National Institute of Health Patent applications |
Patent application number | Title | Published |
20160106871 | NOVEL PEPTIDE HYDROGELS GENERATING CHEMICAL EXCHANGE SATURATION TRANSFER MRI CONTRAST AND USES THEREOF - The present invention provides novel hydrogels through peptides, which are designed to self-assemble and produce magnetic resonance (MR) contrast through chemical exchange saturation transfer (CEST). The location and integrity of these gels could consequently be tracked using MR imaging. The self-assembly of the peptides into hydrogels can be brought about by a change in pH, ionic strength, temperature, and concentration of ions. | 04-21-2016 |
20150309026 | METHODS OF SCREENING FOR CELL PROLIFERATION OR NEOPLASTIC DISORDERS - The invention relates to methods and compositions for identifying subjects having, or predisposed to having, a neoplastic or cell proliferation or neoplastic disorder. The methods are applicable to any type of tissue sample and can be conducted on otherwise normal tissue. | 10-29-2015 |
20140256821 | INTRANNASAL ADMINISTRATION OF KETAMINE TO TREAT DEPRESSION - Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent or chronic depressive symptoms (>2 years). | 09-11-2014 |
20130143949 | G-CSF Transferrin Fusion Proteins - A polypeptide comprising a G-CSF domain operably linked to a Tf domain, wherein the ability of the polypeptide to be transported into a cell expressing a TfR gene or the ability of the polypeptide to be transported across a cell expressing a TfR gene via transcytosis is higher than that of the G-CSF domain alone. | 06-06-2013 |
20130143770 | CELLULAR ARRAYS AND METHODS OF DETECTING AND USING GENETIC DISORDER MARKERS - A method is disclosed for rapid molecular profiling of tissue or other cellular specimens by placing a donor specimen in an assigned location in a recipient array, providing copies of the array, and performing a different biological analysis of each copy. The results of the different biological analyses are compared to determine if there are correlations between the results of the different biological analyses at each assigned location. In some embodiments, the specimens may be tissue specimens from different tumors, which are subjected to multiple parallel molecular (including genetic and immunological) analyses. The results of the parallel analyses are then used to detect common molecular characteristic of the genetic disorder type, which can subsequently be used in the diagnosis or treatment of the disease. The biological characteristics of the tissue can be correlated with clinical or other information, to detect characteristics associated with the tissue. | 06-06-2013 |
20130089526 | Methods for Using Synthetic Triterpenoids in the Treatment of Bone or Cartilage Diseases or Conditions - The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions. | 04-11-2013 |
20110313279 | QUANTITATIVE OXYGEN IMAGING SYSTEMS AND METHODS USING ECHO-BASED SINGLE POINT IMAGING - An echo-based single point imaging (ESPI) system ( | 12-22-2011 |
20090148382 | Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof - One aspect of the invention relates to complexes of technetium (Tc) and rhenium (Re) with various heteroaromatic ligands, e.g., quinolinyl and isoquinolinyl ligands, and their use in fluorescence and radioimaging for a variety of clinical diagnostic applications, as well as radiopharmaceuticals for therapeutic applications. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium and rhenium complexes are also described. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention. | 06-11-2009 |