 87780tgactgtctc
ctcccactgt gcacaggatg ctcctaactg tctcctccca ctgtgcacag 87840gatgctcctg
actgtctcct cccactgtgc acaggatgct cctatctgtc tcctcccact 87900gtgcacagga
tgctcctgac tgtctcctcc cactgtgcac aggatgctcc tgactgtctc 87960ctcccactgt
gcacaggatg ctcctgactg tctcctccca ctgtgcacag gatgctcctg 88020actgtctcct
cccactgtgc acaggatgct cctgactgtc tcctcccact gtgcacagga 88080tgctcctgac
tgtctcctcc cactgtgcac aggatgctcc tgactgtctc ctcccactgt 88140gcacaggatg
ctcctgactg tctcctccca ctgtgcacag gatgctcctg actgtctcct 88200cccactgtgc
acaggatgct cctgactgtc tcctcccact gtgcacagga tgctcctgac 88260tgtctcctcc
cactgtgcac aggatgctcc tgactgtctc ctcccactgt gcacaggatg 88320ctcctgactg
tctcctccca ctgtgcacag gatgctcctg actgtctcct cccactgtgc 88380acaagatgct
cctgactgtg tcctcccact gtgcacagga tgctcctgac tgtgtcctcc 88440cactgtgcac
aggatgctcc tgactttatc ctcccactgt gcacaggatg ctcactgtct 88500atctcctcac
gctctgcgca caggatgctc ctgattgtct cctcccactg tgcacaggat 88560gctcctgact
gtctcctccc actgtgcaca ggatgctcct gactgtctcc tcccactgtg 88620cacaggatgc
tcctgacttt ctcctcccac tgtgcacagg atgctcctgt ctgtctcctc 88680ccgctgtgca
ctggatgctc aagataaaat cctcccactg tgcacaggat gctcctgact 88740gtctcctccc
actgtgcaca gaatgctctt gactgtctct tccaatggcc cagggatgct 88800cctgactgtc
tcctcccact ggccaaagaa tgtccctgac tgtctcctcc cactgtgcac 88860aggatgctcc
tgactgtctc ctcccactgt gcacaggatg ctcctgactg tctcctccca 88920ctgtgcacag
gatgctcctg actgtctcct cccactgtgc acaggatgct cctgactgtc 88980tcctcccact
gtgcacagga tgctcctgac tgtctcctcc cactgtgcac aggatgctcc 89040tgactgtctc
ctcccactgt gcacaggatg ctcctgactg tctcctccca ctgtgcacag 89100gatgctcctg
actgtctcct cccactgtgc acaggatgct cctgactgtc tcctcccact 89160gtgcacagga
tgctcctgac tgtctcctcc cactgtgcac aggatgctcc tgactgtctc 89220ctcccactgt
gcacaggatg ctcctgactg tctcctccca ctgtgcacag gatgctcctg 89280actgtctcct
cccactgtgc acaggatgct cctgactgtc tcctcccact gtgcacagga 89340tgctcctgac
tgtctcctcc cactgtgcac aggatgctcc tgactgtctc ctcccactgt 89400gcacaggatg
ctcctgactg tctcctccca ctgtgcacag gatgctcctg actgtctcct 89460cccactgtgc
acaggatgct cctgactgtc tcctcccact gtgcacagga tgctcctgac 89520tgtctcctcc
cactgtgcac aggatgctcc tgactgtctc ctcccactgt gcacaggatg 89580ctcctgactg
tctcctccca ctgtgcacag gatgctcctg actgtctcct cccactgtgc 89640acaggatgct
cctgactgtc tcctcccact gtgcacagga tgctcctgac tgtctcctcc 89700cactgtgcac
aggatgctcc tgactgtctc ctcccactgt gcacaggatg ctcctgactg 89760tctcctccca
ctgtgcacag gatgctcctg actgtctcct cccactgtgc acaggatgct 89820cctgactgtc
tcctcccact gtgcacagga tgctcctgac tgtctcctcc cactgtgcac 89880aggatgctcc
tgactgtctc ctcccactgt gcacaggatg ctcctgactg tttcctccca 89940ctgtgcacag
gatgctcctg actgtctcct cccactgtgc acaggatgct cctgactgtc 90000tcctcccact
gtgcacagag gatgctcctt acagtctcct cccactgtgc acaggatgct 90060cctgactgtc
tcctcccact gtgcacagga tgctcctgac tgtctcctcc cactgtgcac 90120aggatgctcc
tgactgtctc ctcccactgt gcacaggatg ctcctgactg tctcctccca 90180ctgtgcacag
gatgctcctg actgtctcct cccactgtgc acaggatgct cctgactgtc 90240tcctcccact
gtgcacagga tgctcctgac tgtctcctcc cactgtgcac aggatgctcc 90300tgactgtctc
ctcccactgt gcacaggatg ctcctgactg tctcctccca ctgtgcacag 90360gatgctcctg
actgtctcct cccactgtgc acaggatgct cctgactgtc tcctcccact 90420gtgcacagga
tgctcctgac tgtctcctcc cactgtgcac aggatgctcc tgactgtctc 90480ctcccactgt
gcacaggatg ctcctgactg tctcctccca ctgtgcacag gatgctcctg 90540actgtctcct
cccactgtgc acaggatgct cctgtctgtc tcctcccact gtgcacagga 90600tgctcctgtc
tgtctcctcc cactgtgcac aggatgctcc tgattgtctc ctcccactgt 90660gcacaggatg
ctcctgactg tctcctccca ctgtgcacag gatgctcctg actgtctcct 90720cccactgtgc
acaggatgct cctgactgtc tcctcccact gtgcacagga tgctcctgac 90780tgtctcctcc
cactgtgcac aggatgctcc tgtctgtctc ctcccactgt gcacaggatg 90840ctcctgactg
tctcctccca ctgtgcacag gatgctcctg actgtctcct cccactgtgc 90900acaggatgct
cctgactgtc tcctcccact gtgcacagga tgctcctgac tgtctcctcc 90960cactgtgcac
aggatgctcc tgactgtctc ctcccactgt gcacaggatg ctcctgactg 91020tctcctccca
ctgtgcacag gatgctcctg actgtctcct cccactgtgc acaggatgct 91080cctgactgtc
tcctcccact gtgcacagag gatgctcctt acagtctcct cccactgtgc 91140acaggatgct
cctgactgtc tcctcccact gtgcacagga tgctcctgac tgtctcctcc 91200cactgtgcac
aggatgctcc tgactgtctc ctcccactgt gcacaggatg ctcctgtctg 91260tctcctccca
ctgtgcacag gatgctcctg attgtctcct cccactgtgc acaggatgct 91320cctgactgtc
tcctcccact gtgcacagga tgctcctgac tgtctcctcc cactgtgcac 91380aggatgctcc
tgactgtctc ctcccactgt gcacaggatg ctcctgactg tctcctccca 91440ctgtgcacag
gatgctcctt acagtctcct cccactgtgc agaggatgtt cctgattgtc 91500tcctcccact
gtgcagagga tgctcctgac tgtctcctct cactgtgcac aggatgctcc 91560tgactgtctc
ctcccactgt gcagaggatg ctcctgactg tctcctctca ctgtgcacag 91620aggatgctcc
tgactgtctc ctcccactgt gcacaggatg ctcctgactg tctcctccca 91680ctgtgcacag
gatgctcctg actgtctcct cccactgtgc agaggatgct cctgactgtc 91740tcctctcact
gtgcacagag gatgctcctt acagtctcct cccactgtgc agaggatgtt 91800cctgattgtc
tcctctcact gtgcacagga atctcctgac tgacaccaac tctggaagct 91860gcctttagtt
ccttcttctc atctctgtac ttgagtgtgg caatcttact gatctatcct 91920tgagtttgtg
tttcttcttt caggcagttc aactctgttg cggagacttt ctaatgattt 91980acttatttcc
cagcccaata attttttaaa acaatgtctc ctgttgatat tctttatctg 92040aagtgacatt
atgattcctg cctttaccgt tgttgcttca ctggtgagcc cctctgtgtc 92100tgtgatcatc
tttatgtttt cttctggtaa atctggcatc atctacctgc ctattatcat 92160tttcttgtgg
tctgcatctt gtggtccagt aactgggagt gcttttgttg tttgggggtc 92220ctgttgcttt
ggctgaacac tgggtgttct agatgacaga ctggggtacc tgaggtttct 92280gatatacctc
ccacctcaaa gcttctgtct gctttgttcc ttttcaacac ttggattgac 92340tccatccata
ttcttaggat ttgggtcctc tcttctgggc aaaacagcct ggcaaattct 92400gggatctccc
tagtttgaac tgaagtctct acacctcttt tcttagccaa acacagccat 92460tcaactccat
taattcttag ctgattgccc actgtgttgt tcgtggatgc gagttgtttt 92520acaaacaata
tagcaaatgt tggtcccttt gaaggaatgc tttctgatca gtgctttatt 92580tgtttgttag
ttttttttaa taacttctga ctcaggagag ctctttccag aggtgtcgtc 92640tgagggactc
tgctgtaggc catcaggctg ggggcagaga cggcttcgtg gatctaactc 92700cttaggtgcc
tctcagcaca tcctctactt gaccttcttt tccacttgta catgaacgca 92760ggccctttga
gaagacactg ggatctacct gtgtgcatta aggtctgttt ttctctctaa 92820tggctggagc
tagatagagt cgaaggcaac ttgtgagcaa caatcaaact ctgggagcag 92880aagtgcaatg
aaaagaaatg ggaagatggc ctgacatcac ctcagcccaa ctggcagaaa 92940accagtctta
tgtatgaccc aagccaagag tgatgtgctt ctccaaacag aagggagact 93000ccacttcaac
tacactcttc aggacacagc ctccccaaca ggtaacagga aagatgataa 93060atattaatga
gatgacaaat ctcattaatc tactcttccc gggaagacag ccacctctcc 93120agatgccagt
actaagaaga cctcgatgta tgtccagatt ggaatctgtc tctacctcac 93180ccagcctgtg
tgcacatgag gagggcatgg gagagtcaga gaggctgtgg tgccatgcat 93240agggctggct
caagaatcta gaccctcatt gcttactgaa ttttcataga tgttcttgaa 93300taactgtttt
ctttctttca ctgctgcttg ctcacaggat cagtctgtag atcaattctc 93360atcagttcta
catggcagct gataagacgt ctgcgtgact cctgccgaaa attgtccacc 93420atttcttctt
tttgtttgtt ttagggcttt gtttggttgg ttgatttttt tttttttggt 93480ttggttttct
ggtttttgtt ttgtttgttt gtttgttttg agatagggtt tctctgcgca 93540gccctggctg
ttttgaacac tcccgtttgt tctttaacat gaaggcaaag ggaagcatat 93600gccaaagctc
tctatgctga ctcactacac tcacaccctt cacccaaaac tggaggtcaa 93660acctagggac
ttacaggggg ctggacttga aatatccata gcatgagccc tagtccatct 93720tcacaactgt
agaccttatt ctagaggccc tgggactgag tccaagaatg actgggttac 93780ttgcctccag
cagagggtct atggatgaac ctatccatcc ctgcactacg ccaggcctca 93840caaccacctc
cccaggccca cattaacctt tgctgaaatg gaatccaggg tctcatgcat 93900gctaggcaag
catattatca ctgaactccg cctccacccc tcagcacctc ccttcttgac 93960taagtgcctc
ttctcttatc gtgtacacag acactttaga aaatcagtgc cacacgagac 94020agcttatcct
tgtgcagtct cgttgtccgt ctgatttggg gtttgatttg atagtaacca 94080aacccaggcc
ttggcacaag ttaggtaagc tattctgtca cagagctcct ccacaaatct 94140gtgtgaggtt
ttagtaattt ctttgggtaa tatgtaattt cttctcttca actggatcat 94200taaaaagtct
actatgggcc aaggagatag atggctcagt aggtaaaaga gcttgccctg 94260atggcctgat
ggtcagagtt cagatccccc atgtgatagt ctccgtgtct ctacactgag 94320atgggagaca
ggagaatcac ccacaaggtt atgggacagc tagcctggta tagacagtga 94380agtcgtagaa
acaagaaaca cttggccaca aaacaaggtg gaaggcaaga agcaactcct 94440acaagttgta
ctctgatctt cacacacgtg tcctggcatg caaactccta catgcacaca 94500gcaatattaa
tcatgtcaat taacaatata ttcactcata taattatatg ctaggttgta 94560atagataatt
gtgtgatatt ccctttttaa aaaataccaa aactgtgttc tgtgtactca 94620tgctacatat
gcattaagct acatatacac aaagggttta tgaccaaaaa ggactgttat 94680ctttcctttt
aagatctgtt ttcttgccag gcatggtggc acatgccttt aatcccagca 94740ctcaggaagc
aaaggcaggt ggactgctat gaatttgagg tcagcctagt ctacagagtg 94800agttccaaga
cagacagcca aggctacaca gagaagtcct gtcttgaaaa gaaatcaact 94860agaaaagggc
agtgttccca aagcaggaca catgcactgt gcttgcttag agtgtcagga 94920acattaagat
gagccagcct ctgttattct aaggatatca gtgcccctct gtgaacaaag 94980gccttactat
gacttagcta acaggcagtt cgtggatcag atgctgtgct tcctttcagg 95040acaaagttca
taaaaggtgt taggtaacaa aagttgccca ctggttttgt gtgcatttgt 95100gacccaatgt
gaagcagtat cagtgaacca accgtgtgcc tgggtgtcag gcctccatgt 95160attccccagt
ggcatcaggc aacttctctc tcccagtctc tggcattctt ctattctcca 95220ctctgtggac
tcattaaacc aggaagatgt ctgtgctctc tatagcactg ctatactccg 95280gtacggactt
cacagcctgc attctcctag tctaagatac acatagattt ccatgattgc 95340cttctattag
atttcttcat ggaggaaaat cagtgtcttg atatggaacc attacctcca 95400aagttactga
ttggcttgta attatcatat gtactaaaag cctacactat tgtcttgata 95460tacaatatta
ttctgagatt ttaatgcact aatttctttg aaatgaagtg tttctttaaa 95520cactgtatag
tgtaaaataa gcataaacac cgccgtttaa aggtaagagg aagaaacact 95580tggtcctcta
ttaaaggggg gaaatagcag tgacaatgat acttttcctg taaaaagttg 95640atggtttttt
tttttgttgt tttttttctt tttttgagac aggatctctc caggtagcaa 95700tagctgatct
ggaactcact attgacatca ggctgattca gaattcacaa gatttctctg 95760cctctacatg
cagagtgtta gaattaaagg tatgcatcac catgtctggc ctagcctaca 95820aattcaccca
ccaccaccac atcacatagc tattaattaa aaaataatgt tcactttaaa 95880agtgggaagc
cctcctgaga gtctatagga gtaatgccag ctaagaatcc tagcaactgg 95940agatataaag
actgaagtag ccacctccta tagccagaca ggacatccag tggaagaaga 96000aggacatcaa
tccacccaca aaaccttcca cccaaaatct gtctgcctac aagatgtgca 96060gggataaaga
tggagcagag accgagggaa cagccaacca atgactggtc caagatgaga 96120cccatcccat
gggagagagc caaccctgac gctattaatg atcctctgct gtgcttgcag 96180acaggagcct
agcataactg tctcctgaga ggtttcatcc agcagtgcat tgagacaaac 96240gcagagaccc
acagccaaac atcaggcaga gctttgggag ttctgtggaa gagtgcggga 96300taggattgag
tgtgcgggag cagtcaagga caccacaaga agacctacag agtcaactaa 96360cctgagccca
tggaagctaa cagagactga accactaaca aagaacatgc atgggccagc 96420ataggtgccc
tacacattta tagcagacgt gcagctttgt cgtcatgtgg ctcccctaac 96480aactatgtca
gggctatctc tgactgagct gcctgccatt ggaaccctcc ccttcctcta 96540gctgaactgc
caggttgcac ctcaatggga gaggacacac acattcctgc ttctacttgg 96600tgtcccaggg
cagggccgta tacaaggggg gcttcccctt aggagaagag gaagggataa 96660taggaagagg
aacttatgag ggttagaagg gggctggggg gctgtgatca ggatataaaa 96720tgaatacata
cattaatgag aaaagtgata ttatacttct aaagtgttgt aaattaatac 96780tggttctttt
agaatacagg agtttaagtt tgccaatctg cctttcacct ctatttggcc 96840gtgttaattg
ctgtcagcac agagaattcc gcgnnnnnnn nnnnnnnnnn nnnnnnnnnn 96900nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 96960nnnnnnnnnn
nnnctccatg tgctctaaag gcctctctac ctaactctct aactctctct 97020ctgcctctct
gactctctct gcctctctga ctctctgcct ctctctctgc ctctctgcct 97080ctctgcccct
ctgcctctct ctctgcctct ctgcctctct ctctctgcct ctctgcctct 97140ctctctgcct
ctctgcctct ctgcccctct ctctgcctct ctctctgcct ctctgcctct 97200ctctctctgc
ctctctctct ctgcctctct ctgcctctct tgcctctctt gcctctgctc 97260ctctgcccct
ctgcccctct gcctctctct gcctctctgc ctctctgcct ctgcctctgc 97320ctcctctgcc
tcctctgcct cctctggcct ctgcctctgc ctctaagtgc taggattaaa 97380ggagtgggcc
accatgtcag actatgagcc agccttcaaa tcccagtcaa acctggcccc 97440ctctctgctc
actgctataa acctctctcc tcagtcctac ccaaccaggg cctcagtctt 97500ccacaggagc
gcttatattg taatgtgccc gactcttcct ggcacagtgc ctggcacaca 97560gaaaactcaa
aattaactta gcatcaagag aagaaatgag atgtcctgtc acgttctgga 97620tgcagaaact
gcagtcggac aaagatgctt ggtttcccca aggccactcc tgcccagtgc 97680cagaggcaag
gccagagaat gatccagttg tgatccctgc tctggattct ctcactgacc 97740ccatagctac
ctaccaccac taaatcatag tgctccatat tggtaacttt tgttattctt 97800ggttagttca
ggccaagtct aaacgcactc tatagccctt taaactgtct tcctgtctcc 97860acctctcaag
tacagggatt atagggtata gcaccacacc caacccagta cttttattaa 97920tcacagtatg
taccacacac cccgaagaat gttggaatat agatgcaggc tgaaaagaac 97980accagccgat
tacctgccta agccctgccc cgaagcctac ccccacccca agttaaccac 98040caccccctct
atgttaagca ctgcctccct ctgtttcctg tgtgtatcat ttttctgagt 98100ctccctaaca
ttgtatttct tgtcctctgc ttgtttggct agctgtgtgt ttgctactct 98160gtttccagaa
ctgcacagaa tccaccatct cgcttaccct tcttgctcgc cttccctgtg 98220ctgtgaaccc
agagcagctg cttactagaa aagccaacca caaaagcagg tggagccctc 98280ccatcagaga
gcaccagccc tctcctgaaa gccactttat tttaggcacg gagttaatag 98340cgtacaaatg
acatccacag taatgtggaa ttagcatatg tctttttttt tttttccagg 98400aaagaatttt
gtatgtgttt gaaaagtcaa cttgttcagg cccttttctg acagggctgt 98460tttgattcca
gttgtctgac agcaggtgat ctgaccttgt gtttggaggc agaaaagagg 98520ccccaggaga
gttcaagaga aaacaggctc agaggactca caggcccctc cccctcttcc 98580ccccacccca
cccccctcct gccagccctt actgaggtgg ctttggccca tagctgccct 98640agcccaggga
cccagtggca gacagaagca gacctacttt ggtttccatg acaactgcag 98700gcatcaggag
gcggaccaag tgagccgcag ccaacaaggc agctggtttg aagggtgttg 98760atctctctgc
agaccagcaa ggcagaacct ctagggacca gcagcaacag aagccaaaaa 98820ggagcctcta
aatctggacc tgcaaaatcc ttagggacct gtctacacag ctcagccact 98880cacctgccac
catccttcac ctacccacct ggacaggcac accactgtgg atatatgctc 98940atacctaaag
catagcagac ttgtacccag acccacctcc acctacacaa atacagcctg 99000ctacatctat
tcacaccccg atgaaaagaa gcacagacca aaagatccag gcacacactc 99060aagatgcgca
cacccattta cacaggtgac acgcccagga agttcacctt atcacgagga 99120cactctcaga
tacatatacc cagattcaga acacaacctc taggtgccga cacacatgag 99180gcacatgaac
ccacgctttc tgaaccaact cagaaacagc attgctgttc ccgaggtgcc 99240tcagctgaat
gacagagtcc aacaaatgac atgcgggcac acataccctc cttctgcttc 99300aggagccaag
tcccccatgg agtccggccc ttaatcctct ttgtttatta gtgtttgtat 99360gcacgcttcc
tccagaaatg cttaaaggac aaaactctca gcatgctcct gttgttacaa 99420attaaaaata
aacagtgtac tgaagcaggg tatggtggca catgcctttg atcctggcac 99480tgagaaggca
ggggcaggtg gatcgtcagg agttcaaggc cagcctggtc tatctaaaaa 99540gaatactact
aataaactct tgctaactgt ctcacagagc cacatagctc tttaaagcac 99600ccagtgcacc
ccacactccc ataggcatgc tctacaatgc aaggtggggc ctgctgcttt 99660gcacacccaa
atggagggca atgcccagag catggagtag actcctaggc cacaggtcac 99720ctcctgagcc
agttataaca tctgacagac atagcctctg tccacagagg ccactgagag 99780cctagggtcc
cagaagcctc ctggaaggac attttgttcc tttgagttct ctgaaaatcc 99840aaagacggct
ggcaccatct cagtcttacc ccaactgtag cttgtgaatc aacatcaaaa 99900tgagaaagac
tgtcctacac ccatgtgcct gtctgtctgt ccttacagca ccgttggtta 99960cagtcataat
tgccaggcat gttggctgtg ttgtgtactc tcacactggt gatgaagata 100020atctagaact
tagaattctc aaggacatca cagaaaacca caaccaatca aaatgcagag 100080ttggggagcc
cattcaaaac agagacatct cgctgggcgt ggtggcacat gcctttaatc 100140ccagcactcg
ggaggcagag gcaggcggat ttctgagttc gaggccagcc tggtctacaa 100200agtgagctcc
aggacagcca gggctataca gagaaaccct gtctcggaaa aaaaaaaaaa 100260aaaaaaaaaa
aaaaaaacag agacatctct aagacaactc ctgcacctta ggctccggga 100320tcactgcagg
aaagggggcg ggaaaattgc taagagccag agcagcaggg ggtttgctgt 100380gagaccgggt
cacctagaaa cgtcagaagc tacacccata aagactctcc aacacgctgc 100440ctagacatgg
gttgaacaag gatgattgct accgcggagc gaggagaggc catgcagcct 100500caaccccatg
cagctaagac cggccgctaa ggaatgaatg ccaagaacag gagaaaggct 100560tcctggggga
gagcacactg gttatccagc accaaacggt cagccctata aacacccatc 100620cgagtatcat
tatacaggct ggatggattt cattcatgta ttttggaata cacacataca 100680gttacataac
aaagatgaaa aaagaggtca tgaatttgaa agagagcgag gagaggcata 100740tgggagtggg
gtggagagaa gaaagggaag agggaaataa tataatctca aaaaaagaat 100800gtgtgtgtgt
gtgtgtgtgt gtgtgtgctt tttattctca gagttgttga gatagacaat 100860cgattccaca
ggttataatc tgatagctac tttttggttt tctcagtaat agtgactgtg 100920gagtgcctga
cagcacagtt tcatgtacac ctcatttgtg tccctgagta ggatgcagaa 100980ggaggagaca
gcgcagagct tagcaagacc cgggcctgag ggtttggaaa gtagctttgg 101040aacttggaaa
gatgtcagcc caggaaaggg agagaggagg cttcagggag gaagccactg 101100atgacgtagg
cctgaaagca caagtcagca tagtcaaata cagagctgga aagggccctg 101160atgcccacgg
agccagagca gagggtgtgg gcctgtgtag ctaggctcct ggagagagcg 101220agcgggcagg
taagagcaac agtaaactga gatctcccag actcgggtct ccagcctcaa 101280gcaaaggatt
ttgtcgctag tgaatcacca gctgtgggaa tgggtgatag ctgtgccatt 101340gggctggtag
tatagctccg gaggaagagt gcttgactaa gccctggctt ccatccccag 101400tccctccaaa
atttgtcatg gaggagcagg gctataaccc tcagctatca gagaggtgga 101460ggcaggagga
tcagaagttc aaggtcttct ttagatacaa agtgagttta aagccagcct 101520gggctacatt
ataccctatc tcaaaaccaa acaaccaatt aaggagagaa aggacagaag 101580ataatgaaaa
tatctcaagt agccagacag tagacatcga agcggggcca cctagggact 101640tcatgtgtcc
acgggggcag tagattttgc ccagtcatga acagagccag agtaccggtg 101700acaccccaca
tctagctcag agcctgaccc accaaaggct ttacataaat gttttctgaa 101760ctgcgtggcg
ccacggggtc acgcgaggaa aatggaatta agagtcgagt gacccgcagg 101820gctagttcag
gcctggtatt gactggttcc tggacctcgg ccggagattt aacctctcct 101880gttctcgatt
tccacgctgg taaagcgaat ccgataatgc cctgacctac atggcttagc 101940tgctgcgggg
ctgcagcagg atgcgggact cggcctggct ggagccatgc tggccgatcc 102000ctccagcgct
tgggactcac ctcgctccgg gaccagatgc aaggagagct ggctcagccg 102060tcagcaatta
cctgcgcccc cacccaacac ctgcgctcca ctttggagag ggcagatggt 102120gcaactaact
tctcagtacc gccccactcc cggcgccagc ctagaccaaa cgcagagcca 102180gcgcgggcca
gcgtgtagcc agttcaggac tccagcacca gagccccttc cgctcagcct 102240cagcacagta
cctccagctt cagctcctca ccagccctct aaactgtgaa cagggaagag 102300agctgggccc
ctgcttttct tataaactga ggatccgaga aatgaggtgg tttgcagaag 102360gaggcaccag
acagaagccc aagtctctcc aagtccgctg ctacgttatc tggagctgca 102420ataattccaa
ggactactct ggcaaagggg cctaagtgtt ccttggggac aggggcatgt 102480ttgctatatc
tgtatatctg tgtacgcgcg catgtgctca catacacaca cacactcaac 102540ttgtgctcca
agtaattcaa ggttagtgga gatctaagtc aagcctaaac caggattcaa 102600tgattatatt
tttaaaaaca ttaaaagagg cctggcatga tggctcagtg ggtgcttcct 102660taaccagaag
atctgagttg gattccccag aactcacaca gtggaagaag agaaccaact 102720tttgcaaatt
gtcctctggc agacatggtc tataaccccc acactcagac tgagtcagga 102780ggattgctgt
gagttcaagg tcagcctagg gtacttattg aaactttgac aaaagagaga 102840gagagagaga
gagagagaga gaggaaggaa ggaaagaaag aaagaaagaa agaaagaaag 102900aaagaaagag
aagaaagaaa aggaaggaag gaaggaagga aggaaagaaa ggaaagaaag 102960aaagaaagaa
agaaagaaag aaagaaagaa agggagaaag aaagaagaaa gaaaaggaag 103020gaaggaagga
aggaaagaaa aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaag 103080aaaggaaagg
aagaaaagga agaaaaggaa gaaagaaaga aaggaagaaa gaaagaaaga 103140aagaaagaaa
gaaagaaaga aagaaagaaa gagaaaatga gtgaaataaa ccagggagct 103200gtcccaccat
ggtggtgcac ttagaaggca gaagcaggca gatcttatga gttccaggcc 103260agcttggtct
acataattag tccctggaca gccagggcta tgtacataga ccctgtctct 103320aaagaaacaa
agctagagag atacatagtc aacaaaagcc ctgcctcgtg agaaagagaa 103380cctgagtttg
actcccagaa gtcacacagg gcttggcact tttctaatgc cagcactcag 103440aaggacagat
taaggtggat ccctgaggtc cactcactag ccagccgcca tagcctaatt 103500ggtgaggtcc
aaaaagcaag gtagtgaggc tggagaggta gctaagagta cttacagctc 103560ttgtcgagac
tcagagttca gttcaagcac ccataccagg tggctaacca cacctgtaac 103620tccagttccc
agggaccctc cgccccttga gcacctacaa acatgcaggc acacacacat 103680acaaataaat
aataagcgaa tcagaacata cacaaaatga catccaatgc taatacctga 103740ctcctcttgt
acacacacac acacacacac acacacacac acacacacac acaccacaga 103800gagaatggtg
agccgactct actactcttg gaactgttgg ttctcctgct tagaagggat 103860catgaaacaa
ctctaaaccc gctccggtga gtttactgtg ccctctttgg ctctcattac 103920ctgagaccta
tctgcctcct taacgatcca gttgaagcta gagagggttc agtggctaaa 103980aggacttgtt
gcacaaacac gaggacctga gtttagatct catcacccac ccataacaag 104040ccaggcttgg
tctcctgcct gcatacctgt catcccaaac tgtgaaggtg gtaaggcgga 104100cacaggagaa
tccctgggca tgatgtcagc cagactgact gaaaactttg agctctgggt 104160ttgaggagaa
accctgcctc aaaggagcaa agcagagtgc tagaggacag ttggcaccca 104220cctttgacct
gtgtgtgtac ctgtgtatac gtgtgtgagt ataccacaaa cacaatacac 104280acactaataa
acatatctat atataaacaa gaaatgcaaa gatacagttg tctctattgg 104340aactacctag
agcaaatcaa atgtcatcag tttccaactg gatccttttc acctcacaga 104400accaactaca
agaccaagca tcgatagagg agctagagaa aatacccaag gagctaaagg 104460gaactgcaac
cctataggtg gaacaacaat atgaactaac cagtaccccg gagctcttgt 104520ctctagctgc
atatgtatca aaagatggcc tagtcggcca tcactggaaa aagaggccca 104580ttggtcatgc
aaactttata tgccccagta caggggaaca ccagggccaa aaagtgggag 104640tgggtgggta
ggggagtggg gggaggggta tgggggactt ttgggatagc attggaaatg 104700taaatgagga
aaatacctaa ttaaaaaaat tatcataaaa aaaaaagacc aagcatgaga 104760ccaaaggaga
ctaactcttg gtcaagagca ggagaagcag gcaatatgct ctaaaatcaa 104820ctgctctaga
tgctggggat ccagaagtta tagctccagg taagacaaaa tgagggtgag 104880caacaggctg
gtaatggagg gaattgtgtg tgtcttctgg gagtggatag agctttccca 104940ggaattctgg
ggccacctcc tttggctcct tggatggttc tttctagttg tcatcacagc 105000aattgtcaac
tgtcaagaca ctggagtatg tcgtttagtg tggggatgac attataatta 105060agttcacagt
tatctggcag ccatcttaga tggcataggg agagacactt ctgcatgcag 105120gcatcttgtc
ctcagagact gtggtggcta atcttgattg tctactcgat gggctttaga 105180atcaccatgg
aaacaaatct ctggtcacat cagtgaggga ttatctacat taggttaagg 105240gagttggaag
acccagccta agtgtgggca acaccattcc ttccatgggc tggggtcact 105300ccatggcctg
aggtccttcc atgggctggg gtcattccat gggctggggt cattccatgg 105360gctggggtcc
ttccattggc tggggtcctc ccatggctgg ggtcctccca tgggctggag 105420tcattccatg
ggctggggtc cttccatggg ctggggtcct tccatggctg gggtccttcc 105480atggctgggg
tccttccatg ggctggggtc cttccatggg ctggggtcct tccatggctg 105540gggtccttcc
atgggctgag gtcattccat gggctggggt cattccatgg gctggggtcc 105600ttccatgggc
tggggtcctc ccatgggctg gggtcctccc atggactgga gtcattccat 105660gggctggggt
ccttccatgg ctggggtcct tccatggctg gggtccttcc atggctgggg 105720tccttccatg
gctggggtcc ttccatgggc tggggtcctt ccatggctgg ggtccttcca 105780tgggctgggg
ccattctgtg atatgctttc tgggattgaa taaaaaggag aacatgagtg 105840agcacatgct
ttcatctctt tctacttctt aactagagac acagcgtgaa cgttggcttc 105900ttctgtccgt
gctggtgtga ctttcccact agggaaggac tgtctcccct agcaccctga 105960gctaaaacac
acccttcctt tcctaagttg cgtttgtgca gtatttttgt agccgtcaca 106020atcaactgat
cccatgaccg agcaaggaga aaagcagcta ggctgtgtag gtcaactctt 106080ctcacagccc
agtctgctga agagggtaac ttactctctg acggaatggt taagctcctc 106140ccccacccgc
cagaagtcct gctgtgagct cctctccctc caccttgagt ttcagagttc 106200agtgcaaatt
tgagttctta gtttgtgtca aggagtgtgc taagacgctc cctcgacatc 106260tcatcgctca
ccccaggagg tggctcctca gtacccccca tttgacagat gaagctgggg 106320agcaaaggac
ctgggacaaa gagacttagc tcctctctgc taccctgcct gggctctcga 106380ggagagagaa
ggattcgtgc gctctctccc agctgctcca gcagaagggc tggaactagt 106440gccgctgttc
ttagagtcca aaccgctggc tttgcaccca ctcccacatg ttacgtacga 106500tggcctgggc
aagccacctg tcttgtctcc tgaccgtaaa agagagggca acggtgtcgc 106560ccagcttctc
tgtcataacg ggggtgaact gagatgcact tgtctaagga cagaaagatt 106620gcttagtagt
tgagtggttg ctgctcttcc agaggacatg agttcaattc cctataacca 106680catgcccctc
ccccaccccc accctcacct ccacccccgc atgaaaatgc ctgtaactcc 106740cgcctcaaag
aatcggatgc cctcttctgg cctccgttag aaactgcatg catattgtga 106800acccacaccg
atacgcagta cacattaatt aaaagtaaat taagtctttt aaaaaggaga 106860gatttgtcag
ggtgaccctg agcccgatga cccccacgtt aatccactgc agccggagcc 106920caggaaagtc
gagcaaacga ggtgattcct gccacagctg ggagggggct gagtctctcc 106980agattcatga
gctaagttca agtcctcaga tctcccatca ggcctggagt cactctgtaa 107040aatgatttgt
gaagtgacaa gcaaaaatat attaccaatt taagagtgtg atttgcctgc 107100aactttttaa
tcctccggct gttgttgaat agattaaagt gtctgctttg atccatgcat 107160ttagatggag
acataaatat agccatcact tattttccca gccgcaggga tgggtgtcgt 107220gctgtgtctc
acaggcttcc gaccccgcca gggtacggca agagaatgac ctttttgcca 107280ttcaaatctc
tcttgcattt cagccctgac ttttcagctc ctgaccgggc ctatcagcag 107340cctcctaatt
cgatcactgc tcactccagg aaacagtcac caggaaggag gtccggcgca 107400ggcgggaagc
agcggccgcg cagtgccctg gtgctgtgaa cttcccctgg ctcgccagag 107460ccctgcaaaa
ataaatctcc ggagaaatag attttgaaga ggaattcggc acatagatct 107520tctgtcagcg
gagcagactc tgcctcagcc gtttttcagg ctcgctgagt atccagaaat 107580acatctattt
ttacatggct ctctagcgag agttcctctt gcctggaggg gtaagaggcc 107640gtggaaggag
tcagaggatg ggagaggaga ggggtgcggg cactgactgg agaaggacag 107700ggaggtgacc
gtgcagtgct ggtcttcccg gttttcctgc atcctgcagg accttgggtt 107760tgccaaccaa
gtttgggttt gcctcgtcgc tatgaaggct ctgtgtgtcc cttggcccac 107820cggacccatc
ttagtaacag gcctgatgtc cccggagaag acaatacact acggcagttt 107880ggcgcgcgcg
cgcacaaaga gctgcagcac cgcccggggc tcactgtttt gttctcggcc 107940tagctgtcgc
ggtgaacagc aggagccatg gaccagatgg ctggagggag gtgcgagcgg 108000atcgcactgg
caggcaatta ggcctcaaac aatggcccgt gaaatgtcag aagtggcaag 108060gaagggtcgt
ggtggaacag cgggatgaca acgtaaggat ggcgccagga accccggaga 108120cagttcctgc
ttgctcccac aggcccctct ggcagaggga acactcaatg acccttctcc 108180ccaatgccca
cgcagactcc tctgaagata aagaaaaggc tgaggggaag ctatagtgca 108240gatggtgagc
cccaggtgta gatcgggtca gtagatgctg gcaccaaata aaacctgtca 108300tgacgataca
cacatgcgat cccagcactt aaagaggcgg gaggaggatc aggagttcaa 108360gatcatccat
ggccacatgt atagtgagtt cgaaggcagc cttagatata ggtgacttca 108420aaagggggcg
tgggagagag cgaaagaacc gggggggggg gggattgaaa gagaaacagg 108480agaaggaaac
agtgctggag aaggagcaat gagagaagac agggaaggga ggtgaggaga 108540gagagtgtgg
agaggagagg agtaggaacc gcccctcccg gtggctgcca gcaaccacga 108600gaaccccaca
cccactagat gctggggtta aagtgaggct aagagatggc gacacccacc 108660cccttggcca
ccacaactaa gaattatgta gagtaattaa tcaagagcta atgagaaatg 108720tgttttctct
cgcagcctag ccccacatca tattcttatt agcggaggtt attacaatag 108780taatcagcgt
gctccaggcg caaattgggt tttttgctcc actgccacca atttagaaaa 108840ccattaatgg
caagataagg cccccgtggc tcacaccggg ccaagcctgg gaacctgcag 108900ccaactctct
gctcatgaac ctacacgccc atgctccagg gggcgctcga gcaagcatcc 108960tggctcttct
gggacgacag agaagaaaaa gccaaccgct ttctaggagg tgctgtacct 109020gcgggaccat
agaactttct caaatgtgaa tcctatacaa cagtcacttg gatgagacaa 109080cctcatggaa
caaaacatta aagccaagtt tgccactaga gccagagcgc catatactgt 109140gcccttgagt
cctgcttcaa gccagtctgc tagaaacgct taggtgaatc tatagctctt 109200aggcaggagg
ttgcgatcag acacaagccc tggaacaagt ttctatcagt gaaaagagtg 109260gagagttaag
agtttggggt ttttcttata ataataataa taataataat aataataata 109320atagccgggc
gtggtagtgc acacctttaa tcccagcact tgggaggcag aggcaggcga 109380atttctgagt
tcgaggccag cctggtctac agagtgagtt ccaggacagc caggactata 109440cagagaaacc
ctgtctcgaa aaaccaaaac caaaacaaat aataataata ataaaaaaac 109500ttgttattta
cttatttgtg tgtataccac agcactcgca tgaagatcag aggacttctc 109560tccttccacc
atgaggggcc aagagattga actcacgttg tcagggtttg gaggcaagaa 109620ccgtcatgtt
tggcagcaaa gacctctacc tactgagccg tcaccatagc cctgctgaga 109680tagtttcata
acgataaatg cactctactt tttgatgatg ttctcagttc caaaattgtc 109740tccctgtgtg
cgtgtgtgtg cgcatgtgtg tgcgcatgtg tgtgcgtatg tgtgtgtgtg 109800tgtgtgtatg
tgtacttact catatgtctt tttatgtaca aaagataggt tccttcatgt 109860atagttggag
aagggctggg tgatctgact gggaggaaaa gaaagaaaac caggagtcac 109920gtctcttctg
cccccttgtg ggatcctgga tcaaactcag gttgtcagga ctgcatggca 109980gggtctactt
gctgagctgc ctcaccagtc ccctttcctt tttcaacatg tagaggccaa 110040gtatgtccct
ggttctacac agcagacaaa gagttaagaa gcaacagcta tactgcagtt 110100aagtcctgcc
ttttgtttgt ttggttggtt ggtttggttt tggtttgaga cagcctttct 110160ctctgtagcc
ctggctatcc tgaaactcac tctgtagacc aggctggctt tgaactcaca 110220gagatccagc
tgccactgcc tcctgagtgc tgggattaaa gatgtgcacc atcatcaccc 110280agcttagtca
tttctaccgg tcactattat ttagttagtg ttacttagtt ccttgaatat 110340gttgtccaca
aaaattctct caaataatta actacttcat cctgtggaat aaaagatttg 110400agtgaggcag
acctaagttt gaagtctgtc tacttatcac tggcttttgg tttgggattt 110460tatttatata
cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgca 110520tatgtgtata
tgtgtatgca cacatgcatg caggtaccca ctggagccag aagagggtgt 110580cagggcccct
ggaattacaa gtagttgtga gccacacaat gtgggtgcta gatgtggctg 110640ctagacatgt
aagctagaca tgggatctag gaataaaatt cggaaataac aagcactcaa 110700ccactgagct
atccctccaa cctgtctgtc tagttttgag aaaagcatta gcctgctaaa 110760gcctccattt
cttcatctat agaatgggac tgtacctcca tgttctttga aagttccaaa 110820gacatatccc
tgtgtgcttt ggtaaataca gagcacctgg aagtctcagg cactatttga 110880gatgcaatat
atggagaaag gactcatctg gggatctccc taaggatgcc cgagagacca 110940gcaggtatga
tacaaaagag aattagccat ttgacataag agagacatga agatcataca 111000ggtgcatgcc
aggcaagagg gatcctgagc ctagaggttg cctgtcagtg ctatgagcat 111060ttaggaaggg
ggctacctcc agacaagctt gggccaactg gtggaggaga tggcccaagt 111120ctgagaagac
atatgggatg aaggcggggg ttggggtgag ggcgtctcct gcatggagtg 111180gtccaaacag
aatcctggag atgtgaacag tgaggctagt ggcctctctg gatctaagga 111240acacacagca
gccaggcctt cccatctgag ccatctgcct tttcctcctc cgccatagct 111300ccaccccctc
tgttctgata tcatccgggc acagccagag gatggcacag cagaggggac 111360accttgggcc
taagacgtcc ttagcaagag cacctacata cccacataat gccccctcct 111420ccatgcctcc
ttaacaggac taaggttcaa tgctgctaat taacaaacag caatcaactc 111480agctaccccc
ccccacccct tcaccagacc ccgacccccc cgcccccatg cttcctttcc 111540ctcctgtgga
gaaggcacag ctgagctgca ggcaggggca gagggtggga gcaggctgag 111600gtagacacta
gagatccggc agaggggtta cactcaatat tgagttgtaa attcaacaaa 111660ctggagatct
ctctaacgcc catctagatg agcatctggg ataacagaca tttctagcta 111720gacggagctt
ttgcctgtca catggagtgc cattagttta gtcctcagac agtccatcac 111780aaccctcatt
taacaatgat ttaacagtgt ccttggcccg ctctaacact aaggaaggca 111840ctgtcatgta
tgctcaggag gtcacacagg gcatagaggt gacattcaac caatagacag 111900ggtgggtgga
aatatagatg catataggtc aacaggcagg tgaagggaca aaggtggtgg 111960tgggttagcc
cattttacag aacaagaaac tgacataagc caggaatgat gactgacacc 112020tgtactcccc
acacttgggt ggctgaggcc agaggattaa tgtgggtttg aggtcaacct 112080aggctccaga
gagggtctca agtaaaaagt taaaatgtaa aggaaaaaag aaagggaagg 112140agggagggaa
gaagggagga aaagagagga aataaaaaga gaaaagaaag tcgggcagtg 112200gtgatgatac
acactttttt aatggtgcac ttgggaaaca gaggtgggtg ggtctctgag 112260ttcaaggtca
gcctggacta cagacagcta gggctacaca gagaaccctg gaaaggagaa 112320gagaggagag
gggaggggag gggagggaga aagagagaga gagagagaga gagagagaga 112380gagagagaga
gagagagaga gagagagaga gagaagaaac tgagacaaag agaaaacatg 112440acttactcta
aactagacat ctagaggcag gtcagaagca ggtctcacca tccacccttc 112500tgttctctgc
attcccagaa gccagccccc acctctccaa tctcaggctg gctgccatga 112560cacccgtctc
tctgaaggct gagatgatga ggggaacccc agactccctg tgttccccct 112620cctctggaac
ccaaggcctc acataggggg cacagtatga aggtccttga gtttacagat 112680ctccagagaa
gccaggagtg ttaatcacac aggactgtct ttccaattgg aaacctgttc 112740gttcttccat
ctccaaagct gagacctgga agtgatgaac agtctggtga tctgtgttgt 112800tatctgttgg
accaggccat accaagctcc tacaaccaaa gctaatctaa atgaccctca 112860tagccagagg
ctgccccaac caggaccaga ggtagctaat aatctaaatg acctctatgc 112920tatctgtgtg
accaaaacca gaccagaccc ttaggccctt aagctagcac tggtaactca 112980tgtgacatcc
ctgccttacc tctcacctgt cccacttcct aagggcccag catgcctccc 113040gcactcctgc
tcctgtccct gaaccatgac agcctcacac caagttgagg tccctttgct 113100ttcagtttgt
ggcatcacct cttctcgact aagatctcat gggtctgggc aagcattggc 113160tccccctctg
cccagaatcc tttctttccc tctggtcttt ctaaagcttc aggtttctcg 113220gctcagaatc
cttttatctc cagtctaaaa gtcctaagtg ggccttccac acagtttggg 113280ggtttcaggg
acttgtgtgc atttgataaa aaaaaaaata gcccatggct agaggtattc 113340ttgccccccc
ccataaagct tggagccccc ataccacttt ccacccagga tcatgtggcc 113400tttgccacag
aagtctcctc agcaccacag actttgagtt cccttcccct gggcttggca 113460tgataccaga
accagtcctc tttccagcct gtctcctctt aaacaaagtc agagcctgag 113520gccatcaagt
ctttgcaggt attcacaatg acctctggac actacacaca acagatgtta 113580tcaagctaag
gctttggatt cagctggcca gtcaacctaa cctcctttat accttctgtg 113640tacccaacat
gggagacaga aaggtagaca aggtagagtc ctctgaagta ctagggttct 113700tcccgttaca
taggagagac cactgaaatc tatggttaac tcctgtctgt aatttaacaa 113760ttaattggtc
agtcaaggaa aagacaaaga taaaactcaa gggccttagc ttcttgggtt 113820ggttcaaggg
tttgcaatgt gtgcttcacc ttgtgatgtc atcagctccc tttcagatca 113880gcctcttcct
gatggggcca aatggcagag agagagctgc caaccggcag gcacatacct 113940atggtaccaa
gtatctgctt ttctcaaggt gcaaacaggg ctcctggcag aagaaggggg 114000agggaagcca
ggaagctaca gcctgtgcat gcaaatgaga cagctgcata attaattaac 114060acccaacagt
ttcattagga gacagagctt tgcactgact gtcttggttc agagaatagg 114120atctagcact
gttcaaagcc aaagtccgaa gctagagatg ctgcccacca ccgatgctgg 114180ggacaatact
tgttgctagg agaggttgcc tggggcagct ttggtcctat cttagacttc 114240gtaccaggga
ggatgagcct atgattgtca cataagtccc ctctgctcag gcctcaccca 114300cacttaggtg
tgggaaggga ggtgggcacc tcagagagcg gaaggggatg cccctggagc 114360atctgtctga
gctgtggctt cccccgaggg tcagtctttt ctacagctct gagaacagca 114420gccttgtttc
cagaatggtc tctaagcgct gtaggatact gtacggaatc caaagccaaa 114480ccaggacagc
taaatctcca gctcccttgt ccctccctca acaactaatg tttctctata 114540aaactgaggg
aggaaggtag aggaataggc agctccttgc taaaccttct gggagcctct 114600gtccccagcc
ctaatcccat cctagcttgc atttctgttg ctgtgataaa cactgacaaa 114660aaacaatttg
ggggaaaggg gagtttgggc ttaaacttgt atttcacagt ctatcattca 114720agaacatgag
ggcatgagtt caaagcaggc acataaaggc aggagctgaa agagaggcca 114780tggaagaaca
ctctcaacag ctagctccca tgacctggtc tgtttgcttt cttgtacacc 114840ccaagaccac
ctgccaaggg gtggcactgc ccctgtgggc tggaccccct cccagcagtc 114900actaatcaag
aaaacatccc cctatccccc acagccttgc atacaggcat tctggtggag 114960gcattttctc
catcgaggtt ccctcttccc agatgaccct agcttgtgtc aagttgggaa 115020gaaacagaac
aaaaacttaa gcagctaagt ttcatggaca agaaacatca tctctcagaa 115080ggaatcctag
caaacctcat gacctgcctc cgctttcctt tctggaacca tctctgctcg 115140ccacatacac
cctgggttgt atccacatca gactacctcc attttccacc cccaccccca 115200tgagtggcct
ctcatgtctc tgctactcct tcagttatga aggccctctt gcccttctca 115260cctacctgca
gactcctctc ctcaggagag ccttccttga cgcacaccct ccctactcct 115320ccacccccta
caaagctagc tattttcttc cctcttttct gcataacata tgcaataatt 115380attaatttac
ttgattgact ctgaccataa gggagtcacc ccttgagggt agagactgta 115440tcttccctgt
ctctgcatca ttaagtcctg ggctacactt caaaagtttg ccagatgagt 115500aagtgaataa
atctgttaag ttgaaaacac ctgttataga tccttgactc tttatatttc 115560aaccattcag
aagtttattc cctcgctaaa cctatagccc tgcactggag aaagcgtagg 115620gatgggaaag
ggaccctcaa ggggactgag gtcatcagga agcaacaaca gtggctggtc 115680ccggcaggat
aagagcctag gttggatagc ataaagctct ccattgttcc ccatagctaa 115740agcagctaaa
agaaccccag gggccttcca acctctttgg ccatcagtct tccgcatgtc 115800ctcacatccc
aacttccagc aatttctccc tccagcccga tccaggcaca caacagacat 115860agctctgcca
gaatcacaga gccctcctcc aaagctcctg gcccttgttc tccagttttc 115920ctggggtggc
cagagaagac ccatcctcag tgccatggtt tgaatatgct tggcccagga 115980agtggcacta
tttggaggtg tggccttgtt ggaatagatg tatcactgtg ggcatgggct 116040ttaagacctt
catcctagct gcctggaagt cagtattctg tgggagctaa aaaagggggc 116100cctggggatg
aagagggggg agatagaccc atgccccacc agagttttac ctattctctg 116160gtttgtcagg
tgtgggaggg ctgctacctt tccactcatc cctggatggg catccaagcc 116220tctgaccctc
tcttcagggg acggccaggg gcagccctac ctggggaccc tggagctact 116280ttgctaaagc
caccagggtt ataggagaga gggatgaggg aagatgttcc caatacctac 116340gagagtgcat
gcagccttga tgagcagaga ctctctatgg tttaagagct ttattataga 116400aatgcaggga
gaaagagaga agagagagag agagactaga gagaaagaga gtaagaggga 116460gagaagagag
gagaggagaa gagaggagaa aacaaagaga gagaagagag gagagaagac 116520aaagagaggg
gagagaaggt gagagtgagg ggtaagaggg agacaagtaa gagagtaagc 116580agtaagagag
cgaggtgggg ctgatcagcc ctttttatgg tctttactgt tgctaggtaa 116640ctggggagga
gttcagcctg aaggtcagaa gcttggacca ttgcctacgt gactactgac 116700catgcttctc
ttatgggggc atgtgggggg cttacgcagg ggccagagtt ccaggagcat 116760aagggaatgc
ctaccgtgtc atgaaggtga attatgactt cggggttcag acctcagctc 116820gactggagac
aagcctgcaa ttccccacag tattctgcta gcagccttaa attgtagatg 116880ttgaactctc
agctcctcct gcaccatgcc tgcctggatg ctgtcatgtt ctcaccttga 116940tgataatgga
ctgaacctct gaacctgtaa gccagcccca cttaaatgtt gtccttataa 117000gagttgtctt
ggtcatggta tctgttcaca gcagtagaat cctaagacac tcagttaaca 117060aggatattcg
cagttgatta tctgaggttt ctctgtaatt ggaaaagaaa gagcaacagg 117120caaatgtcaa
ttttggcttc cctgcctccc atccctgagg gatggaggga acaagagtcc 117180tgtctactct
caaggccttg ctccaaccag gtcttcttgc tcagcttttc tccataggct 117240catactatac
acacacacac acccccctca agggtgatat ttgggactta gccagcccca 117300tggagcaagc
ggcccacaag tccacagaca ctacagagag gttcagggac agtgagagag 117360aaatgtattt
ggtgtttgaa tgtgtgcaaa gggagggaca gcacccagac cccacaccac 117420ctcgtctatg
gagtcttatc ttcactgtgg tgttattcca cagctaagca cagccaacat 117480gcatcagctt
gtgaatttct agtcccaagt tcactgcccc cagagagact ttgtgatcag 117540ggcctacaac
tcttcttccc ttcacttccc tgggcccctc cctgaggagt tgaagcagag 117600acagtgtgga
aagcaagacc ctacctttag ccgccattct aatccagtgt ctaccactcc 117660ttgggggaaa
gatagcaggt gtcacaaggt ggtcacctct cctttccacc agaatgccac 117720ctcctgggtg
gaagtccaat gttaccttcc accctcacat acacatcact gagatcctgc 117780cttctttcct
gccacctctc cttcggtggt cagagatcat gtctttcttg cagatggcta 117840tgacagcctc
cagataggaa ccagtgggga ccccaccccc aactttgtct tcacaatgag 117900gttgatgtga
gcttgggggg gggggttcga gacagggttt ctctgtgtag tcctggctgt 117960cctggaactc
actctgtaga ccaggctggc ctcaaactca gaaatctgct tgcctctgct 118020tcccaagtgc
tgggattaaa ggcatgcacc accacatctg gcttgatatg agctttctaa 118080gccaattcca
atcatgcctt cccccaacat taaatttttt tttctaccca ggtcctcaat 118140ataggactca
aatctcccag aacaaatcat caacccctcc actccccgat gtggccttcc 118200cccagtccct
tgaccatctc tgaacttctt ttattctctc accccagggc cttagctcat 118260gccattcctt
catctctttt cctgtgttct caaggtcctg gacaccatgt accaactgca 118320cctctagcac
tccatacaga gaaacgaggt ctcgcctagc aaattgatgg ctgaaaatga 118380ggcaaaggat
gggtgggaaa gtcccatgga attgtagacg cttccccatc ttattcattt 118440acctgtggca
cttccattca aacccttgct gtacacaggc tgggcaaacc actgggctat 118500ccccagccca
actcttgtaa aaccgaacag atccagagag gtgaggcaaa ctcagccaag 118560gccacacaaa
gacttgtacc acatcccatc acccttggtt gtctcagaag agcccagaaa 118620gaccctagcc
agaagccgag gttggactga gaccctcagg atgagttcag ccagcagggg 118680gcaggagtaa
gccatggcca gtactaggct ctcgagaagg aaaactctgg ctaggaggca 118740gaagcaggca
gatttctgag tttgaggcca gcttacacct cccactgctc caagtctaac 118800cttgggcttc
ataacttcct gtggcctctc tggacaccaa gagccatttc cctaaggccc 118860aggatttata
gaggacagca aagatagcca gccactcaac cagccccagc cccatctgcc 118920agagaccagg
catccagacc ctggtagggg gaagctgtgg ctggtaaata aaaaaattta 118980ttaagaatat
gttagctgag ccgggcagtg gtggtgcacg tctttaatcc cagtacttgg 119040gaggcagagg
caggcggatt tctgagttca aggccagcct ggtctacaga gtgagttcca 119100agtcagccag
ggctacacag agaaaccctg tctcgaaaaa agaaagaaag aaagaaagaa 119160agaaagaaag
aaagaaagaa agaaagaaag aaagaaagga aggaaggaag gaaggaagga 119220aggaaggaag
gaaggaagaa aggaaggaga gagagagaga gagagagaga gagagagaga 119280gagagagaaa
gaaagaaaga aagaaagaaa gaaagagaaa gaaagaaaaa gaaagaaaag 119340aaaagaaaag
aaagaaaaga gaatatgtca gctggagtga agcaatggct cggtctgtaa 119400agaatttgcc
ttataaacac aaggacctga gttcaattcc cagaatccag taaaaaacgc 119460cctgttccta
agccagtgta agaggcaaag aaaggagggc ccttgggcct ggctggccag 119520tctgtctagt
ttaattggtg ggttccaggc caatgagaga tgctgtctca aaggaggtgg 119580acaagttctc
tgaggtgaca ccaagactgt cctccagcct gacacacagg aaagcagcag 119640gcttgcttgc
acagcgcctg cctgcccttc atggtggcca gccttccttc ctcttcctgc 119700tcactctagt
gaagacccca gggtagtgag gagaagctgg agaggaaaca aggaaccagc 119760agacagctgg
gggtgctggc cacacactcc ccaaccctgg cagcacaagc cccatcattg 119820ggtgctaatt
aaatccccct aatgaggaaa acggatgcag gagctggctc ctccgtggcc 119880tccccggccc
accgcccttg cctctccatc ggacttatcg ctcgtcacag gatgtttaca 119940ataattttta
atttgtgcaa ttattaatca cttttctatc tccctcattt gcataataat 120000tagtcatctc
actgtttggc atgcctgtga atgacagtgt tttaaattga attaagattt 120060taatattcta
ttttcctgct ttcttcccct ccacacgcta atcaaagtca gatttggcag 120120ccagagggag
ggtacggagg aggttggcag gcactggact tggcccattc tgtgctcctg 120180agaaccaacc
gtgctgagaa cagggcctgt ggagaaggca acaagcaatc accctactcc 120240aaacggaggc
tgaaggggtt aacccagcca tagctaattg agcagaggta atgaggagtg 120300gggaggggca
gccagggagg aggggtgggg agggaggagg gtcacaggct cagcggcacc 120360agagagcaag
aaaagtgctt ttcatttatt ttcttttcca agtaggctgc ttttggtaag 120420ggaacactag
aggggacatg ataggccagc cattgatccc cagttagact aggttaactg 120480tgaaggctct
gagtcccgca agtggaggaa gcaggctgga gcagcctaaa atcccattca 120540ttgcgtctct
ctcaacgtgc aagacaattt tctggggttg actccctgtt cttctcccca 120600cttctccaca
caccaacagg tcctctgccc aagttgggtg cctcacgggt gaggaacaag 120660aagtaaggga
tttccaccga caagggacag cagacaggcc acgtgtcccc taagttagag 120720gcagctgtgg
ctctacagat cattttctaa ccctaaatcc ttcttctaat cacgccaggg 120780attcagcctc
agcctggagg agggcctgtt ctattgctgc ctccctttgg attgcctttc 120840gtgttgccat
ggtgatccct aggctaccca ggatacccat tgctgcccca gaattctctg 120900cttgagcaga
gcggctctcc cttcagcctg tttagaacac ctttcttttt actatgatat 120960gctcaagctc
tgcaaaaacc aacaccgctt tgtccataca ggtgagtcgg gatggacatt 121020ggctcccaga
gatgggctct gtgcaaacaa tatgaaggca ggtcagccat cacaggcaag 121080gggctggaaa
ccacactcca acacagccac caagctcttc ccccacacca cacaagggct 121140ttcaactctg
cacatgagga ccaaaatcag gaaagtcccc catgagggaa agaagaaaag 121200gggtcttgtc
aggaggagag ctaggctgga agggtttgaa cccctacctc cagtgggtcg 121260cctccttctc
tggatcccct ttggctcagg acatcccaga gcgtccttgc cctcctacta 121320attcctgctg
acacacatgg agaggctctg gcctcaaggc tggtccatct aggtgcccac 121380acaacctagt
gtctgcccaa aggaatagca acagcaataa gccatcagga tttaggaaag 121440gcacagccca
atctaggatg aacaggaaag caatgagaag ccaggccggg agctttgagc 121500tgtgtcccca
ggccaaacca gagaaagcac tcagtctctc agccccagac aggctaagag 121560aatccagagt
atcacctggg gacatcagca ctaaggaaaa cccagacttg tagataatca 121620actctaacca
gtacagcctt gtttctggat ccttatggcc ctggaatgag aagtggtaag 121680gcccatagct
agtgctatag cagcctctac tggccacctt tgccttctat gctgtgccag 121740gagccctgca
tcctagttgt ttgggatggt cctgtgaaca cctgttgtca ttaatgctga 121800ggactcactc
tcagaaatac cccagtacac acatgacttc agtagccttc agtcacagcc 121860gagttccatg
tcccagaatg ccttcaaggg catagagaaa taggtggtgc gttaagatct 121920ctgaccccgg
cagcaaagca tctttctcat cagaccacag gagtgaataa ttcagagtcc 121980tctgtcctgg
gccaggacta aggcttcttg acagcgccac cgtgaagaag atggaaagca 122040ggtgtgtggt
gagcaggagg gaggggcctt ggcctaaaga gggtagaagg gatgagatgg 122100aagtatccag
agggcaggaa gtgccaaggg tgtgacatgc tattgctgca tgtgtccagc 122160agatggcaac
atagagcagt ctgcatcagc tcttggaagg gacctgcctg agccaggact 122220ggcttctgat
gtcctgcagt gcagagcgcg ctctctctct ctctctctct ctctctcctg 122280ttcttggtcc
atttcccccc agatgagtcc ttaggtaggc taaactacaa aatcgctaaa 122340gaatacattt
cataagccct atgcctacct tcccaggaga ggaaaattgg aagagaagcc 122400aggcctatta
gctccatgga ttcctggagc cctctgtctt ttcccagtgc ctgcgtggtg 122460caaagctcca
agggaaccct ttttccctca cccactgggt cagggattct gagtccagag 122520atgaagagac
ctgtgtgagc tgagggaatg tctccacggt ctgtcattca gagatgttca 122580tgccgattag
cagcatggtg atgggcaatg tccacttacc atcaggatct gcagaatgtg 122640aggatctagg
aacggcagcc atagctgcta tctcatagag ctctatcagg cggagagaac 122700ctgagctgct
actgacagat ctccagcatc tcctccttct gagtcccctc caggtaaaac 122760agaggccaga
ctggaagtct cagaaggcac accctgccta cacaagcata ttactatcac 122820aagcttgggt
tgctgtccta gggccccagt cccagaccat taacttgctc tatggatcca 122880agactctcta
ggcatgtgga tagagacaat ttggagtctt aagttcccta ggcagaagga 122940gatttttcag
aaaaggaata atgaagatct tcaaatccag gaagatttga tgccttcaaa 123000ggtgttcagc
ccacacctac acatcattca cgaactagtc actgagtctt caagtccaca 123060cttggttagt
tggttcatct tgctttgtat tgaaggttgg cctcaagttc actatgttag 123120ccccagctgg
ccccaaactc ccaataatcc tcctgactca gcctcccaag ttgcagagat 123180tacaagcata
ggccaccaca cccaggtgca agctcactct tgcttgccca gttcttacct 123240acagagaaag
cttatgctgg cctccgggtg aattcaacaa atattaaatg tcttgtatgg 123300gcccgacttt
gggctggttg ctggagattg tggcctctat ctttaataaa ctctaagtcc 123360acaggcgaag
gaaaacatga agttcgctgt actacagaga cctctagtag agttgggaat 123420ataacgcatc
atggagtgag cccctgatgc cactgtgtca gcagcaaggg acagggagaa 123480tgtccaggaa
ggaaatgaca tttgagcagg gtgctgaagg ctaagagccg gaggattgga 123540agtaaagacc
atgctcactc agggtgtgtg tagtccaggg aggggcaggt aaagaagtcc 123600cacaggctgt
gaaggctctc aagcaaaggc tgaggatgct ggaccttaca taagggcttc 123660tcccagaatc
tgcttccagc aggtcattcc tgacctcggc cttctctctg gtgtctgcac 123720tcctgcctct
cccctccccg ttctcacaaa agccacagac tccctgcctc tgggcctggc 123780aaagctactc
cataaatatc tgattggaca gttccctgtg ctaatgtggc agttatgtga 123840cccagcacac
acaggaccat cagttagcct agctaatgag atctcttcta aggagctgga 123900gagcaaagat
ctgtatgcac cctggtcacc tcccacctgc agttcccacc cagctggtta 123960tgaacccaag
gaccccacaa tccccaaaca ggataaacgt cgtcttcgga gtcccgtgaa 124020gctcaggaaa
gactcaacca ggaagcagat tctgtgcagg gaacactgca aacgtctaaa 124080gtagaactgg
gtgacagggc cactctctag ctgtgacaag ctgggcattc acctagtaac 124140ccaggtggct
gcttgagtgg tgactttgcc acactttcac aaggaggctt taaactggga 124200ctcagaagct
aagttctggt taggcatggc ggctgctgcc tgtaatctta gcacactggt 124260ggtggaggcg
agagggtcag gggttcaaga ccgttcttgg ctacatagca agttcagagc 124320cacataaaga
aaggcacctg tggccaagct tgacaatccg agttccatgc ctgggaccca 124380cgtggcagaa
ggatagaggt gactcccaca agttgtcctc tgaccacaca cacacacaca 124440cacacacaca
cacacacaca ccataaaagt ttgttttaaa agcactgatt cacttagggg 124500cagcaattat
accccagcag ataaagcaca ttccttaaag ggctgactat cagagttcga 124560tccctggagt
ccacataatg gtagaaggag aaaaccaact caacagagct gtcccctggc 124620ctccacacat
aggctgtggc atgcacgttc cacatcatac acacatgcac aagaatggta 124680aaatttacat
tttaaaacta ctgactaacc tctgagcctg tgggaggtta cccagaccat 124740gctccgatgg
aggctccctg agcttgctga catccttcct ggctcacaaa agtgttagct 124800cagctggaaa
tttctacttg aaaacgagtt agtctgtttt tataagccct gggatgggta 124860attcaaacaa
atggtgaagc cacagggaga gacaattgaa aatggctagt gttgctccag 124920aatggaatat
acatttgtcc caagaggggt gacagagtgg ggagtgttca actgtggggg 124980agtagcattt
aacagataca gctctgggat cggtgcgggg actcatggct gcagtccctc 125040tcctactcca
tatctaggat tagtgaatca acactgtcat tccatgcacc agggtgggac 125100actttgatca
aataaagaac aacagactgg gaaggaaggc cgaatgaagt gcaacccagt 125160gagtcatttt
ccagactcaa ggccctattt tgtgattgca ggttctgaaa aggagtcagg 125220taccggcaaa
ccaacatcac tggcagaatg cagctcaacc ctctgtctca ggaaacttgg 125280tgggtgtgca
gggctgggcg gactggaagt aaggacagga aagacatatg aggggtcaga 125340gcttggatat
gctgtacacc ctcacagaca gacagacaga cagacagaca ggataaacag 125400acacatacac
acaggacagt cacacacaca cacacacaca cacacaccta tggttctgtg 125460cataaatgta
tagtgaacta tgactcactg tatagtcagt cacacgcgca caaagtggaa 125520actcacagtt
agacctgaga caagtaacag agataaggct cagcaatctc aaggcctgat 125580tatttccaca
gtcacccatt cccctagatg ctggtcataa caggctgttg ctggggacag 125640agctgcctcc
tgttcctctc ctgaagccag tataacatat agaaaagttc catggcagcc 125700taagacaata
acctcagagc taatttctgt atcactcagg agctggggaa cagaggacaa 125760agtgagcagg
cacagtgggt cacagccctc ccctcagcta tctctgtatg ctctgtgact 125820gtgggtggct
gtcctctggc catctcccaa cctgatatcc cacctcgtca aaccttcttt 125880aaccccaaaa
ttcctccctg cctctaatgc tggtagagga caccggcttt tgttctgtcc 125940ccacagacct
caacttacta ggtccctgct acagttgcag ttgcccacat actagcagct 126000aacagcctaa
gacatctgtt tctgtctgag gattcactca ctctcatcct gtctgcccac 126060tctacttgac
acataccaat caaaaatgcc cctttttggg ctggagagat ggttcagtgg 126120ttaagagcac
tgactgctct tccagagctc ctgagttcaa ttcccagcaa ccacatggta 126180gctcacaacc
atctgtaatg ggacctgatg ccctcttctg gtgtgtctct gaagatgcta 126240cagtgtattc
atataaataa aaataaatat ttttttaatg cccatttctt taacagctaa 126300aggctatctt
tcctttcttt actggtctct cttgagcctc aaacacctag ccttccactt 126360gggtctgata
tctgaccaca aaaaatcagc tcacagaccc atccttcctt cctgtcacta 126420tggaaccaga
gtggcctctt caaggttctg ggatgtatac ttgtaacttt gatgaaagca 126480aggaacaaaa
gccccaatgt tctcctttct ctccccctta ggagacatgg acaacaccgt 126540gcctactcca
atgtcactga aaggttgtct tgcttgactc tccaggagcc cagtgtcagc 126600catctctacc
gtaagctacc cattcgccac agccacaaca ttcaaggcca aaagaaagaa 126660ccaaaccaat
cctggaatgt ctaactgttt ttgcagcttg ggatgtagct cagtttttag 126720agcaagttcc
tagcatgcag gacgtgctgg gttacatttg ctgaagaaac caggcctgta 126780ctgtaatccc
atcacttggg aggtagaggc aggaggatca gaaactcaag gctgcctttg 126840gctatgtaca
gagttcttgg ctaaccttag ctacataata aggctctctc aaaagaaaag 126900gaaaaaaagg
agggagggag ggagggagga acggatgcaa cgaaggaagg aatgaacgaa 126960ctgtatgacc
gaatgagggg acaaaaagac gggcaaccat cagggaaaag ggagtcaggt 127020atgagccgct
ttatcgctac cgtagccact gaccaactac ggactggtaa gcggggcggg 127080ctaaccgtaa
aaccatacct taatgccgac ctataagctg cccccctaat ggagtggtca 127140ccgccacgaa
agatctaggg actggaagag gcttcagagg ggggagcccc gtaaaaaggc 127200cggggtgacc
gcggagttcc ataaggtccc ccccccctgg caaacttaag ataaatcgac 127260ccccctagtc
ctagggggcg gcaacccccc agggcttttc ctaatccccc cccgttcccg 127320ctgaaagaac
cttggctggc ccccgttccc ccctgagcgc taataggaag aaaggccgcc 127380tctaccctga
ggcacccagg gggctttttt aatgaacgta aaagctgagt tggcgcgtac 127440aaaggaatcc
ccaggcggga ccaggtgctc acaagcctgg atgcccccta aggcccggcc 127500taaggacccc
caagannnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 127560nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnatggc 127620cactgtgctc
taaagccgtg tcgactagac aggcctcaaa gtcacagaga tccacctgct 127680tctgccttgc
aagtactggg attaaaggtg tgcaccacta cacccaaaat tttgaagttt 127740atgcagccta
tggcactgct agcctcaatt gagaaaaggc atgccatact gccctctagt 127800gaccagccta
ggaaatgaca gccagctgca aacaaggcag acagtggtct ctggcattct 127860aaggcagaga
aacagtatac atcttaatca aggtcaacag gcacccagaa tagaatcttt 127920attctcttgc
tacacttcaa tctctgcttg aaaacatagc aatcccctta gaaattgtga 127980gaccttaaaa
ctgcagtgag gacgtaaacc tgcctgtgga gaagaccctg tacagaagag 128040ctatgacgac
aggctaggag tagaatgtgc tcacctctgc aggtatccaa ggggatggcc 128100tgacggcctg
aagattcctc ctggagtccc ttggaggtgt tttaacacct tttaaaacaa 128160tttttaaaat
tatacctcta tttccttgtt gtgtgtgggc aggtagggtg cacgccatgt 128220ggcctatatg
gaggtccgaa gacaacttgc aggagtcagc tccttccctc caccatgtgg 128280aactggggga
tcgaactctg gtcatttgac ttggcagcaa gcgccttttt cactgaacca 128340tcttcctggt
cttagaagtc ttgtcttttt taggggcaga gggtaattct acgcttaaag 128400atatttgtag
agtcagcaca atgtgttctt tcctctaagc ttaacatcct agtaacgaaa 128460ggacatcaga
aaatttagac agagcactgg gaatttgtat aaactaaaaa ctagatttac 128520cattaggttt
tccattaata atttgttttg gccgattttc gggttttttt tttttttaaa 128580gacagggttt
cgtgtagccc taggctgacc gccaagtcca agaaaacctt gaactcctga 128640acctcctgcc
tatacctccc aggtgatgag cgtatagcct catctggttt ctatggtgct 128700ggagattgaa
catagggtac tctagcaact gagctacatc cctagcccct tggcttctca 128760gaggacaaga
tgagcaagag tggtttagag aacaaaccag cagctctggc cccagttcac 128820aatctaactt
gtagaatttt ttcatttcat aaatactgat catatacata atcatgttct 128880ttctctctcc
tccccctcga ccctcctaaa taacacggta ccaggcttgc tggctgtggg 128940atttacaggt
ataatcttct tacagaagta acagaagccc aaggacaaca cagctgctgt 129000gagaagcctg
tgctaacttc ccatgggggc cagggtgggg aggggccctc atttattccc 129060taagggatag
agcactgact gacttggatt ttgagatggt agcctaaatg agccttggaa 129120cccccatctt
cctgcctgtc tcccaaattc tggaattaca aatatgtcac catggtctgg 129180cttctgtctt
cactgttctt ttttaaatta cctttaattt tgtgtttgtg agcatgtaca 129240cgtgtgagtg
tgtgaaggct ccttccacca tgtgaatccc aggaaacaaa ctcaggttgt 129300caggccattt
cactgcccct gacttaaaaa aaaaattcca ccctaggaat tcatatcttt 129360aacaacttcc
ttagcaataa atagtacctg cgggctggag agatggctca gcagctaaga 129420gcactgactg
ctcttccaga ggtgctgaac tcttcttgag ttcaaatccc agcaaccaca 129480cggtggctca
caaccatctg taatgggatc tgatgccctc ttctggtgtg tctgaaagat 129540gctatagtgt
actcatatgc ataaaataaa taggtaaatc cttaaaaaaa atagtacctg 129600tattactttc
ttgattcctg ctgtccaaac tacatagaga tattcatcat gtaactaatt 129660catacaggtt
cctctgaagg gcatagccag gaaactactc tttttgtttt tttttttggt 129720tttttttttt
ttttatttga gacaaggtct ctctcggtcc aggctggccc atgatcctgg 129780tctttctcca
tctacctcac aaatactagg attagagtca tggatctttg taacaagtta 129840atgcctcttc
catgaaaatt acctacctca gaggttgtta gcagctagta acaataactc 129900acaggaagat
atctgcaaat catgcaatct ggctaaggga ccagttacca aaatacaaaa 129960tctactttgt
ttctttagtt tggggtaatg aaactgagac ttgcacatgg cagaagccta 130020ggcaaacact
ctaccactga gccatactcc caaccattcc agaaacaatt ctttacatga 130080aagtgtgtac
aagccgagta tggtggcaca cacctttaat cccagcactc agtaggcaga 130140cacaggtgta
cttctgttag cttgaggcca gttttctaca tagtaagttt ctgaacaacc 130200agagctatac
agtgagaccc tatctacaaa aataagaaaa aaatgtgcat atacatatat 130260ttatacacat
atgatgtaca tgtgtgtata catatgctgg gtccttatag atacatgaaa 130320aatgggcgaa
gtcccttaat agacatgaag atctataaag atgctcaaca tcaccatcca 130380ttatggaaac
cagcattgca gacttaccac ctcctatcca ccaggatagc tgtagtaaga 130440acagaagtac
agacaagatt gcagggaagc caaaactctc ataaactctt gggaagagac 130500ctggcgctta
ctcaacaagt cagagcatag atttccatag gactcaatgg ccccactccc 130560gagtccgtgt
atggatacac actgatagct gcagagtaga aaatgtttct ctttgcattt 130620agctaaccgg
gagtgaggca atgggctcac tggctgtcta ggtttgattg tctccatttt 130680tctactttca
cacttgtctt ttccttcctg ctttgtagag ttctgtcagg tagtcaatcc 130740ttcgtgtctg
caatccctcg ctgttacaca ttgccggtgt cttctcgatg tctgtagtca 130800tccttaactc
cgacatgacc tgctctgctg cacagagcgc ctggcttatg cagcagcccg 130860agcaatgagg
gtgaggtttg ccgtgagctg tcctcacact gtacagccgt cattgctccc 130920accgggcttt
actacctgtt tgagctcaga agcccagagc ccatctgagc cacactctag 130980cttcgctgta
cagttcacct gggtccttaa ttgcttcagg actgctgatg tggtatgaga 131040caggggcctt
cttcattttt gtccatataa cctaattttc tgagcctcag cggccacctt 131100tcccactaac
atgtaacact accttatcac acatacagtc caatattcct gaacttggtt 131160taacaccaaa
ttctgatttt cacagaacac ttttacccac acaggtaaat taatgaaaac 131220tgcaatcact
caatactccc gagacaccca gaaatttcat acagctggaa ttcttcccaa 131280gcagaatacc
cagttaggaa atgattataa aaaaataaat atgtgtttat ttttaagaaa 131340aaggaaaaca
ctggccaaga acaaaccctg ggataaagaa gtcaccgtgt cctgcccaag 131400ccagccacag
acagtgaggg cacagccagg ttaggtgcct gtccaaaggt caggctgaca 131460gcaacttgct
ggtctgcgtc tcttagcagg actcctttag agctggatgt gagctggtgc 131520taacagcacc
acagcatcac atggcctcag gggtcacatg gcctgggggg ggggtggtgt 131580cacatatcct
ccacactcca cttgtaggca agctcctcca cagccttctt gctggcgagc 131640ctggcaaagc
gcttctgttc aaagccattg gatctgcaat caaaagagaa attctagtca 131700gccaaaactc
tcaacgttta ctttaaaagg aaggaagcca ggtggtggtg gcacatatct 131760ttgactccag
caatcaagag gcagaggcag gcagaggcca gtctggacta tagagagttc 131820cagaactgcc
agagctacac agagaaaccc tgtctcaaac aaacaaacaa aaaggaaagc 131880tatttatagg
aaaatattta aaccatatgc taaaaagtca aagcaacaaa acacacaaat 131940taaccctctt
ctcagtcccg gttcagactt acggacaact atcagacgct tagacaacta 132000tttcaaacct
ttattattct ctacaaagat tcaacacagc tcggcctggc ctgcatgggc 132060tgcggagtta
agttcatggt taagctggac aacttcacga agttttgcct caaaataagt 132120agtaaactga
agggacctaa ctcagtggca atggcagagc ccctaccagg ctatgagctc 132180aacacacggt
gcaaaaccaa agcacaactc acttgtggcc gatacccaca ggctcaattt 132240aaccgttggt
tacataagta ctgagttctc actggacatc cgggtgctac ggaagaatca 132300gggcaggaaa
atgaactgca caatacctgt gctgatgaac tcagacaagc gacacagaca 132360tttaactaaa
aagcaaaagc cagggctgaa aacgtggctc gggtgttaaa agcatttgtt 132420gctcttgcaa
acccaaaatg tgaacccctg gtaccattgg ataggctcac aatcaccttt 132480aactctagcg
ccaggggacc caagaccctc ttctggatta tagacactac tgacacacag 132540acacacaact
gcgactgaag agatggctca gcagttaaga acactggggt tcctctggaa 132600agcccgtatg
tcagctcact accatctgta actctagtcc cagggaatcc aaagctactg 132660ctgccctgag
ggtggtgcac agacacaaag ctaaaacacc cataaaaaca aacaaaatgg 132720aagagttaaa
ttaaaaaaaa aaaaaaaaaa accaaataaa aggaaaaact gttagaaaca 132780tgtgtgggat
atcaaagaaa cagaagtggg ggtggggaaa tatcagatga aggactaagc 132840aagctaaaac
acccataaag acaaacaaaa tggaagaatt aaattaaaaa aataaataaa 132900taaataaaag
gaaaaactgt tagaaacatg tgtgggatat caaagaaaca gaagtggggg 132960tggggaaata
tcagatgaag gactaagcaa gggcctttgt gggagtagcc ccaagctatg 133020cctgaaagca
gcagcaaacc cgcaggcaca gaaaaaagag ccctggtctt cgaaaggggt 133080gacgggtgtg
tgtgtggggt cggggggtca ctggcatggg cagagcctag agtgtgacaa 133140atggtgtagc
cacaagtcaa cactggaaag acaggtagag gccaaatccc tgtgagctta 133200gacaaactgt
aaaaacaaac aaatacaaat ttcatcccag aaagatggac ttaaaactgc 133260atttcagaca
tctctagaga tgtgcagtaa gaaagctagc acagcggcct gacaacagat 133320gaaggcagtg
atgccaggta gggatggcaa caggggccgt cgagaggaaa gagcagtagg 133380actgggtgac
tgactagtca cagcctgggt cagtaacctg agagagcaga tgagtgaaga 133440tgccacctgc
aggcgggtat gctttgcatg tgtgactgcg cctgaggcac ctcaagtgca 133500caagggcaga
ggatcggact atgacatatc tggacccaca cacagacagt ggctgaaggc 133560ctggctcaga
aaagaggcaa ccggaaggag caggagtgag agcagggagg ggttccagaa 133620ggagaactga
agaccactga aggttaacag agaaaggaca ctcacagggg ccaagacagg 133680accgagaaca
ggaacaggtc attatggaag ccaattctgg atgaggttca agtacatggt 133740gagtggacca
caaacttcaa attccttccc cttaccccaa cccttttctc tctccaaaaa 133800gccacccctt
ccttttttac tatttattat tttatattta ttttcctttg agacaaaaca 133860ctgcgcgcgc
gcgcgcatgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgc gcgtatttag 133920ggctccaaag
acagccaaag aaatgaagag cgcagcaggc acagtgcaac aggcacggtg 133980cagcaggcac
ggctatgaca agatccacct gcggctatgg agcaagtgcg agttcaggga 134040aattctcctg
ccaaagattc tgcagggtga ccagcaagca cagcagccag ccagcctgca 134100actgcagtcc
ctccttgacc tcaggaagaa ctagagtcag attccagaag cagcctgaag 134160gacagaagac
aacgccttag gctggcgcaa gtgcaaagtg gattctgaca ctcaaatagc 134220aattataaaa
cctgagcaaa ataagtagtg gtttaaggca tgtgtgagcg ctaaagcaga 134280aagaaacatc
ccaataggag ggggttagcc agagggtacg ttctcggtcc acacagctca 134340agtaggccac
aggcagaacc acaggctgac tggcttgagg tattagtggc agtgggaaga 134400gtggctacaa
aattaaggag aagtcctggg agagagacac tggttatgta cagcaaaggt 134460cacaccaagc
tttggtgact cactatgtat atgcagagga cctgtagcag ccctgtcaga 134520gtgcagcagc
cagaggcaag acctgagccg agatgttagc tgctgcccac tgcaagggag 134580acgggttcag
tgtagagtaa aactccagac aaaaatcagc agagaaacgc agcaggagcc 134640aaagctccac
tatgtattcc tcataaataa aagacctaac aaataagcca actggaaacg 134700gaaaataaca
tgtactcaaa aaaagttagc cagttacagt gtcagtcaca cataatctca 134760acagtcagga
agctatggta ggaaggtctg agtttgagat cagtttgggc tacatagcca 134820gctctaaatc
agactggcct acagagtgag accctgtccg tcccccaaag agaggggagg 134880caggggacag
gttattaaca aaaagcaagt ctgtggtgag cagaatgttg taatcagcag 134940acaaaacttc
aaaacaccat ttataaatat tttccaaaat gagaaaacag tctctaaatg 135000ggtgagcaga
tgggaaatct cagtgcagac atgcaagcca tcagatggga attctggacc 135060caacgcagct
gagacataac agcaactgag agaaaacaac taaggtatca ggacagttct 135120gtaaactctc
aagccacctt agcctaacag agttttataa agcaccatca tcccaagtaa 135180ttgctgaatg
tatattaagg gcatcagtca ctagggagaa tcaaaagaat gggaaaatat 135240tctacatgta
tttagagaac tttctcaatc taccactcaa gtaattttct gatggtgtat 135300aataaaaacg
tcagcatttg gaaggtgtgt aaaactcagc caacctgtaa gttacaaatg 135360accaacatat
gattcaagtg tgcactggta aaagatgtaa agaataataa agaccatgac 135420tggaaagatg
gctcaggagc tgctcttcca gaggacctgg gttcaattcc tagcacctat 135480ctgtaattcc
cgtcttgagg aatctgacaa ccccttctgg ctgccaagat tacttcctga 135540acagacttcc
atgtaggcaa aacacccaga cataaaaaat aaagaggaag aaaatgatca 135600tgaattgtgc
aggcatggcg gcacatgtct ttaatcccag aacttggtag gtagatctga 135660gtccaaggcc
agcctgtcta tatagggagt tccaggtgag ccaggactac tagagagacc 135720tgtctcaaag
gaaaaaaacc cacaaagatt ataaattgta atgcaaaagg atcaatagtt 135780ctctccatgg
ctacagacca cacaacagcc ttgaaggaga cagctcttct gtgtgccaca 135840ccttcctctt
ctgctggtga catggcaggc tgggttctcc tcctgcattt cagctcaaca 135900cttcacaata
gacaaattca gaacccagct gtctactatt agtctagtca ttaatgttat 135960ttgcaattaa
aattattttt gtttttttaa taattagttt tcgttaaaaa tagtggtaat 136020tatattagta
tataatggtt tattctatat agtgaataaa tgctctttta atttttaata 136080tagtaactat
aaatgtataa taaacataaa caaaagcttc ttggggtctc caaaagcttc 136140tttaaaaatt
ctatttgttt acagaggcac acacacacac gcacacgcac acgcacacgc 136200acacgcacgc
acgcacacac gcacgcacac acacgcacgc acacacacgc acacacacac 136260gcacgcacgc
acgcacgcac acacgcacac acacacacac acacgcacac acacgcacac 136320acacacacac
acacacacac acgcacgcac gcacacattc aaatgagtgt gtggaggtca 136380gagaacaatt
tgcaagaggc agttctctcc tgctatatgg gtatcaagac ttgaactcac 136440atcattagtc
ttagcagcaa gcgcctttgc ccacagagca atctcagtaa cacagagtat 136500caaggggtct
tgagattgaa aactcggaga accctcacac tacacgctca tgttccatgt 136560ggacaaaggg
agatgggatc tgcgacaact ggcagaagcc atcccatcag tcaggaagcc 136620cgagtacact
ctgagacgct ggccagtaac cagatgaggg ggcaagactg gaacattacc 136680cggggctccc
tcccagaatt acagagaatt aaatgttcaa acacaacatg ttaaagacat 136740aacacagaga
tggctcagca ggtaagagca ctgactgctc taccaaaagt cctgagttca 136800aatcccagaa
accacatggt ggctcacaac cacccttaat gagatctgat gccctcttct 136860ggcgcttact
tatttataat aataaataca tcttttttaa aaaaaaccac aaaatcgggg 136920cagttgtggc
gcatgccttt aatcccaagt actggcagag gcagaggcag gcagatttct 136980gagtttgagg
ccagcctggt ctacagaatg agttccagga cagccagggc tatacagaga 137040aaccctgtct
caaaaaaaca aacaaacaac ccccctcccc caaaacatac aaaaacacct 137100acaacacaga
aaaggctcaa gaccacagcc cttgtccacc ctctaaccct tagaatactg 137160agcatgagca
atgtggcaaa caaagtgggg cttgtccgtc actcatcctg agcttttcca 137220agtttatggg
aaggagttgg gagaaaccca agccttgaaa taccgagctc aggagctgaa 137280gcacgagttg
cttgctactc cctgtgactg cagagtgaga gcaagggtgg agggacctta 137340gactctggac
aaagcctact gtggccccca ggctctatcc ccatgaccta ggaggtagtg 137400cacgagttgg
agtcagccta gctaggaagt gagactctgt ctcaaaaagt aggaaaaaat 137460aaatataaaa
aagaaaaaga aaaaaaaaaa ggaaacgaaa accagaaagg gtcaaggtca 137520ggcagaagag
aaaacaaaaa tataggaaat agactcacct gtccactcca tcccagcgat 137580acccaggcca
aatgttgaat ctattgggag gaggagcagg accactgtag cggggcttca 137640ctaaagacag
gaatgagaaa aaagaaatta gctactgaca caatttaatt cagagctaga 137700tggctatggg
agaaaattct tcatggaagt tcctattatt ttgattcaaa cttccaaaca 137760caagggcatt
acagtagtgt ggggcagccc tctgacaact ctcagtcacc tccagctcca 137820gcaaccccaa
gtctcacctt tcttattctt gttctcctta gctttattct tcttaataaa 137880gttggccatc
gggtcccctt ctctttcttg ttctctcagc atccgatcca gatcttcatc 137940atctatgtag
cgggccagag gcttctgcat ctccttcatt gcatcttcta cattctgttg 138000ctgctgccgg
ctctgggcaa gcctgggcaa aaaagaagca tcctgcttga gaattctctc 138060ctatactgag
agcccacagc gctgccctgg aggactccct ctttgtagca gccccagaat 138120ccggacgggt
agcttgaacc aaccatctca ggagactgtg cacctgaggc tcgccccgta 138180tcagctccca
gaaatgcaag gcagaggctg gctcaggtct tgcagtctag ctttgtgctc 138240aggggcgccc
ttaccctttc ccccactggg catatagctc atctcgctct gagtctttct 138300ctgcttttct
cctctgttcc aagcgctcta gcttcaaatt cctcttccga ccagacttgt 138360ctcgaaatac
agtttcagtg aattcaaact gtgctatgaa ggaaaaaaca cattttaaag 138420atacacacca
ggcatcacag tcagaaatca cattctagca ctagaaacca actgcttggg 138480atcttttgct
gaaagaactc tgcagacaga ccatcctacc agcactcttt cacatactgg 138540gaaggaaagg
agtgcttgta ctactgaggt aaggtacata aaagcaagga agtttccgat 138600agcaaataca
agccacatta acaacagaaa agagagctat aggaccttca gtggcccctg 138660caagctcaca
attgtacctc cgaggtctgt ggtgtcctgg tcttgtttct tgagttcctg 138720gtgctcccgc
tgaacatcag tgaccaaccc agtttttgct ccggaataca tgtgtgcagt 138780ctgtgcaaga
gaaaaggaat acatgtgtac agcctatgca aggggaatac acgtgtgcag 138840tctgtgcaag
agaagaggca acagcaacac catttttcca ggaggcagat agctgctcca 138900gtgcctgact
gttagctata accaaaccaa aacctctagt tttatattct cagtattgac 138960cacaaacagg
gctcacaaca tagaatggga aatatctaat ctcatagaac actttatggt 139020atcaaatttt
aaagtaaaca gaaacacaaa catggggcac atagaaggga gtaagaattt 139080gcatgacttc
tctttttttt tttttttttt aaaaaaaaaa gatagagtcc cctacagcac 139140aggctggctt
tgaactcact tatgcacatt ttaaaaagca aaaagctgac atttagagga 139200atataatttc
tcgtccaatc ccacagatac taagtagcag aagtagaatt tacagctatt 139260attggtttca
cagggttctg cacttctaac tgcactttat aatctgtaag cctcaattta 139320ctgttaggaa
aacaggtggt gccagcctgt atatctatca acaggtggga agaggcagat 139380gggtcagaag
ttcaaggcca gccttggagt acactcaaaa caacaaagac aagacactga 139440gatgagactg
gtggcattac aaggctctga gaggcagctg ggcactcctg atccaaaacc 139500agaaatgcac
aatagtccaa aatctacaac attctgagca ccatttgggt gcagaagcac 139560agccttcaaa
ctccaacact ctggttccca agcttcactg aggcccagct aagacgagtt 139620ccacccatgt
caccgtcaga gaaagttcca gaaatgcttc taactccaac ttcctgtacc 139680actttctcat
tctctgctgg aggagtcacc ctgataaaga aagacacaac tcctggaaac 139740ctaccttctt
gccaggacgg ggactccttc gaggtggaga gaggtcagaa tcagaggatt 139800tggtcctctg
tcttctccgg ggtggagaga ggtcggagtc agagctctgc cgccttggtc 139860tgttccgtgg
tggtgacaga tctgaatcag aatcctggtg ccccgaattt ttttttttcc 139920gtggaggaga
aagatctgaa tcagaggctt tttggtagac acctaagtag aaaagaacaa 139980aagcgtctat
gaaatctcct gtgtctaaga gaatctaggg attaaagaat gaattaagga 140040tggggatggt
tcagcagtaa aatgcctgcc tagtacgtca gacctgggtt tggtcctcag 140100cacaggagag
aaggggagga ccattaatct ccttaggaga ttgcttaaaa gaacttacca 140160tgctgggcac
ggtgtctttt tagccatcct atgaaataac atgactaacc aaaacacagg 140220cacaagtgac
acagagaaga acaaaggcgg gggcttggtt tcctggctac cagtgtctgg 140280tgactttgaa
aagcgtatga gatctcagac acagtctctc actgccaccc tcttcagaac 140340tggcatcaga
aatgagttgg cccgtgcggt gtggcagagt caggaagacc tggactatat 140400gctgatctcc
ccagactcaa gaaaacaaag taatttcatt ttaagattaa aactatagct 140460aaaacaaatg
atgaagtaaa acaaaaccct ttctgcaggg gcctgttcta gatgacagtg 140520tcaccagtca
cctcctgaaa agccactata tagcaggtac taggtagtag caacagccac 140580acattctgac
ctagtaaata actccatagt tttctaggaa cctatcagtt aaatccccag 140640gagatctaag
ataagaaata atacaggggg ctggtgagat ggctcagtgg gtaagagcac 140700ccgactgctc
ttccgaaggt ccggagttca aatcccagca accacatggt ggctcacaac 140760catctgtaac
aagtgactcc ctcttctgga atgtctgaag acagctacag tgtacttaca 140820tataataaat
aaatctttta aaaaaaaaaa aaaagaaata atacagggct agagagacag 140880ctcagcagtt
aagagcactg actgctcttc cagagctcct gagttcaatt cccagcaacc 140940acatggtggc
tcacaatcat ctgtaatggg atctgatgcc ctcttctggt gtgtctgaag 141000agggcaatag
tgcactaata tatttaaata aataaataac tcttaaaaaa aaaagaaaaa 141060gaaaaaagca
gcaatcccag ttgtgctatc agtgtatgta catgatgatt gtcaaatatc 141120ctcagggcaa
actcagggaa gactggtaag tggagcgagc aggcaagaat ccacaggcaa 141180caagtatgct
ctgtacactc aggcccaact acgcccaaca tgcgtgccca aaccacctaa 141240ggacaccggc
tacaacacta gcaatgacgt tgtctaaatg atacaatttt gtgacactgc 141300tgtgtctata
cattcctgta cgtcagtgta tttattatta ctgtatgtgt gcatgtgtgt 141360acatgatcgc
agacatacac atgcggaggt cagaggacaa ctttcagggg tcggttttct 141420ccttttactg
cagtggtgaa gacaatgctt taccctctga gcctctgagc ccaccccatc 141480tttgcctttt
tatggggagg gtgagtgagc aaaaggacat gaaactttcc ccccaccctt 141540ttatttttca
actcccctaa gtctagtctc tcttttttca aaactttcca aaagaaactc 141600attcttacac
tccccaggag gaaggtcctc ttatgcatag ccttatgctc acctttagaa 141660tcaagctgtt
tcttagcttc aaaatgagcc tttgcttgcc gtttccgtgg aggagagagg 141720tcagagtcgt
gctcgtactt gctgttggtg gagagtgatg ggtgagaggg tcctagccca 141780ctctgggatg
cagccttgct aggggctctt tctgcagctt tactactttt ggctttgtgc 141840agttccaaat
caggggactc atgatgggcc cttctgagat gctgtgtacc tgaagagtca 141900agagtccttc
tatgctgggc tgcagtaggg gagtggttat gggtctgtct cggagaagag 141960gtacctaagg
aaccatgatg gcctctccta ggagatacgg ctgaagaatt acgatgagac 142020ttcctggggg
gagaagcatc taagtcatgg cggactctcc tgggaggaga tggatccggg 142080gtgtcatggc
ggactctcct gggaggagat agatccgggg tgtcatgacg aactctcctt 142140gggggagata
gatccggggt gtcatgacga actctcctgg gaggagatgg gtctggggtg 142200tcatgacggg
ccttcctggg aggagatggg tctggggtgt catgacgggc ctttctggga 142260ggagatgtgt
ctggggtgtc atgacgggcc ttcctgggag gagatgggtc tggggtgtca 142320tgacgggcct
ttctgggagg agatgtgtct ggggtgtcat gacggaccct cctaggagga 142380gatgaatctt
ggtcatcgtg atgaaaatgt ccatcttcac cgtggcctaa acacaagagc 142440aaacagtaag
agtcccacaa tgtgctctgg cctaatggca cagagggtaa caaaccccac 142500ttaggagaca
attcttttgt cacctatgta taagaaaaga gcaagcacca ggaatattct 142560atagttaaat
agatctcaag aagtaagatt gaatcacagt gacctagact atagactgag 142620accgtctcaa
aggtttaaaa aaaagaaagg aaggaaagga agacacaggg gatggaggag 142680aagatgggag
agccttgttt atggaaagtc aggagaacag agaaatagtc acaaagtgaa 142740agacaaaact
ctggctctga ccacaggagc tgtttcattc tagaaccgtg gaaaggctgg 142800tctccaggct
ctgacaagtc agcctctaat gttccatgcc cttcttctaa agtcctgaca 142860tctttgtccc
atcatgtttt tcatcatcac tgacataaaa caaaccaggc attcccctaa 142920ggcagggaag
cagaaggaac ccatcctgga aatgagatgt gcagttgtgt tgctgctgac 142980actcacctcc
cagaagcttc cacttggcac tggagcggaa ggcctccatc tgctttacct 143040cttctggacg
ctcatccaca aactcagcca cctgcaggag taggggcact acagtgagga 143100aacccacagg
acccagccaa ggatcacttg tctcaagaac ccagagccat agcttacagg 143160cagagaactg
cctgcttctc cttgtgatcg catgactgac ttctactgcc catcatgaga 143220ctatcatacc
aaacagtgct agccgaagat caaaaattca aaaccatttt ctgctgaaaa 143280tgtatcatgt
ccacaccact gcacagtcaa aacattaagt tggagcaggg tgtggtggcg 143340cacgccttta
atcccagcac ttgggaggca gaggcaggtg gatttctgaa ttcaaggcca 143400gcctggtcta
cagagtgagt ttcaggatag ccagggctac acagagaaac cctatctcga 143460aaaaccaaac
caaaccaaac caaaccaaaa aaaaaaaaaa aacattaagt tgggactgtc 143520tgtctgtata
agcaccatga aggaaacagt gccacacagc tctcttgagg gtcacctctc 143580cccttgctca
gtgtcaagtc tgagaagcct ggatcatttc aaagtcctga caaaagtctc 143640cacgagatac
ataccacagg caaatctcca tcctcttcct cctccttttc cggcttagca 143700gtagagatag
ccgcccagcc cacatcatca tcaacaatcc gcattctaga tgagaacaat 143760aaaaactcaa
aacggaagtc atgctgtaac acgggcctac ctacctgttg ttctttacag 143820atggttgtga
gccaccatgt agttgctggg gattgaactc aggacctctg gaagagtagt 143880ctatactctg
agccatctct ccagcccctt acctgttgtt ctttgacatt tagagtgtgt 143940gtgtgtgtgt
gtgacagtga tggtgtatat atgtgatatg gcatgcatat ggaggccaga 144000ggacaacctg
caggagtcag ttctctccct ccgctatgtg ggttcagggg atggaattca 144060ggttgtcagg
cttgtcaagt gcagagccat gtcactgccc cctactggct tttaaactta 144120aaggtatggc
tcaatgtttg tgtgctgtca attcactcca tcactgtcca cctttggtaa 144180tatcagtttt
tacaaaggca cccccttcct tctgccagac ctactcttct cactgttaat 144240cacgaatctt
attttctttg ggccctgtgt attagtcagg gttctctaga gtcacagaac 144300ttatggatag
tctctagata gtaaaggaat ttattgatga tttacagtcg gcagcccaat 144360tcccaacaat
ggttcagtcg cagctatgaa tggaagtcca aggatctagc agctactcag 144420tctcacgcag
caagcaggcg aaggagcaag agctagagct agactccctt cttccaatgt 144480ccttatattg
tctccagcag aaggtgtagc ccagattaaa ggtgtgttcc accacacctt 144540taatcccaga
tgaaaggtgt agcccagatt aaaggtgttt tccttaaact gggagattca 144600atcttctgga
atccatagcc actatggctc aagatctcca aaccaagatc cagataagga 144660tctccaagcc
tcaagataag ggtcactggt gagccttcca attccggatt gtagttcatt 144720ccaaatattg
tcaagttgac aaccaggaat agccactaca ccctggtttt taataacttc 144780cttggaccta
tctttcttgc tcactgtctc ctactcccag agtagaaata cctctacaca 144840ctcttagaat
gctttcattt gtatttatca gcccatattc tcattaaatt ctaagttcca 144900acagccaagg
gctaaggcat tctcttattt attcccttct tcttgttgtt gttccctata 144960gctagcttcc
agctctctat cctccagccc agcctcccct gtgctgggat tatagacttt 145020taccaccata
tcctgctgac taatacattt tttgttcatc aaggcttctt caacacaact 145080gtcacaggag
gtattcagcc ctccacaccc atggacttca caactgcaaa ctcaaccagg 145140ggaaaaggaa
tggccaatgt attaaacaga tagactttct ttagttacaa tggcctatat 145200aacgtaacta
ctggcatact acctaagctg tagtgggctt ttaagtaatt aatctaagga 145260tgatttaaag
aggatgtgaa tagttgacat gaaaatagtg tatcattttg agcttcagga 145320accagtgccc
caattactgt aaggtggtgg caagccaata aataaatgtg tgccacacag 145380atgaactgtg
ctgcaaggag gaggttattt gaaatgccag gaacacatga cacagcttta 145440atcacaacaa
ccatttcaga caagtagtaa ggggctggga cttcaggctc agagagatga 145500acatctctct
cttttttttt tttttttttt tggttttttg agacagggtt tctctgtgta 145560gccctggctg
tcctggaact cactttgtag accaggctgg cctcaaactc agaaatccgc 145620ctgcctctgc
ctcccgagtg ctgggattaa aggcgtgtgc caccacgccc ggctgagatg 145680aacatctctt
gccctggacc actcaggcta taagtagcac agctaggatt ctaattctaa 145740tcagtattgc
tccaaagctt aaactttccc cctgcatgcc attgcccctt cttccaggga 145800catcagccac
actgaattca acaccacctt aactgaatat aggctcatct taactggtaa 145860caccacaaag
attccatcta taaatgaggt catgctcaag ctctaatgaa gagaagtgtg 145920gaaatgaggg
actaattcga cccagttcaa tggaccatac ggtaataata ctgttagacc 145980atgatactgc
cccacagaga gggtgagcca cactttgtat cctatctagt actctcttta 146040agctgataag
catttagtag acctgggggt ggagtgtgag aatggaatta gcccccagag 146100tttcaacttt
ctatccaaaa tagcaccttc agtaagctgc taaacttagg gctgctgctc 146160taaagcctac
aaatacagac atttcctttt gttctgtagg ttgatgttgg atatcctaac 146220ccaacctttc
cagattccag tggccaagtt actaatggac atttcatctg aactctgtct 146280cagcacatct
ctttgcaatc tggaagtata gtgtttaata taaatgtctg ctccattaca 146340atgttctgaa
agctatatgg tcaactattt tagaaagagg ccaggcacag gatgtgaact 146400gttcccattt
tagttgttac tgttagtagt agatgtgagt aataggatat gggtctttga 146460ttccagatca
gttcctggca ctttggaacc ctcagaaaga gatttttgga tctagaaaga 146520aagaaagaaa
gaaagaaaga aagaaagaag agggaagaga aaaagaagaa ggaaagaaag 146580agaagggaag
ggagaaagag agaaataaag tgagaaagaa aaaggtttga atcagctttg 146640ctattcttgg
acacgacttt caatctgtac atggaacgac gtaagctaca aacgcgggga 146700gaaagtgagt
taagttctag ctgcctttaa cacaaggaag gcgctgctca gaggatgagg 146760tctgagctgc
cagtggcagc tacaatcccg ccccggggca gtggagcggg gcctgagctc 146820gggccggggt
cggcagcacc gcgcgggcca ggacgaggaa gagctgcggc cgagggcgcc 146880accgggcagc
gcgacacctc accagtccac tcaccccttg ccgccagcgc ctccaggctt 146940cggccgtttt
ttgcgccgct tgcgaccggc ctcgggacct ccttccaagc cagcatctgt 147000cccagacaag
taacgcttca gatactcagc tttggtgagt ggcggagctg ccgccatggc 147060agcggcgagg
gcggggcaac agctcggcgt gggggacaaa attcttcaac gcgaaacggt 147120aggggtggag
ccagaagcgg aagctttagg acggggactt tttgaactgc tggacttaaa 147180gacttgagcc
ttaagaggct ccaggggaga gtgcgtgcat ctcgggctgg ctgtgctttt 147240cctgagacga
cgaatcggtg caacagcctg cagcccacgc tgtctcagct gagaagccac 147300aggccgatgt
aacatgatcc taccctggca gcatcagcgc cagagtaagg aagaacacct 147360gtatgaatgg
tgggacttac catagctgta ccactagggg cacattcttg agcagcgttt 147420taataatgga
cgctgtacca aacgtttcaa tttcaatcac ttttattgct ataaatacct 147480tttggtggga
agtctgctgg aagaggcttc cgggtaccat ttaggggaag tcaaacttgt 147540gactataaaa
gtttgatagg tttttatcaa acctgtactg accttctcac ctttgatatg 147600tctttctaaa
aaatgatata aactcttccc agtgaaatgg attcgtggtc agtgtggcaa 147660agaaaccagg
aagattctgg agtttcttct ataaagggtt aagtgtttta tgacttctca 147720cttaaccctc
acaatttttt tttctttcat ccagcaccga ggattaaacc caaggccttt 147780tgcacatggt
atgcaggagt tctatagaac tacatcccca ctcttttgaa tgttgaagat 147840ctaaattgcc
taagctgccc ctgaatttgt tagccttcct cctcagcctc tcaagtggct 147900ggacaccatg
acctaccctt cagttttatt agcctccttt atagataata agaactttcg 147960ggtaagtaca
ggaacccaca catcttcata ctgcctggct ctaatttttg ctagcagagg 148020ccaaacaagg
atggtgctgg ttatccagtt tgaattcgtt ttgtcttgaa tcagggtttt 148080tctgtgtagc
ccaggctgtc ctggaacttc ctctgtagac caaatcggct tcaaactcat 148140agaaccacct
gcctctgctg ggattaaagg tgtgtgccac cctgcttttc cagactgctt 148200taagctgcat
gagaacagct agactccaca caggtgtacc tggctcagag cagacaggat 148260ggcctattgg
agtgaatcaa atgctgcctc tacagcagcc acctcaagaa agatttgctt 148320aggaaactaa
actggttttt ccttcctcat ttcttttcat gaagacggac tctcactgca 148380tggcccaagc
tgtcctcagt ctcctcggag ctgagtgtga ctcagtgtga cccagcttag 148440tctagcacat
ggtaatcagt aaggacatga acgcagaggc gggtgtcgtt taaaggccat 148500cactttaatg
tggcgtcttc acctgtgcct gctcggcccc tccgacatcc ttccctgctg 148560agtcagtact
tcacatgccc agagccagca gaaacttgta tttcacttcc ccagacttca 148620aaggtccagc
actggaggtc agagagctga caggcaaacg gtgatggcag accgcctggt 148680gtttctggga
ttcttctcac gccgacttta aaacctccaa aagaaggtca aggagcacag 148740tagggctgca
gctgcctcgt ccgtcagctg ctaatcttgg gtgcttacat ttctaactca 148800agtggtaacc
tcttcaccat ggacgagggc ttgagcactc ctcgtcagtt ccccacagta 148860acagataacc
ctgcagtgtg agtggcactg tagctggcca gtgagctggc cactgctacc 148920gctgtggggc
caggcccgcc tcatagccct ctgtcttcat gtcattgagc ccgagctcct 148980cattttggtc
aaaggtgcgt ttgtaccgct cgaccttcat ctctggatcg tcttcaggtg 149040catacacatt
ctgcagggcc aagagcagac agacgacggt cagcgcctgt gcagcccgcc 149100atcccctccc
acggctgact ctcaacctcc gaagaaatgc acaggatttg cagggtctct 149160agagcccacg
gctacattct gcaaaagtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtat 149220gctagtatca
aacccaagcc cctgtacatg catacaagtg tttaaccccc agttctaagt 149280acttttatat
atgggccttc ctataaaaaa tgtagccaaa gttggtgatt gcttataatc 149340tcagcactct
ggagactgag gcagaaagat tacaaattta aagccagcca ggctacataa 149400caaagacttg
tctcaaaaaa aaaaaaaaag gttttgaggg agggggacca caatgatctt 149460aattatgtga
aaaactaggc cagttttgcc aggcccatca gtgctcatta atactaaagt 149520aaggaggagg
ccccaggttc aacacaattt tgctgcagtt tgatatggat caattgccag 149580atgtttgctt
gcccgttcag ccaacacctc tcggctttcc tgtcctgacc tctggccagg 149640ttcctattgc
tccttacttc acagtcagat gcagaatgga agctccaatg ctgagggtga 149700gaataagaac
aagacaagca gacccaggaa gaggaggtcc tactttctta tatattcact 149760ctgtacctag
ggccctgagc acgctagcca ggtaaacagt tactcttggc tttttcttca 149820cattattgta
tcttaagaca gtcttgaaaa tcgcacaggc tggtcttaaa ctttccattt 149880tcatggcctt
ctgaggacct aagattgcag ccctgcacta ggtctttgtt acacacactt 149940gggagtccca
ctatcaccac cttccccttt cttccttacc ttccaagtcc tgcccaaggc 150000cccaattgaa
gacttaacaa ggctttcctt gttaagggct atcatgcaaa ttctataaag 150060ttccgaaaat
atgtctccat agaaccacca ggaaggccta acttacctgc agataactgt 150120ttcctgctgg
atcattcatg ataaagtggg ccttcatctt gccctcgatg atctacagga 150180gagaggagga
cttagcaggt aactcttaca aagatcctgg aaggaagagg ctatggctgc 150240gagacaagag
ccaatccagt ttacaaagtg cagttcccaa aagtttaaag aaagggaaat 150300taggattgca
gaaatggcct gggtcctctt acctggccca acttctggct aaactcctgc 150360agtttctctg
actggtcagg attagagctg tcgcccagtg tgaatgggtt cttggttacc 150420tgtagcacaa
cagctggatt actacaacac agactgtatg ggtcattacg ctgaaccaca 150480aaccaggggt
ggggagcagt ggactcccag tgggagaagc ctgctctcca tatcccacaa 150540cgccttgctc
acttagggga ggggaggaag gtggcccgag aacaggacag gagaagatgt 150600ctatgagact
gctttgccaa gaaggaaact ggcagtaggg actggaatcc agtagcgttc 150660ttacagtatc
taatcccaat atggaaaaga aatgcaatgt acaattcaca aagaaaagcc 150720aggcagttac
ttggcctgca gtgccagcac atggaaggct gaggccgaga ggtggcaggt 150780gtgtgtgtgt
gtgtgtgtgt gtgtgtgtgt gtggagtgac ctcaaggcta gcctcaatta 150840tatcgcaaag
ccatctctca aataaataaa ataaacacat ttataagatc taatataatt 150900ttgcactact
gtttaggaaa taccgacaag aaaagtctcc acatattcac tacagatgtc 150960aaaaagaccc
ccttctattt tgtaatgagg taaatgactt aagatcacaa aataactaca 151020ctggcccact
gctagccttg agaatttcca ttaaaaattc ctataactgc tggacagtgg 151080tggcgcacac
ctttaatctc agcacttggg aggcagaggc aggtggattt ctgagttcaa 151140ggccagcttg
gtctacagag tgagttccag gacagtcagg gctacacaga gaaaccctgt 151200ctcgaaaaac
caaaccaaac caaacaaaca aacaaaatcc tataactaat ttctcttcct 151260tctcttcata
attaatactc aaatctcttg aatgagcttt tttttttttt tttttttttg 151320tttttcaaga
cagggtttct ctgtgtagcc ctggctgtcc tggaacttac tttgtagacc 151380aggctggcct
tgaactcaga aatccacctg cctctgcctc cctagtgctg ggattatact 151440cgtgcgccac
cacgcccggc ttaaaccagc tttaaggcaa agaaatcccc agttataagt 151500gacaaaacag
aatttggttt tggtaggagg catttgggat agggtctcag gctgtcctca 151560aatcctgtct
tcttgcccca gcttctcaag tgccatcata cccggacaaa caatgttacc 151620ccttcccact
gccaaactgc taacagaagc gatgcagcac actctgcact caccagttct 151680cggatgtctt
tcagcagtcc ttctagagtg gtgaacttgc ccccaagtac agccattccc 151740agttcaaact
caagctctgg gatttccaca ctacaggtct cagactataa gacaacaggt 151800caaatttaca
attaaatcac aggatggcag catagcttca tccaagagcc cttgtctagt 151860attaacagag
gtcccaggtt caatccatag cactagacag atggacagac atacagagag 151920acaaactgat
ttaaaactag gaacaaagaa agccaaccaa attaataaac cagtgacagt 151980ttgaagacaa
agttagaatg ttagtttact cttaatacct ggctaaaagc cagggcctca 152040ctcccccatc
tgaaccaaca cgaagttaac ataacaacct gaaactgagt cacacctaca 152100agctattgta
ccttgtcatt agggtcagag aagagcccat atagccaata gaaactaaaa 152160agcagccacg
tcattgctca ggaagactgg ggccaccttc tgagtctgta gtcccagtca 152220tggaaaaagc
ttcctcaggg tcactcaagc ccaggggagt tacagggttc cttgtgttct 152280taagcactaa
gatgatcact tcctctagac tgaagcggct atacgacaac agctattttc 152340caagtaggct
accttgagga ggtctctggt catgtctgag ggatctgtga tgtggagggt 152400gatcctggta
cccaaaggtt ctacagctcc tccggacttc acctgtggaa acaacggtca 152460ggagcaggtc
cagagaagag cccaggcctc acctgctgcc acaaagactt gggctttatg 152520taggctccca
tcaccagctt cccatgacgg aagctcctaa tccagcaagg gcatcagtga 152580cagaaataga
aaccatcaag agtccacaga acactgctcc gccctggtgg catgccaact 152640ttaggcaact
gccaagaaac cctgaatata ccttaaaaag aaaaaaagaa aagaaaagaa 152700aaaaccctga
gactgtcaga ggatgaaaga ggcttgtaag catttcagtc catccctgca 152760tttgctgtca
taatctagga atttagtcag ggctgggaca tggctcacta acagcgctct 152820tgccttgtct
gcatgaggcc ccaggtttgc tgttcactgt gtccccataa cttaagttta 152880atcagcttat
gctcgataca cttaggaatg aaggcttaca acctccacag cagccaccaa 152940atccattccc
gacagctccc ctgagttctt cactgagtca cactctgtcc aacctccagc 153000cttctgagaa
ccacaacccc ttccacaagg tcagttttcc gtccatcttg caatcttgta 153060tttccaactt
ctctctaggc taattctcag ctccttcagt ggctcctccc cagcactaag 153120cccccaaaag
acccaaatac agctgatgcc catcctcaag tagattcagg aagctggcag 153180actgctacaa
aggcgttgcc cctacgccaa tcttctccca cccacctcat tagtccgatg 153240cccacaattc
tcacagttgg tggccatgat gataacctct ttaaagtggg ggatttctgg 153300aagatggagt
taaagaagtc tatctgcttc aaggaaaaca cccccacccc cacccccaag 153360gaaaagcaaa
gccaagtccc acacaaacag atgcaggacc caagagtaca ataaacgggc 153420ctgtgctcac
aaacacggag acctggccac actcagaagc caggtatgca gtatgtagct 153480tcattaaagg
ttcatcctca ccactgagga taaagcactg gctttccctg aagggaaggc 153540tcccgtctgt
aatataacgt tcatgcccga gtcagctgaa gagcaaccca attgcctgct 153600gaaagatacg
gacaagcttc atgttggtct gagccggagc gttgcactct gggcagttag 153660tgttgaactg
gagcacctag gacataatat aggggcacag actgagcatc cccacccctt 153720cgagctgaag
acatcccgca ggtggtcacc catgtgagct gtgatggtga cacactggac 153780attcgtcagt
ctctacccac aactccacta tggtcttcaa agggagccag caccactcac 153840ttcgtttcta
aggtcttcct cttccgcctt ctcctctggt gcttctgcct gaaagaacag 153900aggcccaaac
cacaagttgg cagatagacc tcagcctaca gtagagccct gccctactta 153960aagagggaga
gaatgccttt gttccctgta aggtaccaaa ggacacctca aaggacagat 154020ggatagagaa
gccaaagcaa atccccagac aagagaaaga cggggctcaa ggctgggttc 154080ctgtgactga
cacctgcttt gtgagcgtga taaaaggccg agacaggatg cattggatga 154140tggtggcagc
aatagcaaag tgacttcagt gacttcagga cccagaacac agggcagccc 154200cagagcatcc
ctctgactta atcagtccac ttacttggag ccccagcatc tcagcttgct 154260gtggggttcg
gtcatagtat gtgatcacca aggcattatc tttctgggga gcatgtgggt 154320tttctacaaa
gctgtttccc gagggatcat caatgacctg acaaataaga gaggagagag 154380taagataaac
catatataac ttccatccag cgccagaaca cactagaaaa atcctgctcc 154440acttttttat
ctttaggttg ggcttcagca tagcctagcc tggcctatac cgtgctatga 154500agtcaaggat
gagtccaaac tcttgatctt cttacctctt ccacttgcca agctccatgg 154560ttaccagcat
cagtcagtgc caagggatgc tcgcctcctc cttacactga aagtggctgc 154620agtagcccag
tacttaccag tgtgaaaggg gaagccattt gctttaggtc cttcagtttg 154680ccaatgaact
catcaattct ctctgcgatg gcaccttcca ctgcctgtca ggaacaggat 154740gaaaactgca
gacttggcag tacaccccac accccaaccc tccaacagcc atatccctcc 154800agtcagatcc
ttaacatcca cttagactgg gagcacaggg acctgaattt tatagtgaga 154860cacaagaagc
tcatctgaag tttataaacg atgctggggg ttaggaggcg ggcttatttt 154920cttatttatt
attccactgc actgtaactt cgtctcagtg gggaactgtt gtaacagtgg 154980ggaactgttg
cttctggctc acaaaggtat ctgccatcac atttacatct tacatcacac 155040gggcacataa
cacataatta aaaagaaatt cctttaaaaa tccaaaattc tgttatgcct 155100ctctagccag
ttagagacag acagcagcaa tgtgcaatga cattatttct ataataacaa 155160gtacagatat
aaaagaatcc tcaggaagct gtagagaagc cgaagactct tcaagataat 155220gtgacattat
ctgaagtgca ggagggcaca ccgagacgtg ggctggggac agcacaacat 155280ggagaactag
ctcctttatg tgctcaatca aaaagttccc caacatttgg tctgatacag 155340tttgactcat
ccctactcac ccgtcgtgtg ggctgatcct gttccaggcc agagatcgca 155400cggctgatga
gtccttcaac agtggtcaga gcttgtggta aatgaaacat gagacaagtg 155460agtgctgacg
tgctatcact tgtctgtgtg accctcaaca ctttccctga actctgcagg 155520cctccttctc
ctcatctata aagctctaaa ctaagcacac cgtggtctgt ctcactactg 155580gactcttaag
agatttaatt agacgggcag tggtggtgca ggcctttgat cccagcactt 155640gggaggcaga
ggcaggcaga tttccgagtt tgaggccagc ctagtctaca gagtgagttc 155700caggacagcc
agggctacat agggaaaccc taaaaaccaa caaaacaaaa caaaacaaaa 155760caaaagagag
agagagatta actataactt tttactcaca ttaaaacatg aaaatccact 155820ataattaaat
gaccaaacac aagccactag gcgtgacctg gaccaggctt tgaaagaaaa 155880taggaaacat
ctcagcttgt gaacagctca cacacctcac acacctgatc ttaaaactca 155940cctcccttct
ggctgaaggc tggaatctca aaatccagct cggggatcct tgtggtggca 156000gagtctgtct
ttaccacttc tctgttcatg tcctggacag aaagcaaacc gttctagcta 156060aagaggtcag
caataaagct tgggaaataa ccagaccatc tctccatcag atgccaaccc 156120agatctttct
tcttcccgcc ttccattcag aagagtccaa actacttcag gatagtacac 156180atggtgtcag
cctgactacc cagaaggtaa gaacaccacc cacaaagccc agctcttcca 156240cataaatccc
atcactccca caaaattcgc aaagcacgtt caccactcaa agcagcagaa 156300ccgaggccag
caccaccgac accactgtca aaggacgaca ctaagggctt gggacaggtc 156360tggtgaaggg
ctgatggtcc gattgggggc tctgaccccc agtgcgctct ctgaaaccgt 156420gggggtacct
tctctggtct gcgctcacct cttggcttct cacggtcaag gtgtagcgca 156480ctccctggtc
ctggatcctg cctgcagact ggatctccgt gttgttccag ccacagtgtt 156540cgcaggaaaa
ggagctcacg atgatttctc taaagaaggg gatcttggtg agcagaagtc 156600gcgtcgtgcc
ctagggaagc agaagcggcg ttggggagaa tgacttcagc ttgtttacac 156660cctgtacgcc
agagctgcct ctgggtgcac ggctgggtgg ttccccgggc tcagactcac 156720gttccggtaa
cagttcatgc acagtgactc gatctcggtg ggctgttgct cctcatcctc 156780ggcgctgagg
ggccggaaca aaggcccggt ggctggtgac gcagccgcag cgggcgaggg 156840cccgacggcg
gcccccgggt gtcccggctg cacagccccg ctggcagaca tctccccacg 156900cgttgctccc
gcggcggctt ccggcttccg cggcccctgc gacctcactt cctccagccc 156960ctgttcccgc
cccttcttaa agaggccgca gaccctgcgt ttcctaggtc agtctctgac 157020aaagacttcc
ggttcctaga ctgcacttcc gtaactagag aagacccaca ctgggctgga 157080gagatggctc
atcgggtaag agcactgact gctcttccaa agatcctgag ttcaaatccc 157140aacaatcaca
tgttggctca caaccattca taatggggtc tgacgccctc ttctggtgtg 157200tctgaagaca
gctactcgtg agtagctcgc tagttgtggc ttctctatac gggtagcctg 157260tttgtcccca
ggactccagg tctatgtaaa atgccccggt tgctttggaa tcgcctaggc 157320tgtgccccca
cgggctggtg agatggctca gtgggtaaga gcacccgact ggtcttccaa 157380aggtccaaag
ttccgagttc aaatcccaac aaccacatgg tggctcacaa ccatcggtaa 157440ggagatctga
ctccctcttc tggagtgtct gaagacagct acagtatagt tacatataat 157500aaataaaata
aataattaaa aaaaaaaaac tgtggccaga ccttgcctgg gtcccctctc 157560ctgttatcta
gcttctcccc tccctgactc tctttccccc agctcctcac ttctgtcctt 157620ttaaacaccg
cccctaactc taaatacact gctcttcttt ttactcattt ttctcattcc 157680ccccaccgca
ttcgctgtct taatctctcc ttgtttccta acaaaacacc ctactttatc 157740gggttttttc
aaatttcctt tctagcgctt cctctctaag tcttggacca caacccagtc 157800acatggctga
cactgactct atctacagga ttgagggtaa caagggtgtg gttgcgtgga 157860gtgcagcttc
acagaggatc tgtagtgggg aggtatcgag catcctgtgc agagaaggct 157920gagctgggaa
gaaagggtgc tgagctgggc tttccttccc cgcccctgtc ttgtttcact 157980ggtccctggc
gatctttgat atctgagtga gtgtgtatac gaaagagagt taagagttct 158040taggtctccg
agcatgttgt taaccctagt acttaggaga cagaggcaag ttgatctcta 158100ttaatgtgag
gctaacctga tctacataat gtattccagg ccagcaaata ctctgtagtg 158160agatctgtct
caaagagaga gtttttatca atcccaagaa gagagtcaag caggcatgag 158220gaatctggaa
catgggacca agggtaaggg gatccttcag ggatttcagg gagagcatgt 158280ttccccatta
cacactccat cacatgttct ctgcatcatg ctctcctcct gctcccttcc 158340aacaaaagct
ctcatgacag ccctggggag acaggagttc ctctccgtgg accaactgta 158400acagccagca
ccaggctgcg agaattaatc cacgctgtcc tgtgatccgt agactgtgga 158460acaagacagc
ctcctcccca cccaacccca tcaaatgtga cagccattgt ctagccagga 158520gtcctacggc
agaactcgcc cagagtggac caagaatgga aaagagacag aaagagcaag 158580tgaggggtac
aagtggatgg tgggtgtgtt ctgagacaga ggggaaacaa ttgctctcag 158640acatggtcca
atgagagtca cgccagacca acaacgttcc atcacgagca tctatttcat 158700tccaaccaaa
agtcagttcc accctgagag tcaggaggta gggactgtat gatgaggaag 158760gcacacagtt
tgttctgtac aggatttttt tagaagccct ccttcatcgt gtggatggct 158820cagttcctta
tctggattca gagttctcta aggaaatagg ggctctgccc ggtcccatca 158880ctggacccac
cagcaggacc actggcaggg acgtacacac tccatcacat gttctctgca 158940tcatgctctc
ctcctgctcc cttccaacaa aagctctcat gacaaccctg gggagacagg 159000agttcctctc
catggaccaa ctgtaacagc cagcaccagg ctgcgagaat taacaggagc 159060ccaactccag
gttgtagtgg catgggtttc cagcacggtc aagcactggc ttgcggtcag 159120tcaccccaca
caccatctcc cactcctgtc acctcactct tgctacttag gattgccaaa 159180tgagtaccag
aagctgggtt tgcaaagcct actgagtgta atgcccctga gtaggggagt 159240tgaggaggct
gggtaggttg ggacagcagc acctttggtg gtgtgcagga ccctccaccc 159300tctgcctaat
agaccatgct agcggctcag ggtccagaca atgagctgga gggttaaccg 159360gagtgaccct
cagggtcact caaatgacta tgaccctggt cttgaaggcc ataggcaata 159420tcttcccaca
ggtcgtccag tcggctctgc agtctgctca gggccttatt actgtctgag 159480tgtcccagct
caggagcgaa ggcgctgtgg ctaggcgggg gtggggctag ctggtgctga 159540atttcctctg
tctcctggtc aatggcctga gtaaatgcag caatctgcag gtaggtgtca 159600tgccgaaaag
cctgcagtct ctggcggacc tcctcggaga gagcctgagg gtccagggaa 159660tctccatctt
ccgccccatc tgtgctgacg cggatgaagg cactgagctc atcgcgcagc 159720tggtccaggt
tgcgttggat gctggtgtgc aggtccttcg ccttacgtgt gagtttgtgg 159780gacagagtct
gcacgcagcg actgagtcgc gcggggctgg cagctgcgtg aggagcgaca 159840ctgcggtgca
gctcctgcac gtggtgccca attccagtca ccaagcgttc tgcgtaaggg 159900tggaagagct
ctttgactcg gtcggtatgg tgcagcactc gactctgcat gtcctgcagc 159960aggttcagcg
cctcgtccac gccccccagg agctgagcct tggtgtcttc tcccaccacg 160020cgcagctgct
cctgcagctc ctgcacactc aggcccacct gctccatcag ctccgccgtg 160080tagggtttca
actgctgcct caggccctcc aagttccagc ctacctgctg gtgcttcgca 160140gccatgtagg
gctccaggcg cgagctcact tcccccagct cctgctgcag ctgtttccga 160200atgccttctg
ggtcctgggc cagcagagga ggctccttcc caggccctct caagggtccc 160260agcttttcta
ggtaattgtt catattgtag aggtcttgct cgaagctgcc tttcaggttc 160320ctggagaagg
agaaagacag agaatcaggc cattagactg ctagcattga aatctccctt 160380tccccaaagc
tgtgggacac taatattttg cagaagccag gacaggagga gtggccccag 160440agcctggtct
ttagtcctga ccccagccaa cttcattgtt acattcagaa cacaaaatgg 160500cattcggtct
tacaatacca tccaagaagg tgtcacacac acacgccaag attcacacca 160560tcttgtcatt
ctgtggcatg ctaatctcag gtgccatggg caggagaaac ttggacaaga 160620gggtgcccaa
gatgactgag gtgtgtttgg ttctataggc agggctggtt ccttcagctt 160680ccatgttaac
cacagagcca agggatcatc ccacagtagg gctgtctcgt gccctcagca 160740cagccttgcc
caggctactt actcctgtgc cagcttctgt ggctggccca tcacgccttt 160800gctccaactg
ttttggctga agtagtccca gaggctcttc cgtgcctgag tgcttgcgaa 160860cactgcagag
gaagatgaga cagttaaggg ccaggcccct cagcccatcc tccatcccaa 160920acccacactg
cagtgggcca gaagacccac ctgcgaggag ggcgagggcc caagtgatga 160980ctgcagccat
gctttccacg atggcccctg agaaggaagg tagatgaagg cttgatcagg 161040aggagaggca
aagccaggga ctagatctag gaagcctggt ctagggggtg cctgccccaa 161100atcccgataa
cccttcccca gtgtgtaggt aacatcatgt caaaagctcc agagaactga 161160actaggcact
tgcggggact gggggtgggg gagtgaggca ggagggaaga gatgacttcc 161220tcagacaaca
gggttggatt gctccttacc tcggtcacaa agtagggaac ctggaactca 161280ggctgcccta
gagagatgac ccacccacct caatgcaatc tagctccctc gtttgcctgt 161340cttcctgcct
ccgagcccct tttagggatg aggactggta cacacaattt ctgctagcct 161400gtatctgcag
ctctctccta cctttgctgc caccccaccc ccaccatccc tgtgccatgt 161460aagctcacct
gctcggttct gggcacagag agcagacact cttactttat actctaggcg 161520ccagggagtc
tgacaacaat tcctctgagc aaacaccacg tggagggtca aagaaggatg 161580accccagctg
gttactagca cactcacctt ttccccttct cctggcactg ttggggttag 161640taagctcccc
agcctcaggg gggctgcccc agtagacaag tggctccctc gagcctttac 161700taagtgtggg
cagaacccac cccccaaatc ctgtgaccag caaccgcccc acttactgaa 161760tgactggcca
gccaatgaac actgcttgtc tgtccactgc gggccctgcc tttacttaac 161820tccccagcgc
cttctgcact agccagctgg ccagagggac agtgtccagg actggctaga 161880gcctgggctg
gccttacttg tcccaccatg gccactgtga cagcctgaga agagccagta 161940cttacagggt
tacagaccta tggcgcctag agtataagtg tctccaggat tgagctggag 162000aagtcaggtc
ctgttgaaga tggatggggc aagctgcatc tgggtcagag actttgggta 162060tcagaagtta
gtcccctcaa gagtcttccc tcacagggaa ggctgggctc cacccccttg 162120agcttccgag
gagggaagcc gggaagccca gatgtttctc ttatgacaag cttcttccat 162180aggcttgcat
ggacatacct gagtgcttca tcctttctct tcaacctcca gtcggtcccc 162240ctgcctccac
ccacacgctg ttcccgtcac tttcctcaga acttccctct gcccttcacc 162300gtgaccagtt
cagcctcctc ccttgtctcc acacaaaact tctgccatcc tcgatccact 162360tacctctcag
gcacaggggg atgtctgcct ataatcacgg cactggggag gctgaggcag 162420gagaattgta
agtttgaggc cagtctgggc tgctgtggga ggtcctatct caaacaacaa 162480aactaagaag
agaaaaagaa gctgccaagc ttcccactct gtcccagcac atgggtcgtt 162540aaagaagggt
tgtaagctgt acttacctaa aatatacata gtccagagat tgatctcaaa 162600cacggcataa
aacaggatta caggcgtgtg cttggaatcc tgagacaggg aaactgcagg 162660gacctgaagg
ggacaggaac tctagaatca gaatggagcc tctcacctag gcaagaatac 162720ctacaccatt
accatgtgct atacattagg tttcaaaact ggggcagaag gctgaggtgc 162780ctatttaaca
tatcaaagtg ggtctggccc ccacattcgc cctgttacag gaccctcctg 162840gctggcatac
tccaccccta ccctaggctt ctccaaccca gggagctgtt ctaccctata 162900taatccaacc
attttggtta cccacttttt ttgtgtcttt gtgcctcccg gttgcacccc 162960tctctccccc
ccccccttat ccctccccct ttcctctctt cccatgtggc ccagctcagt 163020ctggcctgtc
tagtctcttc cagatgtccc cacctctggc tctgctctcc catatatcta 163080ctataaactg
tctcctccac cacagagcta ggatcagtca tgttcctttc ctttcgcctt 163140ttttattttt
attttttcat tcactataaa ggctgctgac atagctacga tttctttctt 163200tatagatgct
ttatgttaaa atagagacgg agatagaatc tcaagcaggg actccttgct 163260tttacccaga
cactgcttga aaatctcaaa cactgtttac aacaaaggta ccctcctttc 163320ctatatcccc
atggactaga cttttgaatc aattattata ctgataagat agtaacgtca 163380aacctcatcc
aagtcctatg tatgactgct gtaaaaacag tgagccacgc ctctcttgag 163440gagcccacac
ctgaacacat cttacatttt tctgaatatt tatttctcct aatattcatg 163500tgttaaccta
tattataatg ttttagtaaa cttctggtcc agttctaact tactgtatca 163560gctagtctta
tttttatttt ctttttagaa gattgttctt aaatatctgt atatatgtgt 163620ctgtgggttg
gggggtgcct caggaggcca gaagagggtt tcagatcccc tggaactgga 163680gttgcaggca
gttatgagcc aaccactatg agagctgaga cccgaaccca gatcctctgc 163740aaaagcagcc
cgggctctat cctgctgagc catctctctg gccagccccc gactgttaca 163800acacttcatc
cctgcacaga agacttggtg cttgaagcat gtggaatggc ttctcttttt 163860tctggctgaa
cctagacacc tggtgaatgt aaggcatagg catgctttct tgtttgccag 163920caccgtgggg
cttcagtgtc gatgtgttca gggtggttgg aaatatgtgt gtatttgttt 163980tatgatctgt
gaaaataaaa tcagttttga tagcttaaaa ataaatgatc aagggctagt 164040gagatggctc
agcagttaag agcactgacc aaagccaggt gtggtggcgc atgcctttaa 164100tcccagcacg
tgggaggcag aggcaggcga atttctgagt tcaaggccag cctggtgtac 164160agagtgagtt
ccaggacagc cagggctaca cagagagagt tccaggacag ccagggctac 164220acagagaaac
catgtctcaa aaaaacaaca acaacaaaaa aacaaaaaca aaaacaaaaa 164280caaaacaaaa
aaagagcact ggcttctctt ccgaaggtcc tgagttcaaa tcccaccaac 164340cacacggtgg
ctcacaacca ctcataataa gatctgacgc catctcgcca tctcctggtg 164400tgtctgaaga
cagctacagt gtacttacat ataacaataa gtaatctttg gaccggagcg 164460agcggggcca
gagcgagcaa aggtcctgag ttcaatttcc cagcaaccac atgatggctc 164520acaaccatct
atatagctac agtgtactaa tatacataaa acaaataaat ctttttttta 164580aatcaaatgt
tggcaatttc atgtctaaca agatctattt atatgtaatt tagtatatct 164640aatgcataca
gcgttcttag cacatggacc tgaacatacc acaaaggcag ggttgctaag 164700aatgcaccat
attgatgatg ggactccttt gaacagtggg gaactaaaat attaaaccaa 164760agtaatgtag
aaaaagggaa ggagacatca aagtgaaagt gttctccagt cttgctttat 164820ccatggagaa
gataggaata ttgatcgtct cttgcttttt acatcaggca ccaccattaa 164880agttttaaag
agaatccatt aaatgagtag aaagaaaggg taacttgcaa actggtaaat 164940ggggaaaaga
gactaaagag cgtcgggttg gccgctagtg aaggtgctga ttgatcgcac 165000atgctcactt
caagctgttt cctgaaagcc caataaaatg tcattcaaat gctcccctta 165060gagaagcacg
aatccacgag gacagaaaag gagacaaaga cagccacatt ctggaaacgg 165120taaaacttct
cggcagtcaa acagtagtta ctgaaaacac atgaaatgat ggctttttga 165180aatggcaatc
cagaacgtta agaacttgct gggtttagct gttcagagac agcagcacta 165240gattcttctg
gacatatggg gagggggagg cagtggcacc aaaagagcag cacctgggtc 165300aaaagacatg
ggagaaacat gtctccttta gctctactta gtaaagtcag acacttgttt 165360tctagatgtc
tcacctcgtg cctggggtgg tggtgcatgc ctttaatcct agcacttggg 165420aggcagaggc
aggcagatct ctgactttga ggccagcctg gtctacagag tgagttccag 165480gacagccagg
gctacacaga gaaaccctgg ctcaaaaaaa gggggggggg ggaattctag 165540actacagtca
aatgctagtc ctaacctttt cctacttgtc tctgtctggt tgtttttgag 165600acaaggtctc
aatgtgtagc cccaactagc ctgaaactca tacccctcta gcctcaggct 165660ccacatatca
agttctgttt taagtgtttc aggtaagaat attatcaggg agaggtgggg 165720ccttcccaac
acaccacact gggggaagca tatcatggtg ggtccttcca attgcctagt 165780tctgggggag
cagagaaaaa gaactgagac tgcaaacacc cggaggcttc tgcgcaaacc 165840tttgtttaaa
acttttttta ttgagatgga aaggtaggga ggaagacagg gagggaagga 165900gggagtgtgt
gtatgttaga gtttctgtgt gtgtgcacgc tatcatgcac atagtgaaaa 165960cgtacagaag
tctctccttc catcatgagg gatccaagtc aagtccgcag gctggacaac 166020aaatgcctct
acctgctgag ccacctcacc agcttgcaaa tatcacttca tatcccaaat 166080tcatcagtta
ccaagaatct gaggatgcta aaggtggtga ctctgtcacc tactaaagac 166140agaaaatgga
gctagagaga tgactaagca gctaagagta ctgtctactc ctccagagga 166200ctcaggtgca
attctcagca cccacatggc agctcacacc tgtctgtgac tccattccct 166260ggtcatctgc
gggcaccaga cacatgaggt gtacatacat gtgtgcagga aatacactca 166320taggcataga
aaaaaaatgt aatctttttt taaatggctg aggggagagt tgagacaggg 166380tctctctaca
tagccctgac tgtcttggag ctcactaagc aggccaggct ggccttgaac 166440tcacaaagat
ccaactgttt ctgccttcag agtgctggga ttaaaggcat gtgccaccac 166500acctggttta
taattgaaaa aaaaataaag acaaaataaa atatcttttg aaccaaaaca 166560atttacttat
gatcacctta ccccatggta aaatctccac ttgttcatag tgggagaagc 166620aaagtctgag
ctgggaccaa gccatgaaca catgggcttc tgcggagcat aggtcattca 166680ggcccacgtt
atagccacat aatatattat gccacggtga gggattttct gtgtctgttg 166740tttcattcat
gtttcgagat gttagtttta ggtagatgct tagatgtggg attggtggat 166800taagcatgag
tgttgggttt gtttgatatt tctcactaaa ggaattgttc tcttttgtga 166860gtctataaag
cctgaataaa agtgtcttta gtttgtttgt ttgtttgttt gtttggcttg 166920gtttggtttt
gctttacctg cctggagtgg tagcccgtgc ctgcaatctc agcactagag 166980agacacacac
cacatttata cacataacac acacacacac acacacacac atacacatat 167040cacacacaca
cacacacaca cacacacaca cacacaccac taaatgaata taataacaaa 167100agcatacctg
acaatctgac acatgagaaa gtacatgaaa attcacgtac ttcctgacaa 167160tctgacacat
gagaaaatct attttcatgt acttctgctg ttcccgttcc tcccactatt 167220agtaaagcgg
gcatatattc tagtctgaat ggttatttga cctttctgtg actgttttgc 167280tcatctcttt
cccttcattt tctactgaaa atcttatctt ttatattcac agcatatata 167340tatatgatga
tctgtttctt attagtgatt gtatcagtca gggttttcta gaggaccgaa 167400actgatacaa
tgaaatatat atatgcacat atgcaccata tatgatatat atggtttact 167460acaggctatc
attcagctgg tctgacaatg gctgtctacc aattgaaagg ccaagaatcc 167520ggtagttgtt
cagtccacaa ggctgcatgt ctcagctggt cttcagtata tgctggaatc 167580acaaagaaac
aagctgtaat gccagtgaag gaatggattt gccagcaagg gcaagcaggc 167640aaagggcaaa
aacttccttc ttccatgtcc ttaatatatg ttgtcaccag aagatgtggc 167700tcaggttaaa
gatgggtctt cccatttcaa atgatttaat taagaaatgt ctttcacaaa 167760tgtacccagt
tgggttgacg agatggctca gcgggtaaga gcactgactg ctcttccgaa 167820ggtcctgagt
tcaaatccca gcaaccgcat ggtggctcac aaccacctgt aatgagatct 167880gacgccctct
tctggtatgt ctgaagacag ctacagtgta tttatgtata ataataagta 167940actctttggg
ccaaccagag caagcagggt tgacctacag gactacagga ttgaacagag 168000gtcctaaaaa
ttcaattccc aacaaccaca tgaaggctca caaccatctg tacagcgata 168060gtgtagtcat
atacataaca taaaaataaa taaatctttt ttaaaaatat acccagctgc 168120ttcagtttta
gttaattcca gatgtagtca agttgacaac ccaaaacaac caccacagtg 168180atataagttt
attggagctt gccagcaagt gcttccccga ccgagacaac tcgccagtca 168240ggttttctct
tactttgctt actatgtttt atttgtttgt ttgttatgta gagcattgct 168300tagtatttat
gccattaaat ttaccttgca tcattttgaa cttgggagtc agaattataa 168360caagactcac
tgcttcctgg cattaaagga aactgcctgc ttttttcttc atgtcccagt 168420gtgaaaggtt
tctttaatgg gtcaatcaat agtccagatg cttggcatag ccaggtgtgg 168480tgagacatgc
ctttaatccc agaacgcagg aggccgaggc atgtaaatgt ctgtgagttt 168540gaggccagcc
tggtctctat gtagtgagat tcccatctca aaaaaaaaaa aaaagcaaac 168600ttgagcaaga
atgttgacat atactttaat cccagcacat gggaggcaga agtaggtgga 168660cctctgatca
gatagagctg ccaagggact tctcccgcag ccatccaggc acctggagtc 168720cgtcgcagtg
tggtccaagt agacctggct ctggctcctg ctaggtctac ttctggccga 168780ccttggagtc
agccacgtga caagagttgt gcaatacaca ggatgggaga gttgtgggct 168840cacccagggt
tccacacaga tttcaagatc tgggggtgaa ggtgggagaa agcatatggc 168900agaatctgaa
tctcgtagcc ccctgggagg gcaatggcgg aaacagtgac agtggaagcc 168960atactgctgt
gaccccagga agtcagagat gccagcagtg gaatgtctgc caaggaaagc 169020cacatcctgg
gccacagtgg tggggctgcc caaaccctac atcatagcat cacatgccca 169080cagggtacag
gatctgccat ttcccttgct ggggttggat ctggccccaa tttccatttt 169140tatgtctcta
ttccatttgg atcagggata tttatctcac atcatatgga agtctgtaac 169200ttgtggggtt
tttttgtttg tttgtttgtt tgttttttgt tttttgagac agggtttctc 169260tgcatagccc
tggctgtcct gaaactcact ttgtagacca ggcttggcct cgaactcaga 169320aatctgcctg
cctctgcctc ctgagtgctg ggataaaagg tgtgtgctac cacgcccagc 169380ttatttttat
ttctattctt atagatgctt gttactaggt gtttgctgag agtgatgggg 169440aacactctgg
acttggactt ttgtataatg atagaactgg tgagaatttg aggactatag 169500gaaacatcct
atattgggca gtggtggtac acacctttaa ttccagcact caggaggcag 169560ggacaagtga
atctctgagt ttgaggccag cctggtctac agagcgagtt ccaggacagc 169620aaaggctaca
cagagaaacc atgtcttcaa caaacaaaca aacaacaaca ataacaacaa 169680caaaagagag
agaagaagaa agagagggag ggaagaagaa aaggagagag aaagagggag 169740gggttctaaa
tgcattttgt gtgatgagat ggatgtgggc ctttgaggga ggtcaggggt 169800aggatatgaa
atgcttttcc ccaaattatg ctttgtctcc agtcaatgta cagaggtttc 169860ggaggtggag
cttctgggaa gtgaccatgt cccagggttc taactgaatc aatggatcaa 169920ttcttagctg
gttgtaattt ttgggatgtg ggacttagtt gtgtgttgtg cctgtgaagt 169980gtccaccttg
tctctaattc ctctttctgt ctttctactt cttggctcct ctgaggtgaa 170040ccgttttgtt
cttctttcca tattggtcca cttacccaca atcccagaga cacagagccc 170100gttgaccagg
cactgaaatc ctggaaacag gaacccaaat caatcctccc tcctctagac 170160catttcttgg
acatttcgtc aaagcgatga aaaatcaaat tgggttgggg agatgactca 170220gctgggtaaa
catgaagctt cccaaaactc atgtaaacct gaacccatgt ctgtagtccc 170280aggatgggag
acagagactg gagaatgcct gcaagttagt tcatgggcca gctagtcctc 170340aagagacagc
tagagaccct atctcaaaca agatgtaagg caaggaccaa cagttgagac 170400tgctctgtcc
cttctgcctg tttgtgtcac ctgagcatcc ttactcacaa actagagcat 170460gcacatatgt
gcacacatgc acatgagaat taaacaacaa gaaaagaaac gttcattcat 170520gggctggagg
tgtagctcag gtgtagagag cttgactagc agacacaagc tctggcattt 170580catcctggca
ccatggaaac tggagatgct ggtgtacatc tgaagtcctc aaatttggga 170640ggtggaaaca
ggcggatcag gagtttaagg tcttcctcag ctatgcagtg agttccagtc 170700cagcctgggc
tctatggccc tattgattaa catgggaacg caaatatggt ccatggacag 170760catgctggtg
gatagcaaag gaacgccata atcaatagaa aattcagagt gatttggcaa 170820aagtcgggcg
tgaatcacag ccagatcaca tagtttgagg ccacagagct gcactgaaaa 170880gttagaatgt
tgcaactcct caggtctttg ccctcatttg taaaatgaag gtgataccag 170940tacccaactc
tagggctaca cactgaaata acgcttttta aacatgattt atttaaagtc 171000atgtggtgat
gaaccacatc tttagtccca gcactcggga gacagaggca ggtggatttc 171060tgtacattta
aggccaacct gccctacaga gctacttcca ggacagccaa gtgtgggaac 171120agggaccggg
aaatagggtg ggggagtgga agcggagccc acaaagattc cctgggattt 171180ggactctgga
gaccagcatc gaggtccagc tctaacttta ctgtttagta catatgctga 171240tatgcagttt
ttcagccaat tagggtacgt ttatgtatcc agggacaaat ctgggtgcaa 171300catgtgttgt
ttagctgaat ctgtcccatc tgatcatgag cctgtagggc aggtgcctgt 171360catccaggaa
gatttctgtg aaggccaggg gaaggagcca ccactctgcc ctctggtcct 171420gtgagttgtc
tcatggtgtg ccaggatgaa gcctatgtct cttcactctc cttcccactt 171480gttcctccac
caggtttatt tccactttcc ccacagccaa ggctgcaagc ccgtcacaaa 171540aataagtaag
taagtaagta aataaataaa taaataaata aataaataaa taaattttat 171600ttatttttaa
ttaatttatt attttggttt ttttgagaca gaatttcatg tatccctggc 171660tgaccaggaa
ctcacttgta gaccaggcag gcctcaagct ctagagatcc acttgcgtct 171720gcctcccgag
tgcaggatta aagatgtgta tccctaagcc gggcaagatg tgtttacttt 171780tatttcccac
gtctgggtgt ttctccaata tgtatgtaag tgtgctgtgt gtgtatctgg 171840aactagaaga
gaatattgga cccctggaac tggagttggt tgtaaaccat ctaggtgcaa 171900gacacagtgg
tcacatgaaa atacacaaga gaataaaacc tgggtggaaa agaggctctg 171960ccccctgcag
gtcagtaaga gagaaaagca gggataaata gggagttcgg gaaggaatag 172020aatcagttta
agtgggacta aaaggtcact gaaggagtgg taaggcccag gaagaagagc 172080ctgaggaaca
gggtgtggag ttcccagtag acatgaaagt cccagtggga cagcatgggc 172140agaaggaact
ggaactaaga cacatggtgg ggacagaggg ctcgcctctc tgggatatga 172200agaagcagca
ggagcagagg ccctggcaga agtcaggaag ggaagacaga gtcccattga 172260ggcccagccc
acaaaggaat gtgttgtcag ggtcagtgga aacaggaagg ggaggcctta 172320ggaaatggga
ggggcccctt gctcccagga gtgaggtaat atcctgtgga tttgggtgag 172380aagtgtcaga
catgcccaaa gtctatgaaa gcaacatggt cacagaagcc cacatggctg 172440gaaatggagg
gacgcatgct accgtgtctt ggagagtcat aagatacaac ccccaggtag 172500tgtaccagaa
aagaagttta acaagaagct caggggaagg tggcccaggt cttccaggtt 172560tcctgagtct
ggcccaggag gactggagaa aactgatgga tagtctcctt ttacattgca 172620ccctctgtgt
atctcttagt actcaagtca acactccaaa gcagaggttt ctctctacag 172680agaaaccagg
attcaaagag atgtcagctc ttgttcaagg tcttatcctg ggtcaatttc 172740aggcctatgg
cctctgatgt ccagttcagt tcactgcctt gtactcagag gctactcaag 172800agctcatctc
ctacccaaag cagcagctga aacatctgct cttctcagcg ggagaagcca 172860gtgctcaggc
acgaagccag ttactttccc gttgtcccac gatgttgatg attcagggac 172920aaggctgtta
gagacacatg ttgactaatg tgaatacagg aaaagaaacc cagggccagg 172980cagaggctag
ccagtctcaa gtcaaggtgc agctaccaag tcaccctgag actgggactg 173040ccctcttgtc
ccctcctcag tctccctctt ccctcaaact cctcacagtc agaagtaaat 173100ctagctacag
ctaggacacc aagttcccag acctccaaca tgcctctatg acctgtctgc 173160cctctgagac
catggtccac agagactgtg aagttacctc agcctggtgt ttatgccact 173220gacgcccgtt
gatggagcaa tgctaggtgg ggccagtgac gtcgactgat accacaagat 173280gtacccagca
tgatgaataa acaccgtgct ggtgtgccag acaagataaa tgttattatt 173340tgtgccactt
gtcttgagag agacccctgt gcaccatcac aggaaatgaa tactgagaga 173400gatgtcggtg
gagaccaggg caagaggcag agagaggaga accttagggc cagagatgat 173460gacaagacaa
cagaagatca tgcgctggta aaaaaaaaaa aaaaaaaaaa accaatcaca 173520gagtgagtaa
gaggtggcaa aggtgtagaa cccgaccttc accctggccc cgggtttctc 173580agaatcctgg
gaaggggatg gttcatccag ttacataact agcatagcca gaaaggagcc 173640atgccagatt
cgcagaagag ggtttcacca catcgcatga aagaaatggc ccagagggtg 173700tttgtttgtt
ttttatttat ttggatgaga tgtcgccatg tagccctggc tgacctggga 173760ctcgctgtgt
tgaccaggct ggcttcaaac tcacagggat ctccttgcct ctgcttcctg 173820ggtgcgggga
ataaagccag gagccaccac tatgcatggc ccattactat ttgtaagaca 173880aggtttcaca
atgttgccca agttggcctc aaactcttgg attgaagaga tccccactcc 173940cacccctgta
tagagggagg gtcttgagtc atgcagctgg ggatggagct cagtggatag 174000tgtttgcctg
ccacgcaggc cgtcctggct tcaatacaat gcactgccat gaatggccac 174060tggctcgggg
catagagcca gtccaggatg ttcaagcttg ggttcagtcc tcaagatacc 174120gagcagcaga
aacaaaccac gaacccaaac aaacaataag aacaaactga agcagcctca 174180tggtggcctg
actgatccat aggtagaaat aaacaggcct tttgagtata agatcttttt 174240tttaaaagat
ttatttattt attatatgta agtacactgt agctatcttc agacactcca 174300gaagaggcat
cagatttcgt tacagatggt tgtgagccac catgtggttg ctgggatttg 174360aactcgggac
cttcagaaga gcagtcagcg ctcttaacca ctgagctatc tcgccagccc 174420tgagtataag
atcttatgtg ttaaaatatt aaaaatgcat aaattaacca aaagctttat 174480atttgggtgc
ctctgtgtct gtctgtctga ctggctctct ctctctctct ctcgtctccc 174540tctctctctt
tctttgagac agggtttctg tgtagctctc ataagctatg tagaactcca 174600ctcctagtga
ttcctctgcc tctgcccctt tccgagttca tcttataaaa gaacacaata 174660cagaaaatgt
gaagatacac ataagcaaat agaagaccgt cactcataat tatactatca 174720gcaattatat
attcttctat attatttatc taggaatatg ttcacataaa catttttatc 174780atagtgtgtg
tgtgtgtgtg tgtgtgtgtg tgtgtgtgaa gagccagaga gagagagaga 174840gagagagaga
gagagagaga gaatgtgtgt gtagatgcag gtagaggctg acatcaggac 174900agatgtgtct
taactagcct ccaccttatt ttttgaagta gtagctctca ctgaacctgc 174960ttgattcaac
ttggcttcca gacaacgagc ctcagaaccc agagctgggg ttccagtgtg 175020tggctactcc
tggcttttcc atgacttctg ggactccagg ttcaggtatt tgtgcttgtg 175080aggccgacac
ttttcctact aagccatctc cccatcccgg tataactact ttttatttta 175140gtgtacacac
acgtacacac acgtacacac acacacacac actagaggac aacttgtgtg 175200aatcatctct
ctccttccat catttccatc ttgtgggttc tgtggatcca actcagatca 175260gcaggcttgg
cagcaagagc ctttatctgc agagccactt gctggtccgc attgtggctc 175320ttgatggatg
agaatgtggg catactgtga tttatccggc atgctcctct tactgcattg 175380tttctaagtt
ttagcgttac taatagggtt agagagagaa caattgtaac aagggattct 175440gagccctctt
ttggcttctg ttgggtcctt gcagtcatgg ggtacactca caacacagtc 175500acatacatac
ttataaaaac tttaaaaata ataaaattaa cgtataaata agattataat 175560gaacattctt
agtgagatat atgtgcttca tgattatttt cctcagattg aaaggggaag 175620tggaagaaca
ctgtgctgga caagctagat cctctccatg aatcctttgc cgcaagtacc 175680ccagccctcc
caggcgcctg gcaccagcgg cctccatact aaaggagaga tgcagagcag 175740agcctctggc
agtctgtcta ggccacttct gtagacaagt gtgcagaaat ggctaactga 175800ggacaatacc
tgctctcact tggggctgag ctctcctaaa aacagaggag aagccaggcg 175860atggtgcaca
catctttaat cccagcactc gggaggcaga ggcaggtgga tttctgagtt 175920tgaggccagc
ctggtctaca gagtgagttc caggacagcc agggctacac agagaaaccc 175980tgtcttggaa
aaccaaaaca aacaaacaaa caaacaaaaa aaagactcag ccatatcaaa 176040ctcaccagcc
ttcctggtaa gcgctttgcc agccgtctcc tcagcctgat cttgccaatt 176100ctgtagatct
gtcaggaggc tgcaagcaga agcgctcgtc atgtaaaggt tgggctgagc 176160ctggggatat
ggtgacatgg tctgcttcta aggcagctca tgcatgtggc tggcaagttt 176220ggggcagagt
ttccattcat ctctttaggg aactctccat aggactgctg gaatatcctc 176280agacatcatg
gctatcttcc tgactgcagt ggttccagag aaagagtcag ggagccgcaa 176340tgccctctac
acccctcctt tgggcacata cagtctgtct tccacaacag ctccttgatt 176400acacagacca
cccaaactgt gaataccggt atggaggagt gcagggacca tcagtgaatg 176460aaggtgatta
agcagtgtaa ccccacccac ccccacacac accaagaaat gactaactcc 176520ttactacttc
atccaaatga acatgcacat aagacttgac gagaaaagat gtgctaattc 176580cagtcattat
tgcttgaaca aatgtttatt gagcacctac tagtggaggc tccaattaag 176640ggaccagtct
acagttaaga tcagggacac aaggcagtac cctccagccc tacatgggtg 176700tgacagttct
aagtcccaga tctttaatcc ctagagcact agcccaccat atcagaacct 176760ccttcccatg
ctcggaaatt ccagactctc taatgtgctt ctctgctctc agctgctcgc 176820catccttgcc
aagaccacca ggaccccact ctatttgttc tcagacatag acatccccag 176880agaacctcag
gctagtttct ttctctgaag agcaggcttg gacttccagt gccaacagca 176940gaaggccagg
atgcccccag gcaggagctg cttttgaccc tgccagggaa atctctcaaa 177000agcccactga
cctgaagaga aggtgggcga catgctagtc catcagtcct accttggcta 177060gggcagccct
gtggggaagc accaggatac tgcttctttc agattctaga agtcacaggc 177120ctgtgaggag
gggaaggaca accagggact caaggtcgtc cttagctaca cggtgagtgt 177180gaagccatcc
tagatcctgt gagactgtag agagcccggg gacactgctg ggaagaaggc 177240gagttgaagt
ggctactgtg aaacctatgg ttcttccttc cttaaaacta agcagagagg 177300gaggagagac
agcccagtgg gtaagagcac tggttactct tttagaggac ccacgttcga 177360ttcccagcac
ctacgggata ggtcacaatg gtctggaact ctgtttcatg catgtggtgc 177420acagacatac
atgcagacaa atgtttatac atttaaaata attataatta attaattaat 177480taattaatta
aaaaccagcc acggagagcc tggagatgtg gtcagtggtt acgaatgctg 177540gctgcacagt
catgaggtct gcagttcggt ttttacttgg gagccagaga caggcggatt 177600tctgagtttg
aggctagcct ggtctacaaa gtgagtttca gaacagccag agctatacaa 177660agaaacactg
tctcgaaaca aacaatacac acacacacac acacacacac acacacacac 177720acacacacac
acacacacac acacacatac tgtagctgtc ttcagacata ccagaagagg 177780tcatcggatc
ccattacaga tggttgtgag ccaccatgtg gttcctggga attgaactca 177840ggacctctgg
aagaacagtc agtgctctta accactgagc catctctcca gcccagagtt 177900caaatcttag
cactcaagta acaatctggg tgtccaccta ggctaatgtc tccagctcca 177960gtggggtgaa
gacaggagga tccctggggc ttgctgtctt tcagaacagt tgagaaaatg 178020ggaggccagc
ttcaggaagt aaccctccct caacagaaaa ggtggccagt aacagaggag 178080gaacaacagg
ccctcttctg gtctccatga aggcacacag gtgacatagc tgcaccctat 178140gtgcgtgcac
acacagagag aagttgacga atagaccttt ttaaaaagtt aagcatagaa 178200ttaccacatg
acccaccagt gtctcctcca agatacacag tcggaagcac aaggagcagg 178260gactgggatg
gctctgagtg cagctgagtt catcacagta ttcacaatgg ctgaatgagg 178320atgtgttttc
tgtctggggt gtgttgctac aattccttcc ttgggaaaaa cataaatact 178380actcctcctc
ttgaggtcca gtgactccaa gttcactgtg gaaacaatca gtttcctggg 178440tttatttaca
aagcaatgtg agaggagtgc cagcagaatc ataggtgact ataaaatagc 178500catgctgaaa
tgtcttcacc cagcagggat agtgatttcc ccatggctgt gtagaaggaa 178560ctcctaccct
taaccgtacc atctctactg gctagctact cttcaataca acatgcagct 178620atgcagtgat
ggtacactcc tgtaaccctt acacttgcga agcagaagca ggcagatctt 178680tgagnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 178740nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnncttgct tcttncatcc 178800acctcntttc
ttccttcttt cttccttctt ccttttttct ctttatgaaa tagggtctta 178860ttctgtactg
tagtccagac tggcttgaac ttgctgtgta gatggtgcag gggccttgaa 178920cttgtagcag
tcctcctggc tgtgcctcta catgctaaga ttgtaagtgt acaccactgt 178980ctctagctaa
gatttcttgg aaatcttgat agaattgtta tataagccag cactcgggag 179040gcagagaggc
agacaaatct ctgggtttgt ggccagccta gcctggtcta cagagtgagt 179100tctaggccaa
caggaacagg atggcctata cagagaagcc tgtcgaagga agaaaggaag 179160gaaggaagag
gaaggaaggg aagaaggaag gaaggggggg ggagagggga aagggggaga 179220aactgggcaa
agggaagcaa gtcaccttca tttcttacat accagttgca ccttcatgct 179280taaacagtga
tcatcattct cttctcagtg tttttctcat ccacagacta atctccaggt 179340cattgaggac
atgtctgtct tgtccctatt gttctgagag cactttggtg gagcatcaga 179400cattagaagt
acttttctat taccacatac atctctcagg gttacagctg taatgtctct 179460ggtcaggtga
attatgttaa tctcttagct ttgacctaag aaggcatttt tttcacttgc 179520ttataactcc
gaggctatac ctttgagctc tctaaatgcc actcccacct tccgtattgg 179580gtcatgtctg
aattatattt atcattgtgt gtgtccacga tgaatgtgtg tcactgtgca 179640tgccaacggg
cacctgtaga ggtcagagga caactctgtt gagtcggttt tttccttcca 179700ccttcacatg
gtttctaggg accaaactca agttaccaaa cttgctccat cacccactga 179760gagccttctc
cctggcttca tagtgtttgt ttgtttgttt ggttggttgg ttggttggtt 179820ggttggttgg
ttggttggtt gattggttgg ctggctgtgg ttgctgttgt ggtggtggtg 179880ttggtggtgg
tgattttgag acaggatctc actgagtagc agtggctgtg ctccaatata 179940cagagagcca
cctgcttctg tatcctgaat gctaagatta aaggcatgtg ccatcatacc 180000tggcccttga
tttttaattt gaaaaatact gtatttaaat actgggtttt gggctggtga 180060gatggctcag
tgggtaagag tacccgattg ctcttccaaa ggtccagtgt tcaagtccca 180120gcaaccacat
ggtggctcac aaccatccgt aacaagatct gacgccctct tctggtgtgt 180180ctgaagacag
ctacagtgta cttaaatata ataaataaat aaatctttaa aaaaaaatac 180240tgggtttcca
tttggtatca ttaggttctg tttaaaaatg aaagaggtct ttattcattg 180300tgctctataa
aaggtgtact aaaacttctg agtaatatgc tcacctgcaa gtattgggaa 180360cacactgagt
ggacctttgt ggctctaatt tgttgtgact tagaattctg atgatggcat 180420gcatgttact
attcctaaca gtttcggtgg gtattgtcta catgtcttat agaaactgtc 180480tgatgacagc
accttttaaa atggactcat ttaaacaagg agacttctgg tagggctttt 180540caattttgct
ttcttatggt aagagtgggg ttgccaggca gtggtggcac atgcctttaa 180600tcccagcact
tgagaggcag aggcaggccg atttctgagt tcaaggccag cctggtctac 180660agagtgagtt
ccaggacagc cagggctaca cagagaaatc ctgtctcgaa aacaaaacaa 180720acaaaaaaaa
agaagaagag ttgggtagta gtatctgcag tagtgttgag attggccaat 180780ttggtgatcc
cacctgctag tgcatgttgg gaaaacccca taagttcttc atcataaatg 180840ccatttcccc
atgaagggat tttccctgaa tgtgtgtttc aggccgtgag tctctcatta 180900cttctttgtt
agcttctagt cagtaagttc agccaggggt tgatgcaaat gctaaacact 180960aaggattccc
ctaacttttc ttcaccgtga actcattgat tcctggaaga tttcaaaatc 181020acctcatcag
tgctgtgtgt gatcctacga tccacactgc cttctgttgt tttattcatt 181080aaagaagtaa
taatagcaac caatgcttag tgaatagtct tgtaggcgac ttaaagaact 181140agttctcttt
ctttgctgta tgtcatatta gcagcctggg taacaacccg attcttattt 181200atataacttt
ttccactcat tttggtcttt attatttttg agtcatctct aacaagcccc 181260ctttctctgt
aagtccatgg agatctcaga caaggaccag agttaactgt gcgttggggt 181320gtttgtctct
ggttgtaagt tgtcctcaga agattacagc tttgacagaa tgagggatct 181380tgtctcagtg
cttcctggtg cagatggaca cttggaaata cggatatatt tccaatttat 181440tgtcctccca
agctatactc tccatatata tatatcttgt tgagtctggt agacctctta 181500aatctttccc
tctgagtgtg tatatataca tgtgtgtgcg tgcacacaca cacacacaca 181560cacacacaca
cacacacaca cgcacgcagg aagggaagtc tagctctcca gaaggcttgg 181620ctgtcagctg
cattgctttg ggagcaccga gaacactgac actagctgaa ggctctgccc 181680cgtctgctca
catctgcttt ggattgttcc ttggtcaacc aggaaagatg tccttgttat 181740tgctctgaag
tggtggactg aacaagaaaa tttgctcttg gaattgtccc gatttttaaa 181800ttagtgccac
cagccctcct ctcttttccc accatgtttc acatacccag ctaatgatac 181860gcttatttta
ggatacagta tcactacctt atatagcctc aggcgcctca tctcgcctag 181920aacaaagagt
ttcaaggctc aaaatcaatc ttggcctctg gtatttaaac catcctaggc 181980gatgaacata
gggttcaaat taggcctctg ctttgtatta agagaaaagg atgtaaattg 182040ccttttgagc
ctgcagacaa atgctaacta accggggtgt tgggggttgg aaaagacact 182100taacaaatta
agttgagttg cttaggagtg gagaaataaa tgaccatagg ctccacccat 182160atggcttctg
ctgtgttggg tgtaactgct gtatccagtg taaccaattt cctttgtgtg 182220tgccaccaca
cgtgtgtatg ttcatgtgtg tacaagtggg catgtatctg tgtgtatatg 182280taagccaacg
gatttcactg ggaattgttt aagtgttatc cttctagcta cctatgaaca 182340cagggtctct
tactggagcc tgttaccccc tgattaatcg gggatgcctg gccagcacac 182400ttccacaccc
gcctccttct ccccagcacc ggatttagaa acatttgtca ttacatttag 182460ctttggggaa
tcttaaactc aggtcccctt gcttgcatcg caagcatttc ctgaatgagc 182520catctctcta
gcccttagtg gtctctttct gttatgactt tgatttcttt tgtttgtttg 182580tttttaaaga
tttattatct atctatttat ttttatatga gtatactgca gccgtcttca 182640gacacacact
agaagagggc atcagatccc attacagatg gttgtgagcc accaagtggt 182700tgctaggaat
tgaactcagt acctctggaa gagcagtcag tgttcttaac cactgagcca 182760tctctgcagc
ccacgacttt gatttcttag gtaaaaatct ttatgacatt tatcacctct 182820ggttgagtct
gtaggccata aatcttttcc tatcctctga aaagggactg ctggctgtct 182880ccatctatta
ttcaaggcga tgctttaagc tggacatcca gtgctcacct gtaatctcaa 182940catttgggag
cccgaggcag aagaattgaa aattctccaa cctggtctca atctcccacc 183000ccaaaagtaa
tattttaaca tctgtatatt tgaaagagca tagtgaattg taggttcatg 183060tatgcttacc
cttggaagtg taaatgaaag atttctaaac attgcagata taaccttccc 183120tctaagatac
tggtcattct gaaatcattt cttcccgggg cttgttttct gtatacagtc 183180agcatatcta
caattatgct tttcccttta tgtcacctca agtatccgat ccaggatgct 183240ctgtaaaatc
accgtgtgcc atgttgcatg caaagcaatg tacaagtaca ggtaggaaga 183300atctttgatc
caccctgaat tactgcatga atatccaaat tgctcttcca tatccaaagc 183360ccccttcatg
acgttggctt cagcgctgca cacctcccgc tttctcgggc ttttaggatg 183420ccctgtaact
ccaagtattt acttgccctt gtgagctcat cagatcccat ttgatccgag 183480tctttcctct
gcttccgttt gtatgtgact tgtatggttt cactgtggtg acattgcacc 183540agagtttagt
ctatggcatt ctccatcctg ggccacatat gcctttcagc cataatagca 183600gagataagct
aaggtcactg tctagtgagc ccagccgcag agcgacacgt cctggcactc 183660caggttttcc
aggtggtact ggttctgggg acgcagggac cttttctagc acagaacatg 183720tacttttgca
gaagtggctg ggctatgctt ctgctaactc cagggatatc atgcatgact 183780taaaaagtat
agtcggaaaa atgtttttaa aagttctgcc aaaatctcat ccacttttag 183840ttatctaatt
ttttaaaaac tctatcctga gttttctttt ttcttctcgc tgtccatttg 183900acttgaccct
taagctagac atgctgaaag aaggatgcca agtccatagt gacagacagt 183960ggggagtgga
tggacgcctg gtgctgggat ggtgcttagt acagggaggg cttctttctg 184020tggtaaagta
ctctaaatcc accctggtta cccaattctg aacgtaccaa aagccactgt 184080cgatgcccct
taattagatg aaattataaa gtgtattata aagagtggat ctctgctgag 184140catgtatcaa
gaagcacagg atggtctcat cttgtcttat agaacttctc aaagccgggc 184200agggagggga
gggaagcaga ggcccatagc acccagcatt tagagctgag ctcatttcac 184260ctgatgcagc
tgtgcattct gggtagtgcc acaagcccca cgcaacaccc agggcagtcc 184320cttcatagtc
tcttgtattc acttagcaag caagttctga gtgctctgtg cttgatcatg 184380ttcccctcca
cccccattca gtttccagtc cacttttctc tctttacctt cccagatcac 184440ctaagtgtga
tcttgggttt gttttaggtt ttgtgtgtat gggtgtgtgg tgtatgtatg 184500atatctacat
gtgcacattt gcacctgcac taggaggcca tcagatgtcc tgctctatcc 184560ctctccattc
ttttgtttga ttggtttttc aagaaagggt ttctctgtat agccctggct 184620gtcctggaac
taactcgatg tgccactact gcctggctcc ctctccatac tctttctctt 184680tctctctctc
tctctcaaga tttatttatt tatatgtata ttattaagat ttatttattt 184740tatgtagctg
tcgtagacac accagaagag ggctcttaac ctctgagcca tctctccaga 184800cacacacaca
cacacacaca cacacacaca cacccattct cttcagacag ggtttctcac 184860tgaccctgca
gccgacctgg caaccagcaa accttagatt tccccctcct cagcaaatgc 184920cggttggcta
cactcagcct tttagtgagt gcttcagatt tgaactcagg cttgcacagg 184980aagcaggctt
catgctgagt catctctcta gccccctgct tcctttttga gtcatccctg 185040agatggtgtc
ccttctgtag ggattgtcat actgcagtat cccctgcaag tcctccagac 185100actgatgttg
aatgagtgtg tgaagagatg gaggcattca tttagagtcc tgtatgaggt 185160gctgggagta
tgcagcagta ggcagtgtga gtagcagaaa cagcagctcc tgagcccatg 185220tgcctttgga
agagaaatca taacttttta ggtacaaagt aactgatcaa accctggctc 185280tgtgccttgt
tgttgttgct gttgttgtaa atcttgttga tatttctgac ccaagccagt 185340gagaatccat
ccttgtttta gtctttgctt tatttttgtt agagtttttc ctcctgtgtt 185400ggttgatatt
tagtttattt cagttgtctg tcctataaac agtaaaggct gctcacccac 185460gtcttcccgc
ccctgcttca accacacatc ccagggtccc cctgctactt cactaaactg 185520ccaacagttc
tgaaaaatag ccctctgctt gaagtgtgca gaagctgccc acaacggtaa 185580gcagctaaga
gaaaccagag cacatatttc ctccaactca ttttttttcc agcccctcaa 185640gtatttgtta
gagggagctg agttttcaaa atgagttcca atgttcccgt gtgttaataa 185700tttgaggttt
ctcctgcatg gataatttaa atgttcaaaa ccaactcatg ctaaagttaa 185760atgcacattg
aactagccgt actcctagct taccatatac atggcagtga tggagaggga 185820tgtgaggtaa
agagccactg gcagggaaga tggccacaca gtgctaagga aacctcgctt 185880tacagtgatg
cattgtcagg aaggatgctg ggcctgcccc tgctaggctt ggaaacttaa 185940actgcgttta
aatcatcttt cacagcacca ccacaagtgt cccactgcag attcttgtta 186000gtgatgccag
cgagccctcc gcactgagct gcctgggctg acctcaaact tcgagtcctc 186060ctgacttagc
ctcacctagc cggggttaca ggcttgtgcc atcaagtcta gggtctgtta 186120ggatttttaa
caacctatcc tacttgctta tgaagagttt ggacaatttt gctcactgtg 186180tgcagactgt
gaggtgtaat tggacattga aaagattggt ggtatattct tctagtccta 186240gcactcagaa
agtcaaggca agaggattct gagttagaga ccagcctgaa ctacaagatt 186300tccttcagct
taggctgcct gtgtggccat agggagactc tccagcaagc catcaattgg 186360tatggcttcc
agctgatcca tgggcatggc ttccaatgtg ttctccttca gaagcagcat 186420ctgctgtttg
tttttgagac atgatctgac tgtgaagtcc tggatggcct ggaacccata 186480atggagacca
agctgacctc aaatccacag ataaccaatc ttcctctgcc tccagaatgc 186540tgggattaaa
ggcatgagtt accatgccgg tccataagca ctatttctta cacactcact 186600gtgctcgaag
aaatgctaag tatcatgaaa gccaggaaag aatagtagcc ttttttaaac 186660atgaatgcta
ctctcccacc ctcccatctc ttcggcccct ttcatgtccc cccactcctt 186720ctcaacttat
ctcctctttg taccggtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgagag 186780agagagagag
agagagagag agagagagag agagttactt ctgaccactt gggattggat 186840aacccttggg
gcctcacctc tgtcgaagag aagactgact ctccctctct tggtagcttt 186900aattacatgc
agctcttcat ctagaggtgg ggccttgtga gattccctcc atccatgcat 186960gatggcgtgt
cagctgtgtg tgttgtcatt ggacaggtct ccttcagcaa ctctaataag 187020tagttctaca
gaaactacgg agaaagaata gacttctcta agagaggtag agtgttttta 187080aagctgaaag
aattacacac acaagataaa gagtcacagg ggagtacaga gaaaggggga 187140gggggattgt
cttagtcagt actctatttc tgtgaagaca ccatgaccac agcacctctt 187200atgaaggaaa
acatcttgtt ggctggcttc agaggtttag tccattagcc ttagggcagg 187260aagcatggca
gagcagaggc agacatgctg ctggagaaag agctgagagt tttacatctt 187320gatccacagg
cagcaggaag ttacagtgac tttgacttct gagacctcaa agtctcaccc 187380cctagtaatg
cactttctcc agcaaaacca cacccatgcc aacgaggcca cacctcctaa 187440ttgcatcact
ccctatgggc ctatgcaggc agtttttact caaaccacca cagtgatcta 187500agagacttca
caacagggtg tttatttctg ttgacaaatg gcactgtttt ggctgtatca 187560gaccctgaac
taaacccctg gtgatcagta agctactagc ttcagcagct tgggtgagag 187620aggttggaga
tagaggttct ggtaggtggc cattgacgca gcagtgtgag aaggcaccag 187680tcagtgttca
ggagcgactg acacagtaat ttaactggct catttttgtg aacctttcta 187740tcgtatatca
aagattctgt gaaaagatga gaacaaataa acctctttcc tctccactca 187800gtagtcagta
gaaagcttga acacatcata tagctaagaa caatgtaagg cagagtggag 187860actgggatgt
cagagaataa acaaaaggct ctgacaacca aaggaagcaa ctgatatggt 187920attttctgct
ggaaatcagt taaagcttca tacaggaagt aatatttgac tgcaccttga 187980aaacggatga
cattttaaag gtgggagaga caggaacagg cctggcacag acaggaagta 188040tataaagaaa
ggcatataaa cacaggatgt gggccctcta gtactgaaga ttagccaggg 188100gtactcagga
gagctgggta gggtggggct ggctgtgatg gaacttaatg acaatgctaa 188160aatagagagc
tgcctctttt tttttttttg agcaaagaga taacaggatc tgattttgta 188220tggcagccat
tgagctctga gtgaatagct taggaggtgt aaaaggtaag attctaagca 188280agaggggctg
gagagatggc ttagcagtcc agaacacttg ctgcttcatt gtgaggacca 188340gagttcaaat
ccctgcacct atgtgagaca gctctcaaag aggctgtaat gccaagaaat 188400ccagtttcct
ccgctggcct ttatgggcac tcatacaaac ttgggcatac acccacatgt 188460aaaagtattt
ttttatcccc tgatgtaaat gttgcttcgg aggctattgc ctctgtctgc 188520taacctagtc
ctggaagctt ctagcctcag tacgacctaa tctaggccta gagtgttttc 188580agcccctgag
acttgctgct gaataagctc accctttcta gttctttctg agctgtagcg 188640caaacactct
ccaagctgac tgattcaatc tggctccccc gccccctccc tccctctcct 188700gagagttagg
catatcctgt tctgtcaaat cattctctga ttcatcactg tgtcactttg 188760ccactcaatt
tgacatcact ttccacatgg gcacttcctt ccacaaacta aacttaacct 188820tcattgtttg
agattaaagg tgtatactaa gggtgtgtct gtgtccatcc aggtagatta 188880aaggtatgtg
atgagactga gccacaccac aactagaaat aggattttcc agtaaataac 188940acaatcgcag
agttcacagt gtgatcagat atcctgcaac acccataccc ccacacacat 189000gatttttgtt
ttaagttgac agatggaaac aacatgggaa caaagccagt gtattttctt 189060ttaagatttt
atttctttat tttatatata tgataagtac actgcagctg tcttcccaca 189120cacctaaaga
gggcatcaga tcccattacg gatggttgcg agccaccatg tagttgctgg 189180gaattgaact
caggacctct ggaagagcag tcagtgctct taacctctga gccatttctc 189240cagcccccaa
agccagtgtc ttttgtaaca gagcatgcaa agatagtctt aaccagcagg 189300tcctccgtgg
gagaattctc tggctagtta gagaaatgca cagggcagaa ggagaagggc 189360aaaagagttg
gagaagggaa aggggctcca gggaggtagg tatgtcgcct taagattgct 189420gcagggaatg
gaaaaggcag ggagagtgcc aggagttcag ggccagccag ggaggctggg 189480gtgtccttgg
ggtagagtcc atcaattaag aagttttcca gcatgggtct cccctccttc 189540acctttcctc
tgtccctcct ctcccttttc caggtgcaca tgaacaaggc aggtgaccca 189600gtcccagcga
gctcagatgg ttcactgcct acttcctaga tttgctcttt cagcctggtg 189660acacagctct
gtgttccgct aaccagagac cagtgcctgc tgggatgctg acatgagtgt 189720tgttcccttg
cttctctaga ctttggcttc agcaacctct tcactccagg gcagctgctg 189780aagacgtggt
gtggcagccc tccctatgcc gccccagagc tcttcgaagg gaaggaatat 189840gatgggccca
aagtggacat atgggtgagt atgtcccgtc ttatcacctg tcccctctgc 189900agatgacagc
tgtcctgtca tgtgggagtg cagagcacgt tcacctgcac ttgcaacccc 189960agtctccccc
agcacccaag tcacatgagc cttggctttc aactactccc tttgcacctg 190020cagaggaccc
ctgtgagggc ctgagcagaa gatggctgtg gcaacaacag agattacctt 190080ttcttgagag
gctgggtctg agaaatgttt ggaatctcac cctaaattca tgtctggaag 190140cagaaatgtt
acctgctctg aagacaattg actttgacac tgacccatat tatatcctaa 190200aaagaggaca
agttggtccc atcatctgca catacactaa tggtctcttt tgtttcctcc 190260aatgctatta
accgtccgta ctctctgttt gggctacaga gccttggagt tgtcctctat 190320gtgctggtgt
gtggcgccct gccgtttgat gggagcacac tgcagaatct gcgggcccgc 190380gtgctgagtg
gcaagttccg catcccgttc tttatgtcca caggtaaggg acccgccagc 190440ataaagccat
gactgcattc acggagaggc aggcatgtgg agtaatttca caagtgcagt 190500gatgctgggt
cagtggccat ttggctgctc tctaagctgc agctgcctca gctcgtccag 190560gaggcaaggt
tccttaggag cgaaataagc cacctgcttt ggcttgggga tcgggctctg 190620ctcagtatca
attcatctga gctgttgtac ctcagtctaa gacggctaag gctttgcacg 190680gcccctggca
tacagattag attaactgct gtgtgagtca ctggtgccat catggtgcta 190740cagtggcatc
agtgcgtgtc acctgtcctc cccacagcct ccactggagt gccagagctc 190800cgcggttggc
actgatgccc aggacaaagc aggctttcgt ctttgtcttc ctatggtctc 190860atttcctagt
tctctagttc tccttcagat tctaactatt taggaaaatt ttttaagtaa 190920gcagacaata
ggataatagc tttttggaaa ttttaacact gaaaacggat accagaaacc 190980cagatgttat
agttagcaga caactcagaa cctctgggtt tggcttcagt ttgggatgtg 191040tttagttggt
tggtttggga tttctttgtc accatttctg tgcatgtctg atccactata 191100gacagtgtta
ccttttgtct agctactttc ctcttaagga gagcatgcac acctttagaa 191160tatgtaggtg
gagtgtgggt tccgtttaac tgagtcagct cagaactgat gacttagaag 191220gtcatgtgtc
aggtgatgat aatgctaagg aaaggggaag aagaaacctt tagaatggtg 191280ggtgggagat
cgttcaaaga ggaacagttg gaaaacgtga catttcaggg acaactggaa 191340acgaaggata
ctggaggatt actgcccgaa ggccccaggg agggagcaat tggggtgtgc 191400ctgaaaggag
ttgagcatgt agactctctg cttttactct gctggaatcg gaagaattag 191460aagctctctt
aaaaatagag aataatatgg ttagacctgt gggggttttc taaattttta 191520ttacgaaaac
tttttaaaaa ttgaaaagat ttttttcatc agcttttaaa gacaatccct 191580gtagttgcta
cactgcttgt tgaaaggaga gtgcagtgca gtgctgtgtg gtgcagtgca 191640gagctatgtg
gagtagtgca gtggcatgta ctatcacgca acacagtgca gtgctgtgtg 191700gtgctgtgtt
ctaaggcaca gcacagtgta gtgcagtgtt gtgttgtgga atgctgggca 191760gtgcagctca
gtgtaatgga gtgttgtgca gtgcagctca gtgaagaagc ctggttggta 191820ggagacttag
agagcatgtt cccagactga ggaatagagt gatttgggac ggatcgctgc 191880tgcacactac
ctggttgatg tgtcagagga attttacaga cattagctcc cttcagtatt 191940atgagctata
tgaggttgtt accccacttt gcaggtggtg ccacatccag gagagtgtaa 192000gcagtgtccc
catgtagaac agcttattag tggctaaact agaatttgag ccaaggcagt 192060atgtctcaaa
taatgtttga tattgcattt aaggtaagaa agaatagtta caggtaaccc 192120cgagatttgt
acctgagcaa cagaaaggat gaatttgcta ctaaatcaag gataactgaa 192180tcgtcaacat
tttggagaga tgtttttaga aatgtcaagt ttgtggtgcc tattagccgt 192240ctaaaagact
gttctggtca gcagttggaa aggagagagt tgtaactgtc aaaactggcc 192300tctttgagtg
tcatagaata tactctaatg ctaccaggaa ggctcgctct ctgtgcctct 192360caggatggtt
agagatgagg aaggtgacaa gggccagaag aatggttagg gaggaaagcc 192420agagtcactt
gaagacaagt gaagctgccc caggaagctg aggtagagga cagagaactg 192480agtgctggat
ttagaggaat ggagctccct ggtggggttt ggtgccactg ccacgggaag 192540ctgatccatg
cacacagtag gaccgagtgc aaggcacagg aaagggggaa gccttgactc 192600ttcccagttt
gactgtacag tgatggagac agagaagtgt gctctggggg gctccaaccc 192660tggtcatcag
atgtcctgcc agtagctgca tttcctgttg tcatggtgac tgcattttac 192720cattccctac
taaggaaaaa aatgaggaca gttttaggtt cactgcagaa ttaaagggac 192780agaagatgtt
catatgcccc ctgcctcact tcccctccca cacacataca cacacacata 192840tgcacacgca
cgcacgcaca cacacacaca cacacacaca cacacacccc ttcattcaga 192900gcctgtcatt
tacaagaggg ttcactgtca gggttgtaaa ttcgctgggc tctgacaagt 192960gtataaaggc
atttatccac catgatcctg tcagacagag agccccacct ctgggatgat 193020cctgtgtgct
ccccccattc ctcccatctt tctctcccca ctggtgatca tcgtctccat 193080acatttttac
ttccgggatg tgatatggtt ggaagtgccg ttttacgttg gccttccact 193140taggaacatg
cacaggcatg caatgtctct tgtgtcttgc tagctcattt ccctttacta 193200ctgagtactc
ccttgcctga atgtactaca gtttatcctt ttgcccactg atgagtgtca 193260tggctgctct
ccagttttga cagtttgtaa ctgagattgc tttgatagcc ttgtgcggat 193320ttgtgtatgg
acacacgttt tcggctcact tgagtaagtg ccacggagca tgcctgtgag 193380gccatatggt
aagagcttgt ttagatttgt agtagactgc caaacggcct tccctagagc 193440tgggctgtgt
tgttgtaaat aagagttctt actgctgccc gacttgcggc ttttgcctga 193500ttagcctgtg
gggcgtggtc ccctttcaca tgtgtgtggt gttcctttca tgtgtagttc 193560tgaagtctgt
gatcctgaac atccttgtat aggtgtctca tcaggtcttc attttttatt 193620cctctccaac
aaaatctcat agtgtttttc caagctgcct ttgaactcct gggcttacac 193680agtcctgcct
cagtctcctg aggatctgga attgctcgtt tatttattag ggtttttcac 193740tgtcttctaa
accccattgt ttcttactgc ttctgagatc cattccttct gtcccctaag 193800tatactctta
gtcatctctg ccagattttt cgttctctct taagccttac atctcctctt 193860acccaaatga
gctgtctgag ccatctcgtt tactgccatg gcttcaccga tcccttttgg 193920ggactgctcc
caattaactg tctccaaatt ctctcctgag gtctagggcc acaaatatcc 193980atccatttgc
tatttagcat ctttaaaaaa attattttcc ttgttttgta gtactgagac 194040tcgaacccag
aaccttgagt atgttaggtg ggcaccctgc ccctgaacta caacctgtta 194100ctcagtgtct
tcctttaaca tcttgaaatc acattcactg aagcattttc caaaatgaac 194160tttattccct
atccacagtt ttgctctatt tggtgtccct ggtgtccccg tctgaggctt 194220ggcagaaaca
agtcttgatt gtttcttctc ttatcaccac cagagccaac tggttagtaa 194280aggctgtgca
gtcagtctgc tattccagta accatgctgt catcttctct tgcctaagtt 194340agactttgtc
aaatctgtgg atgctgagtt ccatccttgt cttctccatg tttctgcgtg 194400accttggcag
acacgaataa taaaaactac acctcacatg caaacctcac aggtacacgc 194460atacaaacgc
acaaatctga tgatatcatt ttatagttta aaaatgtttc agcagtttaa 194520cattgcccta
aagtttactg ctaatgtgtc taaagcactg aaattcaaga atttttacta 194580cagccatgat
aaaaaaacat actttatact ataacttaga acacacacat atatgttttc 194640aaaaatcaaa
atatattgtt ttgagacaga gtctctttct ataacccagg ctgattttaa 194700actaaagaac
catctcgccc agtctcctga gtgctggagt tgctggcagt ctagcctgat 194760cgagtgctaa
gccgatgatc ctgagggtga tggtcaagat tgttctctgg cctacacacg 194820tgcatattca
agaaaaggca aattcagata ttttccgggg tttttatctt tctgaacctt 194880gtcttactac
tatgacattt atcaaaatat actgtaattg gaggctagag tggctcagca 194940gctcagagca
ttgtctgctc ttccagaggt cctgagttca actcccagca accacatgat 195000gggagctgat
gccctcttct gacatgcagg tatatatgca aagtcatgta catgagaata 195060aattggtttt
tcgagacagg gtttctctgt gtagccctgg ctgttctgga actcactttg 195120tagaccaggc
tggcctcaaa ctcagaaatc cacctgcctc tgcctcccga atgctgagac 195180acatatattt
tttaatctta atttatttct tattgtaatt gattctttca ttataagcct 195240tccacaccag
actctgaact taaagaatat gcagagaaag cctccagcct tcccacagtt 195300gtttataatc
tagcagtgtc tggtacagca gcacttccta cacactcttc tgtgtcagag 195360tcaactgcac
cgaccttgtg ttccaggggc tttcattgac tcttaaaatc aggctgctgg 195420tggtgcaggc
ctttaacccc agcctgggag gcaggtagat ctgttcaagg ccagcctggt 195480ctgcatagtg
aattaagacc ttgtctcagc ccggcggtgg tgatgcatgc ctttaatccc 195540agcacttggg
cagaggcagg cagatttctg agttcgaggc cagcctggtc tacagagtga 195600gttccaggac
agccagggct acacagagaa accctgtctc aacccccccc cctcccaaaa 195660aaagaaaaga
ccatgtctcg aaaaagaaaa atgagaaatg tacacaattg tgacttcttc 195720tgtagcacct
cacccccgcc ccctccccca gtcctgtttt ctcttgttct gacctcaggc 195780cctgggcttt
agtcaggata gtgtttgtcc tttctcagac atagcaagca cactctgctg 195840tcccctcagg
tgggcactct gaggcctcta ttgacaccgc cctccccact gccaccaaca 195900gcttccataa
ttgtgtttgt cttaaccctt gtctcagctc cacatgctct aaattgtttt 195960cccacctccc
atgtcatcat tgtcgttgtt gtcgtcatca ttgtcatcat tagctggcag 196020ggatgagcgg
ttttggataa gttttgttca ctgctatatt cccaggccat ggggtagtgt 196080ctggtgtcta
aactcataaa gatgtattaa aggagggaac tcatacacag gtttgttaaa 196140aatacagtct
acgggggtgg gggtgggtac ggcccaccaa agcccttcca caggaaatac 196200tctcactcaa
acaatatcaa gaaattacat tgtgcgtgtc taatctcagc acttgggagg 196260tgaaagcagg
aggctcagga actgaaggtc attagctgct cagtgagttt gagtctagcc 196320tgggccacat
gagatcctgt ttcagtcctt gctccaccct taaatacaca caaaaataac 196380tacatttctc
taaggctaga gtttgtgaag tattttcctg tatttcgtct gctttaaacc 196440ctgcagctgt
gctctggaat tgttactata tactattttc ctgcttgccg tgacgtgtag 196500agaagtgagt
tgccttgtaa aagccacaca gttcacccca gtcagccact cctcggatgc 196560tgtattgttc
tgctcaacct cactgttata aaaaaggggg gggcaggtca ataaaccact 196620tcctctgctt
ttccagtgtc cacagtattt cctgtgagga gtttggatat cctccatctt 196680ccaccccagc
ctctcagacc atgcaaggct cttcaggcct ccccaaagca ggctgctgag 196740catagctcct
ggcaaataac ctagctgctg aaaccacgct cctagtgagt tatcatgagt 196800gctgaaaggc
tctgagaatg gcagcgtgat tgtcccaaat agtgatactg tataatcccg 196860gagaggagat
tccccaagtg aatgaaacaa tgctctgtaa gatgaagcac agaaagcaag 196920aaccagtgga
ggaaaagagc tggcggtcac catcttactg catgctcgtt ctcatcctca 196980gcgatgtgca
tgtgcttagc tttatcctgt accatagacc tgaatcccaa gactcatcag 197040aggctggtac
tatccatatg gtgaggcaca gaggaaaagg aaatcatagg atattccttc 197100aagcatcatg
gagttcagtt tcaagggaag tacacttgag agtctcaccc ggggtcctct 197160ttctgtctct
gggcatagct gtgactcact agacctggaa ttagctcttc ctgtggaggt 197220cgaagctgtc
aggtctgctc tccctctttg tgcttctgtc tctttcctat agagggcagt 197280gtgggtgaaa
aacaagacct gttctctgct gtcaccacct tggcctgagc ttactgattt 197340ctgtgaaaag
atgtagaaac tcagtcaggg ctgagagagc tttccacatt agcctgtgaa 197400acactagaag
atcctttcct ctatctttta tggccaagtc agactccaga gtgtctccag 197460ctgggagatc
agtctctgaa gatggacact gtttctatag taactgtggg atgaagttgt 197520cttctcatag
taggtcaaag cttgttagac acgagtgttc ttccatagct gtcctgagat 197580caactaaggt
cacatattgt tacatggcat ttgtcatggg ctaatgagtg tcatgagtgg 197640gttttaacta
cctagtttat tatggcctaa aacaaccaga tgtgttttac acagctgcat 197700cttctggaac
ctagaggcac ctggcaggaa ttacatgtct tttcagtgac aattttgaat 197760gaaatatgga
aggaatcaca acgttggtct tatggtggtg gataccactc aggagacaaa 197820ggcaagcaga
tcctgtgagg tcaaagctag cctgctctac atagcaagtt ccaggacagc 197880cagggctaca
taatagaaac tctgtctcaa tgtcccaacc tcccacccca ccaaaaaaag 197940gaaagttgag
aaaggactta ctacttaact gtagactctc ctgtcgcttc ggcattgtac 198000tattaaagtg
agaggtagct ccccaccgat ggttggacac actcaggaaa ccaattggct 198060ttataatctc
ttgttattat tttgtagatg actagatcaa gtgacttctg gttagtttgc 198120aaaggtattt
tgagccagtc atcccggcac tcaggaggct gaagcaggag gaacataagt 198180gagttggaca
ccagcattgg ttacatagga ggttggaggc cagacggggt tacataatga 198240gaccatctca
cagcgaaaaa caaaacaaaa caaaacaaac tatttgattt actgtaattt 198300ggctctccta
gtctctgata aatcatgttt gttacaaacc atgtttgttt tgttttgttt 198360ttaaggttta
tttattttta ttatgtataa agtgctctgc ctgtatgtat tcctgcaggc 198420cagaagaggg
caccagatct cattatagat ggctatgttg gaaattgaac tcaggacctc 198480catagccatc
tctccaggcc cagaccagtg tttttgagtg aagcttcttg gattgaccca 198540gagctcagag
ctgtcatcca gggagcattt cagcctttgc cacaagatga taaggggact 198600catttccttg
agctcatata aaatgagacc tggtctagcc agtgtcagca gtggccacat 198660ctgactccac
ccactgatgg aagccagcaa tatacacatt tggttactag attcactccc 198720tgataataca
tttttaaacc cttggatatg tgttttgcct tatcctcttg ttaaatacca 198780cctatgagca
aatatagtcc aaccatttac ttaacggaag gaaaattaat ttaccatgaa 198840gaaactgcac
tgatgctgag tgcattgaga tctcttgtgg gcaatatttt tgagtcctta 198900ttgattagac
ttcattggga cttaattagc tgtaatattg cataagcatt ttatcactgg 198960gaatgcagat
cccacttaca taatgcttct gatggagaat atggcctaca gctactgcca 199020gaaagctttc
acttagagga aggtaactct gccctatccg agtacccatc aagaaccaca 199080cagtgtctcc
ctgggcgaaa gcactttgtg gagaggagca agagtgggaa tgggcgtcac 199140ttgcccgagc
tataagtgca gaggcacgtc tttggaggtc tgctctccat ccagggagaa 199200aaacctgtgg
tgctttggtg tctatccacc tgggaacaca tctcaaacca gagagctggg 199260tgtggtgcca
cacctgtaat cccagcactt ggcaaggcag aggcaagaga atcacaagtc 199320accctcaact
atatgtaagt ttcaagggca acctggggtc tatgagaccc attttaagac 199380aaaacaaagc
tagacctcat ccgagtgaat caggcctcgc cctagtccca tgagtttatc 199440taagtttcta
gaaagccagg gatgaaggtc cttgatagtg ttccagttat aactatacct 199500ttcaagcaaa
ctgttttctg atttatggaa agcctttata gaagaataaa gaaaactcca 199560agtagaagaa
gcttgattcc agaggttggg tgataactaa ctttgggttc ctgtgcacta 199620ggcacagttg
atttaactac ttagttctca gcaggctcta actatcccgt gagatatgct 199680gaatgctggg
ttgtttgatt ggtataaaaa tgaaggcata gcaaggataa gagatgctca 199740cttagaaaat
gctagaacta acctttgaac cttagccctc tgaccccaga gagttcctaa 199800ccattctcag
ttacagttag ttctcgtaaa tagatacctg gtaaggtttt cagagtattt 199860ggagagtcct
ggagaggata tcaaagaaag cattaatagg aggccacgag atggcagtgc 199920aggtaaaggc
acttgccaca aggcctgggg gcttaagttc acttaccaag actgcccctg 199980ccccatgccc
acctacacta gagcttaaat acacattttt aaaacttctt aattaatagc 200040acatacttta
gactctggga gatttctagc tccagccaac ctcttaccaa agctgtcttg 200100gttaaaaacc
aaaacacaat gctattttaa gaatagattt aacttttcat tatctgtata 200160gagatgatga
caaactttat tttctgttta tagagaaaag tggcagagcc aggtttgatg 200220gtgcatgtct
acagccccat cagctggagg gatgagagca aactagtgcc agcctgggct 200280atatagtgag
aagtagtttc aaagactggg aggggaagag actgagagac caagccagga 200340gggaatctga
gaggatatga gaatgtttta tttgcggttt tctttctgga aaaagtagtc 200400agcattactg
agacactgag tcacaaacat ctgaaggcct ggagcgcaaa gcaccagact 200460cctaaagcca
tgtagctctc tgtgcagagg ctcctcacag cccctctcca tctgcgcagc 200520cagctctcct
gttttgatcc ctgacctggt cagagcttgc gagtaacaga agctgacagc 200580agtgtgccag
cttgcatcca attctgacat gcagtttaac tgtttgaagt tctgaaagtt 200640gttcattatc
cacagaaagg gatgttttag agattggact gccggttaat ttttgttccc 200700attttggatt
ttgagattta gaaaaataga gctgtctaaa atttggattg ctataaaagc 200760aatctataac
taaggagtaa acattgatgg gaagcatgct aaaattgtcc aaaatataga 200820ctttggtgct
gaacacttga gaatcccata tgtatttaaa catatgtatt gagcatatgc 200880cttgttgact
ggaaagacta agagaaacta gaccaaacac cttcttgtac acacttagag 200940gaagcatggg
tttctgggta attgtttctt acactcttac aatgccctct ggcaaacaga 201000tggcttctct
ttccaccagc tcaaagaagc tgtgcgcgtg cagggacctg gcacgtcgtt 201060tctttgagac
tgttcttctg cacagacccc ggagcagagc tttatgatgg cactacttga 201120aaggttcagg
gatggcaggc tttccttcat ggggtcagcc cagagatgct ggcatcccag 201180tcccacagag
ctcagttctc cttgtatgat tccttgattt gcaacgcctg tctcatccat 201240cccccacaat
caccagagct caggcttcag taggactgtt cattttagcc cctgacctca 201300ttagcaggtg
aacacgggta cacacacaca cactcctcac acatgcgcgc gcacacacac 201360acacacacac
acacacacac acacacacac acacaccttt ccatgttctc ttgctcccag 201420tctcgcacac
actcgctgtc agcccacctc acagtccttg tcatctcatt agtagttgtg 201480agcatgccct
ctactgcttc gtttggaacc tgcttgtagg tgaatagtgc cgcaacagcc 201540tttggagctc
acacagcacg tcatcagctg gatgcgagaa ttgtttggat ttgtttttct 201600aaagctatgc
tgggtgctac ctcaaacact aaaaatggtc attgtttgtt tgtttgtttg 201660tttgtttgtt
gaggcaaggc ttctgtgtag cncaaactgt cctggaactc actctgtaga 201720ccagactggc
cttgacctca gagatctacc tgcctttgcc ttccgagtgc tgagattaaa 201780agggtgtgcc
accacgtcca gcttctaata atgtattttt aaaggtagtg tttagattaa 201840gaattctcta
ggggggctgg tgaggtagtt cagtggataa aggccctaac tacacaagcc 201900tgctaaccca
agtttgtttc ctggaccact aaccagtcca tcctccctta aaggtggaag 201960agaatgaatt
gaattcacaa agttagcctc tgacctctac acataggcca tgtatgcatg 202020catgtgtgtg
tgcacacaca ataataataa aataaaccac ccccagaaat ccaaatgctt 202080agaagactga
ggcaggagga ccatgagttt aggattaacc tgagtctggc ttatctcaaa 202140aaaacaaaga
aaggacaaca ataaaaataa acagactcta ctgtttagta tctgcctaag 202200tttcttaatg
tctcagtttt aatttcttaa aaaatgtaga ttataatagg tgtcctgtat 202260aggttgaggc
tttacaggac gtagtactct gcctaccaca ccatagccaa ccatgataat 202320atgggcagga
atgtctctgc aggaatcact ctactgacat ttcatttccg tctctctggt 202380tttgacccca
tacagcagca cacctaaatc tttagtaaaa taatggtttt ctggcaactc 202440cagcttgaag
ggtgggaatg actgttctgt tgtgacttct taggtatttc catggtagtc 202500agcctccaag
tgaacaggca gaagccattg ttctccaggt ctgttgcttt tggtttggga 202560acaatattga
gcacgcactt ggccttgatg acctcctgtc tgggccccta ggtactgagg 202620ctctaggaat
acacctccac agctagcctc tgaggacggt gctacagctg tcagcaaggt 202680ttatcagtca
ctgatgcgcc tgccatttgg gaggacctgg ctcatgtttg gacattgatg 202740ctgttctgaa
aggtgcaatt gctgtcttgg aagcttccca ttcttcaaac atgagtctgt 202800gagtctgtga
gtgacagcag gagactacca tgtgacgcat ttctagtgaa aatgagatta 202860ctacatcata
cacagaccat tcctttatca ctgtcacaga gttttgagaa ttgggggtag 202920gtgaccaagg
agttccttat gtccccttgt tatgcagaag agtgatctgt aaaataagta 202980gctgtgaccc
tctgggaagg gtcagtgagg agccactttg ctggggcgtc ctgaagagcc 203040gacaggttcc
ctctgctctg cttccttctc cgtctgctca cttgagtatc ctgtggttgt 203100aggtttgaag
acggtcattg ccttcatttt cacatccttt ccatattttg tgtagaataa 203160cgtgtccaga
gctcgcctga attcaatttt atgagctata tgatactgag aaaacgtggc 203220ttgatgctga
gttcggccat gtttcaccct ctgcagcaga tgaaatgtgt tagcttctga 203280ccgtcggcca
gtttctgctc catgtgacag ctaggatcag tgcttgccct tgtgccaccg 203340acacaaaaca
gagtccctaa tctggggaag ctatgaaaac tctttggctc cttgaacaat 203400caaagattaa
tacaagtttg tgtacataat ttcataattc cttgtgggtt ttttggtttt 203460tgggctttgg
tttttttttt tgtagtgaga ctttcagggt ctcttaggat aaaatctgtt 203520aaggatgact
gagaagaagt ttcagaagcc tggagttgag atttgcactg ggacttatga 203580caggttattt
tgtttgtttg ttgttgttta aagaaattgc ctaggagaag aactctttgt 203640tttaaagcaa
gcctgttaca gacatttttt ggccttggcc ccctaatgtc ttacatgaaa 203700ttttgtgcag
aaagaccaaa ggaaaagagt ggactgccat ctagaggctt gaacaacaat 203760gttacaactt
caaaagctta accggcctct gtgtactcaa ctttgtgaat taagaacaac 203820ttttttcttt
cttcttctct tttcttttct tttcttttct tttcttttct tttcttttct 203880tttcttttct
tttcttttct tttcttttct tttcttttcc tttccttttc cttttccttt 203940tctttccttc
cttccttcct tccttccttc cttccttcct tccttccttc tttctgtctt 204000tctgtctttt
tgtctttctt tctgtgatga cagacatgta tgtcatagat gcttcactgc 204060tgtgtctacc
cttgctactg tagacataat tttagaatgg agatgccatg gtctttgaga 204120taggaactgt
acttgaatat acctttactc acaaagtaaa aacaaatcaa tgtttttatt 204180tagcatctgt
tttggatttt acattaaaaa ttaagagtaa ttcttttaaa tgactctgag 204240tgtatatttc
atgataatga tgctactata agtggtgtag aaattgcaga gttgaatttg 204300ttctggaaaa
aaatagatga ctagaatgta tatccgcctg atgatgcatt ataggacagt 204360caatagcata
tccttatggt agctgaatgt tttaacattt caaagtcttg tttgttcatt 204420tataaatgtg
catctttata gtacctgatc taggattgtt atgaagacta agtgaaataa 204480aaagcatctt
cacgatacag tcttacttgg ttaagatgaa tattcaataa atattcatac 204540attcagttcc
cattagatat aatgatcatt tttggtattg gatattccat attgcagtaa 204600aaaggacaca
tgccttgcat tgtcgcagag attgtgtcag caagcacaaa tacgaacaag 204660agaagtcctt
aaataattca tgtaaagaaa agtcacgtga cacagtgaag cgtaaccgag 204720cctgttttca
tgtcagaggt cagagatgag tttctgagga agtgacagtt aaactctttt 204780tttttttttt
tttttttttt tttttttttt ccatttttta ttaggtattt acctcattta 204840catttccaat
gctataccaa aagtccccct tacccaccca cccccagaca gttaaactct 204900tacccgcatg
acaggcagcc ctccatgaga aggcctgtgg agtttccatt tcaactagag 204960gactaagcat
ggaggccaga cagctaagag aacttcactg tgggaaatca gacaggaact 205020ttttaggccc
aggacttaac attttcattt tgagggtcat gagaagaaac tgtagagtta 205080ttaaagtggt
gatgttagcc ttagccttag aaaaatgcca gtggagacta agacagacag 205140aggcaggaag
cccgcttggg aaccttttct ggctgtctca gccagcagcg acggcttggg 205200atggaccctt
tggctctgta ggattgtggt taacggcacc aggtcagggg ttaggggtaa 205260attcttgggg
taaactgctt acattgctgt gtttggatcc ctagcaccca tgcaaaagta 205320gacatggtgg
tacacacccg aaatcccaac actgagggtc aggatgcgaa gatctcgggt 205380tcaccagcca
gctcatatag tggagcttca ggcttatgtg agtcactgtc tcaaaaagta 205440tatagtggaa
acaattaagg aagccatcgt agcgttacct ctgacctcca tccttgttca 205500catagacaaa
tgaccctgac acacatgcac acacccatcc ttgttcacat agacaaatgg 205560tcctgacaca
cacgcacaca cccaggtaga catccagact attggtttgg atctgactgt 205620ggcctctggg
ctgaacctgg gccatttcta aagtgggaag gatgttcaca aactgctctt 205680aggtttgtgg
tggggctgag gtagcagttg taaagcgctg tgaatacgtg cgcaacgcgg 205740cctcatcact
gtctgccgcc ttccctatga ctgttgctcc agcatggtca tcagagctcc 205800cagtttacac
atgagagctt ttgtaaagtg ggtggctttg aaatcagaat ataggcttct 205860gttttggaac
tctctctcca ggataacctg gagtgtgagt tgaaggcaga agagaaacag 205920aactaaaaca
gggagccgag actctaccta ctgctcttac atctagccct atcagctcta 205980ccagcccccc
agacccccca ctagactgag gacagctgtt tgtctgttgc agagtgtgag 206040cacttgatcc
gccacatgct ggtgttagat ccaaataagc gcctctcaat ggaacagatc 206100tgcaggcaca
agtggatgaa gctcggagat gcagacccca actttgacag ggtaagccgg 206160acccttgcct
cagggaactc ctgattaact ccttctcttc ttcagtggtt gtgatctgcc 206220taggacctaa
agagatgagc agtaggaacc agctgctggc taagaccagt ggcaggtgaa 206280ttcacaggga
gccgcgggat ccagcaaggc tgtggagaca gtgatactgg gcattaccac 206340agaaatcata
gtttgctttt gacttctgag acagcatact cccagttctg caggtcactg 206400ccaccagagt
gcctttcttg tcttgagtgc gctcccttca acagcttctg tcacatactg 206460ctgcacccca
ttatgatcac tctcgtaccc caggagctca ggaagcagcc ctgagggttt 206520tgtcagccca
tagctgattg ccagaactgt cttgcttaga cttcgtatga cacccacaga 206580atctgcagca
gtggggcata gaacagcttt gtcaatgtgt atcccatgcc gtgttgatgt 206640agttaactgg
ggtctgacgg cttgcctcta taactgtatt atattacagt taatagcgga 206700gtgccagcaa
ctgaaggagg aaaggcagtc ggaccccctc aacgatgatg tcctcttggc 206760tatggaagac
atggggctgg acaaggagcg cacacttcag gtacctaaga aggagtgcag 206820agcagtgaga
taagcggccc ttcctcttgc ctgcctttcc tgcagtgtcc ccttcctgag 206880ctcgtgggtg
ttcctgcttt cctccctttc cctcttcctt tgcccttcct ggacctgaga 206940gggaaggaag
gagctgcttt gtgctgtgcc ggttgtgtct ggtgtgtcag tgaggcgcca 207000cctccgagtc
tcactctccc tttctctatt ggtagtcatt aaggtcagat gcctatgacc 207060actatagtgc
aatctacagc ctgctgtgcg atcgacacaa gaaacataaa actctgcgtc 207120ccggagcact
tcccagcatg ccccaagcca tgactttcca ggcaccagtc aatctccagg 207180tgggcaatgt
ctctgagacc taggtgagaa gaggttatac cagggcaagg gctagctact 207240gctcatcagc
ttttggtcag gagagattca tattcatcca tctatctgta tctcctccct 207300tgtcagaaga
ccatcaaagt ctgggtcttt ctttgagaga aagtcgcatg gcagaaacag 207360ttgtcttctt
cgttttgttt aaagaagtag caaatcattg tgagatacca ttctccctaa 207420agaatgcttc
cttgctgtgt tgcctgagag cagaagaacc aggctttggc aatcaagact 207480gctttgaata
taatcctagc cattgggaat ctgaggcaga ggaatgagtt caaggctagc 207540ctgggttaca
tagcaagagc atgtcttaga ggaagaggtg agggaagaaa ctactttgaa 207600aagctgtcat
tatttcttct agtgtctcag gtctctgtgt gtctgtatgt gctgctttct 207660aggcggagca
gacaggcact gctatgaacc ttagcgtccc tcaagttcag ctgatcaacc 207720cagagaacca
aattatagag gcaagtagcc acatctgatc actgtcaact gaaaccacgt 207780ctcttcccat
agctacaatt cctttccttc cttctgagtt acttctgatc aactgtgttt 207840ccctccacct
tagcctgacg gggctgtgaa cttggacagt gatgagggtg aagagccttc 207900tccagaagcc
ttggttcgct atttgtcaat gaggaggcac acggtgggag tggctgaccc 207960acggtaagta
cctggtcagc atcctgctca gccctaagtc aaaaggttcc gccagggtga 208020gtgcctcttg
tggcacgttt tctgagaggc cacactaggc catggccaat ctgactagtt 208080attctcccta
tatgcagtgc ctcttagcag ccatgtgagg agagtgtaat aacatctttg 208140ttgatagatg
gagttcttct agtctaagtc atcagaaata ttctgtagta ttcagtcacc 208200tttagaaaag
tgtagtagtg caagcctttc atcccagcac ttaggaggca gaggcaggag 208260gagctcttga
gttcaaggcc agcatgatct gtatattgag ttcaaggaca tatagagaaa 208320ctctgtctca
aaaaataagt aaataaatct gccaacttta gcagctttta gagatgctat 208380ctacctcgtg
ttctatattg gaactcttct agaaagagga gacaaggtgg tgtggcatca 208440tttatatatg
tggacagtta gaggcacttg cctgacacaa gcaagaatca ggattcagta 208500tcctgctttg
tctcaaaatg aacaggaatc ccaaaacata tttcccaaag tgttccttga 208560ggtcctcgtg
ttggggaagt ggattcagga ccagctcact ccatttctac tctgcagtcg 208620agacctgtca
gcatgagcga cagcccatct tgttggtgaa tgttttcctc actgagcagg 208680aaagagaggg
ttatatatag ctagccttgt cctgagagtt cagctcaggg cggagctggc 208740tttcttatgt
ctgtcttctg agtggatccc cagaagaaac gcccatgcct gctcgtttgc 208800ttgttttccg
tgcttgttct cgatgtgatg aaacaagcaa gtgagagaac atttgggttc 208860cacacagaat
gtgtcactgc caacgagggg tggagtcctg agtcgtgatt agtggaaaaa 208920tctcttattt
aaagtctgct gggcatgaca gtcccgaaca tccagttctt atctgtcctg 208980tcagcatgga
cggtagtaac cgaattcttt ccctggtgaa tcagttgcta cttcaggcag 209040tcattgtctt
agcggatgcc ctgtgctctc tagaaacttg ctgttcccct ccaagctttg 209100agagcctggg
ctagagttgt gccagcctgt gtgtctccta ttggctttcg aaagggatca 209160atgaagtaga
ctccccaata actcagagtg aaattccaca taggagacag actccacttt 209220gctttagtgt
cttagacaga aatagaaatt taggaggagt aacgtccgga aggtggtgct 209280tctgccggca
tagagacctc agttcagatc ctcagtgttc atagagagcc agctgtggca 209340gcctctgttg
taactacagc tctgtagagt ggagacaggc agatgcacca agctcacaga 209400cagcctgaca
acaagcgaga ccgtgagaga cccgggagag catgggagag gaaggcttcc 209460tacctctggc
ctccatactc atgcatagac atatgttggg gcactcacat gcatttacta 209520tcgtacacac
atagactaca tctgcacaca catgtataca catatgaaaa aaatagaaaa 209580agtcagacag
tggcacacac ctttaattcc agtactcaat agacagaggc aggtgggtct 209640ctgagttgga
agccagtctg gtctatagag caagtaacat gacagccaag gaaggataca 209700aagggaaacc
ctaacccaaa agaccctcct acccacctcc aaaaaagatt tgtgtgtctg 209760tatgtgtgtg
tgtgtgtgta aaattttttt actgtactag ttgtagcggt agtattgact 209820actgtactag
ttgtggtggt agtattgact actgttctag ttgtggtggt agtattgact 209880actgttctag
ttgtggtggt agtattgact actgtactag ttgtggtagt attgactact 209940gtactagttg
tggtagcatt gactcagact taagcattct gagtaaccac acttctctct 210000tcctgtttcc
cgttagcacg gaagttatgg aagatctgca gaagctgctg cctggctttc 210060ctggagtaaa
cccacagggt ccattcctac aagtggcccc taacatgaac ttcacgcaca 210120acctgttgcc
catgcagagt ctgcagccaa ctgggcagct tgagtacaag gtaggaggcc 210180atggaaagga
cctgcccaca agaaacaaac ttgatcttcc cttggtaggc tctgacagtt 210240ctgttccagt
actggagagt ttcctgaggg aggggagttc ccttctgtaa actgctgtgg 210300tgatgggcga
tatctccagc ccccctcacc ccagcagatc ctctcactgt agtagatgag 210360ggtgggctgt
ttactccgtg ttttcccatc tcaccactgt atctgcctac tctcctggca 210420ggaacagtct
ctgttacagc cgcctacact acagctactg aacggaatgg ggccccttgg 210480ccggagagcc
tcagatggag gcgccaacat ccaactgcat gcccagcagc tgctcaagcg 210540cccacgggga
ccgtccccac ttgtcaccat gacaccagtg agtagcagcc cagcctggct 210600ttctcaaagg
tttttgataa gaagtctgta ataaaggggc tggacttggc tgaaataccc 210660acagtcctct
ctaatacagc atcctgtgtt ttctctgacc tgcctcctct tccacagaga 210720cacctcggag
gactttcccc agcagatgca gttcacacgg gcagtgctct ctagaatgaa 210780ctgcttttta
attttcatct tataaagaca agctggcagg gggtgcacac gtgcttcagt 210840gcattcgtgg
ggcttaaagg acagctttag ggggtcagtt ctccccttcc cccttcatgt 210900gggtagttcc
tcaggcttgc aaagcaagct cttaccgctg agcacctcac cagctctcct 210960gtcgtcagca
ccacctgaca tttctggctc agcctcgggt gatcgtgtga ttacattgtg 211020gctctaactt
cagtcggtgt ctcagtcaca ccattttgta taatggtgat atgcaaaggt 211080ttaatctcac
agattggttt ctgtttattt ctggtgtgtt tctgtcatgg tcctgtcaga 211140ctgaatagta
tctccacagc ccttctgagc tatttggggg agtattgctt gaaatcacat 211200tacttggtga
cttctgttca ccgatccatc gtggatcaat acgttttaaa acactcggtt 211260aacagaagct
cactctggct ctctctgctt tacttctcct gggtttggtc acagagcggt 211320gtgtgagccc
atgagtcacg ttgtcagttg cactgcagtt cagaaaacag ttgcaccaga 211380tctggtggtg
tgctggttat gatatcaaag ccgagttccc ctgtatggag aaaagcttat 211440ggagccgtgt
agtcccagcc cctacaagtc aggccaggag ggtcagtgca gccttgcagc 211500taacctggtc
tacattgtaa gtcccagtct aaccacagct acaaggcaag acacagcctt 211560aaaaaaccag
catgccagat tgaatgccaa agtgaatgac atggctgatg ggtggcagag 211620gctcttcatg
ggcaaggttg gcattggttg gcaaggatca gcatcagcat tgtggatagt 211680ggggtgactt
cctctgtcca ctggactcgt tgctgccaag gtcactaaca agctcttgtt 211740gataaatcca
gtaggcattt ttaatcttta tctttttgga tggctcaact ctattagtca 211800ttgttgacct
tcccctcctg ccccccttct ccgtagtact ttgtttttgt tttttgtttg 211860tttgtttttg
tttttgtttt ttggcttctg tagttatcct aggttttcct tcggccagtc 211920agtcccctct
gaggtttctg ctcaggattg acttagccac caaggcccgt ccccttcctt 211980ctctggatga
gcctgtccac ttcccgtcag ctgccatctg gccttgcacc caggatgctc 212040ttctgagctc
tacacatctg catgtgtgat cacctctacc ataggtttaa tagctacctc 212100acaagtgctc
acagtgtgaa tgcagcatgt ggcacttgtc tttctttctt ttctctccca 212160gggataggga
cagcactgtt tgttttggtt ttttatcttt atacaatttt tgttattccc 212220tctgtcagtc
agttgtctga tgtttgtgaa taaacagatt tcatctctcc atctctgccc 212280ccttccgtca
gccgtggtca ccagtcacct tgattaacac agtgactccc agcaggcacc 212340tggcttgact
cctggttacc actggcttcc ccttgcaccc tgcaagtaaa gagaccccac 212400tttcccaaac
acagatcctg taacaccatg cttctgctta aaatcctaca gggattcacc 212460actgcccatc
ccaaaatcag tctgtgtgct cttcaaggcc gttgataaca gcgtcttccc 212520atgcctcagc
catagctact tcttgtccaa ctgtttacta cagccttaga gctaaagtag 212580aggatgtgaa
aaatttcaga agttggaatt atttcaataa ggttttgttt gtttttgttt 212640tgtattagcc
agttttaaag ataatattta tttttatttt tggttaatct ttttttttct 212700tcagtttttc
gagacagagt ttctctgtat agctgtcctg gaactcactc tgtagaccag 212760gctggtcttg
aactcagaaa tctgcctgcc tctgcctccc gggtgctggg attaaaggcg 212820tgcgccacca
cacccggctg tttattttta tttttaatta atgagagaag tgtaccagag 212880ggcaggtgct
ggcagaggtc aaaggtgcgg ggtcctttgg agtttggttt acaagttgtt 212940gtgaaccacc
cagcatgagc aaggggtcaa actctggacc tctgcaaggt cagtgtgtgc 213000tcttagccct
gagccatctc tccagccctg gaatccagtg ctttagacct gttggccatc 213060aagtatggtt
tctaaatagc acctgaggca tgggtgatgc ttatctgggc cactgggcca 213120agaatatttt
ctgagggtgc acaacatttc tatcttcacc cagggaagag ccaggaacct 213180cagtgtggta
cttctcattg cgtttatgtc tcagagtata gtgagtattt aaaaacatgg 213240aattacaact
atttgattat atgttatgca ccaatcacca tgatgctttc ccggagttca 213300gacatccaga
ctctggagct gacattaatg tgaggccacg gtcagttcct aggcactcta 213360ggtaggcagt
tcgatgcatt ccaggtcctt ggacactgta ggccttccct cttctctcag 213420cacatgaccc
tttgctctct gctggatgtt cactcctgtg cacacctcgg gtcacaggcc 213480agctgctgct
tcctccaaag tgccttcttt ccttcccaag ctcccatgga ggacctgaga 213540gctcagtcgt
gcacttacga ttgtctgctc gtttttctct aaacaaaggc aaagaccaca 213600gctatgaatg
cgcagctggt cctaaaggag gcctcgagta ttagatgaac aagcacatgc 213660ctgtgaacaa
gggaagaaat ccagatatag cacctgagcc cgatggagct ggaaagcaag 213720atggaagaaa
gtcctctcta gccaccgttc tagggaagcc tttgaaataa gaacattaac 213780aagacccttg
gcctcagtcc agttaccaga gttgagggca tcacagaata agctgtcacc 213840ctgagccttt
ccttcctgtc tctctgcagg cagtgccagc agttacccct gtggatgagg 213900agagctcgga
tggggagcca gatcaggaag ctgtgcagag gtaatgtggc acctggcagt 213960gcttgcagaa
cgtccttggg caggctcccc tgcaaccagc gaaaggtcac ctctgcccag 214020ggaggtggtg
cagtgcagct tcaacacttg tgtggtctct ttgctcaagc cagatggcat 214080gttcctcccc
acacggaagt aacagaagac tgcccagaaa atttcatttc tataagcgcc 214140attggaagcc
ccttaagtga cagcaatacc cttaagaacg ctttctctcc tccctccctc 214200ttccttgtcc
ccgcgttcat attgcaactt tggtagtgtt caggcctaac gcctgctcct 214260ccctgccacg
aactgtttac tgaaaaggag ttggagattg gagatgacag tgatcctagc 214320tagtctggcc
atggacctct ggcatggact catccgtccc aggagaatga atgaatgaat 214380atctcctgca
ctgtttgctg tgtgtttcct ccactccctt gtaccaacac tgagatattg 214440ggaagaaaaa
acaaacatgg gggttggggg gaggggcagg gacagttgta aatatccatt 214500gtttgcagaa
ccttgttgag agatgcctga ttcacagagc gacagtgacc atcaggtgtg 214560ctgtgcagtc
cgatggcctc agttccagta gccatggtct gcagctccat gcatgccccc 214620ttgtggagtt
gtctttctta ttttctgtga aggggttttc accagaatcc agcatgtatt 214680ttcccagaaa
tacaggtgtt cttcaagatt atatgttttc ccttgaggga agttgaaata 214740aaatggtttt
catgggctct cggggaaact gtgggtgttt ttatcaatgg acattaacca 214800cagatggctt
ctttaagcaa gtttgcatac tacaaattac agtctgatga cagcttttaa 214860ctgacgtagg
caatgtagtc aggaatgaac taagagcctt atggttgttg ttcaggaatt 214920gttcttcacc
cagaaggtct ataggaaaga ccaaagaagg tgcccttgtg cagaaagaaa 214980gccctagtga
tcaggggtaa tgctggccta gtcaacataa ggaaaacaaa aaacacaaaa 215040acaaaaacct
ggtgactttg cctcagtctg atactcttgc ttctatggtt tgctgataaa 215100aatgaatttg
caaatgcgtc ctactggtgt cttgaagaaa cgagaaagta gggaatgttc 215160tggatccccc
tccacccctt ggaaaggtgc agctgggttt taccttcttg ccttagagtt 215220cacgtcctct
gcccccacct tcttcagacc aacattggaa ggccagtgag cctgtcagtt 215280ggaagggaca
gaaaggagtc ctgcttctct tatctgtatt caagacaagt gaagtgctgc 215340agggggcctg
gagcaaacgc aggcccccgg gtcttgttat ggtgctgacc tgtgtaggtt 215400cgcaagctcc
gtagagtgaa tggcttcatg gagaccttgg cctcctcttc tgtttccttt 215460cctttcttct
ttacctcctg aaaatagatc tgaacatcct gtgtggtttt atttcttcat 215520cctctaagtc
tgggagccac atcagttttt cttctccagt gattgagttt tggtcacagg 215580acataaggga
agaactcagt tgtcctcaaa caagagtctg ttttctttgg catgtagtaa 215640ggacaccaca
ggcctctgac ttcaggggac gtaaattgat tctttctgaa tacctcactt 215700gtccctttaa
taggccttag gttctatttc ttctaactta tagtttagaa atttggaaaa 215760aaattaatat
gtaggagaga taacttcttc tattgaatgg aataaaggaa attggttcca 215820ccgcctttgc
aagctagatc tccctttctt ctcttaatgg cgactcgcaa gctcgaaagc 215880agccacctca
gtggtgagcc aactgttggc cggttaggca agcttcacct ccatcctgtt 215940gggggttgct
tactgtggag cccttttggc accccatact gtcctaccca gtgcttcaga 216000ctaacttctg
ttgcttcttg cgcgggaaca ttcttgtctt tttttactat gaaatgtcct 216060ccctgcttgt
tgcaggtact tggcaaatag gtccaaaagg cacacactgg ccatgaccag 216120cccgacagct
gagatcccac cggacctgca acggcagcta ggacaacagt ctttccgttc 216180ccgggtctgg
cctcctcacc tggtacctga ccagcatcgg tgagtagccg cttggcagtg 216240tgagcatccc
ggaggctcat tggatcagca cccttctgac tagcctccag cttagagtga 216300ctagctctgc
ctagcagcca cctgccatcc cgagctcaca cctccgctcc tagccctaac 216360caatgcacag
ggcaaaagct ttctcttgga ttctggagca gccaaggctc ttccatctca 216420tttcttagac
cacctactca tcacctgcat ctgctgcatg taggcctttg agagagtggt 216480actctcagaa
ggcagctcta gaagtaagga ctttgtagca acatccccaa acatgaccgc 216540caatagttca
tcgccttcag aaaatgggca cttgatgtgg cattagagca gcaggctggc 216600tgtagacaga
ggcataccct tgttgtgtgg tagaacagga gtgttgcatc cttttgagtg 216660ctgtgtttgg
gaagtaattc tttgagtatt ctgacagcaa gatcttttgc taggcctctg 216720ttatttagaa
ttcattacct tgaagagaga aaccaagttt ccctctaact ctaactagat 216780aaatttgctg
attccaaggt agcctgccag caagagagct gattgtcctc catgactcct 216840tgatgactgg
cagtcttagc catgtccatt ctgatgctgt cccctagctc ccaggtcatg 216900tttcccaagt
cgtcagccat tgcttgatct tgtttcttcc agtcttcttg gggtagggtg 216960ggatagtgga
atgcagcctc ctccagaagg cgaaagcaga tgggttctga ggaaattcag 217020tacacatgtg
tgccaatcgg agggaacact tgcaactagc cactcagatc agctccatac 217080agggttctca
ttgtgcttct tgtgagcagc aggtaatcag ctgaggcagg tgaactctga 217140gcagacaggg
acataattag tgccacgctg gaactctgga agaaggaaga taagctttca 217200taattgaccg
tgaacaattt agaaagaaaa agtcctatta ggaactaaaa gaaacggtga 217260aggttctcat
gcaagattgc gatggtgcag cccccgtgac ggaaacccct gggttgctgc 217320agtcagtcac
ctcagagagc gcctctgtgc tggctggctg gcgagctgcc cccaccccaa 217380ggcagctcgc
atcgtgcact ggtcctgaag gtgctttcgt tgcttctcac ctcttcctcg 217440tctgatattt
gacttgtcag ccctccccca gggccttttg tttacctttt gtccattgaa 217500tacctggctg
tacttctccg tgctccttgg gaaaatggtg atgagcactg tccagccagc 217560cttcctcaca
gacgctctat tctaccaaca tttgttaaaa gaagaccaca gcagcctgcg 217620gacagggtcc
atccgtggga catgcattgc gcctgcagat attgccaggg ccttgctgcc 217680tagagccctg
ctgcctgttc ccatctgcac atgtgttacc tgggtttcta gggccaaggc 217740agtttgagtt
ggaaacaaat gaatgcttga gtgagaaatc atgtactgtg gggcggtggg 217800gtcactatac
aacgcacaag agattaatgc taattcagaa gaaaagagaa gtgttctaag 217860gccgtaaaac
acacgatgtg acgcaggcag cctgtctgcg tcaccggatt cctttcgttt 217920tctggagcat
gattaaaaga acagaatata tatctattct ttgtgttata ataggtgaag 217980tccaccatgg
agaccgaaga ggggctggtc aacatttaca cccctggaag tgtatgcttt 218040aaaagttggc
acaaaacagg ttctatccag ttgggggcta catcactgtt ggaagagtat 218100aggggagata
gcagcctatg caaggctgcc ctgggtgacc gtggttgctg ttgaaaacaa 218160agttgtacac
gcttgacact gcccatggct ctgcagtggt caggtccctc ggaaccaatc 218220ccctgaagtg
actgagccag gctgagctgg ggccgacttc acagcctgag agtccggaaa 218280acggtgccac
accttgaacc tgggatattc ttgctataat gagaaagaaa tggtttcatg 218340cagaaagaca
gctcgaagaa catccctggg tgacggaaac ctgtctattg cctgaaaata 218400ctgaaagtgt
aggcgtccga tgtgagggga gataataccg gtgctgggtt tccattcaga 218460ggctgaagtg
cagagagaac aggtgtctgc aagcatcctt ggtgaactca gtgtctggac 218520cgtgacatcc
tttccccagc cctgattaat ctgccttgta tgttactaaa acaagtagga 218580ctccatgggc
atttcactag ctcaccactg cttgaagctt tgatgacgtc tgagtaaggg 218640ctttcacccc
gacatcagca ctctcttggc ctcgctgcct ggtcctcatt tctcctcagc 218700ccttccctgt
ctgcactgta tttgaacttg cttgttcgcc tgcttccttg gttttggctc 218760tgcttcagtc
caaactggca aggttcccca ccccctcacc attggctcag cgtgatgtca 218820tctctgcctt
agacctgcta ccctgaccct ttccatcagc tgtggggacg ctcgctgcct 218880ctgcagtctt
taacctgctt atctcagctc ataaacatct ctttctggct aggcagcaag 218940tgtaggtgtt
agccagcccg gtgctatctt agggctcctg atcaacggtt cttctttctc 219000cccataagac
atggctgtgt tctgactgaa cactggggac ccctctgtca gcaggaagtt 219060gggcaggtgc
tgctgtgtga ggagatagca ttcacagtag gaaggaggcc tcatgtgtgt 219120tcataaggta
cgtgcaggat cttgaggccc acccacattc ctgaggaata cgctgtctcc 219180gtgctgggat
cagaggtccc tgtcttcccc caccccagcc tccaccctcc cttctctaga 219240acagaactgt
gagttccagg ccagaccttt gaccacagaa ctgactttgg tttcatccta 219300gccacacata
gattactgct agaggtaact cagggtcaaa cggtgaattc taagtttcta 219360aagataccag
gcagggatct ggttttaaaa accatagctt gcacaacatt atccacacac 219420cgccccccaa
atgcaactac aatagaaaat aaatgagtga ctataagaac caagcctgtg 219480tggttcagcc
agtcctggcc gtactgcgga gttgcaccct gctctagtat gtttatataa 219540gaaccggatg
tagttgaccc caggacctca gcaggcctgg gaagtaggac caacctgagg 219600taagtggagg
tgggagatga gggcctgtag tccactcagg gggacagcca cctcaggaag 219660tgacacggag
taccatgtgc agggctcctc atgcatccac tgtctctgta ttcatgtaga 219720cccatggtcc
cgtgtgattg gtcataaccc cccgagtcct ggctgctaac cgtctcttcc 219780catatattca
gctccaccta caaggactcc aacaccctgc atctccctac ggagcgtttc 219840tcccccgtgc
gccggttctc agacggggct gcaagcatcc aggccttcaa agctcacctg 219900gaaaaaatgg
gcaacagcag cagcatcaag cagttgcagc aggtaatctc tggaggggca 219960gggggagcag
tacagtgcca ggacccgggc agtaactctc catacccttc atgtcaacca 220020cactgaggtg
ttctagctta aagcagaata gctttcttca atatctactg ccctccctag 220080ggtcaaacct
gcttccctca taatgagact aaaaattttt tcccaccatc tggaattcat 220140tgggaaggca
tttctggttt gatttttttc ttgggaacgg tacttgtaag caatcttggc 220200aggccccttg
tatgcagggc acggggtcgt agtggacccc attgctgtac tttctcaccc 220260ccggcataat
ccccagctgg tattgctccc agaggtagca aacctgctcc caggatactg 220320tgacgagcca
agggcttcaa gtagcacgtg ctctctctgg gtttatagtt gattccacac 220380tgggcattcc
acagtgtgtc cttggcgttt cccactgctc cccagagagc agggcgtgag 220440gatcactgtg
tgcatgccca acaaggatac cgttcttcca tggctcattc cgcccatgag 220500accttggggg
cagatctgcc tctcctgagg tcatggcatg gggtagactt ggccgtgtcc 220560cgtttgtccc
cactgctttc ccttcaggag tgtgagcagc tgcagaagat gtacgggggg 220620caggtggatg
agaggaccct ggagaagacc cagcagcagc atatgttgta ccagcaggag 220680cagcaccatc
agatcctcca gcagcaaatc caagtaggcc ctcactccct cttcgctctc 220740tcagaatgcg
tttttgagtt tgctggcagg cacattggcc tgtgcattgt ctgaaagact 220800cagggcagcg
tggagtgtga gccacgtttg tgggtgacat gtctgagtca cagcgctttc 220860tgccccttcc
caggaatagc cctaatgcct ttcgtagctc acgatgctgc cgttcccccc 220920ttttgtgttt
taggattcta tttgtcctcc tcagccctcc ccacctcttc aggttgcctg 220980tgaaaaccaa
ccagccctcc tcacccacca gctccagagg taatgaacta cttagcctct 221040tcctgcattg
ttggctggct ggacggtgtg gctcccttgt ctgacgcatg gggacgcttg 221100actgacttga
gcatttggga tagtcttcta gaagaacagg gaagccgagt tagagtttga 221160agggcttact
agaatgctga ctatttcctg agctccatga acacagtggc ctgacatcca 221220tcgaaggcca
ggccagtgag tgctgagttg gtggcaggga aggactggta gactgaggtg 221280tgggcaagct
gtggtggcct gctaccgcag ttgtccgccc caaactacaa actgtctgtc 221340tgcatggatt
gtctggctga atgttaactg cagatggttc tgtcagctca ggaggcttat 221400gtacctgttc
tgtccttttc taaggttaag gattcaacct tcaagcccac cccccaacca 221460tcccagcaac
catctcttca gacagccaag taacagtcct cccccggtca gcagtgccat 221520gatcacgtct
cacggtgagt agaggccgag ggagtggata catattgtgc cgtgcaggga 221580aagcctggct
tttaggcttg gatttgttgc tggtggtggt ggtggtggtg gtggtggtgg 221640tggtggtggt
ggtggtgtgg tggggtgtgt gttaaacttt gtttcttgac tgtgaaacct 221700tgggtaataa
gtacttggct ttctcaacaa taactgtaat aatagcaaca cttaagaaat 221760atatataaat
cacctgggac agtacccaat ataatagtcc ttaatacagg ttagccacta 221820ttgatgtagc
tattaaaacc tctccagtcc tcgtactagg tgtgaagact atgggtgcag 221880atcctcagac
ccagcacaca gtcaggtcct tgccagtctc cttggcattg tggagaaaca 221940tagaattgct
cttcctcctc caggtgacct tgagtcagag ttggctcttg ggttctgtcc 222000cagaaccacc
gcacgagaat gtgcagctta accaactctc aggatcattc ctgcatatcc 222060ttggttaaga
aacactgcat acaaactccg ctaccctaaa tccagccata gagcagctct 222120tgggggactt
aattggaaat aaaattgcag gggagcccac ctgaccgact gagtcctagt 222180tctgtgggta
ggacccagtg agttagatct gtttctgcca gtttctggtc ttgtcttgta 222240tagtgaggtt
gaagaaggct gttctagatg ctacctgctg tggggtctcc tctagctggc 222300aggtaacctg
ggcacttggt caccctgtgg tccctttctc tgcaggtgct acgtctccct 222360cccagtttca
aggcttaccc tcccatggtg caatcttcca gcagcaaccc gagaactgtt 222420ccccgcctcc
cagtgtagca ctaacctgcc tgggcctaca gcaggctagc cagtcacagc 222480cagtgactat
ccagctacag gagccagttg acatgctcag caacatggcc ggaaccgcgg 222540caggctctgc
agggcggagc atccccatca gccccagcgc cagtcagatt cagatacagc 222600accgagccag
cctaatggct cccttcagct atgggcaccg gcccttgtcc aagcagctga 222660gcgctgacag
tgcagaggcc cacaggtgag tgagaaggga caagtctgct tgtgctctca 222720tgtcacccat
ggtcaaagcg gcatggtggg cttgttgatg agacaggttg ttagtgagag 222780aagaggaaat
ggcagagggc cttcctgatg gcctgaagga aggaagatct gttagaggaa 222840catgtctgtt
cccctgactt attattctag ggttcttcct tctctgttgt ctctaagaga 222900ctattattct
aaacagctca gattattatt atttttgttg ttgttgtttt gttttgtttc 222960gttttgtttt
gagacagggt ttctctgtgt agccctagct gtcctggaac tcactctata 223020gtagaccagg
ctggcctcaa actcagaaat ccacctacca ctgcctggct cagattattt 223080tttaagaaca
gctagattag actgtgtgta tagctctggg ggtaggaggg caagcctgaa 223140tccctggttt
cagtccctgc caccagagaa gctaggtgtg gtagcacatg cctagaaccc 223200cagcgttcta
gaggcagagg caggagtggc aggagttaga ggtcctcttc agcaacatag 223260cgagtacggc
tagcctgggc tgcatggaga ccctattcaa gaaactatcc aaggtcagaa 223320tgttgctttc
aggataatta catgcccagt gccttatggc tcttcaaaaa cttggatgag 223380cagataaggg
gatgaatagt ggtggtgtgc acagtcctcc ctgccacagc acaggtctgt 223440accatgagag
cttcgtgcta aggaaggcga gtgactgtcc ccagggaagc tggtgtagtt 223500actggaatgc
ctggtactca taccattttg tgtctgcagc ttgaacatga atcggttctc 223560ccctgccaac
tacgaccagg cgcatttaca cccccatctg ttttcggacc agtcccgagg 223620ttcccccagc
agctacagcc cttcaacagg agtggggttt cctccaactc aagccctgaa 223680agttcctccg
cttgaccagt tccccacttt ccctcccagt gcccagcagc agccacccca 223740ctataccacg
tcagcactac agcaggccct gctatctcct acaccgccag actatccccg 223800acaccagcag
gttccccata tccttcaagg actgctctct ccccggcatt cactcaccgg 223860ccactcggac
attcggctgc ctccggcaga gtttgcacag ctcatcaaaa ggcagcaaca 223920gcatcgacag
cagcagcagc agcagcagca gcaacaagaa taccatgaat tgttcaggca 223980catgaaccaa
ggggatgctg ttagcctagc tcccagcctc gggggacaga atatgacaga 224040gcaacaggct
ttatcttatc aaaatgctga ctcgtaccac cgccaccaca ccagccccca 224100gcatatctta
cagatcaggg cgcaagattg tatctcacag ggtccctcgc ccacccccac 224160ccatggctat
gcccatcagc caccactaat gcattcggag agtatggagg aagactgctt 224220gtgtgagggg
ctcaaggagg gcttcccaga caagagctca agcacactga ccaaaggttg 224280ccacaacagc
cctctgctct tgtgtaccag tgggcctggg gaccctgagc ctttgctggg 224340aactgtgagt
caggcccggg agctggggat ccatccctac ggacaccagc caactgccac 224400cacgttcagt
agaaataagg tgcccagccg aggtaagagt cccctcagag aaagactctt 224460gggagagttt
gctggaattt aagtgtgcag gggtgttagc ttggttctgc tagtattctg 224520tgcgcctaag
caaaacaaaa caaaacaacc ctaaacagac cctaggacca tttgggggga 224580gaggtgaagc
atgtggaaag gcgattggtg ggtgagaagt cacctacaaa atagacagca 224640gtcgacaggt
ggcacccagg acactcctgg tcacaccacg gggtcctaga gtccagattt 224700gcccggctgt
catcagaaag tcgcagtgga aaccgtcagc agtactaagg aaatgtgtaa 224760actgtggggc
tgagagtcag agcctccagc ccgtcctcct ctgtcctgac tgcgagatct 224820agactctatt
ctcatcgtcc tcttgtgtga tagaagggca atggacactg gccctctgca 224880gcatcttgtg
acgatccgag catttgtgtt cgtacagact gcctctgtgt gtgtgtgtgt 224940gtgtgtgtgt
gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gagagagaga gagagacaga 225000gacagagaca
gagacagaga cagagacaac ttgataacta agtatgctgt atactgtact 225060ggggctgcct
ccattttcat ctaaagatta gagtttacct gagtgagttt tgtttgcata 225120gcaaaaccag
agcatcagac cccctgtagc cttttgcttc accctcctca ccacaaccac 225180agagggagta
aagcgactta cccacagagt ctgggactct gggcgtttct tcctcattcc 225240ccctggagtt
acccatatct cttgccttta aaggcgatgc acacaactcg gacccatggc 225300tggccaagcc
ctgcccagca gcaggtgtgt gaagacttgg tgctgtcaga tggacttggc 225360atgtgctcag
agaggaggga aatgtgctgt ataaaatgac agtttaagtc ctgaccactg 225420cagccaatgg
tgtcaccagc ccggagatct gccctccaca tgcatgttga actctgctgg 225480ttgtatttag
agtggaactt tataaacagg ttgtgtgtag aatgagagac acctagcagc 225540attgggggtg
gggatggaac aactttgaag gagcagatct gtcagatgga aggactcaac 225600ttttatgtgt
atgataagga agagactcta aagtgggtag aaatcacggt agattatagc 225660tctccagaga
agactgttac gagagactgc catcacaggc tacctgagca gctttttgtt 225720gggtgtgttc
tggaagaggc ggatgccttt gatggacaca ctgtagaaga gcatccatgt 225780gtggaaagtt
tctgatgact cagctcgctg aaactgcatc gtgcatgcgt gcctccagtg 225840tgcacacacc
gagtgctgct ccatcctttc ttcttattgt gatgctaggg caaaacccag 225900ggcctcacac
acatgctagg tgagcaagct ctacacggag ctgcacccag cctgttgtcc 225960gttttaccag
tgacgcagct aagacttagg agatttataa tttgcctctg ggtcagagct 226020gacaatgact
gccaaaccct gctgccagtc gatcaccacc ccaacaatcc atgaatgtgt 226080ctgatgttca
ggctactgaa gaaatagtgg agcgggtccc agaacagtga agccatgcac 226140tggaggcaga
gatgcattag tgaagcccag tgcatgctgc tgtctttaat tcagatctcc 226200ttggggccag
aggtctgtgt gttaaaagtg attctttgtg gaggtgcccc actgtcctta 226260ggctagcaca
ggttgccttg gagcctacta ggtaagcaca cttccgttta ttctggcagt 226320gaggggtgcc
aagctaaata aactcctact ctatgcttgg cgctctgact caagacatcg 226380gttccttttc
acacccaccc tcggaagtgt gtgtcaaggt accattttgg taggagctgc 226440cctggcctga
cctgacatgc ctgtgaagcc ttcagttgtc cttttcctct ctccccctcc 226500ctctcccctc
tttttaagga cagggtctca ctgcataacc caggctggcc ttaaactcat 226560gatctccaag
tcagctgtgc acgtgccggt cggggttcca ggctatgcac cacaccaatg 226620ttttcagttc
tgggaagaaa ttccagaatg ggctggggag agggctccgt gggtgaggct 226680ctggccacac
aagcctgaca gcttgtaatg gtggaggaag aaaagcagct cccaattcac 226740ctgacctcca
ccctcacatg catcacacac acactcgata atgagataga aacttcacag 226800gtcatttgcc
atgggttttg tgaagaaatg gttctaacag tgtgctgcac tgcaggcgac 226860cgcagaaccc
gcacccatgt ctccctgttt cgacagagga ccttgatggt tcttggtgcc 226920cttccatcaa
acaggctagt ctcttggcgt ttaacctatc actccatggg agggcagctg 226980agtacaagtt
agtgagccag ggtcatgggt gctgcgggaa tgtggaaagc caaagggcct 227040gtcttcagga
agaagagctg tatcagaagt ggcgtggaat atgtgctaca gttcacaaga 227100gcagaactct
gcatttattg gcatttctga agggtgaatg ggtaaggctt accaatgtta 227160gtctaggaaa
cttagatgcc ccgttacccg accgagtctg tgctttcctg ttccctataa 227220agctgtttgc
caccagccag taggaagcca gactgggcag agcactgagc acctactgtg 227280ccagaaatgt
cctccagacg ctgcaagtgt cagagctaac ctgccttcta ttgcctacgg 227340tctcattgtc
ttccacttaa ggagtgaaga taaggtgggt tgccctcctg cagtattgca 227400ggagcttaag
gcttttgact ctgcacgtaa atgaatacaa ctgcacagtc agttgagatt 227460accaccttaa
actcagatag aaaaccgcat cctcttcttt gagcccagtc agcttccagc 227520cttgtaaggg
ataaagtgct gacagccttg ctggggttaa gacagtagcc cttagagcct 227580ctaagagggg
tgtgcaaaca tgccgtttct catttactct taaaacccag taaatgaata 227640aggatgagtc
aacattgaca gattgcacag ttacgcaagc tggcccagag tcccccaggg 227700tgtgggggtg
tgccttggat tctcattgtg cattttgtcc cttacttgtt tgggtactct 227760cccctctgta
ccctctgggt tcttggaaga catagtccct gtattattta tagatccttc 227820tgtaagcctg
gctgttctct tactcctaaa atggcctaaa gggtgccaaa ggttctagtt 227880ccctggtcag
tgggttagtc tttacagcca gccactggtc agcagggctc agctaaggac 227940tttgagtccc
agactcagca cccttccttg tctgactcgt ttacctacgg agccctcagt 228000gcttatcgca
gaccttccac tggtgttagg cttttggagc cctggaacag ccctttcctg 228060tcagataagg
gacattaagg gtaaggggag actgcctggc cgtcaggctt tgtgtactct 228120ggtgataacc
tggaacctgc ctcctgcgac cctcattctt ggcccctgta tgtattcttt 228180ccccatgtta
gcttcctgtc actgggacaa aatacccaag aaaatcaact tatgaggagg 228240gaaggtttgt
cctggctcat ggtgtcagca gtctcagctc ataatttgtc cttgttgctt 228300tggagcctgt
ggagagagac atgccatggc aaggggcatg ttggacaaag ctgcacttta 228360ttctgactgg
gaaacagaaa ggaagccatt gaggacccag ctcccaaatc ccagtccagg 228420gcatatccca
gtgtcctaac ttattttctt ctaaaatttt tctcatttat atttattttg 228480tgtagtgggg
ataagtgggt tgtgttctgt tctctccttc tactctgttg gtcccaggga 228540tgaaactcag
gcttagggta agcaccttta ctcgctgagc catcctgtca ctcccaaaag 228600ggagaaggag
ggagggagtg tgtgtgtgtg tgtgtgtgtg tgtgcgcgcg cgcgctcagg 228660acagttgagg
ggagtcagtt ctcttctccc acctatgggc cctagggatt gaactcaggt 228720catcagactt
gatggcagat gcgtttatgg ctgaatcatc tcagcggccc caccctaact 228780tccctttatc
aagctttgcc tcctaaaagt tccattatat cttcttagcg ccacatactg 228840atgaccaagt
ctcaacatgg gagcctttag gcaacagcca agatcctcac agggccctct 228900ctaacccttc
ccaggttcct ctctagccct tcccagcaca gcttctgagt gggagacact 228960tcattttcct
ctactgcggg gggtcttgtg atgcttaagg ctcaaacatg gtcctacact 229020ctctaggcaa
acattccact gcagagctgt gacctcagcc ctggatctgg tttataatct 229080catttgcttc
tttcagacca aaggctgcta ccctggtaac taaaaattgg gtaacttact 229140tgtttattgt
cctgctctgt ctatcagcag cctgtggggt aggctccaga ggcacaggtc 229200cagaaagatc
cgccacctcg ctcaagttcc cttccacctc ctcaggaagc aatgaagcta 229260gaatcaagct
gagtcttccc accccggcgg tgcctgtggc acctttgcca cctccacctg 229320acagagaagt
gagccctcag ctgggcactc aggagagctg gtcaagtgat agcctcttgt 229380gacctgaggc
ctgggaacat cactcaggaa agcagacagg agggcacaga agggaagtgg 229440agcccacaag
acctttgaaa agcctgggtg ggagcttaga tttggagaaa cctcattttc 229500aggtctaaaa
aaaaaaatcc aaaaggggag aaagagaatt taacagacag gaaaacacat 229560ggggggagag
tgctggtctg gaagagggag tggggtggaa atatcaagat tctgttagtg 229620aagagaggcg
cttgccatct gctcctgatt gatcacaggc cttaaagtct cggcccaagg 229680tcagaggtgg
cagagagtaa acccccatga cctgagtttg agccttagaa agggaagaga 229740aagccaactc
ctgaaagttg tccctcacct ccacatacat gccataactc cacatacatg 229800ccatagcgcg
tgtgtaccca tgtacacagc taacaattgt ttaaatgttt tcaatctcta 229860aacaagggat
ggaaacagag cactacatat atacaacaca tgcaccacat ataccacatg 229920tgtacacatg
tactcatttg catgtactgt gacatgcaca catatgcata tattttaaaa 229980gtaggagctg
ggcgtggtag tgcacacctt taatcccagc actcgggagg cagaggcagg 230040tggatttctg
agttcgaggc cagcctggtc tacaaagtga gctccaggac agccagggct 230100atacagagaa
accctgtctc gaaaaaacca aaaaaaaaaa aaaagtagga acgggatttt 230160ttttaaagtg
tggcctttat agggaagtaa ctaggggtgg ttagaaaatg atctaggcaa 230220gagatactgt
cccttgactg gaagcaggca gtctgggggc tgaggtgtcc accactgaac 230280gagcggactc
tttagactta gccgctgtgg ggccgggaag aaggaattaa gcatgactcc 230340aggaacttac
acctcaaaga ttgggggaag ggaggcggtg ccaaacaagg gctcttaaag 230400gagtagcagg
cttctgggga agttaatgag tttgaaattt aacgtaagtg ttacatacta 230460gtaagataac
caagaaaaaa agttggatct atggatctgg aaccaaaaaa aaaaaaaaag 230520gatttcagta
actccgttta catttagtgt gtgtgtgcgt gtgcatgtgc gtgtgtgtgt 230580gtgtgtgtgt
gtgtacatgt gtgtgcacat atgtatgagt atgtgtgtgt gtgtgatcat 230640ttctcttact
aggcgggttc tgaggataca actcaggtca tcaagcctga tgacaagtgc 230700ctctcttcac
tgaacatctg gctcattcca tccactgcag tacatgagca gtgtggctga 230760agccatggac
ctagatgatg tcaaaatggg catggggagt gaggtcaggc acagctgtgt 230820gcaagcactt
atgaaaggtg aaggagccat aggcagcacc agcagtggcc gtgggacagt 230880gggagagacc
tgggatggca ctaaggcaga ggccaaggcc atggatacag gccagaagcc 230940cctcatctct
agagctctcc atgagctcaa tcaggagctg agcacaagct aagccagcag 231000agtgatgggg
aaagaagaag atgggtatgg cccagctcac accccatagg tggatttttc 231060cttctagggt
aaggagtgtc ttaaacccct atttgctgta ggatttgatg ttgttaggct 231120ggccccagct
cctctaacac ccatgccagc tgactgagca ttggcatttg ggcaaatgtg 231180gtccctcccc
tctcactcat tgtgtcttac aaggggctac atgggagttg gcgtcacctg 231240tcacctggag
aagctctggg cctgctcacc ctgctactct tgctctgtct cctagagtct 231300gtcctaggga
actgcctgga aagaagttct cctggacaag caatggagct gccggatcac 231360aacggccttg
ggtacccagt acggccctta gtcagtgagc acctcaggtc ccggacgctc 231420cagagacacc
acacgatcca gaacagcgac gatgcctatg tatgttggcc cctcctgctg 231480cttagaggtg
ggatggtgcc atctcaacct gaaagcagag tgtccccttc tgccgccatc 231540tcctcagtcc
agccctctgc aagctgtgga gacctttttt ttttctttga ctccccataa 231600cagaccagca
ttaacaggag agtcttgcgg ccatatgtta gacttaggaa tcaaatgatc 231660tgacatccag
ggtcttgacc tctcccagaa atctaaatcc aggcttcaat atatgaaccc 231720tcaatttttg
gtccattcct ggcaactgtt ttgctttctt tggctttctt aagagttgac 231780ctgtcagagc
aagtcttgtc aactgggaca cacccagcca tggtagcacc tgtatgcctt 231840caggcaacca
tttgtggctg ttcaaatgta aatgtgttta agttacacaa aattagaaat 231900ttagttctgc
ggtagtaaat aacagttaca cttcacacac acagcagtca ccatgttaca 231960tgggcacttg
agaacagaac tgttagacct cactgtctat agatgggttg gggagggaca 232020ggggtcccct
gagagtgaca cactgtctgt cactcattgc tgctggttcc actctacagg 232080tacagctgga
taccttgcca ggaatgagcc tggtggcagg caaggcgctg agctctgccc 232140ggatgtcaga
tgcagttctt agtcagtctt cactcatggg cagccaacag tttcaggatg 232200aggaagatga
aggtaaggcc ttgcccatgg gcaccccggg gcagtcttct gtggaaattg 232260ttcactggct
gaggtgctac gcacatgtgc acacgttagg ggctctggct tctgtcagca 232320cagggacatc
acagtccaag ttcagtgctg gagcaggatg taccttcaac aatagccctc 232380tttcagcttc
tccttagagg gcttcatatc cttgtagaac atttatttct atgtctttgt 232440agagccaggg
tgggagacca tgatagagcc tggagacgga caggttcacc ctttctaagg 232500tccacaggca
aagcctagga agtcttcatc ccaagtcttc acctgtgagg acatcaagag 232560agcagtgccc
atgtcctggc ttgggtccta aggatgctgg cctcctgagg tttattagtg 232620tttattagtg
tgatgctcaa gagaaagtgg cctggcctgg ctcctatagc actcactaca 232680gttatcctgc
cccctaacca caagaaaagg ctcttgaagg gtttttcatc ttcaccccca 232740tatgtcagtt
gctcatgagg gtggcgaaag gaaggggcag gtggtcagga agggtcccta 232800acatctgaag
ggcctgctgt ggcctgagtc agagctggac tcaggctggg ttgctagaca 232860agacctcccc
agcctcctct ctcctgtccc acttgctccc ccacctccac ctcacatgtt 232920ctttttggtc
ttgcagaatg tggggtgagc ctgggccacg agcatccagg cctgggtgat 232980ggcagccagc
atctcaactc ctctcgctat ccagctacgt gtgttacaga catcatgctc 233040agccacaagc
acccagaggt ctccttcagc atggagcaag ccggcgtgta gcaagatatg 233100gaaagtgagt
gccaccctgc tcaggcccag gcagccctgg ggcccagtgc cagcccctca 233160tagcctcaat
gtgttcattc cttgtgtggt accccactaa acttgagcga cactcttttt 233220gtgcaacctt
ccccgtctgc ctgtttcttc attaagtact gtgttagttt tgaggtgggc 233280tgaggacttt
aatttaggga agaggtacat ggcccacctc atgttataga tgctatggct 233340ttaatgagat
ccaagctaca gttgcagagg ccagaggcca atgacctttg gccagctctc 233400taaagctagt
ctttacactc catcctgaag agtgaaaccc aaccagaaaa gggaaaaaga 233460gcagatccag
tcaggctcct tcactggtgg tttttattgt ttggttttgg cattttggtg 233520ctaagcatag
aacccagggc cgtgtaagcc ccagccccag cctcaacccc agccccagcc 233580ccagctggac
tttttagggg gtaaacccat gctgaaaaga cagaaggctc accggccctg 233640ttggcctagc
agaggtcaca tggatggtga gtactagtgg ctctatctct acagagacag 233700aacaacttga
ggaaggtaaa gccacaggca gaggcatggc agagcctcag tgtggcaaga 233760ctcatacagt
gacaccaaga aaagacttca ctgagagcct gcatgcctgt ggctcactga 233820cagagcaggg
catggacaca tagggccctg agtcccagcc ctagtaccat tagaaagggt 233880ggggagaaag
ggtgaagtca tgtccctctc cttcaaggtg ttcttgtctg cttcgtaggt 233940tcgagtacag
ctccaggagg aggctgagtc tagaccaata gaccaacagt gtccaacagc 234000gccgcaccgc
tcctccgtct gtgtctccac cacaacagtg cagctccttc ccctacacta 234060ggcaccagta
ggccggcgct tgggttgcga gggacatttg ccatgtttgc ttgtatgacc 234120aaggcaccaa
ggaaataaac aggaaatcag tgtcctccat ctttcatgag ccagcatctg 234180gtgtgcttga
gttgagttct gctgttagga ggtttgcttg tgttttgttt tggaaatttt 234240cctttggaga
taacttattc tctttgcctt gcccacccct acccccttga gcatattccc 234300ccccccctct
cgttttcacc taccatttct gaggtagatg aaccagaggt tagtattcag 234360gggctgaacc
tcaggaccct cccttccaca gcctgtctca gaccagactc tctccctctg 234420ccccggtcta
ccaggaacaa atgctagacc ggagcttggt ggccaagaaa aggagaggag 234480ggggcagtgg
cccctgcctt tggagattgg aacagaagaa aaaactgagc ctgggatctg 234540gcagaatctc
ctgctggcct ctactagaat cctatctggc ccagcagaat tccatcagat 234600cccagcacag
gccggatggc ctggtgctga aggtttgcca tccagaatag ctcagtgtag 234660gcccctctgg
tgtgtggtcc agttcccctc cagtcaccaa ctggttcccc ctcatgagtg 234720aacacccagg
agtggtgcac tgtgctgttt gtgtgatctc cattcttatt ctctactgcg 234780ttgtaaaaag
ggccgttggt ccatttgtgt gcacacgtat gagtgtgtac atgcccttcc 234840ctgcggcctc
tttgtcacag acaagaattg gaggctgtac tgggtctctt aaccttctcc 234900tctccccagc
atcctcggcc cctatatttt aattcttgat catgtaggaa ttgtttttga 234960taaatgttga
tattattgtt attattgtta ttattaataa agacaaaaag gattttgttt 235020atttgtttaa
aagagaaatg tttaaccaga ttctgtgctg ttgaactgtg gcttgcaact 235080tctgtttgaa
gtgttttcct tggctttggc atcgtgagcc actctcctgt gccagcagcg 235140gatgcagtgg
cctcccttcc ccagccgaag cagcacatag gcagtggcta ctgtccttgt 235200cacttccttt
ctctctgcag tcagaaacca aagtctgggg ccaaacgagg ccggcccggc 235260ttctcttctg
gtcttcaaaa ccagagaggg atggtccctg ctctgactcc cagccctcat 235320ttctgagagc
caggggccac caacctctga gtatgcacag aagaaagccg ctgcctgcca 235380tggcatctgg
acattaccag cagggtccct agccatttta tccttccgca ccaaccctga 235440aagcttgcct
ctttgaacaa atccattgtc tcttgaatgg atttgttttc aatgtgagag 235500cttggctggg
gacctgtttc gtggtcccat gtcctccaat ttcccctcca cttcaggtgt 235560cactaattac
tagccagaag atgtctgact cccaagaaag cttgacaagc cattgtcagc 235620ttccaagctc
agtccagctc tgatactcca gccccgccct gctgctcccc acgctcagcc 235680tgacctgttt
acgtggtact ggattgatgg aagagcaggc accaccctcc agagccaccc 235740agacgaaagc
cagtgagcct attaaccgtg ccatcttgcg aactattttc aagatcacca 235800ttgctttata
ttgtagtaac caatatgcgc agtatatgtt gaatgtatat gaatctactt 235860tgctatttct
gttctttgaa aatgtaagaa gtatttttcc tttctcattt ctgttgatct 235920aaaaatgata
ataataataa taatctccag attcaagttg ctaagagctt ttgtccttgt 235980ttgtgtggga
catctacaac ttagtgactt ggttggactg taggaggttg tggaaataaa 236040aacctgatta
tgtactaacg ctgatatgtt gtttgcctta cggttcagag tctaattgag 236100agaatcacat
ggggtagggg cagaggtgac ccaggtgtct ggagaagtcc ccagacttag 236160ggtggggctt
ggagcagcac attctcacct tgccttttgg cctctgaacc tggcaaatca 236220gactcacact
gtgtccaggc atccgtgtgg actctaaccc ctcagaaggg acacatttgt 236280gtttgcagag
ttgggtggga aaaggattcc ttggggtcct cagaaggaga gccttgcatt 236340gaccctggct
ggaaccttta tgaggtggcc tccctcagct gtaggacaga agggcttttg 236400gtactgtttc
ccaatgtctg ttcctggatt ccaggtggag ggcagaattt ccaacagggc 236460cccaggctct
gctgaaagag ctgaagtcac acgagaaaaa agatcaatga tctggggaat 236520acggagattt
gtagaaagag tgacagaggc tggaaggatg gctcagtggt taagagcacc 236580aacttcctgc
aactcacacc acacagaact ccaattccaa ggacccgaca tgcttcccag 236640gctcctgtgt
acagataaca tacactcata cagatagaaa actctttagg cagggagagg 236700cgcatataag
aaagcctttg aggctagaat tgcaatgaaa ctgctcagag tggaaggtgc 236760cttctcagcc
cctggaggtc ttgaaggtgt acgcaccgca cagaggtgag ctggctttgg 236820aaccagtgat
gggccctaag gactcccaaa aggtcaggac acctttcact gatgctgtgt 236880ctgcaaagtt
tttggctaga ggtcgggtag gtacccagag gcagccagat tgactctggg 236940atctgaacct
ggacatctct gccctccaag aaggaaagaa agacttcctg actttgtact 237000ggagccaggc
cccacccact taaccacgga gactttagtc tcctgagcag gaggcaggaa 237060catcattcag
agctgatgac agtgtccttc caaacaggaa tcactgggga tccagtctgc 237120ttagggagac
cctccccagc cctggctccc cattcctgct agcactaccc cttgttgggt 237180acatattccc
agaaggggct ggcaccattg aaggcctgcg cctttctgtg accctttgcc 237240agtctgagaa
gctttggtgt atcaatgtta ttcatttagt aaatgtttgg tgtctctggt 237300gccagtccca
ctaaaggaca gagtccttgc actgccctgt gcaggtgatc tgtgctgaga 237360cagaagttgt
gaaatgggct acattcgctg ctgctgaagc taccagcact cccgggatcc 237420caggccagca
cttgctggtc caatccagga gtcactttgg aggttcccaa gatgaggggg 237480tgaagggtag
tgagagaaat gccaatgata ggcactatct tcactccctg gtcacccaac 237540acctctaaca
gcagccaacc tgtctcaatc tgtgatgagc ccatttgact cttgatctgt 237600ccagaaagac
ttcctgttca gaacagtaag tagctattta gactagttta aaccaaatgt 237660ctcctgataa
agtaagtcac tagcaagtaa gtatggggtg tgggggaggg agcatggagc 237720atacacctat
aaccttagca tagaaagcca aggcaggagg attaccacaa gtttgagacc 237780agcctggact
atataccaag acaggagcac acttattgct cagtcaggtt gtcccagagt 237840cgtctaccgt
gatgtcatgg attccagtcc ccaagccatg tccctggaga gagtacaaag 237900gctttggaag
tgaagaaatc accatcagag aactagaggc cggacccgat ccctagcccc 237960ttgggcactg
tctcaaagct ggggggcaag aatgttctta gcatctctga gctgccgttt 238020tttctgacag
gcaaactacc aagggggtga acatggcgtc cagccttaca ggggtgtctc 238080aagtttactt
taaatgagtt gcggagcaaa tgttaggttc aattaggatt agccagcacg 238140gtttcagtaa
cgagccagaa agaaagatag gactgtggga agcatcctgg aaaccaacag 238200acacccccac
ccccacccca cccccaaaag acctaaaaaa ctactcctgt ggaggccacc 238260tccctctgag
tgctcccaca gccctcgggg gctggtttca acctggaaaa gatgtcctgc 238320atcacagcac
ctgcaagcca gacacctgcc ttaccccatt tttgctgcca gcaactgggg 238380tcacaggcta
tggcctagta acagaatgtg ttcgtggcag tgacctcagg agtctgggat 238440gcagaacact
tgccatttgc tgttggtcac ctttcagcag ttttgcttga aatgtgttca 238500gacttcacag
acaacacaac acaaataaaa ctctggagtt cagaagctca aatcatggct 238560aaaagcatgg
gattgtcaga gtgatattct gtctgaaaac tctttcattc agagaaaacc 238620tgcattttct
cttctctctt ccagcaccca tggatgggta gccgaaaccc gcttggctca 238680tctgcacact
cagattgctt ggtctctatt tctgttctca agtttctcca tggttttggc 238740ccttctgcct
cctctagcat attgagagac ccttgtgatt actgtgccct ctggatatcc 238800caggctaccc
ttgagttcaa gtcccctaat cacatttgcc atgttagaca ccacgcacag 238860gttcctggac
ttagtaagtg cacacacatc ttttccattt tgcttcccat acagtgactg 238920ggatcataag
gaagctgtgg catgctctgt cattatcttt ccttagcaga taagagaccc 238980agggacggag
aggttatgta acctgtccgg gtcacctgga gaataagttg cagatcccag 239040aaccaaggtt
ctctctggtt gcaaagcctc ctgggatggg agcagcctgg aatcccagcc 239100actccctgaa
ctggtagaca gattccaagc tggtttctag ggagttgggg agtttcctag 239160ggagatgggc
agagtacatt cctgccctgg gtcccaaatg cagagacctg ggcgcaaggt 239220ccatccttgc
ctctaaggct gagagataaa ggacacagca aattccttcc actctcaaca 239280ggcccttatc
tagaaggaag ttcatggtag aacctcaaat agatggtctc aaaagttcct 239340cttagcttga
aaactcactt tccataatgg gattttagag atgatctgtg gtttttgttt 239400gtttgtttgt
tttgttttgt tttgttttgt ttttagatat tctcatatag cccaggctga 239460cttcaaactt
gctatatggg caaggctgtg gttttgaact ctcaaccctc tgaccttcca 239520agtgcaaaaa
ctggccaccg tactcagccc actctacaca gctacccagc tctcccatcc 239580tggcaagtga
gcctaggccc tcaccactct gggaagacat atcgtcactg aactacatga 239640ccccttttag
tggtcatggt atatggtgag gttttctctg gaagggaggc tgaataacag 239700catctacaca
taacaaaaac attggcaact ggggctggag agatggctca gcggtttaag 239760accactagct
gctcttccag aggtcctgag ttcaattccc agaaaccata tggtggctca 239820caaccatctg
taaaggaatc tgattccatc ttctggtgtg tctgaagaca gagcgctcat 239880gtacctaaga
taaggaagaa aggaagggag ggaaggaggg agggagacaa ggaaggagct 239940aacaactcca
tgttggcctc tgtcatttct tctgaagcat cagaggggtc ttcatcctca 240000gcttggggat
atgagcctgt ctgcatctca ctcaggctga cacctcagtt gtttttggat 240060ttagggttgg
gaggctggct aaacatgtgg catctggaaa gacaaatccc caaacctggg 240120ggaccagggt
gaggtgaaag ggggaacccc ttggaaagca aaaaaaaaac tttggggtgg 240180ggctgtgagt
gaaggagccc acaattcctc cctccctccc ttgttccagg ctcagagggc 240240actagcaaca
cagaggagtc caggagtggg ctccatgaga ctatcttgaa gaagacatac 240300acctcgggat
ggtgcaactg ccttacccct ggggacccct ggagtctgca gccaccccct 240360gctgccccca
cctgaaccct tgatcccagc tcggcagccc ccgcagtttc ctgtttgccc 240420actctgtttg
cccagcctca ggaacagagc tgatccttga actctaagtt ccacatcgcc 240480agcaaaagta
agcagtggca gggccaggct gagcttatca gtctcccagc ccagcccctg 240540cccacacaca
tatatagacc agggaagaag agctggacac ccagactgtc ggagagctcc 240600ggggaggtaa
gtgctgctac ctgccttcgg tggctctggc tccatagcgc ctcccagttg 240660atgctccact
gtccaaatca ataccgtgga tatctcgcac ctttagccat tctagccaat 240720gcttccatgg
gcttgaattg tgtgtggagc ctttccatga caatgcctcc cttcagccca 240780gccctcctcc
tccttcttct tcttcaggtc acccacaccc ttcaggatga aagctgtggt 240840gctggccgtg
gctctggtct tcctgacagg taggtgcctc ttgacctgcg tgggactacc 240900ttcctgggca
cagagaacag aattcccact gttctcttcc ctgactccga gtctaaccta 240960acatgggtct
cccctccatc cccagggagc caggcttggc acgtatggca gcaagatgaa 241020ccccagtccc
aatgggacaa agtgaaggat ttcgctaatg tgtatgtgga tgcggtcaaa 241080gacagcggca
gagactatgt gtcccagttt gaatcctcct ccttgggcca acagctgaag 241140taaggaaaga
cctagcgtgg ggcctggagc aggtcaaggg ctgcccatcc agggtgggca 241200gagagaccag
tgagaagatg ctggaactga gctggctagc ccttcacggg ctttcctacc 241260agctgggcac
catggcaggt tccagtggag gactagggat gggattcatc tggctgttgg 241320gtaaccacag
cccctcattc agcctatgag tgccaaatcc cttttccttg gtaaccccca 241380gtactggtca
gacagcaccc aaaacaaaac aaaacaaaac aaaaaacaaa aaacgggact 241440ggccttgtaa
ccagcaccga ccacatctgt gttcttggtg ccttccgcca tgtgtacaga 241500ggaatgtaaa
gggaaggcag tgagttagag ggttgcatgt tcggggaaac taggaccata 241560gcaactgcac
attaggggac aggtggcacc cagctatcat gtgcatggat ctgcagacca 241620ggggcagcgc
atgatgcctg ggctcgtctc tcagccgctc tcttccccct ctagcctgaa 241680tctcctggaa
aactgggaca ctctgggttc aaccgttagt cagctgcagg aacggctggg 241740cccattgact
cgggacttct gggataacct ggagaaagaa acagattggg tgagacagga 241800gatgaacaag
gacctagagg aagtgaaaca gaaggtgcag ccctacctgg acgaattcca 241860gaagaaatgg
aaagaggatg tggagctcta ccgccagaag gtggcgcctc tgggcgccga 241920gctgcaggag
agcgcgcgcc agaagctgca ggagctgcaa gggagactgt cccctgtggc 241980tgaggaattt
cgcgaccgca tgcgcacaca cgtagactct ctgcgcacac agctagcgcc 242040ccacagcgaa
cagatgcgcg agagcctggc ccagcgcctg gctgagctca agagcaaccc 242100taccttgaac
gagtaccaca ccagggccaa aacccacctg aagacacttg gcgagaaagc 242160cagacctgcg
ctggaggacc tgcgccatag tctgatgccc atgctggaga cgcttaagac 242220ccaagtccag
agtgtgatcg acaaggccag cgagactctg actgcccagt gaggtgcccg 242280cttccactcc
ccacccccgc attggctttc ttacaataaa cctttccaaa atggaatagc 242340ttctttcttt
gggggacata gggcgggcgc taaggggaca tcaagggacg tgagaacatg 242400gtgccgcact
ggggattcct ttgtacgcga ctactcagct cttaacgctc actcaagctg 242460ggcacctggc
tggttcaggg tatgagacag aatcccttcc taagaaggct ccaagggaaa 242520tggatggcca
ggcaaagcaa caaggaaccc caaaagggcc ccacagaggc tcagaacact 242580agtgctgtaa
accaggatga gagtgtctgg caataggact ggctttgaga ccgctggttt 242640cttgtgctag
ccgagtttcc aggtggggtc cagagggtgc aggacgggag cctcttccac 242700tccctagagc
caggattcct tcaggagcca ggaagattgg agttattggg tgggtgctaa 242760taaaaagcct
ggagctgaac ccgatctcgg taaacaattc cctttgatct ttccctccgg 242820tgcacccaca
cagtgtgctg aaagggtcaa ggctgcagct actctacctg acagttggat 242880acaaaaacaa
acaaacaaac aaacacccct ctccatgatg ctggtgacca cacatttact 242940agagaggcct
tcatatccat ctctaaatcc tgaaggatgg cctttaagtc cacaccagtt 243000ggggaagctg
agctgggagg tctgaagtta gtcactgcag aaaaggtggg tcaggatgtg 243060ccgttccatt
ttaaaacaaa acaaaaacaa aacaaacaaa caaaaaaacc ccttttatta 243120catggggctg
gtaaggtggc ttatcaggta gaggcacttt cggaagtctg agaacctgag 243180ttcagtgctt
agaagacaca cacacacaca cacaccccac aaatataaat aaaggtatat 243240aaaatattta
aatttttatt agacttattt agtgtgtgtg tgtgtgtgag tgtgtgtgtg 243300tgtgagtgtg
tgtgtgtgtg ttttcacgtg ccacagaaca tgtgtggaga ttagaggaca 243360atttgcaggt
atctgttctc ttttccacca tataggtccc aaagatcaaa aactcaggtc 243420accaggatta
gtgtagcgag cgtctctact agctaagcca tcttgccagt tcttgtttgt 243480atttatctac
tagctaagcc atcttgccag tccttgtttg tatttatttt atttggagac 243540agtgtctcca
ctagcccagg ctagactcag atgagctctg atctttctgc cccatctccc 243600aagtgctggg
ggtttcaagg atggtccacc actgttactc tgtgctgaga caaacccaga 243660gctctgtgca
tgcaaggcaa gccctctacc acctgagctg cctgccaagc ccagactgtt 243720cattgtatag
acttgcccgc tatggagtgt aaccaagcac tcatgttcac agggttgagg 243780atgtctgcag
aagcactctc acaccaacag ccttcctctc atctgcccct cttcatgcct 243840gtgttggtat
gcaggtggtc tccatccatc cccggtgtat cttcatgagc ccctggctga 243900aggggtgagt
ttttaaatcc acaatcatgc agagccacag cagacattaa accaggtttg 243960ggtaggaaag
tttcccggtg tggacaatga gacttctggc tcttggtgga caggaagaga 244020aacccctatt
ggatttccag agagaacata gtccagtctg ctggctgtgc caatgcagtc 244080tggaaaggag
cttccaacac ctggcagagg cttttccggt gccagcaacg tggaaaatgg 244140aaagctggcc
ctgcagtgtg ttttctcctg atccggggca gccactggca ctctctgaac 244200attagtcttt
tactctataa tgtgcaagac ctgttttgtg acactgggtc tctttgaagt 244260gagtgtttgg
gggtggcagg aacttagcaa gcagcccttt tgggattctg aggacactgg 244320gtctccattc
cagtctagaa ggtcacctag tttagctatc acagtgagga ctgtttacaa 244380ggggtgtgcg
catgcggcac ctcatgcttt tagacactac catttcattt ctacaacaaa 244440ccttcagggg
aggggcaggt cctacccact ttattcataa gaaatggaag ccgctacact 244500gcagtggggt
tgagacttat ccgaccaccc tcccaatctg cctccttcct ttccgcctgt 244560ttaaaggggc
caggcagcct gggctgtgca aaccagctgc acggggttgg tgatcatatc 244620tgaccttaag
cctggagatg acataagact gctagctaga cagatactac actccagcca 244680cgtcgtccac
gttgtcctgc ccttgacagg tttatcacag attgtaactg caaatctgtc 244740gttacctgat
ttgatctttc ccattaagtc aagcagggaa gcggagttag tcccacgtac 244800aaaggaagaa
gcaccccaga gaccactaaa gaggtggatg acctacagcc ccaggtccac 244860cccttcaaca
ggcctagctc atccccatgc ccagacgtcc aggcacatgg gacacccact 244920aacagcagct
tcttatccag ctttattagg gacagcatgt ttaggtgaga tctagggagg 244980ggtgaagaca
tgagaacata ctttcccctt aaagcaacct tcaggggcca cctggcaggc 245040ctggaggggg
gcagcaggat ggaggaacag gcacatctgc aacacagaag tctcacgact 245100caatagctgg
agttggttgg tcctcagggt tagaatccca gaagccggtg aacttgtcag 245160taaacttgct
ccagtagcct ttcagggatc tgaagtgatt gtccatccag cccctggagg 245220ttaaagcagt
aagaggcatc cataggagag agggagagag agagagaggg agagagagag 245280agagagagag
agagagagag agagagagag agagaggtgt gtgtgtgtgt gtgtgtgtgt 245340gtgtgtgtgt
gtgtgtgtgt gtgtgagaaa agctcccccg tgggcagcta gacccaggac 245400tgcacgcagg
gctccactgg ctctctcagc caccagcacc accttgccta tcacacccca 245460aaatcacctg
cagctaccta agaaacccca ccttcatcaa ggttggatca gaacctcagt 245520gccttccatc
caatctcctt tcaggccgga ggcaccaagc accggggagc tggatactaa 245580ggtcagctac
aatgcagctg cctgtatagg ccatacaaat cactcccttg aggtacccca 245640tccctggctc
taagtgggtg aggcagaggc agggccagtc tctcatttga aacattactg 245700aatgacttct
aagctgtgtg atctaggcca ggttatctaa ctctttatca tcagcaaaac 245760cgagtatcta
atatcctccc cacagcctgt tctggggata gagactgtca acatcttttg 245820ctacataggc
aactaaacta tcaaatgtca gccaaagcca ttggccaggg ggtgatattt 245880catagtgggc
aagatgccta cctcagactg agcccaggga tagaaacagg gcagactccc 245940accctctaac
ccccaacttc ccacctcact tcccaccact accccctgca tacaggcaga 246000aaccagagca
ggtaggcctc ccatcgtgtg cgcaggaccc agaggagaaa acctgcagcg 246060aggctaaatg
cccctcaggc tgctctgagg aaaagcagag aagataggag aaggctgctt 246120gccctgcctg
tcatcttggt cacagtaccg aaaggcctca tgagggacca gaggctcggg 246180caggtcccag
gccctggtaa acttggtgga ccacagtctc tgtgctaggg tctcagcacc 246240agggcatgag
aggagaagac acaggaaagg aggccagtgt gcctacctgg ccaccacagc 246300tatatcggac
tcctgcacgc tacttagcgc atcctggacc gtcttggagg cttgttccat 246360gtagccctgt
acagagccca gcagcaagga tccctctacc tcttcagctc ctgcgagaga 246420gcagagttgg
gccacgccag ccctcagctc ctgcccagcc accacttctc agggcagggc 246480cccctgacca
gctcccactg aaacccagcc ccactcccac catcttacgg gcagatgcca 246540ggagagccaa
gagggccaca gtgaggagcg tccggggctg catggcacct acgtacctgt 246600gggaaagcat
ctcgtgagaa ggtactgtgg atctgccaca tctaggtcct ccccttgaga 246660atgccatgac
tcctgggtca tgaatcccaa gcctttctcc cactgatatt agatagagaa 246720ctacagtaga
cccagccccc caagtggggt ggaaggtgga gtatagaaat actctgcaga 246780acgggacatc
tactctaata tgctgagaaa caataggttt cttttcctcg ctaggactca 246840gttttttcag
tcctgggtag gcatggatac caaaggcttc taatagctca gagcaagcta 246900aacaagggac
agcatgaccc aattgcaggc agctctgcca ctacccagtg caaggctttt 246960ggcccatagc
ctccctttcc ccagcttcta gcccccccca caccaggaac ccaagggtgg 247020agaccatgag
tcccaagcct tctgtgggct agatggctgg gtggtgagag cttctccctc 247080cagctctttg
tttcttccct tccttcctct cctccccagg ggcattacct ggagtagcta 247140gctgcttcta
gggataaaac tgagcaggca agcggggagg gctgtgacct gttttatatt 247200ggctccagga
tgggacagcg ggcacagaag gcccagtgag ctgggcaaag gtcacctgct 247260gagcagtcca
gaccagagcc tgaggcagga aggccatgca gccatctgcc agaggagttg 247320agaaatccct
ctgagattgc ccatgctttt cacggccacc tccgccacca agggatcagc 247380taccggctca
cctagatgag gtcggtgaga caggaaaaga caggggacaa gccttggacc 247440tcaggcctgc
tttacagcct agagccagtg acaggctcct tcacagaagc cacctgaaag 247500ccttccagta
gaatggaatg gggaatctgt ggtgccactg tggagcaacg gaggaagtgg 247560ggtgggaggg
ggcagagtga aggttacatg cccccacact gacctccacc tgtgatccca 247620acagtctcct
ctgccgtagc tgggcaggga ttagtgagag aaggacaaag gtcacatgga 247680acccaaggcc
ttgcccctcc ccaactcctc cacaggcctc ctcttgccct ctggacctat 247740cgttagtaat
cctgagatag gagcagggcc catggctggg tgatatctga cccctacatg 247800agccctatct
atgagaacct gcaagcagca aggtatagac agggcattca caaagaaggt 247860gaggatgaag
gaggcgctct ggggcaacta agatagtccc ctgagctagt actgagaccc 247920acagcctaga
cagcaacaga ggacatcatc ttctggatgc agactttgga gccaagaaat 247980cctaggttta
gggttttttt tggttggttg gttggttggt tgattttttt tttctgagac 248040aaggtttctc
tgtgtggccc tggctgtcct ggaactcact cttgtagaca aggttggctt 248100tgaactcaga
aatctgcttg cctctgcctc ctgagtgcta ggattatagg catgagccac 248160tacctgccaa
aatcctaggt ttaaatgcta cattcgggac tagagaaata ggccaattgg 248220acaaaatgct
cgtcttgtaa gtaggaagac catagttcaa tccccaaacc ccatggacag 248280cataagtgca
gtagtgtcca cttgtaatcc caagcactgg ggacagggag ataggtagca 248340ggccaggagt
tgatgtccca ccagcctagc ttcttcagtg agccccagat accactgaga 248400gactctgtct
cataaggcaa ggtaaacagc tcttgaaaaa tgatacctga gccaggcagt 248460ggtggcgcat
gcctttaatc ccagcacttg ggaggcagag gcaggtggat ttctgagttc 248520gaggccagct
tgggctacag agtgagttcc aggatagcca gggctacaca gagaaaccct 248580gtctcaaaaa
accgaaaaag aaaaaaaaag tagaaagtag aaaaatgata cctgaaactg 248640acctgtggcc
cccacagttg tgcacatcac acatgcctat tgacctgcac aaacgcctaa 248700gcaactgacg
cctttgaggc tgacatgtag ggtctgtggt cagaagttaa cgggatggga 248760cactgacttc
ccagcgtgtg gagaaacaca cagcagctgg cccagggaag gactcagttt 248820ccctacctcc
caaacactga cagcccagcc agagacagca ggcagtttcc atgcagaaac 248880agggcttgct
gcaggcagca acctctctga atgaaatctc agcctgagag gagcctggct 248940ttcccctcag
aactcttaat ctctgtcttt ggctgagaca cgaagctcat ctatcagaaa 249000tacattcttt
tgatataaga ctgttgtctg gggtagctgt gatagtgttt gcttaaaaga 249060ccagcactca
ggaaaatagt gttagaggtc agcctggact aaataatgtg actgtctcag 249120aacaactcaa
aacagtttgt ttcctgttaa aatgtaagtt gtccgaatta tgtagcttag 249180acattactaa
ctccgtttat ggctaaaaac caaaggccca gtggggtaga gactgctcaa 249240cacatgccac
ccagcagtgg agaagctggg tctcagcacc tgagctggtc ctcagcaccc 249300atttataccc
aagcttcctc tgagaaaagt ccctggcgaa gctgagaggg aacaaaggtg 249360gtaccagggc
ggggcactgt gtgtcgtggt ggagggagat gccatgttct tttttcttct 249420cagcctgttt
cttgttccta ggcaaagggc acagcaggga tcagatccca atctggggtg 249480tgatatcaag
tctttggccc tgagaatgat ttaacaggct gactgggtca ttgtccattg 249540gtagggaggg
tctgggaagc ctgtcacctc ccctgtatgt agaacatggt cactgaatca 249600agaaaagtca
aaagatgcca atagagagtc ccagccatgc gatacttagc tgcacagaaa 249660acttaggtgt
atgaatccca cagagtggtt ggcaggcagg tgataccttg gaacctgggc 249720tctgggactt
agtcccttcc aaaaaccctt gtaccctctc agccatagga gccttatggt 249780ggcctcttgg
tggctttctg gcctagggtc ctctggggaa aggacagtgt tcttgactta 249840cagacccagt
cccatggagg aaggtagcag tggggggggg ggggagtttc ttaatttctt 249900ttcctgttgc
tatgatacaa tatcccgacg aaaacaaagt gaggagttat cctggctcac 249960acatggggag
ccatggtggc aggaacacga agtagccagt cacatcacgt ttacaactaa 250020aagcaaagag
ccatgcaaag ccagtcctca gctcggctcg ctttcttcat tttgtgtggt 250080ctgggatcct
tcatccaaca accccccccc accccctcag gtgattccag attctgtcaa 250140attgacagtt
aaaactaatc accacactgt ggaagatgtc ttgaacattt gggctgagaa 250200cagccctcag
gagtggcttg ccagccctcc tctgtttggc taacagcagg ttgggtggat 250260gagagcccca
gggctctact tggatcctat aggcagatgg atggtgcaca gctaccaatc 250320agccttacta
gccatgagct ccgtgtgagc acaggcagag actgagggtc agacagagac 250380gtgagttgcc
aagaccactt gaccctctgt gcccgaggct ggcataaggt ggtctgctct 250440ttttccccag
aagctgacac atagggttct cattttgcct caccctctat gcaaatcacc 250500agcagatgca
tatgaagtat gccccagtct tggagaagtc aatatgatga tttatgacgc 250560gccaggaggc
aatacaacct ccctgtaggg gctggtgcat acgtgagtgc tagccacaca 250620tgtgtgtacg
atgacccagt ctcttagctc agagccaact tctgaacccc tggacaactc 250680agatatctat
gcatatctga cagcccgtca ctggaaacca cccttgaaca aacttaggta 250740acacaggtct
tctcagagag ggtatgagtg ggcaagcacc tctggacctg tcccacgctg 250800ctggcacttg
agagactcag tctgcaggtt caggaggtgg aactgtagct gagatgtcct 250860acgtgactca
tcccccatca gttctgacct ttgggcacag cacaggctgg accaggcatg 250920attaggtaaa
gcaagatgag gaccaatggg tcaatggtac acagagagaa accgtacata 250980gctaatattc
aacgaggaac ctaaggggag ccagactatc tcacagaatc ttcacaacga 251040agactcatcc
aagaccacac agcacagact gtgtgggatc cacgtgcaaa cacagggagt 251100cgactccaga
gcctgaactc agaaaacatt gaaagaccac caagatgact cagtgaacaa 251160agtcacccag
cctgatgaca tcagttaaaa ccctagaacc caaatggtag gatgagagaa 251220caaacctctc
cagttctcat ctgacctcta tacatgtatt gtgatgtata catactcacc 251280cctaccaaat
attagtaaat aaataacatt atcactatca tcattatttt tgtttgtttt 251340gttttgtttt
gttttgtttt gttttgtttt gttttgtttt gagacagggt ttctctatgt 251400agccctagct
tcctggaact cactttgtag actatgctgt ccttgaactc acaaagatcc 251460accaatctcc
acctcgtgtg tgctgggatt aaaggcatgt gccatcacac ctggcataaa 251520ttaattttct
taaactcact aagcatggct gtgctaggaa ggaatgagct cggggaagct 251580cgagccctgt
ggggagccat gcagtgcagt ggggcccagc agaggagcac aggtatccag 251640ctgtcttcag
tcccatgaga caagctaatc tggacacatt ttaaaaaatg gatggcaaca 251700cagcaaatca
gactgggcac aatcgtggtc tattctaatg gctgtcattt cacaaatgct 251760gtcttgtgga
tggcagtcaa tgggacagta tgatggatgc cctcatctag tccctggtgt 251820ggtccactga
ggctccacac tgaccacagc ctggcatctt gcctgtggat atctgctgca 251880attgtatgtg
tggacacatg tggagtctca gtaggagacc tcaaaaaact cactttccac 251940agcagtgtct
gtcaccttct gtgggggggg ggggggtggg aagagagaga gagggagaga 252000gggagagaga
gagggagaga gagagaggag tcactctgca tggctcttgc atatggctga 252060gaacagtggg
gcagcaatca agccttagcc agccctgctc tctcactgtt gcctctagcc 252120cacttggtga
ccctctgagg gaaagggtgg ctctccctct gccactgtca ggagaggatc 252180aggttctctc
cttccttcct gtgctgatgc acacagaaaa tcattgtcat taatttcagc 252240ccttactctg
ggctaagctc cctgcagcca tctcacaagt accacctaat ttaatgtaac 252300aaactacaca
ttgttcaaaa gagaaacttg aagcttcatg ataactggac ggaggtgagc 252360cagcttgaca
gtcatgagat acaaagccca ctatgattaa ctcctttgat cctgggttct 252420gatcctctcc
tgaccaaggg tatcacagac acctcaactg aggctcactg tctgctgcag 252480ccctatgcca
tctctgggcc tggtaccatc tctgtagctg atgttctgag acaaagttca 252540ggttggtggc
agctgtcaga ctggtggctg tctcactggg gtggaaagag gagacctgga 252600ccttgttctc
tcagactggc acagacccag ggctgccaac cgggcctctg gggcctcagt 252660tctgttcagg
gactccccta gactcccagg ctcattcctc ctgaagtttc tggctatcct 252720tcccagcctc
ttggacaggg tggagccaac tcaagaagac tgcttccctc tgctgcctgt 252780gtgctgtcag
cttccacgtt gtcttagggc cactaaagtc caagaggcct cctgggagtg 252840tgtcaccttc
caacgtggag tcacactggg gaggaggcgg ggagagaggg ctggaggggc 252900tttaaatgag
tggctggcct tgcctgcagt caatctgcac agggacacag gtacaccgtt 252960tcttctgact
ccgggaaaca tccagtgtag ccgaaactgt cccagcccag tgaggagccc 253020aggatgttcc
tgaaggctgc ggtgctgacc ctggccctgg tggccatcac cggtgagtag 253080acactgcacc
tgggaggcag caagaaaagc cagctctaga actggcggac agctcggggt 253140ggccttgtat
ttgcccagca gctcatagga gaacaggcct ttgttctccc tggcacttgt 253200gctccctggg
ttatcccagg gatggggcaa tggtttgggt tatccaaact ccaacattat 253260ccagctcaga
gctgaggcag aggggccagg agagagatga tcctcataaa gttgccttct 253320gctctctctc
tgcccaggca cccgggctga ggtcacttcg gaccaggtgg ccaatgtggt 253380gtgggattac
tttacccagc taagcaacaa tgccaaggag gctgtagaac agtttcagaa 253440gacggatgtc
actcagcagc tcaggtaagt gcgatcagtc tacaaggcga ggcttgaagc 253500ccatagctga
cctcagaggt gggacactgg ctcctggagt tcttctgttc tcactaaagg 253560agtcttgcct
ccctggacct agattgtccc tgtaaacagg aaagctggac ccagggatcc 253620atccctatag
ttccttccta tctgcatgtg ctagagtttg gtaaatagcc aaatcccatc 253680acaaactctt
agcaggaaga ggaaagagac gtgtcctgta aggacatgag gttctgggca 253740aacaggggaa
ggagggctgg tattttgggg gacccactga gcacatgcaa ggacatcaga 253800ccctgtgcca
ctggaagaca tgtgttgcac aatgtgaccc tgggagggga gtgatgccaa 253860agtccagccc
cattctttat ccacaggtaa ggaaagcaaa cttctcaagt cacatggtgg 253920gcagataagg
atgcagaggc tcagcagaag ccttgcagat aaaactccaa agtcaaacta 253980atcctaggag
atttcctgaa agcatgacct accccagggg agggtcaaag ggacaagacg 254040gaggtctctg
ttcccatgga cacactcctg acctaagcag gtgtatagag ctgagtgttc 254100tacaagcgta
tctaatggtg cttccttgtc tccatccttt ccctgaagta ccctcttcca 254160ggacaaactt
ggggatgcta gtacgtatgc tgatggggtg cacaacaagc tggtgccctt 254220tgtcgtacag
ctgagtgggc atctagccca ggaaactgag agggtgaagg aagagatcaa 254280gaaggagctg
gaggacctac gtgaccgcat gatgccccat gccaacaaag taacccagac 254340gttcggggag
aacatgcaga agttgcagga gcacctgaag ccctatgccg tggacctgca 254400agatcagatc
aacacacaga cccaggaaat gaagctccag ctgaccccat acatccagcg 254460catgcagacc
acgatcaagg agaatgtgga caacctgcac acctcgatga tgccccttgc 254520caccaactta
aaggacaagt ttaacaggaa tatggaagag ctcaaggggc acctaacccc 254580ccgtgccaac
gagctgaagg ccacgatcga ccagaacctg gaggatctgc gccgcagcct 254640ggcccctctg
acggtgggcg tgcaggagaa actcaaccat cagatggagg gcctggcctt 254700ccagatgaag
aagaacgcgg aggagctcca gaccaaggtc tccgcaaaaa tcgaccagct 254760gcagaagaat
ctggccccgc tggtggaaga cgtgcagagc aaggtgaagg gcaacacgga 254820agggctgcag
aagtctctgg aagacctgaa caggcagctg gagcagcagg tggaggagtt 254880ccgacgcact
gtggagccca tgggagagat gttcaacaag gctctggtgc agcagctgga 254940acagttcaga
cagcagctgg gtcccaattc gggggaggtg gaaagccact tgagcttcct 255000ggagaagagc
ctgagggaga aggtcaactc ctttatgagc accctggaaa aaaaggggag 255060cccagaccag
cctcaagccc tccccctccc ggagcaggcc caggagcagg ctcaggagca 255120ggctcaggag
caggtgcagc ccaaacctct ggagagctga gctgtccctg gtgccctcag 255180cccatcacag
cagcagacac ctgtcctgcc ccaccacctg tctgtcactc tgtccccagg 255240cacttcttgt
accagcttga ggacacatgt cctgtgggag gtgaagccac atctcgctac 255300tcaataaagc
aactgagaaa ttagccccat cgggttgccc tgtgattcct tgggggctgg 255360cctgacgtag
ggaggaaatc aaggcatctg gctggggaca tgggggtgag gggtggggcc 255420ggtaatgagc
cttcgggtgg gtcaggggtt ggtgtgctag agaggagaat gcagaaaaga 255480cgccagtcta
tcagaaaaca aaacacgcat cccgttcaca gcctgcagaa aacaaaacac 255540acatcccgtt
cacagcctgc aaacagttat caaacgccct tgaggttcca gtcaagattc 255600tgagcactag
tcaaaacagc ctttgtggca ttgtgtgcct gaagaccggg cttggtgttg 255660acagggacac
ctggagggca gcaagaccca gtccctgacc ttgaagagtt tactgcacgg 255720caagtccctt
cttgaacatg cctgtgcctt tgaacttatt tatacaaaag taagccactc 255780tgtcccactg
taaagtactc atgtttgccc cggagttttc tccacctatg gataaatctg 255840ttgactccag
agctgtataa tagatgccac gggatatgaa cgagccttgg cagccaaggt 255900ggaacaggct
ttgcccagga gcctcctgat gggtggcttg cctgtctatg acaaagctgg 255960tggtcgctgg
ggcaaagaaa tgaacccatc agaggacccc agtggtttta tggggacagc 256020cagccacagg
aggctgcagt ctctggaatg aattttccct gcccttggag acttagagcc 256080tccctaagga
gggaatctca gagtagagta gttcagggat tccttccaaa agatttcaca 256140tactggctgt
agcctctgcc tcaggtctgc aagtcaaacc cctctgcctc agaatgggta 256200aagttcccct
gggatggact ggaacatgct gtgggtggtc ccagctgctc tggccttctc 256260cctcccttcc
aaggcgtcct ctgtgtgtca taagcccaga cctgggtttg catcctagtt 256320tcctgatact
tctactgggt gatttggagc aggtaacaaa acctgttttg gaaaggaaaa 256380atgaggaacc
ttgggccaga gttattcaga aggtctgatg gtgccaagca cttaatataa 256440ccatcaaggc
aatgtaaata ctaaatgtgt gtgtgtgtgt gtgtgtgtgt gtgtgcgcgc 256500gagcacacgc
gctcacagga tcacgcgcgc gctgtgctgc tctaatgtag cagacaccta 256560ggaaatgtcc
tcctctgctc acatctccag accccagatc caggccacca aatgctttga 256620gtctccccag
cccctgctaa cctcagctac atgggcccaa ctgtcacagc tacttacact 256680tactaccccg
agcagggaag acccaggtga ccacatccta ctagggaaga cccaggtgac 256740caggggacca
cagtcgtcaa ggatgcatgg cagcaggagt ctggctgaat ggctttaaga 256800aatgcttgct
tagagaacca gaggcactac aaggaggcag gacaagggct ggttggtgtc 256860ctgagctgtt
ctggaagctt ctggtagatc agttaggtga gctctgtctc tcaaagcctc 256920tgagtctccc
agtctcttgt tcatagtgca aatcccgagt gggacccctg agttctttcc 256980tgctgtcttc
aggactgtta aacacatctc ccaggggcct gccttactcc tggtttctct 257040gaatgagggt
atacttgctt actttctctt gagccaggat gtcactccta accttcagtc 257100ttttaggtca
cagcttccag gtcacagcat ttgcttttgg ctgctgtaat agactgggtg 257160ttcctgtgaa
cacactgtgg tgcatgcatg tgtgcgtgcg tgcgtgcgtg cgtgcgtgcg 257220tgcgtgtgtg
tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtatg tatctgggtg 257280gatgagtgca
tgtataggtc agaggataac cctcaagaaa accatttgct tcctttggga 257340cagggtctct
tattagcctg gagctcacca attagggtag acaggctgaa cagtgagaga 257400caaggaccca
cttgtccacg cctccctgaa atgaatgtat tccaaccatc aatgtaaagt 257460taggtatggt
tgcacatgcc tttaattcca gcactcagaa gacagaagca agtagatcac 257520tatgagttca
aagccagcct ggcctacatg gggaattcca ggctagccag ggctatataa 257580tgagacctta
tcacaaatga aaacaaataa acaaacaaaa gagactgcgt tagattggtt 257640tattttacct
cctattgctg cggttctgag gttttgtctc ttccatggtt aaacaatttt 257700atttgcagtt
acttttgagt tctgagctca ttgccattaa gtaataacac ataaataaac 257760catctgtgac
ccctaggtct tttcaaatgt cctatgaaga aaacttccct caagattcag 257820ctggctcaca
gccagaaatg ataatgaagg acttttgcaa cttaatcctc aacccagtac 257880caagtatccc
taccctctac cagtagatgg gccccagccc caggacaggt agaaaatgac 257940ccagaaacca
cagtcagtgc aaagagacac actagtcaaa ttgagaagag agcaccagct 258000tagaggagaa
ctgagagaca ctggacttaa gggaggtcag agagaagcac agagcactct 258060gctgccacag
ccctgcagtt cctgtcatgg acaggtcctt ctgagagtgc cagaggagaa 258120aacaactgca
tccaggaggt gacagctcac actcactcag aggcaggtag gtctctgtga 258180gttcaaagtc
agcctggtct atagagtgag atccaggaca gccagaacta tactgagaaa 258240ccctgcttcc
cccacccccc acccaccaaa aaaaaaaaaa aaaggaaaaa gaaaaagaaa 258300acaatcattg
caaagattca atttaggcct aaatcttata atatcttcct ttaactttaa 258360aactacattt
acttatgtgt gcgaggacat gtgtgtatgt gtgtgcatat aatccatgaa 258420cctctcccag
acttgccact agtggtctat aaggattgtg tatggtttga atgtatacaa 258480ataacctttt
aatacctcta tgcattgatt tgacccaaag aaactctaat gagtttcaat 258540tactcccgca
tgctttagaa gcttcaagta ttagatgaaa tagaacaacc gtggggagtt 258600aaggttcgat
tacattgcta ggtctttttt ttttttttgt ttccaacaaa acattatctg 258660tgttcattta
gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga 258720gattaggagg
ggggtctttg ggagaggatg aggtctgtaa aacaggattg gaattctcac 258780agaaggatca
cggaaggatc cccatggaac gttcgccttg cttcaaatgt cagacatagc 258840tagacagcgc
catctatgga tcagagggtg gccttcacca gatacttgat ggctggaacc 258900tgggtgtggt
ataggagtat agaagagaga gcaagagaga gcgagagaag agagagagag 258960agagagagag
agagagagag agagagagag agagagagag agagagtgag agagagagag 259020cgagagagcg
agagagtgag agagagaaag cgagagagcg agagagtgag agagagaaag 259080cgagagagcg
agagagagat gtttttatga gtctccatgc ctatagtact atggtatttt 259140gctagaacag
tctgagtagg tttctgacaa cagctgccca gcttctgaaa gttccttgct 259200ttggctgaag
aatgtccttt gaggaagttt tgtttctggg gttttgtttt gttttgtttt 259260gttttgtttt
gttttgtttt gttttgaaaa aagagtctca tgtatcttgg gctggtctca 259320catttgaaat
gtaccaaaga tcaccttgaa cttctgatcc tcctgactcc atgtcccaaa 259380cgatagaact
gcagatgtgc actaccaccc ctggccctct gggcagtttt atttttaatt 259440ttcttattta
tacatttatt tgtttgtgca ttgattgatt gattgattgt gtgtgtgtgt 259500gtgtgtgtgt
gtgtgtgtat ggacacacac atgtgtgagt atgtgcatat gggtatgtat 259560gcatgtgtgc
actccggcta tatgtatgta aaggtcagag gacaactttc gatggtgggt 259620tgggttccct
ccctttacca tgcgggacct gaagattggg ctcaggtaat ccaacctgac 259680cgcaagcgcc
tttacttact gagggaattg acctgtgact cctggtacag atgccaaaca 259740gcagcctctt
acagcatggt gtggtggaag aggcctgcaa tcctaggatt aggaggatga 259800agcagtttgg
gggccatact ggacttcaca gagagaatcc gtaaggaagg taggaaggaa 259860ggaataaagg
gaggaaggga ggaagagaga ggagggatga agggaaggaa gaaggaaagg 259920gaagacaaga
agaaaagaag gacaggggga agagggacaa aggcagcata gctctccacc 259980agtctggttt
atggtgacgg cagctagagt cctctcctgc tttccctgat gtcttttttt 260040ctaagctgtg
tcctccaact ttgcaggatt tttaaaaacc tagtccaatc agttaaattc 260100tggctcacat
cttccagcac agaggtccat tccagcagat ggctcagcaa gtaaaggcgc 260160ttgcggtcag
gttagattac ctgagcccaa tcttcaggtc ccgcatggta aagggaggga 260220acccaaccta
cactcgaaag ttgtcctctg acctttccat ccatacaggg gtccaccaag 260280taagagcctt
acccgacaca ccttctcatc ccttcttagg aagccctatg tgccttggcc 260340tttggaagcc
atagtctttg ccctgcctgc acaagtcatg ctggcctgtc tgcaggaggc 260400ttagtcctta
gaagattggt tgctcctcaa ggaaagagcc accccctttg tgctaagaca 260460ctgagtggac
ctagtctccc atagcccagt ttatcccagg tcatctctag cagctaagat 260520actggacaaa
ttgaaagtga catctgtctg ggcttaagtg accagtctca tctgtcctgt 260580tcagggaccc
tctgacagct gagttcaagg ggaagagggg agtcctgata tgggtctaca 260640aacctctgta
tttttttaag agagagagag agagagacag acagacagac agacagacag 260700acagacagac
agagactaga acaggttagc cctgaccttg cctgtagcta agggtgactc 260760tggcatgctg
atacccctcc tatcccctac ctcccacatt ctgagatttt ttgagccatc 260820atgcctggct
tatccagtgc tggagactga actcagagtc ttgtgtatgc ttgtcaatca 260880ctcgactggc
tgagccacat tcccagctct ggtattctat tttggatgtg tgatggtctg 260940gctccatagt
ccagaacagc cttgaactcc tgaccctagg gtcagcccta aattctggga 261000ttacaaatgt
atgtcaccat tcccagatat ttatgaaaat atctcccaaa gattttaagt 261060taatgatatg
ttgacaaata cacgatacat acgtctattg ctacagcttg gatttgagct 261120gtccctcaaa
ggcccatgtg gtaagatgtg accactagcc cctggcactg ttgggaggtg 261180gtggaatctt
taggtgctgg gacccagtgg gagaaaagtc actggaggta tcatggtcct 261240tgaaagggat
acaggtgcct ggtctctctg ctctccctcc ttgcttccct gtcagcacaa 261300ggtaaacaac
ttccttcaaa cacatgttct cgccatgatg cccttcttga cataggtcca 261360aaagtaacag
gctaactggc cttggaatct ctgagaccct tagagaaaaa taaactgttt 261420ttttttccac
attaggttga tttctcgtgg gtatttgtaa tggtgacaga aaactgatga 261480acacagagac
tgtatttgaa tatgataacc caaggcagtg tgtagttaag atagctggac 261540ctcagcaccc
atcagtcaga ggcactgtta accatgctgg gcaatgaaca ggagaccctg 261600aaaaatggca
ggaaggagat ttgaaatcca gatggcttca acaggccttt ggagagtaca 261660gagggaggag
gggttgaaga agggaaaatg aagtccacga gaaggctaac cacccatctg 261720agaccgccat
ggagaaaggc ccagtagcaa ggcctgtgag gcgcttctga caaacaatta 261780tccgcgttgg
gtcattgtgt catcctttta acagactgtg acctcagtgg tgaagagggg 261840aagaaaaggc
agttgggtcc ctaggggtgg acctgggatt tgaacacgtg atctacagac 261900tggaaacttt
tctgttagct gccaagctgt gatggaagct gtgatggtga aatgttcata 261960gatgagcagg
gatactcttg tacaaggagc aggcttgggt cctgtctcat catgctccaa 262020gcccagcatc
aggctcttac cggagaaagg aggccggatg ctaaaggaac cgctcccagg 262080actcctgtga
ggaagaaggg gcttccgttt ttattttata aatttctaaa acgttggaat 262140ttttctcctg
gttttctttc tttctttatt tacatccaaa cgctgtccct tctcccagtc 262200ctccattgaa
gtgttcctcc cccacatccc tcccctttgc ctctgagaag gttgccccct 262260cgcaggtatc
ccccaaccct ggtgcatcaa gtctttgtag gattaagtgc atcctgtccc 262320actgaggcga
gacaaggcag tccactgata catgtgtctc tgtgtgtgta tgtgggggtg 262380gtggtggtgg
tggtgtttgg accagcccgt gcttgctctt tggttggtgg ctcagtcact 262440aggatcctca
actctgcctc ctgagtactg ggaataaaaa tgtgagccgc caccaccctg 262500caaacattag
aattttaaaa aagatttatt tttattttta ttttctgggc atgattgttt 262560tacctgcagg
tatgtgtgtg tatcatgtgc atgcttggtg cccacagaga tgtgaagaag 262620gcatccaata
ccctgaactg gagttacaga cagttgtgag gcactgcgtg agtgctggga 262680actgagcacg
ggtcctctga aagagcagca agggttttaa cctttgagcc atccttccag 262740tcccagacat
tggaattatt tttaaagatt tatttttgtt ttatatgtat gagtgttttg 262800cctgcaccac
atgcatgccc agtgccttca gaggtcagaa gaggatgcca gatttccttg 262860aaatgaagtt
acagacactt gtaagtcacc atgtgggtat tgagaacaaa gcccaggtct 262920tcagcaagtg
ctggtaacca ctgagccatc cttccagccc aagatctggg atataaaaat 262980gaacttttat
actacttttt tcttcccctt ccttccttcc ttcctttctt ccttccttca 263040taccatacag
agatatataa gttccggact ctggaatacc tcttaaatat gtccctctgg 263100gtgagtgtat
atacatgtgg gtgcgcgctt acatgcctcg catgctctct tgggctcttt 263160tcacagaatg
ccctgtaacc agggtaaggt ggcactctct ttgagtaatg ataagaattg 263220gcccgctttc
taatttccat atgcggctgt ccaaaacgaa aaaaggagtc gaccccttaa 263280gagctggaga
ggccctcttg taaatacacg atcaaggtgg tccctcactg aataggttac 263340ttgggcgagt
gggtcttcac atttcgtggt ctaaaaccac agcgctaacc tataaaatgc 263400gtgtccggca
cgaaatacaa ttgcactccc gagaaaacac ccgcgggggg ttacgattga 263460atatctattg
agagcacaac actctccccc tatttcggag aaactattgg gccctaccca 263520tgttttttat
aaactctcaa atgggcccta cccaaacaac atatcgcggt tttttttgtt 263580aaatcacaac
gcaaagaggg gtcgaaaata aatccctcgg cgggacctcg acacacaatc 263640tttcaccata
tgagcgcgcc cacaacactg atcacatata tcgctgctcg cggagaaggt 263700accgacctct
catctctttg gggtccgtcc acacaaaaga aaag 2637447366PRTHomo
sapiens 7Met Ala Ser Met Ala Ala Val Leu Thr Trp Ala Leu Ala Leu Leu Ser1
5 10 15Ala Phe Ser Ala
Thr Gln Ala Arg Lys Gly Phe Trp Asp Tyr Phe Ser 20
25 30Gln Thr Ser Gly Asp Lys Gly Arg Val Glu Gln
Ile His Gln Gln Lys 35 40 45Met
Ala Arg Glu Pro Ala Thr Leu Lys Asp Ser Leu Glu Gln Asp Leu 50
55 60Asn Asn Met Asn Lys Phe Leu Glu Lys Leu
Arg Pro Leu Ser Gly Ser65 70 75
80Glu Ala Pro Arg Leu Pro Gln Asp Pro Val Gly Met Arg Arg Gln
Leu 85 90 95Gln Glu Glu
Leu Glu Glu Val Lys Ala Arg Leu Gln Pro Tyr Met Ala 100
105 110Glu Ala His Glu Leu Val Gly Trp Asn Leu
Glu Gly Leu Arg Gln Gln 115 120
125Leu Lys Pro Tyr Thr Met Asp Leu Met Glu Gln Val Ala Leu Arg Val 130
135 140Gln Glu Leu Gln Glu Gln Leu Arg
Val Val Gly Glu Asp Thr Lys Ala145 150
155 160Gln Leu Leu Gly Gly Val Asp Glu Ala Trp Ala Leu
Leu Gln Gly Leu 165 170
175Gln Ser Arg Val Val His His Thr Gly Arg Phe Lys Glu Leu Phe His
180 185 190Pro Tyr Ala Glu Ser Leu
Val Ser Gly Ile Gly Arg His Val Gln Glu 195 200
205Leu His Arg Ser Val Ala Pro His Ala Pro Ala Ser Pro Ala
Arg Leu 210 215 220Ser Arg Cys Val Gln
Val Leu Ser Arg Lys Leu Thr Leu Lys Ala Lys225 230
235 240Ala Leu His Ala Arg Ile Gln Gln Asn Leu
Asp Gln Leu Arg Glu Glu 245 250
255Leu Ser Arg Ala Phe Ala Gly Thr Gly Thr Glu Glu Gly Ala Gly Pro
260 265 270Asp Pro Gln Met Leu
Ser Glu Glu Val Arg Gln Arg Leu Gln Ala Phe 275
280 285Arg Gln Asp Thr Tyr Leu Gln Ile Ala Ala Phe Thr
Arg Ala Ile Asp 290 295 300Gln Glu Thr
Glu Glu Val Gln Gln Gln Leu Ala Pro Pro Pro Pro Gly305
310 315 320His Ser Ala Phe Ala Pro Glu
Phe Gln Gln Thr Asp Ser Gly Lys Val 325
330 335Leu Ser Lys Leu Gln Ala Arg Leu Asp Asp Leu Trp
Glu Asp Ile Thr 340 345 350His
Ser Leu His Asp Gln Gly His Ser His Leu Gly Asp Pro 355
360 365821DNAMus musculus 8gaggatgtgg agctctaccg c
21922DNAMus musculus
9ctgtgtgcgc agagagtcta cg
221020DNAHomo sapiens 10cccgctgcag tccccagaat
201122DNAHomo sapiens 11cagggtcgag ggctcttgtc ct
221234DNAMus musculus
12tgactctaga tacccttggt cccatgttcc agat
341334DNAMus musculus 13cattgaattc gacaagagaa agacggggct caag
341439DNAMus musculus 14tatgactgcg gccgccacca
atcccacatc taagcatct 391521DNAMus musculus
15gctcggttct gggcacagag a
211623DNAMus musculus 16cttgaggatg ggcatcagct gta
231723DNAMus musculus 17gctcactaac agcgctcttg cct
231822DNAMus musculus
18acagttggag caaaggcgtg at
221922DNAMus musculus 19cttgctcgaa gctgcctttc ag
222025DNAHomo sapiens 20gattgattca agatgcattt aggac
252122DNAHomo sapiens
21ccccaggaac tggagcgaaa tt
222220DNAHomo sapiens and Mus musculus 22gcgcgtggtg ggrgaagaca
202320DNAHomo sapiens and Mus
musculus 23tcgcgcagct ggtccaggtt
202424DNAHomo sapiens 24tgctcacctg ggctctggct cttc
242527DNAHomo sapiens 25ccagaagcct ttccgtgcct
gggcggc 272630DNAHomo sapiens
26tggtgcacca cgaggctctg cagcagtccc
302727DNAHomo sapiens 27aggtggccct gcgagtgcag gagctgc
272831DNAHomo sapiens 28atgacgtggc agacgtaatg
gcaagcatgg c 312927DNAHomo sapiens
29cgcgccgagg ataatggcaa gcatggc
273030DNAHomo sapiens 30gcctccctcc acctgtcttc tcagagcagt
303131DNAHomo sapiens 31atgacgtggc agacgaaaac
gctgtggaga g 313227DNAHomo sapiens
32cgcgccgagg caaaacgctg tggagag
273323DNAHomo sapiens 33gcctttccgt gcctgggtgg cct
233429DNAHomo sapiens 34atgacgtggc agacgtggtg
ggggaagac 293525DNAHomo sapiens
35cgcgccgagg atggtggggg aagac
253624DNAHomo sapiens 36aggagctgca ggagcagttg cgct
243721DNApPNT2T vector 37ctttttgtca agaccgacct g
213821DNApPNT2T vector
38aatatcacgg gtagccaacg c
213923DNAHomo sapiens 39atgacctgtg ggaagacatc act
234023DNAHomo sapiens 40agccagaagt gactagagcc aaa
234123DNAHomo sapiens
41agtccccaga atcaaaggat gat
234222DNAHomo sapiens 42atcgtgtagg gcttcagttg ct
224324DNAHomo sapiens 43cctgtcttct cagagcaggt aatg
244423DNAHomo sapiens
44agccatcttc tgctgatgga tct
234523DNAHomo sapiens 45aagacaccct agcctccttg act
234621DNAHomo sapiens 46acagaggttg aggcagcaga g
214723DNAHomo sapiens
47gtagtgaaaa tcaggggcct tct
234823DNAHomo sapiens 48atgcataaac ccaaagggaa aat
23
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