Patent application title: METHODS OF IDENTIFYING PATIENTS LIKELY TO BENEFIT FROM TREATMENT WITH A TELOMERASE INHIBITOR
Inventors:
IPC8 Class: AC12Q16886FI
USPC Class:
1 1
Class name:
Publication date: 2020-02-27
Patent application number: 20200063214
Abstract:
This disclosure provides methods of identifying or selecting a patient
most likely to benefit from treatment with a telomerase inhibitor, such
as e.g. imetelstat, by testing a patient for: a lack of a mutation in
each of JAK2, CALR, and MPL; and/or a high-molecular risk (HMR), based on
the presence of a mutation in at least one of the following genes: ASXL1,
EZH2, SRSF2, and IDH1/2. The patient may be suffering from myelofibrosis.
The disclosure also provides methods of treating myelofibrosis, which
include identifying such patients.Claims:
1. A method of treating a patient that has myelofibrosis with a
telomerase inhibitor, the method comprising administering the telomerase
inhibitor to the patient if the patient is determined to have a triple
negative status, wherein the triple negative status comprises an absence
of a mutation in each of the Janus kinase 2 (JAK2), calreticulin (CALR),
and thrombopoietin receptor (MPL) genes.
2. The method of claim 1, wherein the myelofibrosis is selected from primary myelofibrosis or myelofibrosis that develops post-polycythemia vera (post-PV MF) or myelofibrosis that develops post essential thrombocythemia (post-ET MF).
3. The method of claim 1, wherein the patient has not previously received JAK-inhibitor therapy.
4. The method of claim 1, wherein the patient: has previously received JAK-inhibitor therapy and is relapsed; has previously received JAK-inhibitor therapy and is refractory; or has previously received JAK-inhibitor therapy and has discontinued JAK-inhibitor therapy due to treatment-related to toxicities or intolerance.
5. The method of claim 1, wherein the telomerase inhibitor is imetelstat.
6. The method of claim 5, wherein the imetelstat is imetelstat sodium.
7. The method of claim 5, wherein the telomerase inhibitor is imetelstat and is administered for 1, 2, 3, 4, 5, 6, 7, 8 or more than 8 dosage cycles, each cycle comprising: intravenous administration of about 7-10 mg/kg imetelstat once every three weeks; intravenous administration of about 7-10 mg/kg imetelstat once weekly for three weeks; intravenous administration of about 2.5-10 mg/kg imetelstat once every three weeks; or intravenous administration of about 0.5-9.4 mg/kg imetelstat once every three weeks.
8. The method of claim 7, wherein each dosage cycle comprises intravenous administration of about 7-10 mg/kg imetelstat once every three weeks.
9. The method of claim 8, wherein each dosage cycle comprises intravenous administration of about 9.4 mg/kg imetelstat once every three weeks.
10. The method of claim 1, further comprising determining average relative telomere length by analyzing the relative length of telomeric nucleic acids in target cells present in a biological sample from the patient.
11. The method of claim 10, further comprising selecting a patient identified as having an average relative telomere length in target cells present in a biological sample from the patient determined to be in the 50th percentile or less of a relative telomere length range determined from one or more known standards.
12. The method of claim 1, further comprising screening a patient to determine if the patient has a high-molecular risk (HMR), wherein having HMR comprises the presence of a mutation in at least one gene selected from the group consisting of ASXL1, EZH2, SRSF2 and IDH1/2.
13. The method of claim 1, further comprising assessing hTERT expression level in a biological sample obtained from the patient after administration of the telomerase inhibitor.
14. The method of claim 13, wherein the hTERT expression level is reduced by 50% or more relative to a baseline hTERT expression level prior to administration of the telomerase inhibitor.
15. The method of claim 14, further comprising altering the dosage of the telomerase inhibitor, the frequency of dosing, or the course of therapy administered to the subject.
16. A method of treating a patient that has myelofibrosis with a telomerase inhibitor, the method comprising administering the telomerase inhibitor to the patient if the patient is determined to have a high-molecular risk (HMR), wherein having HMR comprises the presence of a mutation in at least one gene selected from the group consisting of additional sex combs like 1 (ASXL1), enhancer of zeste homolog 2 (EZH2), serine and arginine rich splicing factor 2 (SRSF2), and isocitrate dehydrogenase 1/2 (IDH1/2).
17. The method of claim 16, wherein the myelofibrosis is selected from primary myelofibrosis or myelofibrosis that develops post-polycythemia vera (post-PV MF) or myelofibrosis that develops post essential thrombocythemia (post-ET MF).
18. The method of claim 16, wherein the patient has not previously received JAK-inhibitor therapy.
19. The method of claim 16, wherein the patient: has previously received JAK-inhibitor therapy and is relapsed; has previously received JAK-inhibitor therapy and is refractory; or has previously received JAK-inhibitor therapy and has discontinued JAK-inhibitor therapy due to treatment-related to toxicities or intolerance.
20. The method of claim 16, wherein the telomerase inhibitor is imetelstat.
21. The method of claim 20, wherein the imetelstat is imetelstat sodium.
22. The method of claim 20, wherein the telomerase inhibitor is imetelstat and is administered for 1, 2, 3, 4, 5, 6, 7, 8 or more than 8 dosage cycles, each cycle comprising: intravenous administration of about 7-10 mg/kg imetelstat once every three weeks; intravenous administration of about 7-10 mg/kg imetelstat once weekly for three weeks; intravenous administration of about 2.5-10 mg/kg imetelstat once every three weeks; or intravenous administration of about 0.5-9.4 mg/kg imetelstat once every three weeks.
23. The method of claim 22, wherein each dosage cycle comprises intravenous administration of about 7-10 mg/kg imetelstat once every three weeks.
24. The method of claim 23, wherein each dosage cycle comprises intravenous administration of about 9.4 mg/kg imetelstat once every three weeks.
25. The method of claim 16, further comprising determining average relative telomere length by analyzing the relative length of telomeric nucleic acids in target cells present in a biological sample from the patient.
26. The method of claim 25, further comprising selecting a patient identified as having an average relative telomere length in target cells present in a biological sample from the patient determined to be in the 50th percentile or less of a relative telomere length range determined from one or more known standards.
27. The method of claim 16, further comprising screening a patient to determine if the patient is triple negative status, wherein the triple negative status comprises an absence of a mutation in each of the genes selected from the group consisting of JAK2, CALR and MPL.
28. The method of claim 16, further comprising assessing hTERT expression level in a biological sample obtained from the patient after administration of the telomerase inhibitor.
29. The method of claim 28, wherein the hTERT expression level is reduced by 50% or more relative to a baseline hTERT expression level prior to administration of the telomerase inhibitor.
30. The method of claim 29, further comprising altering the dosage of the telomerase inhibitor, the frequency of dosing, or the course of therapy administered to the subject.
31. A method of treating a patient that has myelofibrosis with a telomerase inhibitor, the method comprising administering the telomerase inhibitor to the patient if cells present in a biological sample from the patient are determined to have average relative telomere length that is determined to be in the 50th percentile or less of a relative telomere length range determined from one or more known standards.
32. The method of claim 31, wherein the myelofibrosis is selected from primary myelofibrosis or myelofibrosis that develops post-polycythemia vera (post-PV MF) or myelofibrosis that develops post essential thrombocythemia (post-ET MF).
33. The method of claim 31, wherein the patient has not previously received JAK-inhibitor therapy.
34. The method of claim 31, wherein the patient: has previously received JAK-inhibitor therapy and is relapsed; has previously received JAK-inhibitor therapy and is refractory; or has previously received JAK-inhibitor therapy and has discontinued JAK-inhibitor therapy due to treatment-related to toxicities or intolerance.
35. A method of selecting a patient most likely to benefit from treatment with a telomerase inhibitor comprising: testing a patient for triple negative status, wherein the triple negative status comprises an absence of a mutation in each of the JAK2, CALR and MPL genes; and selecting the patient if the patient has triple negative status, wherein the selected patient is most likely to benefit from treatment with a telomerase inhibitor.
36. The method of claim 35, wherein the myelofibrosis is selected from primary myelofibrosis or myelofibrosis that develops post-polycythemia vera (post-PV MF) or myelofibrosis that develops post essential thrombocythemia (post-ET MF).
37. The method of claim 35, wherein the patient has not previously received JAK-inhibitor therapy.
38. The method of any one of claim 35, wherein the patient: has previously received JAK-inhibitor therapy and is relapsed; has previously received JAK-inhibitor therapy and is refractory; or has previously received JAK-inhibitor therapy and has discontinued JAK-inhibitor therapy due to treatment-related to toxicities or intolerance.
39. The method of claim 35, further comprising screening a patient to determine if the patient has a high-molecular risk (HMR), wherein having HAIR comprises the presence of a mutation in at least one gene selected from the group consisting of ASXL1, EZH2, SRSF2 and IDH1/2.
40. The method of claim 35, further comprising administering the telomerase inhibitor to the patient.
41. The method of a claim 35, further comprising obtaining a sample that comprises DNA from the patient.
42. A method of selecting a patient most likely to benefit from treatment with a telomerase inhibitor comprising: testing a patient to determine if the patient has a high molecular risk (HMR), wherein having HMR comprises the presence of a mutation in at least one gene selected from the group consisting of ASXL1, EZH2, SRSF2, and IDH1/2; and selecting the patient if the patient has a high molecular risk (HMR), wherein the selected patient is most likely to benefit from treatment with a telomerase inhibitor.
43. The method of claim 42, wherein the myelofibrosis is selected from primary myelofibrosis or myelofibrosis that develops post-polycythemia vera (post-PV MF) or myelofibrosis that develops post essential thrombocythemia (post-ET MF).
44. The method of claim 42, wherein the patient has not previously received JAK-inhibitor therapy.
45. The method of any one of claim 42, wherein the patient: has previously received JAK-inhibitor therapy and is relapsed; has previously received JAK-inhibitor therapy and is refractory; or has previously received JAK-inhibitor therapy and has discontinued JAK-inhibitor therapy due to treatment-related to toxicities or intolerance.
46. The method of claim 42, further comprising screening a patient to determine if the patient is triple negative status, wherein the triple negative status comprises an absence of a mutation in each of the genes selected from the group consisting of JAK2, CALR and MPL.
47. The method of claim 42, further comprising administering the telomerase inhibitor to the patient.
48. The method of claim 42, further comprising obtaining a sample that comprises DNA from the patient.
49. A method of monitoring therapeutic efficacy in a subject with myelofibrosis (MF), the method comprising: measuring hTERT expression level in a biological sample obtained from the patient after administration of a telomerase inhibitor; and comparing the hTERT expression level in the biological sample to a baseline hTERT expression level prior to administration of the telomerase inhibitor; wherein a 50% or greater reduction in hTERT expression level in the biological sample identifies a subject who has an increased likelihood of benefiting from treatment with the telomerase inhibitor.
50. The method of claim 49, wherein the hTERT expression level measured or assessed is hTERT RNA expression level.
Description:
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] Pursuant to 35 U.S.C. .sctn. 119(e), this application claims the benefit of priority to the filing dates of U.S. Provisional Patent Application Ser. No. 62/712,841 filed on Jul. 31, 2018 and U.S. Provisional Patent Application Ser. No. 62/772,849 filed on Nov. 29, 2018; the disclosures of which application are herein incorporated by reference.
SEQUENCE LISTING
[0002] The instant application contains a Sequence Listing, which has been filed electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy is named Sequence Listing.txt and is 356 KB in size.
FIELD OF THE INVENTION
[0003] The present application relates to methods of identifying a patient most likely to benefit from treatment of a telomerase inhibitor by identifying a patient: lacking a mutation in each of JAK2, CALR, and MPL; and/or having a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2. The invention also relates to methods of treating myelofibrosis in a subject in need thereof (i.e. patient) with a telomerase inhibitor.
INTRODUCTION
[0004] Myelofibrosis (MF) is one of the classical BCR-ABL1-negative chronic myeloproliferative neoplasms (MPNs), characterized by clonal myeloproliferation, dysregulated kinase signaling. Cervantes, Blood, 124(17):2635-2642 (2014). It is also characterized by cytopenias, constitutional symptoms, splenomegaly, and may transform into acute myeloid leukemia. Kuykendall et al., Annals of Hematology, 97: 435-431 (2018). MF is a poor-prognosis Philadelphia chromosome negative myeloproliferative neoplasm, for which the JAK1/JAK2 inhibitor ruxolitinib is currently an approved therapy. Ruxolitinib, a Janus kinase (JAK)-1 and JAK-2 inhibitor, is the first-in-class drug to be licensed in the United States for the treatment of high- and intermediate-risk myelofibrosis (MF). Pardanani, et al. Blood Cancer J.; 4(12): e268 (2014). Several other JAK inhibitors are in development with some currently undergoing phase-3 clinical trial testing. Id. Other treatment options for MF include allo-SCT, hydroxyurea, interferon, lenalidomide (Revlimid.RTM.) and thalidomide. Currently, there are ongoing clinical trials in MF to evaluate selective JAK inhibitors, histone deacetylase/DNA methyltransferase inhibitors, PI3K-inhibitors, Hedgehog/mammalian target of rapamycin (MTOR) inhibitors, anti-fibrotic agents, immunomodulators, monoclonal antibodies, and immune checkpoint inhibitors. Shreenivas, et al., Expert Opin Emerg Drugs, 23(1):37-49 (2018).
[0005] Other MPNs include essential thrombocythemia (ET) and polycythemia vera (PV). Cervantes (infra). MF may appear de novo (primary MF [PMF]) or following previous ET or PV (post-ET or post-PVMF). Id. According to Cervantes, MF is a clonal proliferation of a pluripotent hematopoietic stem cell in which the abnormal cell population releases several cytokines and growth factors in the bone marrow that lead to marrow fibrosis and stroma changes and colonizes extramedullary organs such as the spleen and liver. Id. Myelofibrosis has been associated with mutations in the Janus kinase (JAK) 2 gene (such as a V617F mutation), mutations in thrombopoietin receptor gene (MPL) and mutations in the calreticulin gene (CALR). Id. It mainly affects the elderly, and, according to Cervantes, "[a]t present, there is no curative treatment other than allogeneic hemopoietic stem cell transplantation (allo-SCT), which can be applied to a minority of patients." Id.
[0006] In fact, according to Langabeer, "[t]he majority of patients with classical myeloproliferative neoplasms (MPN) of polycythemia vera, essential thrombocythemia, and primary myelofibrosis harbor distinct disease driving mutations within the JAK2, CALR, or MPL genes." Langabeer, JAK-STAT, 5: e1248011 (2016). These mutations are so-called driver mutations. Exemplary driver mutations include JAK2 V617F, mutations with JAK2 exon 12, MPL exon 10, and CALR exon 9. Id.
[0007] According to Spiegel, in myelofibrosis (MF), driver mutations in JAK2, MPL, or CALR impact survival and progression to blast phase, with the greatest risk conferred by triple-negative status (i.e. nonmutated JAK2, MPL, and CALR). Spiegel et al., Blood Adv., 1(20):1729-1738 (2017). In fact, the absence of JAK2/MPL/CALR mutations (that is, triple negative) is associated with the most unfavorable outcome. Pardanani, et al. Blood Cancer J.; 4(12): e268 (2014); see also Tefferi et al., Blood, 124(16):2507-13 (2014). Furthermore, mutations in high-molecular risk (HAIR) genes, such as ASXL1, EZH2, IDH1/2, and SRSF2 have also been associated with inferior prognosis. Spiegel et al. The presence of increasing number of prognostically detrimental/"high molecular risk" mutations (that is, ASXL1, EZH2, SRSF2, and/or IDH-1/2 genes) conferred a progressively worse survival outcome, independent of traditional risk factors. Guglielmelli et al., Leukemia, 28(9):1804-10 (2014).
[0008] Driver mutations in JAK2, MPL, or CALR, either alone or in combination with subclonal mutations in genes, such as ASXL1, have been associated with differences in overall survival (OS). Spiegel et al. Triple-negative patients, who lack canonical mutations in JAK2,MPL, or CALR, have an increased risk of leukemic transformation as well as shortened OS. Spiegel observed that for patients suffering from myelofibrosis that were treated with ruxolitinib or momelotinib (JAK 1/2 inhibitors), these mutations were associated with a shorter time to treatment failure. Id. Similarly, "[c]omparing the clinical characteristics of JAK2-positive, CALR-positive, MPL-positive, and TN MF patients, those with CALR mutations had significantly lower hemoglobin (mean, 8.6 vs 10.7 g/dL; P 5.001) and white blood cell counts (mean, 11.0 vs 25 g/dL; P 5.033), trends that have been reported in other MPN cohorts." Patel et al., Blood; 126(6):790-797 (2015). Patel et al. observed that patients treated with ruxolitinib, harboring .gtoreq.3 mutations exhibited inverse correlation with spleen response and time to treatment discontinuation. Driver mutations or triple negative (JAK2, MPL, CALR) status are found in myelofibrosis patient who discontinue treatment with JAK inhibitors. See e.g. Kuykendall et al.
SUMMARY
[0009] The invention provides methods of identifying or selecting a patient most likely to benefit from treatment with a telomerase inhibitor, such as e.g. imetelstat, by testing a patient for: a lack of a mutation in each of Janus kinase 2 (JAK2), calreticulin (CALR), and thrombopoietin receptor (MPL) genes; and/or a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: additional sex combs like 1 (ASXL1), enhancer of zeste homolog 2 (EZH2), serine and arginine rich splicing factor 2 (SRSF2), and isocitrate dehydrogenase 1/2 (IDH1/2). The patient in need of treatment may be suffering from myelofibrosis. The invention also provides methods of treating myelofibrosis in a patient in need of such treatment, which include the step of identifying such a patient.
[0010] One embodiment of the invention is a method of identifying a myelofibrosis patient most likely to benefit from treatment with a telomerase inhibitor comprising: (a) testing a patient for the following: (i) triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL genes, and/or (ii) a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2; and (b) selecting the patient if the patient has: (i) triple negative status, based on the lack of mutation in each of JAK2, CALR, and MPL genes, and/or (ii) high molecular risk (HMR) based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2, wherein the selected patient is most likely to benefit from treatment with a telomerase inhibitor.
[0011] An alternate embodiment of the invention is a method of identifying a patient most likely to benefit from treatment with a telomerase inhibitor comprising: (a) testing a patient for: triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL genes; and (b) selecting the patient if the patient has: triple negative status, wherein the selected patient is most likely to benefit from treatment with a telomerase inhibitor. An alternate embodiment of the invention is a method of identifying a patient most likely to benefit from treatment with a telomerase inhibitor comprising (a) testing the patient for high molecular risk (HMR) based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2 and (b) selecting a patient that is high molecular risk (HMR) based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2. The invention further provides for methods of treating myelofibrosis in a patient that is triple negative and/or HMR with a telomerase inhibitor, such as e.g. imetelstat.
[0012] Another embodiment of the invention is a method of identifying a patient that has myelofibrosis most likely to benefit from treatment with a telomerase inhibitor comprising: (a) obtaining a DNA sample from a patient; (b) testing the DNA sample from such patient for (i) triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL genes; and/or (ii) a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2; and (c) selecting the patient if the patient has (i) triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL genes, and/or (ii) a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2, wherein the selected patient is most likely to benefit from treatment with a telomerase inhibitor. In certain embodiments of the method, the DNA sample is obtained from bone marrow, peripheral blood, or both.
[0013] The DNA sample may be obtained by first obtaining a bone marrow sample, a peripheral blood sample, or both and then isolating the DNA from the bone marrow sample, the peripheral blood sample, or both. In one embodiment, the step of obtaining a DNA sample from a patient comprises: obtaining a bone marrow sample from the patient, isolating cells from the bone marrow sample, and extracting DNA from the isolated cells. In another embodiment, the step of obtaining a DNA sample from a patient comprises: obtaining a peripheral blood sample from the patient; isolating cells from the peripheral blood sample (e.g. granulocytes); and extracting DNA from the isolated cells.
[0014] Yet another embodiment of the invention is a method of identifying a patient that has myelofibrosis most likely to benefit from treatment with a telomerase inhibitor comprising testing a patient for: (a) triple negative status, based on the absence of any mutation in JAK2, CALR, and MPL genes; (b) a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2; or (c) both; wherein the presence of (a), (b) or (c) is indicative of a patient most likely to benefit from treatment with a telomerase inhibitor.
[0015] In any of these methods, the patient may be suffering from myelofibrosis. The myelofibrosis may be: primary myelofibrosis; myelofibrosis that develops post-polycythemia vera (post-PV MF); or myelofibrosis that develops post essential thrombocythemia (post-ET MF). In certain embodiments, the patient has not previously received JAK-inhibitor therapy. In other embodiments, the patient has previously received JAK-inhibitor therapy and has "failed" JAK-inhibitor therapy (i.e., the disease was resistant or the patient was refractory to the therapy or although initially responsive to treatment, the disease has relapsed). In other embodiments, the patient has received JAK-inhibitor therapy and has discontinued JAK-inhibitor therapy due to treatment-related toxicities or intolerance.
[0016] The methods may also include the step of administering the telomerase inhibitor once such a patient has been identified. In certain embodiments, the telomerase inhibitor is imetelstat or a pharmaceutically acceptable salt thereof. In other embodiments, the imetelstat is imetelstat sodium.
[0017] When imetelstat is used to treat patients identified by these methods, imetelstat is administered for 1, 2, 3, 4, 5, 6, 7, 8, or more than 8 dosage cycles, each cycle comprising: intravenous administration of about 7-10 mg/kg imetelstat once every three weeks; intravenous administration of about 7-10 mg/kg imetelstat once weekly for three weeks; intravenous administration of about 2.5-10 mg/kg imetelstat once every three weeks; or intravenous administration of about 0.5-9.4 mg/kg imetelstat once every three weeks. In one embodiment, each dosage cycle comprises intravenous administration of about 7-10 mg/kg imetelstat once every three weeks. In another embodiment, each dosage cycle comprises intravenous administration of about 9.4 mg/kg imetelstat once every three weeks.
[0018] When imetelstat sodium is used to treat patients identified by these methods, imetelstat sodium is administered for 1, 2, 3, 4, 5, 6, 7, 8, or more than 8 dosage cycles, each cycle comprising: intravenous administration of about 7-10 mg/kg imetelstat sodium once every three weeks; intravenous administration of about 7-10 mg/kg imetelstat sodium once weekly for three weeks; intravenous administration of about 2.5-10 mg/kg imetelstat sodium once every three weeks; or intravenous administration of about 0.5-9.4 mg/kg imetelstat sodium once every three weeks. In one embodiment, each dosage cycle comprises intravenous administration of about 7-10 mg/kg imetelstat sodium once every three weeks. In another embodiment, each dosage cycle comprises intravenous administration of about 9.4 mg/kg imetelstat sodium once every three weeks.
[0019] Another embodiment of the invention is a method of treating a patient that has myelofibrosis with a telomerase inhibitor, such as imetelstat or imetelstat sodium, comprising:
[0020] (i) screening the patient to determine if such patient is: triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL, and/or a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2; and
[0021] (ii) administering the telomerase inhibitor to the patient if such patient is triple negative status, based on the absence of a mutation in any of JAK2, CALR, and MPL, and/or is high-molecular risk (HMR) based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2. The myelofibrosis may be: primary myelofibrosis, myelofibrosis that develops post-polycythemia vera (post-PV MF), or myelofibrosis that develops post essential thrombocythemia (post-ET MF). In certain embodiments, the patient has not previously received JAK-inhibitor therapy. In other embodiment, the patient has previously received JAK-inhibitor therapy and has failed JAK-inhibitor therapy,or has previously received JAK-inhibitor therapy and has discontinued JAK-inhibitor therapy due to treatment-related toxicities or intolerance.
[0022] In certain embodiments of the method of treating, the telomerase inhibitor is imetelstat and is administered for 1, 2, 3, 4, 5, 6, 7, 8, or more than 8 dosage cycles, each cycle comprising: intravenous administration of about 7-10 mg/kg imetelstat once every three weeks; intravenous administration of about 7-10 mg/kg imetelstat once weekly for three weeks; intravenous administration of about 2.5-10 mg/kg imetelstat once every three weeks; or intravenous administration of about 0.5-9.4 mg/kg imetelstat once every three weeks. In certain embodiments, each dosage cycle comprises intravenous administration of about 7-10 mg/kg imetelstat once every three weeks. In other embodiments, each dosage cycle comprises intravenous administration of about 9.4 mg/kg imetelstat once every three weeks.
[0023] In some embodiments of the methods of identifying or selecting a patient most likely to benefit from treatment with a telomerase inhibitor, the method further comprises determining average relative telomere length by analyzing the relative length of telomeric nucleic acids in target cells present in a biological sample from the patient. In some embodiments of the methods of identifying or selecting a patient most likely to benefit from treatment with a telomerase inhibitor, the method further comprises selecting the patient identified as having an average relative telomere length in target cells present in a biological sample from the patient determined to be in the 50th percentile or less of a relative telomere length range determined from one or more known standards. In certain embodiments, the telomerase inhibitor is imetelstat or a pharmaceutically acceptable salt thereof. In other embodiments, the imetelstat is imetelstat sodium.
[0024] The present disclosure provides a method of treating a patient that has myelofibrosis with a telomerase inhibitor comprising: administering the telomerase inhibitor to the patient if such patient is triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL. In certain embodiments, the telomerase inhibitor is imetelstat or a pharmaceutically acceptable salt thereof. In other embodiments, the imetelstat is imetelstat sodium.
[0025] The present disclosure provides a method of treating a patient that has myelofibrosis with a telomerase inhibitor comprising: administering the telomerase inhibitor to the patient if such patient is triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL, and/or is high-molecular risk (HMR) based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2. In certain embodiments, the telomerase inhibitor is imetelstat or a pharmaceutically acceptable salt thereof. In other embodiments, the imetelstat is imetelstat sodium.
[0026] The present disclosure provides a method of treating a patient that has myelofibrosis with a telomerase inhibitor comprising: administering the telomerase inhibitor to the patient if such patient has one or more of the following characteristics:
[0027] (a) average relative telomere length in target cells present in a biological sample from the individual that is determined to be in the 50th percentile or less of a relative telomere length range determined from one or more known standards;
[0028] (b) triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL; and
[0029] (c) high-molecular risk (HMR) based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2. In certain embodiments, the telomerase inhibitor is imetelstat or a pharmaceutically acceptable salt thereof. In other embodiments, the imetelstat is imetelstat sodium.
[0030] The present disclosure provides a method of identifying a subject with myelofibrosis (MF) for treatment with a telomerase inhibitor, the method comprising: measuring hTERT expression level in a biological sample obtained from the patient after administration of a telomerase inhibitor; and comparing the hTERT expression level in the biological sample to a baseline hTERT expression level prior to administration of the telomerase inhibitor; wherein a reduction in hTERT expression level in the biological sample identifies a patient who has an increased likelihood of benefiting from treatment with the telomerase inhibitor.
[0031] The present disclosure provides a method of treating myelofibrosis (MF), the method comprising: administering to a subject in need thereof an effective amount of a telomerase inhibitor; and assessing hTERT expression level in a biological sample obtained from the patient after administration of the telomerase inhibitor. In certain embodiments, the telomerase inhibitor is imetelstat or a pharmaceutically acceptable salt thereof. In other embodiments, the imetelstat is imetelstat sodium.
[0032] The present disclosure provides a method of monitoring therapeutic efficacy in a subject with myelofibrosis (MF), the method comprising: measuring hTERT expression level in a biological sample obtained from the patient after administration of a telomerase inhibitor; and comparing the hTERT expression level in the biological sample to a baseline hTERT expression level prior to administration of the telomerase inhibitor; wherein a 50% or greater reduction in hTERT expression level in the biological sample identifies a subject who has an increased likelihood of benefiting from treatment with the telomerase inhibitor. In certain embodiments, the telomerase inhibitor is imetelstat or a pharmaceutically acceptable salt thereof. In other embodiments, the imetelstat is imetelstat sodium.
[0033] The present disclosure provides a method of selecting a patient most likely to benefit from treatment with a telomerase inhibitor comprising: testing a patient for average relative telomere length, by analyzing the relative length of telomeric nucleic acids in target cells present in a biological sample from the patient; and selecting the patient if the patient has average relative telomere length in target cells present in a biological sample from the patient that is determined to be in the 50th percentile or less of a relative telomere length range determined from one or more known standards, wherein the selected patient is most likely to benefit from treatment with a telomerase inhibitor.
[0034] The present disclosure provides a method of identifying a patient most likely to benefit from treatment with a telomerase inhibitor comprising: obtaining a biological sample from a patient; determining average relative telomere length by analyzing the relative length of telomeric nucleic acids in target cells present in the biological sample from the patient; and identifying the patient if the patient has average relative telomere length in target cells present in the biological sample from the patient that is determined to be in the 50th percentile or less of a relative telomere length range determined from one or more known standards, wherein the identified patient is most likely to benefit from treatment with a telomerase inhibitor.
[0035] The present disclosure provides a method of treating a patient that has myelofibrosis with a telomerase inhibitor comprising: administering the telomerase inhibitor to the patient if such patient has average relative telomere length in target cells present in a biological sample from the patient that is determined to be in the 50th percentile or less of a relative telomere length range determined from one or more known standards. In certain embodiments, the telomerase inhibitor is imetelstat or a pharmaceutically acceptable salt thereof. In other embodiments, the imetelstat is imetelstat sodium.
[0036] The present disclosure provides a method of monitoring therapeutic efficacy in a subject with myelofibrosis (MF), the method comprising measuring hTERT expression level in a biological sample obtained from the patient after administration of a telomerase inhibitor; and comparing the hTERT expression level in the biological sample to a baseline hTERT expression level prior to administration of the telomerase inhibitor; wherein a 50% or greater reduction in hTERT expression level in the biological sample identifies a subject who has an increased likelihood of benefiting from treatment with the telomerase inhibitor. In certain embodiments, the hTERT expression level measured or assessed is hTERT RNA expression level. In certain embodiments, the telomerase inhibitor is imetelstat or a pharmaceutically acceptable salt thereof. In other embodiments, the imetelstat is imetelstat sodium.
[0037] The present disclosure provides a method of identifying a patient with myelofibrosis (MF) for treatment with a telomerase inhibitor, the method comprising: measuring hTERT expression level in a biological sample obtained from the patient after administration of a telomerase inhibitor; and comparing the hTERT expression level in the biological sample to a baseline hTERT expression level prior to administration of the telomerase inhibitor; wherein a reduction in hTERT expression level in the biological sample identifies a patient who has an increased likelihood of benefiting from treatment with the telomerase inhibitor.
[0038] The present disclosure provides a method of monitoring therapeutic efficacy in a subject with myelofibrosis (MF), the method comprising: measuring telomerase activity level in a biological sample obtained from the patient after administration of a telomerase inhibitor; and comparing the telomerase activity level in the biological sample to a baseline telomerase activity level prior to administration of the telomerase inhibitor; wherein a 50% or greater reduction in telomerase activity level in the biological sample identifies a subject who has an increased likelihood of benefiting from treatment with the telomerase inhibitor. In certain embodiments, the telomerase inhibitor is imetelstat or a pharmaceutically acceptable salt thereof. In other embodiments, the imetelstat is imetelstat sodium.
DRAWINGS
[0039] The foregoing summary, as well as the following detailed description of the invention, will be better understood when read in conjunction with the appended figures. For the purpose of illustrating the invention, the figures demonstrate embodiments of the present invention. It should be understood, however, that the invention is not limited to the precise arrangements, examples, and instrumentalities shown.
[0040] FIG. 1 shows a waterfall plot of spleen volume reduction (SVR) at week 24 for the 4.7 mg/kg and 9.4 mg/kg treatment arms in Example 1. The SVR is shown as a percent change from baseline.
[0041] FIG. 2 shows a waterfall plot of total symptom score reduction (TSS) at week 24 for the 4.7 mg/kg and 9.4 mg/kg treatment arms in Example 1. The TSS is shown as a percent change from baseline.
[0042] FIG. 3 shows a Kaplan-Meier Plot of Overall Survival Grouped by Mutation Status of JAK2/MPL/CALR Genes: TN vs. Non-TN (MUT) for the 4.7 mg/kg arm. Specifically, FIG. 3 shows the survival probability for patients having triple negative status (TN) and patients having at least one mutation (MUT) as a function of time.
[0043] FIG. 4 shows a Kaplan-Meier Plot of Overall Survival Grouped by Mutation Status of JAK2/MPL/CALR Genes: TN vs. Non-TN (MUT) for the 9.4 mg/kg arm. Specifically, FIG. 4 shows the survival probability for patients having triple negative status (TN) and patients having at least one mutation (MUT) as a function of time for the 9.4 mg/kg arm.
[0044] FIG. 5 shows a Kaplan-Meier Plot of Overall Survival as a function of time grouped according to patients in the 9.4 mg/kg versus 4.7 mg/kg arm.
[0045] FIG. 6 shows a Kaplan-Meier Plot of Overall Survival (OS) Grouped by Mutation Status of JAK2/MPL/CALR Genes: TN vs. Non-TN for the 9.4 mg/kg arm. Specifically, FIG. 6 shows the survival probability for patients having triple negative status (TN) and patients having at least one mutation (non-TN) as a function of time for the 9.4 mg/kg arm.
[0046] FIG. 7 shows a Kaplan-Meier Plot of Overall Survival (OS) Grouped by Mutation Status of JAK2/MPL/CALR Genes: TN vs. Non-TN for the 4.7 mg/kg arm. Specifically, FIG. 7 shows the survival probability for patients having triple negative status (TN) and patients having at least one mutation (non-TN) as a function of time for the 4.7 mg/kg arm.
DETAILED DESCRIPTION
[0047] This application is based on the discovery that patients that have myelofibrosis, that are triple negative (i.e. the absence of a mutation in each of JAK2, CALR, and MPL), and/or that are in a high-molecular risk (HMR) category, based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2, are able to benefit from treatment with a telomerase inhibitor, such as imetelstat or imetelstat sodium. Patients having mutations in ASXL1, EZH1, IDH1/2, and SRSF2 genes have an elevated risk for early death or leukemic transformation. These patients typically do not benefit from treatment using conventional therapies, such as JAK inhibitors. Gisslinger et al., Blood, 128: 1931 (2016). Thus, the fact that these patients benefit from treatment with a telomerase inhibitor is unexpected and surprising.
[0048] Accordingly, this application provides for methods of identifying a patient most likely to benefit from treatment with a telomerase inhibitor, such as imetelstat. The methods comprise testing or identifying a patient to determine if the patient has triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL; and/or is high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2. The application also provides for methods of treating myelofibrosis with telomerase inhibitor, such as imetelstat, which involve identifying a patient that has: triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL; and/or a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2. Such patients are most likely to benefit from treatment with a telomerase inhibitor. The telomerase inhibitor (e.g. imetelstat) is then administered to the patient. For clarity of disclosure, and not by way of limitation, the detailed description of the invention is divided into subsections that describe or illustrate certain features, embodiments, or applications of the present invention.
A. Definitions
[0049] As used herein, a mutation in additional sex combs like 1 (ASXL1), enhancer of zeste homolog 2 (EZH2), serine and arginine rich splicing factor 2 (SRSF2), and isocitrate dehydrogenase 1/2 (IDH1/2) shall include any mutation in these genes that impacts survival and disease progression in a patient having myelofibrosis. Furthermore, as used herein IDH1/2 shall include IDH1 and IHD2. Exemplary mutations may be found in the following publications, the disclosure of each of which is being incorporated as it pertains to disclosing genetic mutations associated with myelofibrosis: Langabeer, JAK-STAT, 5: e1248011 (2016); Cervantes, Blood; 124(17):2635-2642 (2014); Patel et al., Blood; 126(6):790-797 (2015); Spiegel et al., Blood Adv., 1(20):1729-1738 (2017); Newburry et al., Blood,130(9):1125-1131 (2017); Kuykendall et al., Annals of Hematology, 97: 435-431 (2018). Exemplary sequences are as follows: high-molecular risk (HMR) may be determined based on the presence of a mutation in at least one of the following genes: a ASXL1 gene having, for example, the nucleic acid sequence of SEQ ID NO: 5, a EZH2 gene having, for example, the nucleic acid sequence of SEQ ID NO: 6, a SRSF2 gene having, for example, the nucleic acid sequence of SEQ ID NO: 7, an IDH1 gene having, for example, the nucleic acid sequence of SEQ ID NO: 8, an IDH2 gene having the nucleic acid sequence of SEQ ID NO: 9, and combinations thereof.
[0050] In some embodiments, mutations of interest in the ASXL1 gene include mutations of Q575, Q588, Y591, Q592, 5604, L614, Q623, A627, E635, T638, A640, G646, G658, R678, C687, D690, R693, Y700, G704, E705, Q708, G710, L721, E727, V751, P763, Q780, W796, V807, T822, K825, 5846, D855, C856, L857, L885, L890, S903, 5970, Y974, R965, G967, V962, L992, 51028, Q1039, R1073, E1102, H1153, S1209, 51231, A1312, F1305, P1377, R1415 and 11436. In some embodiments, the mutation is a Q575X mutation, a Q588X, a Y591X mutation, a Y591N mutation, a Q592X mutation, a 5604F mutation, a L614F mutation, a Q623X mutation, a A627G mutation, a E635R mutation, a T638V mutation, a A640G mutation, a G646W mutation, a G658X mutation, a R678K mutation, a C687R mutation, a C687V mutation, a D690G mutation, a R693X mutation, a Y700X mutation, a G704R mutation, a G704W mutation, a E705X mutation, a Q708X mutation, a G710E mutation, a L721C mutation, a E727X mutation, a V751L mutation, a P763R mutation, a Q780X mutation, a W796X mutation, a W796G mutation, a V807F mutation, a T822H mutation, a K825X mutation, a S846Q mutation, a D855A mutation, a C856X mutation, a L857R mutation, a L885X mutation, a L890F mutation, a S903I mutation, a 5970N mutation, a Y974X mutation, a R965X mutation, a G967del mutation, a V962A mutation, a L992Q mutation, a 51028R mutation, a Q1039L mutation, a R1073C mutation, a E1102D mutation, a H1153R mutation, a S12091 mutation, a 51231F mutation, a A1312V mutation, a F1305W mutation, a P13775 mutation, a R1415Q mutation and/or a I1436M mutation.
[0051] In some embodiments, mutations of interest in the EZH2 gene include mutations of W60, R63, P312, F145, N182, R288, Q328, Q553, R566, T573, R591, R659, D677, V679, R690, A702, V704, E726, D730 and/or Y733. In some embodiments, the mutation is a W60X mutation, a R63X mutation, a P3125 mutation, a F145S mutation, a N182D mutation, a R288Q mutation, a Q328X mutation, a Q553X mutation, a R566H mutation, a T573I mutation, a R591H mutation, a R659K mutation, a D677H mutation, a V679M mutation, a R690H mutation, a A702V mutation, a V704L mutation, a E726V mutation, a D730X mutation and/or a Y733X mutation.
[0052] In some embodiments, mutations of interest in the SRSF2 gene include mutations of P95. In some embodiments, the mutation is a P95H mutation, a P95L mutation or a P95R mutation.
[0053] In some embodiments, mutations of interest in the IDH1/2 gene include mutations of R132 and/or R140. In some embodiments, the mutation is a R132G mutation, a R132H mutation or a R140Q mutation.
[0054] In certain embodiment, mutations of interest include those set forth below:
TABLE-US-00001 Gene Protein Change ASXL1 p.Tyr591* Nonsense ASXL1 p.Gln592* Nonsense ASXL1 p.Ile617* Nonsense ASXL1 p.Glu635Argfs*15 Frameshift ASXL1 p.Gly646Trpfs*12 Frameshift ASXL1 p.Asp667Trpfs*2 Frameshift ASXL1 p.Gln692* Nonsense ASXL1 p.Arg693* Nonsense ASXL1 p.Arg693Ter Nonsense ASXL1 p.Tyr700Ilefs*3 Nonsense ASXL1 p.Lys726* Nonsense ASXL1 p.Gln760Hisfs*13 Frameshift ASXL1 p.Leu775* Nonsense ASXL1 p.Trp796* Frameshift ASXL1 p.Pro808fs Frameshift ASXL1 p.Pro808His Missense ASXL1 p.Pro808Leufs*10 Frameshift ASXL1 p.Leu823* Nonsense ASXL1 p.Gly826Glufs*12 Frameshift ASXL1 p.Ala861Aspfs*6 Frameshift ASXL1 p.Pro938* Nonsense ASXL1 p.Asn986Ser Missense ASXL1 p.Gln1234* Nonsense ASXL1 p.Thr1388Serfs*5 Frameshift EZH2 p.Lys400_Glu401del In-Frame Deletion EZH2 p.Cys457Tyr Missense EZH2 p.Ser480Argfs*3 Frameshift EZH2 p.Cys552Tyr Missense EZH2 p.Leu56Phefs*2 Frameshift EZH2 p.Ser669Arg Missense EZH2 p.Asp681_Lys685del In-Frame Deletion EZH2 p.Arg684Cys Missense EZH2 p.Tyr733* Nonsense EZH2 p.Glu745Lys Missense EZH2 p.Ile223Phefs*18 Frameshift SRSF2 p.Pro95Ala Missense SRSF2 p.Pro95His Missense SRSF2 p.Pro95Arg Missense SRSF2 p.Pro95Leu Missense SRSF2 p.Pro107His Missense IDH1 p.Arg132His Missense IDH2 p.Arg140Gln Missense
[0055] As used herein, "triple negative status", "triple negative" or "TN" shall refer to patients having the absence of a mutation in each of Janus kinase 2 (JAK2), calreticulin (CALR), and thrombopoietin receptor (MPL) genes. Triple negative status may be determined based on the absence of a mutation in each of a JAK2 gene having, for example, the nucleic acid sequence of SEQ ID NO: 2, a CALR gene having, for example, the nucleic acid sequence of SEQ ID NO: 3, and a MPL gene having, for example, the nucleic acid sequence of SEQ ID NO: 4.
[0056] In certain embodiments, triple negative status includes an absence of a mutation in the JAK2 gene, such as a mutation at G335, F556, G571, V617 and/or V625. For example, triple negative status may include the absence in the JAK2 gene of a G335D mutation, a F556V mutation, a G5715 mutation, a V617F mutation and/or a V625S mutation.
[0057] In certain embodiments, triple negative status includes an absence of a mutation in the MPL gene, such as a mutation at T119, S204, P222, E230, V285, R321, S505, W515, Y591 and/or R592. For example, triple negative status may include the absence in the MPL gene of a T119I mutation, a S204F mutation, a S204P mutation, a P222S mutation, a E230G mutation, a V285E mutation, a R321W mutation, a S505N mutation, a W515R mutation, a W515L mutation, a Y591N mutation and/or a R592Q mutation.
[0058] In certain embodiments, triple negative status includes an absence of a mutation in the CALR gene, such as a mutation at L367, K368, E381, K385 and/or E396. For example, triple negative status may include the absence in the CALR gene of a L367T mutation, a K368R mutation, a K385N mutation, a E381A mutation and/or a E396del mutation.
[0059] In certain embodiments, mutations of interest include those set forth below:
TABLE-US-00002 Gene Protein Change JAK2 p.Val617Phe Missense MPL p.Ser505Asn Missense MPL p.Trp515Lys Missense MPL p.Trp515Leu Missense CALR p.Leu367Thrfs*46 Frameshift CALR p.Leu367fs Frameshift CALR p.Glu381Ala Missense CALR p.Lys385Asnfs*47 Frameshift CALR p.Glu396del In-Frame Deletion CALR p.Lys368Argfs*51 Frameshift
[0060] As used herein, a patient has "failed" JAK inhibitor therapy when the disease was resistant or the patient was refractory to the therapy or although initially responsive to treatment, the disease has relapsed.
[0061] As used herein, the term "about" when referring to a measurable value such as an amount, a temporal duration, and the like, is meant to encompass variations of between .+-.20% and .+-.0.1%, preferably .+-.20% or .+-.10%, more preferably .+-.5%, even more preferably .+-.1%, and still more preferably .+-.0.1% from the specified value, as such variations are appropriate to perform the disclosed methods.
[0062] The term "pharmaceutically acceptable salt" means a salt which is acceptable for administration to a patient, such as a mammal (salts with counterions having acceptable mammalian safety for a given dosage regime). Such salts can be derived from pharmaceutically acceptable inorganic or organic bases and from pharmaceutically acceptable inorganic or organic acids. "Pharmaceutically acceptable salt" refers to pharmaceutically acceptable salts of a compound, which salts are derived from a variety of organic and inorganic counter ions well known in the art and include, by way of example only, sodium, and the like; and when the molecule contains a basic functionality, salts of organic or inorganic acids, such as hydrochloride, and the like. Pharmaceutically acceptable salts of interest include, but are not limited to, aluminum, ammonium, arginine, barium, benzathine, calcium, cholinate, ethylenediamine, lysine, lithium, magnesium, meglumine, procaine, potassium, sodium, tromethamine, N-methylglucamine, N,N'-dibenzylethylene-diamine, chloroprocaine, diethanolamine, ethanolamine, piperazine, zinc, diisopropylamine, diisopropylethylamine, triethylamine and triethanolamine salts.
[0063] The term "salt(s) thereof" means a compound formed when a proton of an acid is replaced by a cation, such as a metal cation or an organic cation and the like. Preferably, the salt is a pharmaceutically acceptable salt. By way of example, salts of the present compounds include those wherein the compound is protonated by an inorganic or organic acid to form a cation, with the conjugate base of the inorganic or organic acid as the anionic component of the salt. Salts of interest include, but are not limited to, aluminum, ammonium, arginine, barium, benzathine, calcium, cesium, cholinate, ethylenediamine, lithium, magnesium, meglumine, procaine, N-methylglucamine, piperazine, potassium, sodium, tromethamine, zinc, N,N'-dibenzylethylene-diamine, chloroprocaine, diethanolamine, ethanolamine, piperazine, diisopropylamine, diisopropylethylamine, triethylamine and triethanolamine salts. It is understood that for any of the oligonucleotide structures depicted herein that include a backbone of internucleoside linkages, such oligonucleotides may also include any convenient salt forms. In some embodiments, acidic forms of the internucleoside linkages are depicted for simplicity. In some instances, the salt of the subject compound is a monovalent cation salt. In certain instances, the salt of the subject compound is a divalent cation salt. In some instances, the salt of the subject compound is a trivalent cation salt. "Solvate" refers to a complex formed by combination of solvent molecules with molecules or ions of the solute. The solvent can be an organic compound, an inorganic compound, or a mixture of both. Some examples of solvents include, but are not limited to, methanol, N,N-dimethylformamide, tetrahydrofuran, dimethylsulfoxide, and water. When the solvent is water, the solvate formed is a hydrate.
[0064] "Stereoisomer" and "stereoisomers" refer to compounds that have same atomic connectivity but different atomic arrangement in space. Stereoisomers include for example cis-trans isomers, E and Z isomers, enantiomers, and diastereomers. As to any of the groups disclosed herein which contain one or more substituents, it is understood, of course, that such groups do not contain any substitution or substitution patterns which are sterically impractical and/or synthetically non-feasible. All stereoisomers are intended to be included within the scope of the present disclosure.
[0065] A person of ordinary skill in the art would recognize that other tautomeric arrangements of the groups described herein are possible. It is understood that all tautomeric forms of a subject compound are encompassed by a structure where one possible tautomeric arrangement of the groups of the compound is described, even if not specifically indicated.
[0066] It is intended to include a solvate of a pharmaceutically acceptable salt of a tautomer of a stereoisomer of a subject compound. These are intended to be included within the scope of the present disclosure.
[0067] Before certain embodiments are described in greater detail, it is to be understood that this invention is not limited to certain embodiments described, and as such may, of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing certain embodiments only, and is not intended to be limiting, since the scope of the present invention will be limited only by the appended claims.
[0068] Where a range of values is provided, it is understood that each intervening value, to the tenth of the unit of the lower limit unless the context clearly dictates otherwise, between the upper and lower limit of that range and any other stated or intervening value in that stated range, is encompassed within the invention. The upper and lower limits of these smaller ranges may independently be included in the smaller ranges and are also encompassed within the invention, subject to any specifically excluded limit in the stated range. Where the stated range includes one or both of the limits, ranges excluding either or both of those included limits are also included in the invention.
[0069] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described herein can also be used in the practice or testing of the present invention, representative illustrative methods, and materials are now described.
[0070] All publications and patents cited in this specification are herein incorporated by reference as if each individual publication or patent were specifically and individually indicated to be incorporated by reference and are incorporated herein by reference to disclose and describe the methods and/or materials in connection with which the publications are cited. The citation of any publication is for its disclosure prior to the filing date and should not be construed as an admission that the present invention is not entitled to antedate such publication by virtue of prior invention. Further, the dates of publication provided may be different from the actual publication dates, which may need to be independently confirmed.
[0071] It is noted that, as used herein and in the appended claims, the singular forms "a", "an", and "the" include plural referents unless the context clearly dictates otherwise. It is further noted that the claims may be drafted to exclude any optional element. As such, this statement is intended to serve as antecedent basis for use of such exclusive terminology as "solely," "only" and the like in connection with the recitation of claim elements,or use of a "negative" limitation.
[0072] Each of the individual embodiments described and illustrated herein have discrete components and features which may be readily separated from or combined with the features of any of the other several embodiments without departing from the scope or spirit of the present invention. Any recited method may be carried out in the order of events recited or in any other order which is logically possible.
B. Identifying a Patient most Likely to Benefit from Treatment with a Telomerase Inhibitor
[0073] In one aspect, the present disclosure provides for methods of identifying or selecting a patient having myelofibrosis most likely to benefit from treatment with a telomerase inhibitor. The methods rely on identifying triple negative status patients (patients having the absence of a mutation in each of JAK2, CALR, and MPL genes) or patients that are high-molecular risk (HMR) based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2. These triple negative patients or HMR patients are most likely to benefit from treatment with a telomerase inhibitor, such as imetelstat or imetelstat sodium.
[0074] The myelofibrosis may be primary myelofibrosis, myelofibrosis that develops post-polycythemia vera (post-PV MF), or myelofibrosis that develops post essential thrombocythemia (post-ET MF). In certain embodiments, the patient has not previously received JAK-inhibitor therapy. In other embodiments, the patient has previously received JAK-inhibitor therapy and has failed JAK-inhibitor therapy (i.e., the disease was resistant or the patient was refractory to the therapy or although initially responsive to treatment, the disease has relapsed). In other embodiments, the patient has previously received JAK-inhibitor therapy and has discontinued JAK-inhibitor therapy due to treatment-related toxicities or intolerance. In yet alternate embodiments, the patient has previously received JAK-inhibitor therapy and has discontinued JAK-inhibitor therapy.
[0075] In one embodiment, the patient has received JAK-inhibitor therapy and the myelofibrosis was resistant to JAK-inhibitor therapy. In another embodiment, the patient has received JAK-inhibitor therapy and the patient was refractory to JAK-inhibitor therapy. In another embodiments, the patient has received JAK-inhibitor therapy and the patient is relapsed. In an alternate embodiment, the patient has received JAK-inhibitor therapy and discontinued JAK-inhibitor therapy due to treatment-related toxicities or intolerance.
[0076] In one embodiment, the invention provides for methods of selecting a patient most likely to benefit from treatment with a telomerase inhibitor by testing for one or more of: triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL genes (i.e. the lack of any mutation). In that embodiment, the patient may also be tested for a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2. In another embodiment, the invention provides for methods of selecting a patient most likely to benefit from treatment with a telomerase inhibitor by testing for: triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL genes (i.e. the lack of any mutation); and/or a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2. In another embodiment, the invention provides for a method of identifying a patient most likely to benefit from treatment with a telomerase inhibitor comprising testing a patient for: (a) triple negative status, based on the absence of any mutation in JAK2, CALR, and MPL genes; (b) a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2; or (c) both. In this embodiment, the presence of (a), (b), or (c) is indicative of a patient most likely to benefit from treatment with a telomerase inhibitor.
[0077] Another embodiment of the invention is a method of identifying a patient most likely to benefit from treatment with a telomerase inhibitor comprising:
[0078] a. testing a patient for the following:
[0079] i. triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL genes, and/or
[0080] ii. a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2,
[0081] b. selecting the patient if the patient has the following:
[0082] i. triple negative status, based on no mutation in each of JAK2, CALR, and MPL genes, and/or
[0083] ii. a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2, wherein the selected patient is most likely to benefit from treatment with a telomerase inhibitor.
[0084] Yet another embodiment of the invention is a method of identifying a patient most likely to benefit from treatment with a telomerase inhibitor comprising: testing a patient for triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL genes; and selecting the patient if the patient has: triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL genes, wherein the selected patient is most likely to benefit from treatment with a telomerase inhibitor. In one embodiment, this method also includes testing a patient for a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2 and selecting the patient if the patient has a HMR.
[0085] In certain embodiments of any of these methods, the triple negative patients lack a mutation in the coding region (exon) of the JAK2, CALR, and MPL genes.
[0086] Furthermore, in other embodiments of any of these methods, a high-molecular risk (HMR) is determined by the presence of a mutation in the coding region (exon) of at least one of the ASXL1, EZH2, SRSF2, and IDH1/2 genes.
[0087] In certain embodiment, a high-molecular risk (HMR) is determined by detecting the presence of a mutation in ASXL1, EZH2, SRSF2 or IDH1/2 or combination thereof. In some embodiments, methods include detecting the presence of a mutation in ASXL1. In some embodiments, methods include detecting the presence of a mutation in EZH2. In some embodiments, methods include detecting the presence of a mutation in SRSF2. In some embodiments, methods include detecting the presence of a mutation in IDH1/2. In some embodiments, methods include detecting the presence of a mutation in ASXL1 and EZH2. In some embodiments, methods include detecting the presence of a mutation in ASXL1 and SRSF2. In some embodiments, methods include detecting the presence of a mutation in ASXL1 and IDH1/2. In some embodiments, methods include detecting the presence of a mutation in EZH2, SRSF2. In some embodiments, methods include detecting the presence of a mutation in EZH2 and IDH1/2. In some embodiments, methods include detecting the presence of a mutation in SRSF2 and IDH1/2. In some embodiments, methods include detecting the presence of a mutation in ASXL1, EZH2 and SRSF2. In some embodiments, methods include detecting the presence of a mutation in ASXL1, EZH2 and IDH1/2. In some embodiments, methods include detecting the presence of a mutation in EZH2, SRSF2 and IDH1/2. In some embodiments, methods include detecting the presence of a mutation in ASXL1, EZH2, SRSF2 and IDH1/2. In yet another embodiment of the invention, the invention provides for a method of identifying or selecting a patient most likely to benefit from treatment with a telomerase inhibitor in a patient population. In this method, the patient population is screened for patients having mutations in each of JAK2, CALR, and MPL genes to identify triple negative patients in the population. In alternate embodiments, the methods rely on identifying triple negative patients lacking a canonical mutation in each of JAK2, MPL, and CALR.
[0088] In certain embodiments, the methods also include a step of taking a patient DNA sample. The patient sample may be collected from a DNA sample obtained from bone marrow, peripheral blood or both. Accordingly, in certain embodiments, the methods of invention include obtaining a patient blood sample and isolating (extracting) the DNA from the patient blood sample. The methods may also include a step of isolating cells (e.g. granulocytes) from the patient blood sample. Similarly, the methods of the invention include obtaining a bone marrow sample and isolating (extracting) the DNA from the bone marrow sample. The method may also include the step of isolating cells from the patient bone sample.
[0089] The patient DNA sample is tested for the presence or absence of mutations in each of the JAK2, CALR, and MPL genes using conventional techniques. Alternatively, the patient DNA sample is tested for the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2 using conventional techniques. In certain embodiments, patient DNA sample is tested for: (i) the presence or absence of mutations in each of the JAK2, CALR, and MPL genes; and (ii) the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2.
[0090] In certain embodiments, the testing of the DNA sample may be next generation sequencing assay using the Illumina MiSeq platform as disclosed in Patel et al., Blood; 126(6):790-797 (2015), the disclosure of which as it pertains to DNA sample testing is incorporated herein.
C. Pharmacodynamics (PD)
[0091] The present disclosure is based in part on a pharmacodynamic effect demonstrating an association between response to telomerase inhibition therapy in subjects with myelofibrosis and a decrease in telomerase hTERT expression levels in the subjects from baseline levels. In some cases, a higher % of subjects achieve a 50% or more decrease in hTERT RNA expression levels in subjects who achieved clinical response (spleen or symptom) to telomerase inhibition therapy at week 24 than those who did not achieve response.
[0092] The present disclosure provides for stratification and selection of patients likely to benefit from telomerase inhibition therapy for myelofibrosis, and provides methods of monitoring response, relapse, and prognosis in subjects undergoing treatment.
[0093] Aspects of the present disclosure include methods selecting subjects with myelofibrosis (MF) for treatment with a telomerase inhibitor, and methods of treating MF. Methods of monitoring therapeutic efficacy in a subject with MF are also provided. In some case, the pharmacodynamic effect on which an embodiment of the subject methods is based is reduction of hTERT RNA expression by 50% or more, such as 60% or more, 70% or more, 80% or more, or 90% or more.
[0094] The telomerase ribonucleoprotein consists of components or subunits, two of these being telomerase RNA template (hTR), and telomerase reverse transcriptase protein (hTERT). hTERT expression levels can be assessed, determined and/or measured using any convenient methods. A variety of methods can be applied for the amplification, detection and measurement of mRNA of telomerase components or related proteins in bodily fluids. Methods and assays of interest which may be adapted for use in the subject methods include, but are not limited to, real-time quantitative RT-PCR assays, e.g., based on based on TaqMan fluorescence methodology, immunohistochemistry methods for protein expression, and methods described by U.S. Pat. No. 6,607,898, Bieche et al., Clin. Cancer Res Feb. 1 2000 (6) (2) 452-459, Terrin et al. ("Telomerase expression in B-cell chronic lymphocytic leukemia predicts survival and delineates subgroups of patients with the same igVH mutation status and different outcome." Leukemia 2007; 21: 965-972), and Palma et al. ("Telomere length and expression of human telomerase reverse transcriptase splice variants in chronic lymphocytic leukemia." Experimental Hematology 2013; 41: 615-626).
[0095] The hTERT expression levels can be assessed or measured in any convenient target cells or biological samples. Target cells can be any convenient cells of the patient, including but not limited to, cells of the bone marrow or peripheral blood of the patient. In some cases, the target cells are isolated from a bone marrow sample of the patient. In some cases, the target cells are isolated from a peripheral blood sample of the patient. The target cells can be granulocytes.
[0096] hTERT RNA expression levels can be assessed or measured in a RNA sample using any convenient methods. A RNA sample may be obtained by first obtaining a bone marrow sample, a peripheral blood sample, or both and then isolating the RNA from the bone marrow sample, the peripheral blood sample, or both. In one embodiment, the step of obtaining a sample from a patient comprises: obtaining a bone marrow sample from the patient, isolating cells from the bone marrow sample, and extracting RNA and/or DNA from the isolated cells. In another embodiment, the step of obtaining a RNA sample from a patient comprises: obtaining a peripheral blood sample from the patient; isolating cells from the peripheral blood sample (e.g. granulocytes); and extracting RNA and/or DNA from the isolated cells.
D. Treatment
[0097] Aspects of the present disclosure include methods of treating myelofibrosis in a subject in need thereof (i.e. patient) having: triple negative status, based on the absence of any mutation in JAK2, CALR, and MPL genes (i.e. no mutation in these genes or these genes lacking mutation); and/or high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2. One embodiment of the invention is a method of treating myelofibrosis in a subject in need thereof (i.e. patient) having: triple negative status, based on the absence of any mutation in JAK2, CALR, and MPL genes (i.e. no mutation in these genes or lacking a mutation). In one embodiment, the myelofibrosis is primary myelofibrosis. In another embodiment, the myelofibrosis is myelofibrosis that develops post-polycythemia vera (post-PV MF). In an alternate embodiment, the myelofibrosis is myelofibrosis that develops post essential thrombocythemia (post-ET MF).
[0098] In certain embodiments of the treatment methods, the patient has not previously received JAK-inhibitor therapy. In other embodiments, the patient has previously received JAK-inhibitor therapy and has "failed" JAK-inhibitor therapy (i.e., the disease was resistant or the patient was refractory to the therapy or although initially responsive to treatment, the disease has relapsed). In alternate embodiments of the treatment methods, the patient has received JAK-inhibitor therapy and has discontinued JAK-inhibitor therapy, due to treatment-related toxicities or intolerance. In certain embodiments, the methods of treating further include premedication with diphenhydramine (25 to 50 mg) and hydrocortisone (100 to 200 mg), or equivalent thereof.
[0099] A subject is a mammal in need of treatment for cancer. Generally, the subject is a human patient. In some embodiments of the invention, the subject can be a non-human mammal such as a non-human primate, an animal model (e.g., animals such as mice and rats used in screening, characterization, and evaluation of medicaments) and other mammals. As used herein, the terms patient, subject and individual are used interchangeably.
[0100] As used herein, and as well understood in the art, "treatment" is an approach for obtaining beneficial or desired results, including clinical results. For purposes of this invention, beneficial or desired clinical results include, but are not limited to, alleviation or amelioration of one or more symptoms, diminishment of extent of disease, stabilized (i.e., not worsening) state of disease, preventing spread of disease, delay or slowing of disease progression, amelioration or palliation of the disease state, and remission (whether partial or total), whether detectable or undetectable. "Treatment" can also mean prolonging survival as compared to expected survival if not receiving treatment.
E. Telomerase Inhibitors
[0101] The methods of the invention may be used to identify a patient most likely to benefit from treatment with any convenient telomerase inhibitors. Furthermore, any convenient telomerase inhibitors can find use in the subject treatment methods. In some embodiments, the telomerase inhibitor is an oligonucleotide with telomerase inhibiting activity, in particular an oligonucleotide as defined in WO 2005/023994 and/or WO 2014/088785, the disclosures of which are herein incorporated by reference in their entirety. In some cases, one or more than one telomerase inhibitor (e.g., two or three telomerase inhibitors) can be administered to a mammal to treat a hematological malignancy.
[0102] Imetelstat
[0103] In certain embodiments, the telomerase inhibitor is imetelstat, including tautomers thereof and salts thereof, e.g., pharmaceutically acceptable salts. Imetelstat is a novel, first-in-class telomerase inhibitor with clinical activity in hematologic malignancies (Baerlocher et al., NEJM 2015; 373:920-928; Tefferi et al., NEJM 2015; 373:908-919) (shown below):
##STR00001##
[0104] where "nps" represents a thiophosphoramidate linkage --NH--P(.dbd.O)(SH)--O--, connecting the 3'-carbon of one nucleoside to the 5'-carbon of the adjacent nucleoside.
[0105] In certain instances, the telomerase inhibitor is imetelstat sodium including tautomers thereof. Imetelstat sodium is the sodium salt of imetelstat, which is a synthetic lipid-conjugated, 13-mer oligonucleotide N3'.fwdarw.P5'-thio-phosphoramidate. Imetelstat sodium is a telomerase inhibitor that is a covalently-lipidated 13-mer oligonucleotide (shown below) complimentary to the human telomerase RNA (hTR) template region. The chemical name for imetelstat sodium is: DNA, d(3'-amino-3'-deoxy-P-thio) (T-A-G-G-G-T-T-A-G-A-C-A-A), 5'-[O-[2-hydroxy-3-(hexadecanoylamino)propyl] phosphorothioate], sodium salt (1:13) (SEQ ID NO: 1). Imetelstat sodium does not function through an anti-sense mechanism and therefore lacks the side effects commonly observed with such therapies.
##STR00002##
[0106] Unless otherwise indicated or clear from the context, references herein to imetelstat also include tautomers thereof and salts thereof, e.g., pharmaceutically acceptable salts. As mentioned, imetelstat sodium in particular is the sodium salt of imetelstat. Unless otherwise indicated or clear from the context, references herein to imetelstat sodium also include all tautomers thereof.
[0107] Imetelstat and imetelstat sodium can be produced, formulated, or obtained as described elsewhere (see e.g. Asai et al., Cancer Res., 63:3931-3939 (2003), Herbert et al., Oncogene, 24:5262-5268 (2005), and Gryaznov, Chem. Biodivers., 7:477-493 (2010)). Unless otherwise indicated or clear from the context, references herein to imetelstat also include salts thereof. As mentioned, imetelstat sodium in particular is the sodium salt of imetelstat.
[0108] Imetelstat targets the RNA template of telomerase and inhibits telomerase activity and cell proliferation in various cancer cell lines and tumor xenografts in mice. Phase 1 studies involving patients with breast cancer, non-small-cell lung cancer and other solid tumors, multiple myeloma, or chronic lymphocytic leukemia have provided information on drug pharmacokinetics and pharmacodynamics. A subsequent phase 2 study involving patients with essential thrombocythemia showed platelet-lowering activity accompanied by a significant reduction in JAK2 V617F and CALR mutant allele burdens. Imetelstat sodium is routinely administered intravenously; it is contemplated that in the practice of the subject methods other administration routes also can be used, such as intrathecal administration, intratumoral injection, oral administration and others. Imetelstat sodium can be administered at doses comparable to those routinely utilized clinically. In certain embodiments, imetelstat sodium is administered as described elsewhere herein.
[0109] A particular embodiment is according to any one of the other embodiments, wherein imetelstat is limited to imetelstat sodium.
F. Pharmaceutical Compositions
[0110] For ease of administration, the telomerase inhibitor (e.g., as described herein) may be formulated into various pharmaceutical forms for administration purposes. In some cases, the telomerase inhibitor is administered as a pharmaceutical composition. The carrier or diluent of the pharmaceutical composition must be "acceptable" in the sense of being compatible with the other ingredients of the composition and not deleterious to the recipients thereof. The pharmaceutical composition may be in unitary dosage form suitable, in particular, for administration orally, rectally, percutaneously, by parenteral injection or by inhalation. In some cases, administration can be via intravenous injection. For example, in preparing the composition in oral dosage form, any of the usual pharmaceutical media may be employed such as, for example, water, glycols, oils, alcohols and the like in the case of oral liquid preparations such as suspensions, syrups, elixirs, emulsions and solutions; or solid carriers such as starches, sugars, kaolin, diluents, lubricants, binders, disintegrating agents and the like in the case of powders, pills, capsules and tablets. Because of their ease in administration, tablets and capsules represent the most advantageous oral dosage unit forms in which case solid pharmaceutical carriers are obviously employed. For parenteral compositions, the carrier will usually comprise sterile water, at least in large part, though other ingredients, for example, to aid solubility, may be included. Injectable solutions, for example, may be prepared in which the carrier comprises saline solution, glucose solution or a mixture of saline and glucose solution. Injectable solutions, for example, may be prepared in which the carrier comprises saline solution, glucose solution or a mixture of saline and glucose solution. Injectable solutions containing the telomerase inhibitor described herein may be formulated in oil for prolonged action. Appropriate oils for this purpose are, for example, peanut oil, sesame oil, cottonseed oil, corn oil, soybean oil, synthetic glycerol esters of long chain fatty acids and mixtures of these and other oils. Injectable suspensions may also be prepared in which case appropriate liquid carriers, suspending agents and the like may be employed. Also included are solid form preparations that are intended to be converted, shortly before use, to liquid form preparations. In the compositions suitable for percutaneous administration, the carrier optionally comprises a penetration enhancing agent and/or a suitable wetting agent, optionally combined with suitable additives of any nature in minor proportions, which additives do not introduce a significant deleterious effect on the skin. Said additives may facilitate the administration to the skin and/or may be helpful for preparing the desired composition. The composition may be administered in various ways, e.g., as a transdermal patch, as a spot-on, as an ointment.
[0111] It is especially advantageous to formulate the aforementioned pharmaceutical compositions in unit dosage form for ease of administration and uniformity of dosage. Unit dosage form as used herein refers to physically discrete units suitable as unitary dosages, each unit containing a predetermined quantity of active ingredient calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier. Examples of such unit dosage forms are tablets (including scored or coated tablets), capsules, pills, powder packets, wafers, suppositories, injectable solutions or suspensions and the like, and segregated multiples thereof.
[0112] In order to enhance the solubility and/or the stability of the drug described herein in pharmaceutical compositions, it can be advantageous to employ .alpha.-, .beta.- or .gamma.-cyclodextrins or their derivatives, in particular hydroxyalkyl substituted cyclodextrins, e.g. 2 hydroxypropyl-.beta.-cyclodextrin or sulfobutyl-.beta.-cyclodextrin. Also, co-solvents such as alcohols may improve the solubility and/or the stability of the telomerase inhibitor in pharmaceutical compositions.
[0113] Depending on the mode of administration, the pharmaceutical composition will preferably comprise from 0.05 to 99% by weight, more preferably from 0.1 to 70% by weight, even more preferably from 0.1 to 50% by weight of the telomerase inhibitor described herein, and from 1 to 99.95% by weight, more preferably from 30 to 99.9% by weight, even more preferably from 50 to 99.9% by weight of a pharmaceutically acceptable carrier, all percentages being based on the total weight of the composition.
G. Administration and Administration Regimens
[0114] The frequency of administration can be any frequency that reduces the severity of a symptom of myelofibrosis without producing significant toxicity to the subject. For example, the frequency of administration can be from about once every two months to about once a week, alternatively from about once a month to about twice a month, alternatively about once every six weeks, about once every 5 weeks, alternatively about once every 4 weeks, alternatively about once every 3 weeks, alternatively about once every 2 weeks or alternatively about once a week. The frequency of administration can remain constant or can be variable during the duration of treatment. A course of treatment with a composition containing one or more telomerase inhibitors can include rest periods. For example, a composition containing a telomerase inhibitor can be administered weekly over a three-week period followed by a two-week rest period, and such a regimen can be repeated multiple times. As with the effective amount, various factors can influence the actual frequency of administration used for a particular application. For example, the effective amount, duration of treatment, use of multiple treatment agents, route of administration, and severity of the myelofibrosis and related symptoms may require an increase or decrease in administration frequency.
[0115] An effective duration for administering a composition containing a telomerase inhibitor (e.g., imetelstat or imetelstat sodium) can be any duration that reduces the severity of a symptom of myelofibrosis (e.g., as described herein) without producing significant toxicity to the subject. Thus, the effective duration can vary from one month to several months or years (e.g., one month to two years, one month to one year, three months to two years, three months to ten months, or three months to 18 months). In general, the effective duration for the treatment of myelofibrosis can range in duration from two months to twenty months. In some cases, an effective duration can be for as long as an individual subject is alive. Multiple factors can influence the actual effective duration used for a particular treatment. For example, an effective duration can vary with the frequency of administration, effective amount, use of multiple treatment agents, route of administration, and severity of the myelofibrosis and related symptoms.
[0116] In certain instances, a course of treatment and the severity of one or more symptoms related to myelofibrosis can be monitored. Any method can be used to determine whether or not the severity of a symptom of myelofibrosis is reduced. For example, the severity of a symptom of myelofibrosis (e.g., as described herein) can be assessed using biopsy techniques.
[0117] Telomerase inhibitors as used in the subject methods can be administered at any dose that is therapeutically effective, such as doses comparable to those routinely utilized clinically. Specific dose regimens for known and approved anti-cancer agents (e.g., the recommended effective dose) are known to physicians and are given, for example, in the product descriptions found in the PHYSICIANS'' DESK REFERENCE, 2003, 57th Ed., Medical Economics Company, Inc., Oradell, N.J.; Goodman & Gilman's THE PHARMACOLOGICAL BASIS OF THERAPEUTICS'' 2001, 10th Edition, McGraw-Hill, New York; and/or are available from the Federal Drug Administration and/or are discussed in the medical literature.
[0118] In some aspects, the dose of a telomerase inhibitor, imetelstat sodium, administered to the subject is about 1.0 mg/kg to about 13.0 mg/kg. In other aspects, the dose of a telomerase inhibitor is about 4.5 mg/kg to about 11.7 mg/kg or about 6.0 mg/kg to about 11.7 mg/kg or about 6.5 mg/kg to about 11.7 mg/kg. In some embodiments, the dose of a telomerase inhibitor includes at least about any of 4.5 mg/kg, 4.6 mg/kg, 4.7 mg/kg, 4.8 mg/kg, 4.9 mg/kg, 5.0 mg/kg, 5.5 mg/kg, 6.0 mg/kg, 6.1 mg/kg, 6.2 mg/kg, 6.3 mg/kg, 6.4 mg/kg, 6.5 mg/kg, 6.6 mg/kg, 6.7 mg/kg, 6.8 mg/kg, 6.9 mg/kg, 7 mg/kg, 7.1 mg/kg, 7.2 mg/kg, 7.3 mg/kg, 7.4 mg/kg, 7.5 mg/kg, 7.6 mg/kg, 7.7 mg/kg, 7.8 mg/kg, 7.9 mg/kg, 8 mg/kg, 8.1 mg/kg, 8.2 mg/kg, 8.3 mg/kg, 8.4 mg/kg, 8.5 mg/kg, 8.6 mg/kg, 8.7 mg/kg, 8.8 mg/kg, 8.9 mg/kg, 9 mg/kg, 9.1 mg/kg, 9.2 mg/kg, 9.3 mg/kg, 9.4 mg/kg, 9.5 mg/kg, 9.6 mg/kg, 9.7 mg/kg, 9.8 mg/kg, 9.9 mg/kg, 10 mg/kg, 10.1 mg/kg, 10.2 mg/kg, 10.3 mg/kg, 10.4 mg/kg, 10.5 mg/kg, 10.6 mg/kg, 10.7 mg/kg, 10.8 mg/kg, 10.9 mg/kg, 11 mg/kg, 11.1 mg/kg, 11.2 mg/kg, 11.3 mg/kg, 11.4 mg/kg, 11.5 mg/kg, 11.6 mg/kg, 11.7 mg/kg, 11.8 mg/kg, 11.9 mg/kg, 12 mg/kg, 12.1 mg/kg, 12.2 mg/kg, 12.3 mg/kg, 12.4 mg/kg, 12.5 mg/kg, 12.6 mg/kg, 12.7 mg/kg, 12.8 mg/kg, 12.9 mg/kg, or 13 mg/kg.
[0119] In some embodiments, the effective amount of a telomerase inhibitor administered to the individual includes at least about any of 1 mg/kg, 2.5 mg/kg, 3.5 mg/kg, 4.7 mg/kg, 5 mg/kg, 5.5 mg/kg, 6.0 mg/kg, 6.5 mg/kg, 7.0 mg/kg, 7.5 mg/kg, 8.0 mg/kg, 8.5 mg/kg, 9.0 mg/kg, 9.4 mg/kg, 10 mg/kg, 15 mg/kg, or 20 mg/kg. In some embodiments, the effective amount of a telomerase inhibitor administered to the individual is about any of 1 mg/kg, 2.5 mg/kg, 3.5 mg/kg, 4.7 mg/kg, 5 mg/kg, 6.5 mg/kg, 7.5 mg/kg, 9.4 mg/kg, 10 mg/kg, 15 mg/kg, or 20 mg/kg. In various embodiments, the effective amount of a telomerase inhibitor administered to the individual includes less than about any of 350 mg/kg, 300 mg/kg, 250 mg/kg, 200 mg/kg, 150 mg/kg, 100 mg/kg, 50 mg/kg, 30 mg/kg, 25 mg/kg, 20 mg/kg, 10 mg/kg, 7.5 mg/kg, 6.5 mg/kg, 5 mg/kg, 3.5 mg/kg, 2.5 mg/kg, 1 mg/kg, or 0.5 mg/kg of a telomerase inhibitor.
[0120] Exemplary dosing frequencies for the pharmaceutical composition including a telomerase inhibitor include, but are not limited to, daily; every other day; twice per week; three times per week; weekly without break; weekly, three out of four weeks; once every three weeks; once every two weeks; weekly, two out of three weeks. In some embodiments, the pharmaceutical composition is administered about once every week, once every 2 weeks, once every 3 weeks, once every 4 weeks, once every 5 weeks, once every 6 weeks, once every 7 weeks or once every 8 weeks. In some embodiments, the composition is administered at least about any of 1.times., 2.times., 3.times., 4.times., 5.times., 6.times., or 7.times. (i.e., daily) a week, or three times daily, two times daily. In some embodiments, the intervals between each administration are less than about any of 6 months, 3 months, 1 month, 20 days, 15 days, 12 days, 10 days, 9 days, 8 days, 7 days, 6 days, 5 days, 4 days, 3 days, 2 days, or 1 day. In some embodiments, the intervals between each administration are more than about any of 1 month, 2 months, 3 months, 4 months, 5 months, 6 months, 8 months, or 12 months. In some embodiments, there is no break in the dosing schedule. In some embodiments, the interval between each administration is no more than about a week.
[0121] Telomerase inhibitors such as imetelstat (e.g., imetelstat sodium) can be administered using any appropriate method. For example, telomerase inhibitors such as imetelstat (e.g., imetelstat sodium) can be administered intravenously once every 4 weeks over a period of time (e.g., one, two, three, four, or five hours). In some embodiments, imetelstat is administered intravenously once weekly over a period of about 2 hours at 7-10 mg/kg. In certain embodiments, imetelstat is administered intravenously once every 3 weeks over a period of about 2 hours about 0.5-9.4 mg/kg. In an embodiment, imetelstat is administered intravenously for a period of about 2 hours once every 4 weeks at 0.5-5 mg/kg. In an embodiment, imetelstat is administered intravenously once every 3 weeks over a period of about 2 hours at about 2.5-10 mg/kg. Alternatively, imetelstat is administered intravenously for a period of about 2 hours once every 4 weeks at about 0.5-9.4 mg/kg.
[0122] In certain embodiments of the method, imetelstat is administered for 1, 2, 3, 4, 5, 6, 7, 8 or more than 8 dosage cycles, each cycle comprising: intravenous administration of about 7-10 mg/kg imetelstat once every three weeks, intravenous administration of about 7-10 mg/kg imetelstat once weekly for three weeks, intravenous administration of about 2.5-10 mg/kg imetelstat once every three weeks, or intravenous administration of about 0.5-9.4 mg/kg imetelstat once every three weeks. In certain instance, each dosage cycle comprises intravenous administration of about 7-10 mg/kg imetelstat once every three weeks. In some cases, each dosage cycle comprises intravenous administration of about 9.4 mg/kg imetelstat about once every three weeks.
[0123] In one embodiment of the invention, imetelstat is administered intravenously at a dosage of about 7-10 mg/kg imetelstat once every three weeks following premedication with an antihistamine, corticosteroid, or both. In other embodiments, imetelstat is administered intravenously at a dosage of about 9.4 mg/kg, alternatively from about 7.0 mg/kg to about 9.8 mg/kg, imetelstat once every three weeks following premedication with an antihistamine, corticosteroid, or both.
[0124] In certain embodiments, imetelstat is administrated at a dosage about 7.5 mg/kg, alternatively from about 7.0 mg/kg to about 7.7 mg/kg, once every three weeks for at least three cycles and then the dosage is increased. In certain embodiments, the dosage of imetelstat may be increased to about 9.4 mg/kg, alternatively from about 8.8 mg/kg to about 9.6 kg/mg, provided ANC and platelet nadir have not dropped between about 1.5.times.10.sup.9/L and about 75.times.10.sup.9/L, respectively, and there is no grade .gtoreq.3 non-hematological toxicity.
[0125] It will be appreciated that treatment for cancer sometimes involves multiple "rounds" or "cycles" of administration of a drug, where each cycle comprises administration of the drug one or more times according to a specified schedule (e.g., every three weeks for three consecutive days; once per week; etc.). For example, anti-cancer drugs can be administered for from 1 to 8 cycles, or for a longer period. When more than one drug (e.g., two drugs) is administered to a subject, each can be administered according to its own schedule (e.g., weekly; once every three weeks; etc.). It will be clear that administration of drugs, even those administered with different periodicity, can be coordinated so that both drugs are administered on the same day at least some of the time or, alternatively, so the drugs are administered on consecutive days at least some of the time.
[0126] In certain embodiments, the imetelstat may be administered via a regimen which involves dose reductions. In one embodiment, the patient is initially administered about 9.4 mg/kg every three weeks, the dose is then changed to about 7.5 mg/kg every three weeks, and then the dose is changed to about 6.0 mg/kg every three weeks.
[0127] As is understood in the art, treatment with cancer therapeutic drugs can be suspended temporarily if toxicity is observed, or for the convenience of the patient, without departing from the scope of the invention, and then resumed.
[0128] Aspects of the subject methods include identifying or selecting a patient most likely to benefit from treatment based on relative telomere length in target cells (e.g. as described herein) of the patient. Target cells can be any convenient cells of the patient, including but not limited to, cells of the bone marrow or peripheral blood of the patient. In some cases, the target cells are isolated from a bone marrow sample of the patient. In some cases, the target cells are isolated from a peripheral blood sample of the patient. The target cells can be granulocytes. In some cases, the patient lacks a mutation in each of Janus kinase 2 (JAK2), calreticulin (CALR), and thrombopoietin receptor (MPL) genes; and has a particular short telomere length in target cells of the patient. As used herein, a short telomere length is one that is less than or equal to the median or mean telomere length, as compared to a suitable control, e.g., one or more known standards as described herein. As such, the subject methods can further include determining relative telomere length by analyzing the relative length of telomeric nucleic acids in target cells present in a biological sample from the individual; selecting an individual who will benefit from treatment with a telomerase inhibitor when the average relative telomere length in the target cells present in a biological sample from the individual is determined to be in the 50th percentile or less of a relative telomere length range determined from one or more known standards, such as determined to be in the 45th percentile or less, 40th percentile or less, 35th percentile or less, 30th percentile or less, 25th percentile or less, 20th percentile or less, or even less, of a relative telomere length range determined from one or more known standards
[0129] In some instances of the method, the one or more known standards is a telomere length range established from a plurality of naturally occurring target cells (e.g. as described herein) from a plurality of individuals diagnosed with the disease. In certain instances of the method, the one or more known standards are characterized cell lines. By "characterized cell lines" it is meant that the relative telomeric nucleic acids of the cells in the cell lines are known and relatively constant.
[0130] In some embodiments, the telomere length in the cancer cells present in the biological sample is determined to be less than or equal to the median or mean telomere length. In some embodiments, the telomere length in the cancer cells present in the biological sample is determined to be in the 50th percentile or less, 40th percentile or less, 35th percentile or less, 30th percentile or less, 25th percentile or less, 20th percentile or less, 15th percentile or less, 10th percentile or less, or 5th percentile or less, of the relative telomere length range determined from the one or more known standards.
[0131] Telomere length in a target cell can be determined using any convenient assays, including but not limited to, qPCR, telo-FISH, or Southern Blot assays, as described by Bassett et al. in U.S. Pat. No. 9,200,327. In one aspect, telomere length can be determined by measuring the mean length of a terminal restriction fragment (TRF). The TRF is defined as the length--in general the average length--of fragments resulting from complete digestion of genomic DNA with a restriction enzyme that does not cleave the nucleic acid within the telomeric sequence. In some cases, the DNA is digested with restriction enzymes that cleaves frequently within genomic DNA but does not cleave within telomere sequences. In some cases, the restriction enzymes have a four base recognition sequence (e.g., AluI, HinfI, RsaI, and Sau3A1) and are used either alone or in combination. The resulting terminal restriction fragment contains both telomeric repeats and subtelomeric DNA. Subtelomeric DNA are DNA sequences adjacent to tandem repeats of telomeric sequences and contain telomere repeat sequences interspersed with variable telomeric-like sequences. The digested DNA is separated by electrophoresis and blotted onto a support, such as a membrane. The fragments containing telomere sequences are detected by hybridizing a probe, i.e., labeled repeat sequences, to the membrane. Upon visualization of the telomere containing fragments, the mean lengths of terminal restriction fragments can be calculated (Harley, C. B. et al., Nature. 345(6274):458-60 (1990), hereby incorporated by reference). TRF estimation by Southern blotting gives a distribution of telomere length in the cells or tissue, and thus the median and mean telomere length of all cells.
[0132] In another aspect, telomere lengths can be measured by flow cytometry (Hultdin, M. et al., Nucleic Acids Res. 26: 3651-3656 (1998); Rufer, N. et al., Nat. Biotechnol. 16:743-747 (1998); incorporated herein by reference). Flow cytometry methods are variations of FISH techniques. If the starting material is tissue, a cell suspension is made, generally by mechanical separation and/or treatment with proteases. Cells are fixed with a fixative and hybridized with a telomere sequence specific probe, preferably a PNA probe, labeled with a fluorescent label. Following hybridization, cells are washed and then analyzed by FACS. Fluorescence signal is measured for cells in Go/G1 following appropriate subtraction for background fluorescence. This technique is suitable for rapid estimation of telomere length for large numbers of samples. Similar to TRF, telomere length is the average length of telomeres within the cell.
[0133] In other aspects, the median or average length of telomeres from cells within a biological sample is determined via quantitative PCR (qPCR) or telomere fluorescent in situ hybridization (telo-FISH). In qPCR, a DNA binding dye binds to all double-stranded DNA causing fluorescence of the dye. An increase in DNA product during the PCR reaction leads to an increase in the fluorescence intensity and is measured at each cycle of the PCR reaction. This allows the DNA concentration to be quantified. The relative concentration of the DNA present during the exponential phase of the reaction is determined by plotting the level of fluorescence against the PCR cycle number on a semi-logarithmic scale. A threshold for detection of fluorescence above background is determined. The cycle at which the fluorescence from the sample crosses the threshold is called the cycle threshold (Ct). Because the quantity of DNA theoretically doubles every cycle during the exponential phase, the relative amounts of DNA can be calculated. The baseline is the initial cycles of PCR, in which there is little change in fluorescence signal.
[0134] In some aspects, telomere length is determined using telo-FISH. In this method, cells are fixed and hybridized with a probe conjugated to a fluorescent label, for example, Cy-3, fluoresceine, rhodamine, etc. Probes for this method are oligonucleotides designed to hybridize specifically to telomere sequences. Generally, the probes are 8 or more nucleotides in length, such as 12-20 or more nucleotides in length. In one aspect, the probes are oligonucleotides comprising naturally occurring nucleotides. In one aspect, the probe is a peptide nucleic acid, which has a higher Tm than analogous natural sequences, and thus permits use of more stringent hybridization conditions. Cells may be treated with an agent, such as colcemid, to induce cell cycle arrest at metaphase provide metaphase chromosomes for hybridization and analysis. In some embodiments, cellular DNA can also be stained with the fluorescent dye 4',6-diamidino-2-phenylindole (DAPI).
[0135] Digital images of intact metaphase chromosomes are acquired and the fluorescence intensity of probes hybridized to telomeres quantitated. This permits measurement of telomere length of individual chromosomes, in addition to average or median telomere length in a cell, and avoids problems associated with the presence of subtelomeric DNA (Zjilmans, J. M. et al., Proc. Natl. Acad Sci. USA 94:7423-7428 (1997); Blasco, M. A. et al., Cell 91:25-34 (1997); incorporated by reference). The intensity of the fluorescent signal correlates with the length of the telomere, with a brighter fluorescent signal indicating a longer telomere.
[0136] In certain embodiments, the invention relates to a telomerase inhibitor for use in a method of treating myelofibrosis, the method comprising: identifying a patient most likely to benefit from treatment with a telomerase inhibitor comprising testing a patient for:
[0137] (a) triple negative status, based on the absence of any mutation in JAK2, CALR, and MPL genes;
[0138] (b) high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2; or
[0139] (c) both;
[0140] wherein the presence of (a), (b) or (c) is indicative of a patient most likely to benefit from treatment with a telomerase inhibitor and administering to the patient an effective amount of a telomerase inhibitor. In certain embodiments, the invention relates to a telomerase inhibitor for use in a method as defined in any of the other embodiments.
[0141] Yet another embodiment of the invention is a telomerase inhibitor for use in the treatment of myelofibrosis comprising: (a) screening a patient to determine if such patient is: triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL and/or a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2; and; (b) administering the telomerase inhibitor to the patient if such patient is triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL, and/or is high-molecular risk (HMR) based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2. In one embodiment, the use comprises screening the patient for triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL. Yet another embodiment of the invention is a telomerase inhibitor for use in the treatment of myelofibrosis comprising: (a) screening a patient to determine if such patient is: triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL; and (b) administering the telomerase inhibitor to the patient if such patient is triple negative status.
[0142] Yet another embodiment of the invention is use of a telomerase inhibitor for the treatment of myelofibrosis comprising: (a) screening a patient to determine if such patient is: triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL and/or a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2; and; (b) administering the telomerase inhibitor to the patient if such patient is triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL, and/or is high-molecular risk (HMR) based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2. In one embodiment, the use comprises screening the patient for triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL. Yet another embodiment of the invention is use of a telomerase inhibitor for the treatment of myelofibrosis comprising: (a) screening a patient to determine if such patient is: triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL; and (b) administering the telomerase inhibitor to the patient if such patient is triple negative status.
[0143] In certain embodiments of the invention, triple negative status may be determined based on the absence of a mutation in each of a JAK2 gene having the nucleic acid sequence of SEQ ID NO: 2, a CALR gene having the nucleic acid sequence of SEQ ID NO: 3, and a MPL gene having the nucleic acid sequence of SEQ ID NO: 4. In other embodiments, triple negative status may be determined based on the absence of a mutation in each of SEQ ID NO: 2; CALR, and MPL. In an alternate embodiment, triple negative status may be determined based on the absence of a mutation in each of JAK2, SEQ ID NO: 3, and MPL. In an alternate embodiment, triple negative status may be determined based on the absence of a mutation in each of JAK2, CALR, and SEQ ID NO: 4.
[0144] In other embodiments of the invention, high-molecular risk (HMR) may be determined based on the presence of a mutation in at least one of the following genes: a ASXL1 gene having the nucleic acid sequence of SEQ ID NO: 5, a EZH2 gene having the nucleic acid sequence of SEQ ID NO: 6, a SRSF2 gene having the nucleic acid sequence of SEQ ID NO: 7, an IDH1 gene having the nucleic acid sequence of SEQ ID NO: 8, an IDH2 gene having the nucleic acid sequence of SEQ ID NO: 9, and combinations thereof.
[0145] In other embodiments of the invention, telomerase activity and level of hTERT expression in biological samples obtained from patients can be determined to evaluate pharmacodynamic effects and/or monitor patients being treated with a telomerase inhibition. The telomerase activity can be measured using the TRAP (Telomeric Repeat Amplification Protocol) telomerase activity assay. The level of hTERT expression can be determined by measuring the level of hTERT RNA expression in the cells in the biological sample using northern blots or serial analysis of gene expression (SAGE) or other methods.
[0146] In certain embodiments, the invention relates to a telomerase inhibitor for use in the treatment of myelofibrosis as defined in any of the other embodiments.
[0147] In certain embodiments, the invention relates to the use of a telomerase inhibitor for the treatment of myelofibrosis as defined in any of the other embodiments.
Additional Embodiments
[0148] Additional embodiments of interest are set forth in the following clauses:
[0149] Clause 1. A method of identifying a patient most likely to benefit from treatment with a telomerase inhibitor comprising:
[0150] (a) testing a patient for triple negative status, based on the absence of a mutation in each of Janus kinase 2 (JAK2), calreticulin (CALR), and thrombopoietin receptor (MPL) genes; and
[0151] (b) selecting the patient if the patient has triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL genes, wherein the selected patient is most likely to benefit from treatment with a telomerase inhibitor.
[0152] Clause 2. A method of identifying a patient most likely to benefit from treatment with a telomerase inhibitor comprising:
[0153] (c) testing a patient for the following:
[0154] i. triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL genes, and/or
[0155] ii. a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2,
[0156] (d) selecting the patient that has the following:
[0157] i. triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL genes, and/or
[0158] ii. a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2, wherein the selected patient is most likely to benefit from treatment with a telomerase inhibitor.
[0159] Clause 3. A method of identifying a patient most likely to benefit from treatment with a telomerase inhibitor comprising:
[0160] (e) obtaining a DNA sample from a patient;
[0161] (f) testing the DNA sample from a patient for triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL genes; and
[0162] (g) selecting the patient if the patient has: triple negative status, based on no mutation in each of JAK2, CALR, and MPL genes; wherein the selected patient is most likely to benefit from treatment with a telomerase inhibitor.
[0163] Clause 4. A method of identifying a patient most likely to benefit from treatment with a telomerase inhibitor comprising:
[0164] (h) obtaining a DNA sample from a patient;
[0165] (i) testing the DNA sample from a patient for:
[0166] i. triple negative status, based on the absence of a mutation in each of JAK2, CALR, and MPL genes; and/or
[0167] ii. a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2; and
[0168] (j) selecting the patient if the patient has:
[0169] i. triple negative status, based no mutation in each of JAK2, CALR, and MPL genes; and/or
[0170] ii. a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2, wherein the selected patient is most likely to benefit from treatment with a telomerase inhibitor.
[0171] Clause 5. Use of a telomerase inhibitor in the treatment of patient that has myelofibrosis wherein the patient is determined to have a triple negative status, wherein the triple negative status comprises an absence of a mutation in each of the Janus kinase 2 (JAK2), calreticulin (CALR), and thrombopoietin receptor (MPL) genes.
[0172] Clause 6. Use of a telomerase inhibitor in the treatment of patient that has myelofibrosis wherein the patient is determined to have a high-molecular risk (HMR), wherein having HMR comprises the presence of a mutation in at least one gene selected from the group consisting of additional sex combs like 1 (ASXL1), enhancer of zeste homolog 2 (EZH2), serine and arginine rich splicing factor 2 (SRSF2), and isocitrate dehydrogenase 1/2 (IDH1/2).
[0173] Clause 7. Use of a telomerase inhibitor in the treatment of patient that has myelofibrosis wherein cells present in a biological sample from the patient have been determined to have average relative telomere length that is determined to be in the 50th percentile or less of a relative telomere length range determined from one or more known standards.
[0174] Clause 8. Use of a telomerase inhibitor in the manufacture of a medicament for the treatment of patient that has myelofibrosis wherein the patient is determined to have a triple negative status, wherein the triple negative status comprises an absence of a mutation in each of the Janus kinase 2 (JAK2), calreticulin (CALR), and thrombopoietin receptor (MPL) genes.
[0175] Clause 9. Use of a telomerase inhibitor in the manufacture of a medicament for the treatment of patient that has myelofibrosis wherein the patient is determined to have a high-molecular risk (HMR), wherein having HMR comprises the presence of a mutation in at least one gene selected from the group consisting of additional sex combs like 1 (ASXL1), enhancer of zeste homolog 2 (EZH2), serine and arginine rich splicing factor 2 (SRSF2), and isocitrate dehydrogenase 1/2 (IDH1/2).
[0176] Clause 10. Use of a telomerase inhibitor in the manufacture of a medicament for the treatment of patient that has myelofibrosis wherein cells present in a biological sample from the patient have been determined to have average relative telomere length that is determined to be in the 50th percentile or less of a relative telomere length range determined from one or more known standards.
[0177] The following examples are offered by way of illustration and not by way of limitation.
EXAMPLES
Example 1
Imetelstat Sodium is an Effective Treatment for Patients with Intermediate-2 (Int-2) or High-Risk Myelofibrosis (MF) that have Relapsed or are Refractory to Janus Kinase (JAK) Inhibitor Therapy
Introduction
[0178] Imetelstat, a 13-mer oligonucleotide that specifically targets the RNA template of human telomerase, is a potent competitive inhibitor of telomerase enzymatic activity (Asai et al., Cancer Res 2003; Herbert, Oncogene 2005). Clinical activity and an acceptable safety profile were reported in a 33-patient pilot study in intermediate-2 (int-2) or high-risk myelofibrosis (MF), where 48% of patients had been previously treated with a Janus Kinase inhibitor (JAKi) (Tefferi, N Engl J Med 2015). This example provides the results of a phase 2 clinical study of imetelstat sodium at two dose levels in patients with myelofibrosis (MF).
Methods
[0179] A randomized, multicenter, phase 2 study of two doses of imetelstat sodium (9.4 mg/kg or 4.7 mg/kg IV, every 3 weeks) was performed in adults with: a Dynamic International Prognostic Scoring System (DIPSS) Score of int-2; or high-risk MF that was relapsed/refractory to prior JAKi therapy (i.e., either no reduction in splenomegaly after 12 weeks or worsening splenomegaly at any time after the start of JAK inhibitor ("JAKi") therapy). Diagnosis of primary, post-essential thrombocythemia, or post-polycythemia vera MF was required; other eligibility criteria included measurable splenomegaly (by magnetic resonance imaging [MRI]), active MF-related systemic symptoms and platelet count .gtoreq.75.times.10.sup.9/L. Primary endpoints were: spleen response rate (% achieving .gtoreq.35% spleen volume reduction [SVR] by MRI at week 24); and symptom response rate (% achieving .gtoreq.50% reduction in total symptom score [TSS] per the Myelofibrosis Symptom Assessment Form (MFSAF) v2 at week 24). Key secondary endpoints included safety, overall survival (OS), treatment response, molecular response, and pharmacokinetic and pharmacodynamic relationships.
Results
[0180] 107 patients were enrolled at 55 institutions (48 on 4.7 mg/kg; 59 on 9.4 mg/kg). Baseline characteristics are shown in Table 1 below. Additionally, median time on JAKi was 23 (0.9-89.7) months, and median platelet count was 147.times.10.sup.9/L. Triple-negative (TN; i.e., no mutations of JAK2, MPL, or CALR) comprised 24.8% of patients and 67.6% were considered high molecular risk (HMR; i.e., .gtoreq.1 mutation ofASXL1, EZH2, SRSF2, or IDH1/2).
TABLE-US-00003 TABLE 1 Baseline characteristics 4.7 mg/kg 9.4 mg/kg (n = 48) (n = 59) Median Age (range; years) 68.5 (44, 84) 67.0 (31, 86) Male 32 (66.7%) 35 (59.3%) Myelofibrosis Subtype Primary 27 (56.3%) 36 (61.0%) Post-ET 9 (18.8%) 10 (16.9%) Post-PV 12 (25.0%) 13 (22.0%) DIPSS Risk Status Intermediate-1 risk 1.sup.a (2.1%) 0 Intermediate-2 risk 28 (58.3%) 34 (57.6%) High Risk 19 (39.6%) 25 (42.4%) Spleen Length (Palpation) - Median (range; cm) 18.0 (4.0, 35.0) 18.0 (3.0, 32.0) >15 cm 31 (64.6%) 35 (59.3%) Spleen Volume (MRI) - Median.sup.b (range; cm.sup.3) 3352.8 (726; 7243) 2997.5 (890; 7607) Total Symptom Score - Median (range; TSS) 22.29 (6.7, 58.4) 23.86 (3.1, 57.2) RBC Transfusion dependent.sup.c 14 (29.2%) 12 (20.3%) Platelet count - Median (range; .times.10.sup.9/L) 153 (74, 1097) 146 (65, 798) Time Since Initial Diagnosis - Median (range; 48.90 (2.0; 227.3) 42.84 (6.6; 200.7) months) Time Since Last JAKi Therapy - Median (range; 1.41 (0.5, 31.2) 1.71 (0.5, 37.8) months) Duration of prior JAKi Therapy - Median (range; 22 (3, 90) 25 (1, 73) months) .sup.aProtocol variation .sup.bPer Independent Review Committee .sup.cReceived 6 units PRBC in 12 weeks prior to enrollment.
[0181] At the time of primary clinical cut-off, the median time on study was 22.6 months (range, 0.2-27.4 month); the median time on treatment was 6.2 months (range, 0.0-27.2 months). Six (10.2%) patients in the 9.4 mg/kg arm had a spleen response per MRI confirmed by IRC
[0182] At the time of clinical cutoff, patients were followed for a median 22.6 (0.2-27.4) months, including a median treatment duration of 6.2 (0.0-27.2) months. Median duration on treatment was longer on the 9.4 mg/kg arm (7.7 months) than on the 4.7 mg/kg arm. Six (10.2%) patients in the 9.4 mg/kg arm had a spleen response per MRI, with no responses on the 4.7 mg/kg arm (see FIG. 1). Nineteen (32%) patients in the 9.4 mg/kg arm and 3 (6%) patients in the 4.7 mg/kg arm had a symptom response (TSS reduction .gtoreq.50%) (see FIG. 2).
[0183] Median OS in the 9.4 mg/kg arm has not been reached at the first clinical cutoff, while median OS was 19.9 months in the 4.7 mg/kg arm. The 18-month survival rates were 76.7% and 62.9% for the 9.4 mg/kg and 4.7 mg/kg arms, respectively. Sensitivity analyses censoring patients at time of dose escalation for subsequent JAKi therapy or stem cell transplant generated similar results. In the 9.4 mg/kg arm, an association was observed between patients who were TN and OS (median OS has not been reached for TN patients and was 23.6 months for non-TN patients). Spleen response rate was higher in patients with 1 HMR mutation (ASXL1, EZH2, SRSF2, or IDH1/2).
[0184] The most common adverse events on treatment (all grades) at 9.4 mg/kg were thrombocytopenia (49%), anemia (44%), neutropenia (36%), and nausea (34%); and at 4.7 mg/kg were diarrhea (38%), nausea (31%), anemia (31%), and thrombocytopenia (23%). Grade 3/4 neutropenia and thrombocytopenia were more frequent with 9.4 mg/kg (34% and 42%, respectively) than 4.7 mg/kg (13% and 29%, respectively); most cytopenias resolved within 4 weeks. Grade 3/4 LFT elevations were observed in 7 patients on study. Imetelstat-related hepatic toxicities, confirmed by an independent Hepatic Review Committee, were not observed.
[0185] At the time of a second clinical cutoff, patients were followed for a median 27.4 (0.2-33.0) months, including a median treatment duration of 26.9 (0.1-118.1) weeks. Median duration on treatment was longer on the 9.4 mg/kg arm (33.3 weeks) than on the 4.7 mg/kg arm (23.9 weeks). The 4.7 mg/kg arm was closed early, influencing duration of treatment. Median OS with 95% confidence interval in the 9.4 mg/kg arm was 29.9 months (22.8, NE) (NE is not estimable) in the 9.4 mg/kg arm and was reached at the second clinical cutoff.
[0186] Triple Negative vs. OS
[0187] Subjects are grouped by mutation status of JAK2/MPL/CALR genes, triple Negative (TN, the absence of a mutation in each of JAK2/MPL/CALR genes) and Non-TN (with mutation in any of JAK2/MPL/CALR genes). The median OS were not estimable (NE) for TN subjects with 95% confidence interval (23.2, NE) and 23.6 months for Non-TN subjects with 95% confidence interval (20.7, NE) in 9.4 mg/kg arm, while in 4.7 mg/kg, the median OS with 95% confidence were 22.3 (17, NE) and interval 20.3 (18.3, NE) for TN subjects and Non-TN subjects, respectively. In the 9.4 mg/kg arm, a lower death rate was seen in the Triple Negative (TN) group compared to Non-TN group (see Table 2, FIGS. 3 and 4).
TABLE-US-00004 TABLE 2 Overall Survival Grouped by mutation status of JAK2/MPL/CALR genes Dose Median survival, P value (mg/kg) Mut status Death rate % months (95% CI) HR (95% CI) (log rank) 4.7 TN 40 22.3 (17, NE) Non-TN 36.8 20.3 (18.3, NE) 0.98 (0.32, 2.98) 0.9719 9.4 TN 18.8 NE (23.2, NE) Non-TN 41.5 23.6 (20.7, NE) 2.76 (0.81, 9.46) 0.0910
[0188] At the second clinical cutoff, a lower death rate was seen in the 9.4 mg/kg arm in the Triple Negative (TN) group compared to Non-TN group (see Table 3, FIGS. 6 and 7).
TABLE-US-00005 TABLE 3 Overall Survival Grouped by mutation status of JAK2/MPL/CALR genes Percentage Median Imetelstat of Survival Dose Subjects (months) HR* P-value (mg/kg) Mutation Status Who Died (95% CI) (95% CI) (Log-rank) 4.7 Triple Negative 6/10 (60.0%) 23.1 (4.2, NE) (TN) Non-TN (MUT) 21/38 (55.3%) 19.5 (16.7, 31.6) 1.16 (0.46, 2.87) 0.7562 9.4 Triple Negative 4/16 (25.0%) NE (23.2, NE) (TN) Non-TN (MUT) 21/41 (51.2%) 24.6 (19.7, NE) 2.60 (0.89, 7.59) 0.0700 *HR = Hazard Ratio
[0189] Triple-Negative vs. Response at Week 24
[0190] In the 9.4 mg/kg arm, a higher rate of response (SVR or TSS) was seen in the TN group compared to Non-TN group (see Table 4 below).
TABLE-US-00006 TABLE 4 Baseline JAK2/CALR/MPL mutation status by Clinical Response SVR >= 20% at Week 24 by IRC 4.7 mg/kg, N = 48 9.4 mg/kg, N = 57 JAK2/CALR/MPL Total, Yes, Yes, Mutation Status N = 105 Total # N = 2 (4.2%) No, N = 46 (95.8%) Total # N = 12 (21.1%) No, N = 45 (78.9%) TN 26(24.8%) 10 0 (0%) 10 (100%) 16 5 (31.25%) 11 (68.75)) Non-TN 79 (75.2%) 38 2 (5.3%) 36 (94.7%) 41 7 (17.1%) 34 (82.9%) SVR >= 35% at Week 24 by IRC JAK2/CALR/MPL Total, 4.7 mg/kg, N = 48 9.4 mg/kg, N = 57 Mutation Status N = 105 Total # Yes, N = 0 (0%) No, N = 48 (100%) Total # Yes, N = 6 (10.5%) No, N = 51 (89.5%) TN 26(24.8%) 10 0 (0%) 10 (100%) 16 3 (18.75%) 13 (81.25%) Non-TN 79 (75.2%) 38 0 (0%) 38 (100%) 41 3 (7.3%) 38 (92.7%) TSS >= 50% decrease at Week 24 JAK2/CALR/MPL Total, 4.7 mg/kg, N = 48 9.4 mg/kg N = 57 Mutation Status N = 105 Total # Yes, N = 3 (6.3%) No, N = 45 (93.8%) Total # Yes, N = 18 (31.6%) No, N = 39 (68.4%) TN 26(24.8%) 10 1 (10.0%) 9 (90.0%) 16 8 (50%) 8 (50%) Non-TN 79 (75.2%) 38 2 (5.3%) 36 (94.7%) 41 10 (24.4%) 31 (75.6%)
[0191] Molecular Risk vs. Responses at Week 24
[0192] In the 9.4 mg/kg arm, a higher rate of response (SVR or TSS) was seen in low molecular risk (LMR) group or high molecular risk (HMR) group with only 1 mutation (mut) group compared to the HMR group with more than 1 mutations (see Table 5).
TABLE-US-00007 TABLE 5 Molecular Risk vs. Responses at Week 24 SVR >= 20% at week 24 4.7 mg/kg, N = 48 9.4 mg/kg, N = 57 Total, Total Yes, N = 1 No, Total Yes, N = 12 No, N = 45 Molecular Risk N = 105 # (2.1%) N = 47(97.8%) # (21.1%) (78.9%) LMR, 34 12 1 (8.3%) 11 (91.7%) 22 5 (22.7%) 17 (77.3%) No Mutation (32.4%) HMR with 1 Mutation 48 27 0 (0%) 27(100%) 21 6 (28.6%) 15 (71.4%) (45.7%) HMR with >1 23 9 0 (0%) 9 (100%) 14 1 (7.1%) 13 (92.9%) Mutation (21.9%) SVR >= 35% at wk 24 by IRC 4.7 mg/kg, N = 48 9.4 mg/kg, N = 57 Total Total Yes, No, Total Yes, No, N = 51 Molecular Risk N = 105 # N = 0 (0%) N = 48 (100%) # N = 6 (10.5%) (89.5%) LMR, 34 12 0 (0%) 12 (100%) 22 2 (9.1%) 20 (90.9%) No Mutation (32.4%) HMR with 1 Mutation 48 27 0 (0%) 27 (100%) 21 4 (19%) 17 (81%) (45.7%) HMR with >1 23 9 0 (0%) 9 (100%) 14 0 (0%) 14 (100% Mutation (21.9%) TSS >= 50% decrease at week 24 4.7 mg/kg, N = 48 9.4 mg/kg, N = 57 Total, Total Yes, N = 3 No, N = 45 Total Yes, N = 18 No, N = 39 Molecular Risk N = 105 # (6.3%) (93.8%) # (31.6%) (68.4%) LMR, 34 12 3 (25%) 9 (75%) 22 8 (36.4%) 14 (63.6%) No Mutation (32.4%) HMR with 1 Mutation 48 27 0 (0%) 27(100%) 21 7 (33.3%) 14 (66.7%) (45.7%) HMR with >1 23 9 0 (0%) 9 (100%) 14 3 (21.4%) 11 (78.6%) Mutation (21.9%)
[0193] For subjects on 9.4 mg/kg, an association was observed between the following factors and clinical responses or OS:
[0194] Triple Negative (TN): response (SVR or TSS) was enriched in TN subjects. Median OS not estimable for TN, Non-TN=23.6 months; and
[0195] Molecular Risk: response (SVR or TSS) was enriched in subjects with HMR having only 1 mutation, and responses were observed in patients with HMR having greater than one mutation who were treated with 9.4 mg/kg imetelstat.
Example 2
[0196] Baseline Telomere Length (TL) vs. Overall Survival (OS)
[0197] Subjects are grouped by the median value of baseline TL. In the 9.4 mg/kg arm, median OS were not estimable (NE) at the first clinical cutoff with 95% confidence interval (23.2, NE) for subjects with shorter baseline TL (<=median value), and 22.8 months (16.2, NE) for the subjects with longer TL (>median value), respectively (Table 6). In 4.7 mg/kg arm, median OS with 95% confidence interval were 20.3 (17.2, NE) months and 22.3 (16.6, NE) months for subjects with shorter baseline TL and the subjects with longer TL, respectively (Table 6).
[0198] In 9.4 mg/kg arm, a better OS trend was observed for subjects with shorter baseline TL, i.e., a baseline TL less than or equal to the median TL.
TABLE-US-00008 TABLE 6 Overall Survival for Baseline Telomere Length (TL) Grouped by Median Value 4.7 MG/KG 9.4 MG/KG <=Median >Median <=Median >Median N Value Value N Value Value Subjects with 40 18 22 53 29 24 baseline Number 40 18(45.0%) 22(55.0%) 53 29(54.7%) 24(45.3%) assessed Number 20 8(20.0%) 12(30.0%) 35 21(39.6%) 14(26.4%) censored (%) Number of 20 10(25.0%) 10(25.0%) 18 8(15.1%) 10(18.9%) events (%) Overall Survival (months) Median (95% CI) 22.3 (18.2, NE) 20.3 (17.2, 22.3 (16.6, NE (22.8, NE (23.2, 22.8 (16.2, NE) NE) NE) NE) NE) 18-months 68.2 (50.7, 76.7 (49.2, 61.0 (36.7, 75.9 (61.5, 81.2 (60.5, 69.8 (46.9, survival rate % 80.6) 90.6) 78.3) 85.6) 91.7) 84.3) (95% CI) 24-months 39.6 (21.1, 34.1 (10.9, 46.6 (21.8, 54.2 (35.1, 59.3 (30.9, 47.6 (22.1, survival rate % 57.6) 59.3) 68.2) 69.9) 79.3) 69.4) (95% CI)
Baseline TL vs. Responses at Week 24
[0199] Baseline telomere length (TL): SVR or TSS response at week 24 was enriched in subjects with shorter baseline TL (<=median value). 17.3% (5/29) subjects with shorter baseline TL and 4.2% (1/24) subjects with longer baseline TL had a spleen response, respectively. 34.5% (10/29) subjects with shorter baseline TL and 25% (6/24) subjects with longer baseline TL had a TSS response, respectively.
[0200] In 9.4 mg/kg arm, at week 24, a higher rate of response (SVR or TSS) was enriched in subjects with shorter baseline TL compared to subjects with longer TL (Table 7)
TABLE-US-00009 TABLE 7 Baseline Summary of Telomere Length (TL) by Clinical Response SVR >= 35% at week 24 by IRC 4.7 mg/kg, N = 40 9.4 mg/kg N = 53 Total, No, Yes, No, N = 93 Yes, N = 40 N = 6 N = 47 Baseline TL With data Total # N = 0 (0%) (100%) Total # (10.5%) (89.5%) Shorter TL 47 18 0 (0%) 10 (100%) 29 5 (17.25%) 24 (82.75%) (<= Median value Longer TL 46 22 0 (0%) 38 (100%) 24 1 (4.2%) 23 (92.7%) ( >Median value) TSS >= 50% decrease at week 24 4.7 mg/kg, N = 40 9.4 mg/kg N = 53 Total, Yes, No, Yes, No, N = 93 N = 2 N = 38 N = 16 N = 37 Baseline TL With data Total # (5%) (95%) Total # (30.2%) (69.8%) Shorter TL 47 18 1 (5.6%) 17 (94.4%) 29 10 (34.5%) 19 (65.6%) (<= Median value Longer TL 46 22 1 (4.5%) 21 (95.5%) 24 6 (25%) 18 (75%) ( >Median value)
Example 3
Dose-Dependent Pharmacodynamic (PD) Effect
[0201] Telomerase activity and hTERT was analyzed to evaluate pharmacodynamic effects for imetelstat. Among subjects with available baseline and post-treatment data, 23 (51.1%) subjects in 9.4 mg/kg arm and 10 (29.4%) subjects in 4.7 mg/kg arm achieved >=50% telomerase activity reduction from baseline, which is the PD effect showed correlation with anti-tumor activity from preclinical xenograft models in vivo. In addition, 35 (61.4%) subjects in 9.4 mg/kg arm and 20 (47.7%) subjects in 4.7 mg/kg arm achieved >=50% hTERT RNA level reduction from baseline, respectively (Table 8). As such, a dose-dependent PD effect was demonstrated, indicating target engagement.
TABLE-US-00010 TABLE 8 Subjects Achieved Reduction in TA (30%, 50%) or hTERT (50%) from Baseline at Any Timepoints. 4.7 MG/KG 9.4 MG/KG Subjects with Baseline (hTERT) 48 57 hTERT >=50% decrease 20 (41.7%) 35 (61.4%) Subjects with Baseline (TA) 34 45 TA >=30% decrease 14 (41.2%) 28 (62.2%) TA >=50% decrease 10 (29.4%) 23 (51.1%)
Example 4
[0202] Association Between PD Effect and Response at week 24
[0203] Higher % of subjects in spleen responders (83.3%) achieved at least >=50% decrease in hTERT RNA expression levels than in non-spleen responders (55.6%); higher % of subjects who had TSS response achieved at least >=50% decrease in hTERT RNA expression levels than in non-TSS responders (Table 9). hTERT RNA expression levels were measured from whole blood samples collected from patients pre- and post-treatment.
TABLE-US-00011 TABLE 9 Association between reduction in hTERT (50%) from baseline and SVR or TSS response at week 24. hTERT>50% reduction Spleen Response at wk 24 by IRC Yes 5/6 (83.3%) No 55/99 (55.6%) TSS Response at wk 24 Yes 15/24 (62.5%) No 45/81 (55.6%)
[0204] Higher % of subjects who had spleen response or TSS response achieved at least >=30% or >=50% decrease in telomerase activity than in subjects who had no spleen response or TSS response (Table 10).
TABLE-US-00012 TABLE 10 Association between reduction in telomerase activity (30%, 50%) from baseline and SVR or TSS response at week 24. Telomerase Activity >50% reduction >30% reduction Spleen Response at wk 24 by IRC Yes 2/4 (50%) 3/4 (75%) No 34/70 (48.6%) 41/70 (58.6%) TSS Response at wk 24 Yes 12/18 (66.7%) 15/18 (83.3%) No 24/56 (42.9%) 29/56 (51.8%)
[0205] Aspects, including embodiments, of the subject matter described herein may be beneficial alone or in combination, with one or more other aspects or embodiments. Without limiting the description, certain non-limiting aspects of the disclosure are provided below. As will be apparent to those of skill in the art upon reading this disclosure, each of the individually numbered aspects may be used or combined with any of the preceding or following individually numbered aspects. This is intended to provide support for all such combinations of aspects and is not limited to combinations of aspects explicitly provided below:
[0206] 1. Use of a telomerase inhibitor in the treatment of patient that has myelofibrosis wherein the patient is determined to have a triple negative status,
[0207] wherein the triple negative status comprises an absence of a mutation in each of the Janus kinase 2 (JAK2), calreticulin (CALR), and thrombopoietin receptor (MPL) genes.
[0208] 2. The use of 1, wherein the myelofibrosis is primary myelofibrosis.
[0209] 3. The use of 2, wherein the myelofibrosis is myelofibrosis that develops post-polycythemia vera (post-PV MF).
[0210] 4. The use of 2, wherein the myelofibrosis is myelofibrosis that develops post essential thrombocythemia (post-ET MF).
[0211] 5. The use of any one of 1-4, wherein the patient has not previously received JAK-inhibitor therapy.
[0212] 6. The use of any one of 1-4, wherein the patient has received JAK-inhibitor therapy and the patient was refractory to JAK-inhibitor therapy.
[0213] 7. The use of any one of 1-4, wherein the patient has received JAK-inhibitor therapy and is relapsed.
[0214] 8. The use of any one of 1-4, wherein the patient has received JAK-inhibitor therapy and discontinued JAK-inhibitor therapy due to treatment-related toxicities or intolerance.
[0215] 9. The use of any one of 1-8, wherein the telomerase inhibitor is imetelstat.
[0216] 10. The use of 9, wherein the imetelstat is imetelstat sodium.
[0217] 11. The use of 10, wherein the telomerase inhibitor is imetelstat and is administered for 1, 2, 3, 4, 5, 6, 7, 8 or more than 8 dosage cycles, each cycle comprising:
[0218] intravenous administration of about 7-10 mg/kg imetelstat once every three weeks;
[0219] intravenous administration of about 7-10 mg/kg imetelstat once weekly for three weeks;
[0220] intravenous administration of about 2.5-10 mg/kg imetelstat once every three weeks; or
[0221] intravenous administration of about 0.5-9.4 mg/kg imetelstat once every three weeks.
[0222] 12. The use of 11, wherein each dosage cycle comprises intravenous administration of about 7-10 mg/kg imetelstat once every three weeks.
[0223] 13. The use of 12, wherein each dosage cycle comprises intravenous administration of about 9.4 mg/kg imetelstat once every three weeks.
[0224] 14. The use of any one of 1-13, wherein the average relative telomere length is determined by analyzing the relative length of telomeric nucleic acids in target cells present in a biological sample from the patient.
[0225] 15. The use of any one of 1-14, further comprising selecting a patient identified as having an average relative telomere length in target cells present in a biological sample from the patient determined to be in the 50th percentile or less of a relative telomere length range determined from one or more known standards.
[0226] 16. The use of any one of 1-15, further comprising screening a patient to determine if the patient has a high-molecular risk (HMR), wherein having HMR comprises the presence of a mutation in at least one gene selected from the group consisting of ASXL1, EZH2, SRSF2 and IDH1/2.
[0227] 17. The use of any one of 1-16, further comprising assessing hTERT expression level in a biological sample obtained from the patient after administration of the telomerase inhibitor.
[0228] 18. The use of 17, wherein the hTERT expression level is reduced by 50% or more relative to a baseline hTERT expression level prior to administration of the telomerase inhibitor.
[0229] 19. The use of any one of 17-18, further comprising altering the dosage of the telomerase inhibitor, the frequency of dosing, or the course of therapy administered to the subject.
[0230] 20. Use of a telomerase inhibitor in the treatment of patient that has myelofibrosis wherein the patient is determined to have a high-molecular risk (HMR),
[0231] wherein having HMR comprises the presence of a mutation in at least one gene selected from the group consisting of additional sex combs like 1 (ASXL1), enhancer of zeste homolog 2 (EZH2), serine and arginine rich splicing factor 2 (SRSF2), and isocitrate dehydrogenase 1/2 (IDH1/2).
[0232] 21. The use of 20, wherein the myelofibrosis is primary myelofibrosis.
[0233] 22. The use of 21, wherein the myelofibrosis is myelofibrosis that develops post-polycythemia vera (post-PV MF).
[0234] 23. The use of 21, wherein the myelofibrosis is myelofibrosis that develops post essential thrombocythemia (post-ET MF).
[0235] 24. The use of any one of 20-23, wherein the patient has not previously received JAK-inhibitor therapy.
[0236] 25. The use of any one of 20-23, wherein the patient has received JAK-inhibitor therapy and the patient was refractory to JAK-inhibitor therapy.
[0237] 26. The use of any one of 20-23, wherein the patient has received JAK-inhibitor therapy and is relapsed.
[0238] 27. The use of any one of 20-23, wherein the patient has received JAK-inhibitor therapy and discontinued JAK-inhibitor therapy due to treatment-related toxicities or intolerance.
[0239] 28. The use of any one of 20-27, wherein the telomerase inhibitor is imetelstat.
[0240] 29. The use of 28, wherein the imetelstat is imetelstat sodium.
[0241] 30. The use of 28, wherein the telomerase inhibitor is imetelstat and is administered for 1, 2, 3, 4, 5, 6, 7, 8 or more than 8 dosage cycles, each cycle comprising:
[0242] intravenous administration of about 7-10 mg/kg imetelstat once every three weeks;
[0243] intravenous administration of about 7-10 mg/kg imetelstat once weekly for three weeks;
[0244] intravenous administration of about 2.5-10 mg/kg imetelstat once every three weeks; or
[0245] intravenous administration of about 0.5-9.4 mg/kg imetelstat once every three weeks.
[0246] 31. The use of 30, wherein each dosage cycle comprises intravenous administration of about 7-10 mg/kg imetelstat once every three weeks.
[0247] 32. The use of 31, wherein each dosage cycle comprises intravenous administration of about 9.4 mg/kg imetelstat once every three weeks.
[0248] 33. The use of any one of 20-32, further comprising determining average relative telomere length by analyzing the relative length of telomeric nucleic acids in target cells present in a biological sample from the patient.
[0249] 34. The use of any one of 20-33, further comprising selecting a patient identified as having an average relative telomere length in target cells present in a biological sample from the patient determined to be in the 50th percentile or less of a relative telomere length range determined from one or more known standards.
[0250] 35. The use of any one of 20-34, further comprising screening a patient to determine if the patient is triple negative status, wherein the triple negative status comprises an absence of a mutation in each of the genes selected from the group consisting of JAK2, CALR and MPL.
[0251] 36. The use of any one of 20-35, further comprising assessing hTERT expression level in a biological sample obtained from the patient after administration of the telomerase inhibitor.
[0252] 37. The use of 36, wherein the hTERT expression level is reduced by 50% or more relative to a baseline hTERT expression level prior to administration of the telomerase inhibitor.
[0253] 38. The use of any one of 36-37, further comprising altering the dosage of the telomerase inhibitor, the frequency of dosing, or the course of therapy administered to the subj ect.
[0254] 39. Use of a telomerase inhibitor in the treatment of patient that has myelofibrosis wherein cells present in a biological sample from the patient have been determined to have average relative telomere length that is determined to be in the 50th percentile or less of a relative telomere length range determined from one or more known standards.
[0255] 40. The use of 39, wherein the myelofibrosis is primary myelofibrosis.
[0256] 41. The use of 40, wherein the myelofibrosis is myelofibrosis that develops post-polycythemia vera (post-PV MF).
[0257] 42. The use of 40, wherein the myelofibrosis is myelofibrosis that develops post essential thrombocythemia (post-ET MF).
[0258] 43. The use of any one of 39-42, wherein the patient has not previously received JAK-inhibitor therapy.
[0259] 44. The use of any one of 39-42, wherein the patient has received JAK-inhibitor therapy and the patient was refractory to JAK-inhibitor therapy.
[0260] 45. The use of any one of 39-42, wherein the patient has received JAK-inhibitor therapy and is relapsed.
[0261] 46. The use of any one of 39-42, wherein the patient has received JAK-inhibitor therapy and discontinued JAK-inhibitor therapy due to treatment-related toxicities or intolerance.
[0262] 47. The use of any one of 39-46, wherein the telomerase inhibitor is imetelstat.
[0263] 48. The use of 47, wherein the imetelstat is imetelstat sodium.
[0264] 49. The use of 47, wherein the telomerase inhibitor is imetelstat and is administered for 1, 2, 3, 4, 5, 6, 7, 8 or more than 8 dosage cycles, each cycle comprising:
[0265] intravenous administration of about 7-10 mg/kg imetelstat once every three weeks;
[0266] intravenous administration of about 7-10 mg/kg imetelstat once weekly for three weeks;
[0267] intravenous administration of about 2.5-10 mg/kg imetelstat once every three weeks; or
[0268] intravenous administration of about 0.5-9.4 mg/kg imetelstat once every three weeks.
[0269] 50. The use of 49, wherein each dosage cycle comprises intravenous administration of about 7-10 mg/kg imetelstat once every three weeks.
[0270] 51. The use of 50, wherein each dosage cycle comprises intravenous administration of about 9.4 mg/kg imetelstat once every three weeks.
[0271] 52. The use of any one of 39-51, further comprising determining average relative telomere length by analyzing the relative length of telomeric nucleic acids in the cells present in the biological sample from the patient.
[0272] 53. The use of any one of 39-52, further comprising assessing hTERT expression level in a biological sample obtained from the patient after administration of the telomerase inhibitor.
[0273] 54. The use of 53, wherein the hTERT expression level is reduced by 50% or more relative to a baseline hTERT expression level prior to administration of the telomerase inhibitor.
[0274] 55. The use of any one of 53-54, further comprising altering the dosage of the telomerase inhibitor, the frequency of dosing, or the course of therapy administered to the subject.
[0275] 56. A method of selecting a patient most likely to benefit from treatment with a telomerase inhibitor comprising:
[0276] testing a patient for triple negative status, wherein the triple negative status comprises an absence of a mutation in each of the JAK2, CALR and MPL genes; and
[0277] selecting the patient if the patient has triple negative status,
[0278] wherein the selected patient is most likely to benefit from treatment with a telomerase inhibitor.
[0279] 57. The method of 56, wherein the patient has myelofibrosis.
[0280] 58. The method of 57, wherein the myelofibrosis is primary myelofibrosis.
[0281] 59. The method of 57, wherein the myelofibrosis is myelofibrosis that develops post-polycythemia vera (post-PV MF).
[0282] 60. The method of 57, wherein the myelofibrosis is myelofibrosis that develops post-essential thrombocythemia (post-ET MF).
[0283] 61. The method of any of 56 to 60, wherein the patient has not previously received JAK-inhibitor therapy.
[0284] 62. The method of any one of 56 to 60, wherein the patient:
[0285] has previously received JAK-inhibitor therapy;
[0286] has previously received and has failed JAK-inhibitor therapy; or
[0287] has previously received JAK-inhibitor therapy and has discontinued JAK-inhibitor therapy due to treatment-related to toxicities or intolerance.
[0288] 63. The method of any one of 56 to 60, wherein the patient has received JAK-inhibitor therapy and the patient was refractory to JAK-inhibitor therapy.
[0289] 64. The method of any one of 56 to 60, wherein the patient has received JAK-inhibitor therapy and is relapsed.
[0290] 65. The method of any one of 56 to 60, wherein the patient has received JAK-inhibitor therapy and discontinued JAK-inhibitor therapy due to treatment-related toxicities or intolerance.
[0291] 66. The method of any one of 56 to 65, further comprising administering the telomerase inhibitor to the patient.
[0292] 67. The method of 66, wherein the telomerase inhibitor is imetelstat.
[0293] 68. The method of 67, wherein the imetelstat is imetelstat sodium.
[0294] 69. The method of any one of 56-68, further comprising obtaining a sample that comprises DNA from the patient.
[0295] 70. The method of 69, wherein the sample comprises bone marrow, peripheral blood or a combination thereof.
[0296] 71. The method of 70, wherein the step of obtaining a sample from a patient comprises:
[0297] obtaining a bone marrow sample, a peripheral blood sample or a combination thereof; and
[0298] isolating DNA from the bone marrow sample, the peripheral blood sample or combination thereof.
[0299] 72. The method of 70, wherein the step of obtaining a sample from a patient comprises:
[0300] obtaining a bone marrow sample from the patient;
[0301] isolating cells from the bone marrow sample; and
[0302] extracting DNA from the isolated cells.
[0303] 73. The method of 70, wherein the step of obtaining a sample from a patient comprises:
[0304] obtaining a peripheral blood sample from the patient;
[0305] isolating cells from the peripheral blood sample; and
[0306] extracting DNA from the isolated cells.
[0307] 74. A method of selecting a patient most likely to benefit from treatment with a telomerase inhibitor comprising:
[0308] testing a patient to determine if the patient has an HMR, wherein having HMR comprises the presence of a mutation in at least one gene selected from the group consisting of ASXL1, EZH2, SRSF2, and IDH1/2; and
[0309] selecting the patient if the patient has an HMR,
[0310] wherein the selected patient is most likely to benefit from treatment with a telomerase inhibitor.
[0311] 75. The method of 74, wherein the patient has myelofibrosis.
[0312] 76. The method of 75, wherein the myelofibrosis is primary myelofibrosis.
[0313] 77. The method of 75, wherein the myelofibrosis is myelofibrosis that develops post-polycythemia vera (post-PV MF).
[0314] 78. The method of 75, wherein the myelofibrosis is myelofibrosis that develops post-essential thrombocythemia (post-ET MF).
[0315] 79. The method of any of 74 to 78, wherein the patient has not previously received JAK-inhibitor therapy.
[0316] 80. The method of any one of 74 to 78, wherein the patient:
[0317] has previously received JAK-inhibitor therapy;
[0318] has previously received and has failed JAK-inhibitor therapy; or
[0319] has previously received JAK-inhibitor therapy and has discontinued JAK-inhibitor therapy due to treatment-related to toxicities or intolerance.
[0320] 81. The method of any one of 74 to 78, wherein the patient has received JAK-inhibitor therapy and the patient was refractory to JAK-inhibitor therapy.
[0321] 82. The method of any one of 74 to 78, wherein the patient has received JAK-inhibitor therapy and is relapsed.
[0322] 83. The method of any one of 74 to 78, wherein the patient has received JAK-inhibitor therapy and discontinued JAK-inhibitor therapy due to treatment-related toxicities or intolerance.
[0323] 84. The method of any one of 74 to 83, further comprising administering the telomerase inhibitor to the patient.
[0324] 85. The method of 84, wherein the telomerase inhibitor is imetelstat.
[0325] 86. The method of 85, wherein the imetelstat is imetelstat sodium.
[0326] 87. The method of any one of 74-86, further comprising obtaining a sample that comprises DNA from the patient.
[0327] 88. The method of 87, wherein the sample comprises bone marrow, peripheral blood or a combination thereof.
[0328] 89. The method of 88, wherein the step of obtaining a sample from a patient comprises:
[0329] obtaining a bone marrow sample, a peripheral blood sample or a combination thereof and
[0330] isolating DNA from the bone marrow sample, the peripheral blood sample or combination thereof.
[0331] 90. The method of 88, wherein the step of obtaining a sample from a patient comprises:
[0332] obtaining a bone marrow sample from the patient;
[0333] isolating cells from the bone marrow sample; and
[0334] extracting DNA from the isolated cells.
[0335] 91. The method of 88, wherein the step of obtaining a sample from a patient comprises:
[0336] obtaining a peripheral blood sample from the patient;
[0337] isolating cells from the peripheral blood sample; and
[0338] extracting DNA from the isolated cells.
[0339] 92. A method of selecting a patient most likely to benefit from treatment with a telomerase inhibitor, the method comprising:
[0340] testing a patient for average relative telomere length, by analyzing the relative length of telomeric nucleic acids in target cells present in a biological sample from the patient; and
[0341] selecting the patient if the patient has average relative telomere length in target cells present in a biological sample from the patient that is determined to be in the 50th percentile or less of a relative telomere length range determined from one or more known standards, wherein the selected patient is most likely to benefit from treatment with a telomerase inhibitor.
[0342] 93. The method of 92, wherein the patient has myelofibrosis.
[0343] 94. The method of 93, wherein the myelofibrosis is primary myelofibrosis.
[0344] 95. The method of 93, wherein the myelofibrosis is myelofibrosis that develops post-polycythemia vera (post-PV MF).
[0345] 96. The method of 93, wherein the myelofibrosis is myelofibrosis that develops post-essential thrombocythemia (post-ET MF).
[0346] 97. The method of any of 92 to 96, wherein the patient has not previously received JAK-inhibitor therapy.
[0347] 98. The method of any one of 92 to 96, wherein the patient:
[0348] has previously received JAK-inhibitor therapy;
[0349] has previously received and has failed JAK-inhibitor therapy; or
[0350] has previously received JAK-inhibitor therapy and has discontinued JAK-inhibitor therapy due to treatment-related to toxicities or intolerance.
[0351] 99. The method of any one of 92 to 96, wherein the patient has received JAK-inhibitor therapy and the patient was refractory to JAK-inhibitor therapy.
[0352] 100. The method of any one of 92 to 96, wherein the patient has received JAK-inhibitor therapy and is relapsed.
[0353] 101. The method of any one of 92 to 96, wherein the patient has received JAK-inhibitor therapy and discontinued JAK-inhibitor therapy due to treatment-related toxicities or intolerance.
[0354] 102. The method of any one of 92 to 101, further comprising administering the telomerase inhibitor to the patient.
[0355] 103. The method of 102, wherein the telomerase inhibitor is imetelstat.
[0356] 104. The method of 103, wherein the imetelstat is imetelstat sodium.
[0357] 105. The method of any one of 92-104, further comprising obtaining a sample that comprises DNA from the patient.
[0358] 106. The method of 105, wherein the sample comprises bone marrow, peripheral blood or a combination thereof.
[0359] 107. The method of 106, wherein the step of obtaining a sample from a patient comprises:
[0360] obtaining a bone marrow sample, a peripheral blood sample or a combination thereof and
[0361] isolating DNA from the bone marrow sample, the peripheral blood sample or combination thereof.
[0362] 108. The method of 106, wherein the step of obtaining a sample from a patient comprises:
[0363] obtaining a bone marrow sample from the patient;
[0364] isolating cells from the bone marrow sample; and
[0365] extracting DNA from the isolated cells.
[0366] 109. The method of 106, wherein the step of obtaining a sample from a patient comprises:
[0367] obtaining a peripheral blood sample from the patient;
[0368] isolating cells from the peripheral blood sample; and
[0369] extracting DNA from the isolated cells.
[0370] 110. A method of monitoring therapeutic efficacy in a subject with myelofibrosis (MF), the method comprising:
[0371] measuring hTERT expression level in a biological sample obtained from the patient after administration of a telomerase inhibitor; and
[0372] comparing the hTERT expression level in the biological sample to a baseline hTERT expression level prior to administration of the telomerase inhibitor;
[0373] wherein a 50% or greater reduction in hTERT expression level in the biological sample identifies a subject who has an increased likelihood of benefiting from treatment with the telomerase inhibitor.
[0374] 111. The method of 110, wherein the hTERT expression level measured or assessed is hTERT RNA expression level.
[0375] 112. A method of identifying a patient with myelofibrosis (MF) for treatment with a telomerase inhibitor, the method comprising:
[0376] measuring hTERT expression level in a biological sample obtained from the patient after administration of a telomerase inhibitor; and
[0377] comparing the hTERT expression level in the biological sample to a baseline hTERT expression level prior to administration of the telomerase inhibitor;
[0378] wherein a reduction in hTERT expression level in the biological sample identifies a patient who has an increased likelihood of benefiting from treatment with the telomerase inhibitor.
[0379] 113. The method of 112, wherein the reduction in hTERT expression level is 50% or more.
[0380] Although the particular embodiments have been described in some detail by way of illustration and example for purposes of clarity of understanding, it is readily apparent in light of the teachings of this invention that certain changes and modifications may be made thereto without departing from the spirit or scope of the appended claims.
[0381] Accordingly, the preceding merely illustrates the principles of the invention. Various arrangements may be devised which, although not explicitly described or shown herein, embody the principles of the invention and are included within its spirit and scope. Furthermore, all examples and conditional language recited herein are principally intended to aid the reader in understanding the principles of the invention and the concepts contributed by the inventors to furthering the art,and are to be construed as being without limitation to such specifically recited examples and conditions. Moreover, all statements herein reciting principles, aspects, and embodiments of the invention as well as specific examples thereof, are intended to encompass both structural and functional equivalents thereof. Additionally, it is intended that such equivalents include both currently known equivalents and equivalents developed in the future, i.e., any elements developed that perform the same function, regardless of structure. The scope of the present invention, therefore, is not intended to be limited to the exemplary embodiments shown and described herein. Rather, the scope and spirit of present invention is embodied by the appended claims.
Sequence CWU
1
1
9113DNAArtificial sequencesynthetic sequence 1tagggttaga caa
132142939DNAArtificial
sequencesynthetic sequence 2ctgcaggaag gagagaggaa gaggagcaga agggggcagc
agcggacgcc gctaacggcc 60tccctcggcg ctgacaggct gggccggcgc ccggctcgct
tgggtgttcg cgtcgccact 120tcggcttctc ggccggtcgg gcccctcggc ccgggcttgc
ggcgcgcgtc ggggctgagg 180gctgctgcgg cgcagggaga ggcctggtcc tcgctgccga
gggatgtgag tgggagctga 240gcccacactg gagggccccc gagggcccag cctggaggtc
gttcagagcc gtgcccgtcc 300cggggcttcg cagaccttga cccgccgggt aggagccgcc
cctgcgggct cgagggcgcg 360ctctggtcgc ccgatctgtg tagccggtgg gtgttatctc
tgcctggctt ctgggtgggg 420ggcagcagct gtctctccac ccccttccta ccttttggtc
ccgcctgccc cctgctagtg 480gcagcaaact tctgagccag aaaaatcttc ctctttaaga
cgacacctag aacgagtctt 540gctggtgata tttgcttcca tttgtgtctt ataattccct
cgctcccgcc tccttattcc 600tttttaaaat tttctagaca cttaaacagc ctagaaaaag
catttgtttc ccctggattt 660atgtggtagt agttaactgc tgcttctgtt tttaggtttc
agaagcaggc aacaggaaca 720agatgtgaac tgtttctctt ctgcagaaaa agaggctctt
cctcctcctc ccgcgacggt 780gggtgtgctg tcctttatcg ctgcagtaaa ggcgaaggtg
tctggagctg ggagtgcgtg 840cgtagggaag gttggaagcg tgtgaagaga ggcagggctc
attgttgctt actcttctga 900aaatgtcagt gctaaacttt taatgttgat ctgggagagt
aattttgggg tgttttgttg 960ttcgtcttgg atcctttaag aaacattttt ttgttggctt
tacacataac gtgactttgc 1020agagaaacga aaaacgttgt ccattaccct ttcttcttaa
gcagccagag attcttaatc 1080ctttaaagag gagtatttcc aagcaataag agatagcttt
tgggagaaca cgttagctat 1140tcttgctggg gtttctgcta ccacattgaa tgtttcctca
tggttttatc tgcctaagct 1200tgctgtgtcg gttgaattta cccagtttgt tttccagtaa
ttactaatct gttaggagaa 1260actccatttc tctgaatgaa agggtaggag cggctgagta
tggagaagga aactggaagt 1320gggaataagg gaaatgattg cttttggttt cataataagt
ttgtacagtg agttgttggg 1380ctactgcaaa taaagatttt gtatcccttc tccagaatgc
ttgggaccaa aagtgttttg 1440gatttttttt aaaaattttg gaatgtttgc atatacaaaa
tcagacatct tgaggatggg 1500acccaagtgt aaatacgaaa ttcgtttgtt tcatatagac
cttattcaca cagccactaa 1560gtcatttgca atatttttaa tacgtctgtg catgaaacaa
agtttgtatt aagtacctat 1620gcggggaatt ttccccttgt agcatcatgt tggtgctcaa
aatgtttcag attttgcagc 1680ttttcagata agggatgatc agcttgtatt ttgatataac
acccagaaca tttgaagatg 1740aataatcaat ttttggcctc ccttccccca tccgcctcac
cttataccac tttaagtgtg 1800agaattattt gcttgtacat gcatttgtct gttggtgtgt
aacgtatgta cagactggat 1860gtatccagca cttgccttaa tagtacatgt atttacctga
ataggaaagc tgcagtactt 1920gctggccaga agagcacacc atgcttgttt ttgctctaac
tgaatatcct gtatttgcaa 1980tttatagcag ttttagggac tcattaggga attttgtgtg
tgtgtgcctt tggtgatttg 2040agacaggtgt ctcagatatg ggaagggaat atgacattgt
ttctctttca cctggctatt 2100actgaaaggt gggatgcttt tgaggcagaa taggaaagtg
cattggcttt ggagtgagat 2160ctggatttga atcctggtgt tcttgccact taagagttgc
attatttacg gctggtcatg 2220gtggctcacg cctgtaatcc cagcactttg ggaggctgag
gaaggaggat cacttgaggt 2280gaggagcttg agaccagcct ggccaacatg gtgaaacccc
atctctacta aaaatacaaa 2340aattagccgg gcgtggtggt gcacacctgt aatcccagct
actcgggagg gtgaggcagg 2400agaattgctt gaacctggga agtggtggtt gcagtgagcc
gagatctcac cactgcactc 2460caggctgggc aacacagcaa gactctgtct aaaaaaaaaa
aaaaaaagaa agaaaaaaag 2520agttatatta tttacgactc ttttagcttc actttcttat
aagattgttg tgagaagtga 2580gtaagacaca tgcaaagtgg taaactgcct ggctgtcata
aaagtcttgg ctactatcac 2640ggctgggagg caaaggagat tcagagaagg gcagaatgac
tgcataaggt gatctgcctg 2700taactcgtgt ttcctccttt ctagtataaa gagataaagg
acttcaaggt cttaaactgg 2760tgagggagta ttacagcctt tgtatggaaa ggtttgactt
tgtgtctctg cttaaacccc 2820cattgtgttg cccctaccaa ttattgtgct gcccccttgt
ggttaactgt gctaagacct 2880ttcttttgct cttctcccat tacatttccc acccttcccc
actccctttt agacccctcc 2940tcttagctcc cagtttccca aactgtgtgc caaggtgccc
agagcacctc aggcttgaac 3000ttgtgttttg agttggttca tggtttcaat attagatacc
tacacccgtt tctacaatgt 3060catgtctttg taaagatgta ttttcagagg ttgctccgat
aaaaagcaac tactacatga 3120aaatgaatgt agaacaggaa atgacagtgt ggtattgtcc
aatttgattc taaggtttga 3180taagttctac agtgctctac actaagttgt aaggacataa
ctactaagta agttgttcaa 3240acctatttct tttggcctgg gggtgtcgtg aaaaatttgc
taagactcag agctccctga 3300atgggtttgg aaacctctgc cttagctttt agtttgcttt
tctgataaaa ttattgatat 3360aaagctagta ccagctgatc atggcttaat atatttcctc
tcctatgtaa tatgtttata 3420acttctgccc agttctttca ttttaaaact aatcctattg
ctaacttgtt gtactagtca 3480cttcctggtt tttcctgtac tggtcttctg cttctacttc
tgttcatctc cttaaactcc 3540gaatgcccca agtgaaagtt accattttct accccttaat
tttcttctaa tcatgtaggc 3600tttaaattag gcatcatctt taaactactt ctttcattta
cctcttattc ccattcaaaa 3660tgtccatatt tcctttcttt ctcatatctc tgctttccct
cctttactgt gtgaatccca 3720ggacacattt cctgagccta gaatattgaa agtcatttga
acttctgaga attcagtgtc 3780ccttccttct gtttatcctc aatagagatt ccactctaat
actccttatt atagcattcc 3840cttgccccaa aaccttcagt ggcttaccat tttctactta
ttaaattttc ctgactttta 3900agatagtcta ttatcaatcc ctgccctatt tatttagtct
tttgtctaag gatctctagt 3960ccttaagctt gtaagctgat ttccacactt tctaataata
agctatgctt cttctatcct 4020ttaatttttg cccatgttct ccatccctct tttttttcct
ctatttctgt agctctttag 4080tcttagaaca ttttcacatg gtttaattat atgccatgct
ttagttgttt gatagttatt 4140tccctagtgt tagccatatc ttttcaagtt gattgtgtat
tctttgagga gcagtacctt 4200agattaaaaa aaaaccacaa cacacagtgg agagcacatg
ggcagcattc aagaaataca 4260tgttgattgt gtgataagga actgtagtca ccaaacaaat
atttgttaat acttgcaatg 4320taaaaggtac ttggctgtat tcaaaagaga aataaagaaa
tataaaatag gctcctttcc 4380ctaaggactt acagtataat tgggcagata agctaaataa
taaaagttac agatatttaa 4440gaccacttga gttgagcaga gattttgcat aataggaagg
aactggtaga gggggtaagc 4500aaaggcaaaa tatgtatata tgtatgatat gttcagagag
cagtacataa ataacttgac 4560tgaaatgaag atttgtgtga aagagtagta agaaattgtg
ttaaaaatgt agttggaatt 4620tgattatgga tgtctttaaa tgctaggatg agaagaatgt
actttgacct gtagatatgg 4680agaagcttta aaagttttga attgagaaag agtttgctga
aataagtatt ttaggaaaat 4740caaagcagca ccagtgctag gtctcatatg aattggaaag
agaatggtag aaagaggtag 4800gaaaataatt gagccctgaa gtaatgagga cttagaaata
agtcagattg cagagatgtc 4860acaagacatt attatggatt ggataagaag ggagaatgga
ggggagaaga gtgattaaag 4920attaccttac cttgaaggtt tgcttttcag tgacggagga
aatcaaagag tgttgactct 4980ccaagacatc ttagaacatc taagtctata tgttttgtat
attaggactc agaccagaga 5040gatttaaaaa tgtgtccaaa gttactcagc tagttaatga
caaagaaact gccgtttgat 5100taatggcagt tactaacaaa aatagttatg gcagtgttag
tagctggtag aggggatgta 5160gacagttgag cgtatattgt ggatatgttg agtttgcggt
ggccgtggga tgggcaagtg 5220aaaattgata gcatacagtg ggacatatga ctagaatttg
ttagcgaagt taaggctggt 5280gctgtggtac ttaagagaaa agagtgggat tgcccataat
tagcgggtgg gtgaaaggag 5340aggaatgggt aaaggagaca aagaaaaaaa cagtatgaga
ggcaaattag tggataggtt 5400aggaggcgga atgatcaaca tgttgatcat tggcaagaaa
tgagaagaat cagatccaaa 5460aaaaggtctt aaaaagatgt attcgtgttt ttcctaataa
gaaatctata aaaacagaag 5520aaaattgctt atactttccc tacgtggaaa taaccactgt
taatattttg ttctctccgg 5580tttaacaaaa gacctttgga tttgacagtt gggtgatcag
tggagacttt tccaaagctc 5640tccatcacta ggactaagga tgagaatttt aggcataata
aaacctagga gatatttttc 5700aacagattgt cattcgtctg tatcgtctta tatatcacac
tgtccaggta ctattcttcc 5760tgtgtgcatt ggttctgtgt ttttttctga atgatagaag
gttagacaag ccatctctgg 5820gtgcttttgt gctggtaaaa tttgaataaa gtgataaaat
atttgtttct aaaaggaagg 5880agaaattctt ggtcgataac ttataaatct gagggttgaa
tgattgatga aattaggggt 5940actggaaaga acaaagagaa gcattattta ttttgaagct
tttctgtata gttacaaagg 6000gttaactagg ttagaatggt ccatgggctg tttactttgc
ttgcatgttt attttgatct 6060tcccaagaac attcttctgt tcatcttttt agtatgttat
tggaaacaga gtactcatta 6120gttcttacta agtggtttta gtttaataaa ttatgattat
gaaataaaat gctattaggt 6180aatattttta taatataaag ggccatgtga tgtgagtaag
tgcactgttt tggaaatcag 6240gggataaggg actgaccctg ctctcagcat ggtatatgat
ttcaggcaac tcacgtaatc 6300agtgagtctt gtctattgag ggaatggact aaatcttttc
tagaaaattt aaaaaggtgg 6360gatcacatgg taaaatgtgt ataaagttta aaaaggaaat
ggtttaccaa tgtttatgac 6420aaaaaccagc aaactctttc ccaccccccc accccacatc
tccttttcta gtctctaatt 6480cctgtacacc aggcaaccac ctgtcctctg tactttgccg
ttttcacctt tataatgaat 6540gaattgttta gcatcccctc taaagcctct ccattcagtt
gtgtagaaga gctcatcccc 6600tttgccttca agggctttac cattatattt ctctcctctt
tttcttgcct tctcaattct 6660tccctctact ggattatttc catcagcatt actctgattg
ctattgctgt gtaacagaaa 6720ctacccaaaa cttagtgatt taaaacaact actttattag
gctcacagat accatgggtc 6780agtaattgag acagggcaca ccagggatga ctttgttttt
gctccacaat ggctactagg 6840acatgagttg ggaagaattg ccagccaggg gtgacttgaa
ggcaaaggac tggaatcatc 6900tggaggtgtc ttcactcaca tgatgggtag ttgatgctgg
ctcttgactg ggatgttagc 6960tgggctgtta actggagcat gtacatgtgg cctggatttc
ctcacaatat ggtggcttca 7020gggtggtcac ctttcatagt ggtgagtaga gaattaaaag
tgagtgtgtc tcagcataaa 7080tcttttatga tttagccttg gtagctgcac agtataactt
ctgccatgtc ctactggttg 7140taagggtcag aagcctgtcc agatttgatg ggggagtggc
aagttcacac tgcagaagaa 7200aaacatgtga gatgggaaat agtgttatgg ccatctttgg
acaattatta atactattgc 7260catagtttgc cattttgcca aacttcacat ccctcctgta
tctgaaatac acgcaaaata 7320cactgagctt ctcctcaaag gtccctaatt cacatcccat
catgacagta actcagagtc 7380cagtatctca tcatataaat caggtccagg tacagaatag
ttttcttggg tatggttaat 7440tggatatggt tcttcttgaa ctgaggaccc atgaagagac
agtttatatg tcccctgcat 7500actttacaaa atggaaaagg cacaggttat ctgcagtaga
cattcctcct caagaagcat 7560gcaaggtagg cacagtctgt agcaattctg caacctcact
gggcacatgt tgccagttcc 7620ttgattaggt ctcagtcctg cttcctggaa gtcattctta
ataggacata ggcttcttct 7680gtttttgggt ttaccttctg aattatttat ctcccccacc
cctgcaccca acccatataa 7740attgctttgt atttgtaaga gtagctttct gagcttgctt
cctgcctgta gtgctccaga 7800gtccaaaggc ccccttttat atagcaactg tccctttcat
tccaagctaa tacaactcct 7860ttaaaaactt tgtggacttc ctgtgtgtaa gtttataatc
tgtactgcca tacccacaaa 7920tctcttttga gaggaactct ttcctcccct aagctctgtg
tgagtctgct gtgggacaac 7980acccttaaga tccttagata atatttcgtc tgaaaggatc
tatgaggtac tgatttagat 8040cttaagaaag gatcttataa tcacactcta gattggatct
ttgctctgag gcccttttta 8100tttgacactt tgctggctga aaagattgtt ctgagtccat
tacatctcct tgaaattcta 8160ctcaaaaaat gaatagctta ttctttagtt catctctctg
ttctctcaat tataagggca 8220gctagaagaa gccaaattgc tttaacttcc tgctgagaat
ctccttaatt cattaggtca 8280ggtatgtatt ttattttcca tgttaatgta ggtgacagtt
ttgctaaact ttgccctagt 8340atgtaacaag ggtgtcctct tattcagctt tcactatcat
ttctctcact ttgcttgaag 8400tcctcactga cagtctcctt gagggctctt aggctcccat
gaagtttcct caagaccctt 8460tacatgtgtg aacacaaagg gtccttatct gttcctggct
atatagcagg tccttgaata 8520actgtcattt cttcataacg ttgataagaa aaaaatggat
tcctggctgg ggccactgtt 8580tgtgtggagt ttggacattc tccccacgtc tgtgtgggtt
tttccgggtg ctccaatttc 8640ctcccacatt ccaaagatgc atatgttagt ggatcggtgt
gtctaaatgg tctcagactg 8700agtgatcatg tatggatgag tgtgccttgc agtgggtgat
gtcctgtcta gggttggttc 8760ccaccttgtg ccttgagttg ctaggatagg ctctagccac
tcgtgactga actgaattgg 8820gttaataatt atcctacttg tttttattag tctttcttaa
atgtgtgtat agctcacatt 8880tatttcagtg tttaataatc agagtgtttg gaatctttac
ttagaagttt gatgatgttt 8940ttgtggccat aaatatgcca taggaacttc cttatctcaa
ttagcctatg gaaaaatgga 9000ttttgttaca cattgtttca cttaaagtca cagtttccaa
gaacctattg aagacagtga 9060ggattaactg tactagaact gtttcctaac ccactggttc
ttatcagaat tacctaaagg 9120acttattgaa acacaaattg ccgctgggcc ccacccccag
agtttgtttc attagctctg 9180gagtgggact tgaggatttg catctgtgag ttcccaggtg
atctgataat gttgatctgg 9240ggcctagatt gtgagaatta ctgatttaaa ccagggattg
gcaagatttt tctattaagg 9300atcataaata aaatatttta gactttgtgg gcaagattgt
ttctcttgca cctactcaat 9360tccgcctttg tggtgcaaaa gcagttatag acaatacgta
aatgaacaga cgtggctcat 9420ggctgtgttc tcataaagct ttatttacat aacaggcagc
tggctaaatt tggtatgtgt 9480gaactgtgct ctgccaattc ccaatttaaa tcattacttg
actccacatc tcttcaagct 9540atggccccat ttttcactcc cctttggaac aaaactctct
gagagttgtc tgtatttgtc 9600tctttttatt ctttcataaa aaaattatct attttttgaa
cacatttaaa tgtcttagaa 9660ttcaaaaagt agtaaatatc tttgtacatt tgtcagggcg
tgtgtgtgtg tgtgactata 9720actaaagatt aagtagaaga ggagttgctg attcaaaagt
ggtatatgtt actaagttca 9780acaaatattg ccaaattgac atagaaatac caagttatgc
ttttctacac ctttactaac 9840attgtgtttt cagatgactt gattgttgcc aacttgagac
gtgaaaaata gaatctcatt 9900ataattttaa tttgcttttt attctccttt tttagggaac
tcttcactca tatcttggcc 9960cactttctat tggatttgtg gtccttttac tttgctttgt
gggagctctt atactaagga 10020agatagcttt gagtttgcga aatgagttgt tttccctagg
ttgtctcttt atctttttga 10080ttctgtagat agtgtgattt tgttgttgtg catctaggta
ggttccttct aaccctgaaa 10140ttatattttg agattctccc ttgttttctt gttccatctg
gaatttatac tgatgcaaga 10200tataagatgg gacgcaactt ttttccccta gatggttgtc
cagtttcaat actatttgtc 10260agataatcct tcttttctct gctgctgtga aatgctggtg
ttttaaattg tgtatgtagt 10320tggatctatt tctggacttt gtttcattct aaaaatggct
cctctgaaac catattgtga 10380gttcttgggt agtgaacatt tctatttatt tgtttccaag
tcctgtataa tatttattag 10440catatgggag gcattcaagt acttgaaaat aaaatgaata
aatcaagcat ttaggaatag 10500aagcagatct ttttgccaat tattcatttt agttattcta
tttaattctc tatttctgat 10560tttaaacttg aatttaacct tggttttcca ttttagtttt
accttttttt taaactttat 10620tgtgaagtat taagttattt tttgtactta ctgaatgggc
atttgctaac ttatgtgtct 10680gctcttatta gtctattttt ggcctcaaat tgttaaaaat
tcacagtata gttttatttg 10740tatcaaattt gctactgagg gaagcttgtc atttcataat
ggcaatccat aggataggtc 10800aagtcatttg agattggaac cattaaggat aagttcattt
aacattgaat tattagatct 10860gtggttaatt ggccaggtta gagaagacag aattacaggg
aagtctggat tttacaactt 10920attattttag agggtcaaat ttagaataat atttttaagc
tttttaagta gaagtatatg 10980gatcacctga ggtcaggagt tcaccaccag cctgactaac
atggtgaaac cctgtctcta 11040ctaaatacaa aaaaatagcc aggtgtggtg gtgcatgcct
gtaatctgag ctacttggga 11100ggctgagaca ggagaatcgc ttgtacctgg gaggcagagg
ttgcagtgag ctgagatcgt 11160gccattgcac tctagcctgg gcaacaagag tgaaactctg
tctcaaaaaa taaataaata 11220aataaataaa aataaataca taaatagaag tatactattc
tgattctctt atttatatgt 11280ataatttatt tttttaaata catgaggtat tgtagatttt
ttggtttttt tgaggagggg 11340cgggggtgat gtgaaatata gttttcattg catcagatct
tcagttgtaa tgatattgct 11400ggaatccacc atttaggacc ctgtcttgtt aaaaaaaaat
tatccttgcc ttcaccccta 11460cccctccctg ccacagactt ttaaaggtaa gtattctgcg
ataattggat tatatttact 11520attatgaaaa tttaaaatta ttagaagtaa aatgaaatat
acctccattg tagtaagttt 11580gattcacagt gcctctggtt atggtggtca gtaaaagtaa
cactgtatta ggaacagtct 11640tcatggtggg agttctctcc ttttactctt ctgttagttt
gttctttttt tttttttttt 11700tttttgagat ggtttcactg tcactcaggc tggaggacag
tggctcgatc acggctcact 11760gcagccttgc cttccctggg gtccagtgat cctcctacct
cagcctcctg agtagctggc 11820actgcaggcg agtgccacta ggcctggcta atttttatat
ttttttttgt agagatgggg 11880tttcaccgtg tcactcagtc tggtcttgaa ctcctgggct
ccagcaatct ttctgcatca 11940gcctcccaaa gtgctgggat tatggttctg gagccaccgc
gcatggcctg ttagtctgtt 12000cttgcattgc tataaagaaa tacctgaggc tgagtaattt
ataaagaaaa gagatttaat 12060tggctcatgg ttctgcaggc ttacaagcat ggggctgaca
tttgctcagc ttctggggag 12120tcctccggga gcttttactc atggtcaaaa gctaagaggg
agcaggaata tcacatttca 12180agagctggag caaaagagaa tgtggggaag gtgcacacac
ttttaaacag ccaaatcttg 12240caagaactca gtatcttcag gacagcacca agggggatgt
tgctaaacca ttcatgagaa 12300atccaccccc atgatcaagt cacctcccac caggcctcac
ctccaacatt ggggattaca 12360gtgcaacaca tgaaatttaa aggggacaac atccaaactg
tatcaacctt gctgtacccc 12420tcagcctcat tttataggca acaattgaat atattggttt
tataaaggtt tgatatggaa 12480agattcatta ggagtggatt ttaggacttg gggaatgact
cagagaagaa aatagtgcat 12540gatagtataa gtctatctga ttgatgagta actggaaatc
cttccaaaac ataatgcttc 12600agtgtctgca gaattgtttc atttccatgt ttatgtattt
cttattgttt ccttgtttat 12660ccataggtgc ttaatttttt tttaatctga atgcattatg
ataatcttta aataattatt 12720tcagaggaat atctgaaata ttcagtgttc ttctagcatg
gcagtatttt aaaaatcatt 12780atgagcttaa attcatactg atttaaacaa cttctagatt
tttttgaata tcaatagcag 12840agggtagttt taaatatttc acgagcagaa ttaattaaat
ttcctgtgca attttatttt 12900ttatagacaa actcgtcact tcttaaaatc ttttaaaaat
gtcttggtaa tacaggcttg 12960gaatatgatg gtattgaaat gagatcttaa gggaaaaaaa
actccaacgg gtttttttgt 13020tgttgttgtt gagatggagt cttgctctgt cacccaggct
ggagtgcagt ggcattatct 13080cagctcactg caacttctgc ctcccagatt caagcaattc
tcctacctca gcctcccgag 13140taactgggat tataggcgcg caccaccacg cccagctaat
ttttgtattt ttagtagaga 13200cggggtttca ccatgttggt caggctggtc tcgaactcct
gacctcgtga tccgcccgcc 13260ttggcctccc aaagtgctgg gattacaggc atgagccacc
atgcccggcc aaaaactcca 13320acttttagag gcctatttac agcacttgtc ccatatttgt
tcacactttt tctgtatgtg 13380tgttgtgaat tataaatctg gcttttccta caaatgtggc
ttttcctgtg tagtcatcat 13440taagcatgat tctaagaagt agctcaaaat ctcctaagac
caaaaaccac aaaaaacaaa 13500aaaaaaaaca acaaaaaacc aaaaccagaa aagggataca
ttttgcagaa taatttatat 13560tttcttctct tcatggcatc agttttctca ggagttcttt
ttttgagatg gagtctccct 13620ctgtcaccca ggctgtagtg cagtggtgcg atctgcaagc
tccgcctccc gggttcacgc 13680cattctcctg cctcagcctc cggagtagct gggactacag
gtgcccgcca ccacgcccgg 13740ctattttttt ttttgtattt tcagtagaga cggggtttca
ccgtgttagc caggatggtc 13800tcgatctcct gaccttgtga tccacctgcc tcggcctccc
aaagtgctgg gattacaggc 13860gtgagccacc gcacccgggc tcaggaggtc ttttaagctt
ttgcctgtca tgtgtgtact 13920tctgacgctg gcccaaggta aaatgattac atttgacttc
ggtagccctt aaatgtatgg 13980ctgttcttaa tcttttctaa agcctaaaag ttgaattagt
attcatctta gatttcttgt 14040ttcttaagtg aaagaatcat gacattgtat taaaatatct
tatttgcatg tattttatat 14100actgttttaa taggcagtag tagtatacaa gctttgacca
aatgtctctt catataaaaa 14160attcaagtga ataaaaacag tcatttaaaa atgacattag
tcaaaggggc aaaaaagatt 14220acaaatgctt attgtgattg acagaacttg cttaacatat
tagggttctc tagaaggaca 14280gaactaatag gatatatata tgagtttatt aaatattaac
ttaaatgatc acaaggtccc 14340acaataggct gtctgcaagc ttgaggagca aggagagcca
gttcaagtct caaaactgaa 14400gaacttggag tctgatgttc aagggcagga agcgtcttgg
ctaatccacc catcttggcc 14460tcccaaagtg ctaggattac aggcgtgagc ccccgtgcct
ggtgtacatc atttttaata 14520tctttatagt attctgttgg ctaagttgcc acaatttatc
agaccccttt aatgtcatta 14580attttttccc aatatttaga cttgtttcat agaattatta
gatatgcatg ctactactcc 14640tgtccttttt caaaggacaa ttattagata ttcttgtttt
cctcatatct ttgccaacac 14700tgggtattgg cattcttctt gtttaccagt cagctaagga
agctaaggaa gaaacaatat 14760ctcattttta tgtacttttc tctgattctt aattatgttg
accatgtttt catttctttt 14820gtgaaatgcc tatttatgtt cattttcata ttaaattgta
agagttactt gtataaatat 14880attaaacctt tgtagtatat attttttctg ttttttttta
aagttttgat tatagtgttt 14940ataatatgca gtcaaattta cccatctttt atttcctcta
tcatttttca cttagatgtg 15000gggtttagaa aggaggtaca taatgtgaca gagtttttgg
tatagaaata actgacatag 15060ttagatataa aacataccaa ggaaatagtc ggaaatgtcc
aatttcgaat gtgtaaggag 15120accagtaaga aaatcatgaa gaacagctaa cagcagtaat
ttttaaaagg gtatttacaa 15180acacttgaaa atgtttatgt agtttaaagg aatgattcaa
atataaagag aagcgtaaca 15240taaaaatgaa ataaaggcat atatatagtc attgtgtaga
tggttttcta gtaacagtta 15300taccaagttt gaaatgattt ttaggctttg ttatgccaac
ttttaggagt tttcttttta 15360aactttttga gcttatgttt catcatggcc aatttttata
aattttccct atatgctcaa 15420aacatttttt tagtggaagg ttttaatacg tctgtaattt
ctccggtgtc ttaaaaataa 15480ttagtttgtg gagctctttg tgtattggag ataccatctt
cttgtttgat atatttgtat 15540atgtattaag taagaactgg ataaagaagg tggttgggat
atgtataaat atcaggtaag 15600aacttgataa cgtattggtt ggtttgcata tgaaaagttg
ccctcactgt caggttcttt 15660cctgtttcta ggaattggct agccctggaa ggactgcccc
ttccagggtc agcaaattcc 15720caagatagca aagcatcaaa aatacagaat aaaaagacat
gcttagtaga gtatatagaa 15780atacaattgg ttttgtttat tttgtgatgt atcctgtgat
actggtaaat tcatttataa 15840gttctagtaa ttttttggta gaatcctcag catttttgat
aaatacaatc atgtctgcaa 15900ataaaaagtt ttatttcttt catttcaatc tctatgtctt
ttatttcatt ttcttaccag 15960attgcattag gtagaacctc cagtgttgaa tagaaatggt
ggtggtgagc atcctttcct 16020tgttcctgat tttatggaga aagcattcaa tatgtaatca
ttaagtaata gaaggttgtt 16080tgtagatgat ctttatttta ttgaggaaat tcccttcttt
ttctaattta tttccagaaa 16140ttttatcatg aattggtgtt gacttttgtc aaatgctttt
cctgcaacaa ttgggacgat 16200cttatggttt tgctccatta ttctgttaat gaggtaaatt
gcattgattc attttcaaat 16260gtcaaagcaa ccagtatgac tggaataaaa cccacttggt
gatggtgttc tgaccttttt 16320atatgctcct ggttctatgt tctattattt tgttatgttc
atgagaaaca tttgcctgta 16380attttttttt ttttttatga tgtgtttttg ccaggttttg
gtattaggat aattctggcc 16440acataaaatg atttggaaat tatttctgcc cctctgtttt
ctgtaagagt ttatacagaa 16500ttggtactat tttttcctta aatagttgac agactttccc
agggaagtca ctttggccaa 16560gagttttctt tgtgggtatg tttttaatga agaattcaat
ttattgaaga gatatgatac 16620tattcaaggt ttctgtttct tcctatgtca gttttggtaa
tttttgtctt tcaaggaatt 16680tgttcatcaa atctaacttg ttaaagtcat tggcatgaag
ttgctcctat ctttttatat 16740ccacttactg tttataaaat ctgtagcgat atcctgcttt
ttttacatca tatggggcac 16800atattggtaa tatgtgttct tttctgtttg taaattgatc
atcttagagg tttatcaact 16860ttttaaatct tttctaaaaa caaagttttg gtttgattga
ttttctttat tgttttatat 16920attattaatt tttgttcttt attctttctt cactctctgg
ttttgttttc tagctaccta 16980ggaagcttac ataattaatt tcatatcttt cttcttttcc
atcataagca tttatagcta 17040tacattctct ctaaccacta ttttagctgt attcccccaa
attttattgt ttattatcat 17100tcaggtgaaa ataatttctg atttcccttt taatttcttc
ttcgaacctg ggattattta 17160gaactatgtt aattttgcaa tactgggaga ttttctagat
agttttttga tatttatttc 17220taattcaatt ttgctatggc caagaatata attcatatta
attcagtctt ttcaaatgtt 17280tgagaattgg tttatggacc aacctatggt ataacttagt
gaatgttctg tgagcacttg 17340aaaaggatgt atgttctgca gttgttgggc attgtgttct
gtaaatgtca gttatattta 17400gttggttgat gtttaggtct tcattatttt tactgattaa
aaaaattttt tttgttaatt 17460cctgagaaat gagtattgaa atttttagtg taatagttgt
tttatttccc tctttacatt 17520tttgcttcat gtaattggaa actattattg tgtgcatata
tatttaagaa gagtaattta 17580taaatcttct atgattagtg tttttatgtt ctgcttacaa
gaggtcacat tggtctgttt 17640tccatcttaa attaatattt gtgtaccgta tgaagtagat
agaagttaag gttatttttt 17700gccccatatg aataaccagt tgactaagcc acatgttttg
aaatgaccaa tatttcttca 17760ctgaaatgca atggcacatc tgttccaaat taggtaactg
tatgtgagta tgtttttttg 17820gactctattc tgttccattt gtctatttgt tcatttttgt
gctaatacca atctgcttgt 17880tctatcttta tgataaatct tgatgtctga taatataaat
ctttagtttg ctcttcaaga 17940ttgttttggc tattgtaaat cctttgtttt tcacagactt
taggatcaac ttgtaaattt 18000ccacaaaaac tgctaggatt ttaattggaa gtgggttgaa
tctatagatt aatttggaaa 18060agaaccgaca tctgaaccat actgagtttt tctgtattct
tatatcagca tggtctatcc 18120ctctcttatt tagctagcat ttattttttg tagaaatgtt
ttacagtttt tattgcacag 18180tttttacaga tatttccata gatgtattcc taggtatttg
attttttgtt actattgtaa 18240atgatactat ttttaaatgt tcatttaaaa aattgtttgc
ttctgacata cagaaatgca 18300gttgattttt atatattggt cttgcatctt gtgactttgc
taaattcact cagtgattgg 18360tagattcttt taaatttcct acatatacag acatgtcctc
tatgaatact gacaatttta 18420cttatccttt ctaatcatca taacttttat ttagttttct
tgccttattg cactagccac 18480aatgtccact atggtattga atagaaatca tgattttaga
catgattgtt acgtttttga 18540actctagaag aacaagatca atattttacc attaggtata
ttgttttttt actgttaccc 18600tttatcagag tgaggaagtt tgcttttatt cctagtttga
gattttaaaa tcatgaacat 18660tggttaaatt ttattaggag tagtttctgc atctattgaa
atgatcatat ggtgtgtttt 18720ctcattgtgc taataatgta aaatatattg actatttaaa
aaattttttt ctaaattaca 18780taaaaattgt atatatggtg tacaacatga cattttgtta
tatgtataca ttgcagaatg 18840gcaaaatcag tctaattaac atatgtatca cctcacatac
ttatcttttg tggtgagaac 18900acttaaaatc tactcttagc aattttcaag tatacgatat
attgttattg gtaatcacca 18960tgatgtacaa tagatctctt cagtttactc ctcctatcta
acagaaattt cgtatccttt 19020gaccaacgtc tcccattcct cctaatggga ccctcagcct
ctggtaactg ctgttctact 19080tactctctgc ttctatgatt tctacttttt tagattctat
ggatcagtga gatcatacag 19140ttttgtcttt ctgtgcctag ctttatttca cttaatataa
tgtcttccag gttcatccat 19200gttgttgtaa atgacaagat tttcttcttt ttttaaggct
gaattatatt ctattgtgta 19260catatgctgt attttcttta tcagttcatc tgttgatgga
cacttaggtt gattctttat 19320cttggctatt aagaataatg ctgcaatgag catgggagtg
tagatattgc tttgacatat 19380tatttttagt tccaataccc agaagtggga ttgctaaatc
atatggtagt tccattttaa 19440ttttttgagg aacctccatt cattttccat agtgactgta
aaaatttaca ttttcccacc 19500aagagtatac aagagtttct ttttctccac acactcacca
atgcttgtta tccttatatc 19560tttttgataa ggctcattgt aacaggcatg aggtgagatc
tcactatggt tttaatttgc 19620atttagtgat gttgaacgtt ttttcatgaa catgttggcc
atttacatat tgtctttttt 19680tttttttttt gagacagagt cttgctctgt tgcctaggct
gaagtgcagt ggtgtgatca 19740tagctcactg cagccttgac ctcccaagcg caagtgatcc
tcctccttca gcctcttgag 19800tagttgggac tgcaggcatg tgccagcatg cctggctaat
tttttttttt tttttttttt 19860tttttttttt tttttttttt ttttttttag gtacagggtc
tcactgtgtt gcccaggctg 19920gtcttgaact cctggtctca agtaatcctc ccaccttggc
ctcccaaagt tttgggatta 19980cagggttgag ccactgcacc cagtctgtat tgtcctttga
ggaatatctg ttccggtcct 20040ttgcccattt ttaaatcagg ttatttgttt tcttgctttt
gagttgtttg catttcttat 20100ctattttgga tattaactcc ttatcatatg gatggcttga
aaatattttc tcctgtttta 20160taggttgtcc cttcactctg ttaattgttt cccttgctgt
gtacaagttt ttaaatctgg 20220tataatgatt gatttctaaa tgttaacttt gcactcctgg
gggtaaattc atttggtcaa 20280gatgtattct tttaaagtgt tattggattt aatttgctag
tattttgttt agcatttttt 20340tccaaatatg tttatgagag agattccagt gtaatttttt
tccttttcat gtccttacat 20400attttggtat catgtttata ctctcatttt aagaatgtgg
gtaagtgttt tttattttct 20460atttcctgag agagtttgta taagctcaat gtttcttcct
cagacatttg gaaaaattta 20520ccagcaaagt cactgggcat tacattttct atgtggaaaa
gttttaaatg gtatattctg 20580agggctctgt tctgttccat tgatctatat ctctgttttg
ctaccagtac catgctgttt 20640tggttactgt agccttgtag tatagtttga agtcaggtag
cgtgatgcct ccagctttgt 20700tcttttggct taggattgac ctggcgatgc aggctctttt
ttggttccat atgaacttta 20760aagtagtttt ttccaattct gtgaagaaag tcattggtag
cttgatgggg atggcattga 20820atctataaat gaccttgggc agtatggcca ttttcacgat
attgattctt cctacccatg 20880agcatggaat gttcttccat ttgtttgtat cctcttttat
ttcattgagc agtggtttgt 20940agttctcctt gaagaggtcc ttcacatccc ttgtaagttg
gattcctagg tattttattc 21000tctttgaagc aattgtgaac gggagttcac tcatgatttg
gctctctgtg tgttattggt 21060gtataagaat gcttgtgatt tttgtacatt gattttgtat
gctgagactt tgctgaagtt 21120gcttatcagc ttaaggagat tttgggctga gacaatgggg
ttttctagat atacaatcat 21180ggtatattca atttttaaat tactgtattt gtttgttctc
atattgctat aaagagctat 21240ctgagactgg gtagttttta aagaaaagtt gtttaattga
ctcatggttc cataggctgt 21300acacaaggca tggctgggaa ggcctcagga aatttacaat
catggtagaa ggtgaagggg 21360aaaaaagtac atcttcatac agcaacagga aagagacagc
aaaggacgac atgctgcaaa 21420aatttaaata accagatctc atgcaaactc actcactatc
atgagactag caaagcgtaa 21480atccatccca tgacccagtc acctctcacc aggccactcc
tctaacactg aagatcataa 21540ttcaacatga gatttgggtg gggacacaga accaaaccat
atcaattata tatagaatta 21600ttcaaatttt atatttcttc ttgtgctagt ttaggtaaat
tgttttaaaa ggaacttcat 21660ttgtttttaa attggagaat attcctgttg tcttttacat
gtttcaatat tgtaagctct 21720ggtaataatg tctacttttt aattcccgat attgataatt
tatgttttat cttctttttt 21780tcttgatcag tctttctagt gttttatcaa ttttaatgct
tttaaaaagc caacgtttta 21840ctttgctttt ctttatttta tttttatttt tctctgattt
ctgctcttaa gtactttcat 21900ttttatggtt tttggcttaa tttgttgcaa cttcttgaaa
tgaaaattta tttaataaca 21960ttgttcagcc tttcttctcg tcttgtgtat gaatttaaga
ttatgaatat cttagtatac 22020acttttactg cgttttactc attttcatta ttgattcaaa
gtatttttaa agttattctt 22080tgtaccatgg gttctatgaa aatatattga ttaatttaca
aatatatgcg ggtttctagt 22140tatttttctg tatatgctgt ggtacttttg tcagtggtta
tattttccat aagagatttt 22200taatttaggt gccattggca aatttccatt aattcaaatg
cagaacttca catttttcaa 22260tgcatacgtg agtttttttt gttgaggtat taagaatagc
ataaatttat aaaatattaa 22320gtaatcattg aatgcaaaat atgtcctatt ttgcaactta
atatactttt attaggttga 22380cgctaaagta attgcgtttt ttactcatac tttaatggca
aaaaccacaa ttacttttgc 22440accagtctaa taatgagaat tattattatt attatattgt
cttttttttt tttggagtgg 22500agtctcactc tgtcacccag gctgaactgc agtggtgtga
tatctgagcc ttggctcact 22560gcaatctctg cctcccaggt tcaagcaatt ctcctatctc
agcctcccaa gtagctggga 22620ttacaggcac gtgccaccac gcctggctaa tttttgtgtt
ttcactggag aacagggtct 22680cactacattg gcctggctgg cctggaattc ctgacctcaa
atgatccccc cgcctcggcc 22740tcccaaagtg ctgggattac aggcatgagc caccgcgcct
ggccctaata atgagaattc 22800ttatcaaact gtttacacag aataacatga gtgggtaatg
gtgaagctga gtttcacatt 22860tttatgcgat attcttcagt gttgctattt gttcagtact
tttaagaatt atataaattt 22920tttatagtct atacataaag tcaatattat gggtcccaaa
tatataaaat gtttgcttgt 22980tccattgttt atgttttgaa tacaaattat attttgtatg
atttcattaa taatttgttg 23040agaattttat ggcctaacat gtggtctact ttctaaaata
ttccagcttc atttgaaaag 23100gatatgcatt cttcagttgt taggtgtttg cttttgattg
cttgtatttc tcagtcaaat 23160gtaggaagtg gagattaaga aaagggctgg cacttttggt
gattgaggag gagaaagtat 23220gagatagttg tcttggatag tggaagagta aatgttctaa
agaaatataa aatgatagtt 23280gagcagcact aagggcccat ttgagtatga atctaaagag
ggaccaatct gaatgcatgt 23340gttttcatca gtgattttta tatgtgtggg taaaagctct
gagtagacag agataaactg 23400aactctttta gagtttcttt gttatctttg gtgtttggat
cctttgcttt gatttgtatc 23460ggtacagttt ttaaaaaatt aaatgttatc tcctctcagc
agatcttttt aacatgaacc 23520cagcatcttt aacaccaata aaatttcttc tattattttt
cttccctgtg ttttcattcg 23580tcctccatct agagcttctc tttagaattg tactccctgg
attgatcctc ttatttctta 23640cttttatgct cataatattt ttttctttct gtctgtctct
ttctctttct gagtctagga 23700cctgggagtt tgtcttgact gtcttccaaa ttatgagttt
gatcctttga gtcgtattat 23760tcaactcttt cactgaattg tcatctatct ctttttcttt
aatgtataga gaatttatta 23820tgcacagcca cttgcaaact ttaacaagta tgattagagc
agcattttct ataacagcaa 23880cacataagtt ggaacaacac aaatcttaaa ataactggaa
tggatgagca aattgggtgg 23940tccgaggctc agacatcagc aggtgttaaa cacctgtggg
aaaggagaga acgatccatt 24000tatttatttc tataggaaat gcaaaagagg caaaattaag
aaaaatactg cttcatgata 24060aagaataaag ccgtgaagaa tatccacaaa attgtgtata
gtggctacat ctgatacaga 24120atggaaacag ccaggataga gcagcacagg aacactatga
aatgcccagg ctgtcttcat 24180tactagtcag gatttttttt tttaattttg taaactttat
ttattctctg ctcctttttc 24240ataatctagt gatgctttat gttttcaaaa tattcttaaa
tctctctgag aataccgaga 24300aagattttaa accaagttat cttccctgca ttatctgttt
cttctggggt cagttgtttt 24360ctggtccatt ttggtcttac tcttttattc ctacaacccc
tgccccatcc ccatcctaac 24420tgtaataatc cttgataatc attgcatatt tatgcttttt
atgtgtgtgc agacaactgt 24480ttttatgctt atagatgcct tcctctgtgt attttttttc
ttcagttaaa attttttttt 24540tttgcagtca cagtcttgct ctgttgccca ggctggagtg
aagtggtgcc aacctagctc 24600actgcaggct caaactcata agcttaagcc gtcctcccat
ttcagcctcc caagtagcta 24660gtactacagg tgcacactac atgctggcta atttttagat
ttcttttttg tagagacagg 24720gtctcgcaat gttgccgggg ctagtcttga gctccaggct
caaacgatcc tctcgccttg 24780gacttccaaa ttgctgggat tggaggcatg agccatcgca
cctagcctat gtatgtttta 24840aatagagtct atttcctcta ctctgtcatt ctagtcctat
ctacttttga tcttcctgga 24900attactgtaa atttctgatt tgctgatagc accttttctt
atttgtcgga gccgccatga 24960attcgtttat ataaactttt aattttactc cttttagcta
ctgttgttac ctgttttact 25020tttatatcta ttttaagccc taccatacac cgttattatt
catgctttaa acaattgtca 25080gttgtctttt ttttttttag acggagtctc gctctgtcgc
ccaggctgga gtgcagtaaa 25140catgacctcc gttgcaacct ctgccttcgg ggttcaagca
attctcctgc ctcagcctcc 25200cgtgtagctg ggattacagg cgtgtaccac tatgcccggc
taatttttat atttttagta 25260cagacagggt ttcaccatgt tggccaggtt ggtctcgaac
tcctgacctc aggtgattca 25320cccgcctcgg cctcccaaat gctgggatta caggcgtggg
ccaccacgcc tggctgtcag 25380ttgcctttta atacatttaa taaatggaag aagaataata
ttataattaa tcacatattt 25440actatttttg agctcttcat tcctttctgt aaacctgagt
ttacatgtaa tatttccttt 25500aatccacatg attttcttta tcagttcttg agtgtgagtt
tgttggtgat gtactctctc 25560agcatccatt tatctgaaaa catatttgtt ttgccttgaa
ttttgaaaat tcttattttt 25620tataatacaa cagatccagt agtatgagaa ttatttttca
ggattgtaga attctgggtt 25680gacagctttc cccctctccc taccagtact ttgtcttctg
gcctccatta cttctgaagc 25740gatgtcagtt ctatttcttg tcttggttct cctgtatgta
tgtgactgct tttaagatta 25800tctttttgtc tttggttttt agcagtttgg ctataatgtg
acttaagtat ggatttgtat 25860agattggatt cagatgaact ttttggatcg gtggtttgat
ttttttaaac aaacttggaa 25920aacatttagc cagtattttt tcaagtattt cctctgttcc
acttatatgt atcagacttt 25980gttactcttg ttgttcagtg gtgtgatcac ggctttctgc
agcctcaaac tcctgagcgc 26040aagtaatcct cctacctcag cctcccaagt agctgggact
acgggcacag agcaccatgc 26100ccagcaaatt aaaaaaaaat ttttttgtag agatggggtc
ttgctatgtt gccagggcta 26160gtcttgaact cctggactca agcaatcctc ctgccttggc
ctcccaaaat gttgggatta 26220aaggcatgag ccatgactcc tggcctagat ttcttgatat
tgtagagttt acatatggct 26280tctttatctt catgcattat attaattttt tactgtaaat
tctattacat atgtatcata 26340gtaaacaaag tctttaaaat aaattctaat atttgggtct
gctttgggtc catttctatt 26400atatatattc ttcttttcat gtttaataag tttcagctga
ctattgtaca ttgtgggtga 26460tacagtgtag aaactccgga tgatgtggat ttcaatcttt
ctctgaagta atgagttttg 26520ttctagcagg cagttaaatt tactagcaga ccaacttgat
cctgcggagg cttggtttta 26580ggctttgttg ggacaggtct atttcagttt tgccattact
tctggtaagt ggctcttatt 26640cttcaagtgt ggcttttctg gcgtttcagt ggaaagcctg
agatatttac cagttccctc 26700taacactaaa tcctgactct ccaggaccag atagctgttg
aaatctcttc ccagttcttt 26760cagatttcta gctattgcct gtccctgggc ttcgattttc
atcctatgga tgggaattca 26820ggagtcaggc cccactgact cccattttcc tgagatttct
gccctcaatt tttggctttt 26880ctagcagctc caaacttcat tctctgatac tttcacccag
taagactgca gctttttaca 26940agagctctgt cccctcctct ggcccctgcc tgtacacaac
agactgtgta tgtagttgtc 27000tcaggatgga agaagagtaa gtatgggcct cattcagtgt
attccccttc tttcaagggt 27060catatccccc cgatttgtat ctgcttttgt ttctttgaca
atgccttcaa atggtgtttt 27120tataaatata tatttttaaa aagtttataa ttgtcgtcat
caggaacatt agtgtagtat 27180aaactactct ctcattatca aaaatctgta tgttaaaaat
tacttaaaat tgttgttatt 27240tatcatttcc ttggtgtttg gggcagaagg gaatgcacat
gatttttctg aacttctcat 27300taagggaggc aacccagcct tggtctggag atcccgaaat
tataccgtat gtataataaa 27360ataattattt tgttattttt atgagcatag cattaataaa
ttaaatattt agtaagattt 27420gtatctcagg atttttctac ctgctaagaa tagatcgttt
gacaaggcag atgaggttct 27480ttgttgaatt ataaggtatt gaagcctata atttagtagt
ggaaagagca catagcaaga 27540gttgtatgat gaggttggag aggtaagcag caaacagata
atggaatttt agtctaaaca 27600ttcgtaaaat atgagggtgg ctcctgtggg agattaggtt
attgggaggc aaagtagact 27660tagggaaaat agttaggagg acattgcaat agttcaggag
agaaataata gctgtttagt 27720gtatgatggt agttgtggaa aaaaaagcca atggatggat
ttgaaatata gtttggaagt 27780aaaactatca gtacatattg atggactgga tataggggtg
aaaaaagaga agaataaagg 27840ttgaccaaat tctttattat ctcaaagtat gaaagcttgt
taagacctct tttctgtttg 27900tattttcttt cttgctcaat aagaaaacaa cccaaagcac
tttttttcta ataacttata 27960tcttcttctt ttgtgataaa aaaaaatagg agtggtcttt
agagtacaat acaaaattct 28020tttacatttc acctcaccat atttaggttt accaaagtag
tataggaata attgtaggaa 28080aaacatagta tatctacttg gactataaaa ttttggtata
ctaaagaaag taaatcaaaa 28140tggttatatc ttgcaataga atgcaaaatc acatggatat
taaaggtaaa catttaaatg 28200tattttatat tcttggcttc ttcttcagac cactccattg
ccttttggga catttctgtg 28260gaaaagttga gaagcactga cctatctgaa ccttccaatc
cagccaaact tgtctctact 28320ttgttccagg aacatgctgt gtacattcct ctttccatgt
tttgcatgct tttctccctg 28380ccaataatgc cctgtttttc attacttgtc aaaattctat
tttcctttta aggtccagcc 28440tatgttttaa ttgttgtgtg aaacttctaa aacctttctt
tgttttaaat aattatgatc 28500attttcttct tgtcattttg tagcacttaa tttttaaaat
ttattttgta cttagatgat 28560gtgtaattta ctataaatca tagattttta agaattggga
ggaacagcgg aaatttaatt 28620aagtaatttt attatacaag tgaggaagct gagattcatt
tgtcatgtaa gtagtttgca 28680ataagaaagg atgaaactta tttttaggtc tcttggctcc
caggttagta atttttctaa 28740tctactgcat tacttcttca tgtatattta ttgatctgaa
aagttgtgtc tcttagaatt 28800atgtagtata tgagtaaagt ttgaaaatat gaacttttaa
aatgtgatat ttgaggtact 28860ggtttttgag tgtatgtgta cagttgatta aaatttatta
taacttttat ttactctttc 28920tttttttttt tttttttttc gtagagacag gttctcacta
tgttgcccag gctggacttg 28980aactcctgag ctaaagtgat cctctcacct tggcttccca
gagtgcaggg attacaggtg 29040tgagccactg tacccagcct cttatttact ctttattcaa
cagatttgtt aatcaacaca 29100tgttgaccag acttaattac agcttttata tactcttcat
ttattcaaca actttcatgt 29160gtcagagagt atcctaggca ctgagtgcag tagtaaataa
tacattaagg ttcttacctt 29220caagaaactt tcattctagt ggtacaagac aatgagcaaa
atcataatct aatctatggt 29280gggaaaatat cagaacagct gtggccactt gagtggttgg
agcagggact gatggagaag 29340gagcatggaa gaactttctg ggatgctgat aatttcttag
ggctttgggt tacataggta 29400tatgcagtgt ccaaacttat tgactggtac acttaagatt
tgtgcatttg attgtattta 29460ggagggaaaa tcctgtaaaa ctagaataga tgtaacttat
atgagagtta taaatgacaa 29520tatgttaaac acccatgaaa ctaccaccca ccccaggaac
tagaatgttg ccagcaattt 29580gcacctacat atgtgtttct ccctagctat tctcctgtct
atcttgcaga agtaaccatt 29640gtgtattgta ttttgggatt aacatttcct tgatttttta
tttttttttt gcgggggcgg 29700ggggagattt gtttaacaca tgtatatgcc taaacaatgt
actattcagt tttgcttgtt 29760tttgaaattt agaaaaacgg tattttacag cttacagttt
tctataattt actgcttttg 29820caacattgta tttttaagat ttatccatgt tgcataaagc
tatagttcat ttattttaac 29880aactgaggaa cagattctgt agtataaatg cacaaaagta
tttacctatt ttcctgatag 29940tttgggttgt ttgcagtttt tgccattgga agctgaggcg
caatgaatat tcttgtaatg 30000tgtctcttgg tgtaaatatg catgaagttt gtaactagac
gtagaattgt agcagttctc 30060agaacgtggt ctctagagga tgcctgggta tcctaaaaac
ctattcaagg gtttaatgaa 30120attaaaatga ttttcataat aatgccaaga tgttaaatgt
ctttttcatt gagttgacat 30180atgcacaaat ggtacagaag taatagtgag ttaaacggct
ggcaccttag cacaaatcaa 30240agcagtaatg ctggttgtag ttgtgatcat tgtattcttt
ttctttttct tttctttttt 30300ttttttttga gacaaggtct cactttgtta ctcaggttgg
agtgcagtgg catgagcaca 30360atcactgctc actgcggcct cggtctcctg ggctcaagtg
atcctattgt tttctttctc 30420gtcatgtact tccaggaaaa gaaaaaagcc aattcgagtc
acttattctt ttgattcttt 30480ttcgtagcaa agcatcaatg cattttctaa atgattgaat
tcatttaaat tcgggaaaca 30540tttactgagt gcctatggaa ttctgggata tgagtgtatg
tttaaggcag tgtgatttcc 30600agttaccatc ctttctgttc taaacacgat tgtgtcatat
taaaatataa aaagagtaaa 30660aaatatcctg aataaaaata gatcaagctg tacatatata
tagattataa gtgcaaaata 30720ctgagtgtgg ttaaagccta tgctatgctt gctgggtttc
ctgtacagaa gtaggcattg 30780gagacagttt tgctcttgtg gtacaacatg gatgactaga
ggcaggtcca ggatgttact 30840tttactgcca gccgtcgctt ccctccaaat agactattgg
aaggggaacc tcccgccaaa 30900cgctgcctac tgctatagtg ttggataagt tgcaagctta
ggaagatgag atgacatgat 30960ttaggaactt caggatgaag tgaagtatct cctgccttgt
gactgactgg atctgcatcg 31020tatcagatac ctcctcaagg caggaatttt aacctgctgt
tataagacct ggttctatat 31080atggatagcc caggtaggct aagttgtggc agccacagat
tgttagatga ggagggacac 31140cacagactgt gtatgtgtgt gtgttgaggg caaggtgagg
tgaggaatgg tgcaatgagc 31200ctgcaaacca aattgcaaaa tatatgaaga aatgtagtgc
taagaaaaat agtcaacaaa 31260attaaaaatt gaaaaatgaa ttttttcctg ataaaattta
aaaatgtaag taaacctcta 31320attgaagtgt aacacacaaa caggaaagta tgctactcat
aaatgcacag cttaacaaat 31380tttcataaag tgaacacacc tttgttaacc actacttaga
tcaagaaata gagtatcacc 31440tgaattactg gcaggaggca ccccagaggt ctccctgtac
ctcctgccag ttattctcca 31500tgccctccca ctatcccaac cctgccaagc taaccattat
cctaactttt tttcaccatg 31560agaaagaaat ggaaggatat ggaagtgagc ttgagaggcc
tccatggtca gtgaacagtt 31620ctgctaaaat aatttagagg gaataacaaa gaagtagcat
ttgacggcat agtagctgag 31680aatttcctag aatagaaaaa agacatgaat ctttagatta
aaagtatgta gtcatttttg 31740atcaagataa agaagaatct acatcaaaac ctttccaaaa
atattgcaga acattgctgc 31800taatgcaaac aagttttaaa ctacttgagg gaaagccatg
acatgtagga gtgatagcag 31860acttcatatt tatgttaata gataccacaa aacaatgcag
taatatcttt aaagttctgg 31920ggaaagaaaa ttataaatag gattttgaga gtgagggcaa
catatttttt tcaaagacta 31980caacttaaaa acccacagag ccccactgaa aggtctacta
aaagatacat ttcagcagga 32040aaaagtgagt cctgaaggaa gacccaaaac aatgatgagc
acaaaacaat ccaaagtcag 32100tggtgggcac aaactgataa aattctagca aatttactcc
ttaatgctaa gaacttcgtt 32160taaattaact ttctatcttt tcagaaaacc aactcttaga
tttgttaatc ttttccatca 32220tttttatagt ttctatgtca tttatttctg ctgtgaactt
cattttttcc ttccttctgt 32280tagctttggg ctttgttctt ctttttctag ttccttgagg
tgtaatgtaa tgttgtttga 32340catctttctt cctttttgat gtaggtattt attgctataa
acttccctct tataactgct 32400tttgctgcat ttaatactga ctataataag atacgatgta
atagatttca aggaattatg 32460tatttttgaa taaattaatt ctttaaagtt gcatatccag
ttgcagatga acttcaaaaa 32520tcttgcagtt ttatatctgt tacagtaatt gccaggtttt
gttgttgttg ttttgataca 32580ttagaagttc tagaattgtt atatcctctt gatgaattaa
tccctttatc attctagaat 32640taccttgtct ctttactgtt tgtgacttaa agtctgttgt
atctgatata cctttgcatg 32700gaatatcttt ttctatccct ttactttcag tctatgtgta
tctttaaagg tgagatgagg 32760ttttgtaagt ggcatgtagt tgggtcatgt tttttagtcc
atttagccat tctctatctt 32820ttaagtggaa agtttaatct atttacattc aagtttattc
ttgatatgtg aaggcttatt 32880cctgtcattt tattaattga tttctggttg ttctgtaggt
cctttgttct tttctttctc 32940tcatattgtt tagcattgtg gtttgttggt tttctatagt
gataacattt gaatcctttc 33000ttgtctgtgt gtgtttgctt taccagtggg tttgatactt
tcgtcatctg tttttcataa 33060tggtagtaat tgtccttttt gtttgtttgt ttgtttcttt
tttgagacag ggttttgctc 33120ttgttctgtc ctccaggctg gagtgcagtg gtgtgatcat
ggctcactgc agcctcgacc 33180tccatggtct caggtgatcc ttctgcctca gcctctcagg
tagctgggac tacagaaacc 33240tgccaccatg cctggctaat tcttttgtat ttttcgtaga
catggggttt tgccatgttg 33300tccaggctgc tcttgaactc ctgggctcaa gcagtctgcc
tgcctcagcc acccaaagtg 33360ctaggattac aggcttgagc cactgtgcct ggcctgacat
tgttctttga cttccatatg 33420tagaactccc tcaagcattt cttgtaggtc tggtctagta
gtgttgaatt cctcagcttt 33480tgcttgcctc agaaaaacta tttttccttt gcttaatgaa
ggataatttt gctgggtata 33540gtatccttga cttgcaggtt tttttctttc agcacttttc
atatatcgtt ccattctctt 33600cctggcctgt aatgattctg ctgagaaatc tgctgttagt
ctgatggagc ttcccttaga 33660agtgactaga ctcttttttc ttgctgtttt tagaattctc
tctttgtctt tgacaagctg 33720ttgtctctga caacagttct ctctttgtct ttgacaaact
gttgacagtt tgactctaat 33780gtgttgtgga gaacctgttg gaattttgtc tttttgggga
tctctgagct tctgtatctg 33840aatgtctaaa tctcttgata tacttgggta gttttcagct
attatttcat taaccaggtt 33900ttctattcct tttgtatttt cattgtcttc tagaatactg
aaaattctaa tattagtttg 33960ctttatggta tcccatatgt catgcaggct ttgttcattc
ttttttcttt atttttgtct 34020aatggggtta tttcagaaga cctgtcttca agttcagaaa
ttctttcttc gtagatgctc 34080tagaatgtat tttttatttc attaaatgaa ttcttcagtt
tcagggtttc ttgttttctt 34140tttaaatgat atctctctct ttggtaaatt tctcattgat
atcctgagtt gtttttctgg 34200tttctttgta ttgtttatct gtatgcgttt gtatctccct
gagcttcttt aatatcatta 34260tttttaattc tttttctggc atttcatgaa tttcttttgc
attggaatct tttggtagaa 34320aattattttg atcctttgga gatgtcatat ttccctatgt
tcccatgttt cttgtgacct 34380tacttctttg atatccacac atctggtgta atcatcactt
ccattttttt gaatttgctt 34440tcatagggta ggactttttc ctgaagattt gactggggtg
tttgttggcc agggcacttt 34500gggtttgaat ctgggtgcat gcagtagtgt agtctctgta
agattttttt tcctttgtaa 34560acagcatcag tggtgtctgt gatttcctca gtggcatagt
gtgtggttgt ggaggctgtg 34620gtgaactttt gctggggatg gtgacaccag ctggactgat
cctcagtcct cagttgtggc 34680agcagttgga caaccatgcc tgtacattag ccccagggtg
gcttacatta gtaatggtgt 34740tagtgggtcc aggcagtcca atttttgggt ctccaggtga
cttgtttggg taccaggagt 34800ggcagtgatg ggctgggcag ctgagtgggt ccacaggccc
ctgggcagtg agcatggcat 34860gggttatgtc agtagcagtg gtaggagaac ctctggctgt
ccagttgtct gtgcttatgt 34920cggcagtgac ggcgattggc tgggtaggca agtcctaaaa
cctgcaggtg gcaagtgtga 34980gtgggaacca gctgtggtgg tagtggcagg ttgggtgggc
cacatcctca gacccccagg 35040tggaatgctc agttgacact ggacgtggac aaactggtgc
gatcccaagg cccccagata 35100acatgcttgg atacgtggga gtggggtgct gagctgggca
gggtgagagt atcctcaggc 35160cctccagtgg tgttagcagg tgctgtttgt ggtgggcagg
agcaggatga tttccaattt 35220cctggtggaa tgttcaggtg ggggcagcag tggctgtgct
gtgccctgat gctggggagg 35280gtgcagttgc tgtcagtggg agcagttgta gggagttggc
taaggagtgt gcactgcagc 35340tgcaggtgga ggctgtagat gtgatgaagc tgtactcagg
gtgcatgcaa atttgcattt 35400tgacacctag cggcagcagc ctgcaatggt ggcagctgta
ggtggtagag cttgtcctca 35460gggcacatac caatatatgg cagcccttct gctgggagca
gtggggttat tgccaatggc 35520ttgtgctttg gtcccagagg cggcagccag caatggaggt
gactgtcggt ggaggatgtc 35580agtggggctc taggggtgtg gatatgcagg ggctgttggg
ctccagggta ggaggcattc 35640tggtgtgggt tgggctttaa aaatggcacc gtgctgtagc
tgcttaggac tcaggggtgt 35700gttggaccag cataagctcc ctctctaaag caatgtcatt
gtgcagtctc caggcagctc 35760cctatgttac tcccagggcc catgaaagtt gacgggctct
cttgtgtctg ggattgcagg 35820agtttgcagt gaaaatgtgg gccactggga gtctctcact
tactctttcc ccacattgtg 35880caggctctct aggcttctgg ctgatcctgg ctgagcaggc
tgccccactt ccctctcctt 35940ccttgcatta ggtgttttct atcacttctc tgttgaattt
ccgtgttctc tcttagatga 36000cctattcaaa gtgtgattat ctactcgcta ttttggttct
tctttgtgga gcaggtgagt 36060accagataac tctagtcaac cttctggacc cctcttcccc
caatttgaga tctcttcttc 36120tgttgtctgt aactgagttt aatgcttgtt tgttcatgtt
aggattttat atcatcgtcc 36180tcaattaggt tgttaactgg aattttataa tctttgtcca
caggaagttt aaaatgtatg 36240atttcttgca ttgtgctttg tatgtagtaa tacacgatat
ttatccagtt aatggatttg 36300acagccattg ctgtcaagga gcagtccttc tttgtgtatg
aagggtgcct tatcaatatt 36360atttccattt gtaactttat ttatttatgt attcattttt
gagacagggt cttgctgtgt 36420cacccagact ggagtgcggt ggagtgcgga ggtttgctgc
agcctcatcc tcccaggttc 36480aagcaattct tccgctccac tcccagagta gctaggacta
caagtgcgtg ctgccacgcc 36540cagctaattt ttttcttttg tatgtttttg tagagatgag
gtttcaccat gttgctgagg 36600cttgtctcca acttctgggc tcaagctatc tgcccgcctc
ggccccgcaa agtgctagga 36660ttacaggtgt gagacactgc gcccagccca tttgtaactt
tattgttttc tcttacaggc 36720aaatgttctg aaaaagactc tgcatgggaa tggcctgcct
tacgatgaca gaaatggagg 36780gaacatccac ctcttctata tatcagaatg gtgatatttc
tggaaatgcc aattctatga 36840agcaaataga tccagttctt caggtgtatc tttaccattc
ccttgggaaa tctgaggcag 36900attatctgac ctttccatct ggggagtatg ttgcagaaga
aatctgtatt gctgcttcta 36960aagcttgtgg taagtattaa aaaacagcat tttccttttt
atgcatggat tgttttaatt 37020atgctatgct aatactaggt acatgcataa tatatatttt
tattttttta atgcttgtat 37080ggctggcgtg tgtgttttca catgcataga aaatgaaagt
gttactggag tacaatttat 37140ggtgaatctg ccttgggcta ggtatcaaaa caaattgatg
cccataaatg tttgctgact 37200attctttata attacatata aggtggttaa aaaatcctgt
catgggctat ctcatgacat 37260aaggtaatat taaagctaga tcctgagagc aacatgaaag
caaaaaatta atgttttgaa 37320atatgtattt gatttaaaat cttgattaaa tggctgacaa
accatcattt tcttctagtt 37380agcttctgaa gacctctgcc aatctttcct catatatatt
tcttatgtct ttggtgtatc 37440ttgaaatcat ttttactctt gagacctgat tatattatct
atggaccaaa actgtgaacc 37500agagaactct ttctatagag ctaacacatt ttactagacc
actgaggtta ctatagagcc 37560tactatcatg gtatctcatt tttaaatgtt cttttaatag
aaagactagt tgacactatt 37620ttgaagaata gtcgtatgat tttatttgta gaggcaaatt
aaatgtctaa tatagtattt 37680ataagaatgt atgattacat caatttattc tcttatttaa
gatcagtata ggtcagaata 37740accattaact gtaagttgga ggaagctagg tacatttcaa
gttccttcta gctattttga 37800aaaatacaat acattgttgt taactatagt caccctactc
ttctatcaaa catttgaact 37860tgttccttct gtctgtattt ttgtgcccat taaccaacat
ctcttcattt ccctcttccc 37920acccatataa ccttgccagt ctctgctacc aatccactct
accttcatgt gatcaacttt 37980ttagctccca catatgaatg agaacttgtt atatttgtct
ttcagttcct ggcttatttc 38040actcgacata atgaccttca gttccatcca tgttgctgtg
aatgacatga ttacattctt 38100ttttacgatg ccactgggcc ccaggggagt acgcattctg
ttgtgagctg ggcttcaaaa 38160tatcaccttg ctgtagctgc ttaggactcg gggggagcgt
gggacccagt gtgaacttcc 38220tcactggaat aggaaatgct tttgtgctgt ctctgggcag
ccctctatgt gaattttttg 38280tcctgcaagg ggctagggtc tctcctgtga ctaaaattcc
aggggttcac agtaggaatg 38340tggaccattg ggcatctcta acttaacctt tccctgtgtg
gagtctctcc tagcttcttg 38400ccaatcccgg ctgggcaggc tgtcttgttt cgtctccttc
cttgcttttc tgttgaatac 38460cagtgttcct cttggataat ctactcaaag tgtgattata
tactcatggt tttagttttt 38520agtggggaag tggatatgag agacctctgg tcagttatct
tgactatatt gtaaagtctg 38580tattttttgt tgtgtgtagt ctctgaaatc tctgatcctt
tagcttatag taagatttta 38640gcttgtaaga tttttttagc ttttaagatt ttttagcttg
taagatattt tttagctagt 38700aagattttag cttgtaagat ttttagcttg ggccgggcac
ggtggcttac acctgtaatc 38760ccagcacttt gggaggctga ggcaggcaga tcacaagatc
aggagatcga gatcatcctg 38820gctaatatgg tgaaacctca tctctgctaa aaatacaaaa
aattagccag gtgtggtggt 38880gggcacctgt agtcccagct acttgggagg ctgaggtggg
agaatggcat gaacccagga 38940ggcggagctt gcagtgagcc gagattgcgc cactgcactc
cagcctgggc gacagagcga 39000gactccatct caaaaaaaaa tttttttttg gcttgtaaga
ttcattttta gcatgtaaga 39060ttttgcttta gcttgtaaga tttttttttg acagatttta
ttgaattcct agggccaaaa 39120gaaaataata gaaaagaaca aaaaactctt tcagtctttg
cagattggct ctgtgttggg 39180gctctcattc agtgtttacc cagtccattt acaactctgc
cttagccttc ccttcctgct 39240tgtgctgact ctaaagaaca gcttgaggtg aaagcttagg
gtcttttctt ctaagttctg 39300ttccttgggc atgcatatgg cttttctact ctccaataca
tagaaatgct tttcagtgct 39360gtcatttccc aaataaactc tcctctgtca tctctgtttt
ggttttcagt gtgtttattg 39420tttgcctcaa ctttagacct ctgccccaga tagcaacagc
ttgttcattt gcaatgtttt 39480caatgaatat cttctgtgaa gctgcttttc tgccctgaga
aagtcctgaa ttaagtggaa 39540cataggtgtg ctctttgcat catttcttca gtcagtcccc
agtcagggca aaagagagaa 39600aaacagtttt ttgagattaa ggttggctct gttcactcca
gagccaggga ccagagtttc 39660acactgggag caccaattgc catcttcaag actttgctta
actaggggga gtggagccgg 39720ggctggtggg caggacatgg gcgtagtggg tggttaaggg
aaagtaaaaa tgctgcacaa 39780ctttcctgcc atttttaagt ggctgttttc ttgattcagc
atttatctga ttgctgcata 39840tctttgccta ttttctgtag tttatatgaa gttcattctg
acagttttta ctcatttttt 39900ttttcctgtt tctgggagaa ggataggtcc ttggaactac
ctactccacc attttcactg 39960atgttactct tttacttttc taatcatgga agtaaagttt
aagatttttc tatctatatt 40020ggtgagatta cccttggtat cgtagtcaaa ctaaattcac
aaaatgtgtc aatttctctg 40080ttcgctcttg gtctattctc tgtgatagta tacttaagat
ggaattgtct ttcatgtttg 40140gttgaactca aatataaatc ttgtctgggc ctgatggtgg
ttttttcttt cttcattgtt 40200attttgttat tcttcttcct tcccttcttc tgtctctttc
ttgctccttc tttcttttct 40260tcttcttttg tttaagtgga tagagtttgt ttcctttttt
tttttttgag actgagtctt 40320gctctgttgc ccaggctgga gtgcagcagc atgattatgg
cacactgcca cctccgcctt 40380ccaagttcaa gtgattcatt tccctcagcc tcctgactag
ctggactaca ggcacccacc 40440accacaccca gctaattttt gtatttttgg tagagacggg
gtttgccatg ttggccaagc 40500ttatctcaaa ctcctgactt caggtgatcc acctgcctcg
gcctctcaaa gtgtgtgagc 40560cactgcaccc agccagaatc tatttcttta atggttatag
ttctgttgaa gttttaaatt 40620aatgaatctt tttaaagtta cattttcaca aaaattgtcc
atctgtctat attttcaagt 40680ttattggcat aatgttgttc tagcactctt tgtcttcata
acttataatt atgcttttta 40740aaagttctta gtgtttatct gtgcctcttt ttttcttatt
atccttgaca aagatctatt 40800ttgcaaagaa tcatctttta ttttgttact tctccctatt
ggatttttat catgtccatc 40860tctaaccttt ctttgggatt actctattgt cttctactat
attgagttag atacttagat 40920catttgctct tattttctaa tataagcaga taaagctaca
atttttcctc ttgagtttca 40980ccttagttgt attccacaat ttttagtaca tgatattggt
aatcattatt cattataaat 41040gcctcccaat gtatttttcc tttgacttct gagttatttg
gaagttattt gtaaataaaa 41100gaatgaatgc aagtatactg tttaaaagtt gctgctaaat
aatgttatta taaataactt 41160accgaaatta ttacacatct gtaagtagac ggtcgtgtta
ataatttaaa ttaagaattt 41220aagtctttct tgtcagtttg tcatttgtgc cgtttctatc
tacagtggaa aatagtgaaa 41280acataactag aataaaatac ttttgtgttc tgtgagcctt
atgttttaaa tatataggat 41340taaaaaaatt ttacatattc atttctgatt taattgaagt
gtggttagag aacatggtat 41400gaatggttat tctgtggaac ttctaaagac ttgttttgag
ttcacgtgat tgttgtgttt 41460gtgcttgtgt gtgtacgtgt atgcgtatgt gtgaatgttc
tatatatgct tgaaaatagc 41520ttgtattatt tacttgtgtg gtttaggtat tctcttggtt
ttttagttca gtggctttca 41580accatttgtt gatgtacctt ctaaaatatc ttttaagaaa
ttacatatgc actcacattt 41640taagttgata tttaaaattt ttcattgtaa attaaaatag
cccaaaggac ataattatta 41700atgtattgtg taaaacttga cacattgttc ttttaagagt
attcatgact tctaaatatt 41760tttgtgattt gatacctatt aattaaaaca actccttctg
tgcaaccaca tgcaagcatg 41820gatttttatt atacctccag ttcagggaaa cttgaaaatt
tgaaccaacc tttctataga 41880ggacaactga agaaaccaga tgaaatgttt taaaaatatc
tgcttgaaag agtctcagca 41940gttatatttt aaaatactga cacacctcgg agatattgtg
ggtttggttc cagactatcg 42000cagtgaagca aatattgcaa taaagcaaat cacatgaagt
tttaggtttc ccagtgcata 42060taaaagttat gtttaaatta ttctgtagtc tgttaagtat
gcaataatat tatgtccaaa 42120aaagtacata ccttaattta aaaatacttt attgtcaaaa
agcactcata atcatctgag 42180ccttcagtga gtcataatct ttttgttagt ggagagtctt
gccttgatgt tgatggctac 42240tgactgacca gggtggtggc tgctgaaggt tgggtggcta
tggcaatatc ttaaaataag 42300acaatgaagg ttgctgcatc agtggactct tcctttcgtg
aaagatgtct ctgtagtatg 42360caatgctatt tgatagcatt ttacccgcag tagaacttct
ttgaaaatag gaagttgatt 42420cactcaaacc ctgccactgc tttgattaag ttgatgtagt
attataaatc ctttgttgtc 42480atttcaacaa tattcacagc atcttcacca ggaatagatt
ccatctcaag aaaccacttt 42540ctttgctcat ccataaaaag caattcctta tatgtccaag
ttttatcgtg agattacagc 42600aattcagtca cgtcttcaag ctccacttct aattttagtt
ctcttgttac ttctaccaca 42660tctgcagtga cttccttcac tgaagattaa atccctcaaa
gatacccatg agagccagaa 42720tcagcttctt ccaaactcct gttaatgttg acattttgac
ctcctctcat gaactacaaa 42780tgtttttcat gacgtctaga atggtgaact ctttccataa
gtttttttat ttactttgct 42840tagatctgtg agaggaaaca ctgtgacagc cataacctta
ctaaatgtgt ttcccaaata 42900ataagatttg aaagtcaaat tgctccttat ccatgggctg
cagaatggat gttgtgttag 42960caggcatgaa aacaacatga aattcaatgt acatcttcat
cagagctctt gggtgaccag 43020gtgcattgtc aatgagtaat aatacttgga caggaatctt
tttttctgag ctttaggtct 43080caacggtggc ttaaaatatt cagtaaacca cgctatatac
agatgtgcta tcttctaggc 43140tttgttgtcc catttataga gcacaggcag ggtaattgag
catagttctt aatggccata 43200gattttcaga atggtcaata agcattggct tcaactaaaa
gtcacttgtt gcattagctc 43260ctcagaagag agtcattcag ttctttgaaa ctttgaaggc
aagcactgac ttctttctag 43320ctatgaaact actcctagat ggtatcttct tccaatagaa
ggctgttttg tctacactga 43380aaatctattg tttatcagtg atctttgtta gatctttgga
taacttgctg catcctctcc 43440atcaacactt gctgcttcac cttgcacttt tatgttaggg
acatggtttc ttttcttaaa 43500cctcatgaac cagcctctac tagcttcttg cttttcttct
gcagcttcct cacctctctc 43560agccttcaca ggtttgaaga caattagggc cttgctctgg
tttagggttt ggcttgaggg 43620aatattgtgg ctggtttgat cttctatcta gaccactcaa
acttttgtca catcatcaat 43680aaggctgttt tgctctctta tcatttatgt atttactgca
gtcgcatttt taatttcatt 43740caaaaacttt ttctttgcat tcagaacttg attgactggt
gcaggaggcc tggcttttag 43800cctctcttgg cttttaataa taccttcctc acttagttta
attatttcta gcttttgatt 43860taaagtgaga gatatgaaac tctttaatat atgaaactct
tcctttccct tgaatgccta 43920gaggccattg taggattatt aattggccta atttccatat
tgttgtgtct cagggaatag 43980agaggcctaa ggagagggag agacacagga atggctgttg
ctggagcggt cagaacacac 44040acagcatttg ttgcttatgt ttgtcatctt atatgggcac
ggttcatagc ggccccaaat 44100gattacaatt gtaatgtcaa agatcactga tcacagatca
tcataactga tataataata 44160aaaaagtttg aagtattgca agaattacca aaatgtgaca
tagggacaca aagtgagcac 44220gtgctgttgg aaaaatggtg ctgacagact tactagattc
acacttgctc taaatcctta 44280ttttgtaaag aaaaaaaccc cacaatatct gcaaagtaca
ataatgcagg gtgcactaaa 44340atgaagtatg tttgtataaa aaaagattgt gattaataat
tcagttgtag gggttggtat 44400atcaaaagat ttcgactgct attacatttt gttccgattt
taagagttgt tactttagct 44460tcatttcaaa ttataggtgc tatgtaaaaa tattctgttg
tgtaccttta ataattcctt 44520tctctgcttc ttttctaggt atcacacctg tgtatcataa
tatgtttgct ttaatgagtg 44580aaacagaaag gatctggtat ccacccaacc atgtcttcca
tatagatgag tcaaccaggc 44640ataatgtact ctacagaata aggtactttc ttcagtaaag
taactcactt aatgctaaaa 44700ggcaaaatgg gagaaattat caaatatttt ttaattgcaa
ggtacttaat accagatacc 44760tgaaccaatt agttagcact catttaagat ttcatttaag
attctattct gtttctccat 44820cagagaaact gtttatacat gttgtgtaag tagaatactc
tgagaataaa gctgttttgg 44880tgggatgcca cttaactcct tatgattata attaaataag
taaacaaaat cacagtggcc 44940tttattaaca aaatcctaaa tgtttgggat attgctggtt
tgtgcagcgt tttgtgcaat 45000agaatgcaat ttcacatctt atctttataa agaacttttt
aaaaagttga cgtgaagaaa 45060agagactttt cccagtgtgt atttgcagcc tcaaattgta
agttaattta tataatttat 45120ggtaatgtgt aatgcctatt tagagaaatc tagaagtatt
tttttgctcg aaaggatgaa 45180acaaagatac gtttgatttg tgtctcacaa atacctgtga
tttttctaag catttatata 45240catatatata taattcatca taacttcatg aggtgttaag
atttccacat taaagataaa 45300gaatttggag cactgagaag taatattact caaatttatt
catggtcaca caggtaggaa 45360ttgggagtca ggttcaaatc caagcctggt ttgcttcata
agcttgcctc ttaatcacct 45420catgtgtact tcattaaaga gataatgtat atataatatt
tattattgtg cctatcactt 45480ggtgctctct caataaattt tagtattgtt ttgcttcttt
ctcttcccct attctatata 45540aaaatatgca gttggatgtg tttgcattta ctgatgtcta
atgtataatt tgcactgagt 45600tcaaaaaaat attttttata taattattga aaagacaatt
ggtgaaaaaa ataaatgttc 45660aaagaaataa tagatgtaca aaaatcaaca gcattcttat
atgcaagcaa ccagttatat 45720aatagataaa gaagatccta tgcagtgtag ctacaaaaac
ccttaactaa ccaggaatgg 45780tcttaataag aaaaaacaga agacagtata ggaaaattag
aaagttattt gaagaatatg 45840aagaattagg acataacatt ggaatgggga gatggaatat
tacaaagatc aatttctctt 45900atgctatatc cttagctcta agccaatcaa aatcctaaca
aaggcatttt acggaatttg 45960acacattact atgtaaattg agaattatta aataagatag
ccatgagaaa gaagacttac 46020ctggcaattg taaaatattt tgtcccagga gatattttca
cattatatga aactacaaaa 46080tggtatctat tattaaagcc acataattaa attcagaatc
ataaactaaa taatgagaat 46140gatggggcca gtatatcttg aaagtactcc ttcatacata
tagaaacata ataatatgaa 46200gaaatctttt catattaacg tggaagggag agattagtca
acaaatggtg gtagaatagt 46260tgattagctg tttgaataaa attttagctt cttactttat
aatgtatatc agataaatta 46320tagattgatt aaagatcaga ttgatatgta aatagaaatg
taaagaaaat caaactataa 46380aagtctgaat tggaactgaa ttcaagtcct tgggaaaata
ccatttaagt tgcaaaacaa 46440tagaaaaaat catatgggaa tgactgcaat tgtcaactat
aaaaattttc aaatgtctga 46500aggtttcctc ttaaaatgaa aaggcaggag ggtggagcca
agatgactga ataggaacag 46560gtccagtcta cagctcccag catgggcgat gcagaagacg
ggtgatttct gcatttccaa 46620ctgaggtgta ccgggttcgt ctcactgggg agtgtaggaa
agtgagtgta ggacagtggg 46680tgcagcacac tgagcatgag ccgaagcagg gcgaggcatc
gccacacccg ggaagcgcaa 46740agggtcaggg aattcccttt cctagtcaaa gaaaggggtg
acagacggca cctggaaaat 46800cgggtcactc ccactctaat actgcgctat tctaacggta
ttagcaaatg gcacatatcc 46860cgcgcctggc tcagagggtc ctacgcccac ggagcctcgc
tcattgctag cacagcagtc 46920tgagatcaaa ctgcaaggtg gcagcgaggc tgggggaggg
gcgcccgcca ttgccgaggg 46980ttgagtaggt aaacaaagca gccaggaagc tcaaactggg
tggagcccac cacagctcaa 47040ggaggcctgc cggcctctgt agactccacc tctgggggca
gggcatagcc aaacaaaagg 47100cagcagaatc ctttgcagac ttaaatgtcc ctgtctgaca
gctttgaaga gtagtggttc 47160tcccagaatg cagctggaga tctgagaacg gacagactgc
ctcatcaagt gggtccctga 47220accccgagta gcctaactgg gaggcacccc caagtagggg
gagactgaca cctcacatgg 47280ccgggtactc ctctgagaca aaacttccag aggaacagtc
aggcagcaac atttgctgct 47340caccaatatc cgctgttctg cagccactgc tgctggtacc
caggcaaaca gggtctggag 47400tggacctcca gcaaactcca acagacctgc agcagagggt
cctgactgtc agaaggaaaa 47460ctaacaaaca gaaatgacat ccacaccaaa accccatctg
tatgtcacca tcatcaaaga 47520caaaaggtag ataaaaccac aaagatgggg aaaaaacaga
gcagaaaaac tggaaactct 47580aaaaatgaga gcacctctcc tcctccaaag gaacgcagct
ccttaccagc aacggaacaa 47640agccggatgg agaatgactt tgacaagttg agagaagaag
gcttcagacg atcaaactac 47700tccaagctaa aggaggaagt ttgaactcat ggcaaagaag
ttaaaaacct tgaaaaaaaa 47760ttagacaaat ggctaactag aataaccaat gcagagaagt
ccttaaagga cctgatggag 47820ctgaaaacca aggcacgaga actacgtgat gaatgcacaa
gcctcagtag ccgattcaat 47880caataggaag aaagggtatc agagatggaa gatgaaatga
atgaaatgaa gtgagaagag 47940aagtttagag aaaaaggaat aaaaggaaac aaacaaagcc
ttcaagaaat atgggactat 48000gtgaaaagac caaatctacg tctcattggt gtacctgatg
gggagaatgg aaccaagttg 48060gaaaacactc tgcaggatat tatccaggag aacttcccta
atctagcgag gcaggcaaac 48120attcaaattc aggaaataga gagaacgcca caaagatact
ccttgagaag agcaactcca 48180acacacataa ttgtcagatt caccaaagtt gaaatgaagg
aaaaaatgtt aagggcagcc 48240agagagaaag gttgggtaac ccacaaaggg aagcccatca
gactaacagc agatctcttg 48300gcagaaactc tacaagccag aagagagtgg gggccaatat
tcaacattct taaagaaaag 48360aattttcaac ccagaatgtc atatccagcc aaactaagct
tcatatgtga aggagaaata 48420aaatccttta cagacaagca aatgctgaga gattttgtca
ccaccaggcc tgccctaaaa 48480gagctcctga aggaagcact aaacatagaa aggaacaact
ggtaccagcc actgcaaaaa 48540cacgccaaat tgtaaagacc atcgaggcta ggaagaaact
gcatcaacta atgagcaaaa 48600taaccaggta acgtcataaa gaccggatca aattcaccca
taacaatatt aaccttaaac 48660gtaaatgggc taaatgctcc aattaaaaga cacagactgg
taaactggat aaagagtcaa 48720gacccatcag tgtgctgtat tcaggaaacc catctcacgt
gcagagacac acataggctc 48780aaaataaagg gatggaggaa catctaccaa gcaaacggaa
aacaaaaaaa ggcagggatt 48840gcaatcctag tctcggataa aacagacttt aaaccaacaa
agatcaaaag aaacaaagaa 48900ggccattaca taatggtaaa gggatcaact caacaaaaag
agctaactgt cctaaatata 48960tatgcaccca atacaggagc acccagattc ataaagcaag
tccttagaga cctacaaaga 49020gacttagact tccacacaat aataatggga gactttaaca
ccccactgtc aacattagac 49080agatcaacaa gacagaaagt taacaaggat atccaggaat
tgaattcagc tctggaccaa 49140gcagacctaa tagacatcta cagaactctc caccccaaat
caacagaata tatattttca 49200gcaccacacc acacctattc caaaattgac cacatagttg
gaagtaaagc actcctcagc 49260aagtgtaaaa gaacagaaat tataacaaac tgtctctcag
accacagtgc aatcaaacta 49320gaactcagga ttaagaaact cactcaaaac cactcaacta
catggaaact gaacaacctg 49380ctcctgaatg actactgggt acataacgaa atgacggcag
aaataaagat gttctttgaa 49440accaacgaga acaaagacac aacataccag aatctctggg
acacattcaa agcagtgtgt 49500agagggaaat ttatagcact aaaggcccac aagagaaagc
aggaaagatc caattgacac 49560cctaacatca caattaaaag aactagaaaa ccaagagcaa
acacattcaa aagctagcag 49620aaggcaagaa ataactgaga tcagagcaga actgaaggac
atagagagac aaaaaaccct 49680tcaaaaaaat caatgaatgc tggagctggt gttttgaaaa
gatcaacaaa attgatagac 49740tgctagcaag aataataaga aaagagagaa gaatcaaata
catgcaataa aaaatgataa 49800aggggatatc aacccgatcc cacagaaata caaactacca
tcagagaata ctataaacac 49860ctctacatga ataaactaga aaatctagaa taaatggata
aattcctgga cacatacacc 49920ctcccaagac taaaccagaa agaagttgaa tctctgcata
gaccaataac aggctctgaa 49980attgaggcaa taattaatag tttaccaacc aaaaaaagtc
caggaccaga tggattcaca 50040gctgaattct accagaggtg caaagaggag ctggtaccat
tccttctgaa actattccaa 50100tcaatagaat aagagggaat cctccctaac tcattttatg
aggccagcat catcctgata 50160ccaaagcctg gcagagacac aaccaaaaag gagaatttta
taccaatatc cttgatgaac 50220attgatgcaa aaatcctcaa caaaatactg gcaaaccgaa
tccagcagca catcaaaaag 50280cttatccacc atgatcaagt gggcttcatg cctgggatgc
aaggctggtt caacatatgc 50340aaatcaataa acgtaatcca gcatataaac agaactaacg
gcaaaaacca tatgattatc 50400tcagaggcag aaaaggtctt tggcaaaatt caacaaccct
tcatgctaaa aactctcaat 50460aaattaggta ttgatgggac gtgtctcaaa ataataagag
ctatctatga cataccgaca 50520gccaatatca tactgaatgg acagaaactg gaagcattcc
ctttgaaaac tggcacaaga 50580cagggatgcc ctctctcacc actcctattc aacatagtgt
tggaagttct ggccagggca 50640gtcaggctgg agaaggaaat aaaggttatt tgattaggaa
aagaggaagt caaattgtcc 50700ctgtttgcag atgacatgat tgtatatctg gaaaacccca
tcgtctcagc ccaaaatctc 50760cttaagctga taagcaactt cagcaaagtc tcagcataca
aaatcaatgt gcaaaaatca 50820caagcgttct tacccaccaa taacagacaa acagagagcc
aaatcatgag tgaactccca 50880ttcacaattg cttcaaagag aatacctagg aatccaactt
acaagggatg tgaaggacct 50940cttcaaggag aactacaaac cactgctcaa tgaagtaaaa
gaggatacaa acaaatggaa 51000gaacattcca tgctcatggg taggaagaat caatattgtg
aaaatggcca tactgcccaa 51060agtcctttat ggattcaatg ccatccccat caagctacag
atgactttct tcacagaatt 51120ggaaaaaact actttaaagt tcatatggaa ccaaaaaaga
gcccacattg ccaagtcaat 51180cctaagccaa aagaacaaag ctggaggcat cacgctacct
gacttcaaac tatactacaa 51240ggctacagta accaaaacag catggtactg gtatcaaaac
agagatatag accaatggaa 51300agaaataatg ctacctatct acaaccatct gatctttgac
aaacctgaca aaaacaagaa 51360atggggaaag gattccctat ttaataaatg gtgctgggaa
aactggctag ccatgtgtag 51420aaagctgaaa ctggatccct tccttacacc ttatacaaaa
attaattcaa gatggattaa 51480agacttaaat gttagaccta aaaccataaa aaccctagaa
gaaaacctag gcaataccat 51540tcaggacata agcatgggca aggacttcat gtctaaaaca
ccaaaagcaa tggcaacaaa 51600agccagaatt gacaaatggg atctcattaa accaaagagc
ttctgcacag caaaagaaac 51660taccatcaga gtgaacaggc aacctacaga atgggagaac
atttttgtaa tctactcatc 51720tgataaaggg ctaatatcca gaatatacaa tgaactctaa
caaatttaca agaaaacaac 51780aaccccatca aaaagtgggc gaaggatacg aacagacact
tcttgaaaga agacatttat 51840gcagccaaaa gacatgaaaa aatgctcatc accactggcc
atcagagaaa tgcaaatcaa 51900aaccacaaag agataccatc tcacaccagt tagaatggcg
atcattaaaa agtcaggaaa 51960caacaggtgc tggagaggat gtggagaaat aggaacattt
ttacactgtt ggtgggactg 52020taaactagtt caaccattgt ggaagtcagt gtggcgattc
ctcagggatc tagaactaga 52080aataccattt gacccagcca tcccattact gggtatatac
ccaaaggatt ataaatcatg 52140ctgctataaa gacacatgca cacgtatgtt tattgcggca
ctattcacaa taacaaagac 52200ttggaaccaa gctagatgtc caacaatgat agactggatt
aagaaaatgt ggcacatata 52260caccatggaa tactgtgcag ccatgaaaaa tgatgagttc
atgtcctttg tagggacatg 52320gatgaagctg gaaaccatca ttctcagcaa actatcgcaa
ggacaaaaaa ccaaacactg 52380catgttctca ctcttaggtg ggaattgaac aatgagaaca
catggacaca ggaatggaac 52440atcacatacc ggggcctgtt ctggggtggg gggatggagg
agggatagca ttaggaaata 52500tacctaatgt taaatgacga gttactgggt gcagcacacc
aacatggcac atgtatacat 52560atgtaactaa cctgcatgtt gtgcacatgt accctaaaac
ttaaagtata atagaaaaaa 52620atgaaaaggc aaattgtaaa gatagtttca acaaatcaaa
taaacataag gttagtattc 52680ttgtaagtat gaaatttaaa acagtgtatc catttaacaa
ttacttaatg tacatgaata 52740tatagcgtca ctagttatga gaataatgaa cgagattgct
tgctttagca catagttaca 52800actattcatt attcttataa ctagtgatgc tgagaatttt
ttgaaaaggc cattaatgat 52860ttgttcttct tttgttaaat atttcttcat gtacattaaa
taattgttta atggatacag 52920tgtttttaat gccaacaaat tagaggatca agatgaaatg
gacaaattcc tagaaagaca 52980caagttatag gaactgctaa aagaaagaac agaaagtttg
aataggtcta tgacaaataa 53040agaaatcaaa ttagcaattt ttataaaagc ccaggcccaa
gtggcttcac ttgtgaattc 53100tatcacacat taaaaaaatt attactagtt attcacaaaa
aatagaaaag gaaggaggat 53160ttctgagctc tttctgtgag ttcagtatta ccctgataac
aaattcagac aaagatgtct 53220agaagaaaag aaaactacag accaatgttg taggtagaaa
atcaacaaaa tacttgcaaa 53280ccgaatccag caatacagct tgaatatgtc ttatctgaaa
tgcttgggac cagaagtgtt 53340ttggatttta gatttttttt tttttttttg gattttagaa
tatttgcaga gtatacgctg 53400gttgaacata cctaatataa aaatctaaag tctgaaatgc
tctgatgaat atttcttttg 53460cacatcaggt tagcgctcta aaggttttga attttggagc
atttcggatt tcagattttc 53520aggttaggaa tgctcagttt gtttataaaa agatgaaata
ctatgaccag gtgggattta 53580tcccaggaaa tacaaggcta gtgtaacttc caaaaatcaa
tcaatgtaat acaccacatt 53640aatagaataa atgaccaaaa ccacatgatc atcccaagag
acacagaaaa agtatttgat 53700aaaatccagc atcccatcat tataaaaaaa ctcaacacaa
taggaatggc aaggaacttc 53760ctcaatttgt taaagggcat ctgtaaaaaa ttcaaaagta
atgtcatact tattagtgaa 53820agactgaatg ccttttccct atgatcagga atgagatgag
gatagctact tttaccactt 53880tgatttaaca ctatactgta gattcagggt agggaaatta
ggcaagaaaa agaaataaaa 53940ggcatttata ttggaaaata agaagtaaaa ttgtagtcat
cccgctgtat ccatgggttt 54000cacatccatg gattaaacca actgcagatt gaaaatactt
ggaaaaaaag ttgtgcttac 54060actgaacatg tacagacttt ttcttgtcat tactccctaa
agaatacggt ataacaacta 54120tttacataac atttacattg tattaggtat tataaatagt
ctagagattt taaagtatac 54180tgaaggatgt gcacaggtta tatgcaaata ctatgccttt
gtatatcagg aacatgagta 54240tttgcagatt ttggtatgtg tgggaggttc tggaactagt
actgcataga taccaaagga 54300tgattgtgta ttcacagatt acatgatctt gcatattaaa
aatcctaagg aattaataaa 54360aaaactatta gaactaataa atgagctcag gtcagttgca
gaatagaaga tcaatatata 54420aaaatcagtt gtatttctat acagagacaa agaacaatcc
aaaaatgaaa ttaaaaaaat 54480ttcattaaca atagcataac aaatttttag gaataaactt
aaagaagtgt aaaatgtata 54540cactgagaaa tataaaacat cattgaaaga aattaaggaa
acacctaaat aaatggaaag 54600atatctcata gaggacttca tatttttaag atggcaatac
tccttaattg atctgtatgt 54660tcaatgcaat tcctactgaa ttcctaaatg tctttattgc
agaaattgac aggttaatca 54720taaatttata taaaaagcaa agggacttag catagctaaa
acaatcttga aacaatacaa 54780agtttgaaga cttatacttc ctaattacaa aatttattac
aaaaggactg taatcaagac 54840aatgtgatac taaaggatga atatacagat taatggaaag
gaattgacag tctcaatata 54900atttctcaca ttgatggtga ttgatttttg atcagggtgc
caagacaatt catgggcata 54960gaatagtctt ttaaactaac agtgcgggga caactggata
tccacatgta aactaatgaa 55020gtaagacaat ctacttcaca ctatatacaa aaaaaaaaag
cttaaagtgg atcataggcc 55080tatatatgag agctaaactt attaaaactc caagaagaaa
cacagaagtc tttgtgtact 55140tagattaggc agtggtttct tagatatgac accaaaagct
caagtgacaa aagaaaaata 55200gttaagttag gctttatcaa agttaaaaac atctgtgtgt
caaagcacac tatcaaaaat 55260gcgaaaagac cacccacaaa tgggttccac aaaatggaag
caaatgtttg ggaatcatat 55320atctgataat tgtcttatct ccagaatata aaagaattct
tacagctcaa caagacaatg 55380acaacttaat ttaaaaagta ggcaagggac ttggatagac
atttttccaa ataagatata 55440caaatggcca aaaagcatgt aaaaagatgc ccaacaggtg
ggcccctgag cgggcgtccg 55500ggaccgtggt gtgccaggcg ccttccgccc ttaacatgcg
gtggctggcc caggcggtgc 55560aggagctgga gcggggcccg agtggggcgc cagagcccca
gcgcgagcag gagaggggcc 55620ggagcgcgga tccgcgccgc gctgctgaag cctggccggc
cacccagacg ctgccggcag 55680cctggccatg gcggagccaa ggaaagaatc tctatacaaa
caaatatgtg gctatcaaat 55740tggagctgat caagttccgg accccgcagc tgcacctggg
taccggttct acaagcagct 55800cagcgccata gagggcgtcc ctcaggtcta ctacctacta
cagcctggag gacctgttcg 55860accttcacgc ccaagacggt gctcctgatc gccatccggc
tgatcacgcg catggattat 55920gtgcacacca agaacctcat ttaccaggac gtgaagcccg
agaacttcct ggtggggcgc 55980ccggggacca agcggcagca cgccatccac atcatcgacc
tcgggctggc caaggggtac 56040actggtctca ggaccaagaa gcacatcccg tgcagccagc
acaagagctt gacaggtacg 56100gcgtgctaca tgagcatcaa catgcacctg ggcaaggagc
agagccactg caacaacctg 56160gaggtgctgg gccacatgtt catgtacttc ctgtgcagca
gcctcccctg gcaggggctc 56220aaggctgaca cgatcatgag cggtacagaa gatcggggac
acatagcgcg ccacgcccat 56280cgaagtgctc tgcgagaact tcccagagga gatggctacg
tacctgcact acgtgcggcg 56340cctggacttt gagaagcccg actgtgacta catgcggcgc
ctggactttg agaagctcga 56400ctacgactac ctgcggaagc tctccagcta cctcttcgac
cgaagcggct tcgtgttcga 56460ctctgagtac gaggggctcg ggaagccctt ggcgaccccc
atcagcagtg tccacaccga 56520cctgccctcc cagcctcagc ttcgggacaa agatcagccg
cacagcaaaa accaggcgct 56580gaactccacc aatggggagc tgaacgcgga cgaccccatg
gccggccact ccagcgccca 56640tcagggcgcc tgcagagatg gaggtgggcg atgaaacgaa
atgctgctgt ttcttccccc 56700tgaatcttct ccgtgcggcc ccttggggag cgagcttgtg
tgagggcctt ggggcccacc 56760cacagcggcc cagggccaga cgctggctgg aagccaggac
acagactgca gggtcttggc 56820cggcggcccc atccccggga cgaggggtca cttccttcac
gtaagactgg ccaaaatttc 56880tttttttttt tttttttttt ttttgagacg gagtctcgct
ttgtcgccca ggccggactg 56940cggactgcag tggcgcaatc tcggctcact gcaagctccg
cctcccgggt tcccgccatt 57000ctcctgcctc agcctcccaa gtagctggga ctacaggcgc
ccgccaccgc gcccggctaa 57060ttttttgtat ttttagtaga gacggggttt caccttgtta
gccaggatgg tctcgatctc 57120ctgacctcat gatccacccg cctcggcctc ccaaagtgct
gggattacag gcgtgagcca 57180ccgcgcccgg ccaagactgg ccaaaatttc tacacctgtg
tctagtcctc ccctccaaga 57240gcattaacta tttaaaacaa ggaataaagg aaaaaaaaga
aaggccccct ccacccccac 57300ccctccatta ctttgctgaa gtgagtagtg ggatcctgga
ggcccccagg gctgaggccc 57360agccagctgc ccccgttagc gtcataaagt ccagcttgtc
tccctcatcc aaaggccgtt 57420ttctcagtgg gagggcaggc ctggcctgga ggggtgctgt
ggggccatct tgcccaggcc 57480cacctgggag ggacacaggc attgctgcca ggggtgaggc
tgtgccccag gcctccccaa 57540aactaaaggg gaacggaggg gtggggccgc ggctgaagcc
agccccgcaa ccaaaatgct 57600gcaccaaagc tcggtcgcca caggcacggc caccgcagcc
tttcacagcc tggccccggc 57660gaggggcagg tgggccctgc taggagggtg cttctcgagg
cacctgttcc ccgaggctgt 57720gctccgaccc tcagaagctg aggggggtgg gccggctggc
gtcgcgcggc tcggcccctg 57780ggccctgctg tgtggaggcg cgcgggctcg tggcttcctg
tctctgtgct ccgccccctg 57840gcaagcagcc gcagacaaaa tgccttaaag cccccgaccc
agccccgcag gtgtatgtgc 57900aggggggtct gcgggcggcc ctggactggc tggcggactc
ccagcgggtc agcttgaggc 57960agtgcccagg gcggtggccg tgagtctggt ttttgcttta
ccaagtgtac ggaaatggcg 58020tttacgtttc tctgatgctc ttttgaagcc atacaactta
ggggctttaa aaaaaaaaag 58080gaaaaatgaa accctccgaa aaaaagatgc ccaacatcat
tggtcattag agaaatacaa 58140atcaaaacca cgatgggata ataataggtc tacaaggatg
gcaaaaatca gaaagacaaa 58200caataacaag tgttagagaa tttggactaa tttggatgca
gtatattgct gttgggaatg 58260taaagtggtg ctgctacttt ggaaaacagt ttggccattc
cttaaaaggg taaacaaaga 58320gttaccatat gactcagcaa ttctacttct agatatatat
gcaatagaaa tgaaaacata 58380tccacaaaaa cttgtacatg actcttcata ctagcgttat
tcacaataga aaaataatag 58440aaacaaaccc aaatgtctgt caggcgatga atggatacag
aaaaagtggt atattcatac 58500aatgaaatat taatttggca ataaaaggaa atgaagtaat
gatacatgct ctaatgtgga 58560tgaaccttga aaacattatg ctgagtgaaa gaaggcagac
agaaaggcca catgttctaa 58620aattagattg tgatatttgt acaatgctat gaataaacta
aaaacattga attttacact 58680ttaagtgggt ggactttatg gtatgtgaat tatatctcaa
taaaggtgtt actaaaagac 58740aatatagagt gttctttgtt tctctgaagg acaagttttt
aacttccatt tctccaaata 58800agcaattatt tgtttttata ccaaattagc attttcagat
tccctactga tgttactgga 58860ttaagctatg tttttaactt tttgttaatt tctacatttt
ttgtttccta ctattgcttc 58920tacattttgt gcactgaagg aggtagtata ttgattttac
acttacattt cttgtacttt 58980ctgcctatat tagtgttatc cacatatcct tttgtctcac
atttatattt aatactgtta 59040gctgtgtttt ctaagtatgg gataatacct ttcagtatgc
tgtaggtgac tatatataga 59100tagtacgttt gtatttgaac tatttggaag ctgaccaaat
gtttttatta tcttgtagat 59160tttactttcc tcgttggtat tgcagtggca gcaacagagc
ctatcggcat ggaatatctc 59220gaggtgctga agctcctctt cttgatgact ttgtcatgtc
ttacctcttt gctcaggtat 59280gattatatta tcttacttgt acatgagtta aatgataaat
atcttgctgt ttaataagtc 59340acttaatcag gaaaaacttt acatatggga aaattgcagt
tctgtcttgc acagcaggtg 59400cagagaagta acaaaattga gtcttttagc actagttttt
aatcccatgg tttatggata 59460atagaatcta ttttataaag tttttttgga ctgatccttt
tgaatttctt tcttttttag 59520gactttagat cattttaagg atttcgcaaa gtatagactg
aggtttacaa catgattcat 59580gtagacatac gtggctaaaa tattagtaac atttctttat
ggtttttaaa aaaatttttg 59640gacaatttca ggcttacaca atggacaatg aactgtagag
aaagtaggtt acataaaaaa 59700atgagctctg atagtttgtt tagctgttta taggaaggtg
actggatgtt gatacttagt 59760ctaagagcta tattcaagtt atttgttcac taatacagtt
atgtcaaatt tttgtattgt 59820gttggtattt cataatgctt tcttctctat taccttgatt
taaacagtaa ttgaaatatt 59880ttgtcattaa ataacttgtt tttatgtgct gctagactag
taggaataga aattaaagga 59940agaaaatata ttagtgctct tgggtaaaaa taggcacttg
gtatccccaa ggtatcagga 60000gttctaaatc agatttgcta atattgtagg aaacaagccc
acagatcctc atggctcgca 60060tttctgagag gaagcctagt aagcctagtt cagtttatga
acaacaaaag gaaaaacatt 60120tctctattgg ggtatgagac caacaaactt tatttttatt
gtggtaagag atatataata 60180aaaatgacca ttttaaccat tttaagtgta cagttcagtt
gtattaagta caaatacatt 60240gctgtacaac catcaccacc atccatctcc agaacatttt
tcatcttccc aaatggaaac 60300ttcataccca ttaaataata actctgtatt tcccactccc
aatggccttt tgcaatcacc 60360attctacttt ctgaatataa atctgccttt tctatgtacc
tcatacaaat ggagttatat 60420agcatttgtc cttttttgac tggcttattt cacttagcat
aatgtctgtc aggttcatcc 60480atgttgtagc atgtgccaga atttctttcc tttttaaggc
tgaataatat tccattgcat 60540atgtatactg cattttattt gttcattcat ctgttgatgg
atacttgggt tgctgctgtg 60600aacatgggta aacaaatatt tccttgagtc cctgttttca
gttcttttca atatataccc 60660agaaatggaa tcgctggatc atatggtaaa tttataattt
tttttgagga actgctacat 60720tgttttctgt agtggctgca ctatttttca gtcctaccag
cagtgcacaa gtgttccaat 60780ttctcaacat cctcaacaat gctttgcttt gtttgataat
agccatctct atgggtttga 60840ggtggtatca ttgtgatttt gatgcatact tctctaacaa
ccagtgatca tgagcatctt 60900ttcatatgct tgttggccat ctgtttatct tctttgcaga
gatgttgctt gttggctatt 60960tgtttatctt ctttgcagag atgtctactg aagtcctttg
cccattttta aatcaggttg 61020tttgtttgtt gttatattat agaaattatt attctggatc
ttaactcctt ataagataca 61080tgatttgtag atagtttttc ccattctcta ggttgccttt
tcattctgtt gcttgtcttt 61140tgatggacaa aagttttaaa tttggctgta ttctaattta
tctatttttt gtttcctatg 61200tttttggtgt catatccaag aaatcattgc caaatccaat
gttatgaacc tttctttctg 61260ttttcttgta agagttttat cattttagct cttacattta
ggcattgggt ccattttgag 61320ttaatttttg tctatcgtga aggtaagggc ccaacttctt
ttgcttgtga atatccagtt 61380ttcctagcac catttgttga aagactgtct tttctccatt
gaatggtctt ggcacctttg 61440ttgaaaatca tttgaccacc aacctacttt tttatacagc
tcctttatct gtatagccat 61500tatgaaaaga gaggggaatg gagagaggct tctaagaata
gccttttgaa aacaggatat 61560tatgaggtta caactttctg ttgcttttac gggtatatta
tttcacctgt gctgcagagc 61620tagtatattt tgggggtagg ctagttaagt cccatttata
agccaagttt tcccaaacta 61680ttcattcagc tactttagcc taatattaat actgcaatgt
ctagtatttt tgatctagaa 61740aaattttggg tgatttcaga atactcaatt ttatccttct
aggaaggatt gtcttatcta 61800gcatggcaag gtaattccac catataattc taaattatgt
ctagatagta ccacaagcaa 61860ttttctattt tttaatgttt ttacttctct aaatttgtgc
ccagaaaata tgatagtatt 61920tagattactc taagattgta ctgttatcat tttatattat
atgcatgttg tagactatat 61980atagcaaatg tgaccagtgg cattaccaga gtgtaagaat
atcttgacat ctttaaataa 62040ccaaaaaata gataagccac tgaactgtct ttaaagttct
taagacagta cctgtaggaa 62100gacagatttg gaaaaggtaa gcaaataaaa atcaaaagta
agatggccct tttaaattca 62160gtttcctctg ggaattaatt gcctttatat catcaaatat
ggctgctaag caaataaact 62220gctgacatgt gaacaacttt taattaattc atatctattc
aacaacaatt ggatgtttac 62280ctcatgttct tggcatcatt tctgattttg tgactgtgac
tgttttttat ttccctggct 62340aatgaagatg taaatttctt aagttcaaat tttgtcagct
actcaaatga gaaaaggttt 62400tctttcttat tttatttttt tatagagatt gaactcctgg
gctccagtga ttgtcttgct 62460tcagcctgtc agcctcctga gtagctaggt acaggtgtgt
gccactatgc ctggctaatt 62520tttttagttt tggttttgtg gagatggggt ctcgctctat
tgtccaggct ggtttcaaac 62580acctggcttc aaatgatcct cctacctcag cctcccaaag
tgctgggagt acgagtgtga 62640gccaccacac ctggcctgaa atttttcagt agttctaatt
aaatgaaatt tctgagggta 62700catactataa tatttaagga atagtattta ttatgttttg
gcatttgaga ctcttccatt 62760tgtaactttt ctctagtgaa tagtttatta tgtttttagt
attgccatca ctcatttttc 62820atatatttat tgtcttctga tcatgacttc catagaattt
ccacatgagc agaatttgtt 62880atctaccagt tcttttcttt tctttctttt tttttgagat
ggagtctccc actgttgcct 62940gggctggagt gcaatggcgt gatctcggct cactgcaacc
tctgcctccc aggttcaagt 63000gattctcctg actcagcctc cctagtagct gggattacag
gtgcctgcca ctacgcccgg 63060ctaatttttt gtatttttag tagagatggg gtttcactat
gttggccagg ctggtctcga 63120actcctgacc ttgtcatctg cctgccttgg ccttctaaag
tgctgggatt acaggtgtga 63180gccactgcac ccagcccatc tactagttct atagggaacc
aaggcaggct attaaaaaga 63240atctaccaag tcattgatca tcttctactt aaacagtata
acttacttgc ctgttctcaa 63300aagtgtggtg aaataagtgt ttaaaattga gcaaaaatct
gtctcctacc ctgaattaat 63360tttgtattag caacgtttag gcctttgttt tgggtgatac
tgattatttg atggtgtggt 63420tcttaatagt ttattttctt atatgaaaat atcttctata
ttttattaat agaaaagcaa 63480atatactttt aaatatgttt cttttaataa aattagttta
aaaaggttcc agtaaagctt 63540taatttcatg agacaagtta ttacatcaag agaagagaaa
tacagatgta gagtatagag 63600ggcccttgtc cggtttaaaa ccttgattcg cattgttatt
ttaggtaata tggctcttac 63660ctttttttct acaaagaaaa ttggtattat gtttagaata
tttgtacttc tgctttcttt 63720ttctttctcc cattacatgt tcagtcagat ttatctgtat
tcctaaatcc tccaggtcaa 63780aatcgtagaa cctctgtgtt tctctcttct tcattcttta
gacaatatat agttaataaa 63840gttatcagcc ttttttcaga atcttttagt atcttctgtt
tcctggatca gatccttatt 63900atttcgtatc tgagccatac accagcctct taaagagcct
ccgtaaatac actttatttt 63960cttcaagcac ttctatcatt gctactactc tgccaatgga
agagacatga tgaaaacaga 64020tctccatagt ttctaggatc aggtcattca agggtacctg
cagtcggacc ccaacttact 64080tttctaagtt ttaatccaca ttatttcttc acataaactt
caggccctaa tcaaattagt 64140ttatgcatct gaacatatct ggtgcttttg tgtgtgtgtc
attccttcta tttctttacc 64200ctgttttgtg tccatcatac atttctttat ttttaaacac
actgtgaagt ttcaaatctt 64260ccatgaaacc ctccttgatt actccagctg aatataatct
taactttctc caagttcctg 64320aaggagcttt tgtgtggtgc ttcctatatc atgtctggtg
ttataattat ttgcttctgt 64380ttcgcttcta agctaaattt tggtcccctt gatgactgag
accacatctt atacagtcat 64440gtgtcactta cttatgggga tatattctga gaaatatgtc
gttaggcaat tttattgttc 64500tgtgaatatc atgtattgta cttatacaaa cctatatgtt
atagcctagt atatgcctag 64560tctgtatggt atagcctatt attgctctag gctacaaact
tatatagcat gttgctgtac 64620tgaatattgt aggcacttgt aacacaacgg taagtatttg
tgtagttaaa catatctaaa 64680cataaaaaag atacagtaaa aatgcagtat tacaatctta
tggaaccatc gttatatatg 64740tggtctgcca ttgaccaaaa cattgttatg gggcacatgg
ctatttcttt gtatccaaca 64800ccacttgtag tatgatactt ccaacataat tggagttcag
tatatattta actcagtaat 64860atctacttta atttaggtaa tttttatgta gaagatataa
tttgaagata tatttaatga 64920aataggttga tgttatatgt actctgtaat tgggaaccca
gtgtaaatca gtttccattt 64980gcaaatgaac ttttattaaa attgtatcgc aaaatgaatg
aaaattaaag gaggaattta 65040tgccatttat ttatttatta atcattttag agactgggtc
ttggtctgtt acccagacta 65100gggtgcagtg gtgtgatcat agctgaagag atcctcctac
ctcagccccc caagtagctg 65160ggactgcagg tatgtgccac catgcctgga taatttttaa
attttttgtg gagatgagat 65220cttgccatgt tgcccaggct ggtctcaaac tcctgggctc
aagtgatctt catgccttgg 65280cctcccaaag ttctgggatt acaggcatga gccactgagc
ctggccaatt tgtatcttgt 65340aaatgcatat gttctgaaaa ttatgattaa aatataatca
tagattaaaa catgataatg 65400aaacttacga tgagatattt ccttcaaatt tttggtttta
gtggcggcat gattttgtgc 65460acggatggat aaaagtacct gtgactcatg aaacacagga
agaatgtctt gggatggcag 65520tgttagatat gatgagaata gccaaagaaa acgatcaaac
cccactggcc atctataact 65580ctatcaggta attttctttt gcaaatcctt acacataagt
gtgagtagag attttatata 65640attcgtatat attttctgtg tttacccatg ccttttgatt
ttgtaatact agttaagtac 65700tccttatcta aaatgcttgg aatcagaaat gcttcagatt
ttggatattt ccagattttg 65760gaatattggc attgaactta ccagttgagc acccctaatc
caaaatgctc taatgagcat 65820ttcctttgaa catcatgttg acgttcaaaa agttctggat
tttggaacat ttcgtatttc 65880agatatttgc aagagggata gtcaacctat aataaaaaat
catatgggta agttttatat 65940cttgggagta aaacacactt tgtaaggtga aattatttaa
agagttgtac tacaggaaat 66000atcataggta ttaaatatct attatttgat ttcatttatt
ctgagaaggc tagggaagtt 66060cagaggaaca gaagaaacac ctggaggcat actttttgat
agaagatcct ccagttggct 66120atataaatga cctgaataag tatttcccaa atggtggtgt
atattttatt tgcattagac 66180tcacgtgggg gagcctgtta aaatcaaaga tttctgggtc
ctaatccaag agatttggat 66240tcagtaaatc tgagttgaag cccacaaata tgaattttta
cagatgctct agggtattct 66300tatacaaatg gtccaaactc tgcattcttc aaattattct
tctgcatatt gaacttgaca 66360atcatggcta atataaaact gctttttaaa aaggtatata
taagaatggt ttaagtttga 66420aggcaaatat gtattttata tattacatac ttcccagatt
aaaaatttga gtacatcatg 66480agtgtggtta aagcttcctt ttttgaaatt gttctcccaa
taactggctt cagtcatttc 66540tttgccatgt catcaaaaca gttacatacc caatttgcag
agtatcaatt tctgtatttc 66600tctctttggt tttaaatatt cttgttttac tttcagatgt
ctgttaggtc ttaacctaag 66660ggtgtaggcc atagggtata attttaggaa ctcagaaatc
tagaagattc caaagcccaa 66720aggaaaaaaa aaacacattc attcattcaa cagctactta
ttgaatactt gctgtatgcc 66780aggctatagt agaacatagt tggaggaaga gtatcttaga
tgtcgttaca tagaaactga 66840aggaattcag gggaacacag ttgaagaaca gaagctttga
cccattgaag atgaatgtta 66900taaatatgaa gccatctcta gacttaagct atcgtggaat
atttctgctt tggaaaccat 66960gctgtcatcc aaagtcttgg cacaatcttt ctatgtagat
tgtagtttct tccagtttga 67020gaatcatgtc atctattgct cttatcccta cattatttag
tctagtgtcc taaacctaat 67080gactatttag taactattta tctgattctt ttaactcatg
ctcttagcca ggatataaac 67140acagatgcaa aatgctgcat catttttttt tactgcttta
ctttaaaaat agtgtagata 67200ttaaacattc atataagatt ccatgatatt ttaaaagagt
ttattgagat aatttacaaa 67260tcataaatct cacccattta aaatatacaa tttaatattt
tgtattatat tcacagggtt 67320gtataaagat gaccagaatc taattttaga acatttgcat
cctttctgaa agaaacccca 67380tgcccattag cattcagtcc tcatcccact ttcccccagc
ctctggaaac cacttatctt 67440tttgtttgcg tggattttcc tgtctcaaac atttcatata
aatagaatca tgcaaaatgt 67500ggtgtggcat tttttttgtc tggcttcttt cacttaatat
gatgtttcca aggttcattc 67560atgttgtaga atgtatcagt acttcatttc tttttattgc
tgaatcattt cattatatag 67620atataccaca ttttgcttat ttgttcttca cttgatgaaa
atgtgggctg cttccatgtt 67680ttggctattg tgactaatgt ggctatgaac agttgtatat
gagtaatttt gtggatgtat 67740ttttttcatt ttttcttgtg catatattta ggagtggaat
tcctggaaca tatggtaact 67800gtttaacttt ttgaggaact gcttaacttt tcaaaagcag
ctgtgccaca ttacattcac 67860actagcagta catgaagagt tccaactctt tccgcacttg
tttctgtctg tattttatcc 67920atcctagtgg gtggaagtgc tgtctcattc tagttttgat
gttcatttct ctaatgacta 67980ctgatgtttg gcatcttttc atgtactttt tggccatttg
tatgccttct gtagagaagt 68040gtctatttga attcattgct cattttttaa ttgggttatt
tgtcttttaa ttattgagtt 68100tagaaaattc tttttatatt ctggatacaa gtctccacat
ataatcatat ttatgatttg 68160ccattatttc ctcccattct gtgtattgtt attttacttt
cctgaaggta tcatttgtag 68220cacaaaagtt ttaattttga agtagtctaa tttgccccat
ttttctttgt gtcttgtgcc 68280atgtggaaat gtggttttag caacatggat gtctttcttg
gttttagcaa gagcagtttc 68340tcttgaaata atggaacaga agccaaactg gaatgagttg
agggataaat ggaaggcaag 68400aaaatggaaa tggctatgta catgctttca aaaagaggcc
agataggctg tggccagaag 68460gaaatgtggg attaagagat tttacatttt atacgggacg
gacattaatt tagcaagtcc 68520tttgtgcctg tggattctac atctaatatg ccacagaatg
aggtccagaa aggcttcctg 68580gattagatgg tacttgagcc ttgtcgaatg agtaactaga
taggagatgg atgattggaa 68640gaaagattag catatattac ggcatggaaa attatttaat
ggtacttcag aaataaaatg 68700ttccttagaa gcacagaaat aaattacctt ctttagaata
ttgtacatag agatgaatgt 68760acagaaaagt cagaatattt ctaaatggaa ttgttttgat
cacaaaggaa ttattaggag 68820ttgaagctgg cctaacaaaa taatatacag aagtatgttt
gcataatgaa aatggcttcc 68880aacaaaatgt aacaatttcc aaaattcagg taaatgttgg
agcacagcat cataggaaat 68940atttgtagca cagttcaata tatgccaaaa tattatctta
taaaccatta actctggtat 69000gtgaaataga gaaaaggaat ttttagagat tcttattaac
tagactgagg attcatttca 69060ttaggggaag aagattaaca tcttcttttg taaacattga
tgataactta gagtgtgtgg 69120atatatttat atcatcaaac aaaatcttaa agttttatac
tgtatggatg ggggttatgt 69180caacttacgc cacttggcca ctgtgttgta aggcctactt
aatcatggaa aaaggtggta 69240acttcttttt caatttttag atttatcttc caatttttgt
tttgttttgt ttttctgtat 69300gtgctttttt atccctagct acaagacatt cttaccaaaa
tgtattcgag caaagatcca 69360agactatcat attttgacaa ggaagcgaat aaggtacaga
tttcgcagat ttattcagca 69420attcagccaa tgcaaagcca ctgccagaaa cttgaaactt
aagtatctta taaatctgga 69480aactctgcag tctgccttct acacagagaa atttgaagta
aaagaacctg gaagtggtcc 69540ttcaggtgag gagatttttg caaccattat aataactgga
aacggtggaa ttcagtggtc 69600aagagggaaa cataaagaaa gtgagacact gacagaacag
gtaatcctta atgatatgtt 69660cttgttcttt gttattttaa gtacaatgga aataaaaaca
aagtaatttt aatcatttgc 69720aacatggtat tgcacttctc ccatttgata gaagtggaag
tttttaatag cgtgaaccta 69780tcaaggtcat ataattcttt gcctactatt cttaaatggt
tttttcattt aattttttat 69840gacaaaataa ttaccaatga ctatattata gtttcagaaa
gatgtcaaat tctaaaagtg 69900attttaaagg agttttgcct ttcactacta gtgataacag
aaggcataat tataaaactt 69960gttaactaga aaagattgat attaattgat tttatgataa
tatatacctg ctaaataatg 70020aatttatttt aggtttgcat tgcaagtttt gaatttgtta
atatccgtgt tgttcataga 70080ttgttactag agatttagag ggatcatttt ttaatttttc
atctttggta gtcacatttc 70140cagttttctg gcagtggttt ctactaatgt taattgaatt
gaagagtgcc atagcacatt 70200ttagattcct ggcatcattt aatgccctca tttttaagtc
aagcaagata cagcatagtc 70260ttagggttag attgatagag taaatcacgt ttaatgctta
tctattgtta tcaatacctt 70320ttttatttta aagaatttgg aaagaatgtt gtcttcttaa
gtcttgtttt aaaatggctc 70380tgtaaattct acccgttttt aattttacat gcttttaatt
ataggattta cagttatatt 70440gcgattttcc taatattatt gatgtcagta ttaagcaagc
aaaccaagag ggttcaaatg 70500aaagccgagt tgtaactatc cataagcaag atggtaaaaa
tctggtaagt ttgctttatg 70560attgaataat ggtttcattt tatagttctc agaaatgtgt
attttagaat cttagtacca 70620aaattatttt ctggtaggaa ttttgattgt agttttaaat
ataactctaa acatcagttc 70680agtaaacttt ttgataacat ctagcttttt gtattactat
caacaccatc ttcctacaga 70740gtttcttgta cattactgta ctttttttac tcatttttat
gattagcaaa gcaccagtta 70800ctttctcccc catccctact ctagattata ctagttctct
gatgtaatgc tcacccctga 70860ctaaaatatt ttatcaacag ggatgtatat gtgccagtta
tactgcctaa ttaaaggaga 70920aaaaataaat caatgatgtc tggaatttat ataacaaaat
gtaaatcaat cccaggtcag 70980ccccacccaa gctgtaggac atggttgatt ctaaaagatt
aacgctttct ctttttttaa 71040atagcttcag aaatctaatt tattttaatg taaataggag
aaatgaatta ttttatactt 71100tgctcttaag tttctcattt atcttctctg tcttcttttt
aactcagatg cttcttgacc 71160cttcctggct taaactagtc ctattaatgt tatttgtcta
tttatcttaa gtatttatat 71220ggcttacctg tctggctgtt ccagggttat attaccaaaa
ttgtaactaa cttgcaactc 71280acttaattca gcatagtttt ctgttcttag ataaaaatat
gatagtacac ctactgccta 71340gtagactgtg agccttttga aggtaaggat catattttta
tgtgtgtttg taccccctac 71400accttgcaca gtactcaggg cctagtttag aaaaagcttg
ataaatattt tatggatgca 71460taaaaggatg attaacaatt atcaacctca atgtggatat
ataataaatg tttctgggag 71520agtttattga tcttaatgtg aacaaactgt agtaacccaa
agaacttctc catgggactg 71580tatttggact tggcttaatt ttaagtctgc aatacagaga
agttaagtaa ctttccaagg 71640gcacagtgtt agttaagtgg tagggctatt taaactcaaa
tgcatgcttt gaaaacctaa 71700gctcttaagt gtgacactaa cttctttgct aagtatccgt
aaagctcctt aaaaatatta 71760tactgacatt ttgttggaat tgtgcaacaa actgggaaga
gttgacattt ctttctcata 71820ttaaattttt tattttaggg atacattgta tttctccttg
tatacaagta ttattttatg 71880tttttcagta attcttgatc attttattca tattgataca
tcatgtttct tgctgaattt 71940tattcatgat atgttatgct ttttctgttg tttattaaaa
ttaatacttc ttctctgtgt 72000attttcctac caaattattt atggatatag gaaagtaatt
tttgcttatt attgcatttt 72060cccagtgtat tatgtgttag taacattttg tttttactgt
cattttcctc ttcattctgg 72120catttatttc tctttataat tttggtaaaa tatatataaa
ataaaattta gcatcttaac 72180catttttaag tgtacagttt agtagtgtta agtatattca
cttttgcatc caatttccag 72240aactctttta tcttgcaaaa ttgaagtcta cacccattaa
ataaaaactc accatttccc 72300cctcttccca atccttgcaa ccagcattct actttctttt
tttttttttt tttttttgag 72360atgagtcttg ccctgtcatc caggctggag cacaatggcg
cgatcttggc tcactgtaac 72420ctgtgcctcc tgggttcaag caattttcct gcctcagcct
cccgatagct gggattacag 72480gtgcacgcca ccatgcttgg ctaatttttt gtatctttag
tagagacggg gtttcaccat 72540gttggccagg ttggtcttga agtcctgacc tcatgatccg
cctgcctcat cctcccaaag 72600tgctgggatt acaggtgtga gccactgtgc ccagcccctc
tactttctta ttctatgaat 72660ttgactactc tagatacctc ataaaagcag gctgaaacaa
tactgtcttt ttgtgacagg 72720cttatttcag ttagtataat atactcaagg ttcatttgta
ttacagcatg tatcaatttc 72780cttcattttt aatatatgta tgtattctgt gtcatgtata
taccacattt gttcattcat 72840ccatcaatga atattcaggt cactttttta ctttttgaca
attgtgagta atgctgctgt 72900gaacatgggt gtacaaatat ctcttgaaaa ctctgctttc
aattcctttg gatatatacc 72960ttctattagt ccgttctcac actgctataa agatactacc
tgggactgga taatttattt 73020aaaaagaggg tttaattgac tcgcagttcg gcatggctgg
cccaggaaac ttaaaatcat 73080ggcagaaggt gaagggcaag gaagccatgt cttacatggc
agcagaagag agacagtgtc 73140caggggaaag tgccactttt aaaccatcag atctcatgag
aactccctca ctatcatgag 73200aacagcatgg gggaaacaac ccccatgatt cagtcacctc
ccaccatgtc cctccctcga 73260cacatgggga ttacaattaa agatgagagt tgggtgggga
cgcagagcca aaccatgtca 73320tacctagaag tagaattgct ggatcatatg gtaattctac
ttgtaatttt ttagggagcc 73380accatgctgt tttccatagc agcggcacca ttttacattc
ctaccaggag tacattctcc 73440acatgctcat caaaacttgt tattttctgt tttctgatag
tagccatctg atgggtgtga 73500agtagtatct cattgtgatt ttgattcaca tttccctaat
gattagtgtt gctgagcgtc 73560ttttcatata tgtattgcca tttgtatatc ttctttgaag
aaatatatat tcaagtcctt 73620tgctcatttt ttaatcaggt tttttttgct gaattataga
aattatttat gtattctgga 73680tattaatccc ttttcaaata tatgatttgc aaatattttc
tcccattcca tagattgctt 73740ttcactatgt tgcttgtgtc ctttgatgcg cagatgtttt
aaagttttag ctagttcaac 73800ttttgttgcc tatttttctt tttactttgt tgagatataa
catgaaccca gtaaagcaca 73860ctaatcttac gtgtatagct caatgaattt ttacatattt
gtacatcttt gtagccacac 73920ccacctcaaa aaacagaata gttctcttac tcctagaagg
tttccacatg catcttccca 73980catattcacc tccaccccta acttaagata cctatcatct
accatcactt agttttatct 74040attaataaag gttgtataaa tggaatgata ctgtatgtat
tcttttaaaa tctagattct 74100tttagttagt ataatgtttg gagattcatt tatgttgtta
catgtgtcag ttcattcctt 74160tttattgctg ggtagtattg aattgtttga ctgtacctca
aattttaaat gtattctgtt 74220gatggacatt tgggttgctt tcactttggg gattttaggg
ataaatttac catgaacatt 74280cttatacata ttttttggtg gacttatgca ctcttttttt
gtatatatat atcctagaga 74340taggattatt gagtcatagt gatagcttta gtatactgcc
aaacaatttt ttgtagttct 74400atcagttcac tcttctttca gtaatgcatg aaaattacag
ttgtctcata tccccatcaa 74460ctcttaattt tgtcagtcta aaaatgtctt agtttgtctg
gtggatgtgt actggtagct 74520attgtagttt ttattttcat tgccctggtg agtaatgatg
ttcaatactt tttcacttac 74580ttattgttca tctgaatatc cttcttatga agtgcctgtg
acagtctttt gcacattttt 74640cattgacttg tccctttctg atcaatctgt agagtctcta
tagattctaa gtcttttgta 74700ggatgtttgt aaaacgtata tagacatacg tcagagatat
ttctagttca gttctggacc 74760actgcaataa agcaaatttt gcaatgaagt gagtcacata
aattttttgg tttctcagta 74820catataaaag ttatgtttac actataatca agtctactaa
gtgtgcaaca gcattatgtc 74880ttaaaaatta atttaaaaca ctttattgct aaaaaatcct
aatgataatc tgagcctcca 74940gagagttata atctttctgc ttatgagggt attattttga
tgttgatggc tgctgaccga 75000tcagtgtggt ggctgcttaa ggttgggttg gccaaagcaa
tttcttaaga taacaatgac 75060atttactgca tcagtagact cttcatttcg ttaaagttgt
ctctgtagca tgtgacattg 75120tttggtaaca ttttacccac agtagaattt ctttagaaat
gagtcagtcc tctcaaaccc 75180tgccactgct ttatgtacta aactttattc taaatccttt
gctgtctttt caacaacatt 75240cacagcatct tcacccagga ctagattcca tctcaagaaa
ccattttttt atgcataaga 75300agcaacttat ctgtccaaat tttatcatga gattgtagca
attcagtcac atcttcagct 75360ctacttctaa ttctagttct cttgctattt ctaccacatc
ctagtgactt cctccattga 75420agtcgtgaac ccctcaaagt catccatgag ggttggaatc
aacttcttcc aaattcctga 75480taatgttaac actttgacct tcttccatga atcactgatg
ttcttcctgg catcaagaat 75540ggtgaatcct ttccataagt ttttctattt acccagctcc
atcagatgaa tcactatcta 75600tggcagctta gccttacaaa atgtatttct tagataataa
gacttgaaag ttgaaattac 75660tccttgaccc atgggctaca gaatggatgt tgtgtcacca
ggtctgaaaa taacatgaat 75720atccttgtac atctctgtca gagcgcttgg gtgaccaggt
gcgttgtcaa tgagagtaat 75780actttgaaag caatcttttt ttctgagcag atcttaacaa
tgggcttaaa atagtcagta 75840aaccatgcta taaacaatag atgtgctgtc atccaagcct
tgttgttcca tttatagagc 75900acaggcagag tagacttagc ataattcgca gagccctggg
atttttggaa tggtaaatga 75960gcgctggttt gaatttcaag tcaccaatgg cataggccct
tagcaagagg gtcagcctat 76020cctttgaagt ttgaaggcaa gcactgactt ctcctctcta
gctgtggaag tcctagatgg 76080catattcttc caacagaagg ctgttttgtt tacatttgaa
aatctgtttg ttagtgtcac 76140catcttcatc aatggtcctt actagatctt ctggataact
tgctgtagct tccacatcag 76200catttgctgc ttcaccttgc acttatgctg tgcacatggc
ttcttttctt aaacctcatg 76260aaccaacctc tgctagcttc caacttttct tctgcagctt
cctcacctct ctcagccttc 76320atagaattta agagcattag ggtcttgctc tagattaggc
tttggcttaa gggaatgtta 76380tggctggttt gatcttctat ctagaacttt ctctgtatca
tcaataaggc tgttcacttt 76440cttataattt atgtgctcac aggagtagca ctttcagttt
ccctcaagga cttttccttt 76500ggattcataa cttgcctttt tagtgcaaga ggcctagctt
tcagcgtgtg ttggctttca 76560gcatgccttc ctcactaagc ttaatcattt ctagcttttg
atttaaagtg agagatgggt 76620gaatcttcct ttcacttgaa tactcagtgg tcattgtagg
attattaatt ggcctaattt 76680cattattgtt gtgtctgagg gaatagggag gcctgaggag
agggaaaaag aaagggaaat 76740agctattcgg tggagcagtc agaacatata caaatttatc
acttaagttc accatcttat 76800ataggcccag tgtgtggtgc cccaaaacaa ttacagttga
cccttggaca tcacaggttt 76860gaattgtgtg ggtccactta tatgcaattt tttttcagcc
aaacatggat ggaaaatata 76920gtattcacag gatgcaaaac ctgcatatgt gtagggctga
cattttgcat atatgggttc 76980tgcagggctg atttcagaac ttgaatatgt tcagattttg
gtatatgcag gggtcctgta 77040actaatcccc cttgtattct gagggacaac tgtacaatag
ttacatcaaa ggtcattgat 77100cacaaatcac cgtaacaggt ataatagtaa taaagtttaa
attttgtgaa aattaccaaa 77160acatgacaca taggaagtaa gcatatgcta ttggaaaaat
tgcactgata gacttgtact 77220tgctccactt aagtttgtca gaaaccttcc atttgtaaaa
aaaaaaaaaa aaaaaaaaaa 77280aaaaaaaggt catatctgca aggagcaata aagggaagtg
cagtaaaaca aaatgtgtct 77340gtatatcaat aagagggata ctagttagtg aactgctagt
tcaaagggta tgaatattta 77400caactttgat agattattaa aatacttctc aaaaggtgtt
tccaatgtat ctgtacacct 77460gttttcttgt atcctttgcc aacactggat gttatcaatc
ttttaatttt tctgccaaat 77520caatgggcaa aataatgctg tcctgttata tttcatttcc
ttaattagaa cctgagattg 77580agcaatacct catgtgttta taggtcagct ttaatattta
tacttctgtg gattgccttt 77640tcatgtcctt tgactagttt tcttttttta tttttaattg
ttttatacgt tttattccca 77700caatgtatgt taggtatatt cctttgttat acatgtttgt
aatctccaag tcttttaatt 77760ttgtttagga taccttttat agtacttgtt tttttggcta
tttgtgttag ctaaatacct 77820tttatagttc aaacatgtca catgcttgtc tctttattat
aatttttggt tgaggactct 77880attctgtgtt ctctttatga ttatgtaaat attgttcatt
gctgggccaa gaaatatgct 77940gtaatcacat tttcgttctt atataacttt ttccaggagt
taattattgc tttatgattt 78000ttcctttgta tctagcttta ttttcatttt ctacaagaac
tctgtaaagt agtggacttc 78060tcaatacaaa atttcacata atcaaacctg tcatatatga
tagcattttt acttcttttc 78120tggagaagta cctcttcgat cacagcatct tactttgtag
tgtggactgg aagttttctg 78180ggtacagcta ttattttgtc agctgtaatt tttggtcatt
cctttcttat cctggtaact 78240atgttttcat ctctcttata ttggatctga ttttctaaat
ctcatgtttg ccctgttttt 78300ctaggtacag cctctggtat ttgttggtat ctttaatgtg
attgagacaa attagaaaat 78360taatttagag aggattttta catttttatg atattgaatt
ttcctaccat ggttaatctt 78420ctatatattt aaataaaaag ttgcataaga gtgttttgaa
gtttttgtta attattgata 78480ttgcatcctc tttgttacaa atggggcttt tttcattata
taactgactt tttgtatgta 78540aaaatataat acgtctatat attttcccat gtaagtaaca
tgctgcattt ttggctgact 78600acatgttcac atatgtatta agatacaatc aggccgggca
tggtgactca cgcgtgtaat 78660cccagcactt tgggaggcca aggcgggcgg atcattaggt
caggaatttg agaccagcct 78720ggccaacatg ttgaaactct gtctctacta aaaatacaaa
aattagccgg gcgtcttggc 78780gtgtgcctgt aatcccagct ttttgggaga ctgagacagg
agaatcgctt gaacccagga 78840ggcagaagtt gcagtgagcc aagatcgcgc cattgcactc
cagcctgggc gacagagcaa 78900gactctgact gggcgggggc cacaaaaaaa tcatagcata
gctacatatc ctaacatttt 78960agtttgtagc atgaatactt tagcagtatg taattggtat
gtagggctga tgccgtggct 79020cacgcctgta accccaacac tttgggagac tgaggtgggt
ggatcacttg aggtcaggag 79080ttggagacca gcctggccaa catggcgaga acctgtcttt
actaaaaata caaaaattag 79140ctgggcatgg cggcatatgc ctgtaatccc agctactcat
gagggtgagg tgggtggatc 79200gcttgagcct gggaggtgga ggttgcagtg agccaagatt
gtgccagtgc acttcagcct 79260gggcgatgga gcaagactct caaaaaaaaa aaaaaagaaa
aaaggaaatg ctcatgattt 79320ctaatgtcaa cttttatatc atattaaata gatttctagc
tgagataact ggtatattag 79380tctaagaagg acattggaaa ataaagtaaa atgatggcta
tagagtgaac tataactggg 79440aaggtatgat aatctgtatt taggaggatc ttaaatatca
gacatgagaa tttgtaattc 79500atattgagta ctgagccata aaagatatga gcaatttaga
agaaaattgt atttaacatg 79560gaatgaagaa aattttcaat atttaacatg gagttgactt
tctaaaaggt gctatttctt 79620tttcttttct ctgcttagga aattgaactt agctcattaa
gggaagcttt gtctttcgtg 79680tcattaattg atggatatta tagattaact gcagatgcac
atcattacct ctgtaaagaa 79740gtagcacctc cagccgtgct tgaaaatata caaagcaact
gtcatggccc aatttcgtga 79800gtaatacaga cttaaaagta aatttttaga aaagtaaatg
ctgtatttac aaagaagatt 79860taacagagtg atacatgtat gtttagaaaa aaataatttg
acaagttttt tttaaacaaa 79920aggctatttg caatcagatt acataataat tagaattatt
tagtgtataa tttaccatct 79980gtatcccaat ctataatatt tataagttgt acaagtttaa
catttgttaa tcatgcctat 80040gtgtgattca ctcctgcatg ttactaaaaa agaaagatct
ccaatttatg ttttattaat 80100tttaaaatac tgcaaggaag ccacagtgca aaatttgaaa
attctttatg tttggatagt 80160ccatctcctt ctactgaaag gttcaaacac aagatatata
tgatgtccac atttctagac 80220tagtgctatg tagaacttcc tgcagcgatg aaaatattct
atatctgtgc tgtgtaacac 80280agcagccact agctacatgt ggctgtttag catttgagat
gtggctaatg caaccgagga 80340actgaatttt aatttaattt taatttcttt acatttaaat
agctacatgt ggctagtaac 80400tatcacattg gctcacacag ttgtagatcc ttactttaat
actgggtaaa gctagctatc 80460atgcataaca tctatttagc ttaagtccta atgatctctt
agctaggatg tggtttatgt 80520tgacaacaga tttgaataac tcgagcaaag ggaaaatctg
ggatcatgag catattatgt 80580tctttgcatt taacctaccc ctaaatattt gagaaaatac
atcttgggta atataaagag 80640ttgatttagt ctatgcttaa tatttattta gtaatgaata
ttgttgctat gaaaaagttg 80700tactacttga actttatgtc tgtaatttac atgtttaata
tttttaaaac tccttgcctt 80760tattcatgta tccataaatt cattcaaaca ttcttttatt
tatatttact gagtaactac 80820tatgtgcaag cattggtttg tatattagaa atatggtgat
aagtgaaaca gaatgattct 80880ttcttttgta tagattatat tttgcttttc tttcagggtg
tgcagcttca gaaaacataa 80940aaaattttaa aaaccagtag tctttgtcag ttgccatggt
tcttctctta gactttgtta 81000tcgtactgaa taataaaatc atgcattcag atttttatgt
cagtaactgc tatggtagta 81060gagatataag tattttctga tatataatct ttatagttaa
atgaaggttt ctgagagtat 81120ggttttaaaa atattaactt tgtaatcagc aggcagaaaa
atcaaatgaa caaattgttc 81180tttgtgattt tgtcttataa atacctttta ttggttttta
aagctatata attgtccctt 81240gaagtggttt gaacttactg caaaatagct tggtactttg
attttttcct ttgaaagatt 81300attgctaaac atataaagta gaggagacaa ttctgacagt
tttagatttg acttttgatt 81360gttttagatg acacttggtc ataatattat ggtgcttgat
atattattca aattgcttct 81420tctttacctt taggatggat tttgccatta gtaaactgaa
gaaagcaggt aatcagactg 81480gactgtatgt acttcgatgc agtcctaagg actttaataa
atattttttg acttttgctg 81540tcgaggttag tatgtcacac ttattagtgg taacacttta
tttagttcat ttaatttcct 81600ctccatattt atttaccata tttccttttt aatactgaga
attatagctt tggatatgat 81660aactagtata atgcttaatt tcctcagaga ttctgtacaa
ataaacaagt tataattccc 81720agggtttata taaaaatata aaataattta taatgtctat
ctttttattt tgcatttatt 81780ttattttctg atgttttggt gttaccagtg tgttaaaagg
tatttcatca agtgtcttga 81840tgtttctttg tttgcaaaac tggaaatctt tgccacatca
tgtagaacaa aataaatcgg 81900aagcaaattt tctgtttatt aacagtggtt gcagaattag
aggaaacaga attagagaaa 81960actaggtcaa taacaaacaa atagaaacat taaagcactt
ttaactgatg attttctaat 82020atttttaaga atagtggtct acaatgcatg tttcaacggt
aaaactgcaa tgaaacccca 82080ctgttaatac agatcatttt ggatctcatc tatgattata
tactatcact tatgaggcaa 82140tttcatggta taaatcctaa gaaactatag aagcttgcaa
atttatcttg cttttttaaa 82200acagagaaaa ataagaactt tgttattcaa ttattttaat
ttttataaaa tgcaacttat 82260atttggcata tgtagagggt agattactta cagaagggag
gttatgccat cactttacct 82320ttgtgtaaaa ctggtaatct atcctaattt caaagtatcc
tgttactata acagataata 82380gtacattata ttcaagtatg aattcaaaaa aatatatata
tatattttat gttcactgta 82440tgtgccaagc ctaatatgag agctatgtat tatagagttt
atgctacagc cctaccttca 82500ggaaacttat ctactggaca aacaaaaatt ttcaaatata
caaaaaattc taaatcgaac 82560attgtaatta tctagcatag gcaaatatag acagtaacag
acaggtttac aattattaag 82620aaagggcagc caggtgtggt ggctcacacc tgtaatacca
gcactttagg aggccaaggc 82680gggtggatca cgaggtcaag agattgagac catcctggcc
aatgtggtga aatggtgaaa 82740ccctgtctct accaaaatta caaaaattag ctgggcatgg
tggtgcgcac ctgtagtccc 82800agctactcgg gaggctgagg taggagaagc gcttgaaccc
gggaggtgga ggttgcagtg 82860agtcaagatt gtgccactgc actccagcct ggcgacagag
cgagacacgg tctcaaaaaa 82920aaacaacaac aaaaaaaaaa aaaaacaaga aaggttattt
ggcataggaa gaacctgatt 82980gaccttgagg tattggtaga ttttatataa atgtttctga
gtagaatgaa tatgtttata 83040aaatgcacct taaaaatagg tgaacaagtt cataatatag
tgcataagac aaatatttaa 83100aaactgcaaa atattaaaaa tgtaatatta aagataatta
tacaaataca atggtggtgc 83160agtggaatgg ctgtatgttc acctttgctt gtgcaaagag
gtgagcatta gagaggacct 83220cttagaaaca gtggtacttg aactgagttt tgatgaatga
ataaaggttc attgctcaga 83280agaagtgggt atacattctt aggtagaaag atagcatgaa
gaattatcaa ggcatgaagc 83340agcatggcat ttgcttgaaa tgatttaagt catttaatat
ggctggaacg taggttgtat 83400gttggcagtg gcaggagctg agattggaga tggaggcaga
aaccagctca tggaaggctc 83460tatatgctac atttgtttta ggctttatct tataaatgat
ggaaaactat taaggatggt 83520attgttgcta ttaattatca ttgccttctt acatgctttt
tcataaaatc aacttttaaa 83580ccacttttgt aggctgagaa attgtaaatt gcccttttga
ggaactaagt acttctatca 83640ctatactggc actacatcgg attcatggtt caaatgttta
ttctgttgct tgttcttgtg 83700atatcatttt gtcagaataa tcactgtgat gtccattgtg
actatccctc cctttcttta 83760taattaaact tatacagcga gaaaatgtca ttgaatataa
acactgtttg attacaaaaa 83820atgagaatga agagtacaac ctcagtggga caaagaagaa
cttcagcagt cttaaagatc 83880ttttgaattg ttaccagatg gaaactgttc gctcagacaa
tataattttc cagtttacta 83940aatgctgtcc cccaaagcca aaaggtaaga taattttcta
gttattttta aattactggt 84000catggattgt ttatgtggcg tgaagtatct tcagtacatt
gatttcaaag gatatatgaa 84060agaagcagct ctaaaagtta attttatctt attctattgt
acaagcatca tcaaataaga 84120ttgtttactt tggttttggt ggtctagaag tgacttgaag
ttcaattatt ctaaaatgag 84180attttaaaca taatgtgtgg tatgatgtca tttattgaac
tggaagatct cactactaaa 84240ttcttatgtt gttttaagta aaaattttca tatacttcga
ggattttaat ttctgtattt 84300taaaaataaa gacagtaaag ttggaaattc cttgaaataa
tgagccttac tattaaaaat 84360tattaaaatt cctgaaaaat tgtatgagtt aaggaagtta
ctataatttt gaattaatga 84420aataactggc aggaatacat caaaatccaa attacattag
ttaaggaagt gattataatt 84480ttgaatgtat gaagtaacta agaagaaata tcaaagttca
atgagttgac ccctaaaata 84540attttctatt ataaaaaaag aacaattagg agttattaag
catttcttat acgtagaaca 84600catttcattt tactcctctt tggagcaatt catactttca
gtgtattttg aagtgatata 84660tatgtatttt attttttcag ataaatcaaa ccttctagtc
ttcagaacga atggtgtttc 84720tgatgtacca acctcaccaa cattacagag gcctactcat
atgaaccaaa tggtgtttca 84780caaaatcaga aatgaagatt tgatatttgt aagtcattag
atactcatta ctgtcttttt 84840tgtcctttta aaacaacatc tgttttcttg atttacattc
atgtgacatt ggaattattt 84900tgttatatac aaatttagtt gtgatttaaa tatttttctt
atgaaaaata tgccaacctt 84960gtgttagatg ttagcaaaat taattatctt aattatccta
agaatggaat cttaattttc 85020tttttggaaa tttaaaaatg attcttcaca aatctcaaat
taaaaattaa aaatctacaa 85080agacctatat cgcaactccc aagttctcaa gaaagtaagg
gaaattcaag gggttaaaaa 85140taaagaagaa actgagaaaa aaatccagcc atctctcagt
gtccatgagg gattggttcc 85200aggactaccc atggatacca aaatctgagg atacttaagt
ggaacctgtg gatatgaaaa 85260gttggccctc tatatacatg ggttttgcat cctatgaaca
ctgtatttct ttttttaaat 85320aactaattat tttttaaaat tatttattta tttattagag
caggacttgc tgtgtcaccc 85380aggctggaat gcagaaatac tatattttcc aactgagttt
ccttgcagat gcagaacccg 85440ccctgccagt acagagggcc cactggattt attgaaaaaa
acccacatat aaatggacct 85500gtgcagtcca aacccatgct gttcaagggt caactgtagt
acataagatc tgataatctg 85560gcagtcaggt ggtgagggtt gatgatcagc cacatttatc
aagggggtta agatttaaga 85620gcaatttaaa agggccaggt ctcagacctg tgcaaggcca
cgagttaaaa gtgagactat 85680ccctgagtaa aaccaggaca cttaagtaaa tacatcctca
gtaaaacaat atatagaatg 85740tgaaaaattc acccactagc aagcagagaa gaaaaggaat
attgtcattt ttaactgcgc 85800ttctggtgag gaaaaggagt ctctcctaag aatttgtcat
cataagcttt ggaatttggg 85860cttcattata ctacctacat agactgagaa atcctaaatt
aaaagtggta ctctcctaat 85920attgtgtggt gcttggaaga aacaaaaaaa tcttttcgga
accacatact cttaacctag 85980gcaacccata attcccacag ataaaagcat tgcaaacaca
agcttttaat agaaaattta 86040gaaacataca aggaaataat gcaggattaa ttaagagtca
gtagaccaac aaacatcaaa 86100attagaactc caggaacttc ctatcacaga attttcagat
acagactata aaatacatat 86160acatgtttaa agatagaaaa ggaattgaaa ccacggagaa
ataacaagac attgttttaa 86220caaacaaaaa agatgtcagg aaaaaggcat agaaatgata
aatatcctca ttgacattaa 86280aacagaatat acaggatgaa aagtaaatta cttatagctg
aagagagatg tagtgaacct 86340caagacagat ctgaagaaat taagaatgca gcagttaggg
agaaagaaat ggattatatg 86400aaagagggat taagtggcat ggaaggcaaa atgagaaaga
cccaactcat atctgagctc 86460tataaggaga caatagatag aattagccag aatggtaaag
acaagcatct tcatgtgagt 86520aacaggaaac agagtggcca ggtaacttga ctaacattac
aaatctaata aatagtagac 86580cttggatttg aacacaagca gccttactgc agagtgcagg
ctttcaacaa ttactttgta 86640aagatatgca agaaatacta gtattagtag taatagctga
tacttaatgc acatttacta 86700tgtgtcatgg actgtgctaa gtgcttttat gtatttattc
acttattgat cataacaatc 86760ctatgggaaa atagttatta ttctcatttt tcagatgaag
aaaccacgac agctgcagca 86820cagagattaa atagcctgta caaggtcata caagtggtaa
taagagaaag tcagatattc 86880tgcctctgca gaccacattc tctagtgtgc tagtaggaaa
ggcaaagaaa atgattccca 86940tgtaagcaaa tgtaggtaaa cactgactct atttttaaaa
agtgacaatt atagcccatt 87000caggagattt caaaaccgag tagagccaaa atacacttaa
ttcattaatc cttgttttct 87060gtctcttatt actatttaag gaagcagaat aaaagcatta
atttggagtc ttaaatctgg 87120atttagattc taaggaaaat acttgcttat ggatttaaaa
aaattcttcc tcattgaatg 87180tattttcttg ttcctacttc gttctccatc tttactcatt
cttttctttt acctttttct 87240cttgaagaat gaaagccttg gccaaggcac ttttacaaag
atttttaaag gcgtacgaag 87300agaagtagga gactacggtc aactgcatga aacagaagtt
cttttaaaag ttctggataa 87360agcacacaga aactattcag aggtgtgtat gttctttata
ttgttcatgt agtttatgct 87420gtttaaagat gtgctctcat atgcatacaa cgtactcatg
tgtgcagctt ttcaaaattg 87480taatttttaa atgtgtcaag gacttttctg aggatacatt
cttgtggggc tatagaatta 87540cagggtttga aaattaccgg attaaaaaaa ttaattccaa
actaattatg tttagcatta 87600tgttaggagt gttattacat ttctgcatat actgtggcct
tgattttcaa acttggctcc 87660ccagagcttt atgggttaca cagaggctcc tctacaatta
catttatttg aaaaaaaaac 87720aaaaaaccaa gtttcaaagg cactgtacta aggaacatgc
ttagtgaaat ctagatgcct 87780ctgggcatca tccagagatg ctagctggca gaccccgtgg
ccagttgcca gagctctgaa 87840catagcaaga tatgatactt acaatatctt aaagggtgtt
ggtgttagaa gatgatgtga 87900aaagttcaag ccaaagagtt gttctaatcc agaataccac
agtattggtg attgtgattc 87960actaatcata cccaggggtt ctagtcacag tttagttgaa
ttagagtgat gttaaaacta 88020tgctagtatc ctgacacaga tgtcgtgata ttttatctgc
acattcttaa ttctttagca 88080agtgttattt aaaggctaca tccatctacc tcagtttcct
atatctatct ctgacatcta 88140cctctagttg tacttctgtc ctctatttca ggtgttatgg
gtcaagcctg tttgactggc 88200attattcatg attcctgtac cactcttgct ctctctcact
ttgatctcca tattccaggc 88260ttacacaggg gtttcctcag aacgttgatg gcagttgcag
gtccatataa agggaccaaa 88320gcacattgta tcctcatcta tagtcatgct gaaagtagga
gaaagtgcat ctttattatg 88380gcagagagaa ttttctgaac tatttatgga caacagtcaa
acaacaattc tttgtacttt 88440tttttttcct tagtctttct ttgaagcagc aagtatgatg
agcaagcttt ctcacaagca 88500tttggtttta aattatggag tatgtgtctg tggagacgag
agtaagtaaa actacaggct 88560ttctaatgcc tttctcagag catctgtttt tgtttatata
gaaaattcag tttcaggatc 88620acagctaggt gtcagtgtaa actataattt aacaggagtt
aagtattttt gaaactgaaa 88680acactgtagg actattcagt tatatcttgt gaaaaaggaa
agcaatgaag ttaaaagtag 88740aaggttacaa tgcccaaaca atagagtatt atagtaaaca
aatgtctata aaacattttg 88800tgttcatgat agcaaaagag attatggcag gttcaacata
acattggaat aactggcctt 88860ttcagtacaa acttatctgg aattatgaag acaaagcata
taaatgatac acttaatttt 88920taatggaact gacagaaatg attatgttga tatgatacta
gatatatttt ttggctaaat 88980ttaggtgttc acagaaacta ctaaaagtat aaatcgtacc
ccatgcttta atactataca 89040ggcatgcctc attttattgc accttgcttt attgtgcttc
ttagatattg tattttttac 89100atattgaagg tttacggcaa cccagtgtct agcaactctg
tcagcaacat tttcccaaca 89160gcatgtgctc atttcatgtc tctgtgtcat attttggtaa
ttctagcaac atttcaaact 89220ttaaaaaaat catatggtga tctgtgatca gtaatcttta
atgctagtat tgtaattatt 89280ctggggtgtc ccaaacagag agaatataag aaggcaaact
tcatagatga atgcagtgtg 89340tgctctgact gctccatcaa tgagccattc ctctgtctct
ctccctctcc tggggcctcc 89400ctattccctg agacaacaat attaaaatta ggccatttaa
taatcacaca atggtcttta 89460aatgttcaag tgaaaggaag attcacccgt ctctcacttt
aaatggaaag ctagaaatga 89520agcagcaaac gctgatgtgg aagctgcagc agttatccag
aagatctagc aaagaccatt 89580gatgaagatg gcttagagag gaaggcatgc tgaaagccaa
gacaagctga aagctaggcc 89640tcttgcacta aaaaggcaag ttatgaatcc aaaggaaaag
tccttgaagg aaactgaaag 89700tgctactcct gtgagcacat aaattacaag aaagtgaaac
agtcttattg atgatacaga 89760gaaagttcta gatagaagat caaaccagtc acaacattcc
cttgagccaa agcccaatct 89820agagcaagat cttaatgctc ttaaattcta tgaaggctga
gagaggtgag gaagctgcag 89880aagaaaagtt ggaagctagc agaggttggt tcatgaggtt
taagaaaaga agccatgtgc 89940acagcataag tgcaaggtga agcagcaaat gctgatgtgg
aagctacagc aagttatcca 90000gaagatctag caaggaccat tgatgaagat ggtgacacta
acaaacagat tttcaaatgt 90060aaacaaaaca gccttctgtt ggaagaatat gccatctagg
acttccacag ctagagagga 90120gaagtcagtg cttgccttca aagcttcgaa ggacaggctg
accctcttgc taagggccaa 90180tgccattggt gatttgaaat tcaaaccagc gctcatttac
cattccaaaa atcccagggc 90240tctgcgaatt atgctaagtc tactctgcct gtgctctata
catggaacaa gaaagcctag 90300atgacagcac atctgtttat agcatggttt attgactatt
ttaagcccat tgttgagacc 90360tgctcagaaa aaaagattgc tttcaaagta ttactgatca
ttgacaatgc acctggtcac 90420ccaagagctc tgatggagat gtacaaggat attcatgtta
ttttcaggcc tggtgacaca 90480acatccattc tgtagcccat ggatcaagga gttatttcaa
ctttcaagtc ttattatcta 90540agaaatacat tttgtaaggc taagctgcca tagatagtga
ttcctctggt ggatctgggt 90600aaagtaagta gaaaaactta tggaaaggat tcaccattct
agatgccagg aatagcattc 90660atggttcatg gaaggagatc aaaatggcag cattaatagg
aatttggaaa aagttcattc 90720taaccctcct ggatgacttt gagggatatg gtactttaat
gaaggaagtc actgcagaga 90780tggtggaaac agagaactaa gaagtggagc ttgaagatgt
gactcaattg ctacaatctc 90840acgataagcc ctgaaagaag gaggagttgc ttcttatgga
taagcagaga aagtggtttc 90900ttaagatgga atctactcct agtgatgatg ctgtgaacat
tgtgaaatga caacaaaggg 90960tttggaattt tacataaact tgattgatca agcagttgca
gggtttgaga ggactgaccc 91020tgtaaagttc tactgtgggt agaaggctat caaacagcat
tgcatgctac agagaaatct 91080ttcatgaaag gaagagtctg cagtgaattt cattgttgtc
ttattttaag aaactgccac 91140agctacctga actttaagca gccaccacca tgatcagtca
gcagcgatta acatcaagca 91200aaaagattac aactttctga aggctcagat tatcattagc
accttttttg gcaataaagt 91260atttttaaaa agatatattc tttgtttttt ttaagatata
acgctgttgc acactaaata 91320gactccatta tagtgtatat acaagtttta tatgcattgg
gataccaaga aattcatgac 91380ttgctttatt atggtagtct aaaaccaaac tggtaatatc
ttcgaggtat gcctttattt 91440tagtgcctca caaagtttac attcaagaaa attgtttata
taattcccta ttttccacta 91500gtaatgcaga ttaaatacac atctacactt gtatgacatt
ttttcatatc tttgaaaatt 91560gataatcttc tcaaaagcag tggtttggaa cctgttatat
ggaggtatct gagaggctcc 91620tgtggaccat gaaggaatcc aggattgttt ttggaagcca
acacttgttt ttctggcaaa 91680atatgtttta tatatttttt taaaaaagtt ttaaagataa
agcagcgcaa aacatttctg 91740tattttttgc agaattaaaa gattaaatgg agctagaact
caaattctcc tttatgtcta 91800tagtactata gacaattgtt agtaattttt gtgtgtagaa
gaacttcagg aaggtttgaa 91860tgtctaaaaa gttatgtgga agagaaattg agaaattttc
atttattttt aaaaaccagc 91920cataattcag tactaatata taaaggtgtg ctggtatatt
atatattata catttatgtt 91980atatataata atatataatt gtttagactc ctactcttgc
tgttgtaagt aaactaaaaa 92040ccaaaaatat aatgctgtgt atccattaag ttttctttaa
agttgtgagt tttgccaatt 92100taatttcttt acctataatg gtcacatgta agtataaaga
tttaaattac atatatttaa 92160ttatatttat acttaagcct tattattatt acttatattt
taatgcagat attctggttc 92220aggagtttgt aaaatttgga tcactagata catatctgaa
aaagaataaa aattgtataa 92280atatattatg gaaacttgaa gttgctaaac agttggcatg
ggccatgcat tttctagtaa 92340gtagtacaac ctttttatca aaagatacta ttttatttta
taaaacaata tacaaattat 92400ctttacctgg aaacaaaaaa taaatctgta attggatgcc
aattcatgta aaatagtctg 92460tgttaggtga taaaaagaga ttactttagg catatgttta
tgtatgtaaa atcacttttg 92520aaaaaaaagt tttgtcatcc catcaatatc ttagaactac
taatagacaa tctgtatgtt 92580gtgtcttttg gatttagaaa attcaaccaa aaattatgca
gaagtatgtg cttctgtatt 92640tttgggccat tgtacattat ggtccatgag aaagcggtgt
tgacagagaa gaataccagg 92700gggactgcca gtcatcagac ccctcagggt gcacctatgt
cctgctgcag aactgaagta 92760gtatttctta atgtcagctc ccatccagaa acacaaacca
tgtcagcctt agaactcatg 92820tgaaatggca ttggtagttt taatttattc atttcatcac
aagcatagat tattgtgtta 92880tttaaaatgt aaaacaggaa gcataggagt cataaatttc
cttttttctc aatgcatgcc 92940tccaaattat tatactatca tgtatttttc ttctttaaat
ctgttttggg ggcttgaaca 93000tactaaatgc tccagtactt gtggactgat atttgaatat
atgtgcgttt aactctaata 93060ggaagaaaac acccttattc atgggaatgt atgtgccaaa
aatattctgc ttatcagaga 93120agaagacagg aagacaggaa atcctccttt catcaaactt
agtgatcctg gcattagtat 93180tacagttttg ccaaaggaca gtaagttcta gaaggattat
atataatgtt actaagcttt 93240acttgggcag tggtgtaaag ggcatgttgt taattttcct
tgaattccat ttaatttgta 93300tgttcctgat taataataaa attatcactt ttagcaattt
aaattgttag ttaaatctta 93360gtctctattt ttctttctta taagcatata accatggact
gtgaggtgat tttttaaaaa 93420cagttttaat ctctaattat gtatgaagga taggatttta
tccattttta gtatgaagtt 93480ttgtaatatt ccttgagcca caagtaaatt ttctaaatat
tcttttcttc tcgtcactaa 93540ataaaaattt agcctgagat tttaggattt ttttctatcc
tctgtgaaga aattagttta 93600attatccagc taattctgac tttttaaaac cttaaaaaaa
ctttgatttg tgtttgttca 93660tctttactac ttaacacagt gggttaaaaa tacaaatttc
agtcagatag ttgagagggg 93720ttttttgggt ctagataatt ataactgaat tttgttatct
tagataattt ctctaattgg 93780atgttctaaa tttagattct aaattgatca atttttgtgc
actgatgtgt cctatttaag 93840ctaatagtac ttaaacttaa tgacttatct gacagtgaag
acagtgataa ctgggcagta 93900gtacaggagt agggagtatg gcagaaaatt cttacagggt
cttacatctg gtatcctgga 93960aaattttatc ctttggaatc ggaagtgaag atggaaaaaa
atgtattcat atggtgaagg 94020tatttgtcaa tcaatctatt tgtctgtctg tctatgtcag
aataccagaa agtagggtta 94080tattgcttct tcctttcttg aatacagtcc ttctggtgga
atcaaagacc acagaaactt 94140tacttgagaa attccgtgat ttgagcagag cccacctata
tcaattccat atatctagaa 94200tattttggtg caatttagcc ttccatctgc cataaatgct
tgttggtcct tgggtttttt 94260tttttatctg caagtgggaa ttgccatggc tattaaatca
ttagaacatc tctgaatgat 94320gtaacattac ctttactact tacgcattat gaagaaatac
caaaaagtat catggggcaa 94380ttttaggata aactatataa aaaaaaaaga tttggccagg
tgcagtggct catgcctgta 94440attccaatgc tttgggaggc tgattgcttc ctaaagcgct
tgggtggatc acttaagccc 94500aagaggtcaa agcatagtga gctgcaatcg tgccattgca
ctctagcctg agtgacacag 94560tgacaccctg tctcaaaaaa aaaatttttt ttttttgaag
gtaaaactaa tggaaagagg 94620ttgagaaaat ggtatgccag ttgagacact atggtttaat
ggaaagatta gttgattcag 94680aactcactgt acaggattct aattctgtct ctgctgctaa
caaattgtgt ggctttgggc 94740agattactca atcatatgtc tccatgttgt cattgttaaa
gatgaaatat tgaattagat 94800gatcttgaag gtcccttctg gttcttaagc ttatgcagtc
atgtgcatgt gcacatccaa 94860cccctccaaa ataaagaaaa taggcctgat tattcaaatg
atttgaactt taaagctatt 94920tacatataaa agattggttt acttgtgaat tatttaaccc
tactctgttc gtatcattta 94980aaagttcttc aggagagaat accatgggta ccacctgaat
gcattgaaaa tcctaaaaat 95040ttaaatttgg caacagacaa atggagtttt ggtaccactt
tgtgggaaat ctgcagtgga 95100ggagataaac ctctaagtgc tctggattct caaagagtaa
gtttatatag actaagttag 95160aattactcta tctctgaact ttcatatttc tttcacatga
tttgtatttt ttagcccatc 95220taattttaaa aagaaggttg gtgtggcatt acacaattta
ttctcagttt gtggttcttt 95280aattatagaa gctacaattt tatgaagata ggcatcagct
tcctgcacca aagtgggcag 95340aattagcaaa ccttataaat aattgtatgg attatgaacc
agatttcagg ccttctttca 95400gagccatcat acgagatctt aacagtttgt ttactccagg
tatgtatttg aatgatctta 95460ttgattttcc agctttctat ctttattgta tttaatgaat
cattactaat ttttaattcc 95520tttaaaacat tttcttgatg tcatttgggc cctcttaatt
tcttatgttc atatggcttt 95580tcatgcttta tacatattct aatctccttg actgagaatt
attttcattt ttataaaaag 95640accttttctt tttttttttt tttttttttg agatggagtc
ttactctgtc gcccaggctg 95700gagtgcagtg gcgcgatctc ggctcactgc aagctccacc
tccaaggttc acgccattct 95760cctgcctcag cctcctgagt agctgggact acaggcgccc
gccaccacac ccggctaatt 95820ttttgtattt ttagtagaga cggggtttca ccgtgttagc
caggatggtc tcgatctcct 95880gatcttgtga tccgcccgcc tcggcctccc aaagtgctgg
gattacaggc ttgagccacc 95940gctcccagcc aaaaagacct tttctttcag taacctaatt
ttagttttcc atttagtgag 96000ttgtaaatta tagtattttt tttttgctta aattgacttt
taaaaaacaa ttctctttaa 96060catttctcat attttataat tgattgattc tctaaacatg
agctgtattt gttttgcttt 96120gttctctcct ttttcaaaat actgagctga aatgcatgtg
tttgacctat aggtgctttc 96180taccccagta ctactcacct ttctcacaat aagtatcagt
atattacctt actttatgaa 96240tactaaaact tcttattttg gaaaacaaaa ttttatcctt
tgcaaagtct ctcttgaagg 96300cctgtcagat tatgggtaat gattaaaggc tcccattaat
ataattgaaa ctatttgagt 96360ttccctgtat catttagtat ttttaactca cgattatttt
ggtcaacttg aatgtatatc 96420agtttagtcc agagaatgtt atttgctaat ttaaggtgat
aatattcttt atttctccag 96480attatgaact attaacagaa aatgacatgt taccaaatat
gaggataggt gccctggggt 96540tttctggtgc ctttgaagac cgggatccta cacagtttga
agagagacat ttgaaatttc 96600tacagcaact tggcaaggta aattgtcaga attttttcaa
atagagtata atcatttcat 96660ttaggaaaaa cttaagagcg tttctaaagt tcactttcta
caacatttta aggagtgctt 96720gtagaaaaaa aaggtttggt tgtcagatgt tggagaaatg
ctgtgttaaa taaacagcta 96780tctttactga atgaaggggg ccagcccctc cacacctgtg
ggtaattctc gtcaggtggg 96840accagagact gagaaaagaa agaagacaca gagacaaaag
tatagagaaa gaaaagtggg 96900cccaggggac cagtgctcag catatggagg acccgcacca
acactggtct ctgagtttcc 96960tcagtattta ttactgtttt cactatctca gcaagaggaa
tgcggcagga gagcagggtg 97020atagtgggga gaaggtcagc aagaaaacat gtgaggaaag
gaatctgtgt cacaaataag 97080ttcaagggaa ggtactatgc ctggatgtgc acataggcca
gatttatgct tctctccacc 97140caaacatctc agtggagtaa agaataataa agcagcattg
ctgccaacat gtctcgcctc 97200ccgccacagg gcagtttttc tcctatctca gaaatgaaca
aatgtataat tgggttttat 97260accgaggcat tcagttccca ggggcaggca ggagacagtg
gccttcctct tttactaatc 97320ctccccagca cagacccttc acggatgttg ggctggggga
cggtcaggtc tttcccatcc 97380cacgaggcca tatttcagac tatcacatgg ggagaaacct
tggacattac ccggctttcc 97440agggcagagg tccctgcggc tttccgcagt gcattgtgtc
cctggtttat tgagactgga 97500gaatggcgat gacttttacc aagcatactg cctgtacaca
ttttgttaac aaggcacatc 97560ctacacagcc ctagccttaa accttgattc catacaacac
atatttttgt gagcttcagg 97620ttggggcaaa gttacagatt aacagcatct cagggcaaag
caattgttca gggtacagat 97680caaaatggaa tttcttatgt cttccttttc tacatagaca
cagtaacaca ctgatctctc 97740tttcttttcc ctataactga agaacttttc agaggcttta
acatgtaatg tgcatgaaca 97800tcttcaagag gaagatgaat taggcagtat tattcaaatt
gacttgacca agagactgtt 97860ccttggtagc aggagttcat tgttaagtga ttcagtgaaa
tacagaaagg aatacataag 97920cttttctgcc tgcctttctg cctttagtta tctcagggag
aattaatctt attgcttagg 97980gtctaggatt ttgactgtgc catattcact agcagagact
ctgtctatta aaacgtcaca 98040cagtcatgta taacctacat attataagta agaccaggga
atgctcagtt cttagtaggt 98100ccaaccatag tggtaagctc tttctcgcat aagcttgcta
ggataaggtt ctcactagta 98160agtaccatgt tagtgttgtc tgttattatc agctattcct
aaattcatat tttcctgaaa 98220tatctccaga tgtcattgat tttcctcttt tctgggaact
tatagcattt attgtttctt 98280ttatacaact taatcacagt cttctgttgt ttattagatc
ttggtttttg tttgcttgcc 98340ctttttttcc ttgacttaaa aaaagttcct ttagatccca
atagattact aggcacacaa 98400ttttgtcata tattgtcaaa acaatggaat atatactggt
atttaagaag tagacataac 98460aaagaataca tcaaaagatc actaatttag attaacaaaa
gggaaacagc agactaaatt 98520ataaagttat cttttcaagt aatttttcta gttatgaaag
tgatatactg cttatagaga 98580aattggaaaa tattacaatg aagatacgtt ccatttgttg
tagtctctgc acaactacac 98640aatttctttc aatagtgaaa ccattctata tatacaattc
tatatcttgc tatttttcat 98700atatcaagat tttcccatta ttaatattct tttgagacat
aattttaagt gaatatacca 98760taatttattt acaacattcc cctttattgt aattttgagt
taatgttctt ttgcttttta 98820acatttttag tgttttccat agttccgtga gcttaaaatt
cttttaaaca taagtaaatt 98880gaagagactc taaggaaggc gttttcaaaa tacatgtaca
atgaaatata tttcttagta 98940atttagtttg taggaaatga aaggtaaatg gtgtaatcat
tagtcagtca tagatatttt 99000aatgtggata tttcctatct gtatttaaca ccataatttt
actttcatct ttgtttgttt 99060gaagtaattg atgtgttcag tggtttgtct agatatttgt
actgccttac tgaaacaatc 99120aaaatgccat tcctacaaaa atgattgcat gtcacctttc
cattttataa aaattagcta 99180ctgtatccct ttgttatcct tttcaattag tggtatggtg
aaaatattcc aaagagggat 99240atatatttaa aattattttc atatgtttta agccaagaga
aataatggta tattttttta 99300ttttttaaaa aatattttca tactgttgta aaaggagcca
agaaactatt gtgaaatctt 99360ttcttttgct atttgaaatc tagagtgttt tttgctttct
tcctttatcc tcatgcccac 99420atatacttat attctttttt aaattaattt taacatggat
tatttgtgta atagccttac 99480atgtggatat taacagtgta aacagtacca catataacca
tcaagacacc tcaattagaa 99540tttataggac tagaatgaca gattcagatg gtttaattac
atttaaaaag ttttctgaaa 99600aaacttttgc aataaaacaa attgcccatc aataagtttg
atatctttta aaatgatttt 99660tggttatctg cacatgaagc aaacaaagtg tattccacaa
aattcttagg cacagtctga 99720gatagctgcc agaaagaaca gaaagagttg tcatttatgt
cttgtgagta caatttctga 99780aagttgaatg agggcgtctc tttctgggga tgagaagttt
actgctctct cttattgctt 99840catggcagta ctgctgggca aggtaggttg tttgttttac
accatcactc tgtaatacat 99900actgtggagc tctgtctaca tctcccggca aactgaacca
tctcatgatc atagcattca 99960tttctgggaa ctgctgacag gcaaatagga caggaccagt
ggctaacctg agattcacat 100020cagctgatgt tggtttgcct atgttagaac atgaggtgaa
gtcgaataca tcatctatta 100080gctgaaaagc tattcctaca ttttttccgt actgataggt
gatctcatgc accactgggt 100140cggggcatcc tagaacagag actgctttac aactgttggc
tatcaggctc gcagtattct 100200tgaaggtctt ttcaaggtat tgtgcaaatc tctcatgctc
attttctttt gacccgagct 100260gaagaaattc accacacacc aaatcttcaa taactcgggt
taaaatagat ataacagctg 100320tatttccagt ttgtgcccca cctatagata ctacagaaag
aattaaatct ccagcaagga 100380cagccttctt ttcaccccag atcttgtgtg ttttcctttt
cgagaacgtg cattatcaat 100440aacgtcatcg tgaacaagac tagcagtgtg gatcatttct
gcaattaagg ctgtggcgcg 100500ctggctagct tgcacatgtc gggagttatt atgatgaata
ttacatgctc gggccattag 100560taccacaata attgatcgaa aggcttttcc ttttacatca
aagtagtact cagagatttc 100620cttaagttct gttgttgata tgagcggttc ctttctaata
ccctcataca gacctttcaa 100680gtctctccaa ccgagtttga aaggatcggt gtatttctca
ccactgtgtg ttttgctgta 100740cggggttgtg tgatgaaact gtgatatact atatacattt
ggacaggcag gtgttaaatg 100800cttcacaaga ttaaaatagg gtatctgaga caagtcaagt
cccttctgcc tatgagcctg 100860cgcgggcatc ggcagcggcg cgcggccccg gcggccccgc
aaggctcggg gagcggtctc 100920cacgccgccg gtctccagca acagccgcgc cgcccccgcc
accagcgcga ggccacggtc 100980ggagtctgaa agtcgcggta ggatggtggc tccgcctctg
gcccgcgatc ctcctgccag 101040gacctggagc ctgaaacctc ttatattctt tatatccttt
accttctcgc ttcactccta 101100gcggttttga aatcctcttt attccttttt cctccatggt
gcagatatgg gattcagaga 101160tcaggatctt agtgcgacta ctttgaaatt atcagcatca
ttctcaatct tctctgaata 101220tgattcttat tttcctctct tcccatcatt agctaacatc
ttggtccaca ttccttgaat 101280acttttagta ctcattgttt tctcatcacc ttacctcctg
ccattatttt ggatgccctt 101340ccaatactta aaaaaaaaat tccttggctt ctctacccca
aagttatgat tatgttaaat 101400gagttccttt gaactctata atcccatgta ataaccttac
ttagaaaatt tcctaccctg 101460aaatctccct gtctgactat aactttatag cctttggctt
ttttcaacat aaatgccttc 101520tttttgatat ctttggtatt gctagtgtct ttcacacttt
cttcttattg gaacgtaaat 101580tggtgaccct ttctagagag cttctcatag agcagtttgt
atcaagcgcg tttaaatgtt 101640catatctttt aaactacttt cgctggtatc cacaattata
tcaccccccc ttcccttgat 101700tatctgcttc actttcccta ttatttccta gtacgggaac
aatacaactt agcattttta 101760aattgtgctt ccatccctca aacactaaaa gaaaaaaatc
agatataaat ctttattgtt 101820ttcattgaaa attggtttcc aacattggtt aggcacttat
gactcttact ggttgtatta 101880gtctgttctc acgctgcaaa taaagacata cccgagactg
ggtaatttat aaaggaaaga 101940ggtttaattg actgacagtt acccatggct ggggaggcct
caggaaactt acagtcatgg 102000cagaaggcac ctcttcacag ggcagcagga gagagaatga
gtgccagcag gagaaatgcc 102060agatgcttac aaaaccatca gatctcatga gaactatcac
gagaacagca tggaggaaac 102120cacccgcatg attcagttgc ctcccaccag gtccttccaa
tgacatgtgg ggattatggg 102180gtttacaatt caagatgaga tttgggtgag gacaatgcca
aaccatatca ctcccttact 102240tgatttcttt cctggtccta tctcaaaccc ttctggtttt
ctatcttaaa tctttctttt 102300cgctgtattt ttcttcatct ccttcttcca taagaaaaat
agaggcattc cgaattaaaa 102360gtgagactga tttttgccta tcaaagtgac aaggatttag
aaaaagtata atgatcattg 102420ttggcaggga tgtgataaaa tatacatttt cccactgctt
attggaacat caaatggtaa 102480ccactgccag acagcttcta atgcagtgtg tatcaagtcc
ctttgaaatg ttcttatctt 102540ttgaacagct aattaagtat ccttaataga gatgtacaca
aatatttatt tataagaata 102600ttattgcaat gacatgactg tatttaaaaa tttttcttag
tgtacattta tgtttccaat 102660gttaaaatta gtgcattcgt gtgacaatat acaataatta
aaaattatta atttcaagga 102720atatatagtg gcactagaaa ataaatttta tgaacacatt
gttaagtaga ggggaagaag 102780ataaaactta tttcctactt ttgttttcta aaatgtgttt
tggaataatt tctcacaaca 102840gcctcatgag atagacattt tattattctc cactttaagg
atgaaaaacc tcattttagg 102900gagttctgaa ttgtccgcgg tcacagagag agcaagttgt
ggatcaatat tctagttcca 102960atctgacttg agagtcctgg gtcttgagag tcctgggtct
atccacctta ttgtgtggcc 103020ttctaaactg tgtaattaag agatttaact ttgagcctac
atggtctagg ttttttaaaa 103080aactgacttc aagtatataa ctgaaaatat agtcacttag
aatcttgtaa ctcaagaact 103140acattgtttt atcctgtaag aatgcaataa tatccaaaat
acactaattt gattaatatc 103200aaaaacctat actttattta aatgttatag caacttacca
attctatgta cttaatgagt 103260tttaggtaaa aagagtggat ttctttaaag acatcttcaa
aaaaaaaaat gtagagtcat 103320cccataggct aaaagtttct tacttcttaa tttgctttgg
ctgctataac aaaataccat 103380agactgggta gcttaaacat cagacattta tttctttgaa
ttccagggcc tggaaagtct 103440gagatcaaag ttctggcagg gattggtttc tagtgaggtt
tcttcttggc ttgcagatgg 103500ccatcttctt gctgtgtcct cacatgggag agagagattg
ctctaatgtc tcttcctctt 103560ataagggcac tagccttgtc acattagagt tccaccctta
taacctaatt taacttttat 103620cacctcctca caaggcccta tctccaaata cagtcatatt
gggggttaag gcttcattat 103680ataaattttg ggtaaggggt cactgacatt tagcccataa
cagacacatt ccatccagat 103740cactgacagt gatagcaaaa ggtattttgt aaaaaaggaa
aattcttcct ggaagttagt 103800gacaaaagtt taggaatcct cagcatgtcc cttggcttat
cttgacaatt aatgctcatc 103860atttatttaa atgctttttt gaagtaattt atatttcagc
ctataattcc ttttgaagaa 103920attaaattta cagatttact acccacctgt tgagatagta
tttccttttc ttgttctaag 103980agttccttaa tataagctta aagatagtct gctgctgggc
atggtggctc atgcctgtaa 104040tcccagcact ttgggaggcc gagttgggtg gatcaccagg
tcaggagatc aagacaatcc 104100tggctaacac agcgaaaccc tgtctctact aaatatacaa
aaaattagct gggcgtattg 104160gcgggcgcct gtattcccag ctactgggga ggctgaggca
ggagaatggt gtgaacccag 104220ggggcggagc ttgcagtgag ccgagatcgt gccactgcac
tccaacctgg gtgacagagc 104280gagacttcgt ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa
agacagtctg ctaattccag 104340ctactagaat tttctatata attataaaat ttatttgtaa
tttgccttga aaacttggta 104400tttccatcct aatgtgatgt gtcatttagg gtaattttgg
gagtgtggag atgtgccggt 104460atgaccctct acaggacaac actggggagg tggtcgctgt
aaaaaagctt cagcatagta 104520ctgaagagca cctaagagac tttgaaaggg aaattgaaat
cctgaaatcc ctacagcatg 104580acaacattgt aaagtacaag ggagtgtgct acagtgctgg
taagctgccc attgaaacct 104640attttaaatt caaggtatgt gtttggcatc ctgtgtaata
taaatgtaca atgtcttaac 104700gatctggact tatgccaatg cccagaggga gaggcattct
ataatgacta gagattgtgt 104760ttggtgatca tagactataa ctataggaag tatttggcta
gttggttaaa cattcttttc 104820acctcttgct taagcttacc aagaaagtat catttttaaa
ggaattgttt ttgtttacat 104880tttctataaa aatatttttg aattcaatgt tttttgttcg
atatcaatga ggagaaagga 104940agttttctca tcagtttatt ttggtttgcc tgaagagtta
tagaaaactg aaacgcaaat 105000agtttcaaag cttttattca ttcaaaagtt tttgattcaa
aaagactatg ttcttaacaa 105060ctatatcacc tttaatgtat aataaagttt tgtcatctta
gatttcatat atgtttaagt 105120catttatgta tgatagtttt ctaatattta atcagtataa
tatggcagag taaaacatta 105180tttccacctt tatgttaaaa ggtcggcgta atctaaaatt
aattatggaa tatttaccat 105240atggaagttt acgagactat cttcaaaaac ataaagaacg
gatagatcac ataaaacttc 105300tgcagtacac atctcagata tgcaaggtaa ctaatatcct
gattatttgc tgtagatgaa 105360gcaaccgtgt tgaagtagac attaggaaat catctagacg
ttttcataga taataaaggg 105420aatatatagg gttaagacca tttaaattgt ttatatttat
aaaactagct gaaagaaaaa 105480tgttttatcc atagggtatg gagtatcttg gtacaaaaag
gtatatccac agggatctgg 105540caacgagaaa tatattggtg gagaacgaga acagagttaa
aattggagat tttgggttaa 105600ccaaagtctt gccacaagac aaagaatact ataaagtaaa
agaacctggt gaaagtccca 105660tattctggtg agtatatttc agtatgataa atgaaatttt
agagcacaga cttcaaactt 105720tattgttgtt atttaatagt ttgccatttc tatatttaca
gtaacagtga acatttaagt 105780cttttaagtc ttacatttaa cttttttttt ttaggtctta
tagtcatggt tatagtccac 105840gtgggaaaat ggcatatgct ttatttctat taagtgttgt
cttatttata gggattgtag 105900gtttttcttc aaaactgtct cctatttatt gaggcttagg
ggtaattatt agtggtgctg 105960tgggttgtgg tattgtgttg aattttggtg gggctttcat
ggggttaata gtctttttta 106020tttacttggg tggtataatg gttatttttg gttatactcc
agtgatagct attgaggagt 106080atcctgaaac atgagggcca agtactgata tttgaggggc
cttattatta ggattattaa 106140tagagttgat actggtttgg tgaatagttg aatatgatgg
ggtggtgatc acggttgatt 106200ttaatagcat agggagttga tttaattttt gagggggagg
ggttgattca tgaggatttt 106260gtaggtgcag ctgccttgta taattatggg tgttggttgg
tggttgctgg ttgatcattg 106320ttagtatttt tgtcgcaatt gaaattactc agggtaatag
attagataat taatagtaga 106380gtttaggcct ttttggtcag atacagtaat ggaggctgaa
gtttgggttc gtgaaatggt 106440ttttggtata gacttttcta gtcaaactgg gtctagtaga
agtgaagcta gattttggct 106500tatgaatagg cttaagtcgg ggggctgaat ggtgaattgt
agctgaataa aaacctagta 106560tactggagaa gttaaatgtc tataatgggt actttaaggt
tgttagttat gaaattaagc 106620tctattgcta gtaagagacc tagggtggtt acacctaggg
ctgtgagctt taggtggagt 106680ggtatagttg tttgggggga tgaagtaggg ataatactgt
tagtgatgag gaatccggcg 106740aagatactgc cgattgctag gtgctgaact gagttaattc
ggagaggatt atcattaata 106800acaatcagaa ttgtaaaaca aggttgtcct attacagcac
ctaaggttat aaagtaagca 106860caagtaaata cataaaaacg ttaggtcaac gtgtagctca
tgaggtggca agaaatgggc 106920cacattttct accccagaaa atctcacgac aacctttatg
aaatctaagg gctcaaggag 106980gatttagcag taaaccaaga gtagagtgct tggttgaggt
tgaataaggc cacgaagcac 107040gcacacactg cctgtcaccc tccgcaaata tcattctaga
aatattattt aaattctcta 107100tacatgaata gaggagataa gtcgtaatat ggtaagtgta
ctggaaagtg ctcttggaca 107160aacaaagtgt cgcttaaccc aaagcatcca gcttacaccc
ggaagatttc atcacaacct 107220ggtcactttg agccaaccct agccccaaac ctcactaaaa
atactattaa accatcgtaa 107280tcaaaccatt taccttagac aaaagaatag gcaatagaaa
ttcttatctt ggcacaatag 107340atacagtacc gtaagggaaa gatgaaagaa ctgagcaaag
acaagccctt ataccttctg 107400cataaagtat taagtagaaa taactttaca cagagatagc
caagtccccc gaaaccaaat 107460gagctatgca agaatggctg aaagagcgta ctcacctacg
tggcaaaata gtgggaagat 107520tcatgagtag tggtgataag cctatcaagc ctgctgatag
ctggttgtcc aagatagaat 107580cttagttcag ctttaaactt acccacagaa ttacttaatg
tccctgtaag tttaactgtt 107640aatctaaaga gggacagctc tttagaccct aggaaccaac
cttcctacag agagtacaaa 107700ataacatcgc catagttggc ccaaaagcag ccaacaatta
agaaagtgtt caagctcaac 107760atccaagtat cttaaattct aatcactcta cggaactcct
aacattacac tggtctaatc 107820tattatttaa tagaagcaat aatgttaata taaataacat
gaaaatattc tccaccgcat 107880aagcttacat aagactggaa taacccactg actgacagtt
aacagctaga tattttacaa 107940taagcatcct attatttata ctgttaatcc aacacaggca
tgctctaagg aaatattaca 108000aaaagtaaaa ggaactcggc aaatcttacc ccacctgttt
accaaaaaca tcacctctag 108060cattaccagt attagaggca ctgcctgccc agtgacatat
gttcaacgac caccatatcc 108120tgaccttgca aaggtaacat aatcacttgt tccctaaata
gggacttaga agaatggcca 108180catgagggtt cagctgtcat gagggttcag ctgtctctta
cgtttaatca gtagaatctg 108240acctattggt gaagaggagc ttataagcaa ataagatgag
aagaccccat ggcactttaa 108300ttcattaatg caaataaaaa ctcaaaaagc ctataggcct
taacctacta tctctgcatt 108360aaaaattttg gttggggtga cctcatagca tattcaacct
ccgaacaacc taaactaaga 108420ccacagtagt ctaagcgagt taatacacat tgacccaata
atttgatcaa cagaacaagt 108480taccctaggg ataacagtgc aatcctattc tatcatatca
ataatagggt ttacgacctc 108540gatgttggat caggacatcc taatggtgta gccgctatta
agggttcatt tattcaatga 108600ttaaagtcct atgtgatctg atttcagacc agagtaatcc
aggttggttt ctatctgttt 108660aacatttctc ctagtatgaa aggacaagag aaatacggcc
cacttcataa agtgccctcc 108720ccccataaat gatgctatct caatctagga aatcaccaca
cacccaagaa cagggtttct 108780taagatggcg gagcctggca atagcataaa acgtaaaact
ttacaatcaa aggttcaact 108840ccccttctta acaatatgcc tataattaac cttttcctac
ttatattccc actctaattg 108900ctatagcatt ccttacactt aacagttacg caaaggacct
gataccgtag gcccctgtgg 108960actgcttcaa ccatttgctg acccaataaa acttttcacc
agagaaccct tacgaccctc 109020aacgtctact gttacccttt atatcattgc ctccaaccct
ggccctttct atcaccctcc 109080tcttctggac tccccttcct ataccccatc ccctaattaa
ttttaatata ggcctcttat 109140ttattctagc cacatcaagc ctagcagtct attccattct
atgatcagga taagcatcca 109200attcaaatta tgtactgatc ggcacactac gagctgtggc
ccagacaatt tcatatgaag 109260tcaccctagc cattatcctg ctatcactac tactgctaag
tggctcaact tatatgcatg 109320catcacaatg ccagaattac tctgaccgct cctaccatca
tgacccttag ccatattatg 109380atttatttcc acactagcaa aaactaaccg agcccctttt
gacttaacag aaagagaatc 109440agaactagtt tcaggcttca atgtcgaata tgctgcaagt
tcatttgccc tcttctttat 109500agcagaatat atgaatatta ttgtataaat gccctgacta
ctactatttt tctaggagta 109560ctacacacta tgtattcacc agaactctgt accataaatt
tcattaccaa gaccctcctt 109620ttaaccaccg tttttatgaa tccgaacagc atacctccaa
ttccactaca accaactcat 109680atacctttta tgaaaaaatt tcctaccact tacattagca
ttctgcatat atctcaatgc 109740ctttcctaat ttccagcatt ccaccccaaa cataggaaat
atgtctgaca aaagaattac 109800tttgatagag taaacaagag aggttaaaat cctcttattt
ctggaactat aggaattgaa 109860cctatccctg agactccaaa attctccatg ctacctatta
aaccatatcc taaagtaagt 109920tcagctaaat aagctattgg gcccattctc ctgaaaatgt
tggttatacc cttcccatac 109980taattaatcc attagctcaa cttattatct ctcttactat
tttcacagga accctcatca 110040caatgctacg ctcacactga tttcttatct gaacaggcct
aggaataaat atagtagttc 110100ttacccccat cttgattaaa aaaacaaatc tccactctac
agaagcagcc accaaatatt 110160ttcttacaca agcaactgca tctataattc tcatgatggg
tatccttttc aacaacccgt 110220cctccgggca atggacaata ataaacacta ctaatcaatt
ttcatcctta ataataacag 110280ccctagtaat aaagctagaa atagccccct ttcacttccg
agtcccagaa gtaacccagg 110340gaacttctct aatgtctggc atacttctcc tcacatgaca
aaaactagcc cctatctcaa 110400ttatatttca aattttccca tcaataaaca cgaccagtct
cctatctatc acaatcctat 110460ccattaacgt aagcggttga ggaggactta atcaaacaca
attctgcaaa atcttaacct 110520actcctcaat tactcatata ggttgaatga tcccagtact
aacttataat ccaaacgtta 110580ccattataaa tctgattgtt taccttattt taacaactac
cacatttcta gcacttagcc 110640taagtataag cactacaacc ctgtcactgt ctcacacttg
aaacaaatta acatgattaa 110700cacctatagt ttcactaatt ctactatccc taggagcttt
acctccatta acaggatttc 110760tgcctgaatg agtcatcatt caagaatttt caaaaaacaa
tagtcttatt accccaacca 110820ttatagctat cataacacta ctcaacctgt agttttatat
atgcctaatt tactccatct 110880caatgacaat attccccaca tccaataata cgaaaataaa
atgacaattc aaaaacacaa 110940aacccatatt actcctccct ccacttattt cttctacctt
cctcttaccc atctctccac 111000tgattctagt tataacttag aaatttaggt taaataagac
cagggacctt caaaaccctt 111060agtaaatgaa ttatacttaa tttctgtaac aaacccaagg
actgcaaaac tctattctgc 111120atcagttgaa cgcaaatcaa ccactttaat taagctaagt
ccttgctaga tcggtggaat 111180tcaaacccac aaaaatttag ttaacagcta aataccctaa
tcaactggct tcaatctact 111240tctccctcca tgtgggggga gggtggtagg ccggagaagc
cctggcagca ttgaagctgc 111300tcctttgaat ttgcaattca acataaaaaa ttacctcagg
gctggtaaaa agaggtcttg 111360acctctgtct ttagatttac agtccaatgc ttactcagcc
attttaccct tttttccact 111420tatgttcatc aattgttgat tgttttcaac caatcacaaa
gctatcggaa cactatacct 111480gctgttcggc gcatgagtgg ggatagtggg tacctcctta
agccttctaa tttgagcaga 111540attaggtcaa ccaggaactc tgctaggaga tgaccagatc
tataatgtta ttgttaccgc 111600ccacgaattt gtcataatct tctttatggt catatcaatt
ataattgggg gtttcggcaa 111660ctaactagtc cctctgataa ttgctgcccc tgatatggca
tttccacgga taaataataa 111720tgagcttttt acttctcccc cactctttcc tactcctact
tgcatcctca atagaagccg 111780gtgctggaac tggctgaaca gtttatcccc ctttagctga
aaacctaaca catgcaggat 111840cctttgtggg tcttaccatc ttctcacttc acttggcagg
tattctattt taggagccat 111900taactttatt actacaatta ttaacaaaaa gcccccagcc
atatcccaat atcaaacacc 111960ccttttcgtc caaccattcc tcattacagc aatcctactc
ctttctctct cagtcctagc 112020cgctggcatt accacaatat taactgaccg taacctcaac
actacttttt gaccctgctg 112080gtgggggtga tcctatctta tatcaacatt tattctgatt
ctttggtcac cctgaagttt 112140atatccttat tctatcaggc tttgggatga tctcccatgt
cgtgacgtat tactctggaa 112200aaaaggagcc atttgggtat atgggcatag tatgagccat
aatatctatt ggcttcttag 112260ggtttattgt atgagcacac catatattta cagtaggaac
agacatagac acagacacat 112320gagcatactt cacctccgct accataatta ctgctatgcc
tactggcatc aaggtcttta 112380gctgattagc tacactgcgt ggtggtaaca tcaaatgatc
tcccgcaatg ttctgagccc 112440taggattcat ctttcttttc acagtaggag gtctaattgg
cattgtacta gctaattcat 112500cactagatat tattttacat gatacatact atgttgtagc
tcatttccac tacgtcctat 112560caccaggagc ggtgttcgcc atcataggag gctttaccac
tggttccccc attctcaggt 112620tatatgctta atcagaccta cgctaaaatt cacttcacca
ttatattcat aggtgttaat 112680ttaacctttt tcccacagca cttccttggc ctatccggta
tgccgcaacg ttattccgat 112740tatcctgatg catacaccgc atgaaatatt atctcatcct
taggctcatt tatctcatta 112800gcagcagtta tgctaacaat ttttataatc tgagaagcct
ttgtttcgaa aagaaaaact 112860ataacaattg aacaaccatc tagtaattta gagtgacttt
atggctgtcc accaccttac 112920cacacatttg aagagccaac ctacattaaa cccttaaatg
aaaaagaaag gaattaactt 112980ccagaaactg gtttcaagcc aatcaaaaac ctctgtgact
ttctcgataa gatattagca 113040aattcattac gtaactttgt caaagttaag ttataggcta
aatcctatat gtcttaatgg 113100ctcatccagt tcaattaggc cttcaagacg ctacatcccc
tatcatagaa gaaccgctca 113160ctttccgtga ccacgttctt ataattattt tcctaattag
ttcctggttc tatacattat 113220ttccgtaata ctcacaacaa aattaactca tattagcacc
acagatgccc aagaaattga 113280gactgtttga actatcttac ctgccattat cttaatttta
aggcctctca tccctacgta 113340ttctgtataa aacagatgaa gttaataatc cttcccttac
tgtcaaagca attggtcatc 113400aatgatattg aagctatgaa tatatagact atgaagaatt
aagcttcaat tccttttttt 113460tttttttgag acagagtctc gctctgtcgc ccaggctgca
gtgcagtggt gtgatctcag 113520ctcactgcaa gctctgcctc ccgggttcac gccattctcc
tgcctcagcc tcccgagtag 113580ctgggactac aggcgaccgc caccatgcct gggtaatttt
tttgtatttt tagtagagac 113640ggggtttcac catgttagcc aggatggtct tcatctcctg
acgttgtgtt ccacccactt 113700cagcctccca aagtgctggg attacaggcg tgtgagccac
tgcgcccggc ttaagcttca 113760attcttatat aaccccaaca ccagacttaa aaccaggaga
acttcgactc cttgaagttg 113820ataaccgaac aattctccca acagaaatac ccatccatat
attaatctca tctgaagaca 113880tcctgcactc atgaactatc cccttattag gcctcaaaac
agatgcaatc cccagatgct 113940taaatcaaac taccttaacc actgggcgac caggtcttta
ctatggacag tgctcagaaa 114000tttgtgaatc taaccagttt tatacctatt gtcctagaac
taatcctctt aaaatatttc 114060aaaacctgat ccacatctac actaaaatat cactgtaaag
ctattcagca tttacctttt 114120aagttaaaga ttgacggagt ctacacctct ctgcagtgaa
tgcctcaact agatacttcc 114180acatgatcca ttattatcct gtcaataatc ataactttat
tctccattat tcagttaaaa 114240ttattaaatt tcatttatat tatccctaca ccaaaaataa
tcaaaacaca aaaacacaag 114300gcttcctgag aattaaaatg aacgaaatct attcatctct
tttgctaccc ctacaattct 114360aggcctacca gcagtagtat taatcattct gtttcccact
gtttccaacc tctagtcatc 114420aaattagtaa ccgattattt tctattcaac gatgattaat
ccaacctgca ctaaaacaga 114480taataattac ccataacatt aaaggacaaa cctgatccct
tataataata tccctaatta 114540tcttcactgc ctcaaccaac ctccttgggc ttctacccca
ttcatttaca ccaactatcc 114600aattatcaat aaacctgggt atagcaatcc ccctgtgagc
aggcgcagta attacagtct 114660tctgctttaa aacgaaaaac tccttggctg gctttttacc
acaaggcaca cctatgccac 114720ttatccctat actagtaatc attgaaacca ttagcctatt
tattcaacca atagcattag 114780ctgtgcaatt aacagccaac attatagtca gtcatctact
aatacattta attgcaggag 114840acacactagt actattagct attagttttc ccacagcttc
agttgctttt attattctaa 114900tcctactgac tattctcaaa ttcgccatag accttattca
ggcttatgtc ttcacactac 114960tagtaagcct ttatctatat gacaacacat aatgacccac
caaacacatg cttgccatat 115020agtcaaaccc agcccctgac cactaacaga agctctctca
gctctactaa taacatctgg 115080cctggccatg tgatttcact ttaattctac tactctttta
accctaggcc tattaatcaa 115140cacactaact gtataccaat gatgatgtga tattatctga
gaaagtaaat ttcaaggcca 115200ccatacaaca gttgtccaaa aaggcctcca atatggaata
attctattta ttatctgaga 115260agtattcttc tttgctggtt tcttctgggc attctatcac
tctagtctag ccccaatgcc 115320agaattagga ggacactgac cccccaacag gcatttttcc
cctcaaacgc ttagaagtac 115380ctttctgaat acatctgtat tatttgcatc aggagtttca
gttacttcgg ctcatcacag 115440cctgatagaa ggaaatcgaa agcaaataat tctagcacta
tccatcacga ttaccttagg 115500tatttacttc accctcctac aaatctcagt actttgaggc
cccttttact atctctgatg 115560ggatctatgg ctcaacattc tttacagcca caggctttca
tggatttcat gttattactg 115620gatcaacatt tctcactatc tgcttcctcc gccaattaaa
atatcacttt acaagatgtc 115680tgaataggaa tagctccagt ctgcagctcc cagcatgatc
gacgcagaag atggtgattt 115740ccgcatttcc aactgaggta cctggttcat ctcatcggga
ctggttggac agggggtgca 115800gcccacagag ggcaagttga agcagggcgg ggcatcacct
cacccaggaa gcacaagggg 115860tcaggggatt tccctttccc agccaaggga agccatgaca
gactgtacct ggaaaatcag 115920gacacttttg cccaaatact gtgcttttcc aacagtctta
ccaaatggca caccaggaga 115980ttatatccca tgtctggctt ggcaggtccc acacccacgg
agccctgctc actgctagca 116040cagcagccta agatccaccc gtgaggcagc agcctggcag
gcggaggggc gtccgccatt 116100gctgaggctt gagtaggtaa acaaagtggc cagggaagct
cgaactgggt ggagcccacc 116160acagctctgc aaggcctgct gcctttgtag accacacctc
tgggggcagg gcatagctga 116220aaaggcagca gaaacttctg cagacttaaa cgtccctgtc
tgacagctct gaagagagca 116280gtgtttctac cagcatggtg tttgagctct gacaatggac
agactgcctc aggtggatcc 116340ctgatgcttc tgtagcctaa gtgggagaca cctcccagta
gaggccaact gacacctcat 116400acaggtgggt gcctgtctgg gacgaagctt ccagaggaag
gatcaggcag caacattggc 116460tgttctgcaa tatttgctgt tctgcagcct ccactgcaga
taccgaggca aacagagtct 116520ggagtggacc tccagcaaac tccaagagac ctgcagctga
gggacctgac tgttagaaag 116580aaaactaaca aacagaaagg aatagcatca acatcaacaa
aaagggcatc cacaccaaaa 116640ccccatctgt aggttaccag caccaaagac caaaagtaga
taaaaccaca aagatgggga 116700gaaaccagag cagaaaagct gaaaattcta aaaaccagag
ggcctcttct cctccaaagg 116760attgcagctc cttgccagct ggatggagaa tgactttgac
gagctgacag aagtaggctt 116820cagaaggttg gtaataacaa acttctccaa gctaaaggag
gatgttcaaa cccatcgcaa 116880ggaagctaaa aaccttgaaa aaagattaga ccaatggcta
actacaataa acagtgtaga 116940gaagacctta aatgacctga tggagctgaa aaccatggca
tgagaactac aggacgcatg 117000cacaagcttc actagccgac ttgatcaagt ggaagaaagg
gtatcagtga ttgaagatca 117060aattaatgaa ataaagcgag aggagaagtt tagagaaaaa
agagtaaaaa gcaacaagat 117120aaagcctaca agaaatacag gactatgtga aaagaccaaa
tctacatttg attgttgtac 117180ctgaaagtga cggggagaat ggaaccaagc tggaaaacac
tcttcaggat attatccagg 117240agaacttccc cgacctacca aggcaggcca acattcaaat
tcaggaaata cagagaactc 117300cacaaagata ctcctcgaga agagcaaccc caagacacgt
aattgtcata ttcaccaagg 117360ttgaaatgaa ggaaaaaaat gttaagggca gccagagaga
aatgtcgggt tgcccacaaa 117420gggaagccca tcagactaac agcggatctc tcagcagaaa
ctctacaagc cagaagagag 117480tggaggccaa tattcaacat tcttagagaa aaagactttt
caacccagaa tttcatatcc 117540agccacacta agcttcataa gtgaaggaga aataaaatcc
tttacagaca agcaaatgct 117600gagagatttt gtcattacca ggcctgcctt acaagatctc
ctgaaggaag cactaaacat 117660ggaaaggaac aaccagtagc agccactgca aaaacatacc
aaattgtaaa gaccatcgat 117720gataggaaga aacagcatca actaacgggc aaaataacca
gctaacatca taataacagg 117780ttcaaattca cacataacaa tattaacctt aaatgtaaat
gggatgaatg ccccaattaa 117840aaaacacaaa ctggcaaatt ggataaagat tgaagaccca
tcactgtgct gtattcagga 117900gaccaatctc atgtgcagag aaacacatgg gctcaaaata
aagggatgga ggaagatcta 117960ccaagcaaag ggaaagcaaa aaaaaaaaaa aaaaaaaaaa
aaaaaaaaaa agcaggagtt 118020gcaatcccgg tctctgaaaa aaaagacttt aagccaacaa
agatcaaaag agacaaaaaa 118080ggccattaca taatggtaaa aggatcaact gggcaagaag
agctaactat actaaatata 118140taggtaccca atacagcagc accaagattc ataaagcaag
tccttagaga cctataaaga 118200gacttagact cccacacaat aataatggga gactttaaca
cctctctgtc aataatagac 118260agatcaatga gacagaaggt taacaaggat atccaggaca
tgaactcagc tctgcaccat 118320gtgaacctaa tagacatcta cagaaccctc caccccaaat
caacagaata tacattcttc 118380tcagcacgac atcacactta ttccaaaata gaccacatag
aagtaaagca cttctcacca 118440aacgtaaaag aacagatatc acaacaaact ggctctcaga
gcacagtgca atcaaattag 118500aactcaggac taagaaactc actcaaaacc gcacaacttc
atggaaattg aacaacctgc 118560tcctgaatga ctactgggta aataatgaaa tgaagacaga
tataaagatg ttctttgaaa 118620ccaacgagaa caaagacaca gcataccaga atctctggga
catatttaag gcagtgtgta 118680gagggaaatt tatagcacta aatgcccaca agagaaagca
ggaaagagct aaaatcgaca 118740ccttaacatc acaattaaaa gaactacaga agcaagagca
aacaaattca aaagctagca 118800gaaggcaaga aataactaag atcagagcag aactgaagga
gatagagaca caactcttca 118860aaaaatcaat gaatccagga gctggttttt caaaaagatc
aacaaaatag atacactgct 118920agcaagacta ataaagaaga aaagagagaa gaatcaaata
gagggaataa aaaatggtaa 118980aggggatatc accaccgatc ccacagaaat acaaactacc
atcagagaat actattaaca 119040cctctacaca aataaactag aaaatctaga agaaatggat
aaattcctgg acacatacac 119100cctcccaaga ctaaaccagg aagaagttga atctctgaat
agaccaataa caggctctga 119160aattgaggca ataatagcct accaaccaaa aaaagtccag
gaccagatgg actcacagcc 119220gaattctcct agaggtacaa agaggagctg ataccattcc
ttctgaaact attccaatca 119280atggaaaaag agggaatcct ccctaactca ttttatgagg
ccagcatcag cccgatacca 119340aagcctagca gagacaccac aaaaaaataa ttttagacca
atatccctga tgaacgtcga 119400tgtgaaaatc ctcaataaaa tactggcaaa cccaatccag
cagcacatcc aaaagcttat 119460caaccacgat caagtcggct tcatccctag gatgcaaggc
tggttcaaca tttgcaaatc 119520aataaacgta atccataaca taaacagaac caatgacaaa
aaccacatga ttatttcaat 119580agatgcacaa aaggtctttg acaaaattct acagcccttc
atgccaaaaa ctctcaataa 119640actaggtatt gatggaatgt atctcaaaat aataagagct
gtttatgaca aactcacagc 119700caatatcata ctgaatgggc aaaaactgga agcattccct
ttgaaaactg gcaaaagaca 119760aggatgccct ctgtcaccat tcctattcaa cactgtgtta
gaagttctgg ccagggcaat 119820caggcaagag aaagaaataa agggtattca attaggaaaa
gaggaagtca aattgtccct 119880gtttgcagat gacacgactg tatatttaga aaacttggtc
atctcagccc caaatctcct 119940taggctggta agcaacttca gcaaagtctc aggatacaaa
atcaatgtgc aaaaatcaca 120000agcattccta tacacccata acagacaaac atacagccaa
atcatgagtg aactattcac 120060aattgctaca aagagaataa aatacctggg aatccaactt
acaagagatg cgaaggacct 120120ctggacctct tcaaggaaaa ctacaaacca ctgctcaatg
aaatacaaga ggacacaaac 120180aaatggaaga acattccatg ctcatggata ggaagaatca
atatcgtgaa aatggcgata 120240ctgcccaaag taatttatag attcaatgcc atccccatca
agctaccaat gacttttttc 120300atagaactgg aaacaactac tttcaagttc atatggaacc
aaaaaagagc ctgcattgcc 120360aagaccatcc taagccaaaa gaacaaagct ggaggcatca
cactacgtaa cttcaaacta 120420tactacaagg ctaccgtaac caaaacaaca tggtactgct
acccaaacag agatagacca 120480atggaacaga acagaggcct cagaaataac accacacatc
tacaaccatc tgatctttga 120540caaacctgac aaaaacaaga aatgggaaaa ggattcctta
tttaataaat ggtgctggga 120600aaactggcta gccatatgta gaaagctgaa actggatccc
ttccttacac cttatagaaa 120660aattaattca agatggatta aagacttaaa tgttagactt
aaaaccataa aagccctaga 120720agaaagccta ggcaatacca ttcaggacat aggtgtgggc
aaggacttca tgatgaaaac 120780gccagaaaca aaggcaacca aagccaaaac agacagatgg
gatctaattc aactaaacag 120840ctgcacagca aaacaaacta ccattagagt ggacaggcaa
cctacagaat gggagaaaat 120900ttttgcaatc tacccatcag acaaagggct aatatccaaa
atctacaaag aaatttacaa 120960gaaaaaaaca accccatcaa aaagtgggca aaggatatga
acagacactt ctcaaaagaa 121020ggcatttatg cagccaacag acatataaaa aatgcttatc
atcactggtc atcagagaaa 121080tggaaatcaa aaccacaatg agataccatc tcatgccagt
tagaatggtg atcattaaaa 121140agacaggaaa caacagatgc tggagaagat gtggcgaaat
aggaacactt tcacactgtt 121200ggtgggagta gtgtaaacta gttcaaccac tgcagaagac
agtgtggcga ctcctcaagg 121260atctagaact agaaatacca tttgacccag ccatcccatt
actgggtata cacccaaagg 121320attataaatc atgctgctat aaagacacat gcccatgtat
gtttactgtg gcactattca 121380caatagcaaa gacttggaac caacccaaat gcccatcaat
gatagactgg ataagaaaat 121440atgccacaaa tatcccaagg aatactatgc agccataaac
aagggtgagt tcatgtcctt 121500tgcagggaca tggatgaagc tggaaaccat cattctcagc
aaactagcgc aaggacagaa 121560aagcaaacac tgcatgttct cactcatagg tgggagttga
acaatgagaa cacttggaca 121620catggcaggg aacatcacac aaaggggccc gggggaggga
tagcattagg agaaatacct 121680aatgtaaatg acgagttaat gggtgctgca aatcaacatg
gcacatgtat atctatgtaa 121740caaacctgca cattgtgcac atgtacccta gaacttaaag
tataataaaa atatatatac 121800atcactttac atccaaccag cactttggct ttgaagccac
tgcctgatgt tgacactttg 121860tagatgtagt atgactattc ttatatgtct ctatctactg
atgaggatcc tactctttta 121920gtataaagag taccattgac ttccaatcaa ctagtttcga
taatatctga aagatattaa 121980ataacctgac actagcctta gtaaccgaca ccttactggc
cctactacta ctactaatta 122040catttttact tccacaaatt aatatttata tagataaatc
cagcccctat gaaggcagat 122100ttgacccaat aacctccaac tgcctcccct tttccataaa
attcttccta gtagccaaca 122160catttctcct cttagactta gaaatcgctc taatactacc
cctgccatga gctattcaaa 122220caaattacct aacaacaata atcaccacag cccttatact
agttatcatt ttaatcctag 122280gcttaattta caaaagaact caaaaagggt tagattgaat
tgaattggta aatagtttaa 122340gtcaaaagaa atgatttcga ttcattagat tataataaac
catatttacc aaatgccctc 122400tatttacatc aacattatat taccatatac catatcacta
ctggtaaaat taatctatca 122460aacccaccta atatcatccc tatgtgccta gaaggcataa
tactgtcaat atttatcata 122520attaccctta taactttaaa tatacatttt actctagcat
ctataatacc cattatcctc 122580ctagtatttg ctgcctgtga agccgcagtg ggccttgcct
tattagtttc aatctccaac 122640acatacggcc tagattacac acaaaatcta aatttacttc
agtgctaaaa attattccga 122700caattatgct gttaccaata atatgattct ctaaaaattc
tataatctga attaacatga 122760ccatccacag cctacttatc agcctcatca ccctattgtt
ttttaaccaa ttcaacagta 122820actcatccaa cttctcacta gttttctctt ctgatctgct
gatgtcaccc ctcctaattt 122880taacagccta ttacctttta taatcctagc aagccaatat
taactgttca atgaatcacc 122940cccacaaaaa agctctatat ttctatattg atttccctgc
agatttttta aaattatagc 123000attcacagcc acagaactaa ttatatttta tattttcttt
gaagccacac taattcctac 123060cctaattatt attatcaccc gctgagggaa ccaaccagaa
cgcctcaatg caagctcata 123120tttcctattg tacacactag tagggtccct tcctctactt
gttacacttg tctacacttt 123180aaatacttca gattctctaa atatgctagt aatgatattt
actgaccaag aactgttagc 123240ctccttatcc aataatctta tatgactagc atgtattatg
gcctttatag taaaaataac 123300tctattcgga cttcacctgt gactcccaaa agcccatgta
gaagccccta ttgccggctc 123360aacagtactt gcagcggtac tcctaaaact aggcggctgc
ggtataatac ggcttaccct 123420tatcctcagc cccctaacag aatatatagc ctaccccttc
ctcacactat ccctatgagg 123480gatagttatg acaagctcca tttgtctaca aaccgatgta
aaatcagtta ttgcctactc 123540ctctgtaagc catataccac ttgtcatcat agctctccta
atccaaaccc cttgaagctt 123600tacaggtgcc gtcaccctta taattaccca tggagtcact
tcatccctgt tattctgcct 123660agcaaattcc aactacgagt gagtccaaaa cggaatcata
tacttacctg aggccttcaa 123720atactcctcc cactgatata gcctcatgat gacttctagc
aaatctcact aatcttgcct 123780tacccctacc attaatctag taagggaact ctctgtgatc
atggcttcat tctcctgatc 123840aaacatcact attatgctta caggacttaa tatactaatt
acaaccctct actccctaca 123900tgtaccaatc acaacacaat gagggacact tacatattac
attaacagtt aaaccttcct 123960ttacacgaga aaatacatta atatttatac atgttacacc
tattcttcta ttatcctaaa 124020tcctaaaatt attatgggct ttacatgctg tagctatagt
ttaaccaaaa cattaaattg 124080tggatctaat aatagaagcc tgcaacttct tatctaccaa
gaaagtatgc aagaactgct 124140aactcatgcc cccatgccta acaatatggc tttctcaact
tttaaaggat tggagtcatc 124200cgttggcctt aggaaccaaa aacattggtg caactccaaa
gaaaagtaac aaatatgtat 124260ttttccacta ctataatagc cctaatcgcc ttaatcacac
caattattac gttagtcaac 124320ccctgcaaaa gaagattcat acccaaatta cataaaaata
gccatcacat gcgccttcac 124380cattagcctc atcccaacgt ttatatatac agaccaagaa
gtcattatct caaactgaca 124440ttgaatgaca atcccaactc ttaaactctc actaagcttt
agactacttc tccataatat 124500ttattctagt agcactattt gttacctgta gaattctcaa
tatgatatat aaactcagac 124560cctaacatta atcaattttt caaatatttt cctcatcaca
gtattcttcc aatattccac 124620caacaaactc tttcaactct ttatcggatg agaaggtata
ggaatcatgt ctttcttact 124680aactggctga caatatggcc gagcagatgc taatacagca
gccctccaag cagtcctgca 124740caatcgcatc ggcgacattg gttttatttt agttatagca
tggttcctct tttcctccaa 124800cacatgagag attcaacaag cattcattct aaaccctacc
tctaatcccc ttccattaat 124860tcgccttctc ttagcagcag caggaaagtc agctaaattc
ggcctccatc cctgacttcc 124920atccgccata gaaggcccaa ccccagcctc agccctgctc
cactccagca ctatagttgt 124980agcaggagtt ttcctgctca tccgcttcta ccctttaata
gaaaataacc tctgaaccca 125040aacctttaca ttatctccag gggctgttac caccttattt
acagcaatct gcgctctaac 125100acaaaatgat atttaaaaaa tcatagcatt ctccacctca
agtcagctgg gccttacgat 125160agtcacaatt ggcattaatc agccacatct agcattcctt
cacatgtgca cccacacctt 125220ttttaaagct atattattta tatgctcagg ctccatcatc
cacaatctca atgatgaaca 125280agatatttga aaaataggac tattcaagac tttacccttc
acttcctctt cccttattat 125340tggtagcctt gcacttacag atatgccttt cttcacaggc
ttttactcta aagaccttat 125400tatcgaaacc acaaatactg tcatatacca acgcctgagc
cctttctatt actcttactg 125460ccacctcctt aactgctggc tatagtaccc gtgttatttt
ctttgctctg cggactggcc 125520atgcaggagt ggtaagggcc cgggccacgc gcgacgcctg
ggggccctgc tgcatcgccc 125580gtttgttcgg ggaaggtggg ggggacgctt catgccgccg
cgcccagcag ggtttccatg 125640tctgagatgc ccgctctggc cccaagagaa tgaaccagcc
gcagaggatg gcatccgtgg 125700acacggacaa ggagctcagt aacctggact tcagcatgat
gttcccgctg cccgttgcca 125760acgggaaggg ccggcccgcc tccctggccg gggcgcaatt
cagaggttca ggtcttgaga 125820actggcccag ctcaggctcc tggggcagcg gcgaccagaa
cagctcctcc tttgacccca 125880gctggacgtt cagcgaaggc gctcaacttg ctgagtcgca
cggcagccac tctccattca 125940cattcctggg accgggactc ggaggcaaga gcagctagcg
cgggcctatt cctcctttgg 126000tagagacgca ggcgtgcgca gcctgactca ggctggcttc
ctgccgggca agctggccct 126060cagcagcccc ggacccctgt ccccctcagg catgaagggg
acctcccggt actacccctc 126120ctacgccagc agctctggcg gacagaggcg gacagcggcc
tggacacgca gcccacgaag 126180gtcgggaagg tcccgcctgg tcttccatcc tcggcgtacc
tgcccagctc aggtgaggag 126240tacggtaggg atgccgccgc ctatccatcc gccaagacgc
ccagcagcgc ctgtcccgcc 126300cccttctaca tggcagatgg cagcctgcac ccctaagccg
agctctggag ttccctgggc 126360caggtgggct ttggccccat gctgggcggg ggctcatgcc
cctcgtccct cccgcccagc 126420agcggccctg tgggcagtgg cggaggcagc agcacgtttg
gcggcctgca ccagcacgag 126480cgcgtgggct accggctgca cggaggagaa gtgaacggtg
ggcttccggc tgcatccacc 126540ttctccttgg cccccggagc cacgtaggcg gcgtctccag
ccacacgcct gtcggcgggg 126600ccgacaacct cctgggctcc cgagggacca cagccagcag
ctctggggac gccctcggga 126660aggcctggcc tcaatctact ctccggatca ctcaagcaat
aacttgtggt ccagcccctc 126720caccgccgtg ggctcccccc agggcctggg agggacgtcg
cactagcctg gagcaggagt 126780ccctggtgcc ttatcaccca gctacgacgg gggtctccac
ggcctggaga gtaagataga 126840agaccaccta cctgaacgag ggcatccacg tgctctgcag
ccacgccatg ggcacggcta 126900gcaacgtgca cacgctgcta cccggccacc gggcgctggc
cttgggcttc gccggcccca 126960tgctgctggt gggggcagca cgcaggcctg gttggaggcg
aacaccctga ggacggccct 127020gcgggcagcg ccagcctcat gcacatccat gttgccctct
ccagctagcc aggcgccctc 127080cccgacctct cttggccttc cgactcctgc agtgggctag
ggcgagcagg ccactgggga 127140aatcaagcgg gaggaggagg atgaggagaa cacgtcggcg
gctgaccact caagaggaga 127200agaaggagct gaaggacccc cgggaccgga ccagcccaga
caaggacgag gaggaagatg 127260accttttccc cccagagcag aaggccgagt gggagaagca
ggtggccaat aacgccaggg 127320agcggctgcg ggtcccttaa gagggctctt aaggagctgg
ggcgcatgtg gcaactgcac 127380ctcaacagcg agaagcccca gaccaaactc cttatcctgc
accaggccgt ctcggtcatc 127440ctgaatttgg agcagcaagt gcgagagcgg aacctgaatc
ccaaaacagc ctgtttgaaa 127500cggcgagaag agaaggtgtc gcgcgtgttc ggaggccccc
agatggtgct ttcagctgcc 127560cacctgggct tgagtgaagc ccacaacccc gctgggcacg
tgtgaaaggt acgcctccgt 127620gggacgagcc acccgccctc agccccgtgg gctgggccca
gaacgcccac ttgaggccct 127680gggcttcatc cacatccaca cctcacacaa ctgttgtcag
cattgagcca acaccgacct 127740gatgaggctc agagtgatgg gggcaaggaa ggtgagtgat
gggggtgagg aaggtgacgc 127800tgggtccagg agctccctgg gaccccggct cacccctcac
tgccctcgct ccccctgccc 127860ccgtatctca gccaccatgt caccctgtga cctgccccat
ggaccctgaa actgcatctt 127920ggccctgttg tctgggctgg caggagcttt tttttttttt
tttttttttt tttttccagt 127980aaacaaaacc tgaatgcaag caacaaaaca tacactttgt
cagaaaagaa aaaaatgcct 128040taactataaa atgtggagaa atcgtaacat atcacttgag
ggagatgctg tggaaacttg 128100gcttattctt caaaagccag cagcaaattg tgcctaagcg
taattttttt taaggaaaat 128160aaaaagaaca ttagttattt aaaaaaaaaa aaaaaaaaaa
aaaaacccgg actgaccttg 128220gccaggctgg atcagactgg cctagagtag acttcagagg
gtgactcccc tggtgggctg 128280gtctcagctg atcttgactg tcccgcctcc acacagggcc
catccatctt ccccttgatc 128340ccctgctgca aagacattgc ctctgatgcc acctccatga
acctgggctg cctggccaca 128400ggctacttcc tgaagtcagt gactgtgacc tgggacacag
gctccctcaa caggagcgct 128460gggaccttcc cagccaccac cctcacgccc tctggccatt
acgccatcac cagccagctg 128520actgcctcgg gtgcgtgggc caaacgctca cctgcagcgt
ggcacacact ctgtggtccg 128580cagaccaggt cagtaccttc agcatctact ccagggactt
caccctcccc accgtgaaga 128640tcttacagtc ctcctgtgat ggcagtggac acttaccccc
gaccatccag ttcctgtgcc 128700tcatctctgg gtacacccag gtgccatcag catcacctgg
ctggaggatg ggcaggtcgt 128760ggatgtgaac tggtccatcg cctctcccat actggaggat
gagctggcct ccacacaaag 128820caagctcacc ctcacccaga agcgctggct gcccgaccac
acctacacct gccaggtcac 128880ctatcaaggt aacacctttg aggacagtgc caagaagtgt
gcagattcta acccgcaagg 128940ggtgagcacc tacctgagcc ggtccagccc cttctacctg
ttcatccgca agttgcccac 129000aatcacctgt ctggtggtgg acctggcacc cagcaaggag
aacgtgaagc tgacttggtc 129060ccaggccagt gggaagtctg tggctcaggt catcctaagg
caagagaagc agtgcaatgg 129120cacgttcacc atcacgtcca ccctgctggt gggcaccaga
gactggatca agggggagac 129180ctaccagtgc agggtgaccc acacccacct gcagtccacg
accaagatca gcggcccatg 129240tgctccccca caggtctacg tgtttgcaac gctagaagag
ccgaggaacc aggacaagcg 129300caccctcacc tgcctgatcc agaacttctg gcccaaggac
atcttggtgc agtggctgta 129360caacgaggtg cagctcccgg acacttggca cagcatgacg
cagccccgca aaaccaaggg 129420ctctggcgtc ttagtcttca gctgcctgga ggttaccagg
gctgaatggg aacagaaaaa 129480cgagttcatc tgctctgtgg tccatgagac agcgactggc
tcacagaccg tcaagtaact 129540gttgtctgta aatcccatta aatgtcctcc tgccttcctc
cccactaggg ctctgtccag 129600ctgtgtggtg ggaagggctg gccagacctt ctgtccactg
ttgcaatgac cccaggaagc 129660cacccccaat aaacagtgcc tgctcagaaa acaaacaaac
aaacaaacaa acataaaaac 129720cctagaggaa aacctaggca ataccattca ggacataggc
atgggcaagg acttcatgac 129780taaaacacca aaagcaatgg caacaaaagc caaaatagac
agatgggatc taattaaact 129840aaacagctgc atagcaaaag aaactgatca gagtgaacag
gctacctaca gaatgggaaa 129900aattttttgc aatctagcca cctgacaaaa ggctaatatc
aagaatctac aaagaactta 129960aacaagttca caagaaaaaa acaaccccat caaaaagtgg
gtaaaggata tgaacagaca 130020cttctcaaaa gaagacattt atgtggccaa caaacatatg
aaaaaaagct catcatcact 130080ggtcatcaga gaaatgcaaa tcaaaaccag agtgaggtac
catctcatgc cagttagaat 130140ggcgatcatt aaaaagtcag gcaacaacag atgctgaaga
ggatgtggaa aaacaggaat 130200gcttttacat tgttgatggg agtgtaaatt agttcaacca
ttgtggaaga cagtgtggca 130260attcctccag gatccagagt tagaaatacc atttcactga
gcaattccat tactgggtat 130320atacccaaag gattataaat cattctacta taaagacaca
tgcacatgta tgtttattgt 130380ggcacttttc acaatagcaa agacttggaa ccaacccaaa
tgcccatcaa tgatagactg 130440gataaagaaa atgtgacaca tatacaccat ggaatactat
gcagccataa acaaggatga 130500gttcatgtcc tttgcaggga caaagatgaa gctagaaacc
ataattctca gcaaacacag 130560gaacagaaaa ccatacacca cttgttctcg ctgataagtg
ggagttgaac aatgacaaca 130620tatggacaca gggaggggaa catcacacac cagggcctgt
tgttgggtgg agggctaggg 130680gagggatagc tttaagagaa atacctaatg tagttgatgg
gttgatgggt gcagcaaacc 130740accatgacac gtgtatacct acgttaacaa acctgcacct
tctgcacatg tatcccaaaa 130800cttaaagtat aataaaattt aaaaaaaaaa cagtgaacat
ttattgtagg cttacattgg 130860gctaaatgca ttttatggat aatctcattt aatcctcata
acaacccttg gagaacatgt 130920atgattatta tctctatttt aagcatggag aactgaatag
cttacccaag gtggcatgac 130980tagtaaatca ctggaccagg atttaaaccc aaaaagtctg
atcccagagt tcatgcttat 131040aagccttcct aaccatgata atgctttaat ctggcattaa
ttgttctcta atttgggtag 131100gtttgaaatt tttcataata aatattaaaa atactttttg
aggaaatgtc gtcatgataa 131160acattagaac tgcgttcatc taattacttt tagggtatga
gtgaaactaa aaagtaagac 131220tcatctaaaa ataatcatct gttttggcca tatccccagt
gatacatgaa tttaattgtt 131280tttattgttt tcagaatgaa aaattaaaga ggttaaataa
aattagctgg caatcaaaaa 131340atattagtta tatgaagatt cagagatttg gttatactta
atgaatacaa gctaataaat 131400atttattaag actctactgt gctccaaata ctatacaggg
aggtagggat atgaagatag 131460gcttagcatc agaaaaggac tgtcccttag tagaaaggct
gaactaaaag gaaaagtttg 131520acgtgatagg caaattcaac tgacaggtcc actacccata
gtcccttcaa gagctcataa 131580ttaggaaaag tcatatgtat aatatggcac tttcaataat
taagtgcaat aagtgtaagt 131640gcaataatta aggtactggg aaaacataac agtacaaata
attcagctga agatttatgt 131700aagataacta agatgacatt tcaacgattg gttgaattga
cctctccctc atgaatggga 131760ttaaggccct tataagaggc ttcatgcagc atttggctcc
tcttgccttt ccactttcat 131820ccatgtgagg acacggcatt cctctcctct aaaagatgtg
gcaacaaggc tccccttgga 131880agcagagagc agccctcacc acacacctga acctgccagc
acctttatca tggactccca 131940acctccagaa gtatgagaaa taaatttctg ttctttataa
attatccatt gtcaggtact 132000ctgttatagc agcatacatg gacgcccagt acatcatgtt
aatgagttca gaccttcttt 132060agtagacagt gcgtaaggtg ggaaattaga ggctttatcc
aggggaataa catggtgaga 132120ttcatatttt agaaagatag ctctactttt gttatagaac
agcagttctg aaagtgtggg 132180gactttaggg tgtctgtgaa gtaaaaaata ttttcataat
aatggatgtt atttgctctt 132240ttcactcatt ttttcataag tatagttttc cagaggcaat
aagatatgtt ttctatttaa 132300ccaaacattg aagagacttg caaaaatgta aaacaatgtg
actcttatca aagtttattt 132360tggaaatagt tgttttccat aaaatacatt acttatgtta
acaggtaatg gttttatctt 132420aaataaatta ataaatattt ttatatttta ttagctttaa
tatttaatat ggtaaatact 132480ggtagatata actcacagaa acaaaagttt tttggcaacc
tcagtaattt ttaagagtat 132540acgaggaagc ctgagatcaa aagctttgag aactactgac
agaggggacg ttgtattaat 132600gagaggctaa tagtagagag gcagctaatt agattttatg
aggatctagg ccactggttt 132660tcaaaccttt taagtatata tgctcactaa aagaatttag
aaaaaccaca tcctcttaca 132720catttttaaa ttgatagcta atttttttct ttgtaagtag
ttataatgta ttttctaaag 132780tactgtaaat attgacattt aaataacagc tatgtcaatc
ctttaaatgt gtccaactga 132840atctaaatag tgcttgcagt gagcggagac ctcgccactg
cactccagcc tgggcgacag 132900agcgagactc catctcaaac aaacaaataa atagtgcagc
aatttgatac ccacttatca 132960cccacttaaa aagattatat gaatagactt ttattttttt
gtacaaactt tgtatcattc 133020ctttttctct ttaaaatagt attcccactt cccttctcat
tccaaatttt gcataatatg 133080ttacactttg tatttggata atcttatgat cacctatttt
ctttgtaacc aagatatgta 133140tataagtaag ttgaaattaa ttaaaaattt tcctgtgacc
aacaaacttg taactattca 133200catttttctt ctgggttatc attgaagtta ctaggataca
gttttccaaa gcaatgtaaa 133260taacaaattt ggataattgc tttaaaaatt ttattggtga
atggaacaat ccctcccctc 133320caattggttt gtatatcctc ggatgaatat tatttatttc
tataatggga caagattaag 133380cataaattct gtgttcattt tgcactttac agatgtaaac
gctgagaaaa cttgtttgtg 133440taagtgagtg gacaggaatg gaaggagttt tgttataata
gtatcattca tttctatgac 133500gccttctgag atatgcagga aaaaagtaca gtaatatacc
attaaaaatt atctgttatt 133560gggcagtttc atttgatcag atccattatg tttcaatttt
attaaaagca gagaattaaa 133620accacttgac tttcaaaaat gagtttacta accagtcatc
aggttcatct gttttctcaa 133680tttctgaaaa gtataccaaa aagcttttaa aattaattcc
aactatatgt tacactttca 133740cgtggatgta ccttgtttaa actaatacat tcagaaaagt
ttgaaaaaac agactattat 133800taatacatta ttattaacat attttatcat gttttaaata
tatgatttaa acacagcaaa 133860cctctcagct acctcaaagg ttgagtagat tttgtgaaga
atgtccttca tacaacccat 133920ttggtaatgc caggcatcaa acaaatcact taatttctgg
cagaaaaact cagacttcat 133980ttttcaagtc actaaatata ttaataatat gtgatttttt
taaaacctga gaaacaaatg 134040acagaacaaa tgcatggagg tatgtttatt atgaagctaa
tgaagcatat ccagaggtcc 134100tccttccaag gttcctttct aattttaaat agaaaattat
gcactttcat gtataatttt 134160gtattctttg tcataatgaa agcctaaaaa aaaaaggctt
caaattatat aagctttggg 134220acctgtatct ctgcctatac atgtgaaaaa atcatgaggg
cagtcaggat aagctgaaga 134280tgatatatat atctggcata attaatttca tattatgaaa
ataagataat ttctcattac 134340ttaatttgca ataaataata cagagtaaaa tatggctaag
attataactt atgaagtaag 134400gtatatggta catggcatgg tcattccttc agtaaatgtg
ttagggggag gtatgaagtg 134460aattctgact ttggggaata attagaagca acttgtatga
aaatcagaaa taacttattt 134520ttcctcatga tcaaaatttt catatgtact taatgaacac
aaaaaatata tactgctaaa 134580agcaaatcag gcagttagca tatagtttta tttttatatt
tgcaagtaga aaataaatat 134640tttatacaat gaaatgaagt tcattaaatt ttatgtaaat
attttagaat atgaattgat 134700aaaataagtt tgagctaact tattgaataa taaacactgt
cttagtccct ttatgctgct 134760ataacagaat acctgaaaat ggataattta taaagaacag
aaatttattt ctcacacttc 134820tagaggttag gagtccatga aaaaagtgct ggcaggttca
ggcgtctggt gagagctgct 134880ctcttctttc caagatggag ccttgctgct tcctccttca
gagaggagga acaccatgtc 134940ctcacatgga caaaagtgga agggcgagag gggccaaatg
ctgcatgaag cctctcataa 135000gggccttaat cctattcatg agggagaagc cctcatggcg
taatcatctc ttaaaggccc 135060cacctgttaa taccatcaca ttaacaacac ctgaattttg
gaggagacac atagcaaaca 135120ctaaatctga agtctgaaag aactcaattt ttattcacag
gattttgccc atgatatcat 135180ttttttaaaa actcaatttc atttaaaaga aactttgtta
tctatattgt ttttcttgtt 135240cgaaaaggct cttttgtttt aagctaacaa tatggttgac
ggtaataact gggggaaaaa 135300gtgcctctgc ttaaatgttg taaaaaatcg gtgaaacagg
attttggact cctggaggat 135360cctttactct ttttactaca gaagtaccca ttggatgatc
tttgtacatt attcttcacc 135420ttgtgtgaag acctctgtgc tagtcatgag ataaggatgt
gatgtaaact gtaacaatgg 135480gttaggagac tgattggaga tatttctaag ctatactcta
aagggactta gtgggtcatt 135540agacactgga gtgaaagatg cgtcaaaaat aattaagatt
ttcaaattga gcagctaaat 135600agattgtgat gctatttatt gcataagaaa caaaataatc
agcaagtttt ggaaagagga 135660tggaattctg tttgcctata gatctttaat gtggaaatgt
tctaaaagtc tggagcacta 135720aacaaaggtc aaagatatgg ttataaattt gggagacttt
agtatatagg tggatgatac 135780tatctaaggg aaagttttta accaagagag gaataaatct
gatgaagaga ccctgggaaa 135840ccttcaattt agaagaggca gaatagtagt agtagtgttg
ggaaagtata attgaaaaca 135900aaatcttcca acccagaaaa cctttccaca aagatagaag
gaaaacaatt ttatgattga 135960gtaagcatta gagcaggatg tgatgtgtat cacaagcagt
cccctaagag atttgcaaag 136020acagaaggaa atctcaccct tttatatagc caacctgata
taaccccttt cattcaagtt 136080cttaggataa acattaacta gtcctcaagt aagaagactt
gacagcacta tttgccacat 136140acgtagttta ttctaaattc acttggtaat tggagtgact
ttgctaattg gctttataca 136200aaggaaaata cacttttcat atcttcatga caggaggtag
ttttgcagct tggaaggagg 136260ctcctgctga agttaggctt ctactcccac agaaactggg
agtaagggtg ctatcttcct 136320tgatgactga attcccaaga gatagttaca cgttcttgag
aaagacattc atgggtcaca 136380aaactggcaa gaggctttga agcaagagat ttttaaaaga
tttacataca cttcaaaaag 136440acaaagaatt tacaagtttt ctgaatgctc taagaacaaa
gaaggaggag tctttcttct 136500tattttcaac aaggggaatt aattttgttc tttttaaatt
tgtatttacc cttacataag 136560tgatagaaca gacagaaaaa aacagctgtg gaaatgtgcg
ggaaattaca atgagtgcta 136620tatgaaaacc agaggaagag catattttgc aaggagtgag
ggaatagtgc tgtcttcaag 136680aactttgcat tccccttgtg gaataaaact aacatacatt
tgataataac ataactagat 136740atgtaaaatt tgtaaagact aaatgtaaaa agaatatagc
attaggatgt ttaattacgt 136800agtatggact gccagtacta taggaattca gtggcctgag
ggcaataaga cctggagtag 136860gcagggaagg atttgtggag attaggaaac ttaaatggga
ttttgaagga gagattaaat 136920ctatgtaatt cacattttta atatcagtct aaaacacatc
tctgtagctg tctctataat 136980aaagataaac ttagcaatgg aaccatgata ctcacagtcc
actaggccaa aacgttccct 137040tggatagtgt taatgcttga gtgaacaatg acaccattgc
tgtgactttt tcctttctgt 137100attccttagt cacccctctt ctggttaaca ggttctttct
tttatagctt taagtcttgc 137160cttggaacca atttttttct ccagcatatt tatatggatt
catttaaagc ttaacttgca 137220aagagcagct tattttcact tcttagaagg tactctgcag
ttaaccttgg tgctgtctac 137280agagacaaaa ataaatttct ttggatttta gttatctttc
tatgtcagag attcccaaga 137340ccatccccag gttgacgatt tgctaggaag actcacagga
ctcagcatat atccatattc 137400atggttatga ttcattatag ggaaataaca taaagcaaaa
ttaggcactc tccgcctggc 137460acatactaaa gttacatact cccagaagaa aagtagatgt
cagcataaac cgtattgttt 137520gtacaaacaa tctaggcata gtgagtcact cttatttagg
gaattgtgga atccctcctg 137580aaatctaagt tcacaggtgc caggcaaaaa ggccctttta
atcatagaag cctcaggcct 137640gctgtgataa ctcttttctc tacatgtttt tttttttaat
ttatacaatg atttgcaggt 137700aaaatcaaga gtccacatat caagtaactg tcttttaaat
gttattcata tatttacagg 137760tatgctccag aatcactgac agagagcaag ttttctgtgg
cctcagatgt ttggagcttt 137820ggagtggttc tgtatgaact tttcacatac attgagaaga
gtaaaagtcc accagcggtc 137880agtgtgcttt ttatttactt tcagtttttt gtttgttcgt
ttgattttta taaatttatg 137940gggtacaagt acaattttgc tacatgcata cattgcatag
tggtgaagtc agagctttta 138000gggtatccac caccttaata acatacattg tatcccttaa
ataatttctc agcatctact 138060ccaccaatgg ctcacccttc caagtctcta ttgtctatca
ttccacattc tacgttcatg 138120tgtatacatt atatagctcc cgcttataag tgaaaacgtg
gtatttgtct ttctatggct 138180gatttgtttc acttaagata attacctcca tccatgttgc
tacaaaagac ataatttcat 138240tcgttgttat ggctgaatag tattccattt tgtatgtata
ccacattttc tttatccagt 138300catccactga tggacactta ggttgattcc atgtctttgc
ttttgtgaag aatgctgcaa 138360taaacataca ggtggaggta tctttttgat acagtgattt
cttgtccttt aggtagatac 138420cccatagtgg gaatgctgga tcgaatggta gttctatatt
taggtctctg agaaatcttt 138480ataatgtttt ccatagaggt tgtacaaatg cacattctca
ccaacagtgt ataagagttc 138540ccttttctcc acacccttgc caacatctgt tattttttct
ctctctcatt tttttttcca 138600ttctgactgg agtcagacat atctcactgg ggtaattttt
tctctttttt ttttttgtca 138660ttctgactgg aataaggcat atctcattgt gattttaatt
tgcatttctc tggtgattag 138720tgattagcat tttttcatat gcctcttgtc agtttgggtg
tcttcttttg aaaatgtcta 138780ttgatctcct ttgtccactt tttaacacga ttattagggg
gttttggttg aattgcttga 138840gttccttata aattctggat ggtagttcct tgtcagatac
aaagtttgca aatattttct 138900ccgattatgc aggttttctg ttcattctgt tgattattga
ttttgctatg ctgaaatttt 138960ttagcttaat aaagtctcat ttgtctattt ttggttttgt
tgcctatgct tttgaggtct 139020ttgccatgaa ttctttgttt acactcattt ccattaaagt
tttctctagg ttttttttct 139080agtatttttc tagtttcaga tcttacattt aagtctgtaa
tcgatcgagt taatttttct 139140atatggtgat aaatatgggt ccagtttcat tcttctgcat
atggcaatcc aatttaccag 139200caccatttat tgaaaagggt gtcctttccc atactgcgca
aagcaatctg cagattcaat 139260gcagttccta tcaaaatacc aatgtcattt gttcacagaa
ttagaaaaaa caatcctaaa 139320attcataggg aaccaaaaag agccctaata gcaaaagcga
ttctaagcaa aaagaacaaa 139380gctggaagca tcacattact tgacctcaaa ttatattata
aggctacagt aaccaaagca 139440gcatggtact catataaaaa acaaacacat agatcaatgg
aacagaatag aaaacccaga 139500aataaagcca caaatttata gccaactgat ctttgacaaa
atcaacaaga acatacattc 139560aagttttttt ttaacatgag aaaggattta tccaaagaat
agtaagccta ggactcactt 139620tagagctttt attgcttatt tttaaggcaa tatcaaacaa
aataatccca aacctattcc 139680taaactagct tgaattttta aaaaggggat attgggaagc
tagttagtac agtctcttaa 139740tattactttt attaaatcca gtaagctaat tcattctagg
aattattgca taagttaaaa 139800taaaccttcc aaagtaattt ttctcttggt catcatagaa
ttttttttaa tatggaaaag 139860tatgaaaaaa taaaaatcat ctctaatgca attactcaga
gaagaccacc tcaatattgt 139920ggtatgttac ctttcaggct tcattttgtg tataaaagta
tatacaaaga agtatataaa 139980acttttataa cttttataaa agttcactta tataaatata
tattatttta taaaattaag 140040gtcatactgt gcagtttgct ctccttctgt ttcatgaagt
attacagcat gggtaattta 140100ctgtattaga aaaatgtact gcaaatatgt tttctaattg
ctgagtagca ttccatcata 140160aggctatata tgtctgaaca atcattttcc attcttcagt
cttttaagta acacttcagt 140220gaacatagtg aacatcctca tgcataaata tttatattta
tctctgataa ttatcttaga 140280ataaaagtat aagtaaaagt tatgaactat tttaaaattt
ttttaatttc aaaatgcttt 140340ctagaaaagc tgtgccaaat tatatctcaa cagcaatgca
tagggatgta catttcatca 140400tttgccacta ttggttatta tatttttatg tacttttgcc
aagttgatag gggagaagtt 140460atatatattt taatttccat ttcttttctt aatgtggttg
actatatatt tgttgggtgt 140520ttagggtggg tatgtatata tgtgaattat ctcttctgtg
ctttgcctat ctttatattt 140580gtaatttttt ttcccaattt ataagagctg tctatattga
aaataagtaa atgatgttta 140640agtattttcc tagcttataa ttcagatttt aattttataa
actttgacat atgaaagttt 140700tctttgttgt atttatgctt attcattcat tttttcttat
attctctttt atattcaact 140760ttttatttca attgaaatgt aatatgataa aaatatgagt
tttttaacaa caaaaaactc 140820aaaggaaata tgtttttagt tcatgtgttt tgagccctcc
tcaggggatt tgtgttgagt 140880ttattacagc tatggaaatg gaaattatag aagttccata
tttaacagcc ttatgttttt 140940gatcctaaaa gtagtttgtt ttgaaaaggt ttgaaaacat
acaaaagcac acatatacta 141000aattttttcc cattgactgg aggaaattga gaaagaattt
tgctacaaat taaatgtaca 141060aaaaatattg aaagtgggtt tgttttagga atttatgcgt
atgattggca atgacaaaca 141120aggacagatg atcgtgttcc atttgataga acttttgaag
aataatggaa gattaccaag 141180accagatgga tgcccagatg aggtaacaat ttttttttaa
tccagggtag tcatgcattt 141240tcttttactt tttactcaag gacttcagtt cacttcctga
aatttaatgt gcggagcttc 141300cagataaaca gcataatcag atgactgtgg aacaaggcat
ggttatgaca tgtgccctgt 141360attgaaaatt aatgtcttcc accaattaaa agatggccct
tagtgttcat ttaattttgg 141420tttattttct cctttacaga tctatatgat catgacagaa
tgctggaaca ataatgtaaa 141480tcaacgcccc tcctttaggg atctagctct tcgagtggat
caaataaggg ataacatggc 141540tggatgaaag aaatgacctt cattctgaga ccaaagtaga
tttacagaac aaagttttat 141600atttcacatt gctgtggact attattacat atatcattat
tatataaatc atgatgctag 141660ccagcaaaga tgtgaaaata tctgctcaaa actttcaaag
tttagtaagt ttttcttcat 141720gaggccacca gtaaaagaca ttaatgagaa ttccttagca
aggattttgt aagaagtttc 141780ttaaacattg tcagttaaca tcactcttgt ctggcaaaag
aaaaaaaata gactttttca 141840actcagcttt ttgagacctg aaaaaattat tatgtaaatt
ttgcaatgtt aaagatgcac 141900agaatatgta tgtatagttt ttaccacagt ggatgtataa
taccttggca tcttgtgtga 141960tgttttacac acatgagggc tggtgttcat taatactgtt
ttctaatttt tccatagtta 142020atctataatt aattacttca ctatacaaac aaattaagat
gttcagataa ttgaataagt 142080acctttgtgt ccttgttcat ttatatcgct ggccagcatt
ataagcaggt gtatactttt 142140agcttgtagt tccatgtact gtaaatattt ttcacataaa
gggaacaaat gtctagtttt 142200atttgtatag gaaatttccc tgaccctaaa taatacattt
tgaaatgaaa caagcttaca 142260aagatataat ctattttatt atggtttccc ttgtatctat
ttgtggtgaa tgtgtttttt 142320aaatggaact atctccaaat ttttctaaga ctactatgaa
cagttttctt ttaaaatttt 142380gagattaaga atgccaggaa tattgtcatc ctttgagctg
ctgactgcca ataacattct 142440tcgatctctg ggatttatgc tcatgaacta aatttaagct
taagccataa aatagattag 142500attgtttttt aaaaatggat agctcattaa gaagtgcagc
aggttaagaa ttttttccta 142560aagactgtat atttgagggg tttcagaatt ttgcattgca
gtcatagaag agatttattt 142620cctttttaga ggggaaatga ggtaaataag taaaaaagta
tgcttgttaa ttttattcaa 142680gaatgccagt agaaaattca taacgtgtat ctttaagaaa
aatgagcata catcttaaat 142740cttttcaatt aagtataagg ggttgttcgt tgttgtcatt
tgttatagtg ctactccact 142800ttagacacca tagctaaaat aaaatatggt gggttttgtg
tgtgtgtgtg tgtgtgtgtg 142860tgtgtgtgtg tgtgtgttat ttatacaaaa cttaaaatac
ttgctgtttt gattaaaaag 142920aaaatagttt cttacttta
14293935883DNAArtificial sequencesynthetic sequence
3ccgtccgtac tgcagagccg ctgccggagg gtcgttttaa agggcccgcg cgttgccgcc
60ccctcggccc gccatgctgc tatccgtgcc gctgctgctc ggcctcctcg gcctggccgt
120cgccgagcct gccgtctact tcaaggagca gtttctggac ggaggtaacg cctggtcccg
180cctcgaggcc gccccgacga cgcggccggc ccccgatcct ggatctgcgt tgtcgcccgt
240aattaccgtt tagaggtcca acacggtggc ctcccgggac tagagccgcg ggcgatttct
300cttctgcgtc cctggggagc gcggagggcg tagcggcctc ccgcggcggg agttagggtt
360agcccgagga tctctgaagg cacccgacgt gtcaaactag aggttggaat ggggagtgtc
420ggggatctcc tttcctgtcc ccagcagctt gtggctctcg gcagatgttt ggtgtggggg
480gggattagca cagccgctct gacctacccc tctaatcccc cacttagacg ggtggacttc
540ccgctggatc gaatccaaac acaagtcaga ttttggcaaa ttcgttctca gttccggcaa
600gttctacggt gacgaggaga aagataaagg taagagccta ggagtgggtg ctcagatccg
660ggaggacttc ctggcagaag tccttgtctg tacacacaca gccgggacag tccccttgga
720ggaggacagg tggaggaagt gggggagtct tctctattct ctaagtcgag ggtcctcgcg
780agtcaaggcc caacggtgac ctcactaccg tcccgtctca ggtttgcaga caagccagga
840tgcacgcttt tatgctctgt cggccagttt cgagcctttc agcaacaaag gccagacgct
900ggtggtgcag ttcacggtga aacatgagca gaacatcgac tgtgggggcg gctatgtgaa
960gctgtttcct aatagtttgg accagacaga catgcacgga gactcagaat acaacatcat
1020gtttggtgag ggcctgcttc ctggtgctga tctctgtccc attagttaga gggagaccca
1080gaccccattg actttcttaa taatgatttt ttttggaagg ggagctaaaa gaataagtcc
1140cagcaacaat ttattgcatt atgatcgcag atctaggctg ttaatttaat ttgcgtgttt
1200gtatatagtt atttcccaat cttactaatg aggattttga gttctagagc actgattttt
1260tttttttctc ctttaaactt aaggctccac ccacagccca ttcaggacag aatcagggtc
1320tgagtttctc ttctcagcct tgacagaccc gagttgaaga accaggtctt ccttttataa
1380agaggggtga gagcctcgag atgatgggta gtctctgact cttaactgga tctgcttcac
1440acctaggtcc cgacatctgt ggccctggca ccaagaaggt tcatgtcatc ttcaactaca
1500agggcaagaa cgtgctgatc aacaaggaca tccgttgcaa ggtgtgcctg ggggtggtgg
1560caaatggctg tcatggggag attcagaggt cagcctcatt ggggggtggc ccccgctcac
1620cttcttcctt cttcaggatg atgagtttac acacctgtac acactgattg tgcggccaga
1680caacacctat gaggtgaaga ttgacaacag ccaggtggag tccggctcct tggaagacga
1740ttgggacttc ctgccaccca agaagataaa ggatcctgat gcttcaaaac cggaagactg
1800ggatgagcgg gccaagatcg atgatcccac agactccaag cctgaggttg gtgtttgggc
1860aggggctctg ctctccacat tggagggtgt ggaagacatc tgggccaact ctgatctctt
1920catctacccc ccaggactgg gacaagcccg agcatatccc tgaccctgat gctaagaagc
1980ccgaggactg ggatgaagag atggacggag agtgggaacc cccagtgatt cagaaccctg
2040agtacaaggt gagtttgggg ctctgagcag ggctggggct cacagtgggg agtgcaccaa
2100ccttactcac ccttcggttt ccttctccct tctgcagggt gagtggaagc cccggcagat
2160cgacaaccca gattacaagg gcacttggat ccacccagaa attgacaacc ccgagtattc
2220tcccgatccc agtatctatg cctatgataa ctttggcgtg ctgggcctgg acctctggca
2280ggtgagactt ggaggaaaaa ggaggatccc tggggtacct caagtgcata agatcaccca
2340agaggaaagg gacagggtag gcaccccagg tgagtctgac tcaaaaatgg tacttcttgt
2400aaacagtact tcctggtctg tccctgtgaa gtcctcacag caaccccttt aaggttatac
2460ttgctgtgca ccaagtactt ccccaagtac ttttatgcaa atcaacttct ttacccccaa
2520agacctagaa ggtggtcagg taacccagtt agttagctgg ggctgggcac agtggctcac
2580ccttacaatc acggtacttt gggaggctga gacagaggat tgcttgaggc caggagttac
2640acaactcaac ctagcttggc aacacagcga ggagacccta tctctacaaa aaaaattttt
2700ttttttgaga cagagtttca ctcttgttgc tgaggctgga gtgcaatggc acgatctcag
2760ctcactgcgc cctccgtctc ctggtttcaa gcgattctcc tgcctcagcc tccggagtag
2820ctgggattac aggcatgtgc tactatggat gccaggctaa tttttttttt tttttttttt
2880tttgagaccg tgccttgctc tgtcgcccag gctggagtgc agtggtgtga tctctgctca
2940ctgcaagctc cgcacgaccc cccaggttca ctccattctt ctgcctcagg gtcccgagta
3000actgggacta caggcacccc ccaccatgcc tggctaattt ttttgtattt ttttttttag
3060tacagacatg gtttcaccgt gttagccagg atggtctcca tctcctgacc tcatgaacca
3120cccaccttgg cctcccaaag tgctgggatt acaggcgtga gccacctcac ccagcctttt
3180tgtagagaca gggcttcatg ttgcccaggt tggtctcgaa ctcctggcct caggtcatct
3240gcccgcctcg gcctcccaaa gtgctgggat tacaagggtt agccaccatg cctagcctct
3300acaaaaactt taaaaattgg cgagatgtca tgcatacctg tagtcccaac taccaaggaa
3360gaaggatgat cacttgagcc tggggcatcg aggctgcagt gagccatgat tatgtcactg
3420cactccagcc tcggtgacag agtgagaccc tctcaaaaaa agttgggact tggccggaca
3480cagtggctca cacctgtaat cccagcactt tgggaggcca aggcgggtgg atcacaaggt
3540caggagatgg agaccatcct ggctaacatg gtgaatgaaa ccccatctct agtaaaaata
3600caaaaaattt gccaggtgtg gtggtgggcg cctgtagtcc cagctactcg ggaggctgag
3660gcaaaaggat gacgtgaacc cgggaggcgg agcttgcagt gagctgagat catgccattg
3720cactccagcc tgggtgatag cgagactctg tcccaaaaaa aaaaaaaaat gctgggactg
3780aatttttgtc tgttttggtc actgaaatac cttctgtgcc caagacagtt ctggcatgta
3840gtaggtacct gaaaaatacc tgaataagag agtgagaaac aagaaacagg tgcagagaac
3900tgaagtcagt ggcccaaggt catgggggta ggaaaccaca aagctggggt ttgaacctgg
3960gcagtacagc acctgagtct ctccatcttt tttttttttt ttttttaaga cagagtcttg
4020ctctgtcacc caggttggag tgcagtggct tgatctcggc tcactgcagc ctctgccttc
4080caggttcaag tgattctcat gcctcatcct ctcgagcagc tggaattaca ggcatgcgcc
4140acgacgctgg gctttttttt ttttgagatg gaatttcact cttgttgccc aggctggagt
4200gcaatgatgc aatctcggcg gctcaccaca acctctgcat cccagattca agcgattctc
4260ctgcctcggc ctcctgagta gctgggatta cagggatgcg ccatcacaga ccccgggcta
4320atttttttta gtagagacag agtttcacta tgttgcccag gttggtctcg aactcctggc
4380ctcaagtgat ccgttcgcca tgacctccca aagtgctggg attacaggca tgagcccgtc
4440ccgtccctgg ctgtctctcc atctttccat cttttttttt tttttttttt tttttggaga
4500tggagtctca ctctgtcacc caggctggag tgcagtggca cgatcttggc tcactgcaag
4560ctccgcctcc tgggttcaca tcattctcct gtctcagcct cccaaatagc tgggactaca
4620ggcacttgcc accacgcctg gctgattttt tgtattttta gtagagacgg ggtttcaccg
4680tgttagccag ggtggtctcg atctcctgac ctcgtgatcc gcccaccttg gcctctgggc
4740gaggattaca ggcgtgatcc acctcacctg gcctctccat ctttttaact gcagtgtcag
4800cggtgttcct tgtcttctct gcagatgcag gcagcagaat atagtggtta taggaacaca
4860ggtggaaacc ctgtccaaag caagggctat cgggtatcac ctctgaccat ccttcccatt
4920catcctccag gtcaagtctg gcaccatctt tgacaacttc ctcatcacca acgatgaggc
4980atacgctgag gagtttggca acgagacgtg gggcgtaaca aaggtgaggc ctggtcctgg
5040tcctgatgtc gggggcgggc agggctggca gggggcaagg ccctgaggtg tgtgctctgc
5100ctgcaggcag cagagaaaca aatgaaggac aaacaggacg aggagcagag gcttaaggag
5160gaggaagaag acaagaaacg caaagaggag gaggaggcag aggacaagga ggatgatgag
5220gacaaagatg aggatgagga ggatgaggag gacaaggagg aagatgagga ggaagatgtc
5280cccggccagg ccaaggacga gctgtagaga ggcctgcctc cagggctgga ctgaggcctg
5340agcgctcctg ccgcagagct ggccgcgcca aataatgtct ctgtgagact cgagaacttt
5400catttttttc caggctggtt cggatttggg gtggattttg gttttgttcc cctcctccac
5460tctcccccac cccctccccg cccttttttt tttttttttt taaactggta ttttatcttt
5520gattctcctt cagccctcac ccctggttct catctttctt gatcaacatc ttttcttgcc
5580tctgtcccct tctctcatct cttagctccc ctccaacctg gggggcagtg gtgtggagaa
5640gccacaggcc tgagatttca tctgctctcc ttcctggagc ccagaggagg gcagcagaag
5700ggggtggtgt ctccaacccc ccagcactga ggaagaacgg ggctcttctc atttcacccc
5760tccctttctc ccctgccccc aggactgggc cacttctggg tggggcagtg ggtcccagat
5820tggctcacac tgagaatgta agaactacaa acaaaatttc tattaaatta aattttgtgt
5880ctc
5883414966DNAArtificial sequencesynthetic sequence 4gaagggagga tgggctaagg
caggcacaca gtggcggaga agatgccctc ctgggccctc 60ttcatggtca cctcctgcct
cctcctggcc cctcaaaacc tggcccaagt cagcagccaa 120ggtgaggtgc acagagggtg
gagatcacct atgcccagga agagggagcc ctgggaggtg 180atgcagggcc ccgggagggg
aggtagagta agaggctctc ctgctggtcc cctccccttc 240cacataaaca tgcctgggag
gacccagggc caactcacca gctgttcctt agatgtctcc 300ttgctggcat cagactcaga
gcccctgaag tgtttctccc gaacatttga ggacctcact 360tgcttctggg atgaggaaga
ggcagcgccc agtgggacat accagctgct gtatgcctac 420ccgcggtagg tgctggactg
tgccccactc cccatgtatc tgtccctgca cttagctgag 480tcccactcca gcagctttcc
tgcctgtccg aggaccactc tgaatacaag ccctaagtac 540ctactttttg aacagatgtg
ctttggatgt atgtgggccc cagctccagc cctacataac 600ccctaatccc acctatccca
ggcagtgaga agaaaaatgg cagtactaga gacagaagtt 660gggcatgggc ccaggtctgg
gtcctcaggg ctccgcatgg tggctgtgta ggagggacct 720cttctatgcc aacagggaga
agccccgtgc ttgccccctg agttcccaga gcatgcccca 780ctttggaacc cgatacgtgt
gccagtttcc agaccaggag gaagtgcgtc tcttctttcc 840gctgcacctc tgggtgaaga
atgtgttcct aaaccagact cggactcagc gagtcctctt 900tgtggacagt gtaggtaaga
gccatcctcc tgtcaccctg ccccctccac ttgctgcccc 960cagtccagct cccggaatca
gacttgcctg tgcccttcca gctcagcacg gataccccta 1020ttaccagacc ccctgaggca
ccccaagact cccttgtcat tcctcccagc cttggcatct 1080agagctagaa atgcccaaca
gatcattcac accctgttcc tcccatcgtc aacaaatcat 1140ttattcatcc attcaagagt
tacagaatac ctactgtgtg ccagacactg ggctaggtga 1200tggggatatg gagagaaaaa
gggatccctg cttacaagaa gcactgagtc tagcaagcca 1260tcatactgca aagaagtcac
tgttctcatg agagaagaac agaatcagga gcctccctag 1320cctgccctcc aggagaatga
cagcctacaa tttttgaatc cagaagctgc cccaattcag 1380cccccagcac ccctctctgc
agtccagagg ctgagccata gactgtggta ctcagagttc 1440tgatgtgccc tgtcttgccc
tcaggcctgc cggctccccc cagtatcatc aaggccatgg 1500gtgggagcca gccaggggaa
cttcagatca gctgggagga gccagctcca gaaatcagtg 1560atttcctgag gtacgaactc
cgctatggcc ccagagatcc caagaactcc actggtccca 1620cggtcataca gctgattgcc
acagaaacct gctgccctgc tctgcagagg cctcactcag 1680cctctgctct ggaccagtct
ccatgtgctc agcccacaat gccctggcaa gatggaccaa 1740agcagacctc cccaagtaga
gaagtatgct gaccttcttc tgccccacct cttatctcct 1800accttcaatc ttgccccagg
aaaggacaga ccatactttg gggattccag acctaggttc 1860gtccttggag agttagtata
ggctcagata tgagccacgc ctacttaggg gcttcctact 1920ttgggtcatt cccactgaca
aaagcaaagg ctttcaggcc tccaaattaa tggagatttc 1980gcaacaaaac cctgaacacc
acctgaaacc caccaactta gcccctggtc tgtgtgcata 2040tctatccagc aaggagctga
gctcctctcc acagagatgc tgtgcaaata taagggttgg 2100aggctctctc agctgacagg
cagacctaga ttgtgaagct gggattttcc tcccaaggct 2160tcagctctga cagcagaggg
tggaagctgc ctcatctcag gactccagcc tggcaactcc 2220tactggctgc agctgcgcag
cgaacctgat gggatctccc tcggtggctc ctggggatcc 2280tggtccctcc ctgtgactgt
ggacctgcct ggagatgcag gtgagtcaac aaaggaatag 2340ggagatgggg aggagataaa
agaatatctc tagggaagcc tgggctagat ctgaagctct 2400gggaaccatg gtccttcctg
atgatctcga acttgccact ggacaggaac tatgttcagg 2460gaaagaagag agaataggag
tcaatgttct aagttatatg tgtagaaatt atctgaaatc 2520tgaacaccct atacagtagg
ggcacacggg ccctgatggg acttacttct ttgactttag 2580tggcacttgg actgcaatgc
tttaccttgg acctgaagaa tgttacctgt caatggcagc 2640aacaggacca tgctagctcc
caaggcttct tctaccacag cagggcacgg tgctgcccca 2700gagacaggtg agagctgaac
tgctgattga ggttggtgtc atgggagtga gccacaatct 2760tgcagaaaaa aagaagagag
tgttcttggt cctcttcact ctccttcctt tgtctccaaa 2820ccatacagct ttcaatgctc
tcttatctat tctgtcatcc tccaatcgat attttatctt 2880ctcaacccct ctctgttccc
attgggaatg ctttggttta gtttagcctt aatcatgtca 2940ctgggaccat tgcaacatcc
tacagtctaa ttcacctcca atgtattccc catgctgcta 3000acagagtgat ctttgttaag
ctcaaactgt gcatgacctt tgtaaagctc taactttgca 3060tagtctcccc ttactcaaac
atgtactgca atttctcatt atcaaagcca taaaaaattt 3120agcctggcct tcaaagactt
ccaccaagca cctcattgat tcttcatcct ctccatatct 3180aaatctataa ccaagttgta
ttgattttac ctattaacta tctctagaat ctgcccactt 3240gtctatcact gccattatcc
tactacaacc catcattaat tctctcttgg gctactgaaa 3300agacatagta actgatcacc
ctgagtcttc caagtaattc ttcacatagg tgctgaaggg 3360atcttttcat tttgttttgt
tttgagacag tctggctctg ttgcccaggc tggaatgcaa 3420tagtgcaatc ttggctcact
gcaacctcca cctcccggga tcaagggatt ctcctgcctc 3480agcctcccaa ggagctggga
ttacaggcat gtgccaccat accccattaa ttatttttgt 3540atttagtaga gagggggctt
caccatgttg gtcaggctgg tctcgaactc ctgacctcag 3600gtgatccacc tgccttggcc
tcccaaagtg ctgggattac aggtgtgagc caccgcacct 3660agcctgaagg gaccttttaa
aagtgcaaaa atgaatgtaa cactccctgc ttaaaaatct 3720tcaatagctt cccactagtc
ttaggataaa gaaaaaaacc tctaccatgg acttgaaaag 3780ttctgagact cagcccctac
gtacttcttc agcttcatct tgtgctatgc tgccctttga 3840tccccatgct ccagcacagg
gcttctgtgg tcccctcata tctggcatat tcccttctgc 3900ttctaggtct ttacactgct
gtttacccag ccctactgcc tttacttaac ttctacttat 3960cctccaaatc tcaactcaag
cgtcactttc ttagggaccc tcccctggcc ttctttatta 4020agtccaatag cactaatata
cattcttgtt gtaccatgta ccgcttcttc ttcttctttt 4080tttttttctt ttttttttct
ttttgagaca gagtctcact ctgtcgccca ggctggaggg 4140cagtggtgcc atctcggctc
accgcaagcc ccgcctcccg ggttcatgcc attctcctgc 4200ctcagcctcc caagtagctg
ggactacagg tgcccgccac cacgcctggc taattttttg 4260tatttttagt agagatgggg
tttcactgta agtgttagcc aggatagtct cgatctgacc 4320tcgtgatcca cccacctcgg
cctcccaaag tgccgggatt acaggcgtga gccaccatgc 4380ctggccgtac ctctccttct
taagtactta tcatagtcat actttcatat ttatagttta 4440tatgattatt tggttgataa
taaaaatctg gccaggccca gtggctcaca cctgtaatcc 4500cagcactttg ggagactaag
gtgagaagat cacttgaggc caggagtttg agaccagcct 4560agacaacata gtgagacttc
gtctctacaa aatttcttta attagccagg catggtggca 4620cctgtattcc tagctacttg
ggaggctaag gtgggaggat ggcatgagcc taggagtttg 4680aggttacagt gagctatgat
tgcaccactg cactccagcc tgggcaacag atcaagactt 4740tgtctcaaaa aaaacaaatc
tctcagaact ccagttgaga aaggctgatc ttgaccacat 4800atgatccatg agggcaagat
caatgggttt ttattcacca atatattctc acctaccaat 4860agtaggtgcc tggtaaaaaa
ttgttgaaca ctattaacta tttaaatgta ttcttccagt 4920ttttttctat gtatttacat
acatctctat acaacattta aattttatta tttttgagat 4980agggtcttgc tctgttgtcc
aggctggagt gcagtggcat gattatggct cactgcagcc 5040tcgacctccc agactcaaac
gatcctccca cctgagcctc ctgattagct aggactacag 5100gcattttctt tctttctttc
tttctttctt tttttttttt tttaagtaga gacaaggtct 5160ccctatgttg cccagactgg
tctcaaactc ctgagctcaa gcaatcctcc catctcagcc 5220cctctaccac gcccagccta
acatgtaata tttttttttt ttttgagatg gagtcttgct 5280ctgttgccca ggctggagtg
cagtggtgtg atctcagctc actgcaacct ccgcctccag 5340ggttcaatcg attctcctgc
ctcagccccc cgagtagctg ggattataga tgtgcgacac 5400catgcccagc taattttttg
tatttttagt agagacgagg tttcatcatg ttagccaggc 5460tggtctcgaa ctcttgacct
caagtgatcc acccacctca gcctcccaaa gtgctgggat 5520tacaggtatg agccaccaca
cccagcctaa tatttaattt ttaaatataa attggattac 5580attacatata tggtttgttg
actcaccttt ttgcttaaaa acatgtctca gagatcatta 5640caaaaagatg taactcattc
tttttaataa ctgcatacat atccatagga ttgagatgcc 5700tgagtggact aaagggtagc
aaaactgaag tcatcatttc ctctatcaaa acttgctttt 5760cctgctgggc acagtggctc
acacctgtaa tcccagcact ttgggaggcc gaggtgggtg 5820gatcacctga ggtcagcagt
tggaaaccag cctggccaac atggtgaaac ctcatcatta 5880ctaaaaatac aaaaattagt
cgggtgtggt ggcacgcgcc tgtagtccca gcttcttggg 5940aggctgaggc aggagaaatg
cttgaacccg ggaagcggag gttgcagtga gctgaaatcg 6000tgcccctgca ctccagcctg
ggcaacagag agaagactct gtctcaaaaa aaaagaaaaa 6060aaaaacttgc tttttcttta
ttgtctccga tcctaccatg aattcagttt tcctggactg 6120aaaaatagaa atcatcctgg
acttctccca ttccaatacc ctccaggcct aaccagaaat 6180agtcttgtca tttttacctt
ttcaatatct cttcaatcat ctctttccct gtctctcact 6240gctgctaccc tattttcaca
tcctcatcac tttgcacatg aaaaactaca agaatgtcat 6300aatggatttc tctgcttcta
gtcggccctc acaaatcctt tctacagact gtagttagaa 6360tgatcttcct aaagtacaaa
ggtagctatg gcacttccct gcttaaaatc cttaaatgtc 6420tacataacta ccacaaggtt
agtagtaatt caagttcaag ctccccagaa aggccataag 6480gccatccatg acatggtctg
cagtctcaca tttaccacct accaccaggc cctttatgcg 6540aaaaccatct gcaccactta
gaatttcccc caaagcacca cactctctta tctatgcaca 6600accatgtgcc tgggatgcct
gtttgtccct tttgcctatc ctatttttag ttcaaaactc 6660agtctaaaca tcgccgtatc
caggaagcat tccctgaccc tcccagtctg ggttggatgc 6720tcccctttga tgctcccaag
ccagtctatg cacatcacag aaaaatatca tgtttgtttt 6780tctgtctttc ccactgaaat
tagagctctt tgaaccttat tcctctatgc actcataggg 6840cctggcacag taccaattgg
cacatagtat caattatttg ttgattaaat gggtaaacat 6900acccatttta gtgacggtga
gccacttagg ggttataatc aagagggaga catgattcaa 6960ttgttcaata aagaattatt
gagagtgact ttttgcaagg tactggggat aaatagtgca 7020acaaataaaa tggaaaaggg
gccaggctcg gtggctcaca cctgtaatcc cagcactttg 7080ggaggccaag gtgggcagat
cacttgaggt caggagttcg agaccagcct ggccaacatg 7140gcgaaacgcc atctctacta
aaaatacaga aattagtcag gtgtggtggt gggtgcctgt 7200aatcccagct actcaggagg
ctgaggcagg agaatcgctt ggacccaaga ggcagaggct 7260gcagtgagct gagatcgtac
cattgcactc cagcctgggc aacaaagcaa gactgtctca 7320aaacattttt aaaaataaat
aaagtggaaa gggttccagc attgttgggg cttacattag 7380tagaggggag gggaaaagga
gggggagaaa agtaagtaaa gaaataaagg aacaaagtta 7440taatagagac taaagggggg
cgtgtggtgg gtggggggtg ggtgttgcta atttagactg 7500agtggccagg aaaagcctca
ccagggaggt gacagataag ccgagatcta aatggcaaga 7560aggaatgagt cacatgaaga
cctacagtca gagcaatcca gggcaaaggc aaagtgcaaa 7620gatagcacat ttggcatatc
tatggcacag aaagaaggcc tgtgcggatg aagggtgata 7680aactggcatg agaatcataa
gagatgagaa tggcaaggca aggagaaacc aaatcacaga 7740gtcctgtagg cctggtaagg
ggtttgggtt ttattccaag tgggatgaag agccactgaa 7800ggattttaag cagtaaacaa
tgacaatttg acttacattt ttaaaagata tgtttctctg 7860tgaataaata aataagagta
gaagcagaat caccagtcag aaatttgcct taatccaagc 7920aaggaatgat agtggcttca
tctaacatag cagtggtaaa gatcaaaatc aatagtttgt 7980gacattatat tctggacatt
atcacatcaa catttttgga aacaaattct ggtagctgtg 8040tggagaacaa cttgaaggta
gtggcaaaaa cagaagcaga aaagccagtt aggagactat 8100tgtcataatc taatagcaaa
ataacacata ggggagagta ggaggaatga cgtatgagaa 8160cacgttaaaa atagaggata
tttttctcca gaaagatgag ggttctttaa tctttgaaac 8220aatcctgtga ggttggtatc
attaacccat tttacaaata gaaggaaact ggagcagaga 8280taaaccaagt aatttgccca
aagttacaca aaggtaagcc aagacctcaa ctcttggtga 8340aaacccatgc tgttttcaca
tatcatgcca ggtctttcct caaagggaag aggccagaca 8400acaaagctga cttcagaaaa
catcatggca aaatagcaaa aacaaacgaa caaatgaaca 8460aaggaaaaaa caaaaagaaa
acatcatggc ataaagacag agggaaagct ctggaggccc 8520ctggaaggaa ggagttaaat
gataatccct gcaggccatc gttcttgtag gatgggaagc 8580cttgggatta gtctctgggg
caggcctgat tcaatgactc tgtggggctg ggtcttaggt 8640accccatctg ggagaactgc
gaagaggaag agaaaacaaa tccaggacta cagaccccac 8700agttctctcg ctgccacttc
aagtcacgaa atgacagcat tattcacatc cttgtggagg 8760tgaccacagc cccgggtact
gttcacagct acctgggctc ccctttctgg atccaccagg 8820ctggtaagaa ctttcttcct
cattcttccc acatagttcc cacccccact gaatctgacc 8880ctgtgcccag gatccccaac
tctgaccctt ctgaccgatg gctctggtgg cacaatgcct 8940tgtgcacaga aggacttaag
ctgctccctg ctgacatccc tgtagtgcgc ctccccaccc 9000caaacttgca ctggagggag
atctccagtg ggcatctgga attggagtgg cagcacccat 9060cgtcctgggc agcccaagag
acctgttatc aactccgata cacaggagaa ggccatcagg 9120actggaaggt atggtcaagc
aacaaatgcc cacagacctc actacgcagg ggatccctgg 9180ggttggccat gcctgttagc
aggagtgaaa gtgtctatgt atccagtctc tgctagtata 9240tctatgttta tcagattcaa
ctggtatctt agtctctctt gggcatctga tatttctggc 9300tactcctact taacatttct
cttccctttg tctttgggat atcagtcttc cccgattttc 9360ctcctacctc tctgactgaa
ctttctcact ctcctctcct ggctcctcct ttccagcctt 9420ccacaaaatg ctgtgcttcc
tagagtctca tcctaggctc ttttctcctc tgataaaata 9480aatatgttct ccccaggtga
gtgctttaac tccatggttt caatgtccat acattaacaa 9540tcgcaatttt accattctaa
ctcccatatg gaaaggaatt tacaaaccac aggcaaatta 9600ccaaaatgtt tgaagtctgt
ttcctcattg gtgaaatgag gatgaagcta tctaccttat 9660ggagttatag taaagattaa
atactatatc taaataccta gcatactgcc tggcataagg 9720aaggtgctca atatacatta
cttaaatatt agtttgtcta cttttattct catttgccac 9780acatatatac aactatgtac
aacatcttat ggttctacca aaacttcctc cccctggaca 9840tttcagactc agtctatcca
gaatggaact cctcttcctc ctgaagcttt acttttttat 9900tgtgataaaa cttacataca
acaaagtgta caaattttac atatatagtc tgtacttgtg 9960tatacatcca cataaccata
accaggatca agatataaat tatttccagc acctcagaag 10020ctcccaatgc tccgacacat
cccccgccac caaaggtaat caccatcctg acattaccat 10080tgattcattt ggactgttgt
tgaactctat aaaatggaac cctaaagtat atcttcctca 10140aacttacttc tcttctgtgt
cctgtctctg acaatggcac cgctacttac ccagtaccca 10200agcctagaag cacccttgac
tcttcttgct cttcccttat cccttcccct tactcatcaa 10260ctaagttgat ggcaataacg
tactaatagt cctcaaattc ctaccaggat tgccttagac 10320tcatctgtga ccatccagcc
gtgtcatcca tgcttttagc acactaaact actctgtggc 10380acaaaaccaa gcattaaatg
cttctctgga cttccgtggt gccttgcact aattaattgt 10440tgtgattatt tacctgtttg
gatgtctttc tcattagata tgtaagagac ggtgttttat 10500tgctttctcc ccagtgccta
acccaatgtt tggagtatca cacagttcat aaatgtttgc 10560tgccttcctg cttgtacaca
tgatgcttgt accccagcgc ctaacgcaaa tctggcatcc 10620tctgcagcat gagtattatt
tgtggcatgg tctgtgtggc tctgaatata tctgtttctg 10680ggggtgtcca tcgcccgacc
tggagttgtg agaacacccg gtagggtgtg cgtgtaccgg 10740gatccctgcc gagggtgtac
ctgggtgttg gtgttaggat acgtagctct ctgaggtgag 10800gtctgtgtct caggaggtgg
gcctggcacg tttctctcgg gcagagcgtg atcccgttag 10860ggagaggctc tcggttaggg
cgctctatcc tgttgctggg aagcgtgttt tctgccggtg 10920gggctctttg tgggaatctc
cgaccgcctg gggattcgga gctgcaggat ttgggtcaaa 10980cagacgctgg gctatcgaag
ccccgacgcc gggccaccgc acgcttcttt gctcaggtgc 11040tggagccgcc tctcggggcc
cgaggaggga ccctggagct gcgcccgcga tctcgctacc 11100gtttacagct gcgcgccagg
ctcaacggcc ccacctacca aggtccctgg agctcgtggt 11160cggacccaac tagggtggag
accgccaccg agaccggtga ggcaagcccc ggccgcacca 11220aagccgcaca gcgcctgcgc
cagggactgg gcgccgggtg cgagtggggc ggggctcgga 11280gaggggcgag gcgcggggcg
cggagagggg cggggccctg accttgcggg ccgacggctg 11340cgcaggtgcc cgcagtgccc
aggggcggcg aggggcgggg ccagagtagg ggctggctgg 11400atgagggcgg ggctccggcc
cgggtgggcc gaagtctgac cctttttgtc tcctagcctg 11460gatctccttg gtgaccgctc
tgcatctagt gctgggcctc agcgccgtcc tgggcctgct 11520gctgctgagg tggcagtttc
ctgcacacta caggtaccgc ccccgccagg caggagactg 11580gcggtggacc aggtggagcc
gaaggcctgt aaacaggcat tcttggttcg ctctgtgacc 11640ccagatctcc gtccaccgcc
cgtgcgcacc tacggcttcg ccacttcctg cacgtcacct 11700ctgggactcg ccgcggctcc
ttacactcta acacgcccac tataccgccc acctcgaaca 11760gccccgcctc ctgctgctca
cctcggcgac taggccaccg tccacccttc agccaaactg 11820cccactccac ccccatccaa
tctgccgtca ggtcccacct cctaaaccta gtccaaacaa 11880tggccccctt tctctagccc
tacagacacg acctgactca ctgaaacaga acctcttgcc 11940cctccgatct agcctcacac
agccaccaga ataatctttc taaaatgcgc acatgaacct 12000atcaattccc tccttaaatc
ctttcaatag ctcccaggat atagtccagg ctccctatga 12060tgacaagcga ggctctgcaa
aatcggcccc tgccagcaag cacttcagcc tgttctaccc 12120tgtgcatcag cctttccaaa
ctggttttct ccacaagtca ggttttactt ctcagtgcct 12180ttgcacataa cgtccgctct
gcctgaaata gcctccctgt ctcactaaac ccattcatct 12240gtaaataact ttcttcacca
actcttaaga aacctttcct gaccctcccc cttttggccg 12300ctgctctgtg ctccaataca
gtaccagtag tgttttactg tgtttatttc tttatatatc 12360ttccctatta taccttactt
ggtcatcttt aaatccttag cacagtgcct gccaaaaagc 12420aggcccttaa ataaatgtta
ttaatgagtg actcatttat gtgggaagac gaaggctgag 12480gagaaatgcc attggaggct
ataaacatga agggtagaat gcatcccacc tccatccttc 12540atctgctgct tctttaagac
ttagctcaga agtcatctcc tccagatggt gtcttctgat 12600ggtcctgggc tggttcaggt
gccactctca tgggctacca tctccctctg aacatacctc 12660tctttgaact tttaatctgc
ccatacgtat gagcagactg aaaggtagcc tccatgcagg 12720tagccagatc caacaaaaaa
gttggagaag taggaggagg tggtctgctg agccaggcat 12780actcagtttc ttttccccaa
tttaccaggt aagtcacacc ttctcccctg gagagatatg 12840agtgaggtca ctgaagcggc
ctgaaatgtt ctactgacgt ccctccacat ggaaatatga 12900agctaaagaa tccaggttct
ggccgggtgc ggtggctcac gcctgtaatc ccagcacttt 12960gggaggccga ggtgggcaga
tcacaaggtc aggagatcaa gaccatcctg gctaacacag 13020tgaaacccca tctctactaa
aaatacaaaa aaaattagcc aggcatggtg gtgggcgcct 13080gtagtcccag ctactcagga
ggctgaggca ggagaatggt gtgaacctga gaggcggagc 13140ttgcagtgag ccaagaccgc
gccactgcac tccagcctgg gccacagagg gagactccat 13200ctcaaaaaca aaacaaaaca
aaacaaaaca aaacaaaaca aaacaacaaa aaaatggagg 13260cccctccaat acatcttaat
ccatattctt cccagataga ctaccctctc cagtaactta 13320ctaataagct ccactgattt
tcttcattca ttcattcagc taatttactg agcacctact 13380atgggtcaga cactattcta
caccctagaa atacaggagt gaataaatag acaaactctc 13440ttttctcggg gaccatatgt
tctagtgggg tgagacagac aaaaagaaat atacataaca 13500atgtaataaa tgtacaacaa
gtcaaatact ataaggaaaa atgaagtaca gcaggagata 13560gcctgtcatg gggaaaggaa
gcagcactac agtggtcccc tcttatccac agtttcactt 13620tttgtggttt cagttacacg
cagtcaatta aggtctgaaa aaaattacat ggaaaattcc 13680agaaataaac aattcatgta
ttttaaattg taagtagcac gatgaaatca cttgccatgc 13740cgctctgtcc cacccgggat
gtaaatcatc cctttgtcca gcatctccac gctgtatatg 13800ctccctgccc catagtcact
tagcagccat cttgcttatc agattgactc gttgaggtat 13860tgcagagctg tgttcaagta
accctcattt tagttaataa tggccccaaa gtacaagagt 13920agtgatgttg gcatattgtt
ctaattgttc tattttatta gtagtcatta ttaatctctt 13980actgtgccta atttataaac
tttattgtag gtatgtacgt atagaaaaaa catctgctgg 14040gagtcttgaa acatatcccc
tgcagataaa gagggactac tgtgtttcag gcaaggtagt 14100cagggatgac atttgaacag
aggcctacaa tgaggtgagg gaatgaatcc agtgttccag 14160acagaacaaa cattggagtg
tttgaggaaa ctgcagcacc ctttgttgaa cctgcccacc 14220actgacttcc ctcccctacc
tgaggttttc ttcttactct actcccctgc ccaactttat 14280tgccttgacc atgctcttat
atctccaagc cttactcccc ggcctcactg ctcccccacc 14340ccaactgctg tcctcctccc
tgccaatcca ctgccatggc tcagtctgct tctcttcctt 14400ctcccccagg agactgaggc
atgccctgtg gccctcactt ccagacctgc accgggtcct 14460aggccagtac cttagggaca
ctgcagccct gagcccggtg agtgtgcttc cctcccctgt 14520gcccaccacc aaccctgcct
ggtactggat ccttgcccca acaatacaac ttgttcaagg 14580tccttgccct accagtgtgc
catccccagg cactacccca gcactacccc agcccttctc 14640cttcctgtac agtccagccc
ctcctcccac aggatctgct ttaatccagc gcctctcctc 14700atctctccca gcccaaggcc
acagtctcag atacctgtga agaagtggaa cccagcctcc 14760ttgaaatcct ccccaagtcc
tcagagagga ctcctttgcc cctgtgttcc tcccaggccc 14820agatggacta ccgaagattg
cagccttctt gcctggggac catgcccctg tctgtgtgcc 14880cacccatggc tgagtcaggg
tcctgctgta ccacccacat tgccaaccat tcctacctac 14940cactaagcta ttggcagcag
ccttga 14966580968DNAArtificial
sequencesynthetic sequence 5cggcagacac gcacgcaccc gggcgccgaa gggaaagccg
cgtctcgccc tcccgccccg 60ccgtcggtcc tgtctcagtc cctcagcaga gcgggaaagc
ggaggccgga gccgtgacct 120ctgaccccgt ggttatgcgg agccgccgca ttccttagcg
atcgcggggc agccgccgct 180gccgccgtgg gcgactgacg cagcgcgggc gcgtggagcc
gccgccgccc ctcccccacc 240gccgctctcg cgccagccgg tccccgcgtg cccgcccctt
ctccccggcc gcacccgaga 300cctcgcgcgc cgccgctgcc acgcgccccc cccaccgccg
ccgccgcccc agccccgcgc 360caccgcccca gcccgcccag cccggaggtc ccgcgtggag
ctgccgccgc cgccggggag 420aaggatgaag gacaaacaga agaagaagaa ggagcgcacg
tgggccgagg ccgcgcgcct 480ggtgaggcgg acagccgagg ggggctccgt ggggcccggg
gtgggggggg ctcgccgcgc 540acccccccac tgggggggga ggggcaaggc cctgcccacc
gcgggagggg gcggggccat 600cttcctttaa gaacgggaca gccccgcaag gcgaggggtg
gggagcgctc cgccgggatg 660ggatgtggcg cctttttccg ctcgccctcg cgcccccccc
gccccgcgca gctaaattcc 720ggcggagggg cgagctggca ggccggctcc tcccactctg
ggcagcgggg tcccgcgtcc 780cctcccccac tatttggcag cgtctggggg tctggggcag
cttcgttcat tcacccgggg 840gagttgggtt tccgggaagg gtcggaagct cctccctcgc
ttcctggtgg gtaatggggt 900ggtgcctttg actccggggg tggaaaagcg accccacatt
caaggacgcc aatggcatgt 960tgagctttcc caatctaaac caggtgcgtg gagggaagca
agtgcttact cccagcttga 1020accctgagca gcggttctct aactttagtg tcctgtgggc
gacacctggg aggcggttag 1080gaacgctact cctagggccc ttcgtaagac ctgctgagcc
tcagggtctg ggatagagcc 1140tgggaatctg cgctttcacc agcttcccag gtgattcaaa
cgcagtggct cacggacccc 1200actttgagaa acgcagactg ggctgtttgc cttcagaagc
tggactggaa attggtattt 1260tgaggagaac tgaatccact ttgcaaagaa tgtatgttgg
acaaagacaa agtatctctg 1320ttgggagacg ttgttcactg aggatttagc aagggagagc
gtaacttgag tgtttgaagc 1380cgtctcgttc aaccgatggg ggttgtgaat tttgtgttca
gagcgtcaga ggacttgcag 1440gtgaaatagc ttccttttgg attactccca caaagctcag
acactttgag acatattcgg 1500gtaattatct gctgatacca gtagtaacag gttatactaa
gatgtcagtt cctaagatct 1560gtcacacagc gaggttgtgg tgcggatagc ataagtgtct
cttgacactg tagtttatat 1620gtaatggttg taattcagtt ttaatgatga gtgaagctca
gacttaattt tctctcttat 1680tttgaagtga gttttctgct tcaaaggtgt tgtgcaaaaa
aaaaaaaaat agactgtatt 1740gggggggttg acacaaacct gaagtacacc tttttctttc
tcgaagtctg taaaagttac 1800agatttataa aaactgaagg aatttgggct acagaatttt
cattggtgct tgctatcctc 1860ttccctagtc atttgttgcc cagggaacaa aaatagcaat
tgtttgtatg ctgaagtttt 1920gtgcttcagt ttattttggc ctggcatgtg aagtttgaag
attttgaggt tccgaaatat 1980tttttttctg attgagtcaa aattggaagc ttgggctagt
tttcaggatc ttgtagaaat 2040ttcaggattt ctctaacggt tctgcacctg gaaacaaata
taggcctgat ggggagtggg 2100agagagctct cgttctcctc ctcgacaatg agttttgtgt
gttcattgac attctccttg 2160gcgttcctgt tatgcgggtg tttatgaccc tgggcaccca
aggaaatttg cttgccagag 2220ttttacttgt tagaggtagg tgaaagtact tttaagtctt
gtgttattta tgtcttgaca 2280gaattatgaa atctgtttgt ctcaaagttc tgttggctct
tactagttga ctttaggaat 2340ttggggtcca ctgttaagtc tctttagatt ctcgaattta
ccgtggtctg aacttcaaca 2400tcgaggttgc tatttctgtt ttatcattga ctcaacttca
agccaggtta tcagggtaag 2460ttattcctct ttttcttcta aggctcttca ttaaaaatag
taatatgaat aggaattact 2520ttgtttgttt gtttttcgtt tgtttgccac cacacccggc
taatttttta tttttagtaa 2580agatggggtt tttccatgct ggtcaggctg gtctcgaact
cgtgacctta ggttatccgc 2640ccaccttggc ctcccaaagt gctgggatta caggcgtgag
ccaccgcgcc cagcctatga 2700gtaggaatta ctttgtggtg ctgttataca tgtgaaaaag
gatttgcgag actttgggag 2760tctgaggtgg aataatcact tgaggctagg aattcgagat
gagcctgggc aacatagacc 2820cggtctctac aacaacagca acaaaatgag ctgggcatgg
tggtacacac ctgtggtcct 2880agctactcag gaggctgagg atagcttagg ccgaggagtt
ggaggctgca gtgcccaatg 2940attgattgta ccactgcact ccagcctggg tgatagaggg
agaccctgac tctaaaaaaa 3000taatgaggct gggcgctgtg gctcacgcct gtaatcccag
cactttggga cgccgaggtg 3060ggtggatcac agggtcagga gttctagacc agcttggcca
acaaggtaaa acccagtctc 3120tactaaaaat acaaaaatta gccgggtgtg gtggtgcacg
cctgtaatcc cagctactga 3180gggggctgag acaggagaat cacttgaact tgggaggtgg
aggttgcaga gagccaaggc 3240catgccactg tccagcctgg gtgacagagc aagactcgtc
tcaaaaaaaa aaaaaaaaga 3300aaaaaagaaa aaggacttgt tgagaatgtg atatgcaatt
tgagtatctt gtgtgtgttt 3360tttgttttag aattttccat ttctttgaat gggactggat
ggtaggtgag ggggaacttt 3420ttaagagtcc caggccgggc acggtggctc acgcctgtaa
tcccagctct ttgggaggcc 3480gaggcagacg gatcacctga ggccagaagt tcgagaccag
cctggccaac atggtgaaac 3540cccgtctcta ctaaaaatac aaaaattagc caggcatggt
gatggtgcat gcctgtaacc 3600tcagctactc gggaggctga ggcaggagaa tcacttgaac
tcgggaggtg gaggttgcag 3660tgaacccaga tcacaccact gcactccagc ggcgacagtg
agactctgtc tcaaaaacaa 3720aacaaaagaa aaaaccagtc ctcttaatgt ttaaaaaaag
ttgctgtaac actgtactgg 3780agaatttgtg agagcgtaca ctggactgag agaaacttga
ctaggaggga acgtaggaca 3840gttgattaga acacctgaac acttctcttt gggcaggtga
atttggagtg cttgcaatgg 3900caattgtatg cacttccatg ggaacgcttt cagattgctc
ctgaccccac tcagattggt 3960gactagagtg ttactgggaa tccttttaaa aattgttttt
gtaggctgtg cgcggtggct 4020cacgcctgta atcccagcac tttgggaggc cgaggcgggc
ggatcacgag gtcaggagat 4080cgagaccatc ctggctaaca cggtgaaacc ccatctctac
taaaaataca aaaaattagc 4140caggcgtggt ggcgagtgcc tgtagtccca gctactcggg
aggctgaggc cggagaatgg 4200cgtgaacgcg ggaggcggag cttgcagtga gccgagatcg
agctactgca ctccatccag 4260cctgggcgac agagcaagac tctgtctcaa aaacaaacaa
acaaaacaac aacaacaaaa 4320aaacctttcg tagaggaaag aagattctta agaatttcag
tatagtgtac cccaggagat 4380tgatttttgc agatgttaat tatgctgttg aaaaatagtc
tttctttcac acattttgta 4440gtattgtctt ttctaggtgt aagaagtaga ccttatgtgg
ttgagtggat ataaatcctc 4500caacttgtta taaacagttt gtttgggaga aatagccaag
gggatttccc tttaaatcga 4560ggacgctaaa tggattctcc ctggcttcga gaaactcttt
gttgtatgct ttatctttta 4620ctttgattca tgactgacca gttcttacat caaacatttt
tttccccttt gaagtaagag 4680aagagatact taaaaaaaaa aatgtagtct agaaagagac
taggaataga acactgctga 4740cttgttctta taccaagagc tggaggcata aacagtttta
ataaaaaaga atactttgta 4800tcttttgatg taacttccct ttagagattc tgtttcccct
gtcttaaatt ctcaggctat 4860ttctgattgc tgtttaaata attggtagtt actatttgag
tcatgcttct taaaaaaaaa 4920agatataaaa attcgccagc tcagctttca tttaattagt
atcaaagaaa tgttatctgt 4980ggcagtgaac attagtagct tgttccaggg tttattgtag
gtttgttcaa gtcagtactg 5040cccatcttgg cacttaggtt cttggaatac agaggtggat
aaggtttgcc cctcagggct 5100tatggtcttc tggggatgaa gaaggtccag acgcaggaac
agaattttac tacagtcatg 5160atacgtgtta tcatagttgt ataaatcata aacagatatc
ccagttgctg cctcttgtct 5220agtcatagtt tctcctttca ctctcaactg tcctggtttg
gaagataatt gtatgtgtta 5280tgaaacaatg ggaacattga aaagagacat ttacctctgc
ctggcagaga tcagggaagg 5340cttcctggag gaaggtgctt tctgagctga atcttgaagg
gtaactagga gttaggccaa 5400tcacagaggg cataagcagg agctggtgac aacacatagc
aggagagaaa gagtcagagt 5460gggtgagagg gagtgtgtgt atttgcaacg tgtgggaatt
aggtatatct acaaattatt 5520ggaacataaa gtttgtagag tgtcactgtg gatgggtaga
gaggcagaga ccagattgtg 5580agggttccat atgccaggcc agtgagcacc tactctgtgc
cagacattgt aggcattact 5640tacattgtct ctaatctgtc caacaactcg agaggaagac
atcagtatcc ttcaaaagag 5700aacctaggtt caggttgggt tgtaattgcc ccagtttaga
atgtaaaaat ttgaatctaa 5760ctctagatcc tgttctttac cggtgggcca gtggactttg
gaagcttcag cttttgcagt 5820atgtgattaa ggagctgttg aaggatttta tttgctttct
attattatta ttactatttt 5880ttgagacagg gtctcactct gtcaccctgg ctgaagtgca
gtggtgccat cacagctcac 5940tgcagcttcc acttcctggg ctcagatgat tctcccacct
cagcctcctg tgtagctggg 6000attacgggca tgagccacca tgcccatcta gttttttgta
tttttttgta gagacagggt 6060ttcaccatgt cgcccaggct ggttttgaac tcctaggctc
aagcaatctg cccaccttgg 6120cctcccaaag tgctgggatt acaggtgtga cccactttac
ccagccatat atatttttta 6180aattctttaa agagatgagg tttcactgtg ttacccaggc
tggagtgcag tggctataca 6240caggcacgat catagtgcac tagagcctgg agctcctgag
cgcagcaagt gaccctcctg 6300cctcagtctc agctgagact ataggtgtgc accaccgtgc
ctggcctgtt gaaggatttt 6360agagctgaaa gtgatgaggg caggtttgct ttgctgggtt
gacctcagtc tataacatgt 6420aagttctacc agagcaggga tttggtcttg tttactgtga
atccctagaa ttgtgtctgg 6480cacaaggtac gtgttccatg tgtttgttga atgaaggatg
acaacagagt cagaatggat 6540ttgaggaaag caggactgga tggagggata aatattaaga
ggctgttgtg ttgggtcagg 6600taagagactg gttttgggac ttggcggaca gatgagcgag
aaagatgaca cctgcgtttc 6660tgaattaggt gattatacag gctgtcaatc aaggtaggga
atacaggaag aagagtgggt 6720ctggagaaga ggtgaattag agttgccaat tagatgaatt
aagagtagag ctgaattaga 6780gtagataatg aaggggtata gtcagtacac aactgaatat
ttgaatctga aatttggggg 6840agaagtcaga gctagaggta gagattaggt agttatcaga
atttaggtag tagctgaaac 6900tgagatgata atgttaccca tggagaatgg aaaatctgaa
aagagaagca aagaatagga 6960ccatgggaaa taggggtttt attttagtac cttctccaaa
ccttgacttt ggtgctgagg 7020tcttatgttc ttccatagag agtaccttcc gcagcagacc
tatcagacga gatcgggcac 7080attcagggtg gtatggctgt agacagcagc atcgtatcag
acttctttat gttttgcttg 7140tgacagcagt acttggctat ggcagttaaa tggactgtaa
gatgttagct tgatttggag 7200taccctgagt agctgcacag gtagacaaag tacaaagata
ttgacagctt ttttcttcct 7260ttagaagaat aacatatcta aaacaactct taaagcaaga
gagctgcagt tgcacactaa 7320gaaaatactg caatactgcc atgacttggt tataggtgat
gctaacataa atgggatatt 7380ctgtttctca ttgcaccagt catgcagaat catagcatca
tgtgccagat ggcagaacgt 7440actgtggcag ttaacaccac aaattaacaa cacagtggca
gaaagcaccg tttaaaaata 7500tgggtacttg gccaggcgtg gtggctcact tctataatcc
cagcacttta ggaggctgag 7560gcgggcagat cacctgaggt caggagttcg agactagctc
tagtctctac taaaatacaa 7620aaattagtgt gtgtgtgtat atatatatac taatcaaact
tccttgggaa agaaaatgtg 7680aatgcatttc tgtgtcatac atttcttgtg cagcactata
tattctgtgg tttagcagta 7740ttaacagcat caagctgaac agtaaccagt gttgctaagg
tctcgcatac tataccatgt 7800atgctgagaa gatatgcatc cttagaattg agaattagaa
catttcagtt aattgcagta 7860acttttcagt aactagatat atgtgtaatt tgatttctga
agtaatttta actgtggaaa 7920aactaagttg tcaccagcgg tacctcatag cataacttta
gcccatgata tatggatgga 7980tggatataaa tggaaattgc acactgaaat taggacgttt
atatttcttc aggtattaga 8040aaactactcg gatgctccaa tgacaccaaa acagattctg
caggtcatag aggcagaagg 8100actaaaggaa atgaggtttg tattgttctt gttgcttaac
atgagggttt cataggatat 8160gtgtctttct gtagttgtag tgatatgagt aagtacacct
gtgtatgtat ttgtgcttct 8220gtgtctggta gtgagatgga actatccatt tcccaaattg
tgtgtcgtct cagtggaggg 8280tggcagtggg tgaacatcca tttgttttca tttagaggtg
cagtggcttt ccccatctcc 8340ttgttcttcc ttaaatcttg gcatagagct tgttttttgt
gtaaggagtc agggcacatt 8400ttctcttgtg ctgttttgga agtttcagac ctgatagcct
ctattgtgcc taacgctacc 8460cttttctcta tgccgtatca ctgaagttct ttcttttaga
ataaaagaac agtggtctca 8520tcaacataaa aaaccactga cttttttccc cttactaatt
gcagtcatat atgatgtgaa 8580tttactaaat tttgaggtga cctttatttt ccaaatttat
ggtgtagttt tcctggagaa 8640gtaacaagtt agaaacatag aatttgcagg cttgaaagcc
aggactatct ttcatctttc 8700tttttcctca tcctaacttc aaacttaaaa aaaaaaaaaa
aaaaagctgg gggtagtggc 8760ccatgcctgt aatcccagca ctttgggagg ccaaggcagg
cagatcactt aggtcaggag 8820ttcgagacca gcctggccaa catggcaaaa ccccgtctct
actaacaata caaagattag 8880ccggcatggt gacgcatgcc tgtagcctgt agttccagct
tgggaggcgg aggctggaga 8940atcgcttgaa ctcaggagac ggaggttgca gtgagccgag
attgcaccac tgcactccag 9000cctggacaac agaataagac tgcatctcaa aaaacaaaac
aaaacaaaaa acaaagaaag 9060tacttaaatg aggaaagagg agagcactac acagtccttg
cctgggactc agagcaaact 9120tcatgttttt gctagtcaaa cttagctgct ttaattgacc
ttttagggtc aaaaggcctt 9180cactttccag ttgtcagttc aaacgttctc aagttgatgt
tttgtgggga gggaagattg 9240agattgtcta catcacattt atttgacttg tacttatcca
ctgtgtagtg ttataattgt 9300gctttatttt tgtttttatg ggctatttcc catcatgctg
ctgtctgcac tgctgttgga 9360ccactttgcc tatagaaggt aaatgagtcc ctttgggaca
tatggaattg agaaccttaa 9420cttgtttctg cttcttgttc ttagaggaat tatgaagcag
tcatgatggc tcatgatgag 9480tgagcagctc tgtaatttgt agacagaggt ataatatgta
ggagtcacag aagagctgtg 9540ccagcatgct gttccccttg tagcagagat gctagcacac
ccacttgata ctccagattt 9600tgcatagggt ttcttttaga gattggttct tggtgaaaaa
ttttttagca tccagtgtgt 9660tccaaggcaa aataagtaat agttttttaa tggttttttt
agactcagaa tttattttta 9720acactgcata aattagggct tctagttctg aaaaatgcaa
agaggcttac ttaagctatt 9780tatatatttt ttaacatgct ggggagaggg aagagagggt
gcacaggtga ctcctagcac 9840taatatgcta gtgccaaact cagttaatat taataatggt
catttgttga tatttttggt 9900agcttttcta tttaaagatt cagtaagtag catcctttgc
actgaattgt cacgttttgt 9960aacctgctgt tgtggcaggg accatgaaac aacttagtat
gccattgttt cagtttattt 10020tttaagcatt actgggaact aaatccactt gacttacttt
ttgcatttag gtttaaataa 10080ttgttcctgg gtagatacag aataaaactc aatctcccca
cttccagcag agaaaaaaca 10140aatgaaatac tgttcttttt gtgtacttac tagaaaatgt
ttaactggaa aaaaagttct 10200gcttgtttta ttggcacagc accattgatt ctgtgattct
ttgtcatagt attctgtggc 10260agtttctgag tatgatatgt agattgaaat atagaggcta
ggaaactttt aatagtaaaa 10320ttttactaaa aatttattaa cttattaaaa tataacttga
aaaaattgtg aggtttttct 10380aaatttcttg gaaatttgat ttatattgtc aaaaagcact
gaagaagtgt tagttatgga 10440tttcgggtat cacataatgt ttattccaga gttttctgag
tgtgatttat gtgaatttca 10500tttggttatt cttttactat tttcacagtg aaattgtcat
gagatttttt cttctgtatt 10560tcttgcttag cttcttctca tttaagaatg agttggaggg
attaggtctt taagtaggca 10620gatggattgt ataaccctca tccattcttt tgtggtttta
cagtgggact tcccctctcg 10680catgcctcaa tgctatgcta cattccaatt caagaggagg
agaggggttg ttttataaac 10740tgcctggccg aatcagcctt ttcacgctca aggtaagtga
tatgaactct cttttggtgc 10800agtgattctt ggacttttaa tgtgcataaa aatcacctgg
taggtctgga ataggggcca 10860tgaatttgca tttctcatat gcagtcaggt gacactgatg
tttttctttt ttttagacat 10920agtctcgctg tgtcacccag gctggagtgc aatggggcga
gatctcggct cactgcaatc 10980tctgcctccc atgttcaagt gattctccca cctcaacctc
ccaagtagct gggactacag 11040gcacatgcca ccatgctcgg ctaatttttt tatttttttt
aatagagacg gggtttcacc 11100atgttggcca ggctggtctc gaaatcctga cctcaggtga
tccacctacc tcggcctccc 11160aaagtgctgg gattacaggc atgagccacc gcacctggcc
agatgctgtt ggttctaaat 11220ggcactttga ggtgttctaa tatgaatcag atattagaaa
ttatttagtc atagcagctc 11280ttgtttgtgt gttcatcttt tcttgtctat atctttgtag
attgtacaaa actgaagcat 11340aactatgggg ataattgcag atgtgccttt tttttttttt
tttttttttt attctgagat 11400ggagtctcac tctgttgccc aggctggagt gcagtggtgc
gatctcagct cattgcaccc 11460tccacctccc aggttcaagc aattcttctg cctcagcctc
ctgagtagct aagagtgcac 11520taccatgccc aggtaatttt tgtattttta gtagagacgg
ggtttcacca tgttggccag 11580gctcgtcttg aactcctgac cttgtgatcc gtccgcctta
gcctcccaaa gtgctgggat 11640tacaggcgtg agccactgca cctggccaca gatgtgcctt
aattaggatt ttgttgtagt 11700aatgatgtga aggataaatt actggtcagc taatgtaaga
cctactctat ggaaaataac 11760tgaaatgtga acatatttgt ggaaattaag tgacagtaat
tataaagtaa gagtacttaa 11820atcaggtaga gttcataata aagcttaaat agggccgaaa
tgaacaggct aattattttt 11880ccaccatttg tgatatatat ggtaatcatt tagaccgggg
gtctgcaaag tttttctgta 11940aaggaccaga aaatcaatgt ttttttgttt tgtggatcat
actgtctttg tcttaaccac 12000tcaggtctgc cattgtagta ggaaagcagc catacccaaa
tgaatgggca tggctgtgtt 12060ccaaaaaaaa aaaaaattta tttacaaatg tttgttttac
ttacgaaaac aggctgcagg 12120ccagatttga tttggggctg tactttgtcg acccctgatt
tagacataag atgacttgtc 12180gacattggag aaactgaaaa tttgatgctg accctttcgt
tcttccatag tgggttataa 12240attttagcag tcagtacaaa ctttttcctt taagttttgt
tttcttgatg gactgtattc 12300aaaataaata cctgaacaaa taccaactat ataacatgaa
gccataaaac ttggtcttta 12360tatataaata aagtttatct tggggtcaga tgtctgtgct
gttttctata tttttttata 12420tccaatagtt tggtcttttt cctttcagtt ttgtatgctt
ttcttgtaat cgagccttgg 12480aagagacaga gccactgagc ccaaaaccta gctttgtggt
cggctgtggt ggctcatgcc 12540tgtaatccca gcactttggg aggctaaggc gggaggattg
cttaaactca ggagtatgag 12600accttgtctc tattaaaaaa aaaaaaaaaa aaaaaaagcc
ttgcgtggtg gtgtgtgtgc 12660ttatagtctt agctactcag gaggctgaag caggagggta
gcttggagat ggaggctgca 12720gtgagctgtg atcacaccac tgctctccag cctgggccac
atagcaagac cctgtctcaa 12780aacaaaaact tagctttgta acctgggagg gatttaaccc
ttctttttgg tggaatatgc 12840atccctggca ttgagtcagt ccttaataaa tgatagcctt
tatgatgatc tgaggtttat 12900cattcttaat tgcctgttaa tggcattttt ctattaatat
tatctatttt ttgagatagg 12960gtcttgttct gtcacctggg ctggagtgca gtatcatagt
cacagctcac tgcagccttg 13020acctactagg ctcaagtgat cctcccacct cagccttctg
agtagctagg acttcaggcg 13080cataccacta tgcctggcta attttttgta ttttttgtgg
agaaggagtt ttgccatgtt 13140gcccaggctg gtctcgagct cctggggtca agcgatccac
tggctttggc ctcccaaact 13200gccaggatta cagacgtggg ccactgcacc tggcctatta
ttttttaatt taatattaat 13260ttatattttt agaaacaggg tctcacactg ttgtccacag
ctggagtgca gtagtataat 13320catagctcac cgtagccttg aactcctggg ctcaagcagt
agtcccacct cagcctcccg 13380agtagcgtac accatcaccc cagctaattt ttaaattttt
tcctagagat gaagtcttgc 13440tatgttggtt aaactggtct caaactcctg gcctcaagtg
atcttcccac cacagcttca 13500caaagcactg ggatggatta caggtgtgag caaccatacc
tggccctcta ttatctcata 13560tatagcttat tgttacatat gctgtaatta tatatagtta
taattattta atacatatat 13620gtttattaca aatatgcctg ttaatggtat attctgtttt
taaaaggaag gataattact 13680tttttctatg agtaccttaa gggcaggaac tgagttttat
ttgtgtttgt aatttggctc 13740tgggcagaat tcttggcata gtacgtgctt tatgtgtgaa
ctgaattata tttcttcatc 13800ttaattttac aggtgtgagc cactgcacca ggccccttca
tcttaatttt aatatatctt 13860tgaataaaca ccattgtatg aacctgctgt aagcttggga
gtggtctgtt agtctacagc 13920ttgtgtctga gatgtgctaa ttgaatattt gctcagtacc
tcatcttaac tgcctttggc 13980tttatgttgc ttatccttca tagtatcttg ttcattggcc
ttttacatcc ataggcatca 14040cttctctgat attcgttgtg ctcttttaat ggattaatgg
tttgcttggt tggttcctct 14100agttagactg taaactcctt gagagcagag tctgtatttt
attaattacc cacagtacta 14160ggtacatagt tgccttcaat aaatatatat ttaatgaacg
aatttagtga ataatggcta 14220catttttgta cttcgttatt atttatttat tttttttttc
tgagacagag tcttgctctg 14280taacccacgc tggagtgcag tggtgtgatc ttggctcact
gcaacctcca ccgcccaggc 14340tgaagtgatt ctcctgcctc agcctcccga gtagctagga
ctacaggcgt gcaccaccat 14400acctggccaa tttttgtatt tttagtagag atgggatttt
actatgttgg ccaggctggt 14460cttgaactct tgacctcgtg atccgtctgc ctcggcctcc
cagagtgctg ggattacagg 14520tgtgagccac cgcgcccagc cttcattatt cttttgacat
ttgatgataa atactgttta 14580tgattttctt tttctttttt tttttttggt agagacagtc
tcgctttgtt gcccaggctg 14640gtcttgaact tttggactca agcgatccac ccacctcagc
ctcccaaagt gttgggttta 14700catgcatgag ccacctcgtg tgtccttgtt cataattttg
atgggctggg cgcagtggct 14760cacgcctgta atcccagcac tttgggaggc cgaggtgggt
gaatcacttg aggtcaggag 14820ttcaagacca gcctggccaa catggcgaaa ccccgtctct
acgaaaaata caaaaattag 14880ccgggcgtgg ttgtgcacgc ctgtaatcct agctacccaa
gaggctgagg caggagaatc 14940actttaaccc gggagatgga ggttgcagtg agctgagatc
gtgccattgc actccagcct 15000gggcaacaag agtgaagctc catctcaaga acagttttga
tgaaattgtc cctagatttg 15060catctggcat ctagctcata tctcagagcc agaatgaagg
atgcttacct ctgggtttgg 15120taaattttag cttggttaat tatgtgtgtg ccttaatttt
tttgacctat tataaaagca 15180atatacgtaa atgcaacaga gaaaatgaaa gtaatccata
aaattctacc tgtggccagc 15240tgcgatggct catgcctgta atcccagcac tttgggaggt
tgcggtgggt ggatcacttg 15300aggtcaggag ttcgagacca gcctggccaa catggtgaaa
ccctgtctct actgaaaatg 15360cgaaaattag ctgggcatgg tggtgggtgc ctgtaattcc
aggtacttgg ggaggctgag 15420gctggagaat tgcttgaacc cgggaggcag aggttgcagt
gagccaagat tgcaccactg 15480cactctagcc tgggtgacag agactcttaa gaaaaagaaa
aaaaaattca gatacctgta 15540acctaaataa ttaatatttg aaaaaatttc atcattgctt
ctttcattca gttaatatat 15600tttgaaccac ttgccatggt gttatatata gacatgtctt
atatatgtgt atatatatgt 15660gtgtatttat ttattttttg agacagagtc tcgctttgtc
atccaggctg gagttcagtg 15720gtacaatcat ggctcactgc acccttgact tcctgggctc
aagcaatcct tccagcttcc 15780ctagtagctg ggactacagg cgcatgccac cacacccagc
taatttttgt agtttttgtt 15840gaggtgggaa ttcactagtc ttgaattcct gagctcaagc
aatcctccca tcttggcttc 15900ccaaagtgct gggattatag gcatgagcca ctgtgctcac
ccagtttttt atttttagat 15960acagggtctc gctctgtggc ttaaagctag atggtgcagt
ggcaccatca tagctcacta 16020caaccttgag cgcctgggct taaggaatct tcctgtcagc
ctccccagta gctgggacca 16080caggcatgca ccactgcacc taattaaaaa aaattttttt
tatagagatg gagggggtct 16140cattttgttc ctcaggctag tctcaaactc ctggcctcaa
gcaatcctct gcttcagcct 16200cccgaagtgc tgggattaca ggtgtgagcc acggtgcccg
gccccttatt ctttttgaag 16260gctgttttaa gaattccaga tttccagcca tgaatgtgtg
attactaact agtctcttgt 16320tatatgcctc atcaacacca cacttctccc agaagttgtg
caggcattta gtttattgtt 16380actcaggaat ggatgagaaa ggatatcaaa gatctgaacc
agctgattac catcttggtc 16440acttgagaac tcaggtctgt ccaataaaca ccctaatcca
aggtggtgtt aaatacatat 16500atatatattt ttactttacg tttatttatt ttgaaaaatt
tcaaacctat agaaaaattg 16560aggcagtacc atagtcttag tccattttcc attacttaga
atatccaaaa gtgagtaatt 16620tataaagaaa attaatttat ttcttacagc tatggaggcc
aaggtcgagg ggacatatct 16680ggtcagcgtt ttgccatgtt ggtcaggctg gtctcgaact
cctgacctca aggcctgcct 16740tggcctccca aagtgctggg attacaggca taagccaccg
tgcccagcca cctctgagca 16800ctttagatag tatgtcttaa gaacaaagac atagcccggc
gcagtggctc acgcctgtaa 16860tcccagcagt ttgggaggct gagtcgggcg gatcacctta
ggtcaggagt tcgcggcaaa 16920accccgttac tactaaaaat acaaaaaatt agctgggtgt
ggtggcgtgc acctgtaatc 16980ccagctactc gggaggctga ggctggagaa tcacttgaac
ccaggaggca gaggctgcag 17040tgagccgaga tggcaccact gcactgtagc ctgggtgaca
gagcaagact tggtctcaaa 17100aaaaaaaaag aaaaaaagaa caaagacatt ttcctatata
accacaatgc cgttatcaca 17160ctcaagaaac ttaacattga tatgattgtg tataatacat
agtccatatt caaatttttc 17220tctcatttca aaattattct ttgtggccta aaatcctgta
tccaatcatg atatttttga 17280acaatccaga ctagttgttg tatagaagta agtagtttgt
tttttttgtt ttgttttgtt 17340ttgttttttg agacagggcc tggctccgtt gcccaggctg
gagtgcagtg gcatgatcac 17400ggcttactgc aacctctgcc tcctgtgctc aagcaatctt
gtgcctcagc ttcctaaata 17460actggaatta gaggtgcgtg acaccacgcc tagctaattt
ttgtattttt aatagagatg 17520gggttttgtc atgttgccca ggctggtctt gaactcctgg
actcgaagca atcctcccac 17580ctcagcctcc caaagtgctg ggatttatag gtgtgagcca
ccaggcctgg cagttaagta 17640cattttttaa ggactaataa aaatgtagaa atcttcgtta
tttccggaat cctttatgtt 17700ttactgccag tactaatgta gtaatgccag acagtagtca
tgtctactgt tccaggttgt 17760ccaaaggatt cagcagcaaa ggatgaaagt ggtgggaagt
tttgcatagt ggtcgaccaa 17820gggctagttt ggtgagtgtc ttgcctatga taatggacag
gaagacacca gttattttat 17880tttattttta ttttatttta ttttatttta attttatttt
gtgttgtgtt gtgttatctt 17940tgagatggag tctcactgta tcacccaggc tggagtgcag
tggcgcaatc tcggctcact 18000gtaacctctg cctcccgggt tgaagtgatc ctcctgcctc
agcctcttga gtagctggga 18060ttatatgcgt gagccaccac acccgactaa ttttttgtat
ttttagtaga gacagggttt 18120taccatgttg gccaggctgg tcttgaactc cttacctcag
gtgatccacc caccgcagcc 18180ccccaaagtg ttgggattac aggcgtgagc caccacaccc
agctgacacc agttatttaa 18240ctcacatttc tctgttttcc ttttaaaggt agtagtgaca
cctttgaaat cttttggcat 18300tttctttgcc tgttctccct tatgtgttaa ggataagctt
acgtgcagaa tggcttgtta 18360agttttttct cctccgtact tggaaatctc atctggtggg
acattagggt cagaattttg 18420tatattatat attatatatc tatcatgata tatataatgt
attttatata ttatatatta 18480tataaatatc atgatagata tataatatat aattatatgt
tatatatttt atatttataa 18540aataaaaata aaaaattgca attattttca aatagtaaaa
ccacgtagat aaaatataat 18600tctggccagg cacgtggctc atgcctgtaa tcccagcact
ttgggaggct aaggtgggtg 18660gatcacctga ggtcaggtga tataatatac aacagatata
atatgtctat tatatattat 18720atataatgtt atatagatat ctatattata tataatatat
taatagatat attaatataa 18780tatatattat atattataca gatatctata aatatattat
atataatata ttatagatat 18840atctatgtat attatatcac ctgacgtcag gtgatccacc
caccttagcc tcgcaaagtg 18900ctgggattac aggcgtgagc cacgtgcctg gccagaatta
tattttatct acgtggtttt 18960actatttgaa aataattgca attttttatt ttattttttg
gttctggaaa catttgtgtg 19020gacttaccta tgattgtcag gtttactgat ttgctggaga
ttttttgggc atgacaaagg 19080gtttcttctt tgataaaagt ttttctgggt aatgtgatgg
tacaggttga gtatccttta 19140tctgaaatgc ttgagacatg aagtgttttg gatttgagaa
tttttagcat cttggaatat 19200ttaccacata catagtaagg taccttgagg atggggccca
agtctaaaca cagaattcat 19260ttgtgtttca tatttatctt atatgcatga aacaaagttg
tttgttttct tttttttttg 19320agacggagtc tcactctgtc gcccaggctg gagtgcaatg
gcatggtctt ggctcactgc 19380aacctccgcc tcccaggtcc aagcgattct cttacctcag
cctcctgcgt agctgggatt 19440acagacatga ggcaccatgc ccggcaaatt tttgtatttt
tagtagagat ggggtttcac 19500catgttggcc aggctggtct caaacccctg acctgaagtg
atctgcctgc ctcagcctcc 19560caaagtcctg ggattacagg tgtgaaccac cgcacctggc
cccaaaataa agttttgact 19620ctgtgtgtgt gtgtgtgtgt gtgtgtgtgt gttttggaga
cagagtctca ctctgtcgcc 19680caggctggag tgcagtggca tgatcacagc tcactgcaac
cttagcttcc tgggctcaaa 19740tgatcctccc actttagcct cccaggtagt tgggactaca
ggtgcgtgcc actgtggctg 19800agtaatttgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
gtgttttaat agagatgggg 19860ctttgccatg ttgcccagcc tggctcttga cctcttgggc
tcaagccatc tgcccacctt 19920gacctcccaa agtgctagga ttataggcgt gaaccaccat
gcccagcctt tgactgtgtt 19980ttgatggcaa cccatcacgt gaggtcaggt gtagaaattt
ccatttttgg cgtcaggttg 20040gcactccaaa ggtttcagat tgtggagctc cttggagttt
tggattaggg atgctcagcc 20100tgtacatttg acagtttatt tacagatgct tgcatcagtg
cttggagcta gtcctcagtg 20160gtgggatagg tgaaaattat ctctactttg agttcttgat
ttgaattctt ttttcttaag 20220cttttcctaa agtcatgtgt cagtgttgat tattgcccgg
ttagaggtag gatttgtatt 20280gtttttttac acttggaatt tcctgttgtc ataagatcac
tgtgaactcc cttgtagtgt 20340tgtacattct taggactttc atgctgaaat actatgcttt
tataaaatgg ttgttgtgtc 20400tttgctgagt ttaaataggg tccaggccag gcatggtggc
tcatgcttac cctgtctcaa 20460aaaaaaaaca ccctcaacta aatatagtta aataggccag
gctcggtggc tcatgcctgt 20520aatcccagca ctttgggagg cggaggcggg cggatcacct
gaggtcagga gttcgagacc 20580agcctggcta acacggcgaa gccctgtctc tattaaaaat
aaaaaaaaaa cctagccagg 20640tgtggtggtg aacgcctgta gtcccagcta ctcgggaggc
tgaggcagga gaatcacttg 20700aacccagaga cagagtgaga ctctgtctct cacacacaca
cacacacaga taaataaatt 20760gggttcataa atggtgattc cagcactcac tgtcaggtat
aacttcagtc tttttttttt 20820tttttttttt tttttttttt tttttttttt tgagacagag
tctccttctg tcacccaggc 20880tggagagcag tggtgtagtc tcagctcatt gcaacctcca
ccttctaggt tcaagcagtt 20940cttctgcctt agcctcccag gtagctggga ttacaggtgc
agaccaccac gcccaactaa 21000tttatttatt tattattatt attattatta ttttttagta
gagatggagt tttgccatgt 21060tggtcaggct gactttgaac tcctgacttc atgtgatcca
cctgccttgg cctcccaaag 21120tgctgggatt acaggtgtga gccactgtgt ccagccaaca
ttattcactt ttgttgttac 21180ataagatgtc acggccaggc atggtgggtc acgcctgtaa
tcccagcact ttgggaggct 21240gaggtgtgtg gatcacctga ggtcaggagt ttgagaccag
cctggccaac ctggtgaaac 21300cccgtctgta ctaaaaatat gaaaattagc tgggattaca
ggcgggcacc tgtaatccca 21360gctactaggg aggctgaggc aggagaatca cttgaacccg
ggaggcagag gttgcagtga 21420gctgagatcg tgccattgca ctccagcctg ggtgacagag
caagactgcg tctcaaaaaa 21480agaaaaaaat aaaaaagatg tcagttatgg ctatttgtac
tttattatac ttcatgtgat 21540gatatatggt tcagcatcag ggtctttttt cagttaagtt
cagttgaacc cttttcctgt 21600ttagaatatt ttttaaaagt ataaaaaaac ttaataaaag
aaatggatgg ctgggcatgg 21660tggctcaccc ctgtaatccc agcactttgg taggctgagg
cgggcagatc acctgaggtc 21720aggagttcaa gaccagcctg gccaacacag tgaaactcca
tctctactaa aaatacaaaa 21780attagctggg cgtggtggcg gccgcctgta atcccagcca
cttgggaggc tgaggcagga 21840gaatcccttg aacccgggag gcggagattg caatgagcct
attgcgcaac tgcactgtag 21900cctgggcgac aagaaggaga ctccgtccct cccataaaaa
aaagaaatag atgactacat 21960ttaaaatatc ttccatttaa atccatagtt tacaaataaa
ggaaaaagca gtggaggaag 22020agagtgagat aattacttca tttttacaat gttaaataat
tacaattaaa atttttgtgt 22080acaattccac atttaatagc aatttgcaaa tgccttattg
ccaggtgtgg tgtcttacgc 22140ctgtaatccc agtactttgg gagcccaagg tgggagaatt
gcttgagccc tggaattcga 22200gaccagcctg ggcaacatag cgaaactttt gtctctacaa
gaaataaaat tagccaggtg 22260tggtagcctg catctgtagt tggaggtact gggggagctg
acgtgagagg attgcttgag 22320cccaggaggt tgaggctgca gctgacatca agccactaga
ctctatcctg ggcgactaat 22380tgagaccctg tctcaacgaa caaagaaaca aaaaaaaccc
aaatgattta cttaccatta 22440aataccaaga aaagaatgac tggagtaagc ttagatttag
atacaacaaa atcatggagc 22500ttatcatttg aaaggcattt ttgacttttc ataggtgtgt
agcaagcaaa gtggtccttt 22560tgaaaaatgc aagtcacatc atgtcacttt tctgcttggc
ctttgcctac ttctcgaatg 22620gttctcctag cacattctaa ctggtcatta ttcattgtgt
ttcagccatt ctggccttca 22680acctatttct caaacacccc aatcttgggt atactttagg
gcccttgcat ttgctagctc 22740atttacctgg aaaattctgc ggtaacttct tgcacataat
aggtgctaat aaatattggc 22800tgcatgcaac caaaaaagct ggcttcggta gtagaagtag
tagaagagaa cattaccaaa 22860gtcctttttt ttgagacaag atttccctct gttatttagg
ctgagtgcag tggtgccatc 22920acggctcact gcagccttga cttcttggac tcaaatgatc
ctcccacctc agcctcctga 22980gaagctggga ccacaggtgt gtgtcaccat gcctggccaa
tttttttatt tgtagagaag 23040aggtcttact gtgttgccca gaatggtgtc aaactcctgg
gctcaagtga tccacctgcc 23100tcagcctccc aaaatgctga gattataggt gtgagccact
ggtccagcct cttaccaaaa 23160tctttttttt tttttttttt tgagacggag tctcgctgtg
tcgcccaggc tggagtgcag 23220tggcgggatc tcggctcact gcaagctccg cctcccgggt
tcacaccatt ctcctgcctc 23280agcctcctga gtagctggga ctacaggcgc ctgctaccac
gcccggctaa ttttttatat 23340ttttagtaga gacggggttt caccatgttg gccaggatgg
tctcgatctt ttgacctcgt 23400gatccaccca cctcggcctc ccaaagtgct gggattacag
gcatgagcta ccgcgcctgg 23460ccgcctctta tcaaaatctt aaacttgtta attcttgtat
ctcaccttgc ttttatatca 23520gtttttgtta tagaatgtgc tttcttttta ggttattttt
cttctgctca gcaagttaac 23580tttgaagaat cttttttttc ttgccttttt tttttttttt
tgagacagaa ttttggtttt 23640gttgcccagg ctggagtgca atggcgcgat ctcagctaac
ggcaacctcc acttcccggg 23700ttcaagtgat tctcctgccc cagcctcccg agtagctggg
attacaggca tgaggccacc 23760aggcctggct atttttattt tttatttttt atttttattt
tttactagag acagtgtttt 23820tccatgttgg tcaggctggt cttgaattct cgtcctcagg
tgatccaccc gccttgacct 23880cccgaagtcc tgggattaca ggtgtgagcc agcgcacccg
gcctcttgcc ctctttagag 23940cagttctaca taaatctgtg gaataatctg ctgacgttag
aaataaacct ttctcagggt 24000gtggccataa tctggttcgt tgtaattgct gaaggaaaaa
actgaaccct taggaacagt 24060ttaaacattc taggtggttt ttagatatat tattcctgtt
agagttttga actttgatca 24120tcttgttaga aaaaagaggc caggcactgt gcctcatacc
tgtaatccca gcattttgga 24180ggctgagtcg tcaggaagtc acttgagccc aggagtttgg
taccagcctg ggcaacatat 24240ggagacctcg tctctacaaa aaaaaaaaaa aaaaaacaaa
acctgttagc caggcgtggt 24300ggctcatgcc tgtgttccca gctactcagg aggctgagat
ggaaggattg cttgagcctg 24360ggaagttgcg actgcagtga gctgtgattg tgccactgca
ctccagcctg ggcaacagag 24420taagaccctg tctcaaaaaa aatgaatttt tgcattcatt
taaaaatgaa tggtagcaac 24480attttagata ataacttatg tagtctgtgt gaatctcatc
aaatatatgt gatttttaat 24540gcttggaatc ctagaatttt agtgagggag gagctctcaa
gttatctaat ttactgtcat 24600tttacagata aaaactaaac ttctgataga tgaaaggatt
tataccatac atctatatga 24660taattgcata tggctgagtt gaggttagaa cccaggaccc
aatctttgat ttgatttctt 24720ttcattatgc caatttagaa taaaattttt tctcttggtt
ttctgacctt tggccacttc 24780atcttttgaa ggatcttgta agttccttga tatttctcaa
aatgtcagtt ttattctctt 24840caatgaaagt tcttgttagg tgaaagtagc ctttcatatc
cttaaatgtg aacctgttcc 24900ttaggctgga gtttttgtac tctccattat attggcattt
atagttgttg gttttctttt 24960ttttttttct tttgagacgg agtctgtctc tgtcgcccag
gctagagtgc agtggcgcga 25020tctcggctca ctgcaagctc tgcctcccgg gttcacgcca
ttctcctgcc tcagcctcct 25080gagtagctgg gactataggc gcccgccacc atgcccggct
aatttttttg tatttttaat 25140agagacgggg tttcactgtg tttgccagga tggtctccat
ctcctgacct tgtgatcctc 25200ccgcctcggc ctcccacaag tgctgggatt acaggcgtga
gccactgcac ccggccagtt 25260gttggttttc ttttctgtgc cagattgagt gatatatggt
ggtactaaga gcactggaat 25320aggagtcaag gactgaggta cagcatagca cctcatgtat
tacttggtat ctccacttgt 25380ctctaacact gaagaggtat aattggttgt ttaaaaactg
tgggtgtaaa acgctagtat 25440cccatgaaat ggaactgcag aatataagtg gatgactctg
aaactgcttt tgaaacaagc 25500atgagggctc agtttctcca tctctcgtgg gctccaccat
cactgtctga catcctgatc 25560tcctaaggca tctttcctcc atcccagagc tctgttgaaa
atctcttggg ctaaaaacca 25620gtacagacct tctgatactc acgttctagc ctttttagat
tgttgtgtgt gaagagtaag 25680tcagctgtgg atatttttct ttcctatttt gtgaggcatt
tggtatttac tggaggctgc 25740ctgttttgtt gcaaaccttg ttccactgtg tactatagga
ggtctgctca gaaagcctag 25800ttagtagagc agtaccattt gctttggtca attgtagcag
cagtctgttt tttttttttt 25860tttttttttt tttgagacag agtcttgctg tgttgctcag
gctggagtgc agtggtgtga 25920tctttgctca ctgcaacctc cgcctcctgg gttcaagcga
ttctcctgcc ttggcctccc 25980aagtgggatt gcaggtgtgt gccaccatgc ccggctaatt
ctgtattttt aatagagatg 26040gggtttcacc cccaggctgg tcttaaactc ctaacctcaa
gtgatccact tgcttcggcc 26100tcccaaagtg ctaggattac aggtgtgagc caccgtgccc
ggccagcaat ctggttttaa 26160aggaggcttt gacccctcat ttggtaaaag gttccttctt
tgactaattc ccaaaggaca 26220tctcgatctg tcttcaaaag aaggggtatt ccgttgtcag
tattcctagc tagctctggg 26280agaagagaga acttgattgt tttcagggcc ctggtcagag
tctggtttta tgcccaaggg 26340atgaactgcc ttttgtcctt ctacctcctg aagttcagag
ccctgtgaaa atgaagtggt 26400aaaggtcaag tagcagtagt ttgaaaagca ccagcactgg
gacgattttg tggtagccta 26460gcagagtggg caggatgctt acttcagagg tgctaaagat
gtattttttt ttggaacaag 26520aaggttataa atgtttctat taagtttgat tttaaagcat
gagggttctg ggaaaatgag 26580aagattgtac atactctagg cttccttggg actgcatttg
aaaaaaaaaa aacttttctt 26640tgggtcagcc agtatgaaaa ctgcatttga tctcaatcct
tcagatcagg cttttgggga 26700gagttagttg aagaatttgt ttagtctaag aaagttgctt
ctagcttagc taaatctgga 26760agaaaaaatg gaacctgatg tttgagtgct aactgtattc
cagacagacg ttatactcct 26820tatattggtc cttttgaagc ataaatatgt ttccaagtcc
tataataatg aggaaattgc 26880ctgtgagagt ttaagtaaat tgtacaaagt aacacttttg
gttcagagat ttgtttttaa 26940tacagagagg acaggttagg aactttgaag cttcagctaa
atgagtcagt tctcaaatgt 27000ttgagaagca tgctcaagga tctggaggaa tagcttaatt
aatttgtaca tcatgagagg 27060agtagggagc aaaaatatgt ataatttctt ctgaatgatg
ctgtcttttt tgatgcagtg 27120gtgctaaatg ggctttgctt gtatgatact tcttaaatgc
attagctaat tattttgttt 27180tagtcttctt ttttgaaata cagatgactc tttgagctgg
ttttctttgg aaagttatct 27240gtcctgacaa ttctacttct aaaacttcaa cttttttttt
ttagtcttca tttccattgc 27300caccacccta tcctaaatta tcccgttatg ctggatactg
aaatagcttc tgcctggtct 27360acttactttc acttcgcccc cttacgatcc agtgctttgc
tccttttaat ccagtggcca 27420gagggatttt tttcaaaaca taatttgatt ataacagatc
tatgtttgat acttatccat 27480ggtttcccat ggcagttgca gaaaaatcca aaccttgttt
ggccacactg cccttctttc 27540agtaatttga attccttaag ctttttccag tttcaggatt
tcccattttg aactctttct 27600cctccacttt ttcctggcca caggtttcaa gagctgacaa
cttacctcag ttcttaagag 27660gatccttcat ttatctctaa attggatttt cctgtgtcca
aaccttactt gttatcacaa 27720gtttataatt atttgggtga ttgtttgatg tgtctctcct
gactgggcct taggggcaga 27780gaatctgtat tattttgttc ttgtttatat ccctaggagc
tcttatggta ggtattcaat 27840aaatgtttgt tgaataaagg cagtggaaaa acacatagaa
gaggtgctgt ggcagcagtt 27900ctcagtgcca acagttgaat tggtttacaa tagtaatttt
tagtgtcaac aaggagatgt 27960gtagtatgga atgtttatta gcaagatctt tttctcatgg
aatggaatgt ttgaaaacct 28020ccaaagtgta agtttttttt tttctcaaaa gaaaacagtc
atatttgggg ttactttttt 28080ttttgagaca gagtcttgtt ctgttgccca ggctggagtg
cagtggcatg atcccggctc 28140actgcaacct ccacctcccg agtttaagta attctcatgc
cttagccact ggaatagctg 28200ggattacagg tgtgtgccac catgcccagc tgttttttgt
ataattatta gagatggggt 28260ttcgccatgt tgaccaggct ggtctcaagc tcctggcctc
aagtgatctg ccagccttgg 28320cctcccaaag tgctgggatt acagatgaga gccaccgtgc
ccggcccatt gttacttctg 28380aaatcgaaat caaatgccat attgattcct gatcttttgt
gtatgacctc tctctctctt 28440tttttttttt ttttgctacc tctccccgaa agtttttagg
atcttttttt ccacgattat 28500gtaccttgat gtgggtcttt tctcgccctt tgtgctatta
ggtctagcaa ctcatgtgtc 28560tcaggtctgg gaaatgattt tacagttttt ccagctggtg
cgtaactagc tgtttgttct 28620gatactgtca gtatttaact ttatgttaga aacatttcat
aatgcaaatg aaaaatttaa 28680gccaggtgca gtggctcatg cactttgtga ggctgaggtg
ggaggaacac ttgaggtcag 28740gagttcaaaa ccagcctggc caacatggtg aaaccccttc
tactaaaaaa acaaaaaaac 28800aaaaattaac tgggcatggt tgtgcacccc cataatccca
gttactcagg aggctgaggt 28860acgagaatca ctggaactgg gagacaggtt tcagtgagcc
gagactgaga cagagcaaga 28920ccctgtctca aaatataaat aaaatacata aaaaatttaa
tattatgtat ataatatcca 28980gcccaggctt ttctatttgt catgccctgt ttctttcaca
tcatagcctt actcagatgc 29040ctgctgatcc ttgattgagg tgtgatgctt gagagtcagg
ctcttaaata ctactggcga 29100attcagtgca ttgtggtttt gtgacttcac ttgtctctta
cagaagtggg gaagtggttt 29160ttacttcgat gcatggttct gaagtagaga tgtctatctc
ctgatgcaca ctttaaataa 29220tccccatgtt ttccactcca tactccatcc ttgtctggtt
taagctctta gcctgtctgc 29280agttcagggg atgaatctgc ttggttcttt tcagcatctc
cctctgcaac gcttagatct 29340catcttcctt tgctttgcta actattctct ttgcttctcc
atttgtttct ctgtcattga 29400tgacttccaa gttatatccc catcctggat attccttttg
aacgtcagac tcatatattc 29460agttacctcc tcagtatctc tattcggata tctaatggca
tctcaaaatt aacatgtgca 29520aaaccaacct gttccaccct tgtgttggct gtataaatta
gtgggaactc cattttttaa 29580gttgcttaaa tcagaaacct gggagtcatc aattttggag
tctgtccctt tgctcttgtg 29640gcacatgtaa tcacgaataa atcctgttgg ctctatcttc
agaatatatc tcattttatc 29700actctctctg ccaccagagt ggtttaagcc accttcatct
cttaggttat tttagtagct 29760tcctaactgg tctccttcct tccattcttg ccaccttcct
caacaccgaa gatatatttt 29820atttatttat ttatttattt tgagacagag tcttgctctg
tcaccccagc tggaatgcgg 29880tggcttgatc ttggctcact gcaacctctg tcttccaggc
ttaagcaatt ctcctgcctc 29940agcctcccga gtagctgggg ctgcaggcat gcaccaccat
gcctggctaa tttttgtatt 30000ttttagtaga gatggagttt caccatgttg gccaggctgg
tctcgaactc ctgacctcag 30060gtcatctgcc cgcctcagcc tcccaaagtg ttgggattac
aggcgtcagc caccatgctt 30120ggccaaattt tttattcctt tgggtaaaga gatgtatttt
atttccttta atttggtaat 30180atagtgagtt atgttaatag attctttttt tccagtgctc
aagcatcctt gcattcctag 30240gataaatggt acttcaacat gattttcctt ttaaatatac
attgctggat ttaggttata 30300aattattgag aatttttgca tctgtattta caagtgttac
attctaattt caggcctttt 30360ccagttttat tatcaaaaca agctgtgctg tttttcctct
cttgattctc agtagtagtc 30420tctttaagat agtgattatt cattcttttt ggtagatcat
gcctataaga cctgggcatg 30480tatgttttta ttgtgggaat atattgtttt tactttcctt
gttatgaaat atataattta 30540ttttaaaata tgtatataca gagtttgtgt tcctttaaag
aataatagct aaaaataaat 30600tgcacgcccc cacatccaac catcgtcaaa caaaacatct
tttacactct attttattta 30660tttattttcc cccacccctc tagagtatac acccttttgg
agcctctgag cattttcctt 30720tccctcactg ctttagaaac ctctattcag atttttcata
ttaatgattc ttttgctttt 30780aacccacatg tgttactgaa gtttaagtcc taaataataa
tttttcctgc tttaaaatat 30840atttttatgt caatgaaatc atactggtgg atgtattttc
tctgatttgc tgcttttgcc 30900tctcatttct gagcttgatc tatgttggtg catttataga
aatacttcat attttctgct 30960gtgtatcatc ttatgctatc aacgtgccat atgatttacc
tgttcttagc atgtatttgg 31020gttgtttctg gttcttgctg taacaaacag ctgcatttag
tgcttgtgta tgtgtctcct 31080gatgcatgtg tgcattcact tctctggggt gtatatgttg
ctgggaatgg gactgagtat 31140tgtgagtgta taatagtatc ttgtttttgt tttttttccc
tctcagttta tggcataatt 31200tacgtacagt aaaatttacc accgcccccc tgccccgcct
ttttcttttt ctgaaacaga 31260gtctcgctct gttgtccagg ctggagtgca gtggcacaat
ctcggctcac tgcaaccttt 31320acttactggg ttcaagcgat tctcctgcct cagcctcaca
agtagttggg attacaggtg 31380cctgccaggc taattttgta gagacagggt ttcaccatgt
tggccaggct ggtctcaaac 31440tccttacctc aggtgatcca cccaccttgg cctccccaag
tgttgggatt agaggtatga 31500gccaccacgc ccagccaaat tcaccctttt tagtgtacaa
gtatacagct ttgtgagagt 31560ttgatttctt tagttcaaat ttgttttaaa gttatatttg
gtattttaac agtgctattt 31620aaatatatgc catatatggc ttgaatgcaa ttatcctagt
acagatggtc cttgacttat 31680gatgtttttg tgtccctgta agcccacctt aagttgaaaa
tattaagttg aaaatgcatt 31740taatatgact aacctgctgt aaatcctaac ttagcctacc
ttaaatgcac ttagaacact 31800taaattagtt tacagtgggc aaatcatcaa acacaaagcc
tatttgtaat aaagtgttga 31860atatcttata taatttattg aatactaaag tgaaaaacaa
tagttgtatg agtagtcaga 31920gtatggcttc tcttcaatgc atatcacttt catataccat
cgtaaactca aaaaatcata 31980agtcagggta tgctgtatat tttattggtg ctaacatact
tccattttaa aatacaggaa 32040attcaccttt ttttgtgtat agtcttgtaa gttttgacag
atctatatac agatatgtaa 32100tccccaccca tgattctttt ttaatttaaa aaaatatatt
tttgagacag tctcactgtc 32160acccaggctg gaatgcagtg gcatgatcgt agctcactgc
agcctcaaac tcctggcctt 32220aagtgctcct cctgcctcag cctcccaaag tgctaggatt
acaggaatga gccagtgtgc 32280cctgccacca ccataattaa gatccagaac agtttcatca
tcccagaaac tttccctgta 32340tccttttgta gtcagcttct tttttcaccc ccagctcctg
gtgaccactg atttgttctc 32400tgtccttgca gtactgtctt ttccagaatg ccatataaat
tgaatcctac attatataac 32460actttgagtc tggcgtcttt tacttagtgt gaagtatttg
agatttattt gtcttgtgat 32520gtgtattagc aatttatttc ttttttcttt tttttctttt
tggagacaag gtcttgctct 32580gtcacccagg ctgaagtgca gcggcacgat catagttcac
tgcaggctta aactcaagca 32640atcctcccac ttcagcctcc tgagtagctg ggactgcagg
cgcacaccac catgttcagc 32700taattttttt tttttcttgg tagagacagg atctcactct
gttgcccagg ctgatttcaa 32760actcctggcc tcaaggaatc ctcccaccta tgcctctcaa
agtgctggga ttacaggtgt 32820gaaccattac agttggctag cagtttattt ctgtatattg
caggatagta tctcattgta 32880tagatgtacc acattttgcg tattcattct tcagttgata
gacatttgga ctacttcctc 32940cttttggctg ctgtgagtaa tgctgctgtg aataaatatt
tgtgtgtaag tttctatgtg 33000gacatacagt ttcattattc ttgggtagat aaaccttgga
gtaattgctg ggttgggtgg 33060taatttctgt ttaactttta aagaaatagc taagctgttt
tccaaagtgg cttcaccatc 33120ttaaattcaa gtttttgttt tcgttgtatt tgaggcagag
ctttactctc ttgcccaggc 33180tggagtgcaa tggcaagatt atattatagc tcactgcagc
ctcgatcttc caggctcaag 33240cgatcctctc acctcagcct cccaggtagc tgagagtaca
ggtgtgtgtc accatgcctg 33300gctaagtttt gatttttagt agagataagg tctggctatg
tttcccaggc tggtcttgaa 33360cttctgagct caagcagtcc tcctgccttg gcctcccaaa
gtgctgggat tgcaggtgtg 33420agccaccaag cccagccaag gtttttgtgt tttagtaaaa
tttctgctct tcctggcaat 33480acttttttct gaaatttact ttgatattga tatagtcact
ccagttcttt tcagtgctta 33540gtttttgcat ggtatatttt ttccatcctt ttgtgttata
ctgtctgttt cattatattt 33600gtagttggac cttgattttt tttttttccc taattctttt
acttgggatg cttggaccta 33660atgtgtgtct agtttttcct aatgtgtctt ttacttggga
tgcttggacc atgtgtattt 33720aattattgat atggttgggt taagtccacc atctagctat
ttgttattta tttattttta 33780gagccaaggt cttgctgtgc cacccaggct ggggtgctag
tggcatgatc atggctcact 33840gaagcctcta acttctgggc tcaagcagtc atctcactgc
agtctcccga gaagctggga 33900ttacaggcgt gtgccaccaa gcctagctga tttttttttt
ttttttccga gatggagatt 33960tgctcttgtt gcccactctg gagtgcagtg gcgcaatctt
ggctcaccgc agcctctgcc 34020tcctgggttc aagcaattct cctgcctcag tctcccgagt
agctgagatt acaggtgcct 34080gccaccatgc ccagctaatt ctgtattttt agtagagatg
gggtttcact atgttggcca 34140ggctgatctt gaactcttga cctcgtgatc tgcccgcctc
ggcctcccaa agtgttggaa 34200ggccgaggcg ggcagatcac gcctgtgctg ggaggctgag
gcgggtagcc actgctccca 34260gccctgaaat ctttcctctt ttctaagata gacatttaat
gcacacacac attttgatat 34320gctatgtttt aattttcatt cagcttaaaa tatctaattt
ttcttttgat ttattcttta 34380acttactgat tatttagaag tgtgatatta tattttggga
ataaaaatcc agagatctta 34440ctgttactga tttttgattt aattccattg tggtaagaga
acatacctta tatgatttga 34500atccttttaa attgattgag acttgtttta tggatcagaa
taaggtgtct tgataaaggt 34560tccacgggca cttgaaaaga atgtgtattc tactgttgtt
aggtagagca ttctattaat 34620gttgattggc ttgttgattg ataatgttca agtcttctgt
attcttaccg atttcctatt 34680ctatcagtta tagacagagg gtgttaaaat ctcaattctg
ttttgcttgt tgattgataa 34740tgtttaagtc ttctgtattc ttaccgattt tctgttctat
caattataga gagaggtgtt 34800aaaatctcaa ttctgtttgt ttttggtttg aaatttactt
ataaggtaca taagcattta 34860tgattgtcgt catcttgatg aattggtctc tgtcattttg
aaatgacaga acttactttg 34920tctcataata tagctactcg tgcttttcat ttgattagtg
tttggcatat atttttatat 34980tttaaaaaaa cttatcacct gtgtctttat gtttaaagtg
gttttttttc ccaggcatca 35040tgtgtttggg atcttgcttt tatccagttt gatagtgttt
gccttttaat tggagtttgt 35100agactattta tgtttaatgt gattactgat ttttttttga
gatggagtct cgccctgtcg 35160cccaggctgc agtgcagtgg cacgatctca gctcactcca
acctccgttt cccgggttca 35220agtcattctc ttgcctcagc ctcccaagta gctgggactg
caggcacctg acaccacacc 35280cggctaattt ttgtattttt agtagagatg gggtttcacc
atattggcca ggctggtctc 35340aaactgctga ctttgtgatc cgcccacctc agcctcccaa
agtgctggga ttacaggtgt 35400gagccactgc ggctggatgt ttactgattt ttatagagtt
taaacaacca tcttttctat 35460ttgtctgatg tggtgttttt ttcgtttttg tttttttaag
atggactgtc actctgtcgt 35520ctaggctgga gtgcagtggt gcaatctcaa ctcactgtaa
cctttgcctc ctgggttcaa 35580gcagttttcc tgtctcagcc tcccaagtag ctgggattac
aggtgcgtgc caccacacct 35640ggctattttt tttttttttt ttttggtttg agacagagtc
tcgcactgtc acctgggctg 35700gagtgcagtg gcgcgatctc ggctcactgc aatctccgcc
tcctgggttc aagcgatact 35760cctgcctcag cctcccaagt agctggtatt acaggcgccc
atcaccacac ccagctaatg 35820ttttgtattt ttagtagaga cagggtttca ctatattggc
caggctggtc tcaaattcct 35880gaccttgtga tctgcccgcc ttggcctccc aaagtgctgg
gattacaggc gtgagccacc 35940gtgcctggcc taatttttgt atttttagta gagatgggct
tttgccatgt tggccaagca 36000ggtctcgaat tcctgacctc aagtgatccc tgcccttggc
ctcccaaagt gctggcatta 36060caggagtgag ctacgccatg cctggcctgg attgaggatt
ttttagtggt tcatttttaa 36120gtcctttctt ggctcattag tactttgtta ttttagtggc
tgctttagtg tttattgagt 36180tcagcttgtg aaactcagtc tttaatatta taccacttca
cctatattac aagaacctta 36240tagcagtaca cttcattttc ccttcagact ttgtgctatg
tttgtcatac acttcacttt 36300tacatatgtt gtaaactcca caatacatta ttatttttca
tttaagtagt caattttttt 36360aaaacaattt tttttttttt gagacggagt ctcactcggt
tgcccaggct acagtgcagt 36420ggtgcaatct tggcttactg cagcctctgc ctcctgggtt
caagtgattc ttatgcctca 36480gcctcctgag tagctgggat tacaggtgcg ccccatcatg
cctggctgat ttttgtatta 36540ttagtagaga tggggttttg ccacgttggc ccagcaggtc
tcgaactcct gagctccagt 36600gatccgcctg tcttggcctc ccaaagtgct gggattacag
gcatgagcca ccatgcctgg 36660cctaaaaaga ttttaaaagt aagaaaaaat gtcttttact
ttatatgttt tccatttctg 36720gtgttcttta ttgcctatga gcggttccag attctcatct
gccagatttt cttcagtttt 36780ttctcgtcag ttcagatttt ctttctgcca gaggacttcc
tttaatgtgt ttcttgtagt 36840gtaggtctgc tggtgatatc tttaagcttt ggtgtgtttg
aaaaagtact tcctcttgtt 36900tttagaaaga tatattcctt tgatacagaa ttctaggttg
acaggttttt ttcattgtgt 36960actttaaaga tgttgctcca ctgtctctag cttgcattat
ttctcctgta aaatctgttg 37020ttattttaat ctttgttctt cagcgagcaa atttatcttt
tttgcctttt ttggttaatt 37080tttaagattt tctttttatc actgcttttt cagcaatgtg
tttattatat actttgttgt 37140agtttgcgtc atatttcttg tgtttgaatt ctcttgagct
tcatggatga aatttacgta 37200ttcagctact atttcttgaa atatttttct tttgtacttc
cccaccgcat ctggagtctg 37260taattacatg tatatttggc tgcttgaagt agtcatacaa
ctcactgatg cactgttatg 37320ttttttagtc atttgattct ctttgttttg ggtagtttct
actgatcttc atttcactag 37380tctttatctt tcccatgtta aatctgttac tcttatccag
aattatacct tttatcctta 37440aaaattcagt ttttttcttt tttttgagac ggagtctcat
tctgtcaccc aggctgaagt 37500gcagtggcat gatcttggct cgctgcaacc tccgcttccc
aggttcaagc gattatcctg 37560cctcagcctc ccaagtagct gtgattacag gcatgcatca
ccatgtctgg ctagtttttg 37620tatttttagt agagacagag cttcaccatg tttgccaggc
tggtctcaaa cccctgactt 37680caggtgatcc acctgcctca gcctcctaga gtgctgggat
tacaggaatg agcgaccaca 37740cctggtttgt ttcttaaaaa acatcttata tttctctgct
taacgtgctc aatgttgaac 37800atgtgaaata taataacttt tcataatctc ttctgattct
gtctctatat catctttggg 37860tctgttttta tgtattctat ttttcttgtc attatgggtc
agatttccca gttctttgca 37920atcctaataa attctgttta gatgaaagac attgtgaatt
tcactttggg ttgtggatat 37980ttttgtattc atgttggtat ttttgagatt tgttctggag
tgcagatgag ttagctggaa 38040actaattctt ttgaggcttg ctttttagct ttgttaggtg
gggcgtatcc tttctgtgtt 38100tatttttgta agggtataca gatatacatg ttttcttatt
tccctcttta tttattctta 38160tttaatctgt aacaatcttt ttccttatat tcgtaacatt
cttagttagg gagtaattac 38220ctcttcccta actgttgcat tagcttctta attggcactc
tggttcccag actttttctg 38280tctctaatgc agtgtacaga ctactgtcag aataattcta
aagcacaatt ctgatattgt 38340cactgtattg cttttcagtg cctacagcag taggattcac
ttaaaaaatt attcccctaa 38400tagtaatata aaaaattttt ttgagctcaa actctcattc
tctctcagta tacatatttg 38460tttatacatg aggtcacata ctgcttacta agttagcatt
ttttatgtgt tcattttgaa 38520ataactctga acagtggtat ccaatctttt ggcttccctg
ggccacatta gaagaagaat 38580tgtcttgggc cacacataaa atacactaat gatagctgaa
tagctaaaaa ttaaacattg 38640caaaaaaaaa aaacaaacaa aaaaaactca ctgtggcttt
tttttttttt ccctgtattt 38700ttctttttcc cgagatgaag tcatgctctg ttgctcaggc
tggagtgcag tagtgtgatc 38760tcggctcact gcaacctccg cctaccaggt tcaagcagtt
ctcctgcctc agcctcccga 38820gtagctggga ttaaaggggt aagcccccat gcctggcctt
tttttttttt tttttgtggg 38880gtgagcgacc atgcctggct tttttttttt tttttttttt
tttttttttt ggtagagatg 38940gggtttcatc atgttggcca gtctggtctc gaactcttga
ccttgtaatt cacctgcctt 39000ggcctcctaa ggtgttggga ttacaggtgt gagccaccac
tcctggcctt tttttttttt 39060ttttttgaga tggagtctca ctttgtcacc caggctggag
tgcagtggca tgatctcggc 39120tcgctgcagc cactgcctcc cgggttcaag cagttctcct
gcctcaccct cccgagtagc 39180tgggattaca ggtgtgtgcc accactccca gctagttttt
tgtattttta gtagaggcag 39240gtttcaccat attggccagg ctggtgaact cctgacctca
agtgatgcac ccacctgggc 39300ctcccaaatg ctgctggaat tgcaggcgtg agccaccatg
ccaagccaat tgtgttttaa 39360gaaaagttta tgaattagta ttgggcagca tcgaaagttt
acaaagtttg cgttgggccg 39420cattgaaagc tgtcctgggc tgtgtgcgac ctgctggccg
caggttggac aaacttgctc 39480tgggacataa gtttaaaagt tataggccaa gtgccttggc
tcacgcctgt aatgtctttg 39540catttcatca gtttttccac tgttatcttt ctgttacagt
acacggtcag aataccacat 39600tgcatttagt tgtcatgttt ccttagatgt gaaacaaatt
taccaattgt agtagggtat 39660ttacgtatag atcggttcgt ttgtagcctt atagtatcta
gttaaaacac tgttataaag 39720ttattgttat gtatcctttt gggtgtggtt tctttcctta
gaaaaataca tttaaaattc 39780attcatgttg ttaaatgaat caataggttg tttctctttt
aaaaattgag atgaaattca 39840cataacaaaa ttaaccattt tattttttta attttatata
tattttctga gatggagtct 39900cactctgtag cccaggctgg agtgcagtga cgcgatctcg
gctcactgca acatctgcct 39960cctgggttca agcgattctc agccttaacc attttaaagt
gcacagttaa gtggcattta 40020gtacattcac agtgttgggt aaccatcttt atctggttcc
aaaacatttt tttttctttg 40080aaagaaaacc ccgtatttat taagcatttt tctctctgtc
cttttccctt cactcgcttc 40140tggcaaacac cagtctgctc tgtttctgtg gatttacctg
ttctggatat tttatacaaa 40200tggaatcata gcgtatgtag ccttttgtgg ctggttttgt
tttttttgtt tgtttttttt 40260tttgtttttt ttttttgaga cggagtcttg ctctgtcgcc
caggctggag tgcagtggcg 40320ggatctcggc tcactgcaag ctccacctgc cgggttcacg
ccattctcct gcctcagcct 40380cccaagtagc tgggactaca ggcgcccgcc actacgcccg
gctcattttt tgtattttta 40440gtagagacgg ggtttcaccg ttttagctgg gatggtctcg
atctcctgac ctcgtgatcc 40500gcccgcctcg gcctcccaaa gtgctgggat tacaggcgtg
agccaccgcg cccggcctgg 40560ttttgtttta gtaagatact tttgctggat taagaataag
gttgggccag gggtggtggc 40620tcatgcctat aatcccagca ctttgggagg ccgagttggc
ccagcctggc caacacagtg 40680aaaccccatc tttactaaaa atacaaaaat tagtcaggca
tggtggcggg taccttgtaa 40740tcccagctac ttggaaggct gaggcaggag gattgcttga
acccgggaag cggagtttgc 40800agttagccaa gatcatgcca ctgcactcta gcctgggcga
caagagcaag actcgtttca 40860aagaaaaaaa aaagaatacg tagttgacag gttttttttt
ctttcaatac tttaaagatg 40920atataccact gtcttgtcac tcaccttgtt tctaacaaga
aatctgctat ctttgttctg 40980tattttgcat gctttttttt tccttgctgc ttttattatt
ttctctttat tactggtttt 41040gagcattaga ttatgatatg ccagtatggt ttttcttgtg
tttattgtgc ttgtggttca 41100ttgatgttct tggatatgtc ggtttatagc tttcttcagg
tttcggattt tttttttttt 41160tggccatttt tttcaaatta ttttccattt aatttctctt
ttctttttag tcaggtactc 41220tttatccaaa cattaggctg cttgaagttg ccccatagct
tactgatagt ttttgtttta 41280acctgtgttt tatttgaaag attctatttc tgtgcctttg
aatttacttt cttttgcagt 41340gtgtaatctg aagttagtca catttagcat ttttaaaaat
ctcacatatt ttactctttt 41400tttttttttt tttttttttt tttttttaaa gactgagtct
cactctgttg cctgggctgg 41460ggtgcagtgg cacaatttca gctcactaca acctccgcct
cctggtttca agcgatcctc 41520ccacctcagc ctcccgagta gctgggacta caggcacccg
ccactacgcc tggctcattt 41580ttgtatttgt agtagagacg gggtttcgcc atgttggcca
ggctggtctt gaactcctga 41640cctcaagtga tctgcttgcc tcagcctccc aaattgatgg
gattacaggt gtgagccacc 41700atgcccggcc atattttacc tttttttatc gttagaattt
tgatttggtt taaaaaaaaa 41760tctttcctgt ctctacttaa gtttttgaat atatgaaatg
cagatataac tcttataatg 41820tccttgtgta ctcattctaa catctgtgtc atttcagggt
tggttgcaat tgactattct 41880ctttagtata cttttttttc cttgcctctt gcctggtgat
ctttgattgg atttcagaca 41940tagagagttt tacctcgttg ggtgctgggg atatttgtat
ttctacatat gttctttaac 42000tttgttattg gatgcagtta agtcacttga aaaccgttga
ttcctttagg tcttgtttgt 42060aagatttgtt agctgggaac ggtgtagtag ttggtttatg
gctaattctt cctcacttct 42120gagacaagat tcttcccaaa tcttgagggt tgtcttgaga
tttccagtct aatagctact 42180tgagtgggta agggcagagt actgttcata attcttttgg
gtgttgtttt cctctccttg 42240ctgcccatgg tcttgggtag tttcatcaca ctatgggcca
ctcagtactc agtgagtacc 42300tctctagatc tcctcagccc tctactgtgt ggtattgtcc
catgaattct agctgcctaa 42360gtcctgcact ctgagctgag ctcgctgtct tcaattttga
gttctgcagc ctccataggg 42420cttctgcttc tgcatggtgc ccaggaaact ctcttcaggc
actaagtttg gccatcatag 42480gactcatatc tttgtttctc ttcctttggg gattactgtc
tctcattgcc tgctgcgcag 42540catcttgaaa gctatagttt catgttttgt tagttatttt
agtggtttaa ggtgagaggg 42600taaatctggt ccctgttgtg cttgaaaagt ttttttcaac
ttttctttta gaaataattt 42660taggtttact aaaagctgca gaaataatac agagttctga
ggtgtctttc acccacttcc 42720cccatgataa cattttacat aaccatagta tagttattaa
aactaggaaa ttgacattgg 42780tataatagtg ttaactaaac ctcatgcctt atttcatatt
ttcacatgaa ctattttgag 42840ctggcatggt taatatacag ttctatgaag ttttatcacg
tgtatagatt tcgtgtaatt 42900atcactagtc aggttataga agtattccat cattttaatg
aaatgccttt gtactactcc 42960tgtgtagtca tcatgtcctc cttccagcct ccaccaccaa
tcaaccaacc aactttaatc 43020ctggcagcta ccagttgtct gaattttatc actttcgcta
taattttatc tttctcagaa 43080tgtcataata cagtagtccc cgttatctgt ggtgatatgt
tctaagaccc ccagtggatg 43140cctgaaacca gctatagtac tgaaccatat atgtgtgtgt
gtgtgtgtgt gtgttttttc 43200cccccccccc tttttttttt tgagacggag tctcactctc
gtcacccaga ctagggtgca 43260gtggtgtgat cttggctcac tgcaatctgc acctcacagg
ttcaagcgat tcttctgcct 43320cagcctcctg ggtaactggg attacaggtt cgtgttacca
cgcaggctaa ttttttgtat 43380ttttagttga ggtggggttt caccatgttg gccaggctgg
tctcgaactc ctgacctcaa 43440gtgatccacc caccttagcc tcccaaagtg ctgggattac
aggcgtgagc cactgcacct 43500ggcctactat acatatacgc ctatgatgaa atttaattta
taaattaggc acagtaagag 43560attaacaata ataaaaaatt ataacaatat actataataa
aagttatgtg aatgttgttt 43620ctctctcaaa atactgtaat attttcaggc tgcagttgac
catgcgtagc tgaaagcaag 43680ggtaagtggt gactactgta aatagaatca tataatatgt
tacctttgag attggctttt 43740cttttttaac tcggcaaaat gcctttgaaa tcgatccaag
tcctatgtat taacactgtt 43800tctttttatt ggtgagtagt attctattct tgggcacact
acagtttacc cattcttcca 43860ttgagagcat ttctcccccc taaattacaa acagagatgg
agtcttgctt tgtggttggt 43920ctccaactcc taggctcaat ctatcctcct gcctcagcct
cccaaagtgc tgggattaga 43980ggcatgtgcc actgtgcctg gccccactga agaacatttg
agttgttccc agtttggggc 44040tattacaaat aaagctgctg tgaacatttg catgcagatt
ttagtgtgaa aatattttta 44100tttctctagg atgaatacct acctatgagt agaattgctg
ggtcgtatga tacatgtata 44160tttaactctg taagaaacga ctacactgtt ttccagagtg
gtggtagttt ttcattccca 44220ctaacaatgt ataagaaatc caattgttct gcttttttat
tagcacttta gtattgtcag 44280tatttttcct tctgttcatt gtaatagatg catagtagta
tctcatgcct taaatttgca 44340tttccgtagt ggctaatgat gttgaatatc ttttcatctc
cttaggttcc atttgaatat 44400tctctttggt gtagtttatg ttcaagactt ttctattttc
aaattggatt ttttcttact 44460gttgagtgtt ctagacacaa gttatttgtt ggatacgtga
tttgcaaata ttttctccta 44520atcttttaat ttgcctaaga gtgtgcttca tagagcaaaa
ggtttgaatt cttatgaagt 44580ctaatttatc tatttttaaa ttttatagtt ttttttggtg
tcatatctaa gcactctttg 44640gctaacaaaa ttttctcttt ttttctaaaa gttgtatgct
ttacatttaa gtctgtgatt 44700gcatttgaat taatttttaa attaagcata aggttacatc
aatgttcatt ttcctttttg 44760ggggaccaat tattccaaaa ccatttgctt aaaatgatta
ttctttattt attgaattgc 44820tttctcacct ctagcaaaag tcagttggcc atattttgtg
aaaagttcta ttcctacgca 44880cactgttctg gctcattgac ctacgcatct gttcctctgt
caataccgta ctgtcttgat 44940tactgtaatg tagctgtata gtaagtccta aaatcaggta
gtgttattcc tccaccttcg 45000tttttctttt tcagagttgt ttcagctatt ctggtttctt
tgtctttaca tggaaatttt 45060atttatttat tatttatttt cttgagacag cctcagtgtt
ttgcccgggc tggggtgtgg 45120tggtatgatc atagttcact gctgcctgga attcctgggc
tcaagggatc ctcctgcctc 45180agccttccgg gtagctggga ctacagatgt acaccaccac
tcccagctaa tttttacttt 45240ttttgtagtg ctggggtgtc accctgttgc ccatgttggt
ctcaaacacc tgggctcaag 45300tgatcttcct gcctcagcct cccaaagtgc tgggattaaa
ggcatgagcc accacagtca 45360gctgtgtatg aattttagaa tcatattatc tacaataaag
ttttggtgga gtttcaatag 45420taaatgcatt aaacccattg gttagtttgg ggagaagtga
catcttggcc atgttgtctt 45480ccagttcatg gatatagtat gtttttttac atttatttag
gttgtctttt ttttttaaag 45540gtacataata attgtacata tttatggggt gcatgtgata
ttttgataca ggtatgcagt 45600gtataatgat caaagcaagg tatttaggct atccatcacc
tcaaatattt atcatttctt 45660tatgttggga atttttcaac tcttcccttc taggtatttt
gaaatataaa caaattatag 45720ttaactacag tcaccatact gtgctgttga accctggaac
taatttcttc tatctaactg 45780tatgtttgta cccattgacc aacccctctt tatctccctg
cccccttccc agctctggta 45840acgatcattt tactctctgc ctccacgaga tcaactcttt
tagctcccac ataggagtga 45900caacatgtga tatttatctt tctgtgcctc ttcctttact
taacaatgta tttaggtcat 45960ctttggtatt tttatcagca tttcataggt tttagcatgc
atattttgta cagttttgtt 46020agatatatac ctagtttttt ttggtaaact attataaatg
aaattgtgct tttaattttt 46080gtttctaatt gctgattgct aatatataga cattattgat
gttagtgtgt tgatctgtat 46140tctgtgacct ttataaactc acttattagt tctacaagtt
tttctcctag aatctttggg 46200attttctctg ttagaccatc atatcatctg ttaatagggc
cggtttaata tattcctttc 46260tgatatgtgt accttttatt tccttttctt gcttgattga
ctagctggga cttgtttgct 46320gtgtcgaata tgagtgctta gtgtggacat tcttgcctta
ttcccgcttt cagatagaaa 46380gcctttagtc tttcaccact agtatgatgt tagttataga
cattttatag atggtcttta 46440tcaagttgag gacgttttct tctattccta gtttactgag
agtttttatc atgaatgtat 46500ttgttgaatt ttgtcaaagt ttctgcattg atataaataa
ttatgctttc ttttcacatc 46560ttattgtttt agtttgcatt tccttgatga tgaattcctt
ttcatatgct tactgaccat 46620tttatcatct tcctgcgtga attttctatt agttttgccc
atttaaaaaa agtttttatt 46680ttgtagcaat tttaagcttt cataaagttc taagtacagt
acaaagaact ttattttttc 46740ctgacccatt ttagagccct gttgttcctt actattttta
tttatttttt gagacagggt 46800ctgtcactct gttgtacaga ctggagtgca gtggtactat
catagctcac tccagggcat 46860aaacgatcct cctgcctcag cctcctgagt agctgggaca
agtgtgtgcc accatgcctg 46920gctaattttt ttaattttaa ttttttgaac ttctgggctc
aagcgatcct cttgcctcag 46980cctcccaaag tgttgggatt ataggcatgc accaccgcac
ctggccctac ccttaatact 47040ttagtattaa tgttttagta tatttgcctt aaagttaatg
acattctcct tgctacctgt 47100ccacaataca ttcataaaat tcagaaaatt acactgagtc
attattacca tctaatcttc 47160agatttcatt aaagtttagc taattgtcca tgtaatgtcc
tttttgtcca aagtatctag 47220gtcagaatta tgtgttgcat ggagttgtca tatgtctttg
gtctccttca ttctagaaca 47280gttctttaat ctttctttga ttttcgtgac cttgactcct
ttgaagacta cagaccagtt 47340attttgtgga atctttttta gtttgaattt tctcataatt
ggattcaggt tttgcatctt 47400tgtcaggtat agcagagaag tgatgctagg ttcttagtgt
gtcctgtcag gtagctcttt 47460atttcagttt tttcctatta ttgattatct ctttgatcac
ttggttaagg tagcatctgc 47520catccttcat cactataaag ctccttttta cccccacccc
tttttttttg agatggggtt 47580ttgctcctct tgcccaggct tggagtgcaa tgtctcaaaa
aaaaattaat agtaatatat 47640acagtcatag ttagaagcca agatctagtt tctaaatgtt
tgctgctgtt ggagtgttgg 47700tgatcccagt tcctttcagt gggaaggggc taaggaatat
atgggtatat ttacatacat 47760acacatatgt tcactcaatc tatatttata tctgtcttta
tctaaatatg ttgaaaacta 47820tgagcttacc ccaataatac aagttctaat ccagtcattc
tagttttttc cctttccata 47880tgtataagtc ctttttccaa caataataaa tctgggctgg
gcgcagtggc ttacacctgt 47940aatcccagca ctttgggagg ctgaggcggg tggattgctt
gaacacaggc gttctagatc 48000agcctgggca acatgtcaaa accccatcta tatggggaaa
aaaaaaaaag ttagccaggt 48060gtggtggcac atgcctgtag tcccagctac tcaggaggct
gaggtgggag gatcacttga 48120gcccaggagg tcaaggctac agcgagccga gattgcacca
ctgcactcca gccagagcta 48180ctgagtgaga ccctgtctca aatctattcc ctaatatatt
tacctaatta tttaatcacc 48240cactcttcac tgttgcagcc ctttcttcat gcagatgtcc
tctttacttt gcttggactc 48300caacaccctg tgttgggttg gctccactct catcccatgg
atgagttcac tcaagctctg 48360accagtcaca tcagggtgtt ctcccatata catgcccttc
tcaacccgcg tgggcttcaa 48420tactctgtcc tttgtcattc cctgtttggg catttcactc
atcttgatct ccaactctca 48480cgtcatacca cactcagata cacacagata ccttctgtgc
tccactcagg ctctgactct 48540ctactcttgt ctacctagcc tcaggcctcc acttttgtat
ggatgcctac cttgctgtgt 48600accatgtaat ggaagggaag actagtttgg gggaagagaa
gggcagctct tcccatttaa 48660aaagattggt ttgtcttttt gttttaggtt tatagaattg
aaatatatag gtgggcttgg 48720tggctcacgc atgtaatccc agcactttgg gaggctgagg
caggtggatc actttggttt 48780aggagtttga gattagcctg gtcaacatgg tgaaacccca
tctctactaa aaatacagaa 48840aaattagctg ggtgtggtgg agggtacctg taattccagc
tactcagaag gctgaggcac 48900aagaattgct tgaacctggg aggtggaggt tgcagtgagc
tgagatcgtg ccactgctct 48960ccaacctggg caacagagct agactccgtc tcggggggaa
aaaaaagaat tgaaatatat 49020gtatacacac acatatacac actctggata catactgtat
cccgagtatg tgttttgcaa 49080atattttctc ccagtctgtg gcctgccttt tatttctttt
cttttttttg agacagggtc 49140ttcctctgtc acccacgcta gagtgcggta gcacagtcac
aactcaccgc agcctcaact 49200tcctgggctc aaagtgatcc tcccacctca gtctcttgag
tagctgggac tacagacacg 49260tgccaccact cctggcccat tatgtctgtt ttttgtagag
atgacgtctc actatgttgc 49320ctagggtggt ctcaaactcc taggctcaag tgatcatccc
acctcagcct cccaaagtgc 49380tggtgagcca ccatgcctgg cctggcctgg cctgcctttg
catttttatt aaagtgtctt 49440ttgattagaa gtttttttgt tttgaggaag tctgttttat
ccacattaaa acaatatgtt 49500tttaggaact tttgcctatc tattaatagt gcacaaaaat
attttttggc tttatatttt 49560tggctcttag gtgtgcgatt tatgtcaaat taatttttat
ttttgagagg gagtctagct 49620ttgtcaccca ggctggagtg cagtggcaca atcttggctc
actgcaatct ccacctccca 49680ggttcaagca attctcctac ctcagcctcc tgagtagctg
ggattataag cacttgccac 49740catgcctatt tttctatttt tagtagagat ggggttttac
catgtttgcc agcctggtct 49800tgaactcctg acctcaggtg acctgcccgc ttcagcctcc
caaagttgct gggattacag 49860gcttgagtca ccatgcctgg cctcaaatta atttctatgt
acggttcgag gtagtcattc 49920aggtttgcgt ttttacgtgt ttatcttgtt tcagctttat
ttgttgaaat gatgttcccc 49980tctttattga atagctttgg tgcctttgtc aaaaatcagt
tgagtccata cataaggata 50040tgtttttgta ctctgttctg ttccattaat ctatctattt
ttataccaat attttactct 50100cctgatttta gtaagtcatg agattggata gtgttagtag
tgtgaatcct ctgtgttctt 50160ccttcttaaa attgcttgga ctgcttttgg ttctttgcat
ttatttttct ttctttttta 50220gagacaaggt cttgctctgt cggcaggctg tagtgcagtg
acgcagtcct agcttactgc 50280atcctaaaac ttccgggctc aagccatcct cctgcctcaa
gctcccaagg cgctgggatt 50340atgtgtgtga gccaccatgc ccagccttct ttgcattttc
atataaattt tagaatcaac 50400ttgtcaattt ttatcaatta aaaaaattgg gattttgatt
aggattatgt tgactttgta 50460gggagaatta acttctcaac agcatttttt ttcaatccat
gaacatggta taatctccag 50520ttattatcat ctttaatttt tcttagtgtt ttatagtttc
caatgaggtc ttgcatgcct 50580taacattttt ttctcaagta tttttatttt tttaattttt
taaattaatt tatttttttg 50640agatggcgtt ttgctcttgt tgcccaggct ggagtgcagt
ggcggaatct tggctcactg 50700caacctttgc ctcccagttt caagcgattc acctgcctca
gcctccctag tagctgggat 50760tacaggcggg caccaccata cctggctaat tttttgtatt
tttagtagag acagggtttc 50820accatgttgg ccaggctgtt ctcaaactct tgacctcgtg
atctacctgc cttggccttc 50880caaagtgctg ggattatagg cgtgagccac catgcccagc
ctcagctatt tttattttcg 50940atgctattat acatggaatt tgttttaaaa atttgtttcc
cagttttttg ccctagcagg 51000tatatagctg atttttcaat aacttgtaat tttgacataa
tttcagacac gattgtattt 51060gctttataat tctagctaca tgttattttt ttcatgtact
aaagtgcaga cataatgccc 51120cctaacctct aaatagttat taacaacaag tacattctct
ttcataacca cattgcaatt 51180atcaatgtca gaaaattaat gttgatatgg tactgcttgc
tgtctaatgt gcatactttg 51240agctgggctt ggtggtatac acctatagtc ttagctactc
aggaggctga ggtgggagga 51300tcgcttgagc ctaggagttg aaggctgcag tatgccatga
tcaaccctgt gaatagccac 51360tgtactccag cctgggcaac aatagtgaga tccctatctt
taaaaaaaaa actgcatatt 51420ttactgaaat tttacctatt cttttctaat gccaattata
aagcaaaatt ctggttgagg 51480atctcatcct tgatcacatg gtacatttgt ttgtcaaatc
tcattttctt taatctgaaa 51540aagttctcac aaacattgtc ttttatgact taattttttt
taaagtacag accatttatt 51600ttgtattaat agtaagttct ccaatatgga tttgtcttga
tgcttttcat tattaaagta 51660atgtttttga caggaatacc tcagcatgtc ctcctcagta
cattttatca ggagacacga 51720tacctgtttg tctgatttct gataacgata acttcaaaca
cttggttaag gtggtgtctg 51780ccttatttct ctcctataaa tagtaccttg tagagagata
cagtagtccc ctttatctgc 51840tggggatgtt tcaagaccag tgggtgcctg aaattacaga
tagtcccaag ccctatatat 51900actgtgtttt ttcctatgca tatgtacttt tgataaattt
tattttatta ttcctttatt 51960tagtttttag aaatacggtc ttacaccgtt gcccagcctg
gtcctgaatg aacttctggc 52020ctcaagtgat cctcctgcac tggtctccca aagtgttggg
actacaggtg tgagccactg 52080tgcccagccc cccaagttta atttctaaat taggcacagt
aaaagaataa caacaataac 52140taagaataaa atataacaat tgcaacaatg tactataatc
aaagttatgt ggatgtgatc 52200cttctttctc tctcaaaata ctgtaatttt ttggactgct
gttgaccaca ggttatttaa 52260actgtggaag gtgaaacttc gggtagaggg cacttactgt
actttgagac tatatgaata 52320gtctcatgta ctttcattca ctggttttag catccactga
tgaaggattc ctacctaaaa 52380cagttagtac gctgaggctg ggtgcagtag ctcacacctg
taatcccaac actttgggag 52440accgaggtgg gtggatcatt tgatgtcagg agtttgagac
cagccttgcc aacatggtga 52500aaccctgtct ctgctaaaaa tacaaaaaaa ttagctggac
atgatggcgc atgcctgtaa 52560tctcagctac tgggggaggg tgaggcagga gaatcgcttg
aaccctggag atggaggttg 52620cagtgagctg agatcgtgcc actgcactcc agcctgggca
acagaacaag actctgtctc 52680aaaaaaaaaa aaaaataaaa aaaataaaaa aaaattagta
ctctgagagt tgttgtcaag 52740tggtgatttt tttttttttt aagttccacc atttatctga
catctattag ttgtggtttt 52800tcagtaaggg ggagagcttt aatttattcc cccatttgtt
tattcgttgt gaatttatgg 52860attctttttt tttttttttt tttttttttt gagatggagt
ctcatgcgct ctgtcaccca 52920ggctggaatg tagtggcaca atctcggctc actgcaacct
ctgtctcctg ggttcaagtg 52980attcatcttc cttagcttca cgagtagctg gggttacagg
tgcctgccac catgcccggc 53040taatttttgt ctttttagta gagacggttt caccatgttg
gccaggcttg tctctccaac 53100tcctggcctc aagcgatcca cccgcctcag cctcccaaag
tgctgggatt acaggcataa 53160gccactgtgc ccggccatgg attccttttt tttttttttt
ttttttaaaa tatgaagact 53220cgctctgttg cccaggctgg agtgcagtag tgcgatcttg
gctcactgca gcctctgccg 53280cctgggttca agtgattctc ctgcctcagc ctcacaagta
gctgggatta caggtttgtg 53340ccaccacacc cagcttttat atttttagta gagatggggt
ttcaccatgt tggccaggct 53400ggtctcgaac tcctgacctc aagttatcca cccgctttgg
cctcccaaag tgctgagatc 53460ataggcatga gccattatgc ccagccctac ccatggattc
ttattttatt attgagttat 53520aatcttacta tcatttttaa tgtacaaatt gtcgctgatt
tggccagtgg aattgcatgt 53580actccagctt ttgtgtcctt tttatgtgtt ttcctcattc
ctgaacactt ctttacttac 53640ctgctttctg acccagcaag atgttctggg cttagcttat
attttcccag ccccacttct 53700agaatcatcc attttcctgg ggagctctgg tttcttttag
cttagaatag tatgcatgta 53760tacatctgta cctgtttctc tctttgtctg tctataggta
aatatagtat tcatactaat 53820accttgaaat tagtctctta ctgggggttt cattctaact
ttacctttct atatgtgcat 53880cttgctactc caacattgaa caacctggct tctattatgt
actttgtatc tacctacttg 53940ctcagtttta gtataaacac ttagtagttt tataattgtt
aacccattcc actgtggaag 54000aacaaatcta actagaactc agtatttgtt tatagttcat
ttaggttttt agcctaagga 54060tatatagtca aaatacttga agaattactt gggttagatc
tgtccttgtg ccccttcagt 54120gtggttatgt tattcacttt aagtatatgt cagtaaaaat
tttaaatgta tcacaaccac 54180ttcctctttt tagtgctgtg ggaaaacaag cactgttgca
ttacccttaa gaaaagaaat 54240aaattttttt tttttttttt ttggaaacag gtctcactct
gtctcccagg ctggagggca 54300atggtgggat cgtagctcac gtcagcctcc caagtagctg
ggactacagg catatgcatc 54360ctggctggct aatttttttt tttttttgca gacatggggg
tctcactatg ttgcctaggc 54420ttatcttgaa ctcctgggct caagtgatcc tcccgccttg
ccattccaaa gtgttaggat 54480tataggcgtg agccactgtc cccaggtcaa gaaaacaaat
ggatactttt ttttgttggg 54540ggatttgata ctattaacaa aattatattt gcatctacct
tttgaccgat tgtttccatt 54600tgattattca aggcagtagt atttgtagtt gcagaatatt
aaaagccatc taaatgctgg 54660tggtacatga gggagtggtt atactttgat acatcaacat
catggagtat catgcagctg 54720agaagaaaat gaggaagttt tcatgaaacg atagagtaat
ttccagaata tattgttaag 54780tggaaaattg aagagcaaaa tactctctga ggcacgcaga
ttttgttgtt gttgttgttt 54840aaggatgaag gataaataaa acagatgtgt atattatcat
ttgtacaaaa agaaacacaa 54900gaagaataca ccggaaacaa tgaggttggt taggggacta
acaggaatgg aatggagagt 54960tggaggggga tggaaatgga agggatggtg gggagcagtg
tcacttactc tgagtataac 55020cttttatata gttttgattt gtaatcatgt tatatttcac
ataattcaat atgtagataa 55080aataacaaag atgggaaata aaaaacaaaa tgggttacaa
acaaaagatg aaacccagtg 55140ctattaacag ctgtacaatt cttgatgtgt tcaacgtatt
tcattcttct ttctgaatgt 55200ttgttcctgg agccatcttt tttcctgctc tccgcatgga
cagtttgtgg tgtaaggtgg 55260ccagccatcc tggtttgccc acgattgagg ggtttcccgg
ggtgtaggac tttcagtgct 55320aaaactggaa actcccaggc aaactggggc ctgttggcta
ctcttttcac gtgcatgtgg 55380ctgttttcct cggactttcc ttatatgtac cttgggaatt
ctcttcactt tctcctggta 55440tgtcctgcct ttcctagatc tcacacaaat ctcatttatt
gttactcctt tagttgtgtg 55500cgcattctct acacaataca tttatgtaga gcagattgac
gtagagttgc ttctagagaa 55560caggtgccta ggaggtaaat tgaggcctta catgtcttta
ttctgtgttc cacactagat 55620tgttggttgg gctcagaatt ccagaagatg ttactcttac
tactacattc ttcagagctg 55680cttttgagaa acatgccatt gtgatttctg gatatcgtgt
gttttttttg accggaagat 55740tttaggatct gtttctctcc tgtgttttga gatttcatga
taatgctgtg gaatgggtct 55800ttttcattca ttatgctgag tgttttgcct tattaaactc
ggaaactgga gtcttctcat 55860ttggggaaaa tttcttgtat tatttctgtc ttttggcttt
cttcctctgg accttctatt 55920tgttggatgt gggactctct taatggagct tctttttctt
tttttttttt aatcagttct 55980ctaggagata atctgttgtt tttggcctct catttttaat
ttctagcaga ttgttcatgt 56040tctttaatgt tgctttattt ttttaaaaaa atattctggc
tgagctgtag tacgtgtctg 56100tggtcccgac tactggggag gccaaggtgg gagaattgct
tacgaccagg agtttgagtc 56160cagcctgggc aacatagcaa caccccatat cttattttaa
aaaaagcact ctatgtttgt 56220tttgggcctc tttgagaaca tttactatga aattttattt
atctttgttt cctttcagtt 56280cttcttttgt ttattgtgat tatctttcat ataacaatgt
gcttaaatag ctggtggttc 56340ttgataggtc actcaacagt gagcaaactg atggatcctg
tgtttgtgag cagtgtttat 56400tggctgtgat agagggtggg gacctagatg cttttagggg
atcctcctgt tatccatttc 56460tgaaagtgtt ttctcctagg ctggtcactt tttccaggag
gagaaatcct ttcatctctt 56520gccatctaca tgacagtagg ctgtggttgg ggtcatagta
ctactactat ttggggagct 56580ttgggagcca aggtggggag ggaagctagt ggtgtcatga
ttttctggtg ttttttgttt 56640gtttgtttgt ttgtttgttt gttttgtttt gtttgagatg
gagtttatct cttgccgccc 56700aggctggagt gcagtggtgc catctcaact cactgcaacc
tctacctcct gggttcaagc 56760aattctccag cctcagcctc cctagtagct gggattacag
gtgcccgcca tcacccctgg 56820ctaatttttg tatttttagt atagatgggg tttcgccatg
ttggccaggc tggtctcgaa 56880ctcctgacct caggtgatct tcctgcctca gcctcccaaa
gtgctgggat tacaggtgtg 56940agccaccatg cccagcctgc gtcatgattt tctattgttg
gtcttattta gagtgtggca 57000tctcactcca tgccccatcc cttgagctgt gcctctagtc
ttctgttcca gaacttccgt 57060ggttcagttt aatcagaata taaatctgtt ttcctctgga
gtgggagaag ggtgtattgc 57120cttactgttt agggacagga aggagacctg agggggtctg
actgttttat tcagagtttg 57180aaacagttct cctgttctca gcccctgcct ctcaactctt
gtctgcagtg gttcctggtg 57240cctcccactt ccctgcgtgc tccgggcttt tgaagcactg
gcttgctttt tgtggctttt 57300ccctctgcag ccataaactt caactttcct tctttgctga
gtcagttact tcttaccttc 57360ctgctcaacc tggtctttca gatttctgtt gacatccctc
atctactgcc tttttccttc 57420cccttactct ttgtctttat gcatgtacac ttttactgtt
cccttatagt cattctagtg 57480aaccctcagg aagatgcaaa gaagtatatg ttcattttgc
catgtttatc cacaaccccc 57540aaataccatt aaacaaaaga aaagaaaaaa tatttaaaaa
agaaaacaaa aacaaaaaca 57600aaacaaaccc ttaataaatg gagagcagct atgccatgtt
gttgattaag aagattctat 57660atcgtaaaga tgtcagttct tcccaatttg atttgtagat
tcaatgcagt acactacaaa 57720ttttgaaaat tgagatataa tagttatatg tattttgggg
gtacaggtga tattttgata 57780cctgtatgca atacatagac atttttcttt gtgttgggaa
cattaaaatt cttcttttct 57840agttattttg aaatatatag taaattattg tttactataa
ttttcctatt ctactattga 57900atattagaac ttactccttc tatttaactg taattttata
ccccttaacc aacttctatt 57960ttgccatgtt taaatatgga agctcaagcg tttgtacaga
gaaagtggaa aatgcccttg 58020gcttttatgc caaaccccaa tccctctgtc cccacctgcc
accctggcct gttgcccctg 58080ttcttcccag tagctacaac cactatcatt aatttaacgt
gcatcctcct attcatatgg 58140aggtatgtgg tatgtttgtt tatataagtg tattttattt
tctttaatgt ttaatagtgt 58200accatatcaa tatagctaca ttttatttat ccagtcccct
gctatgaata tgtgcgtttt 58260tcactgtttt ctaatccctg ttataaacac tgcagcaaca
cttatcctta atctccatgt 58320acaaacgtgt gagaatttct ctaagggact attcccttac
cttttcatat tgtatgcttg 58380ggtaaaatgg aagtgacttg gaggctcttt ctgtgggggt
tagtgaaaag atttcattac 58440attttctttg cattttgtaa ttatgatgag aaaaatataa
aacttataaa tcttttttaa 58500aagttttgag aaacatgctt tgttacgatc atgacatcaa
gttttatgct taaaaagtct 58560gtaattcctt gtgtttaatg atgaactctt caaattcctg
atacagatct atagtccctt 58620attaacaatt ctgaaatcca aaatattatg agaactgaat
ttttttcccc ttgactgatt 58680tagtagtaaa acctgacctg tgtaaactca ttttgtgtca
aaactctgat gtagattgac 58740aggtctaggt tagcttattt gtttcacttg gtctttgtct
acattttatt tttttaaaaa 58800ttaatgtgtt tgattatggg ttgctggtgg tgctgataca
caatatatgc atatattaac 58860attctaaaat tcaagaaatt ctaaataaaa acacatctag
acccaaagat ttcaggtaag 58920ggattgtgga cctgtggtca ccattagcta gaaagtttca
gctgtgagtg gcaacttaca 58980agaatttctt tctggttgat agaaactcct ttcttattat
tagtaagaac tcagacaatt 59040tctttacgtt atattccaag agtgtgttca ttttttaaat
aacagctctt ccttttcttt 59100cgttgacatc tataatattg aaattgcttt tgataatgca
aatggatttc acattcaaga 59160gaaccttttt atgttaagta ttttgtttaa atggagaagc
cttttctcaa gcatgtatgg 59220agattgcttt ccttgtttta attcttcttt aggattttca
tgagaaaatt aaaacatcat 59280taatggacca ttttagccac agttttccaa agttgcattt
tgactttgga tctttaaact 59340ttctgtatac tttaataggt atgtgtaggt ttaaaaaaaa
tttttttttt ttgatcagaa 59400tcttttgttt taggccaggt gtggtggctc acacctgtag
tcctagcact tgaggctgag 59460gagggtggat tgcttgcgct caggagttca agagcagcct
gggcaatatg gcaagaaccc 59520catctctaca aaaaataaaa aagttggccg ggcgcggtga
ctcatgtcag taatcccagc 59580actttgggag gctgaggcag gcgaatcacg aggtcaggag
ttcgagacta gcctggccaa 59640catggggaaa ccccgtctct actaaaaata caaaaaatta
gctgggcata gtggcaggcg 59700cctgtaaccc cagctacttg ggaggctgag gcaggagaat
tgcttgaacc cgggaggcag 59760agattgcagt gagctgagat ggagccactg tactccagcc
cagatgacag agcaagactc 59820tgtatcaaaa aaataataat aataaataaa tacaataaat
aaataaataa attagcctgg 59880agtggtggtg catgcctcta gttccagcta cttgagaggc
tgaggtggga agatcactta 59940agcctgggag gtcaaggctg caaatgagct gtgatagcac
cgtggcactt tagcctgggc 60000ccgcacagtg agaccctgtc tcaaaaaaca aaaacaaaaa
atacgtttta gaactatcag 60060ttaaattttg taagccattg tttacctact ttaattggga
tttaattcat agaccataca 60120gttcaccaat ttaaagtata caattcagtg gcttctagta
tattcatgaa gttatgcaac 60180catcaccatg gtctgattgc ataatatttc catcacccca
aaaggaaacc ccagtaggtc 60240attcctattc tcacctcctc ctagtcccta gcatcaccag
tctactcatt taattactaa 60300aactttctaa aaagcaactc ctctcatctt gttcttcaag
agtatcttgg ctctttgtga 60360ccctgtgctt ttccatgtaa aattctgtaa aagatcgtgt
tgagagcttt attggaactg 60420cattgaatcg acaaatcaaa atgggaagaa ttgacatctt
tttttttttt tttttttttt 60480tttttttttt tttttttttg agacggagtc ttgctctgtc
acccaggctg gaatgcagtg 60540gcacaatctt ggcctactgt aatctccgcc tcccagcttc
aagcgattct cctgccttag 60600ccttgcgagt agctaggatt acaggtgcac gccaccatgt
ctggctaatt attgtatttt 60660tggtagagat ggggtttcat catgttggtc aggctggtct
tgaactcctg acgtcgtgat 60720ctgcccgcct tagcctctca aagtgctggg attacaggct
tgagccacca tgcccagcca 60780aattgacatc tttatgatat aaaatcttct taatcaagaa
catggtatag ctctccattt 60840atttagggtt tgtttgtttt tgtttttttg agacagggtc
ttgttctgtc tctcaggcta 60900gagtgcagtg gtgcgatcat agctcgctgc aacctgaaac
tcctgggctc aagcaatgct 60960cccacctcag cctcccgagt agctgagact acaggtgcgc
gtcaccatgt gcagctaatt 61020tttgaatttt tttgtagagc gggggtctcc ttacgttgct
catgttggtc ttgaactctt 61080gggctcaagt gatcctcctt cctcagcttc ccaaagtgct
gggattacaa gtgtagccaa 61140catgcctggc cttaccaagg ttttaagcct ttcttgataa
agttttatgt tttcttcata 61200aaatgatgat atttcttttg tggaatttat ccctgggtaa
cttacgttcg tttttgttat 61260aaattatatt tttgttataa attatatttt tgttttcttt
tttcttcaac cctggcaaat 61320ggatatattt tctttttttt tttttttgag acagagtttc
gctcttgttg cccaggctgg 61380agtgcagtgg caccatgtca gctcactgca acctccgtct
cccattcagg caattctcct 61440gcctcagcct cctgagtggc cgggattaca ggcgtgcgct
accacgccgg gctaattttt 61500gtatttttac tagagtcagg gtttcaccat gttggccagg
ttggtcttga actcctgacc 61560tcagatgatc cacccacctc ggcctcccga aatgctggca
ttacaggcat gagcccccac 61620acccggctga tggataaatt ttctaattga tgatgttaat
tggtgatgtt agtatcactt 61680gatttttcct tttttttttt tttaatgtga tctcaaatgt
cacaatgtgg ccaaaatctt 61740ttactaggtc tgagtctctt ggatctttaa tgtaaataat
tatgctatct ggaaattatg 61800acatgctttt ctaatccctt cttgtttcta ttatgcattg
aaaggaattc tagtatactg 61860ttgaatggtt ggtgttttct tagtttttca cagccttcaa
gtcagccttc tcctaagaga 61920tagtacttat tttttgctca ggaaagatat aaggaaaggc
ataactgata ttttgctttt 61980ttttttactt cagaatctaa tcttgggcag tttaaacttt
atcaatttaa atgttagctc 62040tcctttgctc agatttgcca cattcgtagt gtcttgtatt
ttttaaaaca tctgacctgt 62100gggagaacat tttattttgg tttacttatt acagatggtt
tatttttttt caacattagc 62160ttcttttcta gttaccttgc caaactagta tacgttatgc
attttagaaa cacttatttg 62220tattaataga tgaacgtgag taaaaagtat acagcaagtc
ttctttgtac tgttttactc 62280ttgcaaaagt agaatgaaaa gcttttgcag ctttcctgta
aaattgaatt tctttccata 62340taaaaatgtt caaaatgtat ttgtaaaagg aatacgtact
catcatcagt attaaaaagg 62400ttcagaataa agaatcccta caactacagt ttttaaaaga
caactcaaaa aaaaaatggg 62460tgaaagactt gaacagatac ttaaagagga agatatgaat
atggccaata agcacattaa 62520gaagtgctca tgcagccata aaaaagaatg agttcatgcc
ctttgcaggg acgtggatga 62580agctggaaac catcatcctc agcaaactaa cacaggaaca
gaaaaccaaa caccccatgt 62640tctcactcat aaatgggagt gaacagtgag aacccatgga
cacagggagg gaaacatcac 62700acaccggggc ctgttggggg gtggggggaa aggggaggga
gagcattagg aaaaatacct 62760aatgcatgcg gggcttaaaa cctagatgat gggttaatag
gtgcagcaaa ccaccatggc 62820acatgtatgc ttatgtaaca aacctgcaca ttctgcacat
gtatcccaga acttaaagta 62880aaatttaaaa aaaaaaaaac ttcaaaaaaa aaaaagtgct
caacatcttt agacattagg 62940caaattaaaa tgaaaatcat tgaaatctag cactctgaat
taaaattaaa accacaatga 63000ggtaccatta tactcccact agaatggcta aaataaaact
gccagcttca aataatggtg 63060aggatttgga tcaactggaa ctctcctcaa gtgctgttgg
gagtataatt ttttttttaa 63120taaagttagc tttcatccat cttatgactc ggcatttcta
ctcctagata gttattcagg 63180agaaatgaaa acgtctccaa aaatttacaa gaatgttcat
aatagcttta ttcataatag 63240ctagaacctg gaaataaccc aaatgtccat caagagagaa
tatacaaatg gttgtatatg 63300agaatattag tctgtaataa caaataatga actactgatg
catgcaacaa tgtagatgaa 63360tagcataaac aggctgagtg aaagaagcca gatacaaaag
aatatatatg tatgagtcca 63420tttacatgaa gaccaagaac aggcaaaagt acgttatgga
gatagaagtc agaacaatga 63480ttgccttcgt ggggtgagag gggtggtttc ttttcttttt
tttttttttt tttttgagac 63540ggagtctggc tctgtcaccc aggctggagt gcagtggcgt
gatctcggct cactgcaagc 63600tccgcctccc gggttcatgc cattctcctg cctcagcctc
ccgagtagct gggactacag 63660gcgaccgcca ccactcctgg ctaatttttt tttttttttt
tgtattttta gtagagacgg 63720ggtttcaccg tgttagccag gatggtctcg atctcctgac
ctcgtgatcc gcctgccttg 63780gccttccaaa gtgctgggat tacaggtgtg agccaccgcg
cccggccgag aggggtggtt 63840tcaaatgggg gttgattagg aaggggcaca aggaaacttt
tgggggtgtt ggaaatgttc 63900tatatcttga tatgcatttg ttagaactca ttaaatggta
cacctaagat ctgtgcatat 63960cactgtgttt aaattaaact ttaatttaaa aaaatagggg
aaggatagga ggaggtatac 64020attgatccaa gggcattctc ctacgtaagc acaatacagt
tatcacactc agaaaattta 64080acattaatgc agcattacca tctagtatgc agttcacatt
caaatatccc agtgtcttga 64140aatttgctga gagtagatct taattgtctt cacactcccc
atctcacact ctccctctca 64200tggtaactgt gtggtgaagg attggttaat tttttttttt
tttttttttt ttaaagacag 64260agtcttgcac tgtctcccag gctggagtgc aatggcatga
tcttggctca ctgcaacctt 64320tgccttccag gttcaagtga ttcttgtgcc tcagcctccc
gagtagctgg gattacaagc 64380gtgcaccacc atgcccggct aatttttgta tttttagtag
agacggggtt tcaccatgtt 64440ggccaggctg gtctcgaact cctgaccttg tgatccaccc
gccttggcct cccaaagtgc 64500tgggattgca ggcatgagcc accgtgcccg gcctatagaa
ttttttatat gtaggattta 64560gtgaaagatc acccattatt aattttttta aaagcttcat
gatgaaaatt attcttgtaa 64620aatgttaaaa tcttgaatcc tagggcatgt tttctggcac
ctgttatttt cagtaaccca 64680tttcgttttt gtcagacata tagggttaat gtatgaaaag
tcaattatgt caaacttata 64740gagtttatat ggaaagatta atgatctttt acaaatgcag
aattggctgg atgtggctaa 64800ttgtagaatt ggcctgtaac ctagcactta gggaggctga
ggtgggagga tcgcttgagt 64860ccaggagttt gatttttttt tttaattttt tattttttga
gacagtctca ctctgtcgcc 64920ctggctgaag tgcaatggca tgatctcagc tcactgcaac
ctccacctcc caggttcaag 64980cgattcttgt gcctcagctt cccaagtagc tgggattaca
ggtgtgtgcc accatgccta 65040gctaattttt tgtgtgtgtg tgtatattta gtaggggggg
tttcatcatg ttggcccagg 65100ctggtctcga actcccagct tcaggtggtc cccccatctc
ggcctcccaa agtgctggat 65160tacaggtgtg ggccacaata cccagcattt tttatttatt
tatttattta tgtatttgag 65220atggagtttc accctgttgc ccaggctgga gtgcaatggc
atgatcttgg ctcactgcag 65280cctgcatgtc ccgggttcaa gcgatcctcc tgccacaacc
tcccgagtag ctgggaatac 65340aggcatgtac accacaccca actaattttt gtatttaagt
agagtcaggg tttcattatg 65400ttggtcaggc tggtctcgaa ctctggacct caagtgatct
gcctggcttg gcctcccaaa 65460atgctggaat tacaggcttg agccactgca cctggccaag
cccaggactt tgagaccagc 65520ctgggcaaca gaccaagacc ctgtctgtac aataaaaatt
atgcagtatt agaatagcaa 65580atcttactct taaaagtttt gttttccttg tctttttact
gaaaatgcat ggctttagaa 65640acttctgggt agtttgaatt gcagacaacc aggccctatt
cctgtttgtt taactaatga 65700gatttgtaaa cagtacttgg tttccccaga ctctaggacc
tagaggaagg aaattttgat 65760ttagctcttg gtaaagcatt taacacctaa tttttctttt
tcattgttat tttcttgatc 65820acagaaaaca atacatgtta atagtagaaa atacccacaa
ttgaaaagaa tataaagcac 65880ttactaaaac tctaccacct aggctaggta cggtggctca
cacctgtaat cccagtactt 65940tgggaggctg aggtgggtgg atcacctgag gtcaggattt
caagaccatc ctggccaaca 66000tggtgaaacc ccatatctac taaaactaca aaaattagct
gggcgtggtg gcagccacct 66060gtaatcccag ctgctcggga ggctgaggca ggaaaatcgc
ttgaacccag gaggaggagg 66120ttgcagtgag ccgagatcat gccgctgcac tccatcctgg
gtgacagagc gagactcttg 66180tctcaaaaaa caaacaaaaa aactgccacc tagagatggt
ggtggccaac agcttagtaa 66240gaatttctct tgcatttttc tatgcaaaca cattcaaatt
ttcatttttt aaaaaagatg 66300atagaatcat actgtatgaa tttaattgcc taattaagct
tgtgtatcat cgtttctctt 66360gtcattaaat gctgtacagc tttcttttaa atggctatct
gtggtagtgt tccttgaagg 66420aaatacctta aaattttttg tttttaaact tttataattg
tgggaatgta atacagtgaa 66480tgcataggac acaaatgttc agcttaagga attattataa
agtgaacacc ctgtaactgc 66540cacttagatc acgacatcaa atatggccag cagccaggcg
cacctcccct accccccact 66600gccccttccc agtcacagcc ccattcttcc agctgaaggt
aacttctgtc ttgactttat 66660gaaagttatt ttcttgcttt cctttagatt acctacccgt
ctttgcattc ctaatgctgt 66720agtttagttg agcttatttt gaacttttca caaacggaat
catcaactat gcattatttt 66780gtatctggct ttcattcact attttgtttt taatattcat
ctatgtcgtt agtagctata 66840gttcattcat tttttgttgc tgtataatca tccatttatt
gaatgtacta caatttgatt 66900ctgcctttgg cagccacttt gattgtttat aatccagatt
tcaaatgctg catcatgaac 66960atgtgggttg tgatttgtgt agatgtgcat gtacttctct
aaggaatcca agcctaggag 67020ggacgttgct gggtcagagg atgtttgtat cttcaactgt
accagataag gccaaattgt 67080attctcaaat gcttggatct gttttcagtg tacttgttct
actcctaatt aacactactt 67140gatattgtca aactttaatt gtagccattc tgatggatgt
ggtagtatct cattgcggtt 67200ttaatttgca ttattttgca ttttccttat tgttagtgag
attaaatacc cttttatatg 67260ttttggctac ttcagtatcc tcttgtgcag tgcctaattc
acatctttta tttttcttct 67320gagttgcctt ttgcccattg atttatattt gttccccctc
tctccccgcc cccaagaagg 67380agtctggctc tgtcacccag gctggagtac agtggcacaa
tcttggctca ctaacctctg 67440cctccttcgt tcaagtgatt ctcctgcctc agcctcccaa
gtagctggga ctgcaggtgt 67500gcgccaccac gcccagctaa tttttgtatt tttagtagag
acagggtttc accatgttga 67560ccaggcttgt cttgaacccc tgacctcaag tgatccatcc
gccttggcct cccaaagtac 67620tgggattaca ggtgcaagcc accatgcccg gcctgattta
taaatgtagt ctaaatacaa 67680gttctttatt ggttatgtaa gttgcagata tctttttcag
ctctgtaggt aataatgttt 67740tttgatgaat aggaggtctt aattttaatg tagtttaatt
gatttgtttt ctcctttgta 67800agaatcaata tttttcatgt cctgtgtaaa tctcgtattg
ggataaaaga tacatatata 67860ttttttaggt tttggctaat agttttccgt tggcagcatg
tgaacctttt tatgccattt 67920ttactttcat caagggtgta tgtatgattt tctcatactc
ttgtcagaac tggagatttg 67980gggtaacttt gccagtgtaa tagactttct taattcatta
aggagtattt tatcttagtt 68040tgcccatgag agaagagaga ttaaatttgt tttattatac
caagaacatg gcagtcaata 68100agcataacta aaaatattat ttagcttttg attctgaaga
ccatgtatgg ccagtaagga 68160aaagaggtaa agatgtagaa aactgttttc ttttttttct
ttcttttttt tttttttttt 68220tttttttgag atggagtctt gctctgtcgc caggctggag
tgcagtggcg taatctcagc 68280tcactgcatc ctccacctcc tgggttcaag tgattcccct
gccttagcct cccgagtagc 68340tggtactaca ggcgcgtgcc accacacctg gctaattttt
tgtattttag tagaaacagg 68400gtttcaccgt gttggccagg atggtctcaa tctcctgacc
tcgtgatcca cctgcctcag 68460cctcccaaag tgctgggatt acaggtgtga gtgagccact
gcacctggcc tcttttttat 68520taatttaaga tacatgattt tggctaaaac taatgaaaat
aaattgatga aacttcaatg 68580tagtggatca agagactcat gaaattgatg agttagattg
ttgtgggcac ctgttttaaa 68640tttatggtgc ctttttagca gaatcatgac tttatcaact
ctttttcaca tacttttatt 68700caaagaagac attctcctcc tctgccccaa cttatcttct
tcttgtctcc aactgccagt 68760attctcatcc acactctttg tagttttgag gtgtgagata
actcccaagt tcttcttggg 68820aatgggtaga gtttaattct gagtctacat gtcgtgagtc
tattggaaga agcttttctt 68880aggaggtgaa atttgggatg gagttctcct ctacactcta
gccctgtagc cacaatcttt 68940ggtttagatc tttggcattt tttgttggac atctttcata
gtgtctacct cttcttcctg 69000cctctaggct tcccgcggtt gccagatgaa attccgaaaa
ctcaaatcat tcctgtagtt 69060aatattcttc agtgactccg gaacaatcaa attcttgatc
cctccacatg ggtcttacca 69120tctgccctcg tgccctctct agcttcctgc atattgagtt
ccccacagcc ctagtttccc 69180tgagtttgga atattctttc acatttgctc atcccactat
ctagaaactt cctacaatct 69240ctctactgcc aacctgtctg tctagttgct aatttatttt
aaaacccagc ttaagcaaca 69300catccttttg gatgtgttac ttccctgatc gttattcacc
tccatgccgt ctttcgctca 69360actcattgaa gttaggtgcc cctcttctgg gctgccacgg
ctctccatgt tcacctatgt 69420actgtacttt gtattgtaat cagtttaatt gaccccccta
cttatttgag ctccttgaga 69480gcagggcctt gattcctgct ccttagcact ccaccctccc
cagaactaac atggtatagc 69540ttataggagg caccctataa atgtttaatg aatgtttgaa
tgcaaaagtg tatctaactt 69600tcttaatgat atatttatga aaagaacttg ctgagaaaaa
ggtcagttag aaagggttag 69660gaacttgtca gtattctaaa tccctctttt tcaaaagcat
acacatttag gaatgactgc 69720cttgctttaa gaatttgtag ggttttgttc acctgagttg
taccttgctg tcacagaagg 69780atgccctgca gtggtctcgc catccagcta cagtggaggg
agaggagcca gaggacacgg 69840ctgatgtgga gagctgtggg tctaatgaag ccagcactgt
gagtggtgaa aacgatggta 69900aggacccttt aatggatggg tgagggagcc acagcaggca
ctagggacta acctttattt 69960tcctctcttc cagtatctct tgatgaaaca tcttcgaacg
catcctgttc tacagaatct 70020cagagtcgac ctctttccaa tcccagggac agctacagag
cttcctcaca ggtaaggaag 70080aggtagagcc tagcctggga ggatgaatga tgacaggtat
aaggcaagat ccctccttct 70140cctgtagtga gctgtgaaca tgttcagaga gtgaagaata
gaagtctggt ctccagctgt 70200tagtagcatt taacaggggg ccgcaggaaa agtgaacagt
aggtttgagc agagtaagtt 70260ttttctcttt ctttaccttg gctgagtgat tttgttcatt
cttttttttt tttttttttt 70320ttttttttga gatggagtcg cgcctgtcgc tcaggctgga
gtgcagtggc atgatctccg 70380cttactgcaa cctctgcctc tggggttcaa gcaattctcc
tgcctcagcc tcccgagtag 70440ctgggattac aggcacgtac caccgtgcct ggctaatatt
tgtattttta gtagagatag 70500ggttttgcca tgttggccag gctagtctcg aattcctgac
ctcaagtggt ctgtccacct 70560cagcctccca aagtgctggg attacaggtg tgagtcacca
tgcctagcct gattctgttc 70620attcttgtaa tatacacgtg aacattcagg gagaagtgtg
gttagtgcag agtagagaga 70680acaggagatt gggagtgagc agtttgaatg ataaccctgc
acttactagc cttgagactt 70740ggggaaaatt ccttacctgt aaaatgggga taacagtaca
tttttgtagc ttggaatgat 70800gcttggcaca gtgaccagca cgtagctcag taacattaac
cagtgctctt gtcagcatta 70860tttgacagat ctggttgaag acgaacttca ttttacaaga
gcgtgagtag agatagtgtc 70920gccagggaat gcttttgtgg ctctgcagtt gacttgggct
ctcttttgtt ctctcttgga 70980acgcaggcga acaaacaaaa gaaaaagact ggggtgatgc
tgcctcgagt tgtcctgact 71040cctctgaagg taaacggggc ccacgtggaa tctgcatcag
gtatgtgtaa actcatggtt 71100gtgatgcttt ttcctcaggt cctggggacc tggcctccct
ctgtcagcag tttctgacct 71160aatagtgcga tactaggaga gctgtcgggc cacaggcaag
agccctgcca atggatgagg 71220cctgccatag gttctagtgc tgggctctgc tgtgtgcctt
cctctttgtc tcccagggca 71280gtcgtgagga tccaacggag gatttgatta tgccagtgct
ttgtaaaagg tgtagtgcta 71340tacaaataaa gatggcagtt tggcacctgt aaggtgatat
tttaaagcca gaccatgaag 71400tggtggtttc tctcagccta aggctgggag atggaagcat
cccagtattg ctggcagcat 71460ctcagggaga gctgggagaa atgagcttgt ctgagagcca
tgggcgcggc ttggtgatac 71520ttttgaccag tggaatgctg tgccttcagg gttctcgggc
tgccacgccg atggcgagag 71580cggcagcccg tccagcagca gcagcggctc tctggccctg
ggcagcgctg ctattcgtgg 71640ccaggccgag gtcacccagg accctgcccc gctcctgaga
ggcttccgga agccagccac 71700aggtgagtgg cgtggcactt atttctctgc ctgtaaaggg
ggcccctgca ggcctagtga 71760gaagatgatg tcttctattc caattccttt accagtttat
ttttacttct tgggtggccc 71820tctatttttt gtttattttt actttgtaat ttgcttattt
catttgtagc tctctgctaa 71880actgtgagaa ctcctttcag gcagagatga tgccatactg
tttctcgtat gtccctgtag 71940gcctagtcta tgcctgcctt gtactgcata gtaagtgttt
gagtgagtga aaactgcttc 72000tgagcttctc agtgaagaat tccaacaccc cttttctctc
ttcggtagca tgttgccaca 72060tttgttccca acatctgtag tctgtatcag acgctccctt
ttttacaacc tagtcagtat 72120gttgagtgga agcatgtgtt gaattttggg gatgcaaaca
aattcagtag tgctattatc 72180tatacctccc acccctcacc ccaccccacc cccattaggg
ttatttgcaa tattagtatg 72240ctctttgcta tttcaggatt taattcttaa tgacccacat
gctggttttt tttgtagatg 72300aaaccattaa gaagacaagc ttttgcttct gagaattaga
gtaaaccttt gcccatgtga 72360gaactaggtt tgctgtcttg ctgcttttcc agctcatcag
cagtgctcaa tctaaggtct 72420cacaggtctc tagtcctagt gagtttttca gataaaagta
acatttgctg aggcttctgt 72480gagaggtatt agcatctcag ttggctttga acagtcctta
gtacatttct gcatggagat 72540catccctctc cagcccattc acagaaggct tctgcagatt
tttctatagt atactaacta 72600gatttacttt tagataattc tcatgatttc tccagttgag
ctttgtggag cctgttctcc 72660agctttggag ggaagctcag aacctgcccc ttgcctgatt
ttctgtggga agtgtccttt 72720tcaggctgtg acacagcacg gtacagagtt ttgtctgagg
agatgcaacc ccaagtgttc 72780tcctgggttt gatggcaatg acagtaacct ggaaagaata
tacaggttag gatggactgg 72840acaattgagc agattgtgtg cagataactc ctgggtagct
tgggtgctgt caccaaagtt 72900ttcccatcag ttggcatttg ttttttcttt taaaaagctg
aaatctatac cttgcttcaa 72960aaatcatagg tcaaatgaag cgcaacagag gggaagaaat
agattttgag acacctgggt 73020ccattcttgt caacaccaac ctccgtgccc tgatcaactc
tcggaccttc catgccttac 73080catcacactt ccagcagcag ctcctcttcc tcctgcctga
agtagacaga caggtgcaca 73140tgggcagcct cccctttgcc tctctctggg tgggcttctg
ttctctttta agtttattta 73200ttaggatttt tttccccctt gatccttcta ggtggggacg
gatggcctgt tgcgtctcag 73260cagcagtgca ctaaataacg agttttttac ccatgcggct
cagagctggc gggagcgcct 73320ggctgatggt atgtagactt ggtcatctcg gacggcttgc
gacgcacctg tcgtgtggtg 73380ttgcatgtct cctggtattt aaaacccaag ctcgctcttc
tcaaagggtt atttagtata 73440agacaggctt tcctcattac taataaatgt ggtgggtatt
aatatgccac acagctctga 73500agaaataaca gggtgtttag gtttagactt tcactatatt
gtatgtatgt actcattcat 73560catctccttt ttatcattaa aactataaac acctattcca
gtaatcatgg catggtctgg 73620aagggtggag gaaagtacac tgtggagttg agaagctcca
ccatgctctg tctttttagg 73680cattgtcact tggagtgatt gttagcttct attaatttaa
ttttgtgggg aaagtgttga 73740gagggctcta agaacacccc taggtttgat gatttgctag
caggactcag catatagtta 73800tatgtacagg gctgcggttt attacagcag aagaatacaa
agtaaaatca gcagatggag 73860aggcacatgg ggtggggtcc aggggaaacc atgtgttggc
ttccaaggtc ctctctcagt 73920ggtgtcacac aggacacatt taattccccc agtaacaagt
tatgataaca tgtatgaaat 73980gtctactagg gaaacctgtt aaagactcgg tgcccagggt
ttttatcaag ggctgatcat 74040gtaggaagcc actgcttggc acatacccag cttccagatt
cccaaaagga aggcaggtgt 74100tcagcataag ccgtattgtt tgcataaaca atttaggcac
agtgaacaac tcatatcagt 74160tagggtggtt gggaaccctc ctgaaatcta agttcccaga
tgtcagccaa gggctgttct 74220tttaagtagg cctttctaag agtaaacaat caggcctacc
tactatgtta actttttatc 74280tacacaggaa atatgaatgg ttcttttgtt tgttgttttg
ctttttcgat caaggagttg 74340cttggtctca ctttaaggaa gagtgaattt cccttatagt
agatgtgtta gctctgtccc 74400tataagagca tgatgtgaga gagcctttag aagagacgtg
ttgttttaaa actgggagat 74460tcagctgtcc ataagacaga cattaatatc ccgaatgcac
ttactagaag aggtttattt 74520ctccctaggt gaatttactc atgagatgca agtcaggata
cgacaggaaa tggagaagga 74580aaagaaggtg gaacaatgga aagaaaagtt ctttgaagac
tactatggac agaagtaagg 74640cagttggagc tatgagtcct ggtctggggt tttgagggga
tagaggtaga tggtctcaaa 74700atagcatata cttatgtgtt ggacaagaat gtggagattg
cagtgacact tgggtcattt 74760atcttaatgc cattcatagt gaagctaaca gaagtttttc
catggttaga ttgtgcacca 74820cacagattta ttttgttctg agatatctgt gtttctgggt
ccatattatt catagaaata 74880agagacatgt ccactctggc ctgaaactga tggctgtgat
tttgatttgc aggctgggtt 74940tgaccaaaga agagtcattg cagcagaacg tgggccagga
ggaggctgaa atcaaaagtg 75000gcttgtgtgt cccaggagaa tcagtgcgta tacagcgtgg
tccagccacc cgacagcgag 75060atgggcattt taagaaacgc tctcggccag atctccgaac
cagagccaga aggaatctgt 75120acaaaaaaca ggagtcagaa caagcagggg ttgctaagga
tgcaaaatct gtggcctcag 75180atgttcccct ctacaaggat ggggaggcta agactgaccc
agcagggctg agcagtcccc 75240atctgccagg cacatcctct gcagcacccg acctggaggg
tcccgaattc ccagttgagt 75300ctgtggcttc tcggatccag gctgagccag acaacttggc
acgtgcctct gcatctccag 75360acagaattcc tagcctgcct caggaaactg tggatcagga
acccaaggat cagaagagga 75420aatcctttga gcaggcggcc tctgcatcct ttcccgaaaa
gaagccccgg cttgaagatc 75480gtcagtcctt tcgtaacaca attgaaagtg ttcacaccga
aaagccacag cccactaaag 75540aggagcccaa agtcccgccc atccgggtag gagactgttt
gattcctggc tgccctggag 75600ccaggttttc tttgagggtc atgagattat agagccctta
actctggggc cctgaagtta 75660attatgtggg aatgtagagc tttttatgag aggtttgctt
gagacagcct tcaagtttag 75720tgagataggt tcttttcttc ctcacttttt tgttcactct
gttgaagtta tcttgagagg 75780tcaaaatcct ttggggtttt aaaatctttt taagatagca
ttagattctt tgctatagtg 75840actcacacag tcccaccaga aattaaattt agaagtgtgg
catataacag cccttgagca 75900gaatcttctc tgaatggtgt gttatggcgc cattttacta
tgatgatttc attgttttaa 75960ggaaattatt tgattctgta tgccatgacc cttaagctac
tagaatccta gttttgcttt 76020acagtcccta ggtcagatca cccagtcagt taaaactatt
ttctaattct ttttttgcag 76080attcaacttt cacgtatcaa accaccctgg gtggttaaag
gtcagcccac ttaccagata 76140tgcccccgga tcatccccac cacggagtcc tcctgccggg
gttggactgg cgccaggacc 76200ctcgcagaca ttaaagcccg tgctctgcag gtccgagggg
cgagaggtca ccactgccat 76260agagaggcgg ccaccactgc catcggaggg gggggtggcc
cgggtggagg tggcggcggg 76320gccaccgatg agggaggtgg cagaggcagc agcagtggtg
atggtggtga ggcctgtggc 76380caccctgagc ccaggggagg cccgagcacc cctggaaagt
gtacgtcaga tctacagcga 76440acacaactac tgccgcctta tcctctaaat ggggagcata
cccaggccgg aactgccatg 76500tccagagcta ggagagagga cctgccttct ctgagaaagg
aggaaagctg cctactacag 76560agggctacag ttggactcac agatgggcta ggagatgcct
cccaactccc cgttgctccc 76620actggggacc agccatgcca ggccttgccc ctactgtcct
cccaaacctc agtagctgag 76680agattagtgg agcagcctca gttgcatccg gatgttagaa
ctgaatgtga gtctggcacc 76740acttcctggg aaagtgatga tgaggagcaa ggacccaccg
ttcctgcaga caatggtccc 76800attccgtctc tagtgggaga tgatacatta gagaaaggaa
ctggccaagc tcttgacagt 76860catcccacta tgaaggatcc tgtaaatgtg acccccagtt
ccacacctga atcctcaccg 76920actgattgcc tgcagaacag agcatttgat gacgaattag
ggcttggtgg ctcatgccct 76980cctatgaggg aaagtgatac tagacaagaa aacttgaaaa
ccaaggctct cgtttctaac 77040agttctttgc attggatacc catcccatcg aatgatgagg
tagtgaaaca gcccaaacca 77100gaatccagag aacacatacc atctgttgag ccccaggttg
gagaggagtg ggagaaagct 77160gctcccaccc ctcctgcatt gcctggggat ttgacagctg
aggagggtct agatcctctt 77220gacagcctta cttcactctg gactgtgcca tctcgaggag
gcagtgacag caatggcagt 77280tactgtcaac aggtggacat tgaaaagctg aaaatcaacg
gagactctga agcactgagt 77340cctcacggtg agtccacgga tacagcctct gactttgaag
gtcacctcac ggaggacagc 77400agtgaggctg acactagaga agctgcagtg acaaagggat
cttcggtgga caaggatgag 77460aaacccaatt ggaaccaatc tgccccactg tccaaggtga
atggtgacat gcgtctggtt 77520acaaggacag atgggatggt tgctcctcag agctgggtgt
ctcgagtatg tgcggtccgc 77580caaaagatcc cagattccct actgctggcc agtactgagt
accagccaag agccgtgtgc 77640ctgtccatgc ctgggtcctc agtggaggcc actaacccac
ttgtgatgca gttgctgcag 77700ggtagcttgc ccctagagaa ggttcttcca ccagcccacg
atgacagcat gtcagaatcc 77760ccacaagtac cacttacaaa agaccagagc catggctcgc
tacgcatggg atctttacat 77820ggtcttggaa aaaacagtgg catggttgat ggaagcagcc
ccagttcttt aagggctttg 77880aaggagcctc ttctgccaga tagctgtgaa acaggcactg
gtcttgccag gattgaggcc 77940acccaggctc ctggagcacc ccaaaagaat tgcaaggcag
tcccaagttt tgactccctc 78000catccagtga caaatcccat tacatcctct aggaaactgg
aagaaatgga ttccaaagag 78060cagttctctt cctttagttg tgaagatcag aaggaagtcc
gtgctatgtc acaggacagt 78120aattcaaatg ctgctccagg aaagagccca ggagatctta
ctacctcgag aacacctcgt 78180ttctcatctc caaatgtgat ctcctttggt ccagagcaga
caggtcgggc cctgggtgat 78240cagagcaatg ttacaggcca agggaagaag ctttttggct
ctgggaatgt ggctgcaacc 78300cttcagcgcc ccaggcctgc ggacccgatg cctcttcctg
ctgagatccc tccagttttt 78360cccagtggga agttgggacc aagcacaaac tccatgtctg
gtggggtaca gactccaagg 78420gaagactggg ctccaaagcc acatgccttt gttggcagcg
tcaagaatga gaagactttt 78480gtggggggtc ctcttaaggc aaatgccgag aacaggaaag
ctactgggca tagtcccctg 78540gaactggtgg gtcacttgga agggatgccc tttgtcatgg
acttgccctt ctggaaatta 78600ccccgagagc cagggaaggg gctcagtgag cctctggagc
cttcttctct cccctcccaa 78660ctcagcatca agcaggcatt ttatgggaag ctttctaaac
tccaactgag ttccaccagc 78720tttaattatt cctctagctc tcccaccttt cccaaaggcc
ttgctggaag tgtggtgcag 78780ctgagccaca aagcaaactt tggtgcgagc cacagtgcat
cactttcctt gcaaatgttc 78840actgacagca gcacggtgga aagcatctcg ctccagtgtg
cgtgcagcct gaaagccatg 78900atcatgtgcc aaggctgcgg tgcgttctgt cacgatgact
gtattggacc ctcaaagctc 78960tgtgtattgt gccttgtggt gagataataa attatggcca
tgggaaacat tgtatattta 79020gtgtgtgtat tttgataatg attgatctta aatctgtata
cagaatatca ttgatataat 79080actctttagg caggagcact cttgccttcc cccaaaattt
acactgctaa agccctctgt 79140cacttggcga cccttctggt cttgctggag gggtttcctg
ggtataaccc attgggctgc 79200ccaaggccag ccagcctgag ctctcctgca agacagagcc
tgatgtggca cggagtgggg 79260ttgcgggggg tggggggact gcctgactcc cagagggact
tgaaactgaa gcaagaaggt 79320tgcattctcc accaagggag ttaacctacc tgaactaagt
agaaatgcca gtcttccact 79380accccctccc tgccatcttt tcttctgcta ctttggggag
ttgatggcca ggaaagaagc 79440cagcacaggg ttaaagtaac tcctggcatt gcccaccagg
gggctggtgc acctgctgac 79500ctcagggtca cagttgagtc atttgccagt tgacggagca
agtttgacct tggttctgtt 79560gctgaagcaa atttggaact tttctgtctc agtgtgatcc
actaacccac aggatcattt 79620ggaaccttga atagctctgc ttggacaatg gggttgggga
atagggttgt ctttcctatg 79680aaaatgccat ctgtagacct tgtgagtcag ccgtccagat
gtttgcaggt gaattcctct 79740gcttgacatc ctccctgtca ctttggaccc tatgggagtg
ggcatctcca cgcacctgtg 79800tatgtgaaag tcattttaca tttcaaagca gtgtgtgttt
cttattttta tatttttaac 79860tctttattct tggatgtata aagtgaactt tttggcttct
gtaagtatgc tctatgcacc 79920tctaatgttt tatcatgtat ttatatgttg tacacagtac
tggctgattc tgtaaatgga 79980tgtattgtac agagaacatg aacgtctctt cctaatttta
catcttcagc atcattgcat 80040taaagtggtg taatctcctt ctctacatct gttgtcagag
ccactgagtg ctgtgctgct 80100cgacgtgagg gtgaaatgat tgacttgtga cctgccaggt
tgcccgatgc cctgttgggt 80160caccggctgg acctgctgca gcctgcagag ccacagtcag
cctgcccaca tgccaccgag 80220caaacgcatc ttgcttttca catctctcct cctacagcct
taatggctgc ttgctgccat 80280atgtgacaaa tcaccaccac cagtgttaag tgcttctgga
ttcatgggtg agttccctgg 80340gcagccccca ggaaggcctt ccagatctgg ctccagggtc
accacctgtc acagcaatac 80400ctgggaccat gctctcctgg gactgtgagg ctccttttga
cgtacttttg acatcaggca 80460ggtttgggaa gaaacaaagc catgcctgct cctgcctctc
tcccaacatg tttccagcaa 80520gtagatgccc ctgtgtgtgt tttcccttgc cttgtttcct
gccttatatc ttgtatttcg 80580acttattaca gagttgaggg ttcttgctta atttagatca
agtataaaat ttgtatgact 80640tcaagtctca ttttatctga aaggtttttt tctcatttaa
tctgatgtgg cattttcgtc 80700atctgaagca tgagtgacaa gttgggaatg atgtggtgat
ttagaatgca gtattggcca 80760agtccaagtt gtcaacttaa gcgtctgttt accaaagacc
gggaacaggg gcccaaacat 80820gtccagtcct cttcttccct ctgctggaac ctttggggac
actcaagggt acagtttgac 80880actgatctgg tccatgaggc tgcccagaga aagcactgct
tctgtatgtc tcttgtggta 80940ttggaacaat aaacccgtac aacctgca
80968676894DNAArtificial sequencesynthetic sequence
6tccggtcgcg tccgacaccc ggtgggactc agaaggcagt ggagccccgg cggcggcggc
60ggcggcgcgc gggggcgacg cgcgggaaca acgcgagtcg gcgcgcggga cgaaggtaac
120gcgccgctgc gggcggcccg gccggcgggg ctccgggagt gcgaaccggg cggcggcggc
180ggcgccagga cctccccgcc actgctgtgc cggtcccggg tatcgccgag cggggctcac
240cggggcgccg cgtttgtagg cgtgcggggg gtggagggtg aggggagagc ccccctcccc
300ggaaggagct gtgagcttcg ggctggcccg cgggaccctg cgagtgaggc agcgcacacc
360cctggagctg cggggcgggg ggcgtgtggg gggctccttt cccggtgctt gtcctggccg
420gggcgccggg gccggggtcg gggcgttccg gtgcccggtc cagggtggca gctcgagcct
480caagtctcct ttgtgtggcg cggccgcggc gggagcgccc gggtgggacg ggacagacac
540aagttggtgg gacccagccg ccgagtccgc actcagacaa aggacggact gtgtctccgg
600agggctcggc gcgaggggaa ggggcatgac acccgggccc gccggcgggc gggagagggg
660cgtggggagg cgcgggccgc tgccggggtg ggcagggctc ggccctcgcc tcgcgcacgc
720ccccggtccc gggcgcgccg accccgggct ggggccgcgg cgctcgcggg acgacgttcg
780cggcggggaa ctcggagtag cttcgcctct gacgtttccc cacgacgcac cccgaaatcc
840ccctgagctc cggcggtcgc gggctgccct cgccgcctgg tctggcttta tgctaagttt
900gagggaagag tcgagctgct ctgctctcta ttgattgtgt ttctggaggg cgtcctgttg
960aattcccact tcattgtgta catccccttc cgttcccccc aaaaatctgt gccacagggt
1020tactttttga aagcgggagg aatcgagaag cacgatcttt tggaaaactt ggtgaacgcc
1080tagtgagttg ccactttcta aagaatcgta atccttaaac attacaagct gttttggcca
1140acttgtgtga tacatctgag aatggcgaca ggtgctaacg aaatcaactg tcattcagcc
1200agattattcc ccaaatcccg acgggttgaa tgaggatgag gtggtagaag taggtgatca
1260aaatagaatg gctatgacaa atgtgtgttt agattatacg gttagcagtt tcttattaat
1320tggtctcgtt ttctgtgaac aatagctttg gtgattcaga aaagactgca tggagaaatg
1380tttgttgcct aagaaattta acgtgtgctg tccacagtta aacttccttt atcacacagg
1440atctgtaaca tttaaattca tttggaaata aaaatgtgtc tttgctattt acttaaaggc
1500ttgcttttta gggttcaagc aagttattat tagtttaatt ttgtggcgtt ttgatgtcat
1560cataaaacag catttaataa acctttgaaa aacacgaatg ctgtcacaat tgaatgtagt
1620ttatactttt aggggttttg gagtttattt tctattactc ttcataagca ttagcaacta
1680attcatgttt aggaatactg tacaagtgtg taatcctaac ttgtttattt gtaattttat
1740ttgcaggaaa acaagtattt aagatatatt ttaattttct attcatggtc tctaaagtta
1800ggaataggta ggattctagt catagatata aagcgtcttg ttctctcttt tcggaggtgt
1860gttgggtgat gtaatattta aggtttcccg gaaacaggaa cactgcatct taaattctcg
1920tttttgtgga aagtgaatat attccaagaa aacaagttag aaaaacatag gcgttcttct
1980ggttgcactg tcctatatga taaagatcta atgtgcatct gctaacttaa ggtttcataa
2040aaatggagac aaataaatgc aatataaatt tattacatat attttggaga gtgttgacac
2100cactgtacgg gcattccagg tgctggtcta agtgttgaga cattataaca aaaaagtaac
2160gtttatatta gttactatta attctgtatt taaaaaatcc tattaataat cttgtccatt
2220atgagataag gtagttatgc agatttttgg cagaaattcg gatattttag gatacatatg
2280tgtgtgtgtg tgtgtgtgtg tgtgtgcgcg cgcgtgtgtg tgtgtgtata tgtttttttt
2340tttttgagac agagccttgc tctgtcgtcc aggctggagt gcagtggctg gatctgggct
2400cactacaatc tctgcctccc gggtttaagg aattcccctg cctcagcctc ccgagtagct
2460ggaactacag gcacgcacca cgacacccgg ctaatttttg tatttttagc agagacaggg
2520tttcaccatg ttggccaggc tggtctcgaa ctcctgacct gaagtgatgt acccgcctcc
2580gcctcccaaa atgctgatcc agacgtgagc caccacgccc agcctaggat aaaaatttct
2640aactttgccc ttgagtgttc tctgtatttg ataattacta ttctttgtac ttgccatgag
2700atattttgaa aaacatctct ttggggaatt ggtttaaaaa ttcatattaa attattttct
2760ggtacaattg agaatgtatt tagtcagttt aagtagcagt gacttaaaac acacttgttg
2820atctagtgta gttagaaaaa gttctgatac tttgatacct agctttgcct tgcacaaata
2880catttaagtg aatatcttta tgttggccat ttaaaaattt taggcaaatt tctccaagtc
2940atactggaat tttcccagga taccttcctt cttttgaggt agtgtgctca aggattctga
3000atttatttca gtattaccct ttacatgagc agtgattgag aaagttgatc tgctttttaa
3060aaaccaacaa ggacaaatcc tccaatataa tgtattctgt ggttaattag caatgattta
3120tggattagcc ttgaagtctt tatatcagta tagatgacaa attttctgta aatcatgata
3180gattctatat gagtaggtga aatcttcggg ggagagcata agtgaacagc agcaattcat
3240taaattcaga gaaaggttca tggtcagatg atacatactt taccttctgg aggtcttccc
3300tgaattccca ctcttgtgtt cccacagggt tttatcatat tttattgtag catgactcaa
3360ttgtattgta atcacttgtt tatgcatccc tctcttccct acagtcaaag tgcctcctgg
3420tagaggctct gtcttatttt tttctttgta tacctagtac ctacgttggt atttgctaga
3480gaataggggt tttaaatata gttgaatgaa ttaaggaaat atgaaaaatg tagggaaata
3540atttgacaaa ggaacttgca aagtgaacag gatatgttag tattcatgtg aggaactttg
3600aaatgtgttt ttctccctct ttaataggga atgattacaa agaaaaatag ttgtcaaggt
3660gaacaagttc caagtttttc ctagttataa tctgtagtac taaacattag atatccttta
3720gatgcaacta ttacactcgg acaactggag agaacttgat gaatcatctg gatatttagt
3780aatagtattt gcttaatttg atttaatgtt gatattgatg atctctttgc aaaaatataa
3840ggaagggaaa gggcgagaga gggtagtaga tcttttaact gaaaagctgt tttgttataa
3900ttcatgagtt ctttattgga gtaaattgag gtaggttttg gagctaaaac tgaaggatgt
3960agcgacagtg taattggatc atttattggg atgcttttca tcattctttt aaaatgattt
4020aaatacagat tagcaaattt agtgatacct caaaagttac agctggtaaa tttctaagat
4080agttgcacca ttccatatct tgccactgtt ccactacttg gtataaaaat atgacaaatt
4140tgtgtttaga ttatgtggtt agcagtttct taataattgg tcttgttttc cattaacaat
4200agcaagacag aacaagatca tagctcactg catccttaaa ctcctgggct caagggatcc
4260tcctgtctca gcctcctgag taactggtat taccagtgca caccattgtg gtgacttatt
4320taatttttta attttttgta gagatgggat cctgctttgt tgcccacgtt gatctcaaac
4380tcctggctcc aggcaatcct cctgccttgg cctcttaaag tacagggatg acaggctgag
4440ccattgtgtt tgacccagat actttttttt tttgagacgg agtctcgaaa gtgattcttg
4500tgcctcagcc tcctgagtag ctgggactac aagcgtgcgc caccacgctc ggctaattta
4560tttatttatt atttattatt tatttttttg agatgcagtg tcactctgtc acctagactg
4620gagtgcagtg gcaccatctt ggctcactgc aacctccacc tcctgggttc aaatgattct
4680cctgcctcac ctctcaagta gttgggatta caggcatgca ccaccaggcc tggctaattt
4740ttgtattttt agtagtgatg ggatttcacc atgttggcca ggctggtctc gaactcccga
4800cctcaggtga tccacctgcc ctggcctccc aaagtactag gattacaggc gtcagtcact
4860gtgcccagcc tccgataatt tttatatttt agtagaaact gggtttcact gtgttggcca
4920ggctggtctg gaactcctga cctcaagtga ttgacctgcc tcgtcctccc aaagtggtgg
4980gattataggt gtgagccacc acaccctgct gtgttgtttt tgtttttgtt ttttgttttt
5040gtttttgttt tttgatatgg agtctcacac ttgttgccca ggctggagtg cagtggcgtg
5100atctcggctc actgcaacct ctgcctcctg ggttcaagcg attctcctac ctcagcctcc
5160cgagtagctg ggattacggg aacgcaccac cacacctggc taatttttgt atttttagtt
5220gagatggggt ttcaccacgt tggccaagct agtctcgaac tgctgacctc agatgatccg
5280cctgcctcgg cctcccaaag tgctgggatt acaggcgtga gctactgcgc acgcctggcc
5340tggatacttt ttaaacattt ttaaattaaa aatttttttt tggagacagg gtcttgttgt
5400cacccaggct ggagtgcaga tgcgtgatct cagttcactg caacctctgc ctcctgggct
5460caagcgatcc ttccatctca gcctcccaag tagctgggac tacaagtgca tgccaccacg
5520cctggctaat ttttgtattt tttgtagaga cagggttttg ccatgttgcc caggctggtc
5580ttgaactcct gaactcaaga gatccaccta cctcagcctc ccaaagtgct gggattatag
5640gtgtgaccca ctgcacccag cttttgtttt taatatttgt aagaaccacc ttgtgtctgc
5700caacaggcga attaacaaaa tgtggtatat aaaccaatga aaacataaaa ggagtgaaat
5760aaagacgtaa aaggagtgaa atttcaaaat aaaagtaaaa agatttcaaa ataattcaga
5820cataaaagga gtgaaattct gatacatgga tggagctgga gaatattatg cttagtgaaa
5880taagccagat acaacctttt gtacaaaaat acaaaattgt atgatctcat ttatatgagg
5940tagttagaag aggcaactct atggagacag aaagtagaat agaggttacc agggctgtga
6000ggggagaggt gaatggggag tttaatgaat acagagtttc tgtttggaat ggtgaaaaaa
6060ttctggagat ggataatagt gatggttgaa caatattttg aatatattta atgccacaga
6120attgtacact taaaaatggt taaaatggta aattttacac gatatgtatc tgtatctata
6180tatatctctc tctatatcta tatatcttac cagaatacaa aatttaataa cacactccga
6240aaacctttac agatgaggaa actgaagaaa actgtctaca ggggaggagt taagaatttg
6300cccaggatta ttcagctggg aatttgcatt cgggatccaa acttagttct gtttcactac
6360atattatcta ctccatatta tctgttctgt gttatctgct ggctttctgg gtgattaaag
6420atatgtcagc tccgagaaga atgagtttat ttgaatcatt cagaaagtta catttaaaag
6480taggtaattg tagtttgatg gaaggtacag tgtgaaaccc tagacagact aaaggttaac
6540tttgaggatt tctttctcag ccagagtggt aatagtatgc atttgagagg ggaggagagt
6600agagttctaa ggatgtggtc tttggagaca gtttcttggg ttccagtccc tgagctacca
6660atttgtgtct ggggtgttat cctcttgatg tcttagcatc cctatctgta aattggtgag
6720gataatgata acatctgata aggtggttgt gaggattaaa ggaattgata catgtgaaat
6780ccttagaact gtacctggca aaaagtgttt gataaatgat tttcagttat tgtgccaata
6840ttattttaga gttgatgtac tttctcatta atggaaccaa acacttctca agttaaaatt
6900acgtgcttag gactggtaag ttacaaaaat ggtaccacac gttttatcta tttcaattta
6960gaaatgtctg ttgattaaat gtgttcgctt taaactactg aaacaatgta gacatttata
7020aaatgaaagc gtattgatcc ctgttatctc attcgctacc tttaacggtt tggtgtatat
7080tcttccccaa attttcaaat atattcatat atgaatatgt atttttacat acattttata
7140aaaatgggac caagttattt ggttctaaca tggctttttt ttaaggtcaa tacaaagatc
7200tgttttatta aaaaataatt gatattcctt tagggctcac tatatgcttg gtactcttct
7260aagtcattat tttatataga tactataata tcgagagatg gagagattaa gtaacaacta
7320gttagtggta gaggaaggat tttaatttgg gtacgttagc ttcaaagtcc tgatctccca
7380gccagggatc atttttggta aggcctgtga gctggaaacg ttaacacttt taaaagagtt
7440gtaaaacaat accaccccac ttccctgaag aacatataag ggagactaga taccgcctgc
7500caagcctaaa atacttacca tgtggccctt tacagagaaa gtttgctgcc ccttgctcta
7560agccatccag ctgtacctct ttggtgtaag gggggtgcat agtattccag tttatgaatg
7620tgcattacgc agcaaaccaa tctgttgtga ttgacattgt tttctctcct gaaaagaagt
7680gaacatcctt atgtatcttt gaacatttgt gtgacaattt tctatagagt tggctctttc
7740aagattatga acatttctag ttttaatagg tgttgtcaag ttatattaat ttttagttaa
7800aacaacaact gtattgaagt ataatttaca tacaataaaa agcacacatt tgaagggtat
7860gatttgagga gttttgacaa atgtatgcac ctgcaccgct gcctggatca agatctataa
7920tggttgccat catctcagag tcctttcatc ctcttttaca gtcattctct caactttttt
7980ttttttccct ccaagatgga gtcttgctct gtcacccagg ctggagtgca atggcatgat
8040ctcggctcac tgcaacctcc gcctcctggg ttcaagcaat tctcctgcct cagtctcccg
8100agtagctggg attacaggcg tctgccacca cacccagcta atttttgtag ttttaggcga
8160gatctcagct cactgcaacc ttgacctcct gggctcaatc gaacctctca cctcagcctc
8220ccaagtagct aggaccacag gcatgtacca ccatgcccag ctaacattta ttattaatat
8280ttttttgtag agatggggtt ttcctgtgtc gcccaggatg gtttccaact cctgggctca
8340aatgattctg ccttggcctc ccaaagtgtt gggattacag gcatgagccg cggcacctga
8400cttgtagtaa actctctgaa ttaatattcc attgtaggca tgtgctacag tttttaaatt
8460catttaccca tggatggaca cataggactg ttgtcagctg ttgataaagc tgctatcacc
8520atttgtatgt ctttcctgga catgttttag tggtaaatat tgattttact ttgtaagaaa
8580ccgttaaact cttttccaaa atagttgtac cattttaaat tgaaagttac agttgtaact
8640gtgcaggagt tacagtttct tcacattttc attgacactt cgtgttgcca gtcttttaaa
8700ttttggccat caaatgagta ttaagtatct cattgtgggt ttgtgtttct cagatgatca
8760atgatgttgg aacatctttt catatgctta ttggccattt gtgtactttt tttggttcaa
8820gccttttgtc cctttaaaaa attggattgt ttgtctggtt gagtggcaag aggtctttat
8880atgttctggg tacatagtca cattatctgt cagattgtgt tgcaaatatt ttattgttca
8940tttttgtttg attttgtgta tttttaatac tataaagatc aagttaaaac tttaatatgg
9000gaagcataat cagataaatt atgtgaaaca aattgtcctt aattcacgag tcatttaatt
9060agtgtaacaa aatgttatgc atttgcagaa acttgtaaac taaaaggata ttattcatat
9120gctgttaggt gtatggatga taattttttt taattaaact agttttgaaa attattgtat
9180ttagtaattc tcttcatttt gcataattca aaccttttca tttattagtg agttaagcct
9240taaatttttt cttcaaagga taaatgagaa tattaaaagt aaaaagtgac cttgatctta
9300gaatggggta tgtagaaatg atgattgcca aacttagttt ccctactttg acaatcaagt
9360aaaatttttt tttttttttt ttgagacgga gtcttgctct gtcccccagg ctggagtgcg
9420gtggcgcgat ctcggctcac tgcaagctct gcctcctggg ttcacgctgt tctcctgcct
9480aagcctcccg taaatttttt tattatagaa atggatggct tttcagatta tatatacttg
9540gtttctatac actattttat ttttgtaaag tagcagttct tttgctcaac acctgaattg
9600cccccacaat aaatttttag tttttcttca atattcaagt aatacataac ttttcctttt
9660cctgtttaac aaagaaaaaa atatataaag caagctgttg gacctccatt gggtgttgtt
9720taccaccact gtaggtgatc gtggcattgt ccacctcagt cttctcatgg ctgtggattc
9780aagttaagaa attcctgaag gtagcattcc aggtagtctg tagaacagcc caaactctct
9840gaattagtat tatctctgat aggtgttttt tttttctttg cttttttatt tgagacgggg
9900ttttgctctg tcacccagcc tggatttcag tggcacaatc ttggcttact gcaacctcca
9960cctcctgggc tgaaacaatc ctcccacatc agtctcctga gtagctggga ccacaggcac
10020atgccaccat gcccagctaa ttttttatat ttttgttaga gacagagttt cactatgttg
10080cccaggttgg tctcaagatt cctgagctca agcgatgttc ccatcttggc ctcccaaagt
10140gctgggatta caggcatgag ccgctgtgcc tggccctggt agttttcttc ttatatcttt
10200ctcctgttga tctcacttga ttttcttact agtctacagg aaatttcacg tggagattct
10260gtgcctgtcc tctttctgga atatcttcct tattttagca tctcaacatg ctgttcagct
10320tctggcttga aaccacccct ctcccatccc aaccaagtta agcagcttct ttcctgctta
10380gaagtaccat aacatgtgta ttaatctttt tttttttctc tctccttccc ttcattttaa
10440gctccttttt attaatctgt agggcagagc ttagaaaaag gtttttgtat attgtaagta
10500ctaataaaat atttgtgaag ttgatttggg acttgggaga cctctcttct gtaagcaact
10560caataaataa ttatttaagt accatcctca cccagtgtac tgttagctgc tgttatgata
10620ttgattactg taaaatttta aagtatatcc ttggtagact gttgatcaaa gtcagaaagc
10680ttgagaaact ctgaggcaaa aaaaaaaaaa aaaaaaaaaa atgaagagca tgaaatgatt
10740ctgcaaactg atcttacaat gatctttctt tttttttttt tttttttgag acagagtctc
10800actctgtcac ccaggctggc gtgcagtggc aggatcttgg ctcactgcag tctctgcctc
10860ccaggttcca gtgattctcc tgcttcagcc tcccaggtag ctgggattac aggcacacgc
10920cactacgccc ggctagtttt tgtattttta gtagagatgg ggtttcacta tgttggccag
10980actggtcttg aactcctgac ctcaggtgat ctgcctgcct tggccttgca aagtgctagg
11040attacaggca tgagccacca tgcccggcct ctttttttct tttttctttt cttttttgta
11100cacagtttca ctctgttgcc caggctggag tatagtggcg tgatcatagc tcactacatc
11160ctcagactcc tgggttcagg ggatcttccc atctcagcct cccaagtagc taggactata
11220gacgtgagac acgatgtctg gctaattttt tacatttttt attttttgta gagttggggt
11280cttatatgtt gcccagggtg gcctgccacc ttgtcctccc aaagctggga ttataggctt
11340gaatcagatc ccagtgatct ttatccctca gctgcattta tatgggctaa attcatacat
11400agtatatcaa gatgtcttca ggaagtttaa aaaaaaaaag gtatcaaaaa gacagtatgt
11460catgactgct ttatctattt tagtctctta gtttttgata ctaaagacta gaccggagaa
11520atgctttaac aaatcacaaa aatctaagaa aatagacagt taattatttt taaacagtgg
11580aagaatttca atcataatta aagcagcttt tgtatttttt gatgtcatag cctatagtga
11640aatttcatat attctgtttg tagatacatg agttcctacg atatgcttgc acataataga
11700actaattact atttgttgag aacctaacct gtacctaata tacatgtagt ttctaaatca
11760aacattttac tttttttaaa aattgtaaaa agcccatagt aaattaatca tgtttaccat
11820ttaaaaatgt acagttcagt agtgttaaat acattcacat tgttgcacaa cagatctcta
11880gaactttttt gtcttgcaga actgaaattc tgtacccatt gagcactaat tcccacttcc
11940ccctcccccc aaattcttgg cagccacctt tctactttct gtttccatga tttttgactg
12000ttttagatac ttacatgcat gggattaaac agtatttgcc cctttgtgat tagcttattt
12060tgcttagcat aatgtcattg aggttcttcc atgttgtagc atgtgacaga atttttttct
12120tttctgtaaa ggctgtatac tatttcgttg tatgtataga ctgcatttta aaatccattt
12180atctattggt ggacatttgg gttgcttggt gatttggtga ttcactattc atggttagcc
12240aggagtaata tgcagtaaat gttggtatac aaatatctct ttgagatcct gctttgaatt
12300cttttggata tatggttgcc cattgaacaa cacagctttg aactatgtgg atccatctat
12360aagtggattt ttttcaacca gccatagata gaaaatatac tattcggctg ggcgtggtgg
12420ctgatgcctg taatcccagc acttgggagg ctggggtggg aggatcagtt gaggccagga
12480gttcgagacc agcctggaca acatagtgag acctcatctc tacaaaaaat aaaaaagtta
12540gctaggtgtg gtggcatgcg cctgtagttt cagctactta ggaggctgag acaggaggat
12600tgcttgagcc tgggaggtcg aggctgcagt gagctgttat tcatgccatt gcactccagc
12660cagggcaaca gaacaagacc ctgctcaaaa aaaaaaaaaa agaaaataca ctatttgtgg
12720gatgtgaaac ttgtgtatag ggtgggtggg ctttttgtat atgcaggttc cataggtcag
12780atttgggggt ttgagtatga gtgaatttgg atgtatacag gtggtcctgg aaccagtctt
12840attcttcctc ttcttttttt tttttttttt tttttaatta ttcgtctttt attttttgga
12900accactcttc tgcatatgct gtgggatgac tgtatatcca gaattgtgat tgctggatca
12960tatggtagtt ctattttaat gttttgagta acctcagtac tgttttccat aatggctgca
13020cgatttttac agtcctaccc acagtgcaca aaggtttcga tgtctctgca tccttgccaa
13080cacttgttat tttctgtttc ttttggtagt ggccaacata atgggtgtga ggtgctatct
13140cattgtggtt ttgatttgca ttaacaatgt tgagtatcct tcatgtttat tcaccccaaa
13200tattttactt ttgaatttat tgaaaatcat gcattttaat tatgtaaaac tcaataccat
13260gcatcatttg ttaaatggga aaaggagaat ttgtccttat gactattata aaatattcta
13320ataaggtgaa cctttttttt ttttttcttt gagacaaggt ctcgctgtgt catccaggct
13380ggaatgcagt ggcgcagtct tggcttactg cagcctctgc ctcctgggtt caagtgattc
13440tcctgcctca gcctcctgag tagttggtat tacaggtatg caccaccaca cctggctaat
13500ttttgcattt ttatagagtc ggggtttcac catgttggcc tggctggtaa taagatgaac
13560tttatacttt tttttttttt tttgagacag agtcccactc tgtcacctag gtgcagtggc
13620acgatgatgg ctcactgcag ccttgacctc ctgggctcaa gtgatcctcc acctcagcct
13680ctcaggtatc tgggattaca ggtatgcacc accaccccta gctaattttt gtattttttt
13740gtagagatgg ggtttcgcca tgttgccccg gctggtctag aactcctagg atcaagtgat
13800ctcccacctt ggagtcccca ggtgctggga ttacaggcat gagccactgc attgggccag
13860aactttatac ttattaaaca gtatgctgat gataggaaaa aactgtgcaa tccttattca
13920taaaattctg atctaaaacg tgttatatta aaattaatta ataatgcaag caaaattggc
13980aaatttattt gtaaacccca ttttgggcta cttcgaaaat tatttatgga tcagaaaagg
14040ttgggaaata cttttctaga gtaattgagc aggccctgta gatggcagaa gtgttgcttg
14100aactggcgta gaggaagaaa gtgttgaatt gccccactta attccttaag taattttgcc
14160tctttggaga atatttgcct gaaatagaga actcaagtta tgctatgaag attctttttg
14220aaaaatagag acagggtctc acattgccca ggctggtctc aaactcgtgg gctcaagtga
14280ccctttcacc ttggcctccc agagtgcagg gattacaggc atgagccatc atgccagacc
14340aagaagatat tttggagggc tacatcccac cagtagcttg atgttgtaca aagagtggta
14400ggctctgggc gaggctctgc cattatacta gttgtatttc cttggcacgt agcttttgtg
14460gatctctcct cttcatggtg acatgaatga gatgaataaa taatggaaca acttgtgttt
14520actgagtatc taccatgtat gtgcctgcag agaggatgtc ttcattttgc agatgaagta
14580attagtaaat aacttgccta ggttccctca ggtagtgggc ccttgaagaa tgggctttta
14640tggccaagtg cattggctca cgccagtaat cccagcactt tgagcggctg aggtgggagg
14700attgcttgag cccaggagtt caagaccagc ctggacaaca aagtgaggcc ccatttctac
14760aaaaaattag ccacatgtgg tggcatttgc ctgtagtccc agctgcatgg gagagtgagg
14820tgagagggtc gcttgagccc agaaggtaga gactgcagtg agccgtgttt gcacccctgc
14880actccagcct gtgtgacaga gtgagactgt gtctccaaaa aaaaaaaaaa aaaaaaaaaa
14940ggctattgct gcctataggg tcctttttag tgcaaatact aggattctaa gcacttggtt
15000tctgttaccc aggtcaaact atttctttgg agagtttgat taccatcaca ggtgatggta
15060agattctccc tagctggcat ttaatccagt ggttatatgc atctttccca aattctttat
15120caagttggtc aattcataga acatctaatg ctgattataa gcctattatc ttgcttgtgt
15180ctctgcacta tgggcataat agcacctaaa agcttttgct ataatggact atgatgtatc
15240tgaataaatt acctttataa acaatcaaat ctaaattggc aagttcaaat ttacccaatt
15300tttcttatag aatttacctt tgcagttaaa gaaataattg ttttttacca tttgtctagt
15360atgacttgtt atttacaaat agcatgtaac tggccagctg tactatacac attttctaga
15420aaagaaaatt tcttcaaatt tcttattggg tgccttagtc ttttacccat tagggctatt
15480caaataaaga atgagatatt ctcttattct ctagaaagag acattctata ctaatggaaa
15540taccaacttt taaatctaga ctaccaaaaa aaaagtcatg tttttctacc ctagaggcta
15600tagattctta atgtcagcca ctcatcctgg ccctctcatt ttcttctttt cccatatgga
15660agttctaggg tgatatagtt tggctctgtg gccccaccca aatcacgcgt caaattgtaa
15720tccccaaagt tggaggaggg gtctggtggg aagtgattga atcatggggg cagacttttc
15780ccttgctgtt ctcctgacag tgagttctcg tgacagtgag ttctcgtgag atctggttgt
15840ttaaaattat gtagcacctg ccactttgct ctctcttccc cctgcatcag ccacgtataa
15900tgtgctggct tcccctttgc tttccactgt gatgataagt ttcctgaggc ttccccagcc
15960atgcttcctg tatagcctgc tgaactgtaa gcaaattaaa cctcttttct ttataaatta
16020cccaccctca gctctttata gcaatgtgag aatggactaa tacagaaaat atgtaccaca
16080gaagtggggc atcacaataa agatacctga aaatgtggat gcagcttttg gactgagtaa
16140tgggcacagg ttggtacagt ttggagggct cagaacaaga caggaagata agggaatgtt
16200tggaacttcc tagagacttg ttgaatggtt ttgaccaaaa tgctgatagt gatatggaca
16260gagatggcta ggctgatgaa gtctcagatg aagatgagga acttattggg gaactggagt
16320aaaagtcact cttgctatgt gttagcaaag agactggcag cattgtgctc ctgctctagg
16380gatctgttga actttaaact tgagatgttt agggtatctg gcggaagaaa tttctaaaag
16440cagcaacgtg ttcaagaagt ggcctggctg cttctaaaag cctgtgctca tttgcataag
16500caaataaatg acctgaaact ggaacttaaa tttaaaaggg aagcagaaca taaaagttta
16560gaaaatttgc agcctgccat gtggtagaaa agaaaatctc actttctggg gagaaattca
16620agctggctgc agaaatttac ataagaggac gatacatggg gtaaaatgct ttttcctccc
16680ctaaaagcct tggtattaat ctggaaatag caggaaggta actgtaggaa ttatataatg
16740ggtttccctg tgcttggtca tgtctttgta tcatttccat aggtcagtgg agactcagaa
16800aaccagtttc tctgggcttt tgataagtaa tgttatagta atcaacagat ggtaactttc
16860ggtaaaacaa attgtcttca tctgttttgt gctggtataa cggaatatct gagactgggt
16920aatttttaaa attatttatt tatttatttt tgagatggga gttttgctct ttttgcccag
16980gctggactac aatggtgcga tctcggccca ctgcaacctc cgcctcctgg gttcaagtga
17040ttctcctgcc tcagcctccc gagtagctgg gattacagtt gcctaccacc atgcctagct
17100aattttgtat ttttagtaga gacagggttt caccatgttg gccaggctgg tgttgaactc
17160ctgccctcag gttatctgcc tgcctcggct tcccaaagtg ctgggattac aggcgtgagc
17220caccacgcct ggccaagact gggtaattta taaagaatag aagttggcca ggcacagtgg
17280ctcacgtctg taatcccagc actttgggag gctgaggcgg gtggatcact tgaggttagg
17340agttcgagac cagcctggcc aacatggtga aaccccatct ctaccaaaaa ataaaaatta
17400gccgggtgcg ttgatgtgca cctgtagtct cagctacttg gaaggctgag gtgggagaat
17460cacttgaacc caggaggtgg aggttgcagt gagacagaat tacgccactg ccctctagcc
17520caggcaacag agtgagaccc tgtctcacaa aaggaataaa tatatatata tatgcatata
17580tgtatatata tatgcatata cgtacatata tatgcatata cgtatatacg tatatgtata
17640tgtatatata catatatgca tatatattat atataatata tagtgtatac aatatatgta
17700tatacgtata tatatgtata tatgtatata tatgtatata cgtatatata tgtatataca
17760catatatatg tatatacgta tatatatttt tcacagtttt gggggctggg aagtttaaga
17820tcaaggtacc tgcatctcat gaaggctttc ttactgtgtc ctcttatagc agaagataga
17880aggggcaagc tgggaataac tccctcagtc agactcttgt ataagggcat tcacaaggca
17940ggaaccgtcg tggtctaatc acctctgaaa ggccccatct cttaatactg ttacatggac
18000aacacctgag tttttgaggg acaccttcag accatagcac agatactgac aagtctcatc
18060aattattaag taaatagtac ttgaagggtt tgaaattttg tagtaccccg gcagtgtgtt
18120tatatttgtg ataaatttta agtataggaa aatcatggaa agacttactg ctcataactg
18180ccgtacctcg tttacctcta tctttcccta aactactact gttcttagca agatcatgaa
18240ctgtggggcc gacataagcc agaggagttt ctgaagagtc tgcttcagtg aggggttctg
18300ttgatagcca tagaataaag aaatggcact ttgcagacat tggtacttcc ttgaaagaac
18360tggctgtggc atatacagaa ctcaaaaatt gaaattacta gataatggtt acttggttta
18420gattgcctgg aaattatgag aggttctgta aatgctttgg gattagtagt ttgaaccacc
18480tagtccattt tatgattctg tcttcagaat atagaaggaa ttgcatctta tttggggatt
18540aggatataaa gttagtgtac aaggcaaaat agcatgtagg caaagttacc catgcagagt
18600ttgtgggaag atgccttacc acaaaccagt accttctttt taggttcaag accagcccat
18660ttttcctcta gaatgagaac agatcattgc tcttctgttg agcacagagt tgttggtttg
18720tacttaaggg caatcctgtt agaatcactc ctgagtggct aaatatcttc agtctgagag
18780acttgtccag caggttatgg gaacagcaga ttcatgtcac ctgtctcttg ctcacttagg
18840caaacgctta gtgtctggaa tggtgggtag aacccttgta tttactacca aaattgagct
18900ttctctgaca tttttgctca atgtatgtta gatttgtgta agttaaatta gatgttggct
18960tatgcgtggt ataagattta aaatagactt cttagcaaaa agaacacctg gtatcagatt
19020gacttacccc ttcattttgt ttgcttttat tcagtgaagt gttgaaataa caggtatctc
19080atgtctcatc tttgaattat aatgaatttt gtatcatagc tttagtttct ggtacttttt
19140tttttttttt tttgagacaa gtctcgctct gtcacccagg ctgaagagca gtggcgcgat
19200ctcagcttaa cgcatcctct gcctcctagg ttcaagcgat tctcctgcct cagactccca
19260aatagctgag atcacaggca cctgccacca tacccggcta atttttgtat ttttagtaga
19320gatggggttt taccgtgttg gccaggctga tctccaactc ctgacctcag gtgattcgcc
19380cgccttggcc tcccaaagtg ctaggattac aggcgtgagc cacttggccc cagcctctga
19440tacctatttt tttccgtttt tcctccaaca gtgtttctgt aaactgagta tatactcgat
19500gaaatgagaa gatttaactt ataaaatcga tttagtatag ttttcaagaa aaacttaaac
19560tttttttttc tttttttcct tttttttttt tttttgagac agtctcactg tgattgccca
19620ggctggagtg cagtggcaca atcttggctc actgcagcct tggcctcctg ggctcaggtg
19680attggttctc ccacctcagc ctccagagta tcttggacta taggcacatg ccatcacgcc
19740tggctaattt gtatttttag tagagacagg gtttcaccat attgtccagg ctggtctcaa
19800actcctggac tcaggcaatc tgcctgcctt agcctcccaa agtgctggga ttacaggtgt
19860gagccatggc ccccagctga aaactttaac ctttagatgt caattcagtt agtgagtctg
19920ttttatctgt tgttcaagca aattctttaa aacacttaaa atagttcagt tcttcagttg
19980gttgaaattt atatggccat ttcttttcta agcagtactc tcagataaac accagaatgc
20040tggtctatgg acttcagttt gaaatcaata gtttactgtc ttgctggaag gaggaaagtg
20100atcttactgt tgtggaaaat atatcactgc agaatctact cacttttgct gcaacggtca
20160agttaatgtt ttctatcatt cagctaagat tgctaaatta gtataacttt cctttgcctt
20220tgaacttttt agcactacag aaaccaggac tacaaatatg ttctttactt ttttctgtta
20280ttttccccta tcatgagact tcttgaaggc gaatgctgtt cattatgctt tctcatctgt
20340actttcatgt acatgtaatc cactgtagtg aaggcactaa aacctgttgt attttccaca
20400tttcgataga tctctcacag gatttaacac ttttggaatg ctcagtaaat tattattgac
20460tgcttgataa tacctctttg ttcctgcctt tccccaagtc cttcaacaga agtttcttct
20520agcactttgc aggtcagttg agtggactat ttgagtccct cacagtaatg agcttgtgtg
20580tttttgtcat tcttttttct ttttttgaaa aaacaataga gtcatttaag gaagcaaaaa
20640ggtccctggg tcaagatttt tattttatct tttatggtgg tagggtgagg tgtgagtatt
20700tagggagatg gttggtagga tggcgttgtc ttagggttgc aggaggatca gaagggtgac
20760tgtaactact gatgatatct tacagtggtg aaggagaaga taagtgaaaa cagaggcaat
20820ttgtttaaac gaattttagt agatattagt ctcttaattt ggcactgaca tatgacagat
20880tatttcattt aaattctgta gtttgacagg tataataaag tacccttcat taaatattct
20940tcacatatac tcttgtttgc ctttttctag ttgcaagagt ggtgatttct atgtttcatt
21000ataaatttta gaaatatata atttgaatat attgtctgtt ctaggttctc tgtgagtcaa
21060gaaaaggcag ggtattatga cttcggattc gtatgatgtc tggatatatt taaggggagc
21120agttctcaaa gtgtggcctg ggattatggg atcaaaacta ttttttcttt ctttctttct
21180tttttttttt tttttgagac agggtctcac tctgtcatcc aggctggagt gcagtggcga
21240catcttggcc cactgcaacc tctgcctccc aggttcaagt gattcttgtg tctcaacctc
21300ccagaaacta ttttcataat aatactgagt tgttccttgc ttttttttaa aaaaacaaaa
21360caaaacaaaa acaaacaaaa aaaccatgtt ggacatttgt acccacggtg caaaagcaat
21420gaataaacac tgttggcacc ttagcacttg cagttaaaaa agccagtttt gtttgagaat
21480gtccttgatg aagtactaaa aatgattaat tttattaaat cttgatcctt gcgtgcatgc
21540agttgtaaca ttctgtgcaa caagatggga atgtgtgtaa agtgcttctg ctgcatattg
21600aggtatgttg ggttttgagc aaaagcactt acgtgattaa gttgtgagct ccactagcca
21660cttttttcat ggaaatttca tttttactta aaagagggtc tgacaaacca tgattattca
21720gacttaggta tttggcagac tttttttaaa tcaatgaagt gagactgtca cttcaaggaa
21780aacaactgac catatttgtt ggcagagaga acatttgggc tttcaagcaa aaattaaaat
21840ttttggaaaa cttttgtctg ttactgtgag catgacagct tcccagtact taaagacttt
21900ctgatgagat taatgggttt aacaacatga ttttttgaaa tatgccaact tctggaaaat
21960ctgcgtaact cagtggacca gtacttttta gatgaggaat gatgatttat aacattgtgc
22020ctgagttaaa gattcattta aagtgaatag actaatgaat gttaatgtgg cagagtagga
22080aaagttcact gatacaattt cggattccat gttgcatcta atcttgtaag aaagaaatta
22140ccactgctaa ctgaagtatg gtggttattt tgaggaaaag cacctgtgag attgagttgt
22200gaactgaact agccactttt taatagaact gttttggtgt aatatcaaag cacgagatcc
22260acaatgacct cagaaggcta ttcaaacact ctcccttttc taagctaagt atgtttgaga
22320ctggattttc ttcatatact tgaaccaaaa caacatattg gaacagattg aatgcagaaa
22380cagttacgag aatccgtttc ctattagaca gatattaaag aaattggcaa aaatgtaaag
22440caccacttac taattaattt tttttttttt tttttaaata aaagaaggct atgttgctca
22500ggctggtctg aaactcctgg gctcaagtgg tcctcctgcc tcagccccgc aaagtgctag
22560gattataggc atgagcaacc acgcttgccc tcactcacta atttttttta aaggaaaata
22620agtttctttt taaaaatgtg ttatttatat taggtacagt tggccctcca tattttcagg
22680ttcagcttct gtgcattcaa caactgcaga tcaaaaatac ttgtggaaaa aagccaataa
22740aataatagaa cagggcgggc gctgtggctc atgcctgtaa tcccagcact ttgggaggcc
22800aatccgggtg gatcacctga ggtcaggagt tcgagaccag cctggccaac atggtgaaac
22860cctgtctcta ctaaaaatac aaaaattagc tgggcatggt agtgtgtgcc tgtaatccca
22920gctactcagg aggctgagac aggagaatcg cttgaaccct ggaggcggag gttgcagtga
22980gccaagattg cgccactgca ctccagcctg ggtgacagag tgagactctg tctccaaaaa
23040aaaaaaaaaa gatacaaata atacagtata acaaggattt atataacatt ttacattgta
23100ttagatgatc ataagtaatc tagagccaga tgatttaaag tataaaggag aatgtgcata
23160ggttatatgc aaatactgtg ccattttata taagagatga gcatctgtgg attttggtat
23220ccatgaagtt cctggaacca atacccccta gacccccatg gatactgagg gcttgctata
23280acagttttta ataaaaataa aaaacaggcc aggtgtagtg gctcacacct gtaatcccag
23340cactttggga ggccaaggtg aggtgattgt ttgagcccag gaattcaaga ccagcctggg
23400caacatggcg aaaccctgtc tctgctaaaa atagaaaaca atagccagac atggtagtgt
23460gcacatgtgg tcccagctac ctgggaagtt gagatgagag gatcacctaa gcccaggagg
23520gcgaggctgt agtgagccgt gattgcgcca gtgcacttca gccagggcca gagtgagacc
23580ttgtctcaaa aaaataaaat aaaataaaag taaattgtaa aaaactcttt agtttttcat
23640ttctattatg ttaaatgtta atagctataa cacatataaa ctaaacaggt catgagacca
23700aaatgctgaa gaatggtgtt aatggtgttc ttacttactt tgaattaccg tttttatttt
23760tctatgctag ctaattacta tgtgaataat taacctcaat gaagttctgt attctctgtt
23820gtagcagtgg ctgatttagg gctcagttgt cttttgacct gttcttcctt ctcatatgat
23880tgcatctcga tttttaattt tagacttagt ttttaattct aaaattaaaa atcttttttt
23940ttttttcttc tatgcccact gctgtcaacc cagtcagggc ccttatcact ttattcttga
24000attacttcag ttctccattt tttttctcat gtggtgtttt tcaaacttga gtgttgattg
24060gaatcccagg gttaattcaa ctttaatttt atgaatatga tttcatataa gttccttatg
24120ataaaaccag agcagattta caaattaaat atagaccatc aaattagctg tacatattta
24180aggatgagat tttgttaaaa ccaaatagtc aatgttagag cttatagaat ggcatagcct
24240caggatcagc tttataatca gtttttttaa atttggcttg ataatactaa cagagaatgg
24300ctatttgcat aaatatgttt tataaaatgg tgttaacttt tagtctttgt tcaggataat
24360gagacctact agttaaccag aacggggcca gcaagcaact cttgaatgct agttttaatg
24420cctgatcaaa attctgtaaa gctgtgttga tcactgaggc gttgcggata tactgagcct
24480gcattaagtg gatatttaat ctaattattt ctggaatctt taccagaaaa catgctctta
24540catagtttgc tcctgggttt gctgttggtg aactgccgtt ggttggtggg atctctgtgt
24600cccatgggct ttgccacaca gctggggctc tgagtacttc agctcacatt cctttgtttg
24660ccacccttgc cttaactcac ttacctgtat tgttttttct cccatagcac tcaacatcat
24720cttacatgta aacattttac tttgttgttg ttgttgttgt tgttgttgtt gtttttgaga
24780cagagtcttg ctctgttgcc caggctggtg cagtggcaca tcttggctca ctgaaatccc
24840tgcttcctgg gctcaagtga ttctcatgcc tcagcctcct tagtagccgg gactacaggt
24900gtgtgccacc actcctggct aatttttgta tttttagtag agacggggtt tcaccgtctt
24960ggccaggctg gtcttgaact cctggcctca ggtcatccac ctgcttcagc ctcccaaagt
25020gctgggatca caggcatgag ctactgcacc tgacactttg tttttaactg tttctgtcca
25080actagatttt aagctgtata agggcacaga tttttaattg ttaattgcta agtcttcagt
25140ttctattgta gtctctggct tgtattagat gctcaataaa tatttgttga cttaatgaat
25200gcatattaac ccttcttttc tttattcaac tgcaaactca aatactcttt tctgagttgt
25260gtgctctcac tgtgggtaaa gaccagtttt tctcttcatt ttaaacacaa ctaaactggc
25320cctgaattgt atagaatcct tttgatttgt tgtttgatca gtacaagttc agtcagtggc
25380acagttactt cccttgattc agattctgta gaagcctaaa agtgcattat ctcttcaagt
25440agacatgtca tcatataggc tgctatggag atcttttttt ttccttttaa attgtttgtg
25500taacagtttc tgttttaaaa cagtggaatt accagcctgg acactatagt gagacacttt
25560ctctacaaaa aataaattaa aaaaaattag ctgggtgtgg tggagtacac ctgtagtccc
25620cagctactcg agaggctgag gcagaaagat tgcctgagcc caggaatttg aggcttcagt
25680gagttgggat tgcatcactg cactccagcc tggacgacag agtgagacct tgtcccttcc
25740aaaaaaattg aaaaagtaga attatatttg ggagtttttt tcctcaaatt cctttgaagt
25800taagatttat aaaagtatgg gaggccaagc tgggattatc atttgggccc agatgttcca
25860ggctgcagtg agctacggtc gggccacgga actccagcct ggggaacaga gtgagccctg
25920cctcaaaata ataataaaaa taataataat agtacaagct ctcttaatta ctacctgttt
25980tttttttgag acagagtctt gctctgtcac ccaggctgga gtgcagtggc gctatctagg
26040ctcattgcaa gctctgcctc ccgggttcac gccattctcc tgcctcagcc tcccgagtag
26100ctgggactac aggtgcccgc caccacgcct ggctaatttt ttgtattttt agtagagatg
26160gggtttcacc ttgttagcaa gaatggtctc gatctcctga cctcgtgatc tgcctgcctt
26220ggcctcccaa agtgctggga ttataggcgt gagccactgc gcctggccac tacctgtttt
26280tttttttaat cctatgtttt taaataattc taatcatcta ttcatatttt ttgtttctcc
26340tatttaacat tttatgtaac atttttagat tttaaaattt gtttctgtta tcacttctaa
26400aagtgaatgt tatttttaaa aatgaatgcc tttacattgg gttgttatgt aacctaattt
26460gctttaacaa ataactttat tttggagtaa ttttattttt aattatttat ttatttattt
26520atttatttgg gacggagtct cgctctgtcg cccaggctgg aatgcagagg tgcgatctct
26580gctcactgca gcctccacct cctgggttca agcaattctc ctgccttagc ctcccaagta
26640gctgggatta caggtgctcg ccatcatgcc cagctaattt ttgtattttt agtagagact
26700gggtttcacc atattggcca ggctgctctt gaactcctga cttacgtgat ccgcctgcct
26760cagcctccca aagtgctggg attaacaagc atgagccact gcacctggcc tattttggaa
26820tacttttgga tttatatagc catggtatat ttgttaaaac taagaaatca gtatcagtat
26880gttgtcatta actaaactca agactttatt tggattttgc cagttattcc actaatgtct
26940ttctttggtt ggttggttgg ttggtttcag gatccaatcc aagataccac agttcattta
27000gttatcatgt ctcctaagtt tttctgatct gtggttgttc tcagcatttc cttatttttc
27060atgacctctt aatcgtttta aagtgtattg gtcagatgtt ttgtaagaat gtcctttgat
27120ttcggcttat cggatgtttt cttatgatta ggctgaagtt atgggttgag gtctggggga
27180aggataccac agaggtgaaa tccccatctc atttcatcac atcggggagt acataatgac
27240agcagtactt accattgctc atgttaatgg ttatggtttt ttttcacaga aacattactg
27300tttccctttc cagactcttc tttggaagtg aatcattgaa tctagctcac gctcaggggg
27360aaggaaattg aattctccct cccagaatgg ggacatacac tcatgtatca gttggaattc
27420ttgtcaggag agttgttcct tctcctccag ttgtttattt aatcacttat ttatatcata
27480gactcatgaa taattatttt attctgttat aatactgtta tgatttactc tgctgctcaa
27540attattccag ctttggccac tgagagtttc ttctgtttgc ttccagtctc ggacctatcc
27600gtctcctttc atctttggag catttccctt cttctactgg cttgccttgt agtttccctg
27660tcccaaccct agaatcagct gtttctgcag accctgcttc cttgtattta ttggaaggtg
27720gtatttagaa acaaaagtct tgggtgcagg gtatgcttat tttattgctc ctggggtgtc
27780actgcttcca ggccctctgt tggacagacc ctggaaatgc aggtatttca gctaacctgc
27840atgtgcatac atacctacgt ttctgtatct atccgcatat attttaaaat acacgtgagt
27900tcatattgat atatctgact aattcatcac cacctcttgc ttatttgtaa cttctttctg
27960tgacattgag aaacttggca cacattatct acattttatt tacttatttg tttaacccta
28020gtgtacatgt agagtatttt cagaattaca gactggtacc cttatgagaa acaaatttac
28080cagctagagt acagagtaga ttgtccaaag ttctgtagat tagctccccc cgacctcctg
28140ctccttccat gagattatct cataaaatta taatactgtt agacttgctg tatagtttgc
28200attctatcct gagatcccct gacatcctgt tttgttttta tttgcataca gtttaccatt
28260taaaaaaagt ctttatattg agttgttaac tttttaatat aaatgttgta attcctgata
28320ttactcatct gccatttatg tagttgatag tcactacttt tttttttttt tttttttttt
28380tgagatggag tcttgctctg tcgcctaggc tggagtgcag tgacgtgttc tcagctcact
28440gcaacctccg cctcctaggt tcaagcgatt ctcctgcctc agcctcctga gtagctggga
28500ttacaggcgt gcatcaccac gcccggataa tttttgtatt tttagtagag acggggtttc
28560accatgttgg gcaggctggt cttgaactct tgacctcatg atccacctgc ctcggtctcc
28620caaagtgctg ggattacagg cgggagccac agcgcccacc tgatagccac tactttttta
28680atgctgatat agtgcttacc atctgtcagg cactgtctat gcaccgtaaa taaatttact
28740tctcacaatg actctgaggt ggaggctctt gaattagcct tttttcatga ggagagtgag
28800gcacaaagat gtgcagtaac ttggccaact tcacacccag ctgctaagtg ggagaacttg
28860gatctgaacc cagggaatga gctttggagt ccaaactctt gctttttgtt taatgctgtg
28920tataggactt agaattaata caactaactc ttctcttatt agtttagttt attacttgga
28980atttggtgtg aaatagagag tgctgctacc ccaattcttt gccccatgtg tgtaacaggc
29040attattaatc atgacagcac tctctctgct gagctagaac atggcctggc ctaaggccaa
29100taatccttat ggacacaacc ctcaaagtgg ttgtatgaga tgaactctcc ttgccatctc
29160tgatcttgtc tgttttgaat cctgattcta gtgcccagtg catggcactg cgtgcctgct
29220tctcctggat tcctctctca tggtcttcct ttttacaggg acaggttttc tatattcccc
29280ctcaggcata ggatctgttt ctcttaagta attaattttt atcacttacc aataatttaa
29340catctatatg tctaagttct ctttatattg tttttcttat ccttacctac aaaatctcat
29400ttaccattga tttaaatttc agtatattga aacaatggat tgtaacatta aaaataaatg
29460aaattgccaa atgatactaa cagctgcctt caaagcattt aaacatacaa acaggcacta
29520ttgaagactg gagagttatc aaaattggca attttttggc agtcttgctg tgaagtaaac
29580atttttaaaa ggaaggacat tgagaatatt gtaatcatat tacttacatc ttgttgggtt
29640tggatttgac cttacatagc ctggtattca gttaagagtc aaagttgctg ctattaattt
29700agttgagaag gataaatagt acatgtagtt tattgttttc tttagagaaa tagaaacaga
29760aacatttatt tggccagacc aaataggtgg tcattccctt gatttagcaa atccttgagg
29820tagaattttt tttttttttt tttgagacgg agtctcactg tgtcgcccag gctggaatgc
29880agtggcacga tctcggctca ctgcaagctc tgcctcccgg gttcacgcca ttctcctgcc
29940tcagcatccc gagtagctgg gactacaggt gcccgccacc acgcctggct aattttttgt
30000atttttagta gagacggggt ttcactgtgt tagtctcgat ctcctgacct catgatctgc
30060ccatcttggc ctcccaaagt gctgggatta ttggcgtgag ccaccgcgcc tcccggtaga
30120atttttaaag aagcaataag ggctctgaca atacctatgg gacttttttc aaattattca
30180gttattggca gctgggtaaa gagggacagg aatgtctgat ttaggtaaat acctctcaca
30240agtggagtag gggcgtatct ggtagagaac agtgctgatt ccttggactt gtgtggcctg
30300gccacctgag aggtaggtag gaaggtgtgt cttggccatg tcctggggcc tctgtaaacc
30360tgagaggatg gaggaagctc tactttttct gacgatgctg ttggtgataa tgaagtaggc
30420tatgagagcc catcttccat taattcagat gttcctatac agttggccct ctgtaaatgg
30480gattctacat ttgtagattc agccaactgt gggtaaaaat acttgaaaag aaacaaaagt
30540gtgtgtactg aacatgtaca tacttttttc ttgccattat tccctaaaca taatagttta
30600acaactattt atgtaatatt tacattgtat taggtattta gtaatctaga gatggtttta
30660aagcaggggt ccctagtccc caggccgtgg actggtaccc gtctgtggcc cgttaggaac
30720tgggctgtac agcaggaggt gagctccgcc tcctgtcaga ttggcagcag cattagattc
30780tcacggaagc gtgaacccta ttgtaagctg cacacgtgag ggatctaggt tgcacactcc
30840ttaaaagaat cttttttttt tggagacgga gtctcgtctc actgtgttgc ctaggctgga
30900gtgcagtggc atgatcctgg ctcacctcaa cctctgcctc ccaggttcaa gtgattctcc
30960tgcctcagct tcctgagtag ctgggattac aggcacctgc ctccacaccc agctaatttt
31020tgtattttta gtagaaacag ggttttacca tgttggccag actggtctcg aattcctgac
31080ctcaagtgat ctgcctgcct tggcctccca aagtgctggg atatgagcca ccatgcctgg
31140ccatccttat gagaatctaa ctaatgcctg atgatctgag gtggaacagt ttcatcctga
31200aaccatgtac cctctcccct ctttgtggaa aaactgtctt ccacaaaacc agtccctggt
31260gcaaaaaagt tggagactgc tggtttaaag tatatgggag aatgtgtata cgttatgtaa
31320tagtgtacca ttttatatca gggacttgag tcttcgtgga ttttggtatc tgttgggggt
31380cctggaacta atcctccgtg gatatggagg aacaactgta tatatggtct cagtaataaa
31440tacgtatctg agataccctc tgtattaaga aaaaaaagat gggaatttct tggctcatat
31500aactgaatag ttccgaaatt tgggaaggtc tgcctgactt agggcttagg tcatgagact
31560acagttcttt cttggctttg acttttgttt tttgtagttg ttgactctgt tctttgaggc
31620tcttctccaa gatggcttcc aacaagtcct tgggcaaaca tttttccagg tttagaccta
31680aggggagaag agtgagcatt cttgtcctag cattgcagga aacctgagat tttcactgtg
31740actgcactga ttgtggccgt gtatctaacc ctgtactggt cactatgtct agggagatgt
31800accttggtca ggccagggtc acaagcagct tgagtcagct tcctccagtg tacttggtag
31860ttctcagaga agagttggtg tgaagttccc aagagaaggg tgaattgacc ctgggtggca
31920aaaacaacat agcatctact ctagtgggat aaagtaagat ggtaaggcat ggtgttcagg
31980gtatttctga gtttggtttg attcacaaaa tagattgtga acactgtaat tgcccttaat
32040tttagttaac ctatgtaaat gtaaatctgt gaggtgtcac tacattctgc taaagctttg
32100atgggctcct gccatattct ggtttggctt ttgtattaaa gagccattgt tgttttggtt
32160tcactgtata caggtagact tttgttttaa tgaatagagg tataatctgt tttgaacagg
32220aaaagctgct tttgtattct ggataaagtt catactagtg ggatttcacc tatgaaacta
32280aacaaatctt tgaaaaattt aaaaaccata tgtatttaca cagtgtccat tcagtagaag
32340tcgtttaaat aaaggcttct gccaatatat gaatatttag agctgtattt tattatttta
32400ctttttttga gacagggtct cgctctgtca cctaggctgg agtgcagtgg tgtgaagaca
32460gttcactgca gtctccacct cacaggctca agagatcctc ccacctcagc ttcctgagta
32520gttgggacca caggtgtgcg ccactacacc tggcttgctt gcttgcttat ttattgattt
32580gagatgggag tctcactata ttgcctaggc tggtcttgaa ctcctgggct caatcctcca
32640accttggcct cccaaaatgc tgggtttaca ggcttgaacc actgtacgtg gccttgaatc
32700tgtgttttaa tactatgctt acttggctgt ggtgttgtga aaagatcact gaaaatggag
32760tcagaggcct gatttgagcc agtcgtttgt tgtgggggaa ggaggtcagg ggagctaaca
32820tctaaaggct cactatatgc caggcacaga accaagtgtg tttgcatgta tatttcgttt
32880ttgttgccag actttgaggt aggttttatg gataaggtct ttaaggcaat atcagcttcc
32940ttttaaaaaa gaaattccgg aaactgagtt ttaggctgaa gatctctaac tggtagtagg
33000gacaactgaa ccacagggtc ctaactgacc ctgcgattta tctccttttg cggggggttt
33060cttgataata gggtgcactt tacctcattt tttggctcaa gcatggatag gccacccttc
33120cttttcatac ctatagctaa gctttacaaa tgatatgctg ataagataca agctactcgt
33180tattcatgtg ggttaataga cctgtttgtt tgcttgtttt taagtctata gccgccccac
33240ccccaatcta caatttcacc ttctaaggtt ttagttactc attcaaactg cagtctgaaa
33300atgttacgat attttgagag agagaagact ctagctacgt aacttttgta acaatatatt
33360gttataattg ttcattttac cattagttat tgctgtcagt ctcttactgt gccttattta
33420taaattaaac ttcatgggta tgtacgtata ggaaaaaaca tggtatattt agagtttagt
33480actatctgca gctttaggca tccgctgtgg ggttggcggg gggcggtctt gggagataag
33540tggggactac tgtacaatta tcaggcacac acaggctctg ggattttaca aatgagtaaa
33600agtggttctt gctgttgaag cacttacagt gggaatagag tgaaatacat gaaaatgtga
33660ttttaatatg ttataaatgc tatgatggtg ggagtttgtt ttgtgtaaaa catcctttta
33720attggtactt taaattttaa tattctttca caggtctacc tatttagtct tacactttca
33780aagaactacc tggatgctgt agattttcat gatatacttt attaggtatg ttattaatgg
33840tagaaacagc atggaaagtc ttccagaata ttagacaagg acagttctag tactaaaaca
33900taaaatgcta actaatgtct tcatcaagac ataaaatatg tatcttaaaa aataaattgt
33960aagccaggcg cagtggctca cacctgtaat cccagcactt tgggaggctg aggcgggtgg
34020atcacaaggt caggagattg agaccatcct ggctaacacg gtgaaaccct gtctctacta
34080aaaatacaaa aaattagcct ggcgtggtgg cgggcaccgg tagtcccacc tacttgggag
34140gctgaggcag gagaatggcg tgaacccggg aggcagagct tgcagtgagc ggagattgca
34200ccaccgcact ccagcttggg ggacagagtg agactccatc tcaaaaaaaa agaaattgta
34260ataacaccca cattatacat cagtgaaaac taaacacgtt actaccctag gccttattgc
34320acaggggtgc tacctccaag gagaaatttg tctaggcagc agatggacta gaggtgatta
34380gcctatgagc gaatgaggct acagatcatt cctttttatc tgattccttt tctttctagt
34440tcctaggcct tggaagcact aagtggtctt aagtaatttg catagaatta gttgagttca
34500tctgttaact aactagcaga taggaagaaa actattgtca tgaaattatt taaaaaataa
34560taatgctcca gtttcttctc atctttgatg tcctttggtc ctacctcact gccttcctaa
34620caccattttc tgctttacct caaagctggg gtcatcttga gtttagcctg cttaatccga
34680gtgactgtca gctttattcc actttagcaa ctcgcaggca aggccacact tggaaacttt
34740tcacttggaa tagttctatc ttggtgattt catcagcctt ctttatgtca aatacactca
34800aattcctgcc cattcttatc tcttcgttcc cttcaggtcc ttagtccttt taatttgtga
34860ctttcattct ccaggtccat tcttattaaa tgtctgccag ccagacttta gttgccccct
34920gtccagcttt ctcttgctca gacctaagat ttctttaggt tctttctttg ccttttgaaa
34980tccagctcag cttttaagat tgagttcctt gttacctttc ctgccatcct tctgcagttc
35040ctaatattct tttctttctc ccaaagtgct tttgtataaa cagtcagcct tccatatccg
35100tgagttccaa atccatggat cctgaattca tggatttaac cagctgcaga taaaaaatat
35160tcagaaaaaa aaagatggtt gcatctgtac tgaacatgtc tgtactgttt tgcttgtcat
35220tattttctaa acaatacagt ataacaacta tttacatggc atttacattg tattagggat
35280tataagtaat ctagaggtga tttaaagtat atgggagtct cttatatccc aggaagccag
35340gtaaaaaaaa aaagtatatg ggaggctatg cataggtgat atgcaaatat tacaccactt
35400tatatcacgg acttttgagc atctgtggat tttggtatcc gaggggtgtc ctggaaccag
35460ttccccaggg atactgaagt atgtctgtct atctcatact atatttttcc ctttgtctta
35520ggtagactat cagctccata ggggcaagga tttaataata tttgtatatt cattttattc
35580aagttcgtat acactgcttg ggtcataata tttattacat gcttgagaaa atgaatttct
35640tcgccccttt gttacagctc tgagtaaaca gccatctgcc ttctctgtca tctgttggtg
35700gttgagtatt tctgtagaaa gttacccatt ggcctcagga ctcttactct aaatcttctt
35760cttaggcagt tttctctgtg catgaagttt ttatgtaaac aaatagatga agcctgccct
35820actcatttat ttgctcaagc cagaaagtca ccttcttctt cactttccat atttaaatca
35880tcatttggtg gaattttggc ctaagcaact cttgaattca cgtacttttc cctgtcatcg
35940ccagtgtggt gtagaagcct ctgtcacccc ttgtcgggat gctgtgctgc agcatcatct
36000aacctggttg cagttattct ttcactccct caccgcacac ccttttactt aaaacactaa
36060aagtggcttc tcattgttct taagataaag cacaaattgt tagtgtggcc tgtaaagctt
36120tgcatagcct gacagagaat gtcctgctaa taatttgaag gtacaggatg attttaatac
36180tttaggagaa aatgttctag gaaaagacgc ttgtttagac ttaaggtgag gactctgcag
36240tatgaattag acatctggtg aactataagc tgtccccgca tttaaacata attggttctg
36300agagcctgca actaaagata aggcagaaga atttactttg catttcctgc attcctcttt
36360tcgcttgata gcagaaaccc ctcatgttaa taaaggtggc acaagaggca aaaatacaga
36420ctttatcaca gtgtttaagg agaggtgcat gattaagtgt gtggggagag agtacctttg
36480tacattttat tatatggtga actgtatgtt ttctactttt agtactgttt gtaaatttta
36540cttcttcttg gatttacctt tttcagttat attattccat tatgccttgc tactgtaaca
36600gctaatgatg aaaaacagga tctgtcttta tattttcttc cctccacaaa tgtggatctc
36660atagagttga aaactaggtt gtgatatagt atagtatacc taattcctgt aatgggatca
36720tgttcctata atatggccgc aatttagtgt agaatttttg taaataaaag tgtattttaa
36780gtttaactta aactttcaat gaagtgtttt aaggatttaa ccatgcagca caaatgagca
36840cctttctgta aatgccaaca gtgtaatatg tgtcatttct tcactgattg ttagtttgct
36900gcggattaaa acacaggtga tcatattcag gctggttaga ttagtgattt taatatgaaa
36960ccattgcttt tagaataatc atgggccaga ctgggaagaa atctgagaag ggaccagttt
37020gttggcggaa gcgtgtaaaa tcagagtaca tgcgactgag acagctcaag aggttcagac
37080gagctgatga agtaaaggta taattttatc ttttgtgaaa atgaatatac aattaaggat
37140aggttttttc ccctcctaag ttcaataagt ttttatttaa aataattcta gccaagtttg
37200tatttacaat aagatgagtg aatacttgga agcttaggtt cttgatctgt cttaacatta
37260taccatgcac attaatcagt ctttgtttag tatactttta tttgcatatg cagctgcaga
37320aatgcctccc taaatataaa gggatgcatt tcatgatttt atgtttctaa agtcattgtg
37380attaaaaaaa aaaatacaca cacacacaca cacacacaca cacacacaca cacacacaca
37440gtcaacaaag aaaggatggc aatcgtttcc tgttctctaa ccacttgcaa taaaataaca
37500gatgtggtgt ttttgtatta tttgaatgtg ggaaactata gtgtaaaatc tatatgcacc
37560taagaaaatg ttcttgatat ttttgaggat acactagatt tttaacctgc tttacaggtg
37620ttatacattt tctaacaatg aacaatttct cctttcctct ccttcatttt tttttttaag
37680agtatgttta gttccaatcg tcagaaaatt ttggaaagaa cggaaatctt aaaccaagaa
37740tggaaacagc gaaggataca gcctgtgcac atcctgactt ctgtgagctc attgcgcggg
37800actagggagg ttggttaaca taacatgttg tagtaattat catcatcttt tggtttatgc
37860tattggaaca tttgtttggt tattgggagg aaatcattga cctcagggtg tccatctttt
37920tattgctatt tctttttaat gtgcaactgt taatgactgc tgtagatcac actattagct
37980attcctataa cagagttcta agtgtttgga atatactttg aactaggtag atgcctagat
38040tttataagaa tgttgattta aaaaaaaaag cttttaaatc aaatactctt taatgtcctc
38100atcagatcac tatttagagc aaggttttct gactcactgt tgtaacccca atttgaatta
38160gccatgtggt aagaaatgtt ttaatattca tggacaagaa agctttttat tatatatttt
38220gttcaaaggc taagcctctc tataagaatt tttaaatttc ttgttgagag attggaattt
38280ctttttctat agtactttct gaacgagcta gctcttaatt actccaagag tttcctattt
38340tcaaagaaag gcagtaaatc tatggtagaa tctataatta aatatcccgt taaaacatga
38400ttgcagcaag atgagaagaa aatggcaaaa gtctaaatag cttaggcatt tctgttttta
38460agtgcctgtg ttgtatagaa agacatggca taggatattt aaaggggagt tgaagcaaaa
38520ggggaaagag cgagttggaa ttaaaattgc actatgtagt agattgttta tctgaatgtc
38580taaatatggg aagcacctaa acaatggaat ttgttttaag ataatttttc aacgagtagc
38640catttttaat ataacattat tgtaacaagc aacaatttgc tattgtatga ggccttctgg
38700agattgtgtg acatatgagc ttcaaagact tgtcagtgat atcccagtag caacagacat
38760aatcctaatg cagattttag tgatattctg gtggtcttga tggtgacact tggaatgatt
38820cttagtcatt tatgcgtttt gttaggtgac acctctgtaa agctctgact tataattgta
38880taaatattga ttatacagtg acactttcct cctcatctgg tacaggccag agcctagatg
38940ttagaggtca gtggcatggg ggaaagggat tctttttgat gcccatcaga acgttcttaa
39000agggaataag gatggggctt ttaagtaatt gctttgaaag tttttatttg gtgacctttt
39060agaaatgttg aattgaaaga aaaacctcat tttctctctg gaggaataaa tcttagaaat
39120ttggagaaat taggtagatt cacatggaaa acttattttt gccacccatt atgaatctca
39180gaatgctatc aaaagcctaa cttaggttta taataaaagt caacagcaat aatgaattgt
39240gtcactgtgc taggtacttt gtacacatta cctcttttaa tcttcatgat aaggaaggag
39300tattacactt tttttttttt aatccaggca aggaaactga gccttagaag catttagtca
39360gtttgcctgc tctaatgatc tgatgtgggc ccagaagagc acactttgct cagacacatg
39420aagtattagt gaagtacatt attgacatac aacttgaatt gctcatagta tatttggcat
39480taaatttaag agtattgttt gttcaagtgg atatttacta attgaaattt tcttttaatt
39540ttgtcaaatg gagacaaatc gttgaatata aagataccta atgttcgtga gtttatgtga
39600aaaattggga gaagaaatca gcattttaat aaaacaaaat tgttttctaa agttagtact
39660tccacagtac cacacacaca cgcagattga gaataaacat tttcacagag tatgggggaa
39720aaggaggaaa ataatcccca gccttaggaa tccagttttt gttgcataga actctgacct
39780gattaaggtc agtcattttt tttgttgctg gtgttggtag ctgatcctgc ttcagatgat
39840ccatctatta tttccccttt ccgccttttt aaaccatcac cactgacttt tagaagccag
39900agtttatatc gtttgtgata agcttcttgg tgttatcaca ataaatcgta aagctttagg
39960gctaaaaagg actgtagtgg tctcatggtc caacctcctg acttttcaga tgagaatata
40020tccctgttta ttttttcttt cgtttaagca tttccatcta catattattt cttttatata
40080tttgaaagat tctagtctga agtaggtcag gtagggagga gaaaataaaa gtgattcttg
40140tttggcaaag actttcctag tggtaggctt ggcagaattt cagactgcag tattgattca
40200aacacgtaaa gtctatagca ttcaacattt gaagtgccat tatagcattg ttttaattaa
40260ctgcttgctt ttataagcta attatatgta agtgctggtg tcttcaattt aaatcctctg
40320cagcatgaca aatcaatgac aatttttagt tcttttgtca ggtcttaaac ttatactccc
40380atttggccgg gcgcggtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcggg
40440cggatcacga ggtcaggaga tcgagaccat cctggctaac aaggtgaaac cccgtctcta
40500ctaaaaatac aaaaaattag ccgggcgtgg tagcgggcgc ctgtagtccc agctactggg
40560gaggctgagg caggagaatg gcgtgaacct gggaggcgga gcttgcagtg agccgagatc
40620gcgccactgc actccagcct gggcgacaga gcgagacgct gtctcaaaaa aaaaaaaaaa
40680aaaaaaaaaa aaaaacttat actcccattt gtagttgtag aagtggatat actcagtttg
40740aaaatgactg attttctcca agttattttg gtaaagaatg tcggacaaaa gtttactgaa
40800gtgagtgctt tagatgctga cttcaggtca gggagctctg catttgaacc caaagaccac
40860atctccagta tgtggttttc ttactgtgtg tggttttgtt ttgtttttgt gacagggtct
40920tgctctgttg cctaggctgg agtgcagtgg tacaatcaca gcagccttga cctcccaggc
40980tcaggcgatc ctctcacctc agcctcctga gtagctagga ctacagtcac acgccaccac
41040atcgggctaa tttttttttt tttttttttt gagacggagt ttcgttcttg ttgcccaggc
41100tggagtgcaa tggtgcagtc tcggctcact gcaacctctg cctcccaggt tcaagcgatt
41160atcctgcctc agcctcctga gtagctggga ttacaggcat atgccaccac gcccggctag
41220tttttgtatt tttagtagag atggggtttc atcattttgg tcaggctggt ctcgaactcc
41280tgacctcagg tgatccaccc accttggcct cccaaagtgc tgggattaca agtgtgagcc
41340accgagcaca tcgggctaat ttttttgtat tattttgtag agacagggtc ataccatgtt
41400ttccaggctg gtctcgaact cctgggctca agcaatccat ctgccttggc ctcccaaagt
41460actgggatta caggtgtgag tcaccatacc cgtcccttaa tgtgttttta agatacttta
41520gggcaactct tttttttttg tttttgagat tatagaacct aagcattatt gttcatagaa
41580ttttaataca gaatgtgttt acttttaaaa aacacttctg actttttgaa gacagtgact
41640atatctgttt tacgtttatt tcttttattc ttaagttaat cttttaaaga agcatccagc
41700ttcacactgt cattaatcaa tacatatagg tcaagggatg tacattttat tcccataata
41760tgtcactgtt agtcaagaaa ttgttactag gtgactttca taactttgtc ttgtcaacca
41820gtaataacta tgttctgtag gtcttcatat tggtagttat attcttcatt gtgtctcttt
41880ttccattttt aatgaagaaa ctggtttaag agttactctt gaggttctca ttaatgtatt
41940tctttttcgt acatctgccc atttcttgct gataatcaca agacacttct ccttcactga
42000cttcatatca aaatgttttc tactgtatgt gttatgactg aaagagaagt ttgcttagat
42060agtgcctgtc ttctgggcaa atggtatgat tagtttagta atttaatcca tcttgccaat
42120atacatttct agattcccag gagaatataa tgttcttgta agagttttgt atcttgttta
42180ctaatgaaaa gagagaatat ggtgtatatt cttggggctt cagaatgtct aatagaagca
42240gcatcagaag gggatcacgg tcctcgtatg aagaatttaa aaacttttgg acttttaaat
42300atttacagat ttgctcttca tagtaatatt tgaaatgatt ttaagttcat tgcttagcat
42360ttgatattag cagatttttt tggggggaga agcttctatc aaaataatgt gtaaattatt
42420ttgtatgttg gcagtttgga cttaacattt ttgttgaagg agaagaaaaa tacctgttac
42480atgtaaacac tcgattgcat tttttattga tttagtaatg aagttccttc agttaattgt
42540aaatgaaaat ttagtcactg tttacaaaga aaaaataata tcctagtgta tttcatgtat
42600aatttagtgt actttactca gatacattct ttgagtgtag taacatggtt tctttataca
42660ttgcaggatt ataggcccta taggtttaga ttctcatgaa ccttttgagc aaatatggca
42720gaaagctggt cacttttctc atgtctttaa attaagtgga tggctcttca agtgtctgtc
42780ttactcttag tctgaacata tacactcatt cttattgcct caaggaagtg gtctctgagt
42840tgctttctgt agctccttgc ctcttttaac tattattggt atttacttgg agagttgagt
42900cttgttaggt taactgtcag tcattcccac ctgtataact tgtaaatcca tgcagccttt
42960gctttctttc tggctttatt taggctgaaa tagatgtaac atttcttaaa tgatcatata
43020aggatttttt ttttcttgtg agcagaaact aatataagca ttttatgctt ttccaaaggg
43080ttagcttaaa aaaaaaaggt catttgtgat atttgagttc atatagcatc atatattaaa
43140tacatgtcat ttattatgtt tatattttaa atttgattat atatcttcag tttaaaaggt
43200gaattttaaa aagtcaaatt taggcaacta ataaaactag cagaagttgc ttttcatttg
43260tagtttttct cctagaatat tgtatatata gtttgtgttt tataaattat tgttataaag
43320atcatgtatc ttccccaaat gcaaaaccga gttctgacaa ctatttaaaa ataaaacaac
43380aaatccaaac aaacaaaagt gcttggttaa tctggaatgt tagaaattgt tttattctct
43440gaagaaacaa gaaaattgca ttagaccgag gacttttgcc ataatttagc tttataatag
43500ggattgactt aaatttactc cttaggattc tgtcttacct tctcttagca gattttataa
43560aagaatatca cttgagtaac attttggaaa ggctgggcag atttcataag ctacccaaca
43620aggcagtttt atactagcta atgtgactac ctgttgggct aatgaaacta gtttaaaagt
43680tttatctttt tctctccact gaacagatca ttgtaaaatg attattgtaa aaatttagat
43740aacacagaaa taggtaaaac agaaagcaaa agtccctgta gtccaactgc tctggctttt
43800attctttcag atttcatttt ctatatatac taggaggtta ataatatttt atttttaaaa
43860attattggcc agatatacat cctttccatt ttgggccatc actttacaac ctctgtccaa
43920attttcattc ttttaaaaaa tatgtagtgt ttgacattat ggatatacca taatttattg
43980ccccattctt gatggacatt tagattttta atttttactt ttgcaatcag tgctgtactg
44040aactttatat acatccttgc atcttttgag taattctgta gaagttccta caaatagaat
44100tattagatca agatgatatg catgtttaaa aatttagcag atattaccaa atgcaccctc
44160aaaagtttta cattacaccc ccaccagctg tttatggaat gtctgtttac ctatattctc
44220aacacaatat tatcaatctt aatcttcagt ccaataggta aaacattgtt agaattggtt
44280ataccgtgtc ttaattattc agtgaagtta aatgtcagtt actgtttgtt tatatttgtg
44340aattggctgt tacagtgttg gatcttgtgc aattaggttg ggcttttctt atgattcata
44400aggacttttt gtatattaca aatactagtt ttggctgggt gcagtggctc acgcctgtaa
44460tcccagcact ttgggaggcc aaggtgggca gaccttttga gatcaggaat tctagaccac
44520cctgaccaac atggtgaaag cccatcttta ctaaaaatac aaaaaaatta gctgggcatg
44580gtggtgtgcg cctgtagtcc cagctacttg ggaggctgag gcaggagaat gccttgaacc
44640caggaggcag aggtttcagt gagccgagat cacaagactc aatctcaaaa aaacaaaaaa
44700caaaaaaaaa tagttttttt tgtcatatgt tttgcagatt gccccccccc cattttgatg
44760ttatttctga tatatcttgg ttatacagtt ttttctttta atttttgtct ttcttaaagg
44820ttccaaaagt ctttcttcac ttcaagatta taaattatct acctatcttt cctttagttc
44880tctgttttca tttttatatt ctaatatcat ttaacccatc aggaatttcc tttggtgtaa
44940agaatgggta ggggatttgg tttttaattt tgttcttttt agtttcctgg ttgtttcaac
45000actatttact gagtaattaa tgaatagtga ggggcagttg taaacttgtt tttgaagatc
45060agcagaatca gccttcttgg ttggtggttt cctgggcagt tctaccactc gagcaagacc
45120tgaagtgttt cccttcagaa accacagcct gtgccatctt gctcactcac tttccttcct
45180tccttccttc cttccttcct tccttccttc cttccttcct tccttatttg acagagtttt
45240gctctattac ccatgctgga gtgcagtggc gtcatcttgt ctcacctcaa cctctgcctc
45300ctgggttcaa gctattcttg tgccttggcc tccagagcag ctgggactac aggcatgcac
45360caccacacct ggctaatttt tgtattttag taaagacagg gtttcaccat gttggctagg
45420ctggtcttga actcctgacc tcaagtgatc cgcccacctt ggcctcccaa agtgctggga
45480ttacaggcct gagccactgc gcctggtctt gcccactcac ttgaacctct actactttgt
45540agtattaaac ccagatccac tgatttaagc aaggcttcaa aacaatttta ctgccacagc
45600ctatataaac tatagattta tataatactc tctgttccat tttagttgat ttttccccca
45660atgacagaaa ttgttctttt ttctactcac aggactgtta ttgaattaga aatttgaatt
45720tacatgtggt ggatgaacat cactcttgtt acctgcttca tgtacttttt tgagtgctta
45780ctacctgtga tgattattct gtttctgatc tccagtactt agcaaaactg gagtttttcc
45840gcaaagctgc agatgaggga atgatttacc ttaacagccc ttcaggattt taacctagga
45900ttaagtaggt ttgcatgttt gtgattcctt tcattcaggg cccggcttct gaaggtagga
45960tgcggggaag agctttaagg atctaaattt cctcccagcc tgagcaacat agtgagatcc
46020catctcaata aaaaataaaa aaattagcca gatgtggtga cacgtacttg tagtcccagc
46080tactcgggag gctgaggtga gataatcatt tgagcccagg agtttgaggc tgcagtgagc
46140catgattgca ccactgcact ctaaccttgg caacaagagc tagaccctgt ctcaaaaaaa
46200aaaaaaaaaa aaaaaggagt ctaaacttcc cgatactgta ttccaaatgt cctatgttaa
46260atgctgtgtt atcattcccc gccccttgga atgtagaaac cgttaattac aggataaaag
46320tgaactgaga agcaaatacc cttgtgttgt agggtagagg ttcttcaccc aatgtggaat
46380tggtctgtaa caaatactga acaacacaaa ctgaaataat ttacaatctg atatgaatta
46440ctctttttca tttcttaact ccaacacttg attagttgct ttcattaaat acatctgtgt
46500caatatctta atggggtttt ttcttccgtt tttgtttctg cctctctcct gttggagcga
46560ctcatttctt ttcaagtgtc gtcttcaatc tcccttctcc tattttgcct tctcaacctg
46620attatgaatt cacttccatt attgagcttc tctttacttt atccaaattt gctatttatc
46680tcattgcagt ttttcttcag tacttacttt gcataaaagt agcctgaact taaattatat
46740acacggtcat tttcaccaga agggctagct aatttaaaac ttgggcgtgt tatcttttct
46800ttcctcaagt cctgcagaat atagggtagt ttcagaaatc acccccagct tttctctaga
46860cttggtgaca gctgatgctt tcttctgact cttcctttcc tggagtgccg accttcctgc
46920accttcctcg ctgttgtcac atggaaaggc tacaggatgt tagacaatgt caacagttta
46980ctatgtctct ggcatgaaat aaatggacca accagtatct gagaatattt tttacttggc
47040taattgattg tatgttttcc cctactatat ggaagttgga cttagccttt ctcatgttaa
47100agattattca gaggcaggac ggccatggct gttgtctttg ggatgtccac tgtaaaatgg
47160ggagtcatac ctacctcaca gggtagttgt gaaatttaaa gaagctaact ttggtaaagt
47220ctctagcaca gtgcttggca catagtaggg tgtgttaatt tctttccctt ccctgcaggc
47280cattcacctg ctcttccctc tacgattttc cataacacag tttttacttg gaaccagcct
47340tctgccaaga gtctcagttt ggttgtgtac tcctacaact actatttttg gcttgacttc
47400cctctccagc tcccagtggt ccagccacac agtcgcctat tgtaccagct ggttgatgta
47460agtctatcca tcctcagagg aacctggtta cttaccagta agctgtgttt ctctgaaaat
47520gtagcatcct tggtaatgat tctagtcccc cccatcccct ttttttttaa accattgatg
47580atgaatcatc tctaacttcc ttgtgtgatc ctcaagttgg aactggaatt agagaatcta
47640atttgttgat aaaggtctcc tagtaagttc ctgagtccag gacacatggc tctgaccagg
47700tgaaatgtgg agacccatga ggtaaaaatt cttttcacta ctctgagtga catgagactt
47760aattatgtaa actgtcaagg atgatacatt ttcaaagaaa aataagttgc tggtaagtaa
47820ctgggatttt tgagtaattt ttctgtaagt caataaataa gaatcccacg tttgttttca
47880ccaacaaatg cttttgcatt tgaatatttc ataaatgaaa ggaatatggt tgttagttac
47940ggttaatagt aaagaatggg ataggtttct agatactaga aatacagtga ggtgggggta
48000gaccatcagt tttctaaata ggtgctctct tagcttgaaa cagaaattga agtctccatt
48060agagaaaatc atcaagtgta gtctgttcat tccagaaaca ttttttgagt gcctactgtt
48120tttttgagac actgtgctga gtatcgtttc aagacagagg tgaagccaca cttggctcag
48180ctgcttttgc cctcagagag cttatttctt gtctcttagt gactctcgca tgactcagaa
48240ctgaggcgat gggatactgg ggtatgacag aggtatggga ctggaagtag tacgtagtgc
48300tgcagcctgt gccttaatat tttctgtgct tccataagtt ctttctgtta atgggaaaaa
48360tcagctgact tcattcagaa tttgcagagt atttgctgta tcactagagc aaccatagat
48420gaagcaaagc caatgctcct tctttgtcat agttgaaaac tcattctcta acccttatgt
48480gcgactttgg agttaggtgt taaagcaggt gaataagtca gtcggagagg cagcccactc
48540cccattaagc tttcaaagca cttcttcctt cagaagccac agaattaatt tattcctgcc
48600aaatgttaaa aaaatcggaa tttttttttt ttaagaaatg aaaattgttt tgtactttaa
48660gtcactggat agtatttgat actatcagta tcagtaatta tattcagtat attcggtaat
48720tataagcacc tccaccccca aatttaccca gttaagtaga aagaaggaaa gaagacttgg
48780tagtattaat aagttgttgt tggaggagat gctcctatta cattatgtct ctattttctt
48840tttttttttt tttttgaggc ggggtctccc gtcgtcaccc aggctggagt gcagtggtgc
48900tgatcacaac ttactgcagc ctttgcctcc caggctcaag tgatcctccc acctcagccc
48960ctcaagtagc tgggactaca ggcacgtgct accttgctgg gctaattttt tgtgtgtttt
49020tagtagagac agggtttccc catgttgccc aggctggtct tgaacttctg ggctcaagcg
49080atctgcccgt cttggcctgc caaagtgctg agattatacg cttgagccac tgtgcccagc
49140catgtctctg ttttatatag taaatactgc atggctgtaa ttgttatttt accccatgag
49200cattgcaagg gcaagaacta cagtgcagta attaattaag ctcacgggtg ttgcagtcag
49260actttaaatc caggttttaa tcctggtttt gtaatttgct acctttctga ctagacaaat
49320tgtataactt ctctgaacct cagtgtcctc atttgtgaag ttttgatgct aaaactacac
49380cataaggttg taatgaggaa taattaagat aatatataca agcacttagc acagtgcctg
49440caacatagta cgtgctcaat aaatgttaac tgctgttttt attggattat tggatggatg
49500gatgaaggat tgtatcagag gccaaatagc aggaagggga aagattgtgg gctctggagt
49560gttagtaaac tgttcacacc ttcttgttta ctcgagttaa gagccttatt agtattatta
49620cctttatctt tgcctttttg gaaagcaaat taatagatga atcactgtca cagttcttcc
49680taactactcc atccttaaac ctttacttcc actaaggaag gaattatttt tgtgctgcag
49740tgactgtgat gattgagaga ttatcccact ggcctgatgc aacccaatgc tgagggtcag
49800gtgtggccca tatgccagat ttctactctg aatttcacca caactagttc tgctattttt
49860aagacatttt aaataaaaaa tttaaacatt taatatgtgt gtgtgtgtgt gtgtgtgtgt
49920gtgtgtatat atatatatat aatgattttt cagtttcatt ttactacact tcttttttgc
49980tctattttca ttgattgtgg attatgaatg tatgtctagg atatttttga gaaggctctg
50040gaggacttac acctgggcag tagtactctt taaggaatct cggattcgta gacagggtgg
50100aaagtgctgt ggttatttag gcacagagtt ataccatatt tcagagaatc aaagatgcaa
50160aatttttcac attttaacat tggaaacaac atgcatctta gaatcactgt gataagaatg
50220gattatacct ttgtttagtt ggcagcattt tttcttagtg atacagaaga taatgatgta
50280ccttgaaatc gctgtcatca tagattgtat gaaatatggt gtttcaaggg actatgtgca
50340ctgacacatt ttagcaatat ggtatcatgg caatataagg agcgggaaga gcaggggctc
50400cagagtcagg cttttggagt ttacattcta gcccgagaac catgcgcaac tttgggcaag
50460ctacttatcc tttcttttct atagttttct cacctgtaaa atgggggcta agagtagtac
50520ccatcttaca gtgttgtaat gaggattaaa tagaagacat gtaatgtgtt taaaatagcc
50580tagcacatag aaagtactta gtaatcagct aatattatta attcagagat tacagttttg
50640cagaatagac ttaaatttac tttgttgtga ttgaaacaca aacccattac ccttaatatt
50700tatgtatcat ctgataatat cagcaattga cacttagatt ttaaaaaagg aagataagga
50760agattaactg aacaagtttt cttattcttt ttattttatt ttattttatt tttttttttt
50820ttgagacgga gtttcgctct gtcgcccagg ctggagtgca gtggcgcgat ctcgactcac
50880tgcaagctcc gcctcccggg ttcacgccat tctcctgcct cagcctcccg tgtagctggg
50940actacaggcg cgcgccacca tgcctggcta atttttgtat ttttagtaga gacggggttt
51000caccgtgtta gccaggatgg tctcgatctc ctgacctcgt gatccgcccg tctcggcctc
51060ccaaagtgct gggattacag gcgtgagcca ccgcgcccgg cccaagtttt cttattctta
51120ttaagtaaga tttaagtggc ttatttggta tacatattac tattctgtgt ggttggaatg
51180taagagaaat gaaggatgag ctaggaaata aatgtatagg aaaagcatgg aggagttaat
51240cagatcgctg aatctcatat aagtacagtt tttgattctt actgatattg gtaagtatgg
51300gaagggttgg aggttttgaa aatttggaaa atttgaagca tttttgcacc ctaagtaaaa
51360gaaaagagag aatcctattt ggtttatatg accactttac tgtcctaggt aaggactttt
51420ttttcaaaat taaatatttg ggtaggcagc atctctttac aatatgatgg ctacagctta
51480aggttgtcct tttattctta agagtcaatt ttattttttc tgttttagtg ttcggtgacc
51540agtgacttgg attttccaac acaagtcatc ccattaaaga ctctgaatgc agttgcttca
51600gtacccataa tgtattcttg gtctccccta cagcagaatt ttatggtatg taaataagat
51660atcttctgct tatttgataa taacttattt gaagtaaaaa agcatagata attttattgt
51720caaggtgaat caagacagta taaattctaa aaagctatca aaataacact tgaagtaatt
51780tttaaaaatt gattaaggta gtttttttaa ggcctgtgca gtattactct tttcctatac
51840tctccaaagg aaaagtgtta agcagtaacc atacctagga ttaaaaatat ttaaaagatg
51900ggctgggcat tgtggctcat gcctgtaatc ccagcacttt gggaggctga ggcagatgga
51960ttacttgagt ctgggaattg gagatccacc tgggcaatat ggcaaaacgc tgtgtcctca
52020aaacaaaagt tagctgggtg tggcgcatgt ctgtagtccc aagctactca ggaggctgag
52080gtggaaggat ggcttgaggg aggcggaggt tgtagtgagc tgagattgtg ccattgtact
52140ctagcttggg tgacagccag accctgtctg aaaaaaacaa aaggaatgaa gcttatagtt
52200cttatcctta aaaaagtcag tgtcctgtaa tctaagtctg actttgagtt tttgttaatt
52260gagaacttat tatttaaaac aactttaggt agcattttat tgtgataatg tacattatgg
52320tgtaaaattc atagggcttg tgaaacatga gctgaaacat agttccattg ctaactctga
52380cgcagcagct tttgtaataa aatgctaaag agaaactgaa gcatgtgttc ttgacttgta
52440ttgctaaata aaaaatatat agttgtatta cttaattgat atataaagtg ggaaggctaa
52500taaaatgttg atagaagtcc ttggtgaacc tgctttgggg aagtttttag taacttttat
52560actttgtaca gtagagtctc aacttcagtt actcttctgt agttgtataa atttgagtgt
52620agtttgagaa ttacattgca tgaccttgag ggaagtttca tgttttcaca gactgaaatt
52680ctggaagaat atattattta aatttgtcat taatttatga atcacccatg gattttgctg
52740gtctagcctg ggtgacagag ccagaccctg tctgattttg ctgaccaaag cagattaggc
52800acacaatctt tattgtaact aagatacgtt ttggagagca ggatgatgtg gatatgattg
52860aaaagacaaa atatctaagt gtcacttgat tttggcttag atagaaagaa atcaacccct
52920agtttaaatg agattagtgc aagtgaaatg agatgaaaac aggcctctag tgtgtacata
52980agcttgaatt tgaatatatg aatacattaa aacctgcatt ttaattatat gctcctttta
53040tcccactttt tcttttcctt gtctgtctac ggtacttgtt atctttatga actctccagt
53100tgtcctaaat ttgttaccta gggattattt gagatttttt ccacattccc tggctgctac
53160tagtcctgtg tgtggccttt cccagcgtgt tcttacctgt gggccatgat catagtgctg
53220ggccgagcct acgccatctc accctttaaa gagcttctgt gtcctcccag tcaggcatag
53280ccagtccatt ctgcttatta taattatctt tctaaaattc tgttttcaac caatactctt
53340ttcaaaggcc tcttaagact tagacttgtc ttcacttgga attagtctct ttaaacatgt
53400acttcagaac tgtccagtct ttatctataa ctgctgtcat ttttattctt cattgaaaat
53460gctcttcctc ctatgaatgt caactttctt taccttgtat gcttaactat tctattctgt
53520cttaactttt gtttgattgg ctattcttct ttcttctctg ttgtcttcca aagcttgata
53580aaaactcatc tatcatcttt actagcactg tcaactttga tattcatctc attcatctaa
53640atattgaaat attttatgtt tttgtagaat gttcttattt tacatataag tacatatcct
53700tttggcataa actttaatgg actatcaata ctctgtatcc ctagaatttt attatattgg
53760atgtcttaca tttttttttc attttacctt aaactattac aagttaatgg ctgttttaat
53820aactggatca tcaagtggag tttgggagtc ttagggtagt tttttggtat gggtctttat
53880agttgatctt gatacaccat atttcatcat cctctattaa catctaaagt gcgcgttaaa
53940actgatgatg gctgggcatg gtggctcatg gtgtcagaca cctgttatcc cagcactttg
54000ggagccaagg cgggtggatc acttgagctc aggagttcga gaccagcctg ggcagcatag
54060tgagacactc gtctcaatta aaaaacaaaa acagaaaaac agacgatgtc ttctcataat
54120ctagagcatc tttttctttc ttagaggtat gtacaataat ggtggtaagt tttaatgatt
54180gatgacagac taagtgcatt attttttcta gaattaaatt ttttttctgt caacagtttt
54240ctcagatatg cttattggtg agaggggtct tttatttttt gataaatttt agagtttgct
54300ctctgactag tattttaaat ctggagaact gggtaaagac atgtacacat gaaaaaaagg
54360ttgtatttta gttatttcac atttgatact tagagtaaac ctgcttttta aatatatttt
54420tttcttttag gtggaagatg aaactgtttt acataacatt ccttatatgg gagatgaagt
54480tttagatcag gatggtactt tcattgaaga actaataaaa aattatgatg ggaaagtaca
54540cggggataga ggtgagccat atgcttcttc tcttggaaaa aggggctaaa gaattgagag
54600acacttttgt ttatgaagca tatagggcat gagaaaaatt ttaatattaa aattaagttt
54660tgcactgaac tataagggac tgaacctggg cccaggccta agattttcag tattttccct
54720aactattttt gggaaaatta gttaggagga tcatgtttgc cacctgataa ttatgcatag
54780ttggttataa cataatggca ataacatgta aattaaatag aacttgagtg tatgtagatt
54840ttaagattct ttagtagtaa aattaattag gattggggct ctgcttctgt ggcatatagg
54900ggctccaaca gcccctacta ctaaaaaata ccgctcctct agggactaca gtacctgaaa
54960ttcaatcctt agagtcatgg tttcagtttt ttgtgtccag gaggccctgt taaagtgtct
55020gaaaggataa tatttgtaat atcatcatcc attgtcatta tcagcagaaa gcagggtctg
55080aaatgatcag ttaaaggaca gatccattgt ttgggaggag gccaaagcca caatcagttc
55140ctagaagatt cagttttcta ctagaaagtt ttggggaggg gccattctac agaaagtagc
55200aggtattaaa gataagtttg cttcctttgc ctaacaccag tcctgaaaat gatcttatct
55260tttcctcccc tcatttcaat aataatgttt tagtgccagt tactaggcta tgcctgtttt
55320gtccaagtag aaaaaggata cataaacttt tgacattatt gcttctcctg tgtgtttctg
55380acatttgatg cgtttcagaa tgtgggttta taaatgatga aatttttgtg gagttggtga
55440atgcccttgg tcaatataat gatgatgacg atgatgatga tggagacgat cctgaagaaa
55500gagaagaaaa gcagaaagat ctggaggatc accgagatgg tatgcctgat tattaggatt
55560ctgtgtagcc attacagctt tctttcaaaa acagtagaaa gagtagaaat agggcttagt
55620ttcttctttc tctttttctt tctttgttaa atatcacatt gatagcagta taatcaaaat
55680taacatatta tggccaggta gggtggctaa ctctgtaatc ctagcacttg ggaggctaag
55740gtgggcagat tgcttgagcc caggagttca agaccaacct gggcaacata gtgagacccc
55800atctctacta aaaagtaaaa aaatgagaca gggtgattgc ttgagcccag gaggtgtagg
55860ctgcattgag ctgtgattgt gccactgcac agtctggctg ggtgacagag tgagaccttg
55920ccttaaaaaa gaaaaaaaaa agcataatac ttgcaacatt atcttcactt gagtatcttt
55980gtttcctttg gctagcaaag aacgtaattt tttgtgtgct tcactgggca tcattataat
56040atataacatt gatattcacc gtgtacaagt tgtgtactaa tcacttctta tgcaccagct
56100cacttaatcc tcataatggc ttcatgagat ggatgttatt atcagatcca ttttcttttt
56160cgagacggag tctcgctctg tcgcccaggc tagagtacag tggccccatc tcagcttact
56220gcaagcttcg cctcctgggt tcacgccatt ctcctgcctc agcctcccga gtagctggga
56280ctataggcac ctgccaccac acccagctaa ttttttgtat tttttagtag agacggggtt
56340tcaccgtgtt agccaggatg gtctctatct cctgacctcg tgatccacct gcctcggcct
56400cccaaagtgc taggattaca ggcgtgagcc actgcgcccc acctgtcaga tccattttct
56460atttgagggg atagatttag agaggttaag taacttataa gattacacta ttgggaagaa
56520acagagtcaa tagttggtgt tctctacttg gcaaagctca tgctaaggca gcatagaata
56580gaataatttg gcgggtgaaa tagcaatttc taagaagcgt atttcaaaaa agagaaaata
56640acaaaaaggt accttattga ccttattgat catctagttc agctccttca ttttacagat
56700gagtaaacag acccaagagg taaagtgatc actctaagtc acaaaatcag ttagtagcag
56760agctgggagt agaacctagg ttttctgctt cccagtgctc ttaaagcttt tcatatttga
56820atttgaattt tgtttttgac tgactggcat tccacagaca tgtaaagtat gtgagaagta
56880agtaaaacac aaaatagaga tgatttctta gaaaatcagc tttgttatag agacataatt
56940gggtagagaa aatgaaagat caaaaacttg tttacttcca ttcttttttt cctttcatat
57000tctcctgttt agataaagaa agccgcccac ctcggaaatt tccttctgat aaaatttttg
57060aagccatttc ctcaatgttt ccagataagg gcacagcaga agaactaaag gaaaagtaag
57120aatttgttcc tttgaggcaa tcttgccctg tatggtatgt aactcaccat tttggtttat
57180tacaaatgga atcaatgtag cggatgagcc actacacttt gtttacagtg tttgcaagat
57240acttgaagca acatgtgtac ttgtggtact ctgcattaca aaatatttcc tgtagataga
57300ataaatacat atgtataatt tatatataca cataaacaca cacatataca taaaatttac
57360agtagtacat ttacaggaaa attatctgga tactggtaga aatttgatgt ttagttaaaa
57420ctaatataat atccttttcc atgatatatt tgaatcatat cgatgaattt gattcttgat
57480aacaccatgc acaatattta gttggctctt tatctaaata gagccattcc tttatgtttt
57540aggcaagata aacatcaaaa gtaacacatg gaaacctttt agaaactgtt ttcaaaaaag
57600tgatttttgt ttcatgttta cttaaatttt tcttggttaa tgtcagatat aaagaactca
57660ccgaacagca gctcccaggc gcacttcctc ctgaatgtac ccccaacata gatggaccaa
57720atgctaaatc tgttcagaga gagcaaagct tacactcctt tcatacgctt ttctgtaggc
57780gatgttttaa atatgactgc ttcctacatc gtaagtgcaa ttattgtacg ttttcatttt
57840ctatctttgt tgtggaatta tgttttaaag cagcttggag agtgctatca tttattacaa
57900ctagaattta tcatttaatc ttgtagttac tttgacaaat atctttagat ctcagtatta
57960ttatttttac tttgttgctt gaggattgct ctgaaatctt ttgcatgtat ttcatttgga
58020ctactatttt ccactaacat ggaattcagg tcagtgattt tttttttttt cccccgtaag
58080tgctaactaa gcagttgttt tacaataaaa ctattattat gaactggtag cccagagcaa
58140cattgctgat attgatgaat aaattgtgtt aaataagaaa ttggccaaaa aaatgttcag
58200gtaagtgctt gtcgatttaa tgtaatttta ttttatttta ttttattttt ttgccctctg
58260ggtaagttgt tttttaaaaa tacctgcatt tgaatacaag taaaacgtaa aatgttctta
58320gtgaaaatgt aagtatggta tatacaaaaa tacttttttc ctctggcatt tctagggaat
58380gtggtttctt agtaaatttt cctggtaatt gaaacttcta agcacagttt aaaagcgtca
58440actacttttg aggcacatat tttgaaaatg tatttaatac ttcctaattt tcctagagta
58500gtttgcttat tatagtttgg tttttcctat attgtatttt agtacgtctg tctatggcat
58560ggtaatttct ttaggggctt tgacccattg taaaatcgtt ttcccctgta ctcaacggcc
58620ccacattgct ttgttgtttt gagttcctgt gcctaccatt gacagattta ttcctcctcg
58680ttcaccaatg ataacgtctt tttaagcttg cccaagcagc tgtacctcac ctcctcctaa
58740gtgtttgctc tacttgtttt tgctgcagct aataatgtgt tgagtgatgt aatacattgg
58800tctggaaatg ttaagttttg tttttgtgtg tgacatatta gtggtttagt tatcttaaaa
58860tagaaaaact tgaagtagat ttttagaatt atcattatat tgttacctcc ttgctcttgt
58920tctaactcct catctagttt aaattgattt ggtagtttta aaaattcgta gtaagtcatc
58980catttgttgc ttcagccatt ggacagttaa gcccttgaaa tagttgtctt gaatttcatt
59040ttaatttccc tttacacacc atgaatttat gaattacatc gagtttttat taagactatt
59100ggacattgta tgtagatatc actatagcaa aagaattgag tggaagcact attttggagt
59160cgctgaaagg tccttccaat ttgttgttta tagatgtagc atttaataaa gtttttttgc
59220tgtaaaaatg aaccatagaa gtaggacact acttttaaac attacaagtt ttttattgtg
59280ccattcagag atgagtaatt tttttttttg ttaacttgaa tcttgaacct gttacttacc
59340tcattctagc tggggagaac agtggaatat tttactttaa taaagttggc tttcatgggg
59400ctaattggct gcctccttgt agcatttggt ggccatgggt ccaactgtgc taggcccact
59460tttacttctt tttacagtag agccagtgtc ttcatcattc agtcctattg agttctgtag
59520gaacttcatt gttttacgtt aacttcgaca aaataccaca catggtatat ttttcttagg
59580taaaataagt tactaaataa atcattaaat atatataatc atgcattact tatggacgga
59640gatgcattct gagaaatgtg ttgttaggtg attttggcat tatgtaaaca cagagtgtac
59700ttacacaaac ctagatggta cagcgcatga cacacctagg ccacatatcc ctgcagcatg
59760ccactgtact ggatactgga ggcagttgtg acacattggc aagtatttgt atgtttaaat
59820cataataaac atagaaaata tacagtaaaa atacaatatt atcttatggt accactgttg
59880tatatgcggt ccatcattga ctcagatggt atgcagcaca tgactgtttc ttttttgttg
59940ttgttgttgt tttttttttt ttttgagacg aagtctcgtt ctgttgctca gtctgaagtg
60000cagtggtgtg atttcagctc gctgcaacct ccgcctgctg gattcaaagg attctcctgt
60060ctcagcctcc tgagtagctg ggattacagg cgcccgccac cacgtccagc taatttttgt
60120atttttagta gagatggggt ttcaccatgt tggccaggct ggtcttgaac tcctgacctc
60180aagtgatcca cctgccctgg cctcccaaag tgttgggact acaggtgtga gctaccacgc
60240ctggtcgatt ttatgttgaa tatagcattt tgtgctttag ttttctggtc tcttatcttg
60300gggatacggt agtacttcct ttacagagct gttgtgagga ttagatgaat taatgtgggg
60360aagatactta aaatggtacc tggctcttgt tagctattgt tgtttttaaa ataggtcatc
60420attcacatgg tttacgtttc caaaaagtat taatatgaag atgtgctggg cgcggtggct
60480catcctttta atgccagtgc tttgggaggc agaggtggga ggactgcttg agcccaaaag
60540tttgaggctg cagtgagcta tgatcatgcc actgtactcc agctgggtga cagagtgaga
60600ccccatctct taaaaaaaaa aaaaaagtat gaaaatgtgt acaataaagt ctcccaatga
60660ctttctgttc cccatccttc gaaattttac ctcactcttc cacttttatt agtagttaac
60720cacttttatt ggttctcgta ttttttttac agtttctttg acaagtataa agataccctt
60780ttttctgacc gtcttattta catggtggca tagcattcag gcttttccct ttttttggaa
60840taaggatagg atttaatatt gtagctatta gctttatctg tatagctgca tagcctgtgc
60900tgtaggaggt tccagaactt actggactgg tctctaatgg tgaccatttg gattattttg
60960agccttatgc tgtaacgatg ccacagcaaa tatctgtacc catttcatgc aagtttaagt
61020ttacctgata aactctattt aggtattgcc aaatgacctg ccatatgggg atgcagcact
61080ttaaagccct accagcaaag tcagagagcc ctgcccatag aaggtgttac caaactaatt
61140tttaaaattg attttataag tgaaaaatgg cttttagcat tatttttaaa ttcttgtttt
61200tctttgtttt ttaatctctg cttcccacag gtgataagca ttgttttaat atctggattt
61260aattcctttg aatgagggta ggatcttcct atatgttgaa gagtgaacta tttttattct
61320ttgttttttt gattttgtga gacgggtctc gctctgtcgc ccaggctgga gtgcagtggt
61380gcagtcttgg ctcacggcga cctctgcctc ctggattcaa gtgattctcc tgcctcagcc
61440ttctgagtag ctgggattac aggcgcgcac cacctcacct ggctcatatt tttattttta
61500gtagaaacag ggtttcacca tgttggccag gctggtctca aactcctgac cttaggtaat
61560ccacccacct cagcctctca cagtgctagg attactggtg tgagccactg cgcctggcct
61620atttttattc ttggtctcat agatcttttt gatgtcttag gagcttttta tataatcagg
61680aaattaggtt ttttgaaata tgagttgcaa tttttttcaa gtttatttgg taaaagtccc
61740ataagcaaag tttaaacttt tttttttttt tgagacagtc ttgctctgtc gctcaggctg
61800gagtgcaatg gtgtgatctt ggctcattgc agcctttgcc tcctgggttc aagggattct
61860tgtgcctcag cctctggagt agctgggact acaggcatgt gctaccacat ccagctaatt
61920tttctatttt tagtagagat gtggttttgc catgttggcc aggccggtct caaactcctg
61980acctcaagtg atctgcccgc ctcagcctct gaaagtgctg agattacagg tgtgagccac
62040tgcacctggt cagtttaaac attttttaaa aagtagttga atttatcagt tagctttccc
62100attccaagat tataaagcgt ttctcacttt ttctagtatg ttttaggctt catttttaaa
62160aacataaatc tttgatccat ttggaattta atatgatgtg gattataaat ctgatcctcc
62220tcctcacttc caaagttgcc tagttgtttc atttactgaa aagttcatct ttcactacct
62280tgagatattt ccttcattgc ctgttgccat atgtatttgg gtttctcaac attgtgttcc
62340tttagtctat tcatgaggcg gtattcagag atctcctggc aattcttgtt tttctatata
62400aatttattta tttagagaga gagatatata tacatacaca catacataca tacacagggt
62460cttgctctgt cacccaggcc agagtggtgc agtggcacaa tcatggctca ctgcaacctt
62520gacttcctga gctcaagctc ttctcctatc tcagcttcct gcgtagctgg gactacaagc
62580atgcaccacc attgctggtt agttttcttt ttcttttttt gagatagggt ctcactatgt
62640tgcccaggct ggtcttaaac tcctggcctc aagtgatgct cctactttgg gctcccaaag
62700tgctggaatt acaggcgtga gccactgcac ccagcctata tacatttcaa aatctgtttg
62760tctagttctt tttaaaaaaa attagtggta tgtttattgg aatcccatta aatttataaa
62820ttacctaatt tctttttaaa atataagggt taagtctaac taaccatacc atcacctctc
62880tttttgtgtc ctttaattat ctcccaagtt ttctttatgt gactcttgta cattttttgt
62940tgagtatttc taggtattaa acttgctgct gctgttgggc tttttccaca ttttgtcttc
63000tgttttgtac cctgctacct tactgcattg tcttcatgtt ttatcagttt ctcagtacat
63060tcttaggagt tttccagctg tgtaattata ctgtctgtag ttattaatgg ttttaccttc
63120tatccagtct ttataactga agcttctttc tcttttctac ctactttatt tatttatttt
63180ttggttgggc gggggagggg agtggggagg ctttctgata aaaaccagaa agcctgctag
63240acaaattcta aaagagctgt aactgtcttt tctacctact ttagcttgta gtttcagtac
63300agtttaaaaa ttagtagtgc tggtagatag agataaatgt tctgtctctt ctggatgagt
63360tttagaaaat tattctttac atccaggttt tgagatttat ttgtatgaag tttatgtgtt
63420ctctaatgtt cgttttattt ttgttaatat tcttgttctc tatatatttc attgtcactt
63480ttttgttaag aagtggtttt tgtattttaa attatgtatt tttttcttca gagaaccagc
63540tacaatgtta gtttaactca taaacagaaa aacagttgta ttagggttcc ttaacaaacg
63600taatccagca ccagattagt attggtgtta ggctgtctgg agcctaattg ctcacacgct
63660tccaacagaa tctgagcctt gaatttttct tctttaaaaa cacaactttg tccttttttt
63720tttttttcct tccttttctc agtctttaaa tatggctttt tacaaatatt taaaagatga
63780tttgttttgt ggaaatgtca cttgtttttc tccaaattaa ttttcatctt gtataattct
63840gaatagtcca tttccagcat ttcccttttg tatatgagga agtaagtttt tgcaagaaat
63900tctgtgaagt tagcactgct gtcaatgttc acactctttt catgtagcag tgtacccgca
63960tttgaatctt tctgttacat tattttggaa ttttaggttt caaacagtgt atctttctaa
64020aatccgtttt tttgacattg taattttctg tggcaagaca ctataagctc tcaccaggtt
64080cttggattgg gtatgattca caggaattga atgttagtaa tctggggctg tcctctttat
64140cattaaaaat gagtttttac aactggtgac aagctgattg ctgacctttc tttagaaatc
64200aagaaattgt atgtcagaat taaaaatagg aaatctgatt taattgtaga gggtctatca
64260actgcttaga cagagatagt aagattcaat ttaagtaaat gtttataacc atagttatgc
64320gcatcagttt tacttgcaag gagaaaaatg agaaatcacg actcattcca gaatttactg
64380tttttccttc ctgcttaatg gttggaggag gaggaatgga gaatacgttg tgatcattca
64440gtaagagcct gaaggaaagt tgtatgaagt aacgtaaacc acatattagc aagattataa
64500tccattaatt gacttttcca gtggaactgg aagagtgaaa aagtaagtat tttatagtta
64560tattagattc tttgtttcat ttattttgca gcttttcatg caacacccaa cacttataag
64620cggaagaaca cagaaacagc tctagacaac aaaccttgtg gaccacagtg ttaccagcat
64680ttggtaagac ttagtgccta attattgcag agggtacttg agaggacttt gcactttggt
64740ggaggtgatc aagtcagcgt taatgttgtc tgcacccatg ctgttatggg ccatatgata
64800gacagagctt tctcacccat gctgtttctt ccatagctca tgtactgcac attttagtcc
64860ttcattaatg tggtattatt ctttttaaaa tctgtgttat ctcttcagca acatttcaag
64920gtctttagga tcaaggactt ttatgccttc cacaaagtct atgagagttg caaggcacag
64980atagtccgct tagaaagcag gcatgcagta atcatacgca gtagatccca agcccctctc
65040atagccatat ccctctactt gagttttaga tgcactgtca tttcagctat gtgataggtt
65100ccacagattt ttttttttta aatgatggag aacaggtaag gggttaggaa aatatgaggt
65160agaaaagttg tttttacggg tactctctta tttttaccat ttcccctctt tgaaccaagc
65220cactcctacc taggaactaa atgggtatat attgcctgtt ggattttgga cagaagattc
65280attgaatggc acctgcagaa ggtatcctat ttttaagcaa tttggttttt gtagaatgaa
65340gtataaaact gttggctgct gtcaaacttc tcccttctat ttccactaaa aaaatggaat
65400tcttgagcac ttgttttata atattcttta caaggcagaa ttttgtttgg ctcatctaaa
65460atgtttctgt ggtctctata aaccatgctc ttaccattgt tttatacttt gagactggat
65520tattgtactt cataatgcaa gatgtaaccc tcacagtctt attcctgaag ttcctttcat
65580gtcttcctgt ggctgtgtat ccttcacagg aaaaaaaaaa atgttggatg ttttaatagt
65640aagacaggaa gtgacaaagt caagcatgtt tgtgttttgt gttcttgtat agttgaaata
65700ttaacacgaa gaggtatgca ttatcttaaa ctctgcatag gtagtctgac tccgtgcaca
65760ttaggtatat gattcttttg taaagattca cttttaaata gactgtatgt ccatagagat
65820aattaccttt attacatgaa gtatatttca tactttatct tcttatattt taacttaatt
65880ataactagct aatatatttt acaaattcac aatatagaac tgtcttgcct gatttttgta
65940ccattctagg aatatataga acccatattt ctctttctga aattttcaga ctatcaaaag
66000catatcaaaa caagtatatt agacatgcaa atgattattt gtgataaatg gataatgtga
66060tacatttttt gactaacctg gcttatatag tatttttttt tctcttccat caaaatgagt
66120tttagaactt tgccctgatg ttgacatttt tcatttcgta ggagggagca aaggagtttg
66180ctgctgctct caccgctgag cggataaaga ccccaccaaa acgtccagga ggccgcagaa
66240gaggacggct tcccaataac agtagcaggc ccagcacccc caccattaat gtgctggaat
66300caaaggatac agacagtgat agggaagcag ggactgaaac ggggggagag aacaatgata
66360aagaagaaga agagaagaaa gatgaaactt cgagctcctc tggtaagaca cgtctaataa
66420ctgggtttta ctgttctgtg aaagttcgtg ttgtgaggat taaggatgta taatgcattg
66480aataattttc ttagttggtt agtttcagta taaagaccag agttatctca agaatgtgta
66540gctgtgttgt ttctgtttcc tgcctgcacc cgtaccctag cttgtggtgt ttgccctgct
66600tggttgtttg aaagctgatg atgcacttta ttctcattct ttgtgccatt ttcttttttc
66660gatctttctc aggtagggaa taatgaaatt tggatcattt ggtttaatat tcttgacgtt
66720ctgtgagtag ttttgttgga aaatgtgaac tacgatgggt tagtgttttg ccgattggat
66780ttgagttgtc ctcatctttt cgcttttttc ttaagcacac cctgaattgt acttcttaat
66840attatttcca atcatttctt gaccagtgct tacatttggt tttgtagaag caaattctcg
66900gtgtcaaaca ccaataaaga tgaagccaaa tattgaacct cctgagaatg tggagtggag
66960tggtgctgaa gcctcaatgt ttagagtcct cattggcact tactatgaca atttctgtgc
67020cattgctagg ttaattggga ccaaaacatg tagacaggta agatatccga taaaaatgtt
67080gttaaaagag cttcaaacat agagataaaa ctgtactcgt tgtccaaaca aagaaaattc
67140ttggttatta ctaagctcct attcatctcc taaaaataat ttttttttct tcccaagagg
67200gaattgaatg aaaattattc tccaggtatg ttacagaatt tccccaatgt agacttttaa
67260ggttagatag cagtagcttt taaaagctag taagaattga aatttagcat cacagttctt
67320gaccagaata taattacagc tacccctaat gtgagggtag ggacagcgat gtgtgttata
67380tccccagcat ctagcagtgt cacagaagag acaaagacat ttttctggta tgcatgagta
67440taagaatggt ttgcctaaat aagactgtcc tcatggctct gtgactgtgc ctcttgtcag
67500gtgtatgagt ttagagtcaa agaatctagc atcatagctc cagctcccgc tgaggatgtg
67560gatactcctc caaggaaaaa gaagaggaaa caccggtgag tctgtcatga agctccttag
67620agaagtcaac atagatagac actgcaggca aggcccttcc taagggctgt tgttggtttc
67680tacttagtct atttttaaaa aaccttaaac tgccatcaaa aacagaacta tggaatctta
67740tttccactgg gaattgctag tatttttcta taagaataca gcagccttca gtatatttgg
67800tatgttaaga gtcataaaaa ttacggttac cagactgcat ttgggttaag aaaaacatat
67860ttagtagctt ttgcagtaaa ggttacgtaa acaattactt taacatcatg aaatgttctg
67920tgtttctgat gtgagctctg ggccagtttt tagaagtatc ttttattcca ggagcttgaa
67980tttctaagtt gtgtggcatt gcattccgat actcctaatg ggtaccctac tttaagcttg
68040tgtgaatgtt attttcacct tagcgaatgt tttcaggctg atttgatttg taaatgtaga
68100accagaaaaa ttgatgagtg gactatctgc tctaatctcc ccatacctct acctcacatt
68160tttaaaaatg agaaacctaa ttgggtaggt aagggtgcag ttagattatg cttcttaaat
68220tgtgtacagg ctcatgttac attttcttac tttaacaaaa ataagtgtag ggccaaccca
68280atttagaatt tttttaaagt caagttttta tttttatttt ttaggcttta ggagatgctt
68340ctgaaatttt ggttgaatta tttctgacca cgtagttcac ttgcttggtt tatgatgcct
68400gaaataagag gaagtgatca gtgtcatcca catcagaata aatcaacagg cagacacacc
68460tgctgctttg tgcagcattg ggagctcagg agttctgacc aggagtcatg gatgaacaca
68520ggaaatgacg tcttgccaca cctggggcag cctgagccat caagctgttt gagttgcttc
68580aaactgatgg caaatataaa ctgggcaggg catgactctt ggctttaacg cattcctgta
68640ttcatggcac agatagatcc agttaagcag ctctctgttg gatttgtagc ttcccgcaga
68700aatttggttt aattttcttt gtgtttttgc aggttgtggg ctgcacactg cagaaagata
68760cagctgaaaa agggttagca tctttccatt cctctcatta ttagcttaac aatatctgct
68820ttgttttcat ttgttttaga atagtaactg gattagagct tgggttattc taatataatt
68880gccttctgta tgttaaacca atttgaatgg aggacgtcta ctgatgaatc cccagtcaat
68940tctcttctgt aaagtggagg ctgactggaa ggtgtgagtc cgagtcagtt gaaggagaag
69000tgctttggga tgggactgag atgtagccgt gctttagatg gaactcataa gcacttgggg
69060gtgggagagt attttttgcc atcgttgtgg aaaccggaat atgtgtaatg ttatgcattc
69120agtaaaggca ggccagctac actccacagg tagtagggaa gaatgtactc gtgttaattg
69180tgtatgatcg tttccatctc cctggattca ttggcctgca tgatgttatc tttactcaga
69240cggctcctct aaccatgttt acaactatca accctgtgat catccacggc agccttgtga
69300cagttcgtgc ccttgtgtga tagcacaaaa tttttgtgaa aagttttgtc aatgtagttc
69360agagtgtaag tatttgttgc tttgatgcaa ttgcatgaga actaaatagg tctttggtta
69420gcaatttaaa aaatcaaaaa taagaacatg ggagcactcc cttgtttact tgacgaaact
69480catcaatttg acaagtattt attgagcccc atacctggcc ctgtgccagt ggccagtcag
69540tcgcctgggt gttgtgtgtc tgtgtgtgtg aggcaggcaa agttgtatta aaggaacctg
69600aattttattt ttttcttctt tgatcattta aattaagttg tattaaagtt ggcacagatt
69660gtaagaggaa tctagaagga gctacccaaa taatttttgg gcaccagaaa tcgtcagagt
69720taggagggtt ttagtcttca gattaaagga atgtagcata aacatagtag atttttataa
69780ttgtttaatg agactgcaca tgaagcttgg gtattaaggg agtgtttaga actaggggct
69840attggaatgg tcaaggacca tggatattgt tccatccaga ccctttattc acaccgactt
69900taaatatata cactatttaa caaatgaaaa atggaaaaac aactcagtgg tggtcttttt
69960cagtgcaaac agctataact tcgctgttaa tacttccatt tccttgtcta tatagtaggg
70020taataaggtg gttgtgaggg ttgagagtca gtgagatgcc cagtacagcc cttgccacgt
70080atctttctgc aagtttttgc atacggtgat gagtgaagaa cctccaaacc tctctctgaa
70140ggtcaaaacc gctttccggg atgccgctgc aaagcacagt gcaacaccaa gcagtgcccg
70200tgctacctgg ctgtccgaga gtgtgaccct gacctctgtc ttacttgtgg agccgctgac
70260cattgggaca gtaaaaatgt gtcctgcaag aactgcagta ttcagcgggg ctccaaaaag
70320gtgagcaaca agtcacttct ggaagattgt ttgtagttag ctatttagtg atgcaaatgt
70380caggattgcc ttagatgatt tagctggggc aaaaagtaaa agtgatcctt gaaaggtgca
70440actgatgaga aagtgttcat aattttctct gggtaatgca cccttgggca gtctcttcag
70500ttttatatag agcaccatac tctgatagta ggagaaacca gcaaattctg agaagtagcc
70560attcatggta tcagatttag gaataagagg tattttttct acctgtttaa tagattattt
70620gaatttgtct tttagttaat agtttatcta gtatccttaa tgcaaataaa tggtgatttc
70680tatcaaaata tagactcatt ctcatcaaag agtatttata gattccttgc tatgtagagt
70740aaaagatgaa atttcccatg gcaggttttt atagacttac ttcctgtttg tttaataacc
70800ttgaaaaaaa cccagctagg aactatatat ttttagtctg gggaattgta tgtaggtgag
70860ttaactctat cagccaggaa gtaatgattg agcaaaagac acttcagcag catgtatttg
70920ggaaatttcg tatctttttt ttttttttag ggcagatgat aagttctttc ttcagtcagt
70980tctttttata ataatagctg acatttatta agcatgtaaa aataggcact gttgtgagtg
71040ctttagtgga tttgttcatt gattctccta accctgtgag tgaggagtaa gtgttaaccc
71100ccattttacg ggtaaggaaa cccaaagtca caagacttgt aaaggagcag gagatcaaat
71160cctccaggct cccattaacc tgctcttatg ctctgtgtgt gtgtgtgtgt gtgtgtgtgt
71220gtgtgtatgt ggggtgtaga gtagacatat ctttgttgtt ggaccattta tttataattg
71280agaacacact tcttaccagc aagtcccctt ctaccagaaa ttctgctcca ggcaaaacat
71340tgaagttctc ttggttttgt ttgtgtcttt gaaccaaagt ctgtgtttat ggcagagagt
71400tgtgcagggt ggtgggcttt ttgtttttag ctttgacttt tttcttttct gttagacatt
71460tagatgattt tactctaggc agttatatgt ccatttaggt cattggatca cagtgactct
71520ggttccgttt ccgatggcat acctgctcag acctaaaaat ctcaatttcc cccccaaaca
71580acttaccatt gtactccttc ctcactttgt tcagaaagtg ggcaattcta ttcatactga
71640catgtcctct ttgtaagaca ttttttaact cttaaaaatg ttaaactatg tagatacctt
71700ttaccagttg ggtttcattt gcatagcagt atttagctaa tttagtttct gatcagaagg
71760ctatttggga agttcacatg acaggtgagt ggtaagatgg tccagaatag gaatagatag
71820gaagcctttg taaaggtcac aagaaaattt tggatgaaag cataatactg agccgtgatg
71880aaaaattggc atatgttggg gaacacatcc ctaaatacat aatttatagc aatgatcatc
71940ttggcatttc tgctgaaaat agactactgg actgacaaga tcatgataac acctcccggt
72000agtttcttgt gttatcctga ggaggtgggg tggaagaaca aatccaaagc caagctgcta
72060tgggcttcag agggaaccaa cgccagtgaa gaatcagggg gtgtcctggg gctgaaaatg
72120gaataactat taatagaatc acttggggaa agtagaggga aaggtatgga gaggaagagt
72180gatttggtgg tgtccttata ttaaattcag gttgaaagtg aattactcga ggaaatcaag
72240ggctgaagat acagggaagc caaaagtgca gcaggcctag agcaccttgc tgaacgatgg
72300tcattgcaga ggaccaacac caccaaaagg ttttctgtaa gacagagatt cttatctgct
72360gtataaggaa aacataatgt tcatagccat tctcagcagc tttcacgttg actgaagctg
72420tgtgcccaat tactgcctta gaacaaacag gtctgaggat ttacagtgat agcttttgtt
72480ttcattctgt agtctacttt gtccccagtc cattttcacc ctcctttttt gatgatgtga
72540ttgtgtttta ttctctagca tctattgctg gcaccatctg acgtggcagg ctgggggatt
72600tttatcaaag atcctgtgca gaaaaatgaa ttcatctcag aatactgtgg agaggtaagg
72660cactgataac ctgtattcag gtggcattgt atatactaac tttactttat tttagattga
72720ttttattagg taagtctgtg ggtttgattg gaaatgaatt gccataaact gccttttcag
72780cctggacttc tgcatgtttg tggatttgca tgcttagtaa ctggattgtg ctgggcgcgg
72840tggccgactc ctgcaatccc agcactttgg gaggccgagg caggtggatt gcttgagctc
72900aggagttgga gaccagcatg ggcaacatgg caagacccca ttgctacaaa aaatgcaaaa
72960attagccggg cgtggtggtg catacttgta gtcccagcta cttgggagct gaggcaggaa
73020gatcgcttga gcctggaaga gcctgggagg ttgaggctgc agtgagccat gtttgtgcca
73080ctgcactccg gcctgggcga caaagtgaga ccctgtctca gaggggaaaa aaagcaaaac
73140aaaacaggat tgcttggttc tagccacatt tagtttttct cgtctaggga caacagggag
73200aacaagagct ttaccataga gtggcctgct taatccacaa cctagttgat aaggacctag
73260aaacaacaac gtcattagtt attcaccttt taaattgtcg acagtgttac cgaaaaatca
73320taggcctagc ttcagtttgg aaccagctca cccaaatttt tttttttttt tttttttttt
73380ttgagacaga gtttcgctct tgttgcccag gccggagtgc aatggcgtga ttttggctca
73440ccgcaacctc agcctcccgg gttcaagcga ttctcctgcc tcagtgtccc gagtagctgg
73500gattacaggc atgcgccacc gcgcccaggt gatctgcccg cctcggcctc ccaaagtgct
73560gggattacag gcgtgagcca ctgcagccgg cttttttaaa aaactcagca aaaagacttt
73620ggttcctcac tttctccaag gataattact tcaggatgtg gaaatatttc tgagttgggg
73680tccttagtat acagttattc tttattactg cgcagaccga atgggaaaga gaacttggct
73740gtagtgaccc tttttgttgc gttttctcca gaaggtccag tattcactct gtgcgctttt
73800gtgtgttctg tcaggcttga tcacctttat ccaaaagaat tttctcctgt gtctttcttt
73860ttagattatt tctcaagatg aagctgacag aagagggaaa gtgtatgata aatacatgtg
73920cagctttctg ttcaacttga acaatggtat gtttcagagc tgggaggcag tgagttcctg
73980agttgcatgt ggcagccttc tgccggccga gtgttcagaa acgagggtag aggtcagtga
74040ggtgaccaga aggaggatct ccttagaggc atggggggct gcttgcttga aaggaactgg
74100agcaaggaat tcctcaggga gcagatagac tagatgtgca ggaaaccgcc tctctggagt
74160cccggctgtc tgtgggtggc actatcccag catctggctg tgaaggggac gttgtgctct
74220tgctgctcac ctcacctctt gtgttcaggc agctcagcac acctcctcca gtcagtgcct
74280ctgagcgggg aaggagggga ggagcactgc atttgcaacc atcttccaga ctcccctgga
74340tattctcaaa ggactgagag gaaaggcagc tgctttcata gctgatgttc tggggtagaa
74400tgtaaggctg tgtagggatg tttctggtgg gattatgtga aaatggaggt aggcttaaca
74460tgtaagatat tcagagaaac tcttagttgg aacaagtaga ataggttttt ttctatgaat
74520gctttataga cattataatg aaaaaaacta attttaaatg tgaaaatgcc tattcgtgat
74580gtttggaaga attttgtcag attttttttt ttttttgcta tgttttgctc agtaatgtat
74640gtttatagtt gataattaat agcttttgag tcagataacc atcttgaatt ataggtgatt
74700aattttaacc tggaacaata gtgtgttctt ccaaatgtca tttcttactg aatgaagctg
74760cttgatttat ttgcttttgc aggcaaaccc tgaagaactg taaccagttg catttacaaa
74820atcataataa cttggtttac ttataactga aattattcac tgggctgtgc ttactttttt
74880ctttttagat tttgtggtgg atgcaacccg caagggtaac aaaattcgtt ttgcaaatca
74940ttcggtaaat ccaaactgct atgcaaaagg taggtacctt tgacgtgaga attggaactc
75000ccttttcagt cctgtgatga tggacttgaa tacttctggg atagttgttt gttatgtgaa
75060caagtcagtt aaccccccgt ggcccgtctt catgctcact gacaccagtg tgtctctttg
75120cagttatgat ggttaacggt gatcacagga taggtatttt tgccaagaga gccatccaga
75180ctggcgaaga gctgtttttt gattacaggt tggtaaagta catttctagc atgatctcta
75240agggcttttt ctactggatt gtgaactctg gacaaaggag ggtttttagt tctttgcttc
75300ttttgatggg tcactttgcc atgagcatta gtggggaatt aggttacact ttcctgttat
75360gtatttatta tccatttata tattatacaa ggcatgctta tttttaaaat agagtaaaat
75420ccatgcagaa agccccattt ctcaccctgc tgttgacagc tgggtgagtc ctagaccttc
75480tcatatcatg ccgcatgctg catgctcact cgtggagcgt tttccagata agtgcgatca
75540cactgtccta tagatttttc tgcaacatgg ttttacttga caatatacta tgcatatctt
75600tatggattag atctacttaa tttattgttt gctataatac ttattacaca tatcattacc
75660attttaaaag gggctgttgg caaatcgctg tctgatcacc ctgtggggat gcctgggaca
75720cgtgggccac caatggtatc tgtgtggtta ggcattaggc tgccagttga cactgtcaag
75780ctctgtggga tacatttaag tcagccattg aatacagatt taagtgcagt cagatgactg
75840tctagttaat gaactcctgt agccccgtgt acatcccatc cagaagctgt ctttgagtac
75900tgtgttcttg catattcagg ctggccttta atggctgttg cacagcagcg agctctcagt
75960gaggcagaca gggtctgagt gaagggccca ctttagcaaa ggccgctgcc ttcactccag
76020gctggctctg aatgaagagt gtggggtgga gcttccttgg gatgacccgg tggcctcacc
76080ccccatggtg ggcttcttgt gctcctctct gggtgtccgc tgcactccag ttcttgcttc
76140acctggggga gcaactggcg ggctgctctt tggccctctt tgctatggtc atcatttttt
76200ccagaccatg gttctatttt gccttcccag cgtcaggcct aagcatcctg atgtggacca
76260gccttcctgg gaccacttgc ttcagaggca taggggaggc tggtcaggct ctgggaatgc
76320ttgtagacag gtttgttcac ttcagaactt ggcagcgtct caattagatg gccagcaaca
76380cagacctatg cattgccttc tatgaatgtg ccgttatgca ggcagctgtg taattggatg
76440ggtttttttt tttttttttt ttttaaagac attttaatgc acccactatc ttcagcaggc
76500tttgttgtgt taagtctcag cacatgttgg atgggtggcc atccagcgga catctccttc
76560ctgttgtttc agatacagcc aggctgatgc cctgaagtat gtcggcatcg aaagagaaat
76620ggaaatccct tgacatctgc tacctcctcc cccctcctct gaaacagctg ccttagcttc
76680aggaacctcg agtactgtgg gcaatttaga aaaagaacat gcagtttgaa attctgaatt
76740tgcaaagtac tgtaagaata atttatagta atgagtttaa aaatcaactt tttattgcct
76800tctcaccagc tgcaaagtgt tttgtaccag tgaatttttg caataatgca gtatggtaca
76860tttttcaact ttgaataaag aatacttgaa cttg
7689473256DNAArtificial sequencesynthetic sequence 7gtgaggagcg atataaacgg
gcgcagaggc cggctgcccg cccagttgtt actcaggtgc 60gctagcctgc ggagcccgtc
cgtgctgttc tgcggcaagg cctttcccag tgtccccacg 120cggaaggcaa ctgcctgaga
ggcgcggcgt cgcaccgccc agagctgagg aagccggcgc 180cagttcgcgg ggctccgggc
cgccactcag agctatgagc tacggccgcc cccctcccga 240tgtggagggt atgacctccc
tcaaggtgga caacctgacc taccgcacct cgcccgacac 300gctgaggcgc gtcttcgaga
agtacgggcg cgtcggcgac gtgtacatcc cgcgggaccg 360ctacaccaag gagtcccgcg
gcttcgcctt cgttcgcttt cacgacaagc gcgacgctga 420ggacgctatg gatgccatgg
acggggccgt gctggacggc cgcgagctgc gggtgcaaat 480ggcgcgctac ggccgccccc
cggactcaca ccacagccgc cggggaccgc caccccgcag 540gtacgggggc ggtggctacg
gacgccggag ccgcaggtaa acggggctga ggggaccgcg 600ggaggcgggg cggggcgcgc
gggaggcccg ggcgacctca caaaggtccg cggcgaagca 660cgtggtgcgg gcccggacgg
ggcgggggtg cacgccgcgt ctcgcgaccc tccggccacc 720ccgcgagctt ccgccgtctg
cgacccggga gtggccgggg tgtgggcggc gcggggcgga 780ggaccccgcc tcgcgactgg
ggaaatggcg tctggcggcg agataatggc ggcctgggcg 840ggagcgcgcg ggcggggccg
gccccgctgc ctggaattaa ccccgctgtg cttgctcgtc 900ccgcccgcag ccctaggcgg
cgtcgccgca gccgatcccg gagtcggagt cgttccaggt 960ctcgcagccg atctcgctac
agccgctcga agtctcggtc ccgcactcgt tctcgatctc 1020ggtcgacctc caagtccaga
tccgcacgaa ggtccaagtc caagtcctcg tcggtctcca 1080gatctcgttc gcggtccagg
tcccggtctc ggtccaggag tcctccccca gtgtccaaga 1140gggaatccaa atccaggtcg
cgatcgaaga gtccccccaa gtctcctgaa gaggaaggag 1200cggtgtcctc ttaagaaaat
ggtaatgtct gggaatccga gacacataac cctaattcat 1260aaatgggatt tggggtaggt
ctttttgagt cgtgttaatg taagaatgac tcctatcatt 1320aggagtgctg ctcggaggtt
actcaccttt gggagtaata ctgaagagag gggtctgcag 1380aaaggatgtg tatgaagctt
agataataat ggctgtttcg taaactgttt gagacctatt 1440aatgaaaatg actatttctt
gctgttttta tccaacgtct gcattttccc cctttaaagc 1500tgcggtctcc tgtttgataa
aagaatattg gccagtattg cagattttaa ctgatttggc 1560tgatcctcca gggaccagtt
tctgtgggcg tgtattggag caggtttgtc tttaaatgtt 1620aaagatgcac tatcctctta
gagaaacaat cagttcaact attgttgtac tgactgggac 1680ttcatattct aatggatgtg
gcaaaagaat tgcaataaga agcagtgaac atttggaacc 1740ccaaaagaaa gttacaggta
ttgcactggg tggggaaagg atagtgtgtc tttaactctt 1800aaattgtttg gtcctatttt
ttaaaaagga aagggcccta agtagctcag atattaaagt 1860agtattctca attaccaaat
gtttcatttg aaacaattta tcttaatgaa atatagacca 1920attctctgat ctcgagttgt
ttttgtttgg atacagccct tttttttttc tttttttttc 1980ttccccttac ctttcttcac
cttggttatt tggccaggaa tacgtaaatt caaacttgta 2040catgctgatg gtagcctttg
tgaaattttc ctaattgggc cttttaaaaa catggctggg 2100tggaacattt ctgtacccta
ctggtttgac cagagcctta gtaagtacgt gcctgaaact 2160gaaaccatgt gcactttaat
ggaaggtaag ctgaacttct ttcttttcaa acctagatgt 2220atcggcaagc agtgtaaacg
gaggacttgg ggaaaaagga ccacatagtc catcgaagaa 2280gagtccttgg aacaagcaac
tggctattga aaaggttatt ttgtaacatt tgtctaactt 2340tttacttgtt taagctttgc
ctcagttggc aaacttcatt ttatgtgcca ttttgttgct 2400gttattcaaa tttcttgtaa
tttagtgagg tgaacgactt cagatttcat tattggattt 2460ggatatttga ggtaaaattt
cattttgtta tatagtgctg actttttttg tttgaaatta 2520aacagattgg taacctaatt
tgtggcctcc tgacttttaa ggaaaacgtg tgcagccatt 2580acacacagcc taaagctgtc
aagagattga ctcagcattg ccttcattcc ttaaaattaa 2640aaacctacaa aagttggtgt
aaatttgtat atgttattta ccttcagatc taaatggtaa 2700tctgaaccca aatttgtata
aagacttttc aggtgaaaag acttgatttt ttgaaaggat 2760tgtttatcaa acacaattct
aatctcttct cttatgtatt tttgtgcact aggcgcagtt 2820gtgtagcagt tgagtaatgc
tggttagctg ttaaggtggc gtgttgcagt gcagagtgct 2880tggctgtttc ctgttttctc
ccgattgctc ctgtgtaaag atgccttgtc gtgcagaaac 2940aaatggctgt ccagtttatt
aaaatgcctg acaactgcac ttccagtcac ccgggccttg 3000catataaata acggagcata
cagtgagcac atctagctga tgataaatac accttttttt 3060ccctcttccc cctaaaaatg
gtaaatctga tcatatctac atgtatgaac ttaacatgga 3120aaatgttaag gaagcaaatg
gttgtaactt tgtaagtact tataacatgg tgtatctttt 3180tgcttatgaa tattctgtat
tataaccatt gtttctgtag tttaattaaa acattttctt 3240ggtgttagct tttctc
3256818907DNAArtificial
sequencesynthetic sequence 8ggcggggcct gggaggggac aaagccggga agaggaaaag
ctcggaccta ccctgtggtc 60ccgggtttct gcagagtcta cttcagaagc ggaggcactg
ggagtccggt ttgggattgc 120caggctgtgg ttgtgagtct gagcttgtga gcggctgtgg
cgccccaact cttcgccagc 180atatcatccc ggcaggtaac ctcaggctcc aaggggcggc
cccggtccct ggctgtggag 240gggtggctct aattccgcag aaggcaggaa tggggtaaag
gaaaaaagcg cagatcttgg 300gtgtggaggg agtcaaggcc tgcgtgcaaa gaagggaaca
aatccaggta ttgagaatgg 360gaaaagaaaa gggaaggagg ggatgctgga tgcttggata
tgcagaaggt ctgcttttgg 420gcctgggagg gagaaactgg gcggtgagga agttggatgc
aacgacaagg ggaaaatcag 480gtctgcactt gggttggaaa atcgaggggt ggaagttgca
agaatgcatg tagaagacta 540agcctggagt gtaggaggaa gaaaacgtgc agcagctggg
ggctggatgc aaagaaggct 600gtaagccgca gacgggcgtc tgcaggcaac tcaggcggcg
aggaatagcc ttgaagccga 660tccctcgcgt ccgccagggg gcgtggaggg gcggagctcc
agcggccttc agaggggtcg 720ctaggccaca cggggcgaga gggggctggg ggaaacaccc
ccgccagttc cgggtgcctg 780gagtttaaaa ggtcccagca ccagcgaggg gaggggaggg
gaggggcggg cgtggagacc 840tggaaggagg taccgatcca gccttgattg cagccctctt
gcacaacggc cataaggacg 900ggtgcaggcc aagagcaagg acatgcaaac cccaagacct
gctaacgggc ggcgaagcgg 960gggcacgccc tcgcacacgc agagataaat tgtgctccca
tgacctttat ttggaaagtg 1020cctgcgggcc taaaattggc ctttgtccca ccgagtacac
tcagcactgt actttaaacc 1080ggataaactg ggctgtctgg caggtactaa aaacagctaa
attctcctgt gagtgttctg 1140tatgttaaca cttttattcc ttgttttgtt ttaggcgata
aactacattc agttgagtct 1200gcaagactgg gaggaactgg ggtgataaga aatctattca
ctgtcaaggt gagaattagc 1260aaattttccc ccttcttctg tactttcttt gatgtggcag
tacagtgttt aactggtctt 1320gggggcaggc cgaggcactg caagggaatg agtgaggaat
atttccaaca acgaattcca 1380acagcttcct tgtttctttt aatacagtgt cttatctgca
agagatcctt tttgcccaga 1440aattattgta gttcatgaac tcggcaaaaa acaatctggc
caaaaacttg aggttgatga 1500aaataatatt aaatggctct tttttttcat taaactactc
tgtattgtta ttccaggttt 1560attttctgga attgcacaat tatgttagga gataggattc
agctacttca tatgagctgg 1620tgcctgctgg tcttggaaca gcccttcctt ctgaagttgg
gattgggttg gagacaaaat 1680ctgaggggca acaaaggtgg agaagtcagt ccagtggggc
ctcaagccca tcccatggaa 1740atcagatcca gaagaaatac aattatgttc cacatggtag
taacaataaa gcttcactgt 1800tttagttaaa agatggtaaa aatttcatgg ctaagtaatg
tgaggaaaac ctgaagcgtc 1860tgaagtatgc attatgagat aaagaaagat tactgcagag
agtacagttg ctttaactga 1920gaaggaaata gtgaactaaa aagatatcag tcttcacatt
ttaggtacaa tatttgacct 1980ctattaactg tatttgccat caagaataaa ttgccatgtc
atgactgttg catcatacta 2040tatagggaca tggccatgga agtgtattat caggaaccag
ataagttcac tgcctccttt 2100tttgctttgt tttaaaacaa ggataggtgt gacagtggaa
tcaaacatga actgaatcat 2160atgctttcag ctgtactaca aattatactt gacattacaa
atgggaagta attgactcat 2220ccacaccatt ctgttcattt cttttagtct agttcagttc
cagaaggttc ccccaaagga 2280atctcctaaa cactagtaag aagaattcta gaattgcgaa
tttgggaagt gaaaatgggc 2340ctggggattg gaaatacatc caggcttgtc aagaaacaga
cgcttactgt ctactaatca 2400ttacattttt atttaaagac caaattactt tagctcaatt
tttcaagaaa gactatttta 2460ggcttcttat ctaataattc tttaaagtca attctcttga
cttttttagt ccttaagaga 2520ataaaagcaa tttgcagctg tgttgttgga ttaaaaaaga
gtttcgatta gagcatcatt 2580agaaggaata gataactttt agcaggctca gagcttcttc
tgcctctagg gacaagctgg 2640gacagtttca tttcttccaa agcgtccaac cttgcacttt
ctgagaatca gattgatttg 2700tatatgctac ccccacaccc tatccttaaa gtgctgtctt
cctaggacaa tgcacagttt 2760gtcctatccc actcactagc agcttaccct tgcctgtgaa
cagccagaag aagatgacag 2820ggacatgctt gggtcctggg cagtggccct actgtataga
gattcttcta attgagaaat 2880cactttgttg tatttagccc cacatctcca atgtctgtgt
tatctctagg aaaacagttc 2940caccaggaat tcttcgtctc gcttttagac ttaaagtttc
cctgaatatg ggtcacagga 3000accagctgaa tctcctcatg gctagttatt tttattaaat
aacaaaaaca gcctcttaaa 3060ggaggagaaa tgctagcact caccattctg gacatcttga
gagcccagta aaatgatgag 3120ttggactgaa gtgttcaata aacatgagat tgtggaaata
atctcatttc ttaagacaaa 3180ccagtagttg agaataatga ttgcattatg aagggcacgt
tatagggtca ggctctgcca 3240cgctctagct aggtggcctt gggaaagctc tttttttttt
aacaaagtaa aatggggaaa 3300tgatggccat ttttttggat tgttatgagg gctagctcag
aaaccgcgtg tgaaacataa 3360cacaatactt tgttcagaga agatactcaa ttctaatggt
aaatagaatt gctgttacta 3420gctttttatt caactacaca taaattgaat tgcatgaatt
gttcttttag tagtcactac 3480gttgtttata taaacactac gttgtttata tatttcactt
tataatgaaa taaatgacaa 3540ggcatgtatt ttttttttct ttttaggttt attgaagtca
aaatgtccaa aaaaatcagt 3600ggcggttctg tggtagagat gcaaggagat gaaatgacac
gaatcatttg ggaattgatt 3660aaagagaaac tcatttttcc ctacgtggaa ttggatctac
ataggtaaat gagttacccc 3720tccgtgtagc aaactcagaa aggataatct ggctgggcat
ggtggtgcac acgtgaagtc 3780ccagctactt aggaggcaga ggcaggagga tccctcaaga
ccaggaattc aagtccagcc 3840tgggcaacag agtgagaccc catcacttta aaaaaaaaag
gaaaaaaaag ggaaggagaa 3900acaggaaaaa aaaaaagaat ataatctgaa ttattttgag
gtgaagttag ctttttttat 3960atagatatag ctgtgttttg tgaataaagt ttgttttaag
cctaaatata ttcagatgaa 4020tcttctaatt ttaacatact gctagaaaaa ctggatttat
catctaaaag tcaagaatta 4080taagggaaag aatgattttc agattcttct aaccttctgt
ttcctgtgaa ggttttattt 4140gtaataaaac agtggctaag aatagtacaa tgtattgaga
aaagggaaat aagagaggat 4200gtaagaaaca gtaaactaaa tgcagttaac acaattttgt
catttcaaac tcaattttct 4260atcactttac ttagtcaatg gacctgtttc cttttcatgc
ctcacctttt gcccttttca 4320tacaattgta gtgcagaaag aattcatgat gtttcttagt
tgaacccctc ctttccagca 4380aaattccctt aaatcctgtg tccctttgcc ctgtgtgtaa
agtgcctggg gacagatgca 4440aaagtctatg taattctctc atttttttcg ctgtgttttt
cataaacttg cttctgttct 4500ttgtaccttt aggtagagat agaattttta aaagggtaaa
gtggctgaag actggcatag 4560aaaaatattg agcaacacgt ttcagccaaa ctattggcaa
ctctaagtgt gtttgcctca 4620gcccagaatt agtcatcaaa atttgtccta aggacctgtt
tgagtggaga catttaattc 4680acataatgtc attaaacata ctttttaatt gttctaaacc
taagctgctg atgtctatat 4740tgaaatcatg ataagatata aatacttgca gaagtcaacc
aaacataaga aattaggcat 4800aaaaacatct tccaactagg ttaaaaaaaa aaagcatctt
aggaactcct gtttcaggac 4860tttacatgac agtaggtgaa ctggcagggt tcttttcctt
ataatggctg caactaaaga 4920tgctttgagc ctctttagtg tggaatcatg aggagtttta
aaggggagtc actatgacta 4980ggaggaaaaa atttggtggc tgcagactag ataatttttg
gaggctcaaa caagttttaa 5040atttttccaa aattcctatt attatcactg actggttctt
tttcaggaga atggagcagg 5100tagtttgttt tatgtaggct ggacagtggt ctgggcaatt
tgttccttcc tttcttatct 5160tcttagaaat gttaagaaga caagcaaaaa atctaataat
ttgctgatag attctcctta 5220tgagaaatgg ttcctaggaa cttgaaaact actgatcata
cttcctgttg gagttgggat 5280tggatcaaca tttcctatgc aagaagataa caaaggacat
gactttgtta gatttatatg 5340aattatctaa agtcgaagca gttggaagtt atttttattt
ggaaatatgt caagattact 5400atctctttgt ttgcatcatg agttgggtag gagatctaag
aaaggaagat aagggaacca 5460aaaagaaatc tagaggcagg ttttaagagc tgaaaaacct
tttaaatcct tggagaacag 5520aataaacaaa acattatttt gttttcttgc tttttaacaa
actattgcat gcttcaaata 5580aagctttgca gtcattttct atgctccctg gacaactaac
attctttcag ctctgaatga 5640cctgcaatct ttgtgttggt gtatattaag ctattactct
ctggtatgta gaaaaccatt 5700gatggattcc tttacttacc caataaattg taggcttgtt
tccagagcaa acacttgctc 5760aagaattaca gaaggaatta gctgggcatg gtggtgcatg
cctgtagtcc ccgctactgg 5820ggaggctgag gcgggggaat cacttgaacc caggaaggca
gaggttgagt gagccaagat 5880cgtgccactg cactccagcc tgggcaacaa aacgagactc
atctaaaaaa aaaaaaaaaa 5940gggaaaggct cattttatga ctaactggca ttaatgaagt
agtcattcgc atttttggca 6000tcaactgtca catctttacc tcccaccact tcaacgtcaa
aatacaaaaa atcctttaac 6060ccctcccacc cccttttatt tttaaagagc aatatttact
aagggaaaaa ggtggtcctt 6120agacttacac ttattatact aattatatgg agagaaacca
ggccattatt gcctctatct 6180ggtgaaaaac aggaggcaaa gggcagagtt tgatggtttc
cattcatttt cctgatagac 6240agcttcccat tacaagagga ggggcagccc agcagtctag
cctctcttag ttctctttgt 6300agttggcacc catcttctgt gtttagggtg tgccagtgct
aaaacttggc agattttggt 6360gtactcagag ccttcgcttt ctgcataatg agctctatat
gccatcactg cagttgtagg 6420ttataactat ccatttgtct gaaaaacttt gcttctaatt
tttctctttc aagctatgat 6480ttaggcatag agaatcgtga tgccaccaac gaccaagtca
ccaaggatgc tgcagaagct 6540ataaagaagc ataatgttgg cgtcaaatgt gccactatca
ctcctgatga gaagagggtt 6600gaggagttca agttgaaaca aatgtggaaa tcaccaaatg
gcaccatacg aaatattctg 6660ggtggcacgg tcttcagaga agccattatc tgcaaaaata
tcccccggct tgtgagtgga 6720tgggtaaaac ctatcatcat aggtcgtcat gcttatgggg
atcaagtaag tcatgttggc 6780aataatgtga ttttgcatgt tttttttttc atggcccaga
aatttccaac ttgtatgtgt 6840tttattctta tcttttggta tctacaccca ttaagcaagg
tatgaaattg agaaatgcat 6900atatgtataa ctgtatattt acacacattt agctaaaggc
aaatacaaat aaacttacaa 6960ataggcgtcc atctcaacac attttttttc aaacatgctg
ttttttttcc tttatccttt 7020tattcagtta taccatatga tattgccatt tttatgttgg
taatttcata tggttcaacc 7080agatctgtgg ttttcaacac tggctgcaca ataggatccc
cttacaagtt tttttggtgg 7140ttttgttttg ctttgcttga tttgtttctt tgttttagtt
tcaatgcttg agtaccaccc 7200tacacaaatt aaaatctgaa ttccatgggg ttcaggcatt
ttaaagctcc ccaggtgaat 7260ctaatgtgca aacttgagaa ccaccaaaga ttgtattaaa
catgatccca tcatgcataa 7320aagaaaaaac tggctgggta ctatggttca cacctgtaat
cctagcactt tggaggccaa 7380tttggaagca ctgcttgagg ccaggagttt gagactagcc
tggacaacat agcagaaccc 7440tgtctctaca aaaatgaaaa gtatttcaat aattatgtca
attgttcatg gaagagccag 7500ttttgtttat tcatatacaa agtgagtagg cgaagctgag
tggggtggca tgtgcctata 7560gtcccagcta cttggaaggc tgaggcctga ggatccctta
agcctaggag ttcaaggtta 7620cagctatgag ctatgatcac accactgcct acgcaacaga
gcaagaccct gtctcgaaaa 7680agaaaaagaa aaaaaaaact gactcggtag ttgaaagcag
ccttactaaa gcattccttc 7740ctgcctggaa aaaaagtatt gcttctttac ttctgtacca
gtacacttgt tgccaaatta 7800agcaaaaaaa ctgccaagta aacaaaatca aagttcagtg
ttgaaactga ggtttcagac 7860tttcacagaa agtagtttat gtcttaaaag gaccttaaaa
acaggaatct ctcatgctga 7920aatccagagg ttttaatgta gccatcattg aaaacagtgt
gttgagggta aacagtttag 7980tccttgaggg gtcagttaac tttgttccac tctgtggcta
aaactatcct ttcatcctgg 8040ccaaagcctt cagaaatagc tcccaggggc ccaagcaagg
gaaggtagat ggcagtggtg 8100caaactcgct aatcttgtaa aaatcaccct agattctttc
cagttcagtc gtgccttttt 8160tctgcgtata tcctttttgt tttttgtttt tgagacagag
tctcgctctg tcgcccaggc 8220tggagtgcag tggtgtgatc ttggctcact gcaacctctg
cctcccgggt tcaagcaatt 8280ctcctgcctc agcctcttga gtagctggga ttacaggcac
atgctaccat gcccggctaa 8340tttttgtgtt tttagtagag acggggtttc accatgttgg
tcaggctggt ctcaaactcc 8400tgaccttgtg atccgcccgc ctccgcctcc gcctcccaaa
gtgctgggat tacaggcatg 8460ccaccatgcc cggccttcct cttttttttt ttttttttaa
ttattttggc atcagtcatt 8520tgtaaaaatg gccattctat ttattaaagt ccagaaagag
aatttcaaac ctcaggttga 8580ttcatggact gtttaaatat acataaacct atacaaagca
tttatggtgc tttggtacct 8640cagtttctcc cttttcagaa atagtaataa attaccaccc
atatttactt tatggatttt 8700atatgtcaaa aatgttctgt gtaaagtagg tgtttaatct
ttattgttac ttactgctct 8760tttaccagtt gttattagta tttctctaca cttatagatg
tggccggcac ctgctggtac 8820ctaactctgc aagtatctga ttcaattcat tgaagaagat
acaatgcagc aaagacttat 8880ggatgtctag tatatgccag gcatattatt ccactgagta
gctgaggccc atgagggagg 8940tgcctgtcct tgaacagccc tttcctaaaa atcatcatca
tcccattgta gctgctccca 9000gaatgatttg attgctccat atgaacaagt cctataacac
tagtaacaat gataccatga 9060gagaccgagc cccgatggcc taagtaagga cgagacctca
agtcctttga ccctggatgc 9120attatttcta ctatatcata gttccctcct tgtaagactg
atgtaagaat caaatgagat 9180tatgcaagtt aagcatttaa agcatctggc atagagtaag
gacaaagcat tagctacctc 9240agtactacaa ttagtattgt tatcatcacc ctctagggag
acttccctga cttccttcca 9300tggtcacctc ttttcctctg tcatcctata gttttttttt
ttttgggggg ggggtctaat 9360accctctttt ggcatttgaa agctcttata ttgcttttca
cttatatatg tctttatagg 9420gttgtaaact tcctaaagga aagtggctta tgttattctc
tgtcctcttc aaatcagtgc 9480tcagaaaact ttcctatacc tcgtataggc acctaataaa
tatttactga tttaggggaa 9540tgtctggacc tcttcatccc catctcctaa aaaaaaaaaa
aaaaaaagaa gtttgacata 9600ctgccctatt tgtctaggtg tcttctaggt ctatattata
tgaatattct ccttacaatt 9660cctgctaggg tatttttttt ttctttatac ctttttcccc
tctacacagt acagagcaac 9720tgattttgtt gttcctgggc ctggaaaagt agagataacc
tacacaccaa gtgacggaac 9780ccaaaaggtg acatacctgg tacataactt tgaaggtatg
tatgactgta gcataagctt 9840cttttttttt taaacaaatg atttagataa tatttttatt
gctttttttg ttagttatgt 9900gactgcctaa aaatataatc tgaatctaca gtgtttttgc
aaaacccgaa acttgacata 9960aagaagtaat ttgcttccat accttcctgt ggcatgaata
aaggcacaaa agggttaccc 10020acttaattgg aaatgccttt aggcaaagac aaggagatga
ttatgcattt atcttaaagc 10080acagagagaa ggttggcaga aatctgctgt gcatgaatta
tatacattaa atattaatat 10140tctcaaatca cccagcatat aatcctgccc tttgctctgg
tagggctctt gtatctggaa 10200gaggtttcct tatatatttg ctgaagtttt cttcttgccc
ttctgggtat ttatcctgtg 10260aaaaagtaga acatttgctt tttgcctttt ctttcccagc
taccctgcta cctttgatgg 10320caaatcccac ccaaaagttg ttgaaataat tagtgggccc
ttttccttca ctattgaagt 10380tgttgaaagc actcacacaa acaaaaatac ccaacactca
cctacctttt gtttttcttg 10440cctcttccaa ataatatctg ttggaatctg gttctgcagg
cttcagcacc tttcaccctg 10500aacccaagtt aaccctgagc attggcatgg attcaagttc
tatctttaag taataacaaa 10560gttcaataat agttgtaaaa cacagtgatt acatgtagca
taattatttc tacttatttc 10620taccaactac agtaggagtg ctcagtatcc tccaggagat
tataagaatt ttcattcagt 10680atttgaaatt taagtttttc tcaataactg aggattgagt
acacccctaa agtttaaaat 10740agatgttggg aattgtaaag gtagggtgtt tgtccattct
tgcgttgcta taaagaaata 10800cctgaggctg cgtaagttat aaagaaaaga ggtttaattg
gctcatggtt ctgcaggctg 10860tacaagcctg gctccaacac ctgttcctgg tgagggcctc
aggaagcttc caatcttggc 10920agaaggcaaa cagacaatag gtgtatcaca tggcaagagc
gggaacaaga gaaagagaag 10980ggggaggtcc cagactctta aacaaccaga tttcaagtga
attaactgag cgagaactca 11040cgtaatcacc aaaggggatg gtcctaagcc attcataagg
gatccaaccc catgttccaa 11100tctcctccca ctgggcccca cctccaacac tgggaatcac
atttcaacat gagatttgga 11160agggacaaat atccaaacca tatcagtatg taaaagaagt
ttcaaaatta tttgcctttt 11220cttaaatgta tttctggttc atatcagttt ttggcatttc
tgcatcttca ggattttaaa 11280gactgtatgt tttttcattt ctgctgtcct tccaaaacaa
gttagaatgt ccttatctag 11340aactggcttt tctctcatta tgtgcctcag aaatttgttg
gaaacctgtc tgggacttct 11400gaaatctagt ctcagatgtg agagctgaga agtaggtcat
ttggttgtgg tgggtgattt 11460tagccttatt acaactacat tacatttatt cttctccctt
ttttcctctc actggcttct 11520cctctacaga aggtggtggt gttgccatgg ggatgtataa
tcaagataag tcaattgaag 11580attttgcaca cagttccttc caaatggctc tgtctaaggg
ttggcctttg tatctgagca 11640ccaaaaacac tattctgaag aaatatgatg ggcgttttaa
agacatcttt caggagatat 11700atgacaagta actatagttc ttttttaact ttttctttat
tctcaagtaa gctgacattt 11760gcatatagag tatgtatctc cctatcccta tgattctggg
taaattgagt gaaaatcatc 11820actgtctctt aaagataagg gcaaaactga ggtttagcag
gagtgaaaca aaaccactct 11880gacttgcttt tataagataa acatgttctt aaataaggtc
cccacatgaa ttgttttcag 11940agccaggttc tttaatgttt aaataaacgt acgctgttag
tgataagttc taatttttca 12000tgtgtgagtt tctaagtcag acccatttcc attctttctg
aagcccattg ttagaattta 12060aaattctgtt ggccaggcac ggtggctcat gcctgtaatc
ccagcacttt gggaggccga 12120ggcgggcgga tcacgaggtc aggagatcga gaccatcctg
gctaacacgg tgaaaccctg 12180actctactaa aaataccaaa aattagccgg gcgtggtggc
gggcgcctct agtcccagtt 12240actggggagg ctgaggcagg agaatggcgt gaacccggga
ggcggaggtt gcagtgagcc 12300gaaatcacgc cactgcactg cagcctgggc gacagagcga
gactccgtct caaaaaaaaa 12360aaaagaaaag aaaagaaaaa aaagaattta aaattctgtt
ttagtggagt catttgaact 12420taagtctaag tttataacaa cactggcttc cacagcacag
gaggtgagca tgtgttaata 12480tttaagattg gcataactcc ctttaggtgc aagtgttcag
gccaaaatgt tcctgaggca 12540ttttgattcc tcctcctgct gcccatctat accaagccca
gaaactgtct ggaatatatt 12600ttagtttcct gaatgacacc aagaagtaga acagtctttt
caaaaatgta ttttaaaaat 12660aagctgaatc tcaagaatct gatctatagt ataatgaaaa
ctgaaaagtg aagtagtcat 12720tgggatactc tactgtctca cttaattctc acggcttccc
tgcaaggtgg gtaaaattgt 12780tcctacagat agtcaaattg agttttacag ttagaaaatg
attgggctag gatttgagcc 12840aatgtctgtc agattcctga gtttctgcta cttctactaa
aatatgctgc ttcttgtgtg 12900tccggtcttc tgtttgggac aagcagatga tatccctaac
aaaatcaatt ttctttatta 12960ttattctctt ttaccttttg tttcccaggc agtacaagtc
ccagtttgaa gctcaaaaga 13020tctggtatga gcataggctc atcgacgaca tggtggccca
agctatgaaa tcagagggag 13080gcttcatctg ggcctgtaaa aactatgatg gtgacgtgca
gtcggactct gtggcccaag 13140gtacagaggt ggagcctggc ctgtaggaac agggtcattc
cagggtagtt ctctaatttg 13200ggaaggggag ttttgtagtc ctttgttgta aaatcttgga
atgttaaacc tccaggtcca 13260ccgtcttacc tgacagctaa ggaaattaag ctcagactag
agaaatgatt tactcaagac 13320cacatgggaa gtaaattagt ggattgacac tcctggctcc
agtgtcactc cttgaagttt 13380taaagcctac ctgatctgaa aatcactccc tttccctgcc
ctccttgtcc tttggtgaaa 13440atgtaaaaaa ccagggcact caggcaagga gggataaagt
gaggagcttg atcatgtcat 13500aaccaagctt tggtgcctgc aaagctcatt tattgggcag
caggacctac tcatgtccct 13560ctgccagctg ctgttctggt agaatataaa acaaatgtgt
ttggctgggc acagtggctc 13620acgcctgtaa tcctagcact ttgagaggcc aaggcagtgg
atcacttgag gccaggagtt 13680caagaccagc ctggccaaca tagcaaaacc ccatctctac
ttcaaaaaaa aaaaaaaaaa 13740aaaattagcc aggtgtggtc gcatgcctat agtccctggc
actcaggagg ctaaagcatg 13800agaatttctt gagcctggga agcggaggtt gcagtgagct
gagatcacgc cactatactc 13860cagcctgggc aacagagcaa gactcttgtc tcaacaacaa
caaagaaaaa gtgtttttgt 13920ttactgctta gcttacacac aaatcaattg agcaaagaac
cctaggggct gtttacagaa 13980attccaggag aagtttcatg catggggtaa gggccaaatc
aacagaaaca cagcgcctgg 14040tttcctcagc accaagttgc ccttcagttt cagttgccct
tggtagctgt atgaacttga 14100atctccccag atgaatgttt gttaacttta attatgtttg
tttttcccaa gaagtactac 14160tttttctgtc tcttatcagt gttaaacatc tcctctcagt
ttgaaaatca gtagatcaac 14220ctggttaaag ataacttttt gccagataaa tgagttacac
aactctcctt accatccttc 14280tgtttctcta catcctcaca atcatttgta ctgaatgcaa
cagaggaagg agtgttattg 14340ctttgtgatg actccgtggt tgattattaa cttcacaggt
gatgttggga ggtagcaaaa 14400atggagaaaa gaagaaaatc aattatatag atataagagt
tgtaatgtgg ttctttcaat 14460aagaaaccac agaagagaac tgttgtactg agggtatgaa
agagagcgag gaagggcaac 14520tgggatgttc ttagatccaa ccgatcctgt gtttacctgc
cttctcttcc cagtcccagc 14580aagtgtatga gcagcttgag ggttcttaag agacagctct
cgtccatctt tatttcccca 14640gaacagcaga gcattgcaca taagaataac aataatagat
tgagctctgt gtccagtact 14700attctaagga atataaatat atattcatat atatttatga
atatatgtat atttatctaa 14760tcccacagca acctagtgaa gtaggtgctg ttattactcc
cattttacag ataagaaaac 14820tgagccgcag tagctatgaa gtcatagaac tagagtggaa
tgtaggcagt tggaccctga 14880accctccatc aaggagtagg tatccctgaa ataagtgagg
ggaaaatgca gcctttccag 14940acccattggc tctgatatct ggagcgggga tcctgccttc
tgaaaggcag aattattggt 15000gattccatgt gctcttgttt actttgctta ccaagaccta
tcaagattga gtcatttatg 15060ctctcatctc tgagagactc agtgctcttc atgcagttgg
acccaacgct tcatgctcca 15120ctacttacag ggtatggctc tctcggcatg atgaccagcg
tgctggtttg tccagatggc 15180aagacagtag aagcagaggc tgcccacggg actgtaaccc
gtcactaccg catgtaccag 15240aaaggacagg agacgtccac caatcccatt ggtaagatgg
tgtttacatt gatttctcac 15300cagagagtgc tctccaaagc agcccagatg tgttcccttg
gctgctcagt gttttgtgtg 15360caaagtcatc accaagtagc tgatttgttc tactagtaag
atctatttga atatgcttct 15420taaaatatac aatatttgct tttctgtttt gtgggagaac
ataggttaca gagaggaatg 15480ttatcaacaa gcattttcct ttacctctgg tgcagtgaaa
tgtcacataa ggctacaaat 15540ctaaaagtca catggataga tccttttaac aagtttcaaa
gatagcactt caaaaagaga 15600ttacagcctg gaaaaaggag accaatatag acaagagata
gaagagattg tgaccttttt 15660caaattagaa aatgccttaa gtttcaaaca ctagtaccat
gccatgaaaa tgtgtttttt 15720taaagtttct gtttggtaaa atatttctaa ctctcctaaa
acttctagcc catgtggtta 15780gtatctaaag aagtctgtca cctaaacaaa aaactattct
gttttgggga actatgagac 15840atttggaaac ctctataact aggatgattg gagtgttgtg
ttttttttcc cctcttttag 15900cttccatttt tgcctggacc agagggttag cccacagagc
aaagcttgat aacaataaag 15960agcttgcctt ctttgcaaat gctttggaag aagtctctat
tgagacaatt gaggctggct 16020tcatgaccaa ggacttggct gcttgcatta aaggtttacc
caagtaagta taagatgccc 16080tagtttctat ggtcaaatta acacttatcc tcactgggct
cagagcatcg gtgctttctg 16140gaattatata aattgttatt catcatctag ttcaggagtc
agcagatatc tgtaaattgt 16200cagatagtga acattttagg ctttgtggaa catatagtct
ttttgcaact acacaactat 16260tcaactttgc ctctgccatt gtagcaggaa agcagtcata
gacaatacag aatcaaatgg 16320tgtggctggt accaatcaaa cttttatgtt caaaaccagc
ctcgatttgg ttcatgtgct 16380gggctgtaat ttgctgacat cccatctagt tgataatcat
tgaacgaaaa ggttctattt 16440aattttaaga agcagattat agacaaatag aaacaaagat
acttcagagg ctattttatt 16500ctactccttt attttcttta acttactgat gagaaaagtg
agcagcacaa gtttaaggtg 16560tgcaattgat tacagtccct taagtatctg taaccaatat
ttgggcaaat atttgacagc 16620ccatatgttt actgagaatt tttctgagaa catagtagcc
agtatcctgg ggggattgtc 16680tccatatctc aaccagtgca tctgcagagg tcccaggtag
ggtcagtata ccccataatg 16740gggatatact tggtcactgc atgtttctta atttaaattt
ccaacaagat tgcagtgttc 16800gctgggtgct gtggctcatg cctgtaatcc tagcactttg
ggaggccgag gtgggtggat 16860cacgaggtca ggagatcaag accatcctgg ctaacacagt
gaaaccccat ctccactaaa 16920aatacaaaaa attaaccagg cgtggtggcg ggcacctgta
gtcccagcta ctcgggaggc 16980tgaggcagga gaatggcgtg aacctgggag gcggagcttg
cagtgagccg agatggtgcc 17040actgcactcc agcctgcgtg acagagcgag actccatctc
aaaaaaaaaa aaaagattgc 17100agtgttcaaa atggtcttat cagtggaata cctttgtagc
ctatttaaca ggcacctgtc 17160agcaggatta tgttatcctg tcttttgttt ttcttttttt
ttctttttat tgagacagag 17220tctcgctttg cccaggctgg agtgcagtgg cgtgatcttc
gctcactgca acctccgcct 17280cctgggttca agtgattctt ctgcctcagc ctcccaagta
gctgggactt gtgccacaac 17340acccggctaa tttttttttt tttttttttg tatttttagt
agagacgggg tttcactttg 17400ttagccagga tggtctccat ctcctgacct catgatccac
ccgccttggc cccccaaagt 17460gctgggatta taggcgtgag ccaccaggcc cggcctgtct
tttgtttttc ttaagacact 17520gatagaaata acaacattat aacttttttt aaggacatgt
aacggtttgt gggaaggtgg 17580gtaaaggttt ggctatgccc tgaataagtt ttgttatgtt
taagaatgag gaagaagtgt 17640gatgattttg gtctcagcag cattagtctg aaccgaaact
caatgataat ttcaccccca 17700aagctacata gcaagaaacc taactgagta tgtatggctg
tctctactgc cggttgccta 17760gagagcctga gtactgagcc tgggtcagcc ccaggaaccc
tgaacatagt cattgtctat 17820agattttgta gcttactaac atgaatgcgt tttcttccag
aaacaaatag aatactattt 17880taagtagcat ttctaggact ttaccactac ctgctaccat
atcagagacc aactaaattt 17940tctttttttt ttccttcccg ttagtgtgca acgttctgac
tacttgaata catttgagtt 18000catggataaa cttggagaaa acttgaagat caaactagct
caggccaaac tttaagttca 18060tacctgagct aagaaggata attgtctttt ggtaactagg
tctacaggtt tacatttttc 18120tgtgttacac tcaaggataa aggcaaaatc aattttgtaa
tttgtttaga agccagagtt 18180tatcttttct ataagtttac agcctttttc ttatatatac
agttattgcc acctttgtga 18240acatggcaag ggactttttt acaattttta ttttattttc
tagtaccagc ctaggaattc 18300ggttagtact catttgtatt cactgtcact ttttctcatg
ttctaattat aaatgaccaa 18360aatcaagatt gctcaaaagg gtaaatgata gccacagtat
tgctccctaa aatatgcata 18420aagtagaaat tcactgcctt cccctcctgt ccatgacctt
gggcacaggg aagttctggt 18480gtcatagata tcccgttttg tgaggtagag ctgtgcatta
aacttgcaca tgactggaac 18540gaagtaggag tgcaactcaa atgtgttgaa gatactgcag
tcatttttgt aaagaccttg 18600ctgaatgttt ccaatagact aaatactgtt taggccgcag
gagagtttgg aatccggaat 18660aaatactacc tggaggtttg tcctctccat ttttctcttt
ctcctcctgg cctggcctga 18720atattatact actctaaata gcatatttca tccaagtgca
ataatgtaag ctgaatcttt 18780tttggacttc tgctggcctg ttttatttct tttatataaa
tgtgatttct cagaaattga 18840tattaaacac tatcttatct tctcctgaac tgttgatttt
aattaaaatt aagtgctaat 18900taccatt
18907919460DNAArtificial sequencesynthetic sequence
9gtgcccgcgc ggccagcgcc cgccaggccc agcgttagcc cgcggccagg cagccgggag
60gagcggcgcg cgctcggacc tctcccgccc tgctcgttcg ctctccagct tgggatggcc
120ggctacctgc gggtcgtgcg ctcgctctgc agagcctcag gctcgcggcc ggcctgggcg
180ccggcggccc tgacagcccc cacctcgcaa gagcagccgc ggcgccactg tgagtgccgc
240gcggagggtc caggcaggcg cgcgccccca gctgcgacgt ggcggcttcc caggctgggg
300ccgggaagca cgtcccgcca gcccgcagcc cggggacggc ggggtcaggc gcacaaaggg
360ccgcggggca gcttcgctcc gcgctccccc gcccggcgct tcccggccgt gccaggcgct
420ggggtgggga cttgagggac ggtggcaact ggtggcccgg gcgacggcca gctctgcgcg
480ggcgggggct cggggctgcc gcgcgcccct aggtatttcg ggagggggtc ctgagagtgt
540cccggacccg aagggtggcc tgcccgccct gcgcccctgg aacgagacga gcacccgtgg
600ggggctggag caccccgcgc gctcccctgg cgagagggag ggtcgtggct cggcccctgc
660tcagacaaag gctgggaggc gggagacatg cacttcccct tccttttcag ccaggcgcgc
720gctgatacca ggcccacgtc agctattttt ggagcctttt acacgacagc tggaggagcg
780tcctttttaa ttttcccctt ttgtttggcc gcccccaccc ccaccccttc gccttcatcg
840ctgcacttga ggctccatcc tggggcctct ccttgacttg acctgccttg gcaggcacat
900gccctccctg cctggctcac tcgccgcaga gacctggcag cccgcgcaaa atgtcacttt
960gcggaatcgt tcccacggct tctgggtacc cttagttccc tgcttaggag ggaagacagt
1020agtcgggtcg taataagcaa gacttagccc gagcctccgt tgccaacgca ggctgccttg
1080cttggcgtgt gggcatcggc ctgccccctc accctggcta cccaacacag ctacaaaagg
1140cagggaacaa tgtaggtccc ttggccctgc ctaatgcctg ttgccatgga aacccctatc
1200ctaatctggc caggagcccc ttgcagtgag ccaggagagt gaggaagagg ggatggggcc
1260cgctggccct gacctggcca gaggaggtaa tggttaaccg gattgtggga gcagctgact
1320agagccgggg gggtagggag gcttgggccc cagtcctacc ttccctgcca aggagaaagg
1380ggcatgtctg cttttgtacc tctgggaatc tacctcaggg atctgcccaa caactcccag
1440gttccaagtg ccccaggacc caaagattcc catatagcac accaccttca gcaaaaatat
1500ggtggaagtt agccacattc tttaattctc cctttttttc tgccttgatg gtaaaaaaaa
1560aaaaaagaaa caaacaaccc gaaaaacaca cacaaacagg aacacaaagc gccttttaag
1620ggtcctgaat ttggatacag aaaaagcagt cagttgcagg cccttctaga agtccccatg
1680tgggttggtt atgaatgggg aaattgcttg gtgttggagt tggacatcag actctacagt
1740tgcgactctg ccagcttgtt acctggcaac gcagctggag acagaatact tggcattccc
1800cttgatgaca aggaaagaat attttggggc taaaagagcc ccgtgtcttt gctgcctggt
1860aattcctgca cgcatctttt cctattttgc aacgccatag gcttccagcg actgctggtg
1920atgtttctgg taagttagag cttggggcag tgcggaccag ttctgtgaac ggctcagtgg
1980cagaattact tatctagcct tccttcactc ctaacccaga aacttcttaa ttcttgcccc
2040ttaagtgtgc agatctttct gccacgtcag ataaggccct agctgccctg ccagagctga
2100ttggggtggt tgtgtttagg cctagtaggt actgaggaaa agcctctttg gaatggctga
2160ggcctgctcc cacatcttct gtgtgaagtt gagggccctt gggctggttc cattcagggt
2220atgaggtgct ggaaactgct ctcagattac tggaagccag ggtctgtggc cttccctggg
2280gtttatactc tgtaaaccca tgttaaaaat accagcagat tgcaaatatt agtacactgt
2340aggttgtaag cttcttcagg gcatggggcc tattgctgga gagagatgcc acccgtgtac
2400atctggtgca ggctgctggt aagaactcac tggcccctgt gtggcaatgc ataccagatg
2460ggtgagaggg gaggaaacac attcagtgaa acagaaggtg agggcagggc agccctgacc
2520acagatggag ttgacttcaa cttgaccttt atttatgtct ttgacaaaag tagtatactc
2580ctactttgtg ccagacacca tgccgggtgc tggggataga gctgggaata aaaccagcag
2640agactctttc aaaaccctta ggagctcaaa ttctgatgtg ggagggggca gacagtaagc
2700aagatagatg ttgactagta tgatatatgg gtacaagagc taaggaaggc caggcactgt
2760ggcttacacc tgtaatccca gaattttggg gggctgaggt gggaggattg cttgaggctg
2820ggagctccag accagcctgg gcaatatagt gagaccccat ctctacaaaa ataaaaaata
2880aaattagcca ggcacgatgg tgcatgtctg tggtcttagc tactcaggag gatcatttga
2940gcccaggagg tcaaggctgc agtgaggtac aattgtgcca ctgcactcta gcctgggtga
3000caaagcaaga ccctgcctcc cccttctccc cccaaaaaga gaagagctaa ggagaaacag
3060gcaagaaagg tgtgtgcaca aaagtttgta tagggcagcc agaaaagtcc tcactgaagg
3120aatcgctgag gaggggagga agcaggccat tttcggtatt gggggaagag ggactcgcag
3180gtgccaaggg catgatggaa gagcagagag gatggtgcga aggctggctc agcaggcacc
3240aggtggagtg acaggatgag gttcggcagt ggggtctgta gagggctcac aggccatttt
3300tgagagcttt cgcttttact ttgcagggtt ttgagaggag tatcgttacc tgatttccat
3360cttatcggga gcattctagc ttcagggacc tggcaagaga ggatgatggc ttggacctgg
3420gtggtggcgc tggggatggt gaagaagtgg ttggattctg gatatatttt gaaggaggag
3480ccagtagtgg ggaaaggttc caattcaggc gattttacat aaaaatctag atacgcagca
3540ggcactcact tatggcaagg gtgggcttgt ctgagggtgg cttctggttt tggtggtttg
3600gatgtgagag aagggaagga atgaaggatg acaccaagga gtctactaga gtttgttcca
3660aaatggctgt tctggccgcg tgcggtggct cccaggactt tgggaggccg aagcaggcgg
3720atcagttggg gccaggagtt cgagacctgc ctggccacca tggtgaaacc cggtctctac
3780taaaaataca aaaattagct gggtgtggtg gcaggcgcct gtagtcccag ctactcaggg
3840gctgaggcag gagaattgcc tgaacccagg aggtggagct tgcagtgagc cgagatcacg
3900ccactgccct ccagtgtagg cgacagagtg agactctgtc tcaatacata catacataca
3960tacatacata catgcatgca tacatacata catacataca taaaatatac aaagttgctg
4020tcctgccttc ttgagccccc aggaattgga acctttcccc actctctgat cttttgctgg
4080gacatgctga ctgagcagcc tttctgctga gagcatgggt aggaatgtgg agggagcagt
4140tatgcctggg gctggctgcc tgcggctgga cctctagcct cctgctggga gcagcaagaa
4200gccagggatg tgttttgaaa tccttacttg gtattgggtg ctaggagccc cagacaggga
4260ggagagtcag cctaacgtgc ctctggtgac tggtgtaatt ccatcctgca ctctcgccaa
4320gaggacagtg tttgtgcaat gcatcagctg aagattcgtg gtggctgtca cttcggaggt
4380tttcagggag gcctagctgc tgctctgtgt atttcaggta gcttgtcacc acttatctct
4440cagagaaggg cagaccatgg ctgtatctcc accatacagg ctgaacagca gacaggggtc
4500tcaaactcca gtgccctggg ccacactgga gggcacttgg ctgtcatgga gtgaagggag
4560aggccgcctt cagcccagcc catccttgcc atgagtgagt gcctgctgca tttctagatt
4620tttatataaa atctcctgat tttttttgac tggtttaaat ttttattatt ttggtaaaaa
4680acgtataaaa cttaccatct tagtcattgt tcagtgtaca gtattgttaa gtacattcgc
4740actgttgtgc agacattacc accatccatc accagaactt tgtcaccttg caaaaccgaa
4800actctctacc catgaaacaa tacctcccca cttcccgtcc ccagtccctg gcagccacct
4860ttttactttc tgtttctatg aatttgacta ttctaggtac ctcatgtaag tagaagcata
4920tagtatttgt cttttgtgac tggtttattt cacttagtta gcataatgcc ccccaggttc
4980atccactttg tagcaggtgt cagaatttcc cttcttttca aggctgaatc atattccatt
5040gtatgtagat aacagtagtc ccccttatcc ttggaggatg catttcaaga tccccagtgg
5100atacctgaaa ctgcaaagcc tgtagatact atgttttttt cctatacata cagatctatg
5160ataaagttta atttatgaat taggaacagt aagagattag caataataac tagtaataaa
5220atagaacaat tataacaata tactgtaatg aaagttacat gaatgtgatc tcttaaaata
5280tcttactgta ctgtactcac ctattttcag actatggttg actgtgggta actgacacca
5340caggtaactg acgtcatgga aataaaacct ttgataaggg gggactgtat cacattgtct
5400ttatccattc atctgtgatg gacacgtggg ttgcttctat cttttgctgt tgtgaacatt
5460gctgctatga atgtgggcat acatatatct ctttcagacc ccgctttcga tatttttgga
5520tgtatataca gaagcagaat tgctggatca tatagtaatt cttgtccttt tcttttcttt
5580ttttttttcg agacggagtc ttgctctctt tcgcccatgc tggagtgcag tggcgcgatc
5640tcagctcact gcaagctccg cctcccgggt tcatgccatt ctcctgcctc agcctcccca
5700gtagctggga ctacaggcgc ctgccaccac gcctggctaa ttttttgtat ttttagtaga
5760gtcagggttt cactgtgtta gccaggatgg tctcgatctt ctgacctcgt gatccacccg
5820cctcagcctt ccacagtgct gggattacag gtgcgagcca ccgtgcccgg cagtaattct
5880tttcctttta gctaaggaac acccatactg ttttccacag cagctgcacc atttcacatt
5940cccaccaaca gggcacaaga gttccaattt ctccacatcc ttgctagcac tttattttct
6000gttttgtttt tcttttcctg atagtagctc tcttagtggt tgtgagggga tagtggggtg
6060atatctcatt atggttttga tttgcatttc cctgatgatt agtgatgttg agcatctttt
6120catgtgcttg ttggccattt gtatatcatc tttggacttg aaatgtctat ttaagtcttt
6180tgtccattat atttatttat ttattttgag atggagtctt cctgttaccc aggctggagt
6240gcagtggcat gatctctgct cactgcaacc tccacctcct gggttcaagc aattctcctg
6300cctcagcctc ccaaatagct gggactacag gtgtgtgtca ccacaccagg ctaatttttt
6360ttctattttt agtagacaca gagtttcacc attgtggcca ggctggtctc gaactcctga
6420cctcaagtga tctgccctct tcagccttcc aaagtgctgg gattacaggc atgagccacg
6480gtgcccagcc agtcttctgt ccattttaac gttgagttat ttgttttatt gttgagattt
6540actgattttt aaaacttggt caccaattaa gattttttta aaaaaccagt acctggaaca
6600agcagaacaa gtctctgctg gccttggctc atgttgctgt tctcagttcc cctgggatgt
6660ttgcttccag ggaggcctgg gcactcctga ctttggtgac agccctgctt gctctctctc
6720tgttacctgt aggtttcccc ttccacattc actgcctccg ggcaggcact gttgtgtttt
6780aggcatttca gtatcccagt ggggtactgg ataagtgctt agttagcacc tgccggtgag
6840taaataatca ggtcctgtgg tctctgaggg tttgacacat caggtctttg atcttgacct
6900tgaactctcc tagccatgcc tgcctgaagc ccaaccgtgg agcccaggct gaggctgaaa
6960cctgaagaac tggccccaag tgagtctctc cttagggctc ctgattatga tagttcattt
7020tttttttttt ttaacaaatt tgattagctg tcctcaaatt aactcatagg agatgctccc
7080cagaactaaa ctagctctgc aacagctcaa cagactttcc gcaggttctg cagctctttc
7140cactcaagct tcagaaaaaa gtgaaggaat attgtagatt gggttcaaaa tccccatcgc
7200gtcttgggaa aggcagtaga gccagcagcc agccaccttt tgttctctag ggaatggaat
7260agtccaaggc tgtgtttgtg ttctgcttct ctacatctga cccacgggtc ttccagaggc
7320tgcatttggg tcagggacct gggctctatc ttgcctctga tgcagaccac actctctgag
7380tctcattatt ccccctaaat gatctctaag attattttta gattaaaaaa aaaaaacaaa
7440ctctttgcat atctttggaa agtcagttgt ttgaggtctg ttaggcttta atcacttttg
7500ttttaaatgt gccgaggtgg tttctaggcc tgcttttcac aggtattctg tcccttgtca
7560gttcttccca cccagttttt tttgtttgtt tgtttgtttt tttgagatgg agtctcgttc
7620tgttgcccag gctggagtgc agtgccgtga tcttggctta ctgcaacctc cacctcccgg
7680gttcaagcga ttctcctgcc tcagcctcct cggtagctgg gattataggc acgtgccacc
7740atgcctaatt tttctatttt tagtagagat ggggtttcac catgttggcc aggctggtct
7800tgaactcctt accttgagtg atccacctgc ctcagcctcc caaagtgcta ggattacagg
7860catgagccat tacacccagc cccaacccag tgttttcaaa taatcattct cttcccttca
7920cctgatttgc tgtgtctaat ctagagtgga gctgaagaca catcaccacc tctctaagga
7980ctgtgtgtaa cacaagagta attgggctgt aagtgaggct gaggagtgct gctttgagga
8040aagggcacag ctctcagctg agctggtgag atttccctgt gactgaagtt ttattagatc
8100ttgttccctg ctctgcattt gctgcttctt cccaggctgt gggcagagga gcaggctggt
8160gccccggtgc ccctatctgc tgcaggctga ggttcaacaa gccttgtcca aggcagctgt
8220actgattcat tgttaggtgg ccagttcctg agttttcttt gaaattcact tcccagactg
8280ttgggtattc ctgcgagtca gactctcctt cagtagcgtc ccctgccccc taccctccac
8340tggtctccct ggacctctga tcagcccctc attgagtcct ttgatgcttc tctggtagga
8400ctgacccacc tgcgtcggct gggatcaagg gttctgagtt ccattcgcag gtgctgtaag
8460cctgtccttc ctgttgaata gggtcagagt cctcgtgact ctgctgtttt caagctctgt
8520aaccttgggc agtaagctgt taacctctct gagcctcagt ttcccacact taaaatggag
8580ataatggcca ggcgtggtgg ctcacgcctg taatcccagc actttgggag gccaaagtgg
8640gtggatcacc tgaggctagg agttcgagac cagcctggcc aacatggcaa aaccccgtct
8700ctactaaaaa tacaaaaatt agccgggcct ggtggcgtgt gcctgtaatc ccagctactc
8760aggaagctga gacagcagaa tcgcttgaac ccgggaggca gaggttgcag tgagccgaga
8820tcacgccatt gcattccagc ctgggtgaca gaccaaagac tctgtctcaa aaaataaata
8880aataaataaa taaattaatt aattaaataa aatggaggta atgatacctc cttggggttg
8940tttttgggat taaatggaat cacattgtac agcattggta cactgtaagg cacatagtag
9000gcactcaata cctatctata ctatttcctt tatcaccaca agttagttga gggctcttgg
9060gttgcacgca acagacaaag ttagtgactg gttaacttgg agaggatttt attatgagct
9120acacagcgta gctcatagaa ttgcagggaa aactataaag aactaagtct tggacaaaag
9180taatatcttg gcatgggcct gtagccccag ctactaagga ggctgaggtg caaggattgc
9240ttgagccccg gagtctgagc ctggcttggg caacagagag agataaagag accctgactc
9300taaacaataa gtaaatacat aaaagaggac ccaggccctc cttaggaact ggatggcagg
9360agcccctgga caacctctta ctgatttggt gctggatgag gcagccgcag ctagccagtg
9420ttctttgtgt tgatctcctc tgccttcata ttccaggggg agagggtctg acaggccaga
9480ctggccccca ccctcttggc cactggtggg ctgggcatgt ttttgggtag ttctacctag
9540ccagattaaa gtgggggtgg ggtggggagt ccagccagcc tgggcaacag ggcaagactc
9600catctctaca aaaaaatttt aaaattaggc tggcacggtg gctcacgcct gtaatcccag
9660cactttgcgg gggtcaaggc aggtggatca cttgaggtca ggagtttgag accagcctgg
9720ccaacatggt gaaaccctgt ctctactaaa aatacaaaaa attagccagg tgttgtggtg
9780cacacctgaa atccccgcta cttgggaggc tgaggcccga gaatcacttg aactcgggag
9840gcggaggttg cagtgggctg agatcatgcc actgcactcc caccctgggg gacaatagcg
9900aaacttcgtc tcagaaaaaa aaaaaattaa aaatagctgg gtgtggtggc atgcgcctgt
9960agtcccagct acttgggagg ctgaggtcag aggatcactt gaagccagga agtcaatgct
10020gcagtaagct atgatggcat cagtgcattc cagcctgacc aatggaacag gaccctgcca
10080agaaagagag agagaaaggg aggaaggaac gaaaggaagg aaggaaggaa agaaaggaaa
10140ggaaggaaag aaaggaaagg aagtaagtaa ggatggatgg atccaggtgc tctaaaccag
10200cagttcccaa agtttttggc accaggggcc agtttcatgg aagacaattt ttccacgggt
10260ggcagggtgg tgggcagcgg ggatggtttt gggatgagtc aagtgcatta catttattgt
10320gcactttatt tctattatta ttacattgta atatataatg aaaaaattat atagctcacc
10380ataatgtaca atcggggggt cctgagcttg ctttcctgca actagacagt cccatctgga
10440ggtgctggaa gacagtgaca gatcatcagg cattagattc tcataaggag tatgcaacct
10500agatccctcg tgtgcgcagt tcccaggcat gagctcaggt ggtagtagtg ctcactcacc
10560tgcagctctc ctcctgctgt gtggcccagt tcccaacagt ccgtggacct gcactaaagg
10620ctgtggcctg gtctgctgac ctctctccag agcccacggt actagtccat ggcctgggag
10680ttggggaccc ctgctctaag cagtgaggga gctgatttgc agacggggga gtggacaccg
10740ggcagctgga gccctggctt tctgccactg tctcctggtg aagggcgggc ctggctggga
10800ggagagggcc cccctccagc ctccccaggg gcatgatgcg ctgtgtgtcc ctgcttctag
10860atgccgacaa aaggatcaag gtggcgaagc ccgtggtgga gatggatggt gatgagatga
10920cccgtattat ctggcagttc atcaaggaga aggtagtgcc ccctcctgaa gtgggtggct
10980ctccaggtgg gctggccagg gattgttctg tcccacaggg tcttctggac tgcaggtccc
11040taggaccccc ccgttgtcct ggtaggcagc agcagctctg tttctctccc tctgtctacc
11100cttctttcac atctggtcca ctaattgttc agaagtcgtc aggcgggggc ctgtccccag
11160cagtccgtgt tgtgatggtg ccagatccca cacgttctgt caactttgag aagcttcaag
11220gttaatcctg tatcatttcc atcttgatcc cctacgtttt gcctcacttc ttgaaaagga
11280gtgaaaaggg aacagggctg gtgtgtaggg cagtgaccca gcctgcagtt gtgacgagcc
11340accatggcaa aggggtccca gagtggccgc ttggcttctc caaagttgcc gtggtctatg
11400tatgtccagg agagcatgta gtccttgtga aggccccaca ctgtgtgtgc gttcatggga
11460caaaggttga gaactgtcac ttccaactgt aagatctcaa agcacttgag aagaggaaac
11520cagttgtata gagaaatcta gatgtacttg gggttggggt ttggctgagt tgatgggcca
11580tgtgaggggg gcacacaggc acagtggagg aagaaccctc caaaagactg cggcctggcc
11640tgccaacctc tctccaaagc cccagcctct gccagctctg gccaggcccc actgagaaat
11700ggctgactcc agctttctgc tgcgcccctc cactggcctt cactcatccc tgttttgact
11760gactgtcccc tgccatggcc tgcagacttc ttatcctgcc ctttgttgtc atgtccctga
11820gtcactgggg tgacgccttg ctctggccct ctgtccccag ctcatcctgc cccacgtgga
11880catccagcta aagtattttg acctcgggct cccaaaccgt gaccagactg atgaccaggt
11940caccattgac tctgcactgg ccacccagaa gtacagtgtg gctgtcaagt gtgccaccat
12000cacccctgat gaggcccgtg tggaaggtgc gagggtgtgg aggtgggcgg gccagggagg
12060gtcacaggct tctcccaccg gcctctccag acttggggtg gggcagttgg ccatgtcact
12120catctcggga ctgggaggtt gggaggctcc agagctgggg ctttcctgag gccaactgca
12180cctgaggcca gtctccctgt gtgtgcctgg tggacagtgg ggcctcagag gtcacctttg
12240atgaggctgg ggcaggcgtg ggtaaggggc tggcctcagg ttccacggtt agggcacagc
12300agagctgaga acagaatcca tgtcttccat ctcccaggcc agtggtgttt ctgcttcact
12360ctggctctga cagtggtagg tgtcatcggt gacagggctg aggaggagga ggaggaggaa
12420ggtaatgctg atgtggtcac agtaaggatg gcttctttgg gcagtagtcc attctggcgt
12480ggacagtctt gcaggcaggt atgcagagag attgtgcaga ggagtgctgt gtgtaaggcc
12540tgtgtccttc agagcctcag cagcctctgg ggaacattgc tgttgccctc ctgccactgg
12600cttggccttg caggtctgcc tctgtcccca tggtcatgca gggtcactga gaggtgcccc
12660caccaggcct agactggctt ctggtccttg gctgttgggg ccgctctcga gggttccatg
12720aagtcacagc agtgtgtgtg cagaggggcc aggtttggat aattcgagaa aggatggttg
12780aggagttttc tgagctctct cttcctactt tccacagttg gagggagctg gcggaaagta
12840ctcgagatac atctgcaaat tccccaggcc tgcccctgtc ctgcaggtca tgcctgaccc
12900acagcactgg gatcatttga gtgttgagct cttcatttca cctgaacctt gggagttgtg
12960tatccccatt tatggacaag gcaggagagg gtcacagcct taggaactgg ggtggcgttg
13020gggccaggac cggagcatgt ggagtgggca gtgtgttgtc aggcttcgtc agacaagtcc
13080ttcccccgga ctgtactccc tccatgtgtg atgtgggaat cataatggcc aacagagcac
13140ttagcatgga ccgggcaccg ttctaggccc tttacacacg agctcatttc gtcctcacga
13200caacacttag gctggttatt tttccagtaa ttttttttta cagctttggt tgagccactt
13260ttgtaagcct caccattaaa actggcagac ttgctgggca tggtggctca cacctgtaat
13320cccagcactt tgggaagccg aggcgggtgg atcacctgag gttgggaggt cgagaccagc
13380ctgaccaaca tggagaaacc ccatctctcc taaaaataca aaattagctt ggtgtggtgt
13440cacatgcctg taattccagc tgctcgggag gctgaggcag gagaaccgct tgaacccagg
13500aggcagaggt tgtggtgagc cgagatcgcg ccattgcact ccagcctggg caataggagc
13560aaaactctgt ctcaaaaaaa aaaaaaaaaa aaaaaaaatt ggcagactcc agagcccaca
13620catttgcact ctagactcta ctgccttcct catgaagaat tttaggaccc ccgtctggct
13680gtgttgttgc ttggggttca aattctggtt gaaagatggc ggctgcagtg ggaccactat
13740tatctctgtc ctcacagagt tcaagctgaa gaagatgtgg aaaagtccca atggaactat
13800ccggaacatc ctggggggga ctgtcttccg ggagcccatc atctgcaaaa acatcccacg
13860cctagtccct ggctggacca agcccatcac cattggcagg cacgcccatg gcgaccaggt
13920aggccagggt ggagagggga tccactgacc tgggcacccc ccgactggag ctcctcgcct
13980agccatcctc ttgtctctgc agtacaaggc cacagacttt gtggcagacc gggccggcac
14040tttcaaaatg gtcttcaccc caaaagatgg cagtggtgtc aaggagtggg aagtgtacaa
14100cttccccgca ggcggcgtgg gcatgggcat gtacaacacc gacgaggtga ggctggcttg
14160ggcatcctgg gcccctcctc tcccagcttg tctcttcatc tctgtctcgt ggctttcctt
14220tcttctgtaa tggcctcatt cttaggccac aaagaggcag aaatggccac cagggctggg
14280catggtggct gacacttgta atcccggcat tttgggaggc caaggcagga ttgcttgaga
14340ccagaagttt gagaccagcc tgggcaacag tgagacccca tctcttgaaa caaaaagaaa
14400agaaaagaaa agaaaagaaa tggccacgag cagctccagg cgtactcctg cctgcttggc
14460taccctatca gaagagaatg cctctttatc cccagttcca gctccaatgc caggctgagt
14520cacatgacca cctctgagcc aatcacagag gccctgggga gaaaggcttc tgattggata
14580agccagggac acactgtcaa ccccagcgct aggcctggga attagccctg ccccagccac
14640atgtagtcta aggcggtgct ttccaaaaaa aagttgtttc caaaaaaaaa aaaaaaaagg
14700cggtgttttc caaaaaaaaa aaaaaggcgg tgttttacaa agcaaagttg agagggagag
14760gctgggccag cagaaacatc gtgtgcactg cacggaggct ggtgttaaac agtcgcgtgg
14820gcggcggggt accgttcctg gagagctggg ccttgccctg ggaggtggga ggttgccggc
14880aatcgccagg ctagggcacc acgccagggc cctgtctctc cccctgcagt ccatctcagg
14940ttttgcgcac agctgcttcc agtatgccat ccagaagaaa tggccgctgt acatgagcac
15000caagaacacc atactgaaag cctacgatgg gcgtttcaag gacatcttcc aggagatctt
15060tgacaagtaa agcctcatcc atgtactctg tggcctttct tcccttcccc ccatgctgtt
15120cccatcctac cctgggaagg tcgctattag agtgcatttg gctcagctcc gaggctcagg
15180gagggatccc caacctgtca gccttctgcc ctctccccat aacagacctt tttactccca
15240ggcactataa gaccgacttc gacaagaata agatctggta tgagcaccgg ctcattgatg
15300acatggtggc tcaggtcctc aagtcttcgg gtggctttgt gtgggcctgc aagaactatg
15360acggagatgt gcagtcagac atcctggccc agggtacgct gggaggacgc tgctccctgt
15420gggggtggac tgttggtctt ctctggctgg agggattttc agaccctttt ggtagaaaac
15480tctagtggag caggactcat tgcagggtcc tctgtggaca gcagggggca ggagctccct
15540ggcatctgag tgagagagga tcacaaatta ggtttggact ggtgtatgac tgaggctgct
15600cttagagaga aaggagggca caggaattcc agggctaggt tgacagccct aaggttgctc
15660cagtccatga tggagcctca tgactctttg gttccagtag gaaaatggga tcaagcggga
15720ctggaggttc tttaaactac agcgaatgca ttttgcatag tgaacctaat ggatggaaga
15780gaatgttggg gaagcctgca aacccccaag ccctagggtg tcctaaaaga caaatcagat
15840tgcagtaaaa agtataggtg atgaggtcag gagtttgaga ccagcgtggc caacatgacg
15900aaaccccgtc tctactaaaa atgcaaaaaa atttagctgg gcatggaggc gggcacagtc
15960atggacacct gtaatcccag ctacttgaga ggctgaggca ggagaatctc ttgaacccag
16020gaggtggagg ttgcagtgag ccgagattgc gccattgcac tccagcctgg gcaacaaggg
16080tgaaactccg tctccaaaaa aaataaaaaa taaaaaataa agtataggtg agaccattag
16140agaagaacag cgagaaatgg gccaattgtg ttgggaacaa gagcaggaaa ggtggtaggt
16200gtgggaaaca ggcaggacat agagagtgaa agagaaacct aagcttacca gggcagctcc
16260tggtatgggg aaaagggaag cccaggacgg gttctgatga aaagcagagt cttgttactt
16320tgtgtaaacc tttggcttta ctttggaaag ttcagtgggg atcctctcac cgaacaattc
16380ccatctagga tagaaggatg aaacgccata gcagatgagg cagaggcatg aaaatgaacc
16440ttaagtgtct aaggaatggt gtgaaggtgc aggtaaaatg gagaagggat tgcttacagc
16500caaaattctt agaattcata gacaaagcat tttcctgtag atgttgtcca tgttttcttt
16560cttcaatcct tattttggtg tcatgggggt gcctttgaag ccctggagtc cttgacaata
16620gaaaagcttg ctggagttga catgtggatt tgggagcatt cagaaattaa tcaaaaagct
16680tgaaagtggc ctaagagagt agctgcaaaa gtgattgttg ggaaatagct gaccacagct
16740ttattgtttt ccttgaatgt gcctccgggt cacgagccag gctgggtggc aggctgtggg
16800ggaccacagg actctgtggc ctcttgggcc ctgtgggcca caggctgtgg ggcgcctgga
16860gctggtgaca cagatggatg ttaatgtgct ggtgatagcc accctccagt gccctccagc
16920cctgtgctgg gccctggaga cccacaggag ggtgaagaga cctggaacag tccctgtcct
16980cccagttgca gctgggggag gctgagtaga gccacgaact atggcagcta caatattggg
17040ttgtagaggg cagcagggct cagctgggtg gccccaggag aggcgaggcc ctgagagaaa
17100ggctttctac cctccaggct ttggctccct tggcctgatg acgtccgtcc tggtctgccc
17160tgatgggaag acgattgagg ctgaggccgc tcatgggacc gtcacccgcc actatcggga
17220gcaccagaag gtgagtgcag ggcatggggc ctcacaatgc ccctctaccc caggggccta
17280aagcccactg ggctgagggc tggaaggacg agcctgaccc accagcccag gggcgggcag
17340ctgtatctgg gcagcctcct cactagctgg ctcggctctt gatctccctg caacccccgt
17400ccccagggcc ggcccaccag caccaacccc atcgccagca tctttgcctg gacacgtggc
17460ctggagcacc gggggaagct ggatgggaac caagacctca tcaggtgagc atggagggag
17520aggccggagc tgcccaggac aggctctggg tcctgccctt gcacagatgg ggtctcattc
17580tgccccatcc ccataggttt gcccagatgc tggagaaggt gtgcgtggag acggtggaga
17640gtggagccat gaccaaggac ctggcgggct gcattcacgg cctcagcaag tgcgtggcct
17700ggggtggtag gcagaccctg gggccatgtg ggaggaagcc aggggacccc tcctaaagtc
17760cccctcatga gtcagcttag ctgcaagggg gcctggggca ggacatgtcc acagccctga
17820gagactgctc aggccagcct ctgtagacca ggtctagtga gttcctcccc atccctgagg
17880ctggctactc agagctcctt ccgaccctgc ccacacccct ttcccagctt ctctcaggag
17940agcagttacc tggcaagaca gaccctgcgg gtgcctgccg aatctcggtg gcctcatggt
18000agggggctat agctggcctc tggcctgtag tctgggtggc aggagatggc tgttctgatg
18060cccaagctca ggctgttccc tggaagggcc tggctgatgg ccttggcaag gcctggagcc
18120acccctgatg tgagtggtgc tctctctgca gtgtgaagct gaacgagcac ttcctgaaca
18180ccacggactt cctcgacacc atcaagagca acctggacag agccctgggc aggcagtagg
18240gggaggcgcc acccatggct gcagtggagg ggccagggct gagccggcgg gtcctcctga
18300gcgcggcaga gggtgagcct cacagcccct ctctggaggc ctttctaggg gatgtttttt
18360tataagccag atgtttttaa aagcatatgt gtgtttcccc tcatggtgac gtgaggcagg
18420agcagtgcgt tttacctcag ccagtcagta tgttttgcat actgtaattt atattgccct
18480tggaacacat ggtgccatat ttagctacta aaaagctctt cacaaaattg tctgctgtgt
18540ttgtccctga ggggaggagg tagtgggacc ctgaggcaga ggccctgcta gagctggcag
18600gttcccctgg ggcagaccag agcacctcag gaaggggctg ccacggcagg gaagggacca
18660ggcagccctg ggagcccgca ttccacaggg gcccactgcg gagttctcgg acactcaggg
18720cacaggcctg tgggttccct ggaattttct agcatgatcc agtttctgtg tccagttctc
18780cattctgaga gtcaatcagt tcctgatagg ttgtcattga tttttttctt cgttggtttt
18840aaccttctaa acatctccag gccactttct tagccttttt ctaggtacta aaaagaggtc
18900ctacccacac ctgcctcaca cttctccttt ccaaggctgc ctgagtttgg aggggcttgg
18960gtgtgtgtga acaagggccc tgcattgtct aggcctgcag ttcccaggct tgggttcact
19020ttcaccatgc attggcaaaa ctagaaaagt aagcttgtga caaattgttc tcggccgggc
19080acagtggcgc acgcctataa tccctgtact ttgggaggct gaggtgggtg gatcacttga
19140ggccaggagt tcgagaccag cctggccaac atggtgaaac cccatctcta ctcaaaatac
19200aaaaattagc caggcgtggt gatgcgcacc tgcagtccca gctactcggg aggctgaggc
19260aggaaaatgg cttgaacctg ggaggcagag gttgcagtga gccgagactg caccactgca
19320ctccagcctg ggtgacagag caagactctg tctcaaaaaa aaaaaaaaaa aaaaaaaaaa
19380aaaaattgct ctatgcaagt tttttagccc catgtaaaaa ggaaaaataa aagttgctct
19440aaagctacat ataatcaaaa
19460
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