IMPERIAL INNOVATIONS LIMITED Patent applications |
Patent application number | Title | Published |
20160114032 | BACTERIOPHAGE-POLYMER HYBRID - The invention provides a targeted bacteriophage-polymer complex comprising a recombinant targeted-bacteriophage and a cationic polymer. The complex has a net positive charge. The invention provides methods of preparing bacteriophages and complexes thereof, and to their uses for the delivery of transgenes in a variety of gene therapy applications. | 04-28-2016 |
20160108181 | METHOD AND CATALYST SYSTEM FOR PREPARING POLYMERS AND BLOCK COPOLYMERS - The present invention provides methods for producing block copolymers, either by the sequential addition of monomers, or using a “one-pot” method. The invention also relates to novel methods for producing polyesters by ring opening lactides and/or lactones and by copolymerising anhydrides and epoxides. | 04-21-2016 |
20160073913 | IMAGE DISPLAY INTERFACES - Apparatus for monitoring activation in a heart comprises a probe ( | 03-17-2016 |
20150361183 | INHIBITION OF THE COMPLEMENT SYSTEM - Agents and compounds which can be used to modulate the activity of the complement system, novel biological targets associated with such modulation, and pharmaceutical compositions, medicaments and methods of treatment for use in preventing, ameliorating or treating diseases that are characterised by inappropriate complement activity. These diseases include age-related macular degeneration (AMD), meningitis, renal disease, autoimmune disease and inflammation. Therapeutic antibodies and screening assays for identifying agents useful in treating these diseases are also provided. | 12-17-2015 |
20150284711 | USE OF A REWIRED GENETIC CONTROL NETWORK TO INCREASE PRODUCT EXPRESSION - A method of identifying a cell with increased production of a desired product, the method comprising: (a) providing a population of cells which produce the desired product; (b) introducing a plurality of distinct nucleic acid molecule species into the population of cells, wherein the nucleic acid molecules comprise a first region which is operably-linked to a second region, wherein the first region comprises a promoter region from a first gene, and the second region comprises a nucleic acid sequence from a second gene that is capable of expressing a regulatory product under control of the promoter region; (c) culturing the population of cells under conditions in which the cells express the regulatory product under control of the promoter region; and (d) testing the population of cells for production of the desired product, thereby to identify a cell or cells with increased production of the desired product. The method may further comprise isolating a cell or cells with increased production of the desired product. The method may further comprise repeating steps (b), (c) and (d) on the isolated cells or cells, or descendants thereof with increased production of the desired product, thereby to identify a cell or cells with further increased production of the desired product. Typically the desired product is not encoded by the introduced nucleic acid molecule. The plurality of distinct nucleic acid molecule species typically comprise a plurality of combinations of multiple first and multiple second regions. The expressed regulatory product typically is a polypeptide but may be an RNA molecule. The method may further comprise isolating the nucleic acid molecule(s) introduced into the cell or cells with increased production of the desired product. | 10-08-2015 |
20150276831 | FREQUENCY ESTIMATION - Determining a property of an electrical signal at a node instant at the current instant (INSTC); determining a previous function indicative of a property of the signal at the node at a previous instant; determining an error function in a previous frequency estimation at the node at a previous instant; determining a first current function indicative of the property of the signal at the node at INSTC in accordance with the determined property, the previous function, and the error function; receiving, from another node, a second current function indicative of a property of an electrical signal at the at least one other node at INSTC; combining the first current function and the second current function to produce a current combined function (CCF) indicative of a property of the signal at the node at INSTC; and estimating a current frequency of the signal at the node in accordance with the CCF. | 10-01-2015 |
20150274596 | CERAMIC MATERIAL - The present invention relates to method for forming a porous ceramic material, the method comprising the steps of: providing a suspension of polymer-coated ceramic particles in a first solvent; contacting the suspension with a second solvent, whereby a ceramic material precursor is formed from the polymer and ceramic particles, heating the ceramic material precursor to at least partially decompose the polymer within the precursor into solid deposits, and then sintering the ceramic material precursor to form a porous ceramic material. | 10-01-2015 |
20150214589 | RECHARGEABLE BATTERY - The present invention provides a rechargeable high temperature battery comprising a chamber defined by at least one wall formed at least in part as a solid membrane capable of passing oxide anions, and electrodes which are present on the inside and outside of the membrane that sandwich the membrane between them. The electrode on the outside of the chamber is an oxygen redox electrode, and the membrane exhibits good conductivity for the transport of oxide anions when it is at a temperature in the range of between about 500° C. and about 1000° C. The present invention also relates to a method of operating such a high temperature battery | 07-30-2015 |
20150190501 | METHODS AND COMPOSITIONS FOR RAISING AN IMMUNE RESPONSE TO HIV - A method of raising an immune response in an individual against human immunodeficiency virus (HIV) the method comprising: (a) administering to the individual DNA or SFV encoding an HIV Env protein and optionally nucleic acid encoding one, any two or all three of the HIV Gag, Pol and Nef proteins; (b) subsequently administering to the individual viral vector encoding an HIV Env protein and optionally viral vector encoding one, any two or all three of the HIV Gag, Pol and Nef proteins; and (c) administering to the individual oligomeric HIV Env protein; and an adjuvant. | 07-09-2015 |
20150184068 | ELECTROLUMINESCENT COMPOSITIONS - The present invention relates to compositions capable of emitting circularly polarized electroluminescence comprising an electroluminescent polymer and a chiral dopant, processes for the synthesis of such compositions and light emitting devices incorporating such compositions. | 07-02-2015 |
20150174576 | Microfluidic Device for Droplet Generation - The invention relates to a microfluidic system for generating droplets, the controlled merging of two or more droplets, and the analysis of droplets. | 06-25-2015 |
20150126708 | RADIOFLUORINATION METHOD - The present invention provides a method of radio fluorination of biological targeting molecules (BTMs) with the radioisotope | 05-07-2015 |
20150126359 | PROCESS FOR PRODUCING NANOPARTICLES - This invention relates to a process for the preparation of surface-functionalised metal oxide, metal sulphide, metal selenide or metal telluride nanoparticles, a process for the preparation of a composite material comprising such nanoparticles, nanoparticles and a composite material produced thereby, the use of such nanoparticles in catalysis and a catalyst comprising such nanoparticles. | 05-07-2015 |
20150115905 | Power Compensator - A power compensator for compensating voltage at a location along a power transmission line, the compensator having a controller for controlling a voltage generated across the compensator, wherein the voltage is controlled to maintain a power transmission line voltage at a value dependent on the power transmission line location. | 04-30-2015 |
20150084482 | POWER GENERATION DEVICE - A device able to generate electrical power through relative rotational motion of first ( | 03-26-2015 |
20150051370 | NOVEL BIMETALLIC CATALYTIC COMPLEXES FOR THE POLYMERISATION OF CARBON DIOXIDE AND AN EPOXIDE - The present invention provides a novel catalyst of formula (I): wherein M is selected from Zn(H), Co(II), Mn(II), Mg(II), Fe(II), Cr(III)-X or Fe(III)-X, and the use thereof in polymerising carbon dioxide and an epoxide. | 02-19-2015 |
20150011467 | OXYNTOMODULIN ANALOGUES AND THEIR EFFECTS ON FEEDING BEHAVIOUR - Compounds of the invention are novel peptide analogues of oxyntomodulin (oxm) in which one or more amino acids of the oxm sequence have been changed. Changing amino acids 15-24 of oxm to either amino acids 968-977 of the α-latrotoxin peptide (and variations thereof) or amino acids 15-24 of exendin-4 (and variations thereof), or combinations of sequences from these sources, and/or changing amino acids 27-33 of oxm to amino acids 27-33 of exendin-4, and/or the addition of amino acids to the C-terminus of the peptide, results in a series of analogues of oxm that demonstrate the oxm like activity of reducing food intake, and with certain embodiments a greater ability to decrease food intake. | 01-08-2015 |
20140352388 | METHOD OF FORMING PARTS FROM SHEET STEEL - A method is provided of forming a part from sheet steel. The method comprises the steps of (a) heating the sheet to a temperature at which austenitisation occurs; and (b) forming the sheet between dies into the part, father cooling the formed sheet. There is an additional step between (a) and (b) of applying cooling means to the sheet. | 12-04-2014 |
20140301947 | METHODS TO PREDICT BINDING AFFINITY OF TSPO IMAGING AGENTS TO TSPO - A method for aiding in selecting or adjusting a dose of TSPO imaging or therapeutic agent for use with a subject, the method comprising the step of determining the subject's genotype for TSPO rs6971. A TSPO imaging or therapeutic agent for use in TSPO imaging or therapy in a subject, wherein the subject is a subject whose genotype at TSPO polymorphism position rs6971 is determined. The subject's genotype for TSPO may be taken into account when assessing the results of the TSPO imaging, for example normalising the subject's determined measure of binding of the TSPO agent to take account of the subject's determined genotype. The subject's genotype for TSPO may be taken into account when choosing the TSPO agent and/or the dose of TSPO agent. The subject may be a subject who has been determined to have genotype CC or CT at TSPO polymorphism position rs6971, for example when using a TSPO agent that binds with higher affinity to Aia147TSPO than to Thr147TSPO. | 10-09-2014 |
20140298940 | METHOD OF MANUFACTURING MULTI-MATERIAL GEARS - A method of manufacturing a multi-material gear is disclosed. The method comprises the steps of (a) heating a first pre-form element of a first material to a temperature at which the first material can be formed; (b) heating a second pre-form element of a second material to a temperature at which the second material can be formed; and (c) forming the first and second pre-form elements in a die at least towards the shape of the gear, thereby providing bonding between the elements. | 10-09-2014 |
20140296480 | PEPTIDE SECRETED BY LACTOBACILLUS PLANTARUM WITH IMMUNOMODULATING FUNCTION - Among the fewer than 10 proteins primarily secreted by the species | 10-02-2014 |
20140260633 | Ultrasonic Non-Destructive Testing - An apparatus and method for ultrasonic non-destructive testing provides an elongate strip of ultrasound transmissive material coupled at a proximal end to an object under test. The elongate strip has a transverse cross-section with a width and thickness giving an aspect ratio greater than unity and matched to the ultrasonic transducer such that excitation induces a substantially non-dispersive ultrasonic signal to propagate along the elongate strip to the proximal end and to enter the object under test. These non-dispersive pulses are particularly suited for time-of-flight measurements, thickness measurements, crack measurements and the like. The elongate strip helps to separate the transducer from a potentially hostile environment associated with the object under test. The elongate strip also has a large area of contact with the object under test allowing efficient transmission of energy into the object under test. | 09-18-2014 |
20140249279 | METHOD OF SYNTHESISING POLYCARBONATES IN THE PRESENCE OF A BIMETALLIC CATALYST AND A CHAIN TRANSFER AGENT - The invention provides a process for the synthesis of a polycarbonate, the process comprising the step of reacting carbon dioxide with at least one epoxide in the presence of a catalyst of formula (I) and a chain transfer agent. The invention also provides a polymerisation system for the copolymerisation of carbon dioxide and at least one epoxide comprising a catalyst of formula (I) and a chain transfer agent, polycarbonates produced by the inventive process, a block copolymer comprising a polycarbonate produced by the inventive process and a method of producing the same. The invention also relates to novel catalysts of formula (III). | 09-04-2014 |
20140221280 | NOVEL COMPOUNDS AND THEIR EFFECTS ON FEEDING BEHAVIOUR - Peptide containing sequence from both the GLP-1 peptide and glucagon peptide, compositions comprising said peptides and methods of using said peptides for the treatment and prevention of metabolic disorders, for example disorders of energy metabolism such as obesity or diabetes, are provided | 08-07-2014 |
20140206064 | BACTERIAL METHODS - A bacterial spore comprising a modified prkC protein, wherein the extracellular domain of the modified prkC protein binds an agent which is not bound by the extracellular domain of the wild-type prkC protein, and wherein the agent is a germinant that stimulates germination of the bacterial spore, or a bacterial spore comprising a modified gerA protein, wherein the gerA protein has been modified such that the spore undergoes germination in the presence of a germinant which does not stimulate germination of a bacterial spore comprising wild-type gerA protein. | 07-24-2014 |
20140175587 | DEVICES AND METHODS FOR ABSORBING LIGHT - A light-absorbing device and method employ a series of photon-absorbing semiconductor substructures. A first semiconductor substructure provides first and second energy states. A difference between the first and second states being such as to cause an electron to be promoted from the first state to the second state upon absorption of a photon of a first energy. A second semiconductor substructure provides third and fourth energy states. The third state is arranged to receive the electron from the second state. A difference between the third and fourth states being such as to cause the electron to be promoted from the third state to the fourth state upon absorption of a subsequent photon of a second energy. The third state has a lower energy than the second state, such as to cause the electron to dissipate energy as it passes from the second state to the third state. | 06-26-2014 |
20140171964 | MEDICAL MASTER/SLAVE TYPE DEVICE FOR MINIMALLY INVASIVE SURGERY - Apparatus for Minimal Invasive Surgery (MIS) comprising a master device, a slave device, a detector for detecting a parameter of or associated with the slave device, and a shape locking system for locking the shape of the master device in response to a parameter detected by the detector. | 06-19-2014 |
20140156143 | VARIABLE-GEOMETRY SUSPENSION APPARATUS AND VEHICLE COMPRISING SUCH APPARATUS - A variable-geometry suspension apparatus for a vehicle is disclosed. The apparatus having a resiliently compressible member, such as a coil-over damper, an actuator and support structure, such as a chassis of a vehicle. The resiliently compressible member is mounted to the support structure for compression under the weight of a mass suspendable by the apparatus. The compressible member is mounted with at least one end of the compressible member displaceable in a displacement direction having a component perpendicular to the direction of compression, so that such displacement varies the geometry of the suspension apparatus and thereby varies the compression of the compressible member. The actuator is arranged for displacing the end of the compressible member in the displacement direction to vary the geometry and thereby vary the compression. Applications include motor vehicles such as cars and motorcycles. | 06-05-2014 |
20140154604 | Fuel Cell Comprising at Least Two Stacked Printed Circuit Boards with a Plurality of Interconnected Fuel Cell Units - A fuel cell comprising at least two stacked fuel cell boards ( | 06-05-2014 |
20140154069 | TURBINE WHEEL, A TURBINE AND USE THEREOF - A turbine wheel for low-pressure ratio applications is disclosed. The ratio of the outlet area of the wheel (A | 06-05-2014 |
20140142377 | DEVICE - A surgical device ( | 05-22-2014 |
20140129479 | METHOD TO AID IN THE EXPLORATION, MINE DESIGN, EVALUATION AND/OR EXTRACTION OF METALLIFEROUS MINERAL AND/OR DIAMOND DEPOSITS - A method to aid in the exploration, mine design, evaluation and/or extraction of metalliferous mineral and/or diamond deposits in a subsurface, the method comprising: providing three-dimensional seismic data acquired in a seismic survey of the subsurface; providing an initial model of the subsurface; performing wavefield tomography at least partly as a function of at least one property of the subsurface in three-dimensions using the initial model and the seismic data to generate an updated model; and determining an estimate of the at least one property of the subsurface from the updated model. | 05-08-2014 |
20140128330 | METHOD OF DIAGNOSIS AND PROGNOSIS - A method of measuring Gadd45β expression comprising the step of measuring Gadd45β expression levels in a sample of cells, for example CD 138 expressing cells, obtained from a subject known to have or suspected of having a haematological malignancy. Expression levels may be used in diagnosis, for example of multiple myeloma, in providing a prognosis, for example in a patient having multiple myeloma or in guiding selection of an appropriate treatment agent, especially a treatment agent comprising Gadd45β and or MKK7 inhibitors. Also datasets comprising measured expression levels from multiple subjects. | 05-08-2014 |
20140110311 | METHOD AND APPARATUS FOR FROTH FLOTATION CONTROL - A method of controlling operation of a froth flotation cell comprises introducing gas into a liquid in the cell, thereby to create a froth on the surface of the liquid, which froth overflows and leaves the cell at an overflow point, wherein the froth has a froth height from the level of the overflow point to the upper surface of the froth, measuring values of the froth height for two values of gas flow rate into the cell, measuring values the velocity at which the froth overflows at the overflow point for two values of gas flow rate into the cell, calculating a gas flow rate into the cell that optimises gas recovery, by treating the measured values of froth height and measured values of froth velocity independently, and setting the gas flow rate into the cell to be the calculated flow rate into the cell that optimises gas recovery. | 04-24-2014 |
20140090450 | Test Rig And Method For Simulating And Analyzing Petrochemical Fouling - An experimental test rig for simulating and analyzing the fouling behavior of petrochemicals when heated within a pipe or other such conduit, the rig comprising: a supply of petrochemical product; an annulus test section arranged to receive petrochemical product from the said supply, the annulus test section comprising an inner tube and an outer tube with the petrochemical product passing therebetween; a tubular test section arranged to receive petrochemical product from the said supply; a pipe circuit connecting the supply of petrochemical product to the test sections; means for heating a region of the annulus test section; means for heating a region of the tubular test section; and means for controlling and measuring the flow of the petrochemical product from the supply to the test sections; wherein the pipe circuit is configured such that the petrochemical product can be simultaneously supplied to the annulus and tubular test sections while they are heated. | 04-03-2014 |
20140057138 | Fuel Cell Comprising at Least Two Stacked Printed Circuit Boards with a Plurality of Interconnected Fuel Cell Units - A fuel cell comprising at least two stacked fuel cell boards ( | 02-27-2014 |
20140056960 | Methods for Improving Fracture Healing and Bone Formation - The invention provides a method of promoting bone formation in a patient at a site in need thereof, the method comprising the step of locally administering a pro-inflammatory compound to the site, wherein the pro-inflammatory compound is selected from one or more of TNF-α at optimal osteogenic dose of 0.5 to 50 ng/kg of patient body weight, or 0.01 to 3.5 μg, or 1 ng/ml or similar; IL-1β at optimal osteogenic dose of 0.1 ng/ml or similar; alarmins eg HMGB1, HMGN1, S100A8, S100A9, S100A8/9, S100A12, heat shock proteins, lactoferrin, cathelicidins, a-defensins, matrix components including versican, biglycan, fragments of hyaluronic acid and heparan sulphate; and TLR-2 or TLR-4 ligands. The invention also provides the above pro-inflammatory compounds for use in promoting bone formation in a patient at a site in need thereof. Kits comprising the compounds of the invention and a surgical implant are also provided. | 02-27-2014 |
20140048354 | LUBRICATION SYSTEM AND METHOD FOR REDUCING DIP LUBRICATION POWER LOSS - Energy loss in a dip lubrication system is reduced by reducing the immersion depth of the gear within a pool of oil. This can be accomplished by increasing the pressure within the dip lubrication system which effectively reduces the flow rate of the oil so that the oil remains separated from the oil pool for a longer period of time thereby reducing the oil level and the immersion depth of the gear within the oil pool. Alternately, this can be accomplished by substituting a higher density gas for air which has the same effect. In a third embodiment the immersed gear includes wind vanes that direct air against the oil pool creating a trough which effectively reduces the immersion depth of the gear within the oil pool. | 02-20-2014 |
20140030218 | Treatment And Screening - A method of treating a patient having an autoimmune disease or a Th1 polarising infection or a condition associated with inflammation other than asthma or allergy, the method comprising administering to the patient a therapeutically effective amount of an inhibitor of Interferon Regulatory Factor 5 (IRF5). | 01-30-2014 |
20130331722 | FEATURE CHARACTERIZATION FOR BREATHING MONITOR - A method of identifying a breath comprises sensing a signal generated by a living human or animal body and separating the signal into a plurality of frequency bands to identify a breath candidate. | 12-12-2013 |
20130330644 | REGENERATIVE FUEL CELLS - The present invention provides a regenerative fuel cell comprising an anionic membrane capable of selectively passing anions, wherein the pH of the anolyte and/or catholyte is at least 10. The present invention also relates to a method of operating a regenerative fuel cell comprising an anionic membrane capable of selectively passing anions, wherein the pH of the anolyte and/or catholyte is at least 10. | 12-12-2013 |
20130303443 | NOVEL COMPOUNDS AND THEIR EFFECTS ON FEEDING BEHAVIOUR - Peptide analogues of PYY, compositions comprising said analogues, and methods of using said analogues for the treatment and prevention of metabolic disorders, for example disorders of energy metabolism such as diabetes and obesity, and for reduction in appetite, reduction in food intake or reduction of calorie intake in a subject, are provided herein. | 11-14-2013 |
20130273350 | NANOCELLULOSE SURFACE COATED SUPPORT MATERIAL - The present invention relates to a process for the production of a surface coated support material wherein said process comprises contacting a support material with an aqueous dispersion of nanocellulose. The surface coated support material can be used in a composite material. The invention therefore further relates to the surface coated support material per se, a composite comprising the material, a process for the production of the composite material and an article produced from the composite material. | 10-17-2013 |
20130229156 | BATTERY MONITORING IN ELECTRIC VEHICLES, HYBRID ELECTRIC VEHICLES AND OTHER APPLICATIONS - A method for monitoring the condition of at least one cell of a battery, used in an electric or hybrid electric vehicle. The battery is connected to a power converter to supply electrical power to an electrical load. The method includes the steps of: controlling the power converter to vary the input impedance of the power converter to draw a varying current from the cell; sensing the voltage across the cell and the current drawn in response to varying the impedance of the power converter; calculating from the sensed voltage and current the complex impedance of the cell; and comparing the calculated complex impedance with information indicative of a correlation between (i) the complex impedance and (ii) information indicative of the condition of the cell, to give an indication of the condition of the cell. The varying current may be actively varied or passively varied. | 09-05-2013 |
20130225523 | GLYCODENDRIMERS OF POLYPROPYLETHERIMINE - A glycodendrimer comprising: a) a non-toxic dendrimer polypropyletherimine core supporting 16 terminal carboxylic acid groups, and b) conjugated to said core 2, 3, 4 or 5 glucosamine molecules, wherein each glucosamine is linked directly through a zero length amide bond with a residue of a terminal carboxylic acid group. The invention also extends to defined populations comprising said glycodendrimer molecules, pharmaceutical compositions comprising said molecules or populations, process for preparing the molecules and formulations, and therapeutic uses of the molecules, populations and compositions. | 08-29-2013 |
20130203073 | ASSAY FOR ANALYTES BASED ON AGGREGATION - The present invention relates to compositions, assay devices, kits and methods for detecting the presence, amount and/or activity of an analyte in a sample. In particular, the present invention relates to the detection of enzymes. The present invention also relates to methods of diagnosing diseases associated with dysregulation of enzymes, screening for modulators of enzymatic activity, candidate antimicrobial peptides and toxins. | 08-08-2013 |
20130190237 | METHODS FOR CATEGORISING CANCER SUCH AS BREAST CANCER - A method for aiding in categorising or determining prognosis in a patient with cancer, for example breast cancer (or, for example, hepatocellular, bladder or gastric cancer) or in selecting a therapeutic strategy for a patient with cancer, for example breast cancer (or, for example, hepatocellular, bladder or gastric cancer), the method comprising the step of assessing the level of LMTK3 nucleic acid, protein or activity in a sample obtained from the patient and/or assessing the patient's genotype for LMTK3, optionally at position rs8108419 (in intron 2 of the LMTK3 gene) and/or position rs9989661 (in intron 15 of the LMTK3 gene). The method may further comprise the step of assessing the level of ERa nucleic acid, protein or activity in a sample obtained from the patient, particularly in the case of breast cancer. If the level of LMTK3 nucleic acid, protein or activity in the sample is an elevated level and/or the genotype is LMTK3 rs8108419AA or LMTK3 rs9989661 CT or CC then the selected treatment regime may be an aggressive treatment regime or may comprise treating the patient with an inhibitor of LMTK3 activity and/or an inhibitor of Fox03a activity. If the level of LMTK3 nucleic acid, protein or activity in the sample is not elevated and/or the genotype is LMTK3 rs8108419GA or GG or LMTK3 rs9989661 TT then the selected treatment regime may be a less aggressive treatment regime. | 07-25-2013 |
20130171133 | CANCER METHODS - A method of treating a patient having a cancer in which HER2, HER4, FGFR1, EPHA2 and/or FGFR3 is upregulated and/or in which HER2, HER4, FGFR1, EPHA2 and/or FGFR3 mediated-signaling is upregulated, the method comprising administering to the patient a compound comprising or consisting of an OPCML polypeptide (SEQ ID NO: 1), or a fragment thereof which comprises at least one Ig domain of OPCML, or a variant thereof having at least 90% sequence identity with the OPCML polypeptide or the fragment thereof, or a nucleic acid molecule which encodes the OPCML polypeptide or fragment or variant thereof. | 07-04-2013 |
20130129636 | Novel Liposome Nanoparticles for Tumor Magnetic Resonance Imaging - The present invention provides novel liposomes comprising Gd.DOTA.DSA (gadolinium(III)2-{4,7-bis-carboxymethyl-10-[(N,N-distearylamidomethyl-N′-amido-methyl]-1,4,7,10-tetra-azacyclododec-1-yl}-acetic acid), characterised in that said liposome further comprises a neutral, fully saturated phospholipid component (e.g. DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine]), which are of particular use in the preparation of magnetic resonance contrast agents for enhancing a magnetic resonance image of tumours in a mammal. | 05-23-2013 |
20130125606 | METHOD OF FORMING A COMPONENT OF COMPLEX SHAPE FROM SHEET MATERIAL - Method of forming a component of complex shape from an Al-alloy sheet or a Mg-alloy sheet. The method includes the steps of: a) heating the sheet to a temperature below the solution heat treatment (SHT) temperature for the alloy; b) forming the heated sheet between heated dies into or towards the complex shape; c) heating the sheet to at least its SHT temperature and substantially maintaining that temperature until SHT has been completed; and d) quenching the solution heat treated sheet between cold dies and at the same time completing the forming into the complex shape or maintaining that shape. | 05-23-2013 |
20130118983 | ASYMMETRIC MEMBRANES FOR USE IN NANOFILTRATION - Improved integrally skinned asymmetric membranes for organic solvent nanofiltration, and their methods of preparation and use are disclosed. Membranes are formed from polybenzimidazoles by phase inversion and are then crosslinked by addition of crosslinking agents. These stabilise the membranes and allow solvent nanofiltration to be maintained even in the solvents from which the membranes were formed by phase inversion, and in strongly acidic and strongly basic solvents. | 05-16-2013 |
20130118260 | Ultrasonic Non-Destructive Testing - An apparatus and method for ultrasonic non-destructive testing provides an elongate strip of ultrasound transmissive material coupled at a proximal end to an object under test. The elongate strip has a transverse cross-section with a width and thickness giving an aspect ratio greater than unity and matched to the ultrasonic transducer such that excitation induces a substantially non-dispersive ultrasonic signal to propagate along the elongate strip to the proximal end and to enter the object under test. These non-dispersive pulses are particularly suited for time-of-flight measurements, thickness measurements, crack measurements and the like. The elongate strip helps to separate the transducer from a potentially hostile environment associated with the object under test. The elongate strip also has a large area of contact with the object under test allowing efficient transmission of energy into the object under test. | 05-16-2013 |
20130116206 | QUINOLINE DERIVATIVES USED AS PET IMAGING AGENTS - There is provided compounds of formula (I), wherein R | 05-09-2013 |
20130112619 | SOLVENT RESISTANT POLYAMIDE NANOFILTRATION MEMBRANES - The present invention relates to a composite membrane for nanofiltration of a feed stream solution comprising a solvent and dissolved solutes and showing preferential rejection of the solutes. The composite membrane comprises a thin polymeric film formed by interfacial polymerisation on a support membrane. The support membrane is further impregnated with a conditioning agent and is stable in polar aprotic solvents. The composite membrane is optionally treated in a quenching medium, where the interfacial polymerisation reaction can be quenched and, in certain embodiments, membrane chemistry can be modified. Finally the composite membrane is treated with an activating solvent prior to nanofiltration. | 05-09-2013 |
20130098158 | Ultrasonic Non-Destructive Testing - An apparatus and method for ultrasonic non-destructive testing provides an elongate strip of ultrasound transmissive material coupled at a proximal end to an object under test. The elongate strip has a transverse cross-section with a width and thickness giving an aspect ratio greater than unity and matched to the ultrasonic transducer such that excitation induces a substantially non-dispersive ultrasonic signal to propagate along the elongate strip to the proximal end and to enter the object under test. These non-dispersive pulses are particularly suited for time-of-flight measurements, thickness measurements, crack measurements and the like. The elongate strip helps to separate the transducer from a potentially hostile environment associated with the object under test. The elongate strip also has a large area of contact with the object under test allowing efficient transmission of energy into the object under test. | 04-25-2013 |
20130084299 | METHODS - The present invention provides method, uses and agents for preventing or reducing cognitive decline in a patient following a planned inflammatory trigger. Such planned inflammatory trigger can be a surgical procedure or chemotherapy. The invention further provides methods, uses and agents for reducing cognitive decline in a patient with a cognitive disorder, wherein said patient has been exposed to an inflammatory trigger. Pharmaceutical compositions and kits are also provided. | 04-04-2013 |
20130078654 | Methods For Diagnosing Rheumatoid Arthritis - The present invention relates to methods of diagnosing, prognosing, preventing or delaying onset of or treating rheumatoid arthritis, methods of distinguishing between different types or stages of rheumatoid arthritis, of identifying an individual at risk of developing rheumatoid arthritis, and of monitoring efficacy of a treatment regime in an individual being treated for rheumatoid arthritis, using a citrullinated enolase peptide to detect or capture antibodies associated with rheumatoid arthritis. | 03-28-2013 |
20130077965 | METHOD AND APPARATUS FOR OPTICALLY OUTPUTTING INFORMATION FROM A SEMICONDUCTOR DEVICE - A method of optically outputting information (e.g. digital data) from a semiconductor device, the method comprising: providing a semiconductor device having a semiconducting p-n junction, the p-n junction having a region of reduced free charge carrier density; applying an electrical signal to modulate the extent of the said region, the electrical signal being representative of the information to be outputted; arranging incident light to pass through at least part of the said region, such that the light is at least partially absorbed in dependence upon the modulated extent of the said region, thereby producing intensity-modulated output light; and detecting the intensity of the output light and thereby determining the outputted information. Also provided is an electro-optical assembly, a package module for mounting a semiconductor device on a printed circuit board, and an integrated circuit chip. | 03-28-2013 |
20130072691 | MEMBRANE ENHANCED POLYMER SYNTHESIS - This invention relates to the synthesis of polymers. More specifically, the present invention relates to the synthesis of heterobifunctional polymers and polymers with narrow and mono-disperse molecular weight distributions, and especially to the application of membranes to the synthesis of these polymers. | 03-21-2013 |
20130023757 | INTERCONNECT FOR AN MRI DETECTOR COIL MOUNTED ON A CATHETER - An interconnect for an RF detector coil comprises a substrate comprising strip of insulating material, a conducting layer formed on a first side of the substrate, and a ground layer formed on a second side of the substrate. At least one of the layers has a periodic pattern so that the conducting layer alternates along its length between capacitive regions which are opposite regions of the ground layer, and non-capacitive regions. | 01-24-2013 |
20120297507 | METHOD - A method for producing leafy biomass from undifferentiated plant cells, the method comprising providing undifferentiated plant cells, contacting them with an agent that promotes differentiation of the cells into leafy tissue and growing the cells in a temporary liquid immersion culture system. This method of the invention may be used to produce polypeptides, and natural medicinal products, and can be used to capture carbon dioxide. A method of producing a polypeptide in plant cells in vitro comprising: providing undifferentiated plant cells containing chloroplasts that carry a transgenic nucleic acid molecule encoding the polypeptide, wherein the plant cells display homoplastomy; and propagating the cells according to the above method to produce leafy biomass containing the polypeptide. | 11-22-2012 |
20120281900 | METHOD AND APPARATUS FOR PROCESSING MEDICAL IMAGES - A method of processing medical images, performed by a computer processor and comprising the steps of: (a) obtaining one or more atlases containing one or more images in which one or more anatomical features have been labelled with label data; (b) obtaining a plurality of unlabelled images; (c) comparing the labelled and unlabelled images and selecting one or more unlabelled images that most closely resemble(s) one or more of the labelled images; (d) to each of those selected image(s), propagating label data from one or more of the closest of the labelled images, thereby labelling the corresponding anatomical feature(s) of each of the selected image(s) and causing the selected image(s) to become labelled image(s); and (e) iteratively repeating from step (c), thereby labelling others of the unlabelled images. | 11-08-2012 |
20120277164 | GADD45BETA TARGETING AGENTS - Compounds based around tetrapeptide, tripeptide and dipeptide moeties and corresponding peptiod moeties. Related methods and pharmaceutical compositions for use in treatment of cancer, inflammatory diseases, and other disorders. | 11-01-2012 |
20120232519 | Glucagon pump controller - According to a first aspect of the present invention there is provided a controller for controlling a glucagon pump. The controller comprises an input | 09-13-2012 |
20120232014 | ANTITHROMBOTIC COMPOUNDS - A soluble compound for preventing or reducing blood coagulation comprising an antithrombotic agent and a membrane binding element, wherein the antithrombotic agent has a weight of less than about 5,000 daltons. Also disclosed is a soluble compound for preventing or reducing blood coagulation comprising an anticoagulant joined to a membrane binding element via a joining element, wherein the joining element between the anticoagulant and the membrane binding element is less than about 10,000 daltons in weight. These compounds can be used in therapy and, in particular, in preventing or reducing blood coagulation. As a result, a method of treatment is provided comprising administering an effective amount of the compounds to a subject to prevent or reduce blood coagulation as well as a method of perfusing an organ, tissue or cell comprising contacting the compounds with the organ, tissue or cell to prevent or reduce blood coagulation. Also disclosed is an organ, tissue or cell which has been perfused with the compounds. | 09-13-2012 |
20120213826 | Use of Pro-Inflammatory Compounds for Promoting Bone Formation - The present invention provides methods, uses and compounds for promoting bone formation in a patient at a site in need thereof by the provision of a pro-inflammatory compound at the site. The site is generally a site of injury or a site of surgical intervention in the patient. Exemplary compounds include pro-inflammatory: cytokines. Inhibitors of indoleamine 2, 3, dioxygenase 1 are also provided in the methods and uses of the invention. | 08-23-2012 |
20120156689 | METHOD AND APPARATUS FOR DETERMINING AN ANALYTE PARAMETER - A method of determining an analyte parameter is described for an analyte in a detection region having at least one analyte binding zone. The method includes detecting presence of an analyte element bound at the binding zone, incrementing or decrementing a count and preventing recount of the element to obtain absolute quantification. | 06-21-2012 |
20120132594 | AQUEOUS SOLVENTS FOR HYDROCARBONS AND OTHER HYDROPHOBIC COMPOUNDS - A method of solubilising in an aqueous medium a hydrocarbon or a hydrophobic compound having a hydrocarbon skeleton that carries one or more heteroatom-containing functional groups, e.g. hydroxyl, carboxylic acid or aldehyde (CHO) groups. The method comprises contacting the hydrocarbon or the hydrophobic compound with the aqueous medium that includes at least one non-ionic surfactant containing a hydrophilic part and a hydrophobic part, the hydrophilic part comprising a polyhydroxylated moiety and the hydrophobic part comprising a hydrocarbon chain containing at least 12 carbon atoms, e.g. ethoxylated sorbitol. The amount of surfactant used is sufficient to form micelles including a core formed of the hydrocarbon or the hydrophobic compound. | 05-31-2012 |
20120118242 | ABSORBENT MATERIAL - An absorbent composition is manufactured and used in cat litter. The composition includes: a particulate inorganic mineral, one or more superabsorbent polymers (SAP) dispersed between the particles of the mineral, and a hydrophilic binder capable of binding the mineral and the SAP into discrete granules. The granular material produced has water absorbency characteristics comparable to that of more expensive bentonite-products. The mineral may be waste quarry fines that would otherwise have to be disposed of. Such fines are widely available, in contrast to bentonite that must be shipped from a restricted number of locations, which is environmentally damaging and associated with excessive product miles. The granules can be made by mixing the mineral and the super absorbent polymer to form a slurry, draining the water from the slurry and optionally pressing the resulting filter cake, mixing the binder with the wet filter cake and granulating the resulting composition. | 05-17-2012 |
20120070852 | ASSAY - The present invention relates to an assay for transferases. The assay comprises a first moiety comprising a transferase substrate and a second moiety capable of binding to the transferase substrate after it has been acted on by the transferase. One of the first and second moieties comprises a fluorophore and the other of the first and second moieties causes a change in fluorescence of the fluorophore. Thus, when the second moiety binds the transferase substrate after it has been acted on by the transferase, a change in fluorescence can be detected. The assay allows for agents that modulate the activity of the transferase to be screened. | 03-22-2012 |
20120058597 | FABRICATION METHOD FOR THIN-FILM FIELD-EFFECT TRANSISTORS - A thin-film field-effect transistor is formed by forming a dielectric layer adjacent a gate, forming a source region and a drain region, and forming a semiconductor layer on the dielectric layer. The semiconductor layer is deposited by spray pyrolysis and comprises a material selected from a group comprising: oxides; oxide-based materials; mixed oxides; metallic type oxides; group I-IV, II-VI, III-VI, IV-VI, V-VI and VIII-VI binary chalcogenides; and group I-II-VI, II-II-VI, II-III-VI, II-VI-VI and V-II-VI ternary chalcogenides. | 03-08-2012 |
20120028881 | METHODS AND REAGENTS FOR DIAGNOSING ATHEROMA - The invention provides a method of diagnosing atheroma in an individual, the method comprising providing a sample from the individual, determining the level of lysozyme in the sample and assessing whether the level is indicative of atheroma in the individual. The invention also provides the use of a reagent which selectively identifies lysozyme in the assessment of atheroma in an individual. | 02-02-2012 |
20110274675 | Therapeutically Useful Molecules - A T cell receptor molecule (TCR) containing an alpha chain portion and a beta chain portion wherein the alpha chain portion contains three complementarily determining regions (CDRs): CDR1α: SSYSPS CDR2α: YTSAATL CDR3α: VVSPFSGGGADGLT or comprising or consisting of SPPSGGGADGLT and the beta chain portion contains three complementarity determining regions (CDRs): CDR1β: DFQATT CDR2β: SNEGSKA CDR3β: comprising SARDGGEG or comprising or consisting of RDGGEGSETQY, or wherein up to three amino acid residues in one or more CDRs are replaced by another amino acid residue. The invention also includes polynucleotides encoding the TCR molecules, and host cells containing the said polynucleotides. Patient derived T cells may have the polynucleotides encoding the TCR molecules introduced therein, and the engineered T cells may be introduced into the patient in order to combat a WT1-expressing malignancy. | 11-10-2011 |
20110262041 | KEYPOINT DESCRIPTOR GENERATION BY COMPLEX WAVELET ANALYSIS - The present invention relates to a method of generating a keypoint descriptor for identifying an object in an image or in a sequence of images, the keypoint descriptor being substantially invariant to a transformation of the object in the image. The method includes receiving object data representing an object for identification in an image; processing said object data to generate at least one basis function representing a feature having undergone at least one transformation or a transformation sequence across several consecutive frames, optionally using transformations that are out of the image plane to recognise objects from multiple views; modifying a prototype wavelet function based on said at least one basis function to generate a plurality of modified wavelet functions; comparing the plurality of modified wavelet functions with the at least one basis function; selecting a modified wavelet function of said plurality of modified wavelet functions based on the comparison of the plurality of modified wavelet functions with the at least one basis function; and processing an input image or input orientation field according to said selected modified wavelet function to generate the keypoint descriptor. The present invention further relates to a method of identifying an object in an image using a keypoint descriptor; and apparatus and computer software for implementing a method in accordance with the present invention. | 10-27-2011 |
20110261446 | OPTICAL ARRANGEMENT FOR OBLIQUE PLANE MICROSCOPY - An optical arrangement for oblique plane microscopy includes a first optical subassembly having an objective lens that receives light from a sample in use, and configured to produce an intermediate image of the sample, and a second optical subassembly focused on the intermediate image. Optical axes of the first and second subassemblies are at an angle to each other at the point of the intermediate image, such that the second subassembly images an oblique plane in the intermediate image, corresponding to an oblique plane in the sample. An oblique plane microscopy method is performed by directing an incident light beam through the objective lens to illuminate or excite the oblique plane in the sample, and receiving light from the sample through the same objective lens. The incident light beam is incident on the sample at an angle of substantially 90° relative to the light beam received from the sample. | 10-27-2011 |
20110245460 | SOLVENT RESISTANT DIAFILTRATION OF PEPTIDES, PNA OR OLIGONUCLEOTIDES - According to the present invention, there is provided a process for the preparation of a first compound selected from peptides, oligonucleotides and peptide nucleic acids. The process comprises synthesising the first compound and then separating the first compound formed in step (i) from a second compound, which is a reaction by-product of the synthesis of the first compound and/or an excess of a reagent used for the synthesis of a first compound by a process of diafiltration. The membrane used for the diafiltration process is stable in organic solvents and provides a rejection for the first compound which is greater than the rejection for the second compound. | 10-06-2011 |
20110245384 | Process for the production of a functionalised carbon nanomaterial - The invention provides a process for the production of a functionalised carbon (nano)material comprising heating a carbon (nano)material in an inert atmosphere to produce a surface-activated carbon (nano)material and incubating said surface-activated carbon (nano)material with a chemical species capable of reacting with the surface-activated carbon (nano)material. | 10-06-2011 |
20110236312 | NUCLEOSIDE ANALOGUES USEFUL AS POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS - The invention provides compounds that comprise a 4′-thio nucleoside that is a derivative of 4′-thiothymidine or 4′-thio-2′-deoxyuridine comprising a positron or single photon emitting radioisotope or corresponding non-radioactive isotope attached via a triazole link to the N-3 position. Methods for preparing such compounds and uses of the compounds in medicine are also provided. | 09-29-2011 |
20110224405 | DEGRADABLE SUPPORTS FOR TIDE SYNTHESIS - According to the present invention, there is provided a process for synthesis of a first compound selected from peptides, oligonucleotides, and peptide nucleic acids, which comprises synthesis of the first compound linked to a soluble support, wherein the soluble support is degraded following the synthesis so that it can be separated from the first compound. | 09-15-2011 |
20110210757 | APPARATUS AND METHOD TO MEASURE PROPERTIES OF POROUS MEDIA - A method to determine properties of a porous material, in which: a porous sample is prepared and sealed; first the sample is evacuated to near vacuum; then a non-wetting and electrically conducting fluid is passed through the sample at a known pressure and the volume of the fluid taken up by the sample is measured; then a small differential pressure is applied across the sample and the flow rate of the fluid through the sample is measured; and an alternating current is passed through the sample and the resistance across the sample is measured. | 09-01-2011 |
20110195024 | ISATIN DERIVATIVES FOR USE AS IN VIVO IMAGING AGENTS - Isatin 5-sulfonamide derivatives, pharmaceutical compositions comprising the derivatives, their use as molecular imaging agents, their use for the diagnosis or treatment of diseases or disorders associated with dysregulation of apoptosis, methods for synthesizing the derivatives, methods for the molecular imaging of caspase activity and apoptosis, and methods of assessing the therapeutic effect of a test substance on caspase activity are disclosed. | 08-11-2011 |
20110189669 | METHODS OF AIDING IN THE DIAGNOSIS OF PROSTATE CANCER - The current invention provides a method for aiding in the assessment of prostate cancer (including metastatic prostate cancer) and/or benign prostate hyperplasia in a patient, wherein the method comprises the step of determining the level of Glycine N-methyltransferase (GNMT) nucleic acid and/or protein in a sample from the patient. The invention also provides compounds that target Glycine N-methyltransferase (GNMT) protein and/or nucleic acid for use in treating prostate cancer. Also provided are screening methods for selecting a compound considered to be useful in treating prostate cancer, comprising the steps of determining the ability of a test compound to reduce GNMT activity and selecting a compound that reduces GNMT activity. The invention also provides methods for aiding in the diagnosis of prostate cancer in a patient comprising obtaining a sample from the patient and assessing said sample for a marker of GNMT activity. | 08-04-2011 |
20110144765 | Process For Producing Porous Scaffolds From Sinterable Glass - The invention relates to a process for producing a porous glass construct with interconnected porosity, the resulting porous construct and its use as a macroporous scaffold in bone repair and regeneration. | 06-16-2011 |
20110142902 | Hypoxia Inducing Factor (HIF) Stabilising Glasses - The present invention relates to a glass composition formulated to provide the controlled release of certain transition metal ions to regulate the cellular hypoxia pathway and the use of these hypoxia-pathway regulating glasses in medicine and in biomedical research, including in the repair, restoration or regeneration of diseased or damaged tissue. | 06-16-2011 |
20110137195 | Method and Apparatus for Monitoring Respiratory Activity - A method of monitoring respiratory activity includes obtaining a respiration sound signal. The respiration sound signal is processed to identify a frequency component corresponding to respiration, and an amplitude related parameter of the component is measured. If the measured parameter is in an indeterminate region then a temporal domain related parameter of the identified frequency component is measured. An apparatus for monitoring respiratory activity is also disclosed. | 06-09-2011 |
20110137126 | ENDOSCOPE - An endoscope includes a light source operable to generate coherent incident light, and a plurality of imaging optical fibres that are arranged in a fibre bundle, arranged to receive light at a proximal end of the fibre bundle, and arranged to transmit light to a distal end of the fibre bundle. The endoscope further includes a spatial light phase modulator between the light source and the fibre bundle, and arranged to receive the incident light from the light source and to adjust the relative phase of the incident light entering each of the plurality of imaging optical fibres. | 06-09-2011 |
20110131690 | Scanning Ion Conductance Microscopy - The subject invention concerns methods for interrogating a surface using scanning ion conductance microscopy (SICM). In one embodiment, a method of the invention comprises the steps of:
| 06-02-2011 |
20110123592 | Biomaterials - The invention relates to a biomaterial having a latent form of a growth factor immobilised thereon, and to a method of producing the biomaterial, comprising immobilising the latent form of the growth factor on the biomaterial. The biomaterial may be used in medicine, such as in tissue regeneration or repair. | 05-26-2011 |
20110118435 | BIMETALLIC CATALYTIC COMPLEXES FOR THE COPOLYMERISATION OF CARBON DIOXIDE AND AN EPOXIDE - The present invention provides a novel catalyst of formula (I): wherein M is selected from Zn(H), Co(II), Mn(II), Mg(II), Fe(II), Cr(III)-X or Fe(III)-X, and the use thereof in polymerising carbon dioxide and an epoxide. | 05-19-2011 |
20110113859 | LOW-VOLTAGE THIN-FILM FIELD-EFFECT TRANSISTORS - A low-voltage thin-film field-effect transistor is formed by forming a gate, forming a dielectric layer on the surface of the gate, forming a source region and a drain region, and forming a semiconductor layer adjacent the dielectric layer. The dielectric layer is formed as a native oxide layer by oxidizing the surface of the gate. The semiconductor layer is deposited by spray pyrolysis. The dielectric layer may be functionalized with a self-assembling monolayer dielectric layer. The dielectric layer may be formed as a self-assembling monolayer, without first forming a native oxide (or other) dielectric layer. | 05-19-2011 |
20110080802 | FLUID FLOW MODIFICATION APPARATUS - A fluid flow modification apparatus for creating turbulence in a moving fluid includes turbulence-creating elements arranged in a fractal configuration, each element having a first surface portion against which the fluid can flow and a second surface portion along which the fluid can flow, and further includes an insert for arrangement to obstruct the flow of fluid between adjacent second surface portions of at least two turbulence-creating elements. A support holds the turbulence-creating elements in the fluid to allow movement of the fluid relative to the turbulence-creating elements and the insert. The insert may be attachable to at least two turbulence-creating elements, such that the arrangement of the inserts is symmetrical about a centre point of the fluid flow field for improved mixing. | 04-07-2011 |
20110077380 | CARBOHYDRATE LACTONE POLYMERS - The present invention relates to a novel carbohydrate lactone, functionalized aliphatic polyesters and copolymers formed therefrom, and processes for the preparation thereof from renewable resources. | 03-31-2011 |
20110053239 | METHODS - A method of pre-treating lignocellulosic and cellulosic biomass for utilization of carbohydrate or lignin from the biomass, the method comprising the steps of inoculating the lignocellulosic biomass with lignocellulose degrading brown rot fungus and incubating the inoculated biomass under conditions in which growth of the lignocellulose degrading brown rot is promoted. The incubation may be under conditions in which growth of the lignocellulose degrading brown rot is promoted is terminated after less than 50 days or before substantial depletion of glucose in the biomass occurs. | 03-03-2011 |
20110034374 | Oxyntomodulin for Preventing or Treating Excess Weight - Compositions and methods for use in the prevention or treatment of excess weight in a mammal have been developed. The compositions comprise oxyntomodulin which is shown to reduce food intake. | 02-10-2011 |
20110021701 | MATERIAL COMPRISING MICROBIALLY SYNTHESIZED CELLULOSE ASSOCIATED WITH A SUPPORT LIKE A POLYMER AND/OR FIBRE - The invention relates to a material comprising cellulose in association with a support selected from a polymer and/or a fibre, wherein said cellulose is produced by a micro-organism. The cellulose-reinforced material is provided for incorporation into a composite. | 01-27-2011 |
20110021420 | MODIFICATION OF FEEDING BEHAVIOUR - The present invention relates to compositions and methods for use in the prevention or treatment of excess weight in a mammal. The compositions comprise oxyntomodulin which is shown to reduce food intake and/or increase energy expenditure. | 01-27-2011 |
20110016976 | ULTRASONIC NON-DESTRUCTIVE TESTING - An apparatus and method for ultrasonic non-destructive testing provides an elongate strip of ultrasound transmissive material coupled at a proximal end to an object under test. The elongate strip has a transverse cross-section with a width and thickness giving an aspect ratio greater than unity and matched to the ultrasonic transducer such that excitation induces a substantially non-dispersive ultrasonic signal to propagate along the elongate strip to the proximal end and to enter the object under test. These non-dispersive pulses are particularly suited for time-of-flight measurements, thickness measurements, crack measurements and the like. The elongate strip helps to separate the transducer from a potentially hostile environment associated with the object under test. The elongate strip also has a large area of contact with the object under test allowing efficient transmission of energy into the object under test. | 01-27-2011 |
20110009511 | Glass Polycarboxylate Cements - The present invention relates to glass compositions for use in formation of polycarboxylate cements and polycarboxylate cements comprising these glasses, wherein the glasses comprise SiO | 01-13-2011 |
20110009327 | BIOACTIVE NANOCOMPOSITE MATERIAL - The present invention relates to a porous inorganic/organic hybrid nanoscale composite comprising an enzymatically biodegradable organic polymer and a sol-gel derived silica network, its production and use as a macroporous scaffold in tissue engineering. | 01-13-2011 |
20100293942 | PASSIVELY CONTROLLED TURBOCHARGER - A flow control device for a turbocharger, the flow control device comprising a variably restricting flow restrictor for restricting flow in a turbocharger inlet by a variable amount, the flow control device being arranged such that the flow restrictor position varies flow restriction in response to force acting on a surface of the flow restrictor caused by a pressure pulse in a flow direction, the flow restrictor being biased in a direction opposed to the flow direction. | 11-25-2010 |
20100280399 | METHOD OF AND APPARATUS FOR GENERATING A MODEL OF A CARDIAC SURFACE HAVING A PLURALITY OF IMAGES REPRESENTING ELECTROGRAM VOLTAGES - A method of generating a model of a cardiac surface having a plurality of images representing electrogram voltages for a plurality of measured points within a heart comprises measuring an electrogram voltage at a plurality of points within a heart, generating a first model of a cardiac surface of the heart, generating an image representing each electrogram voltage, each image having a characteristic representative of the electrogram voltage, and generating a further model of a cardiac surface. The images representing the electrogram voltages protrude from the further model of the cardiac surface at points on the further model corresponding to the points at which the electrogram voltages were measured. There is also disclosed an apparatus for generating a model of a cardiac surface. | 11-04-2010 |
20100276342 | METHOD OF FROTH FLOATION CONTROL - A method of controlling operation of a froth floatation cell for separating substances comprises introducing gas into liquid in the cell, creating a froth controlling gas flow rate into the cell in order to maximise gas recovery for the cell. | 11-04-2010 |
20100273750 | SEROTONIN RECEPTOR ANTAGONISTS FOR TREATING ARTHRITIS - The present invention relates to serotonin receptor antagonists for treating inflammatory arthritis and related conditions. The present invention also relates to a kit comprising a pharmaceutical composition comprising a serotonin receptor antagonist and instructions indicating that the composition is for use in treating inflammatory arthritis and related conditions. In addition, the present invention relates to a method of treating inflammatory arthritis and related conditions comprising administration of a serotonin receptor antagonist. The method is preferably carried out on a subject in need of treatment. The inflammatory arthritis is preferably rheumatoid arthritis. | 10-28-2010 |
20100198051 | ACTUATORS - An actuator comprises an input shaft ( | 08-05-2010 |
20100177163 | NON PHOTOREALISTIC RENDERING OF AUGMENTED REALITY - A method and system for rendering a captured image of a scene is disclosed which provide see-through vision through the rendered image, for example of an augmented reality object rendered behind the scene, by assigning pixel transparency values in dependence upon captured image pixels. The method and system preserve some structure of the scene in the rendered image without requiring a model of the scene. | 07-15-2010 |
20100163808 | HIGHLY CONDUCTIVE AND STABLE TRANSPARENT CONDUCTING POLYMER FILMS - The invention relates to a process for the synthesis of conducting polymer films by vapour phase polymerization. The invention relates particularly to the synthesis of polymerized thiophene films, for example poly(3,4-ethylenedioxythiophene) (PEDOT) films. | 07-01-2010 |
20100152849 | RETINAL PROSTHETIC DEVICES - A retinal prosthetic device comprises image capture means ( | 06-17-2010 |
20100113948 | HEART RATE MEASUREMENT - A reflective photoplethysmograph sensor (for example mounted in an earpiece) arranged for photoplethysmograph measurements behind a subject's ear is provided. Also provided is a wearable photoplethysmograph heart rate sensor which includes a plurality of radiation detectors defining respective sensing planes which are tilted with respect to each other. Further there is provided a photoplethysmograph heart rate sensing system which compensates for motion artefacts using a dark signal which may be derived during an off phase of a duty cycle of an emitter and a photoplethysmograph system arranged to select between a plurality of detectors based on a quality measure. Combinations of the systems and sensors are also disclosed. | 05-06-2010 |
20100092459 | Protein Complex and Uses - The present invention relates to a complex comprising two or more of the proteins S6K2, PKCε and B-Raf. The invention also relates to antibodies that specifically bind to the complex, inhibitors of the complex and uses of the antibodies, inhibitors and complex in diagnosing and preventing chemoresistance in a patient. | 04-15-2010 |
20100069321 | Biological Materials and Uses Thereof - The invention relates to the modification of proteins to improve their, biochemical, immunological or biophysical properties, in turn leading to such proteins having increased diagnostic, biotechnological or therapeutic benefit. In particular the invention relates to polysialylation of proteins or conjugates of proteins. There is also provided, nucleotide sequences and expression vectors encoding, host cells expressing, compositions comprising and uses of the polysialylated molecules of the invention. | 03-18-2010 |
20100059755 | IMPROVED OXIDE-BASED FIELD-EFFECT TRANSISTORS - A field-effect transistor includes a source region; a drain region; a semiconductor layer disposed between the source and drain regions; a gate region; and a dielectric region disposed between the semiconductor layer and the gate region. The semiconductor layer comprises a titanium dioxide film. The transistor may be light sending, gas- or bio-sensing, or used in a visual display or in electronic circuits. The transistor is formed by forming a dielectric layer adjacent a gate region; forming a source region and a drain region; and forming a semiconductor layer on the dielectric layer, the semiconductor layer comprising titanium dioxide. The titanium dioxide semiconductor layer may be deposited by spray pyrolysis, or alternatively mesoporous TiO | 03-11-2010 |
20100058869 | ULTRASONIC NON-DESTRUCTIVE TESTING - An apparatus and method for ultrasonic non-destructive testing provides an elongate strip of ultrasound transmissive material coupled at a proximal end to an object under test. The elongate strip has a transverse cross-section with a width and thickness giving an aspect ratio greater than unity and matched to the ultrasonic transducer such that excitation induces a substantially non-dispersive ultrasonic signal to propagate along the elongate strip to the proximal end and to enter the object under test. These non-dispersive pulses are particularly suited for time-of-flight measurements, thickness measurements, crack measurements and the like. The elongate strip helps to separate the transducer from a potentially hostile environment associated with the object under test. The elongate strip also has a large area of contact with the object under test allowing efficient transmission of energy into the object under test. | 03-11-2010 |
20100047256 | METHODS - The present invention relates to methods of diagnosing, prognosing, preventing or delaying onset of or treating rheumatoid arthritis, methods of distinguishing between different types or stages of rheumatoid arthritis, of identifying an individual at risk of developing rheumatoid arthritis, and of monitoring efficacy of a treatment regime in an individual being treated for rheumatoid arthritis, using a citrullinated enolase peptide to detect or capture antibodies associated with rheumatoid arthritis. | 02-25-2010 |
20100038306 | ASYMMETRIC MEMBRANES FOR USE IN NANOFILTRATION - Improved integrally skinned asymmetric membranes for organic solvent nanofiltration, and their methods of preparation and use are disclosed. Membranes are formed from polyimides by phase inversion and are then crosslinked by addition of amine crosslinking agents that react with the imide groups of the polyimide, creating amide bonds. These stabilise the membranes and allow solvent nanofiltration to be maintained even in the solvents from which the membranes were formed by phase phase inversion. | 02-18-2010 |
20100030295 | Apparatus and method for programming a pacemaker - A pacemaker programming apparatus for programming a pacemaker in an individual. The apparatus comprises means for determining the sensed-paced difference of the pacemaker in the individual: first testing means for determining the optimum AV delay while the pacemaker is atrially pacing at a raised at a heart rate; and calculation means for calculating the optimum AV delay determined by the first testing means minus the sensed-paced difference. | 02-04-2010 |
20090318342 | Compounds - A mutant TIMP-3 (Tissue Inhibitor of MetalloProteinase-3) polypeptide wherein an additional residue or residues, for example an alanine residue, precedes the N-terminal residue of the TIMP-3 polypeptide; or wherein the residue corresponding to Threonine2 of TIMP-3 is mutated to Glycine. Such a mutant is considered to retain activity as an inhibitor of ADAMs, such as TACE, ADAMTS-4 and ADAMTS-5, but to have reduced activity as an inhibitor of MMPs. | 12-24-2009 |
20090308124 | AEROFOIL MEMBER - An aerofoil member ( | 12-17-2009 |
20090304663 | USE OF GSK-3 INHIBITORS FOR THE TREATMENT OF PROSTATE CANCER - A method of combating prostate cancer in a mammalian individual, the method comprising administering an inhibitor of glycogen synthase kinase-3 (GSK-3), or a polynucleotide which encodes an inhibitor of GSK-3, to the individual. A further anti-cancer agent can also be administered. Use of an inhibitor of GSK-3, or a polynucleotide which encodes an inhibitor of GSK-3, in the preparation of a medicament for combating prostate cancer. The medicament may contain a further anti-cancer agent. | 12-10-2009 |
20090299430 | Method and device for stabilising disordered breathing - A device and method for improving the stability of a ventilation pattern of a patient ( | 12-03-2009 |
20090298757 | OXYNTOMODULIN ANALOGUES AND THEIR EFFECTS ON FEEDING BEHAVIOUR - Compounds of the invention are novel peptide analogues of oxyntomodulin (oxm) in which one or more amino acids of the oxm sequence have been changed. Changing amino acids 15-24 of oxm to either amino acids 968-977 of the α-latrotoxin peptide (and variations thereof) or amino acids 15-24 of exendin-4 (and variations thereof), or combinations of sequences from these sources, and/or changing amino acids 27-33 of oxm to amino acids 27-33 of exendin-4, and/or the addition of amino acids to the C-terminus of the peptide, results in a series of analogues of oxm that demonstrate the oxm like activity of reducing food intake, and with certain embodiments a greater ability to decrease food intake. | 12-03-2009 |
20090292345 | METHOD AND APPARATUS FOR MEASURING ACTIVITY IN THE PERIPHERAL NERVOUS SYSTEM - A method and apparatus for measuring activity in the peripheral nervous system comprises a nerve cuff having an array of chemical detectors such as chemFETS or ISFETS. Activity within the nerve causes chemical responses which can be detected. The use of chemical rather than electrical detection minimises interference problems and allows the cuffs to be made smaller. | 11-26-2009 |
20090268200 | APPARATUS AND METHOD FOR OBTAINING SPECTRAL INFORMATION - A method of obtaining spectral information comprises initiating at least a first excitation at a first excitation frequency and a second excitation at a second frequency in a surface enhanced sample. The method further comprises varying one of said first and second excitation frequencies, detecting an output signal having an output signal strength and identifying an output signal peak. In addition the method includes correlating the identified output signal with the first and second excitation frequencies to obtain spectral information, in which the surface enhanced sample substrate is configured to enhance the field corresponding to at least one of the first and second excitation, or output fields initiated in this sample. | 10-29-2009 |
20090239250 | METHOD FOR THE ANALYSIS OF CELLS - The present invention provides an improved method of analysing and obtaining reliable data about the plasma membrane of single cells, using a microfluidic cell analyser. The microfluidic cell analyser of the invention comprises a single cell trap, a manipulator arranged to manipulate the outer surface of a cell in the trap, a detection zone in communication with the single cell trap and a detector. | 09-24-2009 |
20090232180 | METHOD AND APPARATUS FOR COHERENTLY COMBINING LASER EMISSION - A laser system comprises first and second laser sub-cavities each including a gain medium arranged to produce volume gain gratings. The laser system further includes a beam combiner arranged to combine emission from each cavity and direct emission from one cavity to the other. As a result a stale, phase-locked coherently combined emission system is provided. | 09-17-2009 |
20090218527 | Confocal Microscopy with a Two-Dimensional Array of Light Emitting Diodes - A confocal microscope | 09-03-2009 |
20090215682 | Modified PYY (3-36) Peptides and Their Effects on Feeding Behaviour - The present invention relates to compounds of formula (1); variants or derivatives thereof, or salts or solvates thereof. The present invention also relates to the use of such compounds to control appetite, feeding, food intake, energy expenditure and calorie intake, particularly in the treatment of obesity. | 08-27-2009 |
20090208462 | Methods of Treatment - The invention concerns the use of a nucleic acid encoding a photoactivator in the manufacture of a medicament for inducing photosensitivity in neuronal cells. In particular, the invention concerns the induction of photosensitivity in retinal ganglion cells (RGCs) for restoring sight and/or alleviating blindness in an individual. The invention further concerns vectors, cells and pharmaceutical compositions therefor. | 08-20-2009 |
20090208428 | Bioactive Glass - The present invention relates to a bioactive glass comprising strontium and silicon dioxide, processes for the production of the bioactive glass and the use of the bioactive glass in medicine. | 08-20-2009 |
20090069846 | TENDON REPAIR - An assembly is described for repairing torn tendons by reattaching them to a bone, in particular although not exclusively for repairing a torn rotator cuff tendon, which allows for reduction of the gap between the tendon and the humerus by pushing the tendon onto its attachment site. Also described is a method of repairing a torn rotator cuff tendon by pushing it onto its attachment site and suturing through the humeral head. | 03-12-2009 |
20090030350 | GAIT ANALYSIS - A method and system for analysing gait patterns of a subject by measuring head acceleration in vertical direction. The system comprises an accelerometer mounted on the head of the subject. The analysis includes calculating a signature from the acceleration data, using a Fourier transform, including energy of the first harmonics and comparing the signature with the baseline signature. Baseline signature is a representative of previously stored signatures. The comparison is done in order to monitor changes in the gait signatures over time. The entropy of the signatures may be used to perform the comparison. A self organised map is used to classify the measured gait signals. | 01-29-2009 |
20090030275 | Imaging System - A monoscopic imaging system, for example a minimally invasive surgery imaging system, is provided which includes an image capture device for capturing images of a monoscopic, for example endoscopic, field of view, an auxiliary light source operable such that an object within the field of view casts a shadow, an image processor operatively connected to the image capture device and operable to detect shadow pixels in the images corresponding to the shadow and to enhance the shadow in the images. The system is of particular, although not exclusive, application to laparoscopic surgery. | 01-29-2009 |
20080301071 | Support Vector Inductive Logic Programming - A computer implemented method of particular, although not exclusive application to analysing a plurality of molecules which comprises computing a kernel function for each pair of the plurality of molecules, the kernel function being representative of the number of features present in both molecules of the pairs and using the kernel function in a kernel based learning algorithm to model the relationship between the features and a property of the molecules. The method is also applicable to predicting a numerical value representing a characteristic of a molecule and, more generally, modelling instances of data in a database. A particular, although again not exclusive application, is the prediction of toxicity of a molecule. | 12-04-2008 |
20080300502 | Method Of Correlating Internal Tissue Movement - Internal tissue movement is correlated with the external body surface movement by tracking external surface movement at a plurality of surface point ( | 12-04-2008 |
20080299131 | Anti-Viral Compositions - The invention provides a composition comprising for simultaneous, sequential or separate administration a) a polyanion; and b) an antibody reactive against an antigen on the surface of an intracellular form of a virus, which virus has an extracellular form that is surrounded by one lipid membrane more than the intracellular form. The present inventors have found that the compositions according to the invention comprising an antibody and a polyanion can neutralize virus infectivity more efficiently than other compositions reported hitherto. | 12-04-2008 |
20080291444 | Method of Spectroscopy - A method of multidimensional spectroscopy has a controllable excitation source parameter and comprises controlling said controllable parameter to excite a vibrational mode of the sample, generating a homodyne reflected signal from the sample and obtaining a spectrum of the sample from the reflected signal. | 11-27-2008 |
20080291441 | Spectroscopic Support - A porous sample support provides a matrix into the pores or interstitial spaces of which a sample to be subjected to a spectroscopic analysis can be introduced. 2 D infrared spectroscopy can then be carried out on the sample at higher concentrations with minimized background. | 11-27-2008 |
20080288493 | Spatio-Temporal Self Organising Map - A method of classifying a data record as belonging to one of a plurality of classes, the data records comprising a plurality of data samples, each sample comprising a plurality of features derived from a value sampled from a sensor signal at a point in time, the method including: defining a selection variable indicative of the temporal variation of the sensor signals within a time window; defining a selection criterion for the selection variable; comparing a value of the selection variable to the selection criterion to select an input representation for a self organising map, the map having a plurality of input and output units, and deriving an input from the data samples within the time window in accordance with the selected input representation; and applying the input to a self organising map corresponding to the selected input representation and classifying the data record based on a winning output unit of the self organising map. | 11-20-2008 |
20080269325 | Methods to Relieve Pain - The invention is directed to a method of providing pain relief to a patient by administering to the patient an effective amount of a compound of Formula (I), which is represented by as RC(O)—NH—(CH | 10-30-2008 |
20080228118 | Joint Brace - A joint brace, for example a shoulder brace, includes one or more straps ( | 09-18-2008 |
20080199262 | Powder Injection Microchip - The present invention relates to a powder injection microchip, and a method of injecting powder using said powder injection microchip, wherein the microchip comprises a vibratable member associated with a powder inlet to a powder flow channel, wherein the vibration of the vibratable member allows the interparticle forces within cohesive powders to be overcome, resulting in the fluidisation of the powder. A powder inlet orifice with a dimension restricted relative to a powder flow channel dimension, and at least one gas flow channel in fluid connection with a powder flow channel downstream of a powder inlet orifice, are also disclosed. | 08-21-2008 |