BROWN UNIVERSITY Patent applications |
Patent application number | Title | Published |
20160139149 | CHI3L1 FOR THE DETECTION AND TREATMENT OF NONALCOHOLIC STEATOHEPATITIS - Disclosed herein are compositions and methods for detecting nonalcoholic steatohepatitis (NASH) measuring CHI3L1 levels. In some embodiments, the methods described herein can distinguish NASH from nonalcoholic fatty liver disease. CHI3L1 levels can also be used to monitor treatment progress in patients having NASH. Also disclosed herein are compositions and methods for treating NASH by targeting CHI3L1. | 05-19-2016 |
20160130257 | Macrocyclic proteasome inhibitors - Compositions are provided for selectively inhibiting bacterial proteasome. Also provided are methods for assaying the compositions, methods for treating bacterial infection, and methods for inducing apoptosis in tumor cells using the compositions. | 05-12-2016 |
20160124443 | POWER MAPPING AND MODELING SYSTEM FOR INTEGRATED CIRCUITS - This invention relates in general to a system, apparatus, and method comprises one or more mapping and modeling systems used for power estimation, management, and improved efficiencies for the integrated circuit. In addition, the invention provides a feedback telemetry and actuation system, apparatus, and method for controlling the flow speed and temperature of coolant fluid over an integrated circuit | 05-05-2016 |
20160104026 | METHODS AND APPARATUS FOR IDENTIFYING SUBJECT MATTER IN VIEW DATA - In one aspect, a method and apparatus for detecting subject matter of interest in view data obtained by scanning an object including generating a filter adapted to respond to the subject matter of interest, splatting the filter onto a portion of the view data to provide a filter splat, and performing at least one operation on the portion of the view data using the filter splat to facilitate determining whether the subject matter of interest is present in the portion of the view data. | 04-14-2016 |
20160073887 | OPTOELECTRONIC DEVICE TO WRITE-IN AND READ-OUT ACTIVITY IN BRAIN CIRCUITS - Systems, apparatus and methods for a neural implant are provided. In one embodiment, a neural implant that can both optically stimulate neurons and record electrical signals from neurons is provided, including a wide band gap semiconductor opto electronic microarray, such optoelectronic microarray including a plurality of needles, each providing both optical transparency and electrical conductivity; a flexible optical conduit from the optoelectronic microarray to an optical signal source; a flexible electrical conduit from the optoelectronic microarray to an electrical signal sensor; integration of the optical and electrical conduits to a single monolithic optical cable; a circuit assembly coupled to the electrical signal source and the optical signal source; and a processor for providing control of at least one of the electrical signal sensor and the optical signal source. Further embodiments are described herein. | 03-17-2016 |
20160046684 | Methods and compositions for treatment of PTP1B-related diseases - Cancer, obesity, and diabetes are examples of PTP1B-related diseases. The invention herein provides embodiments of therapeutic methods and compositions for treating PTP1B related diseases by engineering peptides that bind to the functional spine of PTP1B to alter the conformation of the protein and inhibit a function of PTP1B. Molecules bind to amino acid residues of the functional spine of PTP1B, regulate the catalytic cycle, and treat PTP1B-related diseases. For example, molecules bind to at least one of Tyr152, Tyr153, His175, Thr178, Pro185, Phe191, Leu192, Asn193, Cys215, Gly218, Phe280, Val287, Trp291, Lys292, Leu294, Ser295, and Glu297 to reduce at least one symptom of a PTP1B related disease. | 02-18-2016 |
20160046674 | ENOPEPTINS, USES THEREOF, AND METHODS OF SNYTHESIS THEREOF - Provided herein are inventive enopeptin compounds of Formula (I): | 02-18-2016 |
20160038571 | Method and compositions for treatment of calcineurin-related diseases - Therapeutic compositions for treatment of protein serine/threonine phosphatase-related diseases are obtained by engineering amino acid sequences that disrupt interaction between the protein serine/threonine phosphatase and a protein inhibitor and are provided herein. Calcineurin and PPI are examples of protein serine/threonine phosphatases. RCAN1 is an inhibitor of calcineurin and is overexpressed in patients with serious diseases, such as Down syndrome and Alzheimer's disease. Molecules that bind RCAN1 at regions that interact with calcineurin selectively modulate functions of calcineurin to treat these diseases. Methods of treating a subject for a protein serine/threonine phosphatase-related disease by administering a molecule having an amino acid sequence selected from the group of SEQ ID NOs: 1-19 are further provided. | 02-11-2016 |
20150370325 | Context-Aware Self-Calibration - A method for context-aware self-calibration includes measuring for a plurality of time segments, at least one feature of at least one biosignal or each of at least one channel. Each biosignal is created in response to a user imagining an intended direction for each time segment. An object is moved along an actual decoded direction determined by an output of a decoder configured to correlate for each time segment the at least one feature to the intended direction. The decoder self-calibrates to minimize for each time segment, an error between the actual decoded direction, and the intended direction inferred subsequent to the respective time segment. | 12-24-2015 |
20150324646 | NAVIGATION METHODS AND APPARATUS FOR THE VISUALLY IMPAIRED - According to some aspects, a wearable device for estimating a location of the device within a space is provided, the device comprising a plurality of cameras mounted to a structure, at least a portion of the structure being adapted to facilitate a user wearing the device, the plurality of cameras having substantially fixed positions and orientations on the structure relative to each other, and at least one processor configured to receive image data from the plurality of cameras, perform feature detection on the image data to obtain a first plurality of features from the image data, and determine an estimate of the location of the device in the space based, at least in part, on a location associated with a second plurality of features obtained from image data previously captured of the space that matches the first plurality of features. | 11-12-2015 |
20150258213 | Nanotubes as Carriers of Nucleic Acids into Cells - The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids. | 09-17-2015 |
20150216935 | Autologous Cell-Based Therapy for Treating Obesity - Compositions and methods for producing autologous brown adipose cells in vitro or in vivo are provided. In particular, a drug delivery device is described that recruits adipose stem cells (ASCs) to a site in the body of a subject. These ASCs may then be isolated and induced to differentiate into autologous brown adipose cells. Alternatively, the drug delivery device may also include differentiation factors that induce differentiation of the recruited ASCs into brown adipose cells in vivo. The brown adipose cells produced by these methods may be used therapeutically to treat conditions, such as obesity and diabetes. | 08-06-2015 |
20150196773 | OPTOGENETIC CONTROL OF ENDOTHELIAL CELLS - The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to transport therapeutics across the vascular barrier into tissues such as the brain and the lung, with high spatial and temporal precision, and for controlling vascular properties such as vascular tone, arterial diameter, and vascular growth. | 07-16-2015 |
20150139525 | METHODS AND APPARATUS FOR MODEL-BASED DETECTION OF STRUCTURE IN VIEW DATA - In one aspect, a method for determining a value for at least one parameter of a configuration of a model, the model associated with structure of which view data has been obtained from at least one x-ray scanning device capable of producing x-ray radiation, the view data being obtained, at least in part, by scanning at least a portion of the structure, wherein the view data is attenuation data of the x-ray radiation attenuated by the structure as a function of view angle about the structure is provided. The method comprises acts of operating on the view data to detect at least one feature in the view data, and determining the value for the at least one parameter of the configuration of the model based, at least in part, on the at least one feature. | 05-21-2015 |
20150121575 | DEVICE AND METHOD FOR MEASURING DISTRIBUTION OF ATOMIC RESOLUTION DEFORMATION - The present invention relates to an atomic resolution deformation distribution measurement device that can measure a deformation rate of an atomic scale with low expense by improving resolution using an AFM system, and the atomic resolution deformation distribution measurement device includes: a laser source generating a laser beam; a first cantilever and a second cantilever provided close to a measurement specimen or a reference specimen to cause deformation by an atomic force; an optical system controlling a light path of the laser beam so as to cause the laser beam to be sequentially reflected to the first cantilever and the second cantilever and locate the first cantilever and the second cantilever to an image point; a measurement unit measuring the laser beam reflected from the second cantilever; and a stage on which a measurement specimen or a reference specimen is located and movable in X, Y, and Z axis directions. | 04-30-2015 |
20140278134 | Conserved Nucleotide Elements In Ribosomal RNA - The present invention relates to a method of determining conserved ribosomal RNA (rRNA) nucleotide motifs that are specific to one domain of life, Eukarya, Bacteria, or Archaea, and degenerate in at least one other domain of life. The invention also relates to a method of determining conserved ribosomal RNA (rRNA) nucleotide motifs that are specific to one subgroup and degenerate in another subgroup within a domain of life or for a subset group within a domain of life. The invention relates to a method of identifying a compound that is a domain-specific or subgroup-specific ribosomal RNA inhibitor. | 09-18-2014 |
20140270435 | SPACIAL SEQUENCING/GENE EXPRESSION CAMERA - Methods, articles and systems that provide imagewise mapping or display of gene expression of a biosample, by contacting the biosample, such as a tissue slice or metacommunity, to a detector which captures material from the biosample and processes the captured material. In one embodiment the detector has an array of one or more capture sites at defined positions on the detector, each site carrying an immobilized capture oligonucleotide and a site-indexing oligonucleotide. The array captures mRNA from the biosample contacted thereto, and the captured mRNA is processed to form a sequenceable amount of amplified captured material which includes the site-indexing oligonucleotide, so that when sequenced, detection of the site-indexing oligonucleotide indicates the original capture location on the array, thereby mapping the sequenced material to its capture location and imaging display of gene expression distribution in the original biosample. In some embodiments the site-encoding sequence is integrated with the capture oligonucleotide. In other embodiments, the detector is a modified sequencing flow cell, which is opened to allow the biospecimen to be contacted to a capture surface; processing is performed while the material remains on the capture surface and locations of the resulting sequences correspond to the location of origin of the templates of the biomolecules in the sample. The spatially resolved sequencing, gene expression camera and technology in various embodiments are applied to genome sequences and DNA fragments present in the biosample, for example to study or diagnose developmental, disease, and tumor conditions. | 09-18-2014 |
20140245006 | CRYPTOGRAPHIC ACCUMULATORS FOR AUTHENTICATED HASH TABLES - In one exemplary embodiment, an apparatus includes a memory storing data and a processor performing operations. The apparatus generates or maintains an accumulation tree for the stored data—an ordered tree structure with a root node, leaf nodes and internal nodes. Each leaf node corresponds to a portion of the data. A depth of the tree remains constant. A bound on a degree of each internal node is a function of a number of leaf nodes of a subtree rooted at the internal node. Each node of the tree has an accumulation value. Accumulation values of the root and internal nodes are determined by hierarchically employing an accumulator over the accumulation values of the nodes lying one level below the node in question. The accumulation value of the root node is a digest for the tree. | 08-28-2014 |
20140203558 | KINETIC ENERGY HARVESTING USING CYBER-PHYSICAL SYSTEMS - The present invention provides a system for engaging a fluid flow. The system comprising one or more foil members operationally connected to a feedback control loop system. In one embodiment, the foil member is a hydrofoil member or an airfoil member. The foil members are configured for one or more degrees of freedom of oscillatory movement within the fluid flow. The feedback control loop system comprises a sensor system, actuator system, and a controller system. The feedback control loop system configured for actuating the foil members and thereby optimizing the operation of the foil members to attain one or more optimization objectives. In operation, the foil members are situated in the fluid flow and are manipulated to attain one or more optimization objectives. | 07-24-2014 |
20140182668 | HIGH EFFICIENCY SILICON-COMPATIBLE PHOTODETECTORS BASED ON GE QUANTUM DOTS AND GE/SI HETERO-NANOWIRES - The present disclosure focuses on Ge nanostructured materials for optoelectronic devices: including high-efficiency quantum dot (QD) photodetectors and Si and Ge heteronanowire solar cells. The common thread among these materials is the use of Ge/Si or Ge/oxide barriers to confine carriers and enhance photoconductive gain in detectors and optical absorption and spectral coverage in solar cells. | 07-03-2014 |
20140178348 | Methods using DNA methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies - Methods using DNA Methylation arrays are provided for identifying a cell or mixture of cells and for quantification of alterations in distribution of cells in blood or in tissues, and for diagnosing, prognosing and treating disease conditions, particularly cancer. The methods use fresh and archival samples. | 06-26-2014 |
20140172377 | METHOD TO RECONSTRUCT A SURFACE FROM ORIENTED 3-D POINTS - A method for the problem of reconstructing a watertight surface defined by an implicit equation from a finite set of oriented points. As in other surface reconstruction approaches disctretizations of this continuous formulation reduce to the solution of sparse least-squares problems. Rather than forcing the implicit function to approximate the indicator function of the volume bounded by the surface, in the present formulation the implicit function is a smooth approximation of the signed distance function to the surface. Then solution thus introduced is a very simple hybrid FE/FD discretization, which together with an octree partitioning of space, and the Dual Marching Cubes algorithm produces accurate and adaptive meshes. | 06-19-2014 |
20140171482 | Nanotubes as Carriers of Nucleic Acids into Cells - The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids. | 06-19-2014 |
20140132357 | Broadband Distributed Transmission Line N-Path Filter - In an embodiment, a single-ended transmission line N-path filter includes one or more filter stages, each stage having a first series inductive element, a shunt N-path filter, and a second series inductive element; an input port; and an output port. | 05-15-2014 |
20140111241 | OPTICAL TESTING OF A MULTI QUANTUM WELL SEMICONDUCTOR DEVICE - A pump light pulse is generating a strain pulse in a sample that includes quantum wells. A signal is measured using a probe light pulse. The probe light pulse is delayed in relation to the pump light pulse. The signal derives from a change in an optical property of the sample, which optical property responds to the generated strain pulse. One may deduce parameters of interest of the sample, including the quantum wells, from the characteristics of the signal. For discerning between various components of the stress in the quantum wells a lead pump pulse, preceding the pump light, pulse my also be used. A system for the application of such methods is also disclosed. | 04-24-2014 |
20140105242 | Device and methods for temperature and humidity measurements using a nanocomposite film sensor - Devices and methods are provided for a nanocomposite having a phase change polymer matrix and conductive nanoparticles to provide greatly enhanced responsivity to temperature and/or humidity. A sensing film includes carbon nanotubes (CNTs) and the polymer. Operation near the transition temperature increases the TCR by over an order of magnitude, thus providing a new platform for devices such as IR sensors, bolometers and imaging elements, MEMS devices, compensating or uncompensated circuit elements and other electronic devices. Nanocomposite films may be under about one micron thick, and coatings, constant environment chambers or mounts, and other engineered improvements and variations may be provided to further enhance the response, range, response times or sensitivity of the film-based devices. One embodiment employs a nanocomposite film under one micron in thickness to operate as an uncooled but highly sensitive infrared bolometer under ambient conditions. | 04-17-2014 |
20140094674 | IMPLANTABLE WIRELESS NEURAL DEVICE - Systems and methods for providing an electrical interface to a body are provided. In one embodiment, an implantable module is disclosed, comprising: an implantable electrode array, implantable within a body and capable of providing a plurality of communication channels for communicating electrical signals detected in a body; an amplifier circuit for processing electrical signals received from the electrode array; a wireless transceiver for sending and receiving telemetry data between the amplifier circuit and a wireless receiver located outside of the body; and a sealed enclosure that houses the amplifier circuit and the wireless transmitter and is biocompatible with surrounding tissue, the enclosure having a window that is transparent to a wireless medium used by the wireless transceiver. In another embodiment, a wireless transceiver and amplifier is detachably coupled to a transcutaneous attachment device, and the implantable electrode array is electrically coupled to the interface board via the transcutaneous attachment device. | 04-03-2014 |
20140094403 | ENOPEPTINS, USES THEREOF, AND METHODS OF SYNTHESIS THERETO - Provided herein are inventive enopeptin compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Further provided are methods of preparation, use, and treatment. | 04-03-2014 |
20140081432 | Method and Apparatus for Rehabilitation Using Adapted Video Games - A participant, engages in healthcare provider prescribed physical rehabilitation exercises utilizing specifically designed controllers, and these exercises are mapped to one or more video game commands. These commands are coupled with other inputs to control the video game that will be used to ensure adherence to a prescribed rehabilitation regimen. Information is gathered on the participant, in order to aid in rehabilitation. | 03-20-2014 |
20140078260 | METHOD FOR GENERATING AN ARRAY OF 3-D POINTS - A method that estimates the coordinates of the calibration points in the projector image plane using local homographies obtained from the imaging camera. First, a dense set of correspondences between projector and camera pixels is found by projecting onto the calibration object an identical pattern sequence as the one later projected when scanning the target, reusing most of the software components written for the scanning application. Second, the set of correspondences is used to compute a group of local homographies that allow projection back of any of the points in the calibration object onto the projector image plane with sub-pixel precision. In the end, the data projector is then calibrated as a normal camera. | 03-20-2014 |
20140043017 | ELECTROMAGNETIC POSITION AND ORIENTATION SENSING SYSTEM - Magnetic tracking systems and methods for determining the position and orientation of a remote object. A magnetic tracking system includes a stationary transmitter for establishing a reference coordinate system, and at least one receiver. The remote object is attached to, mounted on, or otherwise coupled to the receiver. The transmitter can include a set of three mutually perpendicular coils having a common center point, or a set of three coplanar coils with separate centers. The receiver can include a set of three orthogonal coils. The position and orientation of the receiver and the remote object coupled thereto is determined by measuring the nine mutual inductances between the three transmitter coils and the three receiver coils. The magnetic tracking system provides reduced power consumption, increased efficiency, digital compensation for component variation, automatic self-calibration, automatic synchronization with no connections between transmitter and receiver, and rapid low-cost implementation. | 02-13-2014 |
20140038906 | THERAPEUTIC AND DIAGNOSTIC METHODS INVOLVING BIGLYCAN AND UTROPHIN - The present disclosure provides methods for predicting a patient's response to biglycan therapy for diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, for example, due to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Examples of such diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders. This application also provides combination therapeutics, such as a biglycan therapeutic and a utrophin therapeutic. | 02-06-2014 |
20130331383 | NITROFURAN COMPOUNDS FOR THE TREATMENT OF CANCER AND ANGIOGENESIS - The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds. | 12-12-2013 |
20130307919 | MULTIPLE CAMERA VIDEO CONFERENCING METHODS AND APPARATUS - In some aspects, a multi-camera device to facilitate multiple camera video conferencing is provided. The multi-camera device comprises a plurality of input ports, each configured to receive video information when connected to a respective external video camera, an output port configured to output video information, and a selection component coupled to the plurality of input ports and the output port, the selection component configured to provide video information received by at least one of the input ports to the output port for output to an external computer. | 11-21-2013 |
20130280319 | Compositions, methods and kits for therapeutic treatment with wet spun microstructures - Methods, compositions, systems, devices and kits are provided for preparing and using a multi-layer polymeric microstructure composition for delivering a therapeutic agent to a subject. In various embodiments, the therapeutic agent includes at least one selected from the group of: a drug, a protein, a sugar, a carbohydrate, and a nucleotide sequence. In related embodiments, the composition is a fiber, a suture, a sphere, an implant, or a scaffold. | 10-24-2013 |
20130270995 | LIGHTING APPARATUS FOR CAPTURING AND STABILIZING MERCURY - The present invention is a method and material for using a sorbent material to capture and stabilize mercury. The method for using sorbent material to capture and stabilize mercury contains the following steps. First, the sorbent material is provided. The sorbent material, in one embodiment, is nano-particles. In a preferred embodiment, the nano-particles are unstabilized nano-Se. Next, the sorbent material is exposed to mercury in an environment. As a result, the sorbent material captures and stabilizes mercury from the environment. In the preferred embodiment, the environment is an indoor space in which a fluorescent has broken. | 10-17-2013 |
20130244123 | BIOCATHODE-PHOTOANODE DEVICE AND METHOD OF MANUFACTURE AND USE - A system for harvesting electric energy from illumination by photons by photo- and bioelectrocatalysis includes an electrode coated with conducting polymer matrix containing the oxidoreductase, laccase, and a redox mediator, 2,2′-azino-bis(3-ethylbenzothiaxoline-6-sulfonic acid (ABTS). The photo-anode is based on nanocrystalline TlO2 (Degussa, P25) adhered to a fluorine tin oxide (FTO) electrode. The device operation is based on a continuous photocatalytic oxidation of water to oxygen at a TiO2-photoanode and bioelectrocatalytic reduction of oxygen to water at a biocathode under illumination with light. | 09-19-2013 |
20130236815 | Multimetallic nanoparticle catalysts with enhanced electrooxidation - A new structure-control strategy to optimize nanoparticle catalysis is provided. The presence of Au in FePtAu facilitates FePt structure transformation from chemically disordered face centered cubic (fcc) structure to chemically ordered face centered tetragonal (fct) structure, and further promotes formic acid oxidation reaction (FAOR). The fct-FePtAu nanoparticles show high CO poisoning resistance, achieve mass activity as high as about 2810 mA/mg Pt, and retain greater than 90% activity after a 13 hour stability test. | 09-12-2013 |
20130236523 | Antipathogenic Surfaces Having Selenium Nanoclusters - The present invention is directed to methods for inhibiting growth of pathogens and to substrates with selenium nanoparticles or selenium nanoclusters having antipathogenic properties. | 09-12-2013 |
20130233700 | SYSTEM AND METHODS FOR DETERMINING MOLECULES USING MASS SPECTROMETRY AND RELATED TECHNIQUES - The present invention generally relates to mass spectrometry and related techniques, and in some cases, to determining single species using mass spectrometry. In certain instances, polymers such as DNA or RNA can also be sequenced. Certain embodiments of the invention relate to passing a polymer, such as DNA, RNA, a protein, a polypeptide, a polysaccharide, etc., through a pore and cleaving the polymer in sequence. For instance, the polymer may be cleaved using a laser or an electric field. In some embodiments, a property of at least one subunit of a polymer is determined using mass spectrometry. In some embodiments, a single ion (which may be a subunit of a polymer, or an ion based on another species) can be isolated in a mass spectrometer and a signal generated from the single ion. | 09-12-2013 |
20130231276 | Combination Of An Aminoacyl-tRNA Synthetase Inhibitor With A Further Antibacterial Agent For Attenuating Multiple Drug Resistance - Bacterial multidrug resistance is attenuated in a subject by administering an aminoacyl-tRNA synthetase inhibitor and an antibacterial agent to the subject, wherein the aminoacyl-tRNA synthetase inhibitor is distinct from the antibacterial agent. | 09-05-2013 |
20130209683 | Methods of Making Nanowires - The present invention is directed towards methods for growing diamond nanowires via chemical vapor deposition and apparatuses that incorporate these diamond nanowires. | 08-15-2013 |
20130199539 | Nanostructured Surfaces - The present invention is directed to methods for inhibiting growth of bacteria and to nanometer scale surfaces having antibacterial properties. | 08-08-2013 |
20130190402 | Methods Of Treating Autism With mGluR5 Antagonists - mGluR5 antagonists are used for the treatment of autism. The human treated by the methods of the invention can also have fragile X syndrome, epilepsy and anxiety. | 07-25-2013 |
20130189366 | DRUG DELIVERY SYSTEMS AND METHODS OF USE - Disclosed herein are systems for delivery of one or more molecules (such as a drug, for example, a small molecule, polypeptide, and/or nucleic acid) to a subject, for example to a targeted location in the subject. In some embodiments, the delivery system includes an encapsulated inducing agent or repressing agent and a plurality of cells. In some examples, the inducing agent or repressing agent and the cells are each separately encapsulated. In other examples, the encapsulated inducing agent or repressing agent and the cells are co-encapsulated. The cells include one or more genes which are operably linked to an inducible promoter or a repressible promoter which is inducible or repressible by the encapsulated inducing agent or repressing agent, respectively. Methods of use of the delivery systems, for example to treat or inhibit a disease or disorder in a subject, are also disclosed. | 07-25-2013 |
20130177536 | Enhancement Of Skeletal Muscle Stem Cell Engraftment By Dual Delivery Of VEGF And IGF-1 - An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors such as VEGF and IGF; and (c) a population of myogenic cells. Implantation of the device leads to muscle regeneration and repair over an extended period of time. | 07-11-2013 |
20130146542 | Functionalized chromatographic materials and methods of making and using therefor - Methods, compositions, devices and kits having a novel chromatographic material are provided herein for separating and identifying organic molecules and compounds, for example molecules and compounds containing electron rich functional groups such as carbon-carbon double bonds. The methods, compositions, and kits include a metal-thiolate chromatographic medium (MTCM) with a sulfur-containing functional group or a metal-selenolate chromatographic medium (MSCM) comprising a selenium-containing functional group covalently attached to a support medium, such that the sulfur-containing functional group or selenium-containing functional group is bound to at least one metal atom. The MTCM and/or MSCM has affinity and specificity to compounds having one or more carbon-carbon double bonds, and performs a highly efficient and rapid separation of samples yielding non-overlapping peaks of purified materials compared to traditional media. | 06-13-2013 |
20130137155 | METHODS AND DEVICES FOR ENCAPSULATING CELLS - Molds for making cell aggregation devices include upper and lower surfaces. Methods of aggregating cells include depositing cells on in a seeding chamber, incubating the cells and removing aggregated cells. Devices for encapsulating aggregates of cells include biocompatible, bio-sustainable substrates compartments and a coating of a biocompatible, bio-sustainable polymer that completely surrounds the substrate and cell-encapsulating compartments. | 05-30-2013 |
20130129788 | Nanotubes and Compositions Thereof - The present invention is directed to implants and the modification of the surface of implants using amino acid or polypeptide functionalized rosette nanotubes. | 05-23-2013 |
20130109625 | MECHANOTRANSDUCTION BY THE SYNERGISTIC ACTION OF HETEROTYPIC CELL INTERACTIONS | 05-02-2013 |
20130095499 | Methods, compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging - Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues. In various embodiments, the nanoparticle composition includes at least one of: a nanoparticle, a polymer layer, and a binding agent, such that the polymer layer coats the nanoparticle and is for example a polyethylene glycol, a polyelectrolyte, an anionic polymer, or a cationic polymer, and such that the binding agent that specifically binds the cells or the tissue. Methods, compositions, systems, devices and kits are provided for identifying potential therapeutic agents in a model using the nanoparticle composition and spatial frequency heterodyne imaging. | 04-18-2013 |
20130079288 | DIFFERENTIAL EFFECTS OF DRUGS ON TRANSPORT IN A MULTI-LAYER 3D SPHEROID MODEL - Drugs are screened for affects on inhibiting efflux pumps and blocking gap junction communication in tumors by culturing cells to thereby form self-assembled spheroids and incubating the spheroids. Uptake of a substrate of the efflux pump and distribution of a substrate for the efflux pump within the spheroids is imaged to thereby select drugs that inhibit the efflux pump or do not block gap junction communication. Selected drugs can then be employed to treat a tumor. | 03-28-2013 |
20130071940 | METHODS OF CHEMOSELECTIVE DERIVATION OF MULTIPLE CLASSES OF METABOLITES - Chemoselective derivatization of biological amines, carboxylic acids, aldehydes or ketones are employed in methods to detect a plurality of components, or members of a component, such as metabolites, that vary in molecular structure. The methods of the invention can be employed in aqueous and nonaqueous conditions. | 03-21-2013 |
20130019520 | Methods of Making Fatty Acids and Fatty Acid Alkyl Esters - The present invention is directed to methods of making fatty acid esters from glycerides and free fatty acids. | 01-24-2013 |
20120264961 | FE3O4-M(AU-LIKE)-NANOPARTICLES FOR ANTIBODY-CONSERVING TARGET-SPECIFIC PLATIN DELIVERY - An antibody-conserving method for linking a therapeutic platinum compound to nanoparticles comprising Au Like-Fe | 10-18-2012 |
20120252029 | SIMULTANEOUS QUANTITATIVE MULTIPLE PRIMER DETECTION OF CLOSTRIDIUM DIFFICILE - This invention comprises a multiplex-capable oligonucleotide which is capable of hybridizing to at least one of the | 10-04-2012 |
20120179031 | METHODS AND SYSTEMS FOR PROLONGED LOCALIZATION OF DRUG DELIVERY - An effective method for prolonging localization of therapeutics within the rat gastrointestinal tract of at least about 12 hours is provided. The method includes localization of therapeutic agents that are nanoparticulated or nanoencapsulated. Attractive forces between an orally administered magnetic dose and an external magnet were monitored and internal dose motion in real time using biplanar videofluoroscopy was visualized. Tissue elasticity was quantified as a measure of tissue health by combining data streams. The methods address safety, efficacy, and monitoring capacity of magnetically localized doses and show a platform for testing the benefits of localized drug delivery. | 07-12-2012 |
20120171121 | Rosette Nanotubes as Drug Delivery Agents - The present invention is directed to delivery complexes of rosette nanotubes and one or more biologically active agents or diagnostic agents. | 07-05-2012 |
20120114214 | METHODS AND APPARATUS FOR IDENTIFYING SUBJECT MATTER IN VIEW DATA - In one aspect, a method and apparatus for detecting subject matter of interest in view data obtained by scanning an object including generating a filter adapted to respond to the subject matter of interest, splatting the filter onto a portion of the view data to provide a filter splat, and performing at least one operation on the portion of the view data using the filter splat to facilitate determining whether the subject matter of interest is present in the portion of the view data. | 05-10-2012 |
20120108655 | Methods of Diagnosing and Treating Carcinomas - Methods of diagnosing a carcinoma include comparing the expression of miRNAs in a sample with a control and determining ratios of expression of miRNAs. Methods of treatment include administering a nucleic acid encoding a miR-375 gene product. Methods of optimizing treatment in a subject include determining expression of an miR21-gene product. | 05-03-2012 |
20110204219 | SYSTEM AND METHODS FOR DETERMINING MOLECULES USING MASS SPECTROMETRY AND RELATED TECHNIQUES - The present invention generally relates to mass spectrometry and related techniques, and in some cases, to determining single species using mass spectrometry. In certain instances, polymers such as DNA or RNA can also be sequenced. Certain embodiments of the invention relate to passing a polymer, such as DNA, RNA, a protein, a polypeptide, a polysaccharide, etc., through a pore and cleaving the polymer in sequence. For instance, the polymer may be cleaved using a laser or an electric field. In some embodiments, a property of at least one subunit of a polymer is determined using mass spectrometry. In some embodiments, a single ion (which may be a subunit of a polymer, or an ion based on another species) can be isolated in a mass spectrometer and a signal generated from the single ion. | 08-25-2011 |
20110125263 | METHOD FOR PRODUCING NANOSTRUCTURES ON A SURFACE OF A MEDICAL IMPLANT - A method for treating a surface of a medical implant to create nanostructures on the surface that results in increased in-vivo chondrocyte adhesion to the surface. Further, disclosed is a method to fabricate a drug delivery system. The drug delivery system includes a medical implant that has undergone a surface treatment process that results in the modification of the surface configuration and topography. The modified surface acts as a depot or reservoir for loaded biological material, biologic agents or pharmaceutical products. Additionally, a device for delivering pharmaceutical products or other biological materials is disclosed. The device includes integrally attached nanostructures that retain or adsorb the loaded pharmaceutical products and/or biological materials. Further disclosed is a medical implant that includes a surface configured to allow for and regulate protein adsorption. The surface of the medical implant has a layer of nanostructures rigidly attached with varying porosity and orientation that allow for surface protein adsorption to be controlled. | 05-26-2011 |
20110059904 | SERUM-BASED, DIAGNOSTIC, BIOLOGICAL ASSAY TO PREDICT PREGNANCY DISORDERS - The invention provides serum-based, diagnostic, biological assays for predicting disorders of pregnancy resulting from poor trophoblast and/or placental ischemia, including preeclampsia. Serum samples from such subjects exhibit an ability to disrupt the architecture involving fetal trophoblasts and maternal endothelial cells in a three-dimensional, dual cell co-culture system provided herein, in contrast to normal pregnancy serum samples. Based on these distinctions, the assays are employed to predict pregnancy outcomes as early as first trimester. | 03-10-2011 |
20110053766 | NANOSTRUCTURED SORBENT MATERIALS FOR CAPTURING ENVIRONMENTAL MERCURY VAPOR - The present invention is a method and material for using a sorbent material to capture and stabilize mercury. The method for using sorbent material to capture and stabilize mercury contains the following steps. First, the sorbent material is provided. The sorbent material, in one embodiment, is nano-particles. In a preferred embodiment, the nano-particles are unstabilized nano-Se. Next, the sorbent material is exposed to mercury in an environment. As a result, the sorbent material captures and stabilizes mercury from the environment. In the preferred embodiment, the environment is an indoor space in which a fluorescent has broken. | 03-03-2011 |
20110052463 | NANOSTRUCTURED SORBENT MATERIALS FOR CAPTURING ENVIRONMENTAL MERCURY VAPOR - The present invention is a method and material for using a sorbent material to capture and stabilize mercury. The method for using sorbent material to capture and stabilize mercury contains the following steps. First, the sorbent material is provided. The sorbent material, in one embodiment, is nano-particles. In a preferred embodiment, the nano-particles are unstabilized nano-Se. Next, the sorbent material is exposed to mercury in an environment. As a result, the sorbent material captures and stabilizes mercury from the environment. In the preferred embodiment, the environment is an indoor space in which a fluorescent has broken. | 03-03-2011 |
20110049045 | NANOSTRUCTURED SORBENT MATERIALS FOR CAPTURING ENVIRONMENTAL MERCURY VAPOR - The present invention is a method and material for using a sorbent material to capture and stabilize mercury. The method for using sorbent material to capture and stabilize mercury contains the following steps. First, the sorbent material is provided. The sorbent material, in one embodiment, is nano-particles. In a preferred embodiment, the nano-particles are unstabilized nano-Se. Next, the sorbent material is exposed to mercury in an environment. As a result, the sorbent material captures and stabilizes mercury from the environment. In the preferred embodiment, the environment is an indoor space in which a fluorescent has broken. | 03-03-2011 |
20110048982 | NANOSTRUCTURED SORBENT MATERIALS FOR CAPTURING ENVIRONMENTAL MERCURY VAPOR - The present invention is a method and material for using a sorbent material to capture and stabilize mercury. The method for using sorbent material to capture and stabilize mercury contains the following steps. First, the sorbent material is provided. The sorbent material, in one embodiment, is nano-particles. In a preferred embodiment, the nano-particles are unstabilized nano-Se. Next, the sorbent material is exposed to mercury in an environment. As a result, the sorbent material captures and stabilizes mercury from the environment. In the preferred embodiment, the environment is an indoor space in which a fluorescent has broken. | 03-03-2011 |
20110028333 | DIAGNOSING, PROGNOSING, AND EARLY DETECTION OF CANCERS BY DNA METHYLATION PROFILING - A method of employing DNA methylation analysis for the diagnosis, prognosis, and prediction of cancer. | 02-03-2011 |
20100323262 | REACTANT DELIVERY TO A REACTIVE SURFACE IN A CHANNEL - The present invention provides geometric arrangements for channels through which liquids or other fluids can be made to flow, for enhanced performance of fuel cells or other chemical or biochemical reactors or analyzers. Systems and methods including these improved geometries are described herein for enhanced performance of a variety of devices. Specifically, in one set of embodiments, the reactors comprise one or more microchannels comprising a tapered cross-sectional area and at least one reactive surface portion. By flowing a liquid comprising one or more reactants through the channel such that the cross-sectional area decreases in a downstream direction, relatively more reactant may be supplied to the wall at downstream positions relative to the amount that would be supplied in a system without a tapered cross-section. In some embodiments, the microchannel may be constructed and arranged such that the amount of reactant supplied to the wall conforms to a predetermined distribution. | 12-23-2010 |
20100228745 | SYSTEM, METHOD, AND APPARATUS FOR SORTING AT LEAST PARTIALLY DYNAMIC DATA - Embodiments of methods, apparatuses, devices and systems associated with sorting candidate values are disclosed. | 09-09-2010 |
20100110935 | Efficient Content Authentication In Peer-To-Peer Networks - A method and distributed network are provided. The method includes: providing an abstract tree structure having a root node, a plurality of tree nodes, and a plurality of leaf nodes, wherein each leaf node corresponds to at least a portion of data (box | 05-06-2010 |
20100050276 | Transgenic non-human animal models of apoptosis-mediated conditions - A transgenic non-human animal whose genome comprises a stable integration of a transgene that encodes at least one Fas-ligand protein operably-linked to a tetracycline-inducible promoter includes cells that express the transgene and undergo apoptosis. The transgenic non-human animal can be used to screen for compounds that inhibit apoptosis and to identify cells that are capable of differentiating in vivo. | 02-25-2010 |
20090191099 | HIGH-THROUGPUT SOLVENT EVAPORATOR AND GAS MANIFOLD WITH UNIFORM FLOW RATES AND INDEPENDENT FLOW CONTROLS - The evaporator ( | 07-30-2009 |
20090123053 | METHODS AND APPARATUS FOR MODEL-BASED DETECTION OF STRUCTURE IN VIEW DATA - In one aspect, a method and apparatus for determining a value for at least one parameter of a configuration of a model associated with structure of which view data has been obtained including detecting at least one feature in the view data, and determining the value for the at least one parameter of the configuration of the model based at least in part on the at least one feature. In another aspect, a method and apparatus for detecting at least one blood vessel from object view data obtained from a scan of the at least one blood vessel including generating a model of the at least one blood vessel, the model having a plurality of parameters describing a model configuration, determining a hypothesis for the model configuration based, at least in part, on at least one feature detected in the object view data, and updating the model configuration according to a comparison with the object view data to arrive at a final model configuration, so that the final model configuration represents the at least one blood vessel. | 05-14-2009 |
20090092875 | FUEL CELL, MEMBRANE ELECTRODE ASSEMBLY - An acid resistant composite catalyst comprising dumbbell-shaped composite nanoparticles each comprising a noble metal nanoparticle epitaxially conjugated to a ferrite particle, and/or flower-shaped composite nanoparticles each comprising a noble metal nanoparticle epitaxially conjugated to at least two ferrite particles. The acid resistant composite catalyst is useful to facilitate the reduction of oxygen. The acid resistant composite catalyst can be used in a fuel cell comprising a fuel electrode, an oxygen electrode, and a polymer electrolyte membrane placed between the fuel electrode and the oxygen electrode. The oxygen electrode includes the acid resistant composite catalyst. | 04-09-2009 |
20090022777 | Methods for progenitor cell recruitment and isolation - The invention relates to the use of one or more growth factors in a drug delivery system, optionally with an external mesh housing, to recruit and optionally harvest progenitor cells. These cells include those that normally reside in the bone marrow. | 01-22-2009 |