The General Hospital Corporation Patent applications |
Patent application number | Title | Published |
20160138077 | MONITORING AND ASSESSING DEACETYLASE ENZYME ACTIVITY - Disclosed herein are compounds and methods for detecting enzyme activity. In some embodiments, the enzyme is a deacetylase enzyme such as HDAC. The compound of the invention comprises a detectable label, a linker, and an enamide group. The compound can be enzymatically cleaved by the enzyme of interest to produce a nucleophilic fragment that includes the detectable label. Measurement of a signal generated by the detectable label can indicate enzyme activity. The compounds can be used as either in vivo or in vitro enzyme probes. | 05-19-2016 |
20160136070 | METHODS AND COMPOSITIONS FOR ENHANCING SKIN PIGMENTATION - Described herein are methods and compositions useful for enhancing pigmentation, such as skin, eye and/or hair pigmentation comprising administering e.g., an NNT inhibitor or an agent that modifies redox status in a melanocyte. | 05-19-2016 |
20160130658 | METHODS FOR DETECTING AND TREATING VARIANTS OF SEBORRHEIC KERATOSES - Disclosed herein are assays and methods for distinguishing a keratoacanthoma from squamous cell carcinoma. Methods for diagnosing a keratoacanthoma are also provided. Methods for treating variants of seborrheic keratoses (i.e., keratoacanthoma, acanthosis nigricans, or epidermal nevus) are also provided. | 05-12-2016 |
20160124059 | SUBJECT-LOADED HELICAL-ANTENNA RADIO-FREQUENCY COIL FOR MAGNETIC RESONANCE IMAGING - Example devices and methods of MRI scanning are disclosed herein. In an example, an MRI scanning system may include a structure defining a bore within which a subject is to be positioned for scanning. The system may also include a magnet to generate a primary magnetic field within the bore parallel to a longitudinal axis of the bore, and a helical-antenna radio-frequency (RF) coil oriented along the longitudinal axis to surround the subject. In addition, the system may include an RF signal generator to drive the helical-antenna RF coil to generate a circularly polarized (CP) RF magnetic field perpendicular to the longitudinal axis, as well as an RF detector to detect a response signal generated by tissues of the subject in response to the CP RF magnetic field. Also included may be a computing system to create an image of the tissues of the subject based on the detected response signal. | 05-05-2016 |
20160121002 | Bioorthogonal Turn-on Probes - This present application relates to fluorescent tetrazine-containing compounds consisting of a single pi-system. For example, a compound of Formula (I): or a salt thereof, wherein: F is a fluorophore, L is a conjugated linker, and Tz is a substituted or unsubstituted tetrazine; wherein the linker bridges the Tz and F moieties in a single conjugated pi-system. Also provided herein are methods of using the compounds provided herein for biomedical imaging. | 05-05-2016 |
20160116474 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING GLIOBLASTOMA - The present invention provides compositions and methods for the diagnosis and treatment of glioblastoma, particularly tumor propagating cells within the glioblastoma. | 04-28-2016 |
20160116472 | BIOMARKERS FOR STROKE DIAGNOSIS - Disclosed herein are assays and methods of diagnosing strokes using glycogen phosphorylase-BB (GPBB) as the biomarker. Specifically, assays and methods are described herein for distinguishing an ischemic brain condition from myocardial infarction, or distinguishing an ischemic brain condition from stroke mimics, or distinguishing an ischemic stroke from a hemorrhagic stroke. The diagnostic results offered by these assays and methods allow early and appropriate treatment for the specific condition. Also disclosed is a method to identify whether a subject having an ischemic stroke exhibits salvageable brain tissue. | 04-28-2016 |
20160077115 | ASSAYS AND METHODS OF TREATMENT RELATING TO VITAMIN D INSUFFICIENCY - Described herein are assays directed to determining the level of bioavailable or free vitamin D in a blood sample in a subject. The values determined for bioavailable or free vitamin D indicate whether the subject suffers from insufficient levels of vitamin D. Also described herein are methods of treatment for vitamin D insufficiency. | 03-17-2016 |
20160052890 | COMPOUNDS USEFUL AS ANTIBIOTIC TOLERANCE INHIBITORS - The disclosure provides compounds and pharmaceutical compositions of the compounds useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds and salts of general Formula VIII Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of | 02-25-2016 |
20160038091 | REMOVING ELETROPHYSICOLOGIC ARTIFACTS FROM A MAGNETIC RESONANCE IMAGING SYSTEM - Systems and a method for reducing periodic artifacts in an electrophysiologic signal are provided. The method includes receiving a time-series electrophysiologic signal acquired from a subject and providing a regression model that defines an interference signal caused by periodic artifacts using a harmonic representation. The method also includes applying the regression model using the time-series electrophysiologic signal to define a cost function and performing an iterative optimization process to estimate regression parameters that minimize the cost function. The method further includes determining, using the regression parameters, the interference signal, and generating a corrected time-series electrophysiologic signal by reducing the interference signal. | 02-11-2016 |
20160032401 | Glycine, Mitochondrial One-Carbon Metabolism, and Cancer - Methods of treatment, diagnosis, and determining prognosis of subjects with cancer, generally comprising determining levels of glycine metabolism or a mitochondrial 1-carbon (1-C) pathway enzyme, e.g., SHMT2, MTHFD1L, or MTHFD2, and optionally administering an antifolate or an agent that inhibits a mitochondrial 1-carbon (1-C) pathway enzyme, e.g., SHMT2 or MTHFD2. | 02-04-2016 |
20160029894 | METHODS AND SYSTEM FOR CHARACTERIZING AN OBJECT - Exemplary system, method and computer accessible medium are provided for determining at least one characteristic of a target object located behind or within a medium. For example, it is possible to identify a reference object that is located behind or within the medium. The target object and the reference object can be irradiated via a surface of the medium using at least one electromagnetic wave. At least one acoustic signal provided from an irradiated tissue volume that is responsive to the electromagnetic wave(s) can be measured. Calibration information can be obtained from the acoustic signal measured from the reference object based on at least one known property of the reference object. Then, the characteristic(s) of the target object can be determined based on the calibration information and the acoustic signal from the target object. | 02-04-2016 |
20160022841 | METHOD FOR AUGMENTING VISION IN PERSONS SUFFERING FROM PHOTORECEPTOR CELL DEGENERATION - The invention provides compositions and methods of treating subjects afflicted with a photoreceptor disorder. Methods for treating a subject suffering from a disorder characterized by photoreceptor cell degeneration are provided, wherein a gene encoding a photosensitive protein is introduced into a retinal cell of a subject. In one aspect of the invention, the retinal cells which receive the photosensitive protein include non-photoreceptor cells such as horizontal cells, amacrine cells, bipolar cells, and ganglion cells. | 01-28-2016 |
20160022817 | Photoswitchable HDAC Inhibitors - This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same. Provided herein are inhibitors of HDAC having photoswitchable modulators of protein function with short thermal relaxation kinetics. The compounds are diazo compounds including a substituted or unsubstituted aryl or heteroaryl ring, wherein at least one of the rings is substituted with one or more HDAC targeting elements. | 01-28-2016 |
20160002736 | USE OF MICROVESICLES IN ANALYZING NUCLEIC ACID PROFILES - The invention concerns gene signatures obtained from microvesicles and a method of applying these gene signatures in helping to determine a biological condition. The determination of a biological condition may aid, for example, the diagnosis, prognosis, and therapy treatment selection for disease in a subject. | 01-07-2016 |
20160000940 | MIRNA PROFILING COMPOSITIONS AND METHODS OF USE - Disclosed herein is a nanosensor of miRNA activity in a target cell, and methods of use, for detection and diagnostic applications. The nanosensor comprises a delivery particle comprising an iron oxide crystal coated with a polymer; and a sensor oligonucleotide covalently attached to the polymer. The sensor oligonucleotide comprises a seed region, comprising a nucleic acid sequence that is completely complementary to the target miRNA and comprises a cleavage site which can be engaged and cleaved by the target miRNA. | 01-07-2016 |
20160000794 | METHODS FOR THE DIAGNOSIS AND TREATMENT OF SJOGREN'S SYNDROME - The finding that patients with Sjögren's syndrome exhibit a statistically significant increase in expression of BMP6 in the salivary gland, relative to healthy control subjects, is described. Also described is the finding that overexpression of BMP6 in the salivary glands of mice results in an increase in electrical potential across the salivary gland. Methods of diagnosing a subject as having Sjögren's syndrome, or at risk for developing Sjögren's syndrome, by measuring the level of BMP6 expression in a salivary gland of a subject, measuring electrical potential in a salivary gland of a subject, or both, are described. Methods of treating a subject with Sjögren's syndrome, or methods of increasing salivary flow in a subject, by administering an agent that inhibits BMP6 expression or activity are also described. The use of XIST and MECP2 as diagnostic and therapeutic targets for male Sjögren's syndrome patients is further described. | 01-07-2016 |
20150366651 | BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME - The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits. | 12-24-2015 |
20150362491 | METHODS AND ASSAYS RELATING TO RNF216 - The technology described herein relates to the diagnosis and treatment of Gordon Holmes Syndrome and cortical degradation. | 12-17-2015 |
20150328189 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE - Provided herein are compounds according to formula (I): provided herein is also a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and a method for providing anesthesia in a subject by administering such a pharmaceutical composition. | 11-19-2015 |
20150322532 | USE OF MICROVESICLES IN ANALYZING MUTATIONS - Microvesicles are small membrane vesicles that either shed or bud off eukarotic cells. Analysis of the nucleic acid content of microvesicles may be useful in detecting the presence or absence of genetic aberrations. This invention discloses novel methods of diagnosing, prognosing, monitoring, or treating a disease, such as cancer, or other medical condition in a subject involving analyzing one or more nucleic acids contained within an isolated microvesicle for the presence or absence of one or more Kras genetic aberrations. | 11-12-2015 |
20150322404 | ISOLATED ADULT CELLS, ARTIFICIAL ORGANS, REHABILITATED ORGANS, RESEARCH TOOLS, ORGAN ENCASEMENTS, ORGAN PERFUSION SYSTEMS, AND METHODS FOR PREPARING AND UTILIZING THE SAME - One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ. | 11-12-2015 |
20150314038 | High Temperature Melting - The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided. | 11-05-2015 |
20150307939 | ISOLATION OF PROTEIN FACTORS THAT ASSOCIATE DIRECTLY OR INDIRECTLY WITH NUCLEIC ACIDS - Methods for isolating polypeptides and polypeptide complexes that are associated with a target nucleic acid sequence are provided. The methods comprise the steps of obtaining a sample that comprises a target nucleic acid sequence and one or more polypeptides associated with that target nucleic acid sequence; contacting the sample with at least one oligonucleotide probe that comprises a sequence that is complimentary to and capable of hybridising with at least a portion of the target nucleic acid sequence, wherein the oligonucleotide probe comprises at least one locked nucleic acid (LNA) nucleotide and wherein the oligonucleotide probe further comprises at least one affinity label; allowing the at least one oligonucleotide probe and the target nucleic acid sequence to hybridise with each other so as to form a probe-target hybrid; isolating the probe-target hybrid from the sample by immobilizing the probe-target hybrid through a molecule that binds to the at least one affinity label; and eluting the one or more polypeptides that are associated with the target nucleic acid sequence. Probes for use in the methods of screening are also provided. | 10-29-2015 |
20150306216 | COMBINATIONS OF A PI3K/AKT INHIBITOR COMPOUND WITH AN HER3/EGFR INHIBITOR COMPOUND AND USE THEREOF IN THE TREATMENT OF A HYPERPROLIFERATIVE DISORDER - The invention provides combinations comprising GDC-0068 or GDC-0941, or a pharmaceutically acceptable salt thereof and ME-HD7945A. The combinations are particularly useful for treating hyperproliferative disorders, such as cancer (e.g., triple negative breast cancer). | 10-29-2015 |
20150306120 | INHIBITING INFLAMMATION WITH MILK OLIGOSACCHARIDES - A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides. | 10-29-2015 |
20150293127 | ARGININE VASOPRESSIN PRO-HORMONE AS PREDICTIVE BIOMARKER FOR DIABETES - Subject of the present invention are assays and in vitro methods for the prediction of the risk of a subject for contracting metabolic syndrome and/or diabetes mellitus and for diagnosing metabolic syndrome, comprising determining the level of arginine vasopres sin pro-hormone or fragments thereof in a sample of a subject. | 10-15-2015 |
20150272442 | APPARATUS AND METHOD FOR PROVIDING DIFFUSE SPECTROSCOPY CO-REGISTERED WITH OPTICAL FREQUENCEY DOMAIN IMAGING - An apparatus can be provided according to certain exemplary embodiments. For example, the apparatus can include a waveguiding first arrangement providing at least one electromagnetic radiation. A configuration can be provided that receives and splits the at least one electromagnetic radiation into a first radiation and a second radiation. The apparatus can further include a waveguiding second arrangement which has a first waveguide and a second waveguide, whereas the first waveguide receives the first radiation, and the second waveguide receives the second radiation. The first arrangement, the second arrangement and the configuration can be housed in a probe. | 10-01-2015 |
20150253240 | METHODS, SYSTEMS, ARRANGEMENTS AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING MICRO-OPTICAL COHERENCE TOMOGRAPHY PROCEDURES - Exemplary apparatus and method can be provided for obtaining data regarding a plurality of samples. For example, using at least one arrangement, it is possible to receive interferometric information that is based on radiations provided from a reference and the samples that are provided in respective chambers. Alternatively and/or in addition, based on the interferometric information, it is possible to discriminate between agents to identify a particular agent that affects a particular function within at least one of the samples. | 09-10-2015 |
20150252061 | BODIPY DYES FOR BIOLOGICAL IMAGING - This invention relates to water-soluble mono-alkoxy and mono-alkyne BODIPY derivatives, including methods for a making the same. For examples, provided herein are compounds of Formula (I): (I) or a pharmaceutically acceptable salt thereof wherein: (a) is a BOD1PY ligand system; X is a halogen; L is absent or a linker; and Z is selected from the group consisting of: a group reactive with a biologically active molecule and a detectable agent. | 09-10-2015 |
20150246893 | FUNCTIONALIZED 1,2,4,5-TETRAZINE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS - The present application relates to functionalized 1,2,4,5-tetrazine compounds. The compounds are useful in compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reactions for the rapid and specific covalent delivery of a “payload” to a ligand bound to a biological target. | 09-03-2015 |
20150246134 | Biotin Complexes for Treatment and Diagnosis of Alzheimer's Disease - Described herein are compositions and methods for treating or imaging Alzheimer's disease (AD). The compositions comprise a biotin moiety and a siRNA moiety, without the need for a targeting agent such as an antibody, avidin, or streptavidin. In certain embodiments, the compositions further comprise a diagnostic agent. | 09-03-2015 |
20150245596 | MELANOCORTIN RECEPTOR MUTANT MOUSE AND USES THEREOF - Embodiments disclosed are transgenic mice having mutations in a MC1R and a BRAF gene. Such transgenic mice have high incidences of invasive melanomas. These transgenic mice are useful animal systems and tools for screening test candidates for the treatment of melanoma involving MC1R and BRAF mutations. | 09-03-2015 |
20150238214 | Method and Apparatus for Tissue Grafting and Copying - Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue. | 08-27-2015 |
20150238084 | SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM WHICH PROVIDE MICROSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION - Exemplary embodiments of apparatus, systems and methods can be provided for providing at least one electro-magnetic radiation to at least one sample. For example, a plurality of wave-guiding arrangements can be provided which are configured to (i) provide the electro-magnetic radiation(s), and (ii) at a point of emission of each of the wave guiding arrangements, cause a phase of each of the electro-magnetic radiation(s) to have a predetermined value. The exemplary apparatus can be part of a probe. Further the exemplary apparatus can include an interferometric arrangement provided in communication with the probe and/or be part of the probe. | 08-27-2015 |
20150232836 | COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION - Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of a target gene. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of a target gene. Methods for modulating expression of a target gene using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of a target gene. | 08-20-2015 |
20150225800 | METHODS AND ASSAYS FOR TREATMENT OF BLADDER CANCER - The technology described herein relates to methods of prognosing and treating bladder cancer. | 08-13-2015 |
20150223975 | METHOD AND APPARATUS FOR AFFECTING PIGMENTATION OF TISSUE - Exemplary apparatus and method can be provided for cooling a skin tissue. For example, it is possible to use a contact arrangement comprising a distal surface to contact a surface of the skin tissue, and also to utilize a cooling arrangement. The cooling arrangement can be configured to cool at least one portion of the contact arrangement to a temperature that is less than about −4 degrees Celsius. The distal surface of the contact arrangement can comprise a plurality of dimples provided therein. | 08-13-2015 |
20150223698 | APPARATUS, SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM FOR ANALYZING INFORMATION REGARDING CARDIOVASCULAR DISEASES AND FUNCTIONS - According to an exemplary embodiment of the present disclosure, apparatus and method can be provided for determining information regarding a tissue or an object at or within the tissue. For example, with at least one first arrangement which is situated inside a particular organ of the body, it is possible to generate at least one electromagnetic radiation in the tissue, wherein the tissue is different from and outside of the particular organ. The particular signals that are responsive to the at least one electromagnetic radiation can be detected (e.g., possibly with at least one second arrangement), at least one characteristic of the tissue and/or information regarding the object at or in the tissue can be determined (e.g., with the second arrangement(s)). Alternatively or in addition, the tissue can be different from and outside of the particular organ, and the first arrangement(s) can be situated inside a particular organ of the body. To that end, the can include (i) the heart, (ii) major vessels attached to the heart, (iii) coronary artery, and/or (iv) blood therein. | 08-13-2015 |
20150218282 | COMPOSITIONS AND METHODS FOR TREATING CANCER - The technology described herein is directed to methods and compositions directed to the treatment of cancer, e.g. using multifunctional receptor targeted cancer therapeutics. | 08-06-2015 |
20150210920 | APPARATUS, METHOD AND SYSTEM FOR GENERATING OPTICAL RADIATION FROM BIOLOGICAL GAIN MEDIA - In one exemplary embodiment, an apparatus can be provided which includes at least one biological medium that causes gain. According to another exemplary embodiment, an arrangement can be provided which is configured to be provided in an anatomical structure. This exemplary arrangement can include at least one emitter having a cross-sectional area of at most 10 microns within the anatomical structure, and which is configured to generate at least one laser radiation. In a further exemplary embodiment, an apparatus can be provided which can include at least one medium which is configured to cause gain; and at least one optical biological resonator which is configured to provide an optical feedback to the medium. In still another exemplary embodiment, a process can be whereas, a solution of an optical medium can be applied to a substrate. Further, it is possible to generate a wave guide having a shape that is defined by (i) at least one property of the solution of the optical medium, or (ii) drying properties thereof. | 07-30-2015 |
20150190545 | SPATIAL CONTROL OF ADDITIVES BY HIGH TEMPERATURE - Provided is a method of making a polymeric material with a spatially controlled distribution of one or more additives including the steps of blending the one or more additives with a polymeric material, consolidating the polymeric material, heating at least a portion of at least one surface of the consolidated additive-blended polymeric material, and cooling the heated consolidated additive-blended polymeric material, thereby forming a polymeric material with a spatially controlled distribution of additive. | 07-09-2015 |
20150177353 | Method for Magnetic Resonance Imaging with Controlled Aliasing - A method for imaging a subject with a magnetic resonance imaging (MRI) system using controlled aliasing is provided. A radio frequency (RF) excitation field is applied to excite the spins in a volume-of-interest that may include multiple slice locations. Using the MRI system, a readout magnetic field gradient is established following the application of the RF excitation field to form echo signals. These echo signal receive a differential encoding by way of establishing, while the readout gradient is established, alternating magnetic field gradients along two directions, such as the partition-encoding and phase-encoding directions. Image data is acquired from the formed echo signals and images of the subject are reconstructed from the acquired image data. | 06-25-2015 |
20150158841 | Curcumin Analogs - Provided herein are curcumin analogues that are able to interact with amyloid β (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds in the treatment of Alzheimer's Disease or a related disorder. | 06-11-2015 |
20150140013 | MODULATION OF ASYMMETRIC PROLIFERATION - Provided herein are methods and compositions related to modulation of the rate of asymmetric proliferation of cancer cells. In some embodiments, the methods described herein relate to the treatment of cancer, at least in part, via the modulation of the rate of asymmetric proliferation of cancer cells. | 05-21-2015 |
20150111902 | Methods for Altering MRNA Splicing and Treating Familial Dysautonomia by Administering Kinetin, Benzyladenine, and Tocotrienols - This invention relates to methods for altering the splicing of mRNA in cells. In particular, this invention also relates to methods for increasing the ratio of wild type to misspliced forms of mRNA and corresponding encoded proteins in cells possessing a mutant gene encoding either the i) misspliced mRNA corresponding to the mutant protein or ii) a component in the splicing machinery responsible for processing the misspliced mRNA. In addition, this invention relates to treating individuals having a disorder associated with a misspliced mRNA, such as Familial Dysautonomia or Neurofibromatosis 1, by administering to such an individual a cytokinin such as kinetin. | 04-23-2015 |
20150111276 | BLOOD CELL SORTING METHODS AND SYSTEMS - The invention relates to methods of isolating white blood cells (WBCs) from a sample, e.g., whole blood, using magnetic particles that specifically bind to WBCs and a series of specific steps and conditions. The methods can include one or more of decreasing the viscosity of the sample prior to WBC isolation, agitating the sample at specified frequencies, and/or using a sample container arranged such that all of the sample is placed in close proximity (e.g., within 5, 2, 1, or 0.5 mm) to the source of the magnetic field. The new methods provide for isolation of WBC preparations with high yield, purity, and viability. The methods are designed for compatibility with automation protocols for rapid processing of multiple samples. | 04-23-2015 |
20150088264 | Implant for Restoring Normal Range Flexion and Kinematics of the Knee - Embodiments of the invention provide knee prostheses which more faithfully and closely replicate the function, anatomy and physiology of the normal human knee yielding a number of advantages. Among other things, such prostheses can provide an increased range of motion and function more normally particularly in extension, deep flexion and during normal gait. Knee prostheses according to various aspects of the invention recognize that during movement of the knee, particularly during flexion, the kinematics of the bones of the knee are a result of achieving equilibrium of the forces that cause motion of the knee. In addition, the shape of the articular surfaces acting in combination with forces imposed by various muscles, ligaments and tendons, determines the direction of the large contact forces. | 03-26-2015 |
20150080738 | APPARATUS, METHOD, AND COMPUTER-ACCESSIBLE MEDIUM FOR DETERMINING ANTIGEN IMMUNOREACTIVITY IN TISSUE - Exemplary configurations can be provided which can be structured to be included and/or inserted in an internal anatomical structure. For example, the configuration(s) can have at least one first arrangement which can include at least one substance that, when applied to at least one section of the internal anatomical structure, has a potential to induce an inflammatory response in the section(s). The configuration(s) can also have at least one second (e.g., microscopy) arrangement which can be configured to receive information from the section(s), and determine whether the inflammatory response has occurred therein. | 03-19-2015 |
20150079631 | MICROVESICLE-MEDIATED DELIVERY OF THERAPEUTIC MOLECULES - Disclosed herein are methods to produce extracellular vesicles such as microvesicles that contain therapeutic molecules. Such therapeutic molecules can be nucleic acid or protein or combinations thereof. Methods to deliver the therapeutic molecules to a cell are also disclosed. Therapeutic methods of treatment of disease such as cancer by delivering conditionally a lethal molecule to the cancer cells by administering microvesicles are also disclosed. | 03-19-2015 |
20150079107 | AGENTS AND METHODS FOR TREATING AND PREVENTING SEBORRHEIC KERATOSIS - Provided herein are methods and assays for isolating and culturing seborrheic keratosis cells ex vivo. Also provided herein are screening assays using cultured seborrheic keratosis cells and methods for treating seborrheic keratosis in a subject. | 03-19-2015 |
20150079055 | USE OF SECRETOR, LEWIS AND SIALYL ANTIGEN LEVELS IN CLINICAL SAMPLES AS PREDICTORS OF RISK FOR DISEASE - An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewis | 03-19-2015 |
20150077755 | METHOD AND APPARATUS FOR PERFORMING OPTICAL IMAGING USING FREQUENCY-DOMAIN INTERFEROMETRY - An apparatus and method are provided. In particular, at least one first electro-magnetic radiation may be provided to a sample and at least one second electro-magnetic radiation can be provided to a non-reflective reference. A frequency of the first and/or second radiations varies over time. An interference is detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. Alternatively, the first electro-magnetic radiation and/or second electro-magnetic radiation have a spectrum which changes over time. The spectrum may contain multiple frequencies at a particular time. In addition, it is possible to detect the interference signal between the third radiation and the fourth radiation in a first polarization state. Further, it may be preferable to detect a further interference signal between the third and fourth radiations in a second polarization state which is different from the first polarization state. The first and/or second electro-magnetic radiations may have a spectrum whose mean frequency changes substantially continuously over time at a tuning speed that is greater than 100 Tera Hertz per millisecond. | 03-19-2015 |
20150065795 | Optical Coupler for an Endoscope - An optical coupler is disclosed for mounting at a distal end of an optical imaging device for visualizing a surface area covered with an opaque fluid and/or particulate matter. The coupler includes a visualization section at one end of the coupler and an attachment section connected to and extending away from the visualization section. The attachment section is dimensioned to be mounted at the distal end of the optical imaging device. The visualization section includes a proximal surface for engaging the distal end of the optical imaging device. The visualization section includes an outer surface spaced apart from the proximal surface. The outer surface extends continuously from a first outer side boundary across to a second opposite outer side boundary of the visualization section. The visualization section may include a hollow instrument channel extending from the proximal surface toward the outer surface. | 03-05-2015 |
20150056615 | ISOLATION OF FACTORS THAT ASSOCIATE DIRECTLY OR INDIRECTLY WITH NON-CODING RNAS - Methods and assays are provided for isolating factors including polypeptides, ribonucleic acids (RNAs) and polypeptide complexes that are associated with a target nucleic acid sequence. The target nucleic acid sequence may be comprised within chromatin. The methods are suitable for identification and characterisation of factors including non-coding RNAs (ncRNAs) that associate with specified genomic loci. | 02-26-2015 |
20150049339 | METHOD AND APPARATUS FOR OPTICAL IMAGING VIA SPECTRAL ENCODING - Exemplary method, apparatus and arrangement can be provided for obtaining information associated with a sample such as a portion of an anatomical structure. The information can be generated using first data, which can be based on a signal obtained from a location on the sample, and second data, where the second data can be obtained by combining a second signal received from the sample with a third reference signal. An image of a portion of the sample can also be generated based on the information. For example, the first data can be associated with spectral encoding microscopy data, and the second data can be associated with optical coherence tomography data. | 02-19-2015 |
20150045622 | SPECTRALLY-ENCODED ENDOSCOPY TECHNIQUES, APPARATUS AND METHODS - Exemplary apparatus for obtaining information for a structure can be provided. For example, the exemplary apparatus can include at least one first optical fiber arrangement which is configured to transceive at least one first electro-magnetic radiation, and can include at least one fiber. The exemplary apparatus can also include at least one second focusing arrangement in optical communication with the optical fiber arrangement. The second arrangement can be configured to focus and provide there through the first electro-magnetic radiation to generate the focused electro-magnetic radiation. Further, the exemplary apparatus can include at least at least one dispersive third arrangement which can receive a particular radiation (e.g., the first electro-magnetic radiation(s) and/or the focused electro-magnetic radiation), and forward a dispersed radiation thereof to at least one section of the structure. | 02-12-2015 |
20150031863 | CONJUGATING AMINES - The disclosure provides directly conjugated polysaccharide vaccine molecules and methods related thereto. | 01-29-2015 |
20150030611 | Monitoring and Modulating HGF/HGFR Activity - Provided are methods and compositions for the modulation of hepatocyte growth factor activity to regulate lymphatic vessel development and function. Methods and composition for the monitoring and treatment of skin disorders, lymphedema, and metastatic cancers are disclosed. Also described are methods of identifying inhibitors of hepatocyte growth factor dependent lymphangiogenesis. | 01-29-2015 |
20150029513 | SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM WHICH PROVIDE MICROSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION - Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from the portion which is based on the first radiation. Based on an interaction between the optical arrangement and the first radiation and/or the second radiation, the optical arrangement can have a first transfer function. Further, it is possible to forward at least one third radiation to the portion through such optical arrangement (or through another optical arrangement), and receive at least one fourth radiation from the portion which is based on the third radiation. Based on an interaction between the optical arrangement (or the other optical arrangement) and the third radiation and/or the fourth radiation, the optical arrangement (or the other optical arrangement) can have a second transfer function. The first transfer function can be at least partially different from the second transfer function. The data can be generated based on the second and fourth radiations. | 01-29-2015 |
20150024036 | TARGETING RNAS TO MICROVESICLES - Disclosed herein is an isolated nucleic acid molecule comprising a first nucleic acid sequence 5′-ACCCTGCCGCCTGGACTCCGCCTGT-3′ (SEQ ID NO: 22), or a functional variant thereof, operably linked to a second, heterologous nucleic acid sequence. The isolated nucleic acid molecule can be DNA (in an expression vector) and RNA (mRNA, shRNA, orncRNA). Also disclosed is a microvesicle comprising the nucleic acid molecule and a microvesicle preparation comprising the microvesicle. Also disclosed is an in vitro method of producing a microvesicle preparation enriched for a specific RNA sequence by transfecting cells with the nucleic acid sequence, and isolating microvesicles generated therefrom. Methods of delivering therapeutic RNA to a subject are also disclosed. | 01-22-2015 |
20150023868 | HIF INHIBITORS AND USE THEREOF - The present invention is directed to HIF inhibitors and methods of preventing cell proliferation, reducing inflammation, and treating an angiogenic disease or disorders. | 01-22-2015 |
20150011603 | ETOMIDATE ANALOGUES THAT DO NOT INHIBIT ADRENOCORTICAL STEROID SYNTHESIS - The invention is directed to compounds according to formula (I): where R | 01-08-2015 |
20140378845 | APPARATUS, DEVICES AND METHODS FOR OBTAINING OMNIDIRECTIONAL VIEWING BY A CATHETER - An apparatus for obtaining information regarding a biological structure(s) can include, for example a light guiding arrangement which can include a fiber through which an electromagnetic radiation(s) can be propagated, where the electromagnetic radiation can be provided to or from the structure. An at least partially reflective arrangement can have multiple surfaces, where the reflecting arrangement can be situated with respect to the optical arrangement such that the surfaces thereof each can receive a(s) beam of the electromagnetic radiations instantaneously, and a receiving arrangement(s) which can be configured to receive the reflected radiation from the surfaces which include speckle patterns. | 12-25-2014 |
20140378385 | Histone Deacetylase 6 Selective Inhibitors for the Treatment of Bone Disease - This invention relates to methods for treating bone disease associated with osteoclast activation using HDAC6 selective inhibitors, e.g., small molecule inhibitors such as reverse amide compounds. | 12-25-2014 |
20140371165 | Identification of NSC23925 Isomers to Reverse Multidrug Resistance in Human Cancers - This disclosure features optically active stereoisomers of (2-(4-methoxy)quinolin-4-yl)(piperidin-2-yl)methanol that reduce drug resistance, compositions containing the same, and methods of using and preparing the same. | 12-18-2014 |
20140358133 | METHOD AND APPARATUS FOR SKIN STABILIZATION AND POSITIONING - Exemplary embodiments of a method, device, and apparatus for positioning an apparatus on a location of a tissue. For example, a substantially rigid film over an area of tissue to be treated can be provided. The film can include a positioning arrangement that facilitates a particular spatial engagement with the apparatus. The exemplary method can further include applying a portion of the film to a portion of a surface of the tissue and positioning the apparatus at the location by the engagement of the film to the apparatus using the feature of the film. | 12-04-2014 |
20140358069 | METHOD AND APPARATUS FOR DERMATOLOGICAL TREATMENT AND TISSUE RESHAPING - The present invention provides improved methods and apparatus for skin treatment and tissue remodeling. The apparatus includes an array of needles that penetrate the skin and serve as electrodes to deliver radio frequency current or other electrical or optical energy into the tissue being treated, causing thermal damage in controlled patterns. The damaged regions promote beneficial results such as uniform skin tightening by stimulation of wound healing and collagen growth. | 12-04-2014 |
20140336178 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES - The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another. | 11-13-2014 |
20140336066 | DRG11-RESPONSIVE (DRAGON) GENE AND USES THEREOF - This invention features methods and compositions useful for treating and diseases caused by a dysregulation of the BMP/GDF branch of the TGF-β signaling pathway. Also disclosed are methods for identifying compounds useful for such therapy. | 11-13-2014 |
20140335611 | COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS - Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described. | 11-13-2014 |
20140335050 | METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF CANCER - The invention features methods, compositions, and kits for the administration of an HSP90 inhibitor, OBAA, flunarizine, aphidicolin, damnacanthal, dantrolene, or an analog thereof, alone, or in combination with, e.g., a TAA, an antigen-binding scaffold (e.g., an antibody, a soluble T cell receptor, or a chimeric receptor) specific for a TAA, a cell (e.g., a white blood cell that targets a cancer cell), and/or an IFN-β receptor agonist or an IFN-γ receptor agonist, for the treatment of cancer. | 11-13-2014 |
20140330195 | COMPOSITIONS AND METHODS FOR CONTROLLING NEURONAL EXCITATION - Embodiments of the technology described herein relate, at least in part, to methods of modulating the activity of a neuron by contacting the neuron with a photo-sensitive TrpA1 agonist and then illuminating the neuron with electromagnetic radiation. Also described herein are photo-sensitive TrpA1 agonists. | 11-06-2014 |
20140309288 | GENE THERAPY INDUCED PYROPTOSIS FOR THE TREATMENT OF TUMORS - Described herein are compositions and methods for treating, inhibiting, preventing, reducing the severity of and/or reducing the progression of schwannoma, as well as any disease or physiological disease-state in which schwannoma plays a role. The compositions comprise an rAAV vector that includes a caspase-1 gene or a variant thereof and a Schwann cell specific promoter. | 10-16-2014 |
20140309125 | MARKERS RELATED TO AGE-RELATED MACULAR DEGENERATION AND USES THEREFOR - Described herein are compositions, kits and methods for diagnosing and tracking the progression of AMD in a subject by detecting the presence or absence of particular lipid metabolism markers associated with AMD. Predictive computer models of disease risk are also disclosed. | 10-16-2014 |
20140308336 | LOCAL DRUG DELIVERY DEVICES AND METHODS FOR TREATING CANCER - Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 μm to about 1000 μm, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site. | 10-16-2014 |
20140307752 | APPARATUS AND METHOD WHICH CAN INCLUDE CENTER-WAVELENGTH SELECTABLE, BANDWIDTH ADJUSTABLE, SPECTRUM CUSTOMIZABLE, AND/OR MULTIPLEXABLE SWEPT-SOURCE LASER ARRANGEMENT - Systems, methods and computer-accessible mediums for providing a radiation(s) can be provided. For example, a hardware arrangement can be configured to provide the radiation(s) that can have a wavelength(s) that continuously changes over time and over a predetermined bandwidth with a predetermined envelope in a single sweep. The hardware arrangement can include a gain arrangement and a controller arrangement, and the controller arrangement can be configured to electronically control the gain arrangement such that the wavelength(s) provided by the hardware arrangement (i) spans a subset of the predetermined bandwidth, or (ii) changes a wavelength dependent distribution in the single sweep. | 10-16-2014 |
20140303697 | METHOD AND APPARATUS FOR CRYOGENIC TREATMENT OF SKIN TISSUE - Cosmetic method and apparatus are provided that can provide cooling and/or freezing of skin tissue proximal to the skin surface to generate an appearance of lightening or reduced pigmentation in the skin. The skin can be cooled to a temperature of less than about −5 degrees Celsius for a duration of about one minute or less, using a plurality of cooled contact surfaces, each having a width between about 2 mm and about 20 mm. A cooling arrangement can be provided to provide controlled heat removal from the skin tissue being treated. A sensor can optionally be provided to detect freezing of tissue proximal to the cooled surfaces. | 10-09-2014 |
20140303696 | METHOD AND APPARATUS FOR CRYOGENIC TREATMENT OF SKIN TISSUE - Cosmetic method and apparatus are provided that can provide cooling and/or freezing of skin tissue proximal to the skin surface to generate an appearance of lightening or reduced pigmentation in the skin. The skin can be cooled to a temperature of less than about −5 degrees Celsius for a duration of about one minute or less, using a cooled surface that is at least 3 cm in width. A cooling arrangement can be provided to provide controlled heat removal from the skin tissue being treated. A sensor can optionally be provided to detect freezing of tissue proximal to the cooled surface. | 10-09-2014 |
20140303458 | SYSTEMS AND METHODS FOR INHIBITING APNEIC EVENTS - Systems and methods are disclosed to monitor physiological for the occurrence of life threatening events and to apply stimulation to prevent the occurrence of said life-threatening events. Systems and methods for applying the stimulation are also disclosed. These systems include applying the stimulation through via a mattress having a passive section and an active section, a plurality of focal stimulators, and/or an array to apply the stimulation are also disclosed. These devices include a mattress with an active region and a passive region, a stimulating array do deliver targeted stimulation, and a plurality of stimulators to apply focused stimulation. | 10-09-2014 |
20140303022 | Magnetic-nanoparticle conjugates and methods of use - The present invention provides novel compositions of binding moiety-nanoparticle conjugates, aggregates of these conjugates, and novel methods of using these conjugates, and aggregates. The nanoparticles in these conjugates can be magnetic metal oxides, either monodisperse or polydisperse. Binding moieties can be, e.g., oligonucleotides, polypeptides, or polysaccharides. Oligonucleotide sequences are linked to either non-polymer surface functionalized metal oxides or with functionalized polymers associated with the metal oxides. The novel compositions can be used in assays for detecting target molecules, such as nucleic acids and proteins, in vitro or as magnetic resonance (MR) contrast agents to detect target molecules in living organisms. | 10-09-2014 |
20140302480 | COMPOSITE TISSUE GRAFT AND MATERIALS AND METHODS FOR ITS PRODUCTION AND USE - The technology described herein is directed to tissue engineering, e.g. to biomimetic compositions as well as methods and devices related to producing a biomimetic composition. | 10-09-2014 |
20140302025 | VEGF-BINDING PROTEIN FOR BLOCKADE OF ANGIOGENESIS - Provided are chimeric VEGF-binding proteins and nucleic acids (e.g., a vector) encoding chimeric VEGF-binding proteins, methods and host cells for producing these proteins and nucleic acids, and pharmaceutical compositions containing these proteins and nucleic acids. Also provided are methods of treating an angiogenic disease or disorder that include administering at least one of the chimeric VEGF-binding proteins or at least one of the nucleic acids (e.g., a vector) encoding a chimeric VEGF-bind ing protein. | 10-09-2014 |
20140301620 | METHODS AND SYSTEMS FOR OPTICAL IMAGING OR EPITHELIAL LUMINAL ORGANS BY BEAM SCANNING THEREOF - Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample. | 10-09-2014 |
20140296741 | METHOD AND APPARATUS FOR SUBSURFACE TISSUE SAMPLING - Exemplary embodiments of method and apparatus are provided for removing a subsurface sample of a biological tissue while leaving the overlying tissue substantially undamaged. A hollow needle can be provided that includes an opening in the wall and a protruding cutting edge adjacent to the opening. A sliding sleeve can be provided over a portion of the needle. The needle and sleeve can be advanced into the tissue such that the cutting edge is deeper than the distal end of the sleeve. The needle may then be withdrawn while holding the sleeve stationary, such that a sample is severed by the cutting edge and directed into the hollow needle through the opening, until the cutting edge reaches the end of the sleeve. The sleeve and needle containing the sample can then be withdrawn from the tissue together. | 10-02-2014 |
20140296223 | METHOD FOR REGULATING SKIN PIGMENTATION - This invention relates to a method for regulating skin pigmentation of a subject, comprising the step of administering the agent for inhibiting the expression or activation of Microphthalmia Transcription Factor (MITF) to the subject who is in need of regulation of skin pigmentation. | 10-02-2014 |
20140296141 | Compositions and Methods for Treating Obesity, Obesity Related Disorders and for Inhibiting the Infectivity of Human Immunodeficiency Virus - The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues. | 10-02-2014 |
20140295557 | Using Truncated Guide RNAs (tru-gRNAs) to Increase Specificity for RNA-Guided Genome Editing - Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs). | 10-02-2014 |
20140295556 | Using RNA-guided FokI Nucleases (RFNs) to Increase Specificity for RNA-Guided Genome Editing - Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems. | 10-02-2014 |
20140295460 | Analyte Detection Using Magnetic Hall Effect - Determining a presence of a target analyte in a fluid sample includes mixing multiple magnetic particles with the fluid sample, in which the magnetic particles are each bound to one or more binding moieties that specifically bind to the target analyte, flowing the fluid sample containing the magnetic particles through a fluidic channel, exposing the fluid sample in the fluidic channel to a magnetic field, measuring a signal from a Hall effect sensor while the fluid sample flows through the fluidic channel, and determining whether the target analyte is present in the fluid sample when the measured signal is in a first range of values. | 10-02-2014 |
20140288569 | NON-LITHOTRIPSIC KIDNEY-STONE THERAPY - One aspect of the present invention relates to a method of using peristalsis to force a polymer plug through a mammalian lumen, thereby removing any calculi and/or calculi fragments present in the lumen. In one embodiment, the method is used as an alternative to conventional lithotripsy. In another embodiment, the method is used in conjunction with lithotripsy, thereby removing the small calculi fragments that result from such procedures. | 09-25-2014 |
20140288093 | TREATMENT OF PROTEINOPATHIES - The present disclosure provides technologies relating to lysosomal activation. The disclosure provides several strategies for increasing level and/or activity of lysosomal enzyme, and furthermore demonstrates the surprising applicability of such strategies in the treatment and/or prophylaxis of certain proteinopathies. Among other things, the present invention provides methods and compositions for the treatment and/or prophylaxis of proteinopathies other than lysosomal storage diseases through lysosomal activation. In particular, the present disclosure provides methods and compositions for the treatment and/or prophylaxis of neurodegenerative proteinopathies, and in particular those associated with accumulation of α-synuclein. The present disclosure specifically provides methods and compositions for the treatment and/or prophylaxis of Parkinson's disease. | 09-25-2014 |
20140285810 | APPARATUS AND METHOD FOR FACILITATING MESOSCOPIC SPECTRALLY ENCODED TOMOGRAPHY CO-REGISTERED WITH OPTICAL FREQUENCY DOMAIN IMAGING AND/OR SPECTRALLY ENCODED CONFOCAL MICROSCOPY - An apparatus for illuminating a sample(s) can be provided. For example, a first arrangement can transmit a first electro-magnetic radiation and a second electro-magnetic radiation; the first and second electro-magnetic radiations can have different wavelengths from one another. The first arrangement can transmit the first and second electro-magnetic radiations to different spatial locations on the sample(s). A second arrangement(s) can be configured to receive a third radiation(s) provided from the sample(s), the third radiation(s) can be associated with an interaction of the first and second electro-magnetic radiations in the sample(s). A processing third arrangement can be configured to receive, from the second arrangement, at least one fourth radiation that can be based on the third radiation(s), and generate information regarding a sub-surface portion(s) of the sample(s) based on the fourth radiation. | 09-25-2014 |
20140277055 | METHOD AND APPARATUS FOR DAMAGE AND REMOVAL OF FAT - Exemplary embodiments of method and apparatus are provided for damaging and/or removing portions of subcutaneous fatty tissue while leaving the overlying dermal layer of the skin substantially undamaged. One or more hollow needles can be provided that include an arrangement within the lumen configured to retain or damage portions of fatty tissue that enter the lumen. Properties of the needle can be selected such that the needle can be inserted into skin and pass through the dermal layer, allowing fatty tissue to enter the distal portion of the lumen as it is advanced further, and then leaving the dermis undamaged when withdrawn. Such exemplary apparatus can include a plurality of such needles, a reciprocating arrangement to mechanically advance and withdraw the one or more needles, and/or a vibrating arrangement. | 09-18-2014 |
20140276358 | LASER ADJUVANTS FOR ENHANCING IMMUNE RESPONSE - Methods for enhancing an immune response to a vaccine using co-administration of radiation. | 09-18-2014 |
20140275318 | METHODS FOR MAKING OXIDATION RESISTANT POLYMERIC MATERIAL - The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein. | 09-18-2014 |
20140274812 | Methods of Transcription Activator Like Effector Assembly - The disclosure describes methods that include providing a first nucleic acid having a sequence encoding a first set comprising one or more transcription activator-like effector (TALE) repeat domains and/or one or more portions of one or more TALE repeat domains; contacting the first nucleic acid with a first enzyme, wherein the first enzyme creates a first ligatable end; providing a second nucleic acid having a sequence encoding a second set comprising one or more TALE repeat domains and/or one or more portions of one or more TALE repeat domains; contacting the second nucleic acid with a second enzyme, wherein the second enzyme creates a second ligatable end, and wherein the first and second ligatable ends are compatible; and ligating the first and second nucleic acids through the first and second ligatable ends to produce a first ligated nucleic acid, wherein the first ligated nucleic acid is linked to a solid support, and wherein the first ligated nucleic acid encodes a polypeptide comprising said first and second sets. | 09-18-2014 |
20140272383 | HIGHLY CRYSTALLINE POLYETHYLENE - The present invention relates to methods for making highly crystalline polymeric material, for example, highly crystalline cross-linked and not cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making additive-doped highly crystalline polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein. | 09-18-2014 |
20140261212 | NOVEL GERM CELL ABLATION COMPOUNDS AND USES THEREOF - Provided herein are methods of sterilizing fish by contacting an embryonic or juvenile fish with a compound of formula (I). In some embodiments, the compound is primordazine or a derivative thereof. | 09-18-2014 |
20140255426 | WNT PATHWAY INHIBITORS FOR TREATING VIRAL INFECTIONS - In certain embodiments, the disclosure relates to methods of treating or preventing a viral infection comprising administering an effective amount of a Wnt pathway inhibitor optionally in combination with one or more anti-viral agents. In certain embodiments, the subject is diagnosed with a chronic viral infection such as human immunodeficiency virus (HIV). | 09-11-2014 |
20140249430 | LIFE SIGN DETECTION AND HEALTH STATE ASSESSMENT SYSTEM - A wearable platform embodied in a belt or patch provides physiological monitoring of soldiers during field operations or trauma victims at accident sites and makes health state assessments. The platform includes sensors for heart rate, body motion, respiration rate and intensity, and temperature and further contains a microprocessor and short range transmitter. An analog circuit running an algorithm obtains the R-wave period from the EKG signal and produces electrical pulses with the period between pulses corresponding to the R-wave period. A rule based processing engine having an evaluation algorithm is capable of making a medical evaluation of subject condition and determines a confidence level for the evaluation. The rules are subject to variation depending upon the subject population. The information is communicated wirelessly to a local hub for relay to a remote monitor. | 09-04-2014 |
20140243403 | TREATING COLORECTAL, PANCREATIC, AND LUNG CANCER - The invention relates to methods of determining an appropriate chemotherapy for a subject based on expression levels of a TAK1 biomarker, such as one or more TAK1 biomarkers listed in Table 1, or any subset or combination thereof, e.g., a set of biomarkers consisting of or comprising GGH, BMP7, BAMBI, MBOAT2, HSPA12A, FYN, NAV2, RGL1, SYK and RUNX1 genes, optionally with one or both of INHBB and/or BMPR1A. In some embodiments, the biomarkers include one, two, three, or all of BMP7, BAMBI, BMPR1A, and INHBB. Kits useful for the methods are also provided. | 08-28-2014 |
20140241996 | THERAPEUTIC NANOPARTICLES AND METHODS OF USE THEREOF - Provided herein are therapeutic nanoparticles having a diameter of between 10 nm to 30 nm, and containing a polymer coating, and a nucleic acid containing a sequence complementary to a sequence within a micro-RNA identified as having a role in cancer cell metastasis or anti-apoptotic activity in a cancer cell (e.g., miR-10b) or a sequence within an mRNA encoding a pro-apoptotic protein that is covalently linked to the nanoparticle. Also provided are pharmaceutical compositions containing these therapeutic nanoparticles. Also provided herein are methods of decreasing cancer cell invasion or metastasis in a subject having a cancer and methods of treating a metastatic cancer in a lymph node in a subject that require the administration of these therapeutic nanoparticles to a subject. | 08-28-2014 |
20140234953 | FABRICATION OF VASCULARIZED TISSUE USING MICROFABRICATED TWO-DIMENSIONAL MOLDS - Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided. | 08-21-2014 |
20140234898 | PROTEIN AND PEPTIDE LIBRARIES - Provided herein are, inter alia, methods for linking an mRNA molecule to a polypeptide (e.g., a peptide or a protein) by linking the mRNA molecule to a linking amino acid in the polypeptide, or by linking the mRNA molecule to a linking tRNA to which the polypeptide is attached, via reactions not catalyzed by the ribosome, and methods for making polypeptide libraries. Also provided are mRNA-protein complexes and mRNA-tRNA-protein complexes, libraries containing these complexes, and methods of using these complexes. | 08-21-2014 |
20140221753 | OBJECTIVE LENS ARRANGEMENT FOR CONFOCAL ENDOMICROSCOPY - An apparatus for imaging an anatomical structure(s) can be provided. For example, a housing arrangement can have a shape of a pill and can be to be delivered to the anatomical structure(s). An imaging arrangement can be configured to generate a microscopic image of the anatomical structure(s), wherein the imaging arrangement can include a variable focus lens, and can be provided in the housing arrangement. | 08-07-2014 |
20140221747 | APPARATUS, SYSTEMS AND METHODS WHICH INCLUDE AND/OR UTILIZE FLEXIBLE FORWARD SCANNING CATHETER - These and other objects of the present disclosure can be achieved by provision of an apparatus for illuminating a structure(s), which can include a first arrangement and a second arrangement which can each be configured to rotate and deflect a radiation(s) transmitted therethrough at an angle with respect to an axis of rotation thereof. There can be a plurality of rotating third arrangements, where at least one can be connected to the first arrangement, and at least another one can be connected to the second arrangement. A fourth arrangement can be connected to the third arrangements, and can he configured to rotate the third arrangements. One of the rotating third arrangements can be flexible, can have a length that is greater than ten times a diameter of the first arrangement or the second arrangement, can he surrounded by a housing, and/or can contain an optical waveguide arrangement extending therethrough. | 08-07-2014 |
20140218744 | SYSTEMS, METHOD AND COMPUTER-ACCESSIBLE MEDIUM WHICH UTILIZE SYNTHETIC APERTURE(S) FOR EXTENDING DEPTH-OF-FOCUS OF OPTICAL COHERENCE TOMOGRAPHY IMAGING - An exemplary apparatus can be provided for generating at least one image of a structure. The apparatus can include at least one first arrangement that has a structural configuration with a first aperture and a second aperture. At least one detector second arrangement can b provided which is configured to detect (i) a first electro-magnetic signal provided to or from the structure via the first aperture, and (ii) a second electromagnetic signal provided to or from the structure via the second aperture. The first and second signals can be associated with data regarding at least one portion of the structure. The exemplary apparatus can further include at least one processing third arrangement which is configured to combine an amplitude and a phase of each of the first and second signals with one another to form a combined amplitude and a combined phase of a combined signal, and then generate the image(s) based on the combined signal. | 08-07-2014 |
20140217649 | TISSUE ENGINEERED CONSTRUCTS - The present invention relates to a field of biocompatible membranes, tubes and conduits which comprising a photosensitizer which is capable of being crosslinked to form a three dimensional structure which can be implanted into a subject to assist in tissue bonding and nerve maintenance and development. Methods of making such membranes, tubes and conduits and kits comprising them are also described. | 08-07-2014 |
20140213937 | SYSTEMS AND METHODS TO MONITOR AND QUANTIFY PHYSIOLOGICAL STAGES - Systems and methods detect respiration of a subject, process respiration data, and based on the processed respiration data, perform extended monitoring. A monitoring system is configured with sensors that can be worn by the subject to provide the respiration data. The respiration data is processes to create a stability index. The stability index is used to, for example, determine sleep stages. | 07-31-2014 |
20140213896 | APPARATUS, SYSTEMS AND METHODS FOR PROVIDING INFORMATION REGARDING THE AORTIC VALVE - An apparatus according to an exemplary embodiment of the present disclosure can include a first section(s) and a second section(s) which can have a cross-section that can be smaller than that of the first section. The first and second sections can be a particular section and can include memory-forming characteristics. An imaging arrangement can be in communication with the first section or the second section. The particular section can have a first shape when the particular section can be constrained, and the particular section can have a second shape when the particular section can be unconstrained. The second shape can be more curved than the first shape. | 07-31-2014 |
20140213460 | RNA-YY1 Interactions - Methods relating to obtaining libraries of YY1-binding long non-coding RNAs, libraries obtained thereby, and methods of use thereof. | 07-31-2014 |
20140212472 | Methods of Treatment Using A Pentapeptide Derived From The C-Terminus Of Glucagon-Like Peptide 1 (GLP-1) - Methods of treating obesity, metabolic syndrome, hepatic and non-hepatic steatosis, and diabetes using a pentapeptide, LVKGRamide, derived from the C-terminus of Glucagon-Like Peptide 1 (GLP-1). | 07-31-2014 |
20140206989 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR TRACKING VESSEL MOTION DURING THREE-DIMENSIONAL CORONARY ARTERY MICROSCOPY - Exemplary embodiments of apparatus, method and computer accessible medium can be provided which can facilitate a determination of at least one characteristic of a structure. For example, it is possible to use at least one first arrangement which can be structured to provide at least one first transmitted radiation along a first axis and at least one second transmitted radiation along a second axis. The first and second transmitted radiations can impact the structure and generate respective first and second returned radiation. The first and second axis can be provided at a predetermined angle with respect with one another which is greater than 0. Further, at least one second arrangement can be provided which can be configured to receive data associated with the first and second returned radiations, and determine at least one relative velocity between the structure and the first arrangement along the first and second axes. | 07-24-2014 |
20140206624 | TREATMENT OF LEUKEMIA - Compositions and methods for the treatment of leukemia by inhibiting FOXO signaling are described. | 07-24-2014 |
20140204604 | IMAGING SYSTEM AND RELATED TECHNIQUES - A method and apparatus for imaging using a double-clad fiber is described. | 07-24-2014 |
20140200484 | APPARATUS AND METHOD FOR TISSUE BIOPSY - Exemplary embodiments of an apparatus can be provided for obtaining portions or samples of tissue from a target region of a biological tissue. One or more needles can be provided that have a small internal diameter, e.g., about 1 mm or less, and the needles can be configured to extract the tissue portions when the needles are inserted into and withdrawn from the tissue. Windows and/or markings can be provided on the wall of the needles to facilitate access to the sample. The needles can be provided in an enclosure, and an actuator can be provided to direct the needles into the tissue and/or withdraw them. A plurality of tissue portions having known relative locations in the target region can be obtained, and extraction of the tissue portions can be well-tolerated by the tissue as compared with conventional punch biopsies or the like. | 07-17-2014 |
20140200251 | ETOMIDATE ANALOGUES WITH IMPROVED PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES - The invention is directed to compounds according to formula (I): | 07-17-2014 |
20140199399 | USE OF TGF-BETA ANTAGONISTS TO TREAT INFANTS AT RISK OF DEVELOPING BRONCHOPULMONARY DYSPLASIA - The disclosure relates to methods of treating an infant at risk of developing bronchopulmonary dysplasia, including premature infants, by administering a TGF-β antagonist during the perinatal period, including the prenatal period and/or the postnatal period. For administration during the prenatal period, the TGF-β antagonist can be administered either directly to the infant in utero, or indirectly by administration to the mother. | 07-17-2014 |
20140199314 | METHODS AND COMPOSITIONS FOR REGULATING IRON HOMEOSTASIS BY MODULATION OF BMP-6 - Modulation of iron homeostasis by regulating BMP-6 activity is provided. Methods of using BMP-6 and BMP-6 protein-specific reagents, such as antibodies, for altering serum iron levels in humans are provided. Such antibodies are useful in pharmaceutical compositions for the prevention and treatment of anemia and anemia of inflammation. | 07-17-2014 |
20140194736 | METHOD, APPARATUS AND COMPUTER ACCESSIBLE MEDIUM FOR PROVIDING SIGNAL AND CONTRAST ENHANCEMENT(S) IN OPTICAL IMAGING METHODS - A system for facilitating imaging of an anatomical structure(s) can be provided, and can include, for example, a substance which can induce a change in the anatomical structure(s) when applied to the anatomical structure(s), and an imaging arrangement which can be configured to generate an image of the anatomical structure(s) based on the change of the anatomical structure(s) when the substance is applied. The imaging arrangement can include an apparatus which can be configured to (i) illuminate the anatomical structure(s) with a first electro-magnetic radiation(s), and (ii) receive a second electro-magnetic radiation from the anatomical structure(s) that can be based on the first electro-magnetic radiation. The change can affect a characteristic(s) of the second electro-magnetic radiation. | 07-10-2014 |
20140194613 | USE OF MICROVESICLES IN DIAGNOSIS AND PROGNOSIS OF MEDICAL DISEASES AND CONDITIONS - The presently disclosed subject matter is directed to methods of aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a subject by detecting a biomarker in microvesicles isolated from a biological sample from the subject. | 07-10-2014 |
20140194366 | OVARIAN CANCER STEM CELLS AND METHODS OF ISOLATION AND USES THEREOF - The present invention generally relates to methods, assays, compositions and kits related to a subpopulation of ovarian cancer stem cells which are selected or enriched by chemotherapeutic agents and inhibited by MIS (Mullerian Inhibiting Substance) and MIS mimetics. In particular, the present invention relates to a population of CD44+/CD24+/EpCam+/ECad− subpopulation of ovarian cancer stem cells. The present invention also provides methods to screen a subject with ovarian cancer to identify if they have an ovarian cancer comprising CD44+/CD24+/EpCam+/ECad− ovarian cancer stem cells, and methods to identify and enrich or isolate for such ovarian cancer cell populations. | 07-10-2014 |
20140193913 | METHODS AND COMPOSITIONS FOR HOMOLOGOUS RECOMBINATION IN HUMAN CELLS - The methods and compositions described herein are based, in part, on the discovery of a stem cell state in human cells that resembles the morphology observed in murine-derived stem cells. Induction of such a state in human stem cells permits an increase in the efficiency of homologous recombination. Thus, the methods and compositions described herein relate to cells and methods for increasing the efficiency of homologous recombination in human stem cells. | 07-10-2014 |
20140187999 | APPARATUS, SYSTEM AND METHOD FOR PROVIDING IMAGE-GUIDED IN-VIVO BIOPSY WITH AT LEAST ONE CAPSULE - An exemplary apparatus for obtaining a tissue sample(s) within a luminal anatomical structure can be provided. For example, an imaging first arrangement can be configured to generate an image of a portion(s) of the luminal anatomical structure, and a second arrangement can be configured to extract the tissue sample(s) based on the image. A pill-shaped housing can at least partially enclose the first and second arrangements. | 07-03-2014 |
20140187970 | OPTICAL PROBE APPARATUS, SYSTEMS, METHODS FOR GUIDING TISSUE ASESSMENT - An exemplary system can be provided for obtaining information associated with at least one tissue. The exemplary system can include at least one waveguide first arrangement which can provide at least one first radiation to the tissue(s), and which can receive at least one optical second radiation from the at least one tissue. Further, at least one configuration can be provided that can transceive at least one electrical signal to and from at least one portion of the system. In addition, at least one computing second arrangement can be provided which may configured to obtain the information based on the second radiation and data corresponding to the electrical signal(s). The data can comprise a position of the portion(s). | 07-03-2014 |
20140187510 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY - The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant Wnt/β-catenin signaling and administering to the selected subject a compound selected from the group consisting of those set forth in Table 1, Table 2, and a pharmaceutically acceptable salt thereof. A method of similarly modulating the Wnt/β-catenin pathway in a subject is also discussed. | 07-03-2014 |
20140186400 | METHODS AND COMPOSITIONS FOR TREATING AUTOIMMUNE DISEASES - The invention features methods for increasing or maintaining the number of functional cells of a predetermined type, for example, insulin producing cells of the pancreas, blood cells, spleen cells, brain cells, heart cells, vascular tissue cells, cells of the bile duct, or skin cells, in a mammal (e.g., a human patient) that has injured or damaged cells of the predetermined type. | 07-03-2014 |
20140186277 | Methods and Compositions for Reducing Skin Damage - The RhoE GTPase pathway has been identified as a target for screening and treatment methods for the prevention and/or reduction of short- and long-term UVB-induced skin damage, e.g., the prevention and/or reduction of UVB-induced wrinkles. The invention thus features screening and treatment methods for prevention or reduction of UVB-induced skin damage, and related compositions, e.g., cosmetic compositions. | 07-03-2014 |
20140183794 | METHODS FOR MAKING OXIDATION RESISTANT POLYMERIC MATERIAL - The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein. | 07-03-2014 |
20140178901 | Molecular Analysis of Tumor Samples - This invention relates to methods for diagnosing cancer, e.g., cancer of epithelial origin, by detecting the presence of tumor cells in a sample, based (at least in some embodiments) on the quantification of levels of four biomarkers, MUC1, EGFR, EpCAM, and HER2. In some embodiments, the methods are performed using diagnostic magnetic resonance (DMR), e.g., with a portable relaxometer or MR imager. | 06-26-2014 |
20140163582 | METHOD AND APPARATUS FOR DISCONTINUOUS DERMABRASION - Exemplary embodiments of method and apparatus are provided for resurfacing of skin that includes formation of a plurality of small holes, e.g., having widths less than about 1 mm or 0.5 mm. For example, such small holes can be produced using a mechanical apparatus that includes one or more abrading elements provided at the end of one or more rotating shafts, thus avoiding generation of thermal damage as occurs with conventional laser resurfacing procedures and devices. The holes thus formed can be well-tolerated by the skin, and may exhibit shorter healing times and less swelling than conventional resurfacing procedures. The fractional surface coverage of the holes can be between about 0.1 and 0.7, or between about 0.2 and 0.5. The method and apparatus can produce cosmetic improvements in the skin appearance by eliciting a healing response. | 06-12-2014 |
20140162285 | Methods of Modulating Vesicular Trafficking - Described are methods of identifying compounds useful for modulating vesicular trafficking, particularly those that disrupt the interactions between ARNO and the V-ATPase a2-subunit. Also described are peptides that modulate vesicular trafficking. | 06-12-2014 |
20140162277 | METHOD FOR PREDICTING RESPONSIVENESS TO DRUGS - The present invention provides a novel method to determine the likelihood of effectiveness of a treatment in an individual affected with or at risk for developing cancer. The method involves detecting the presence or absence of Met amplification in an individual. The presence of Met amplification indicates that a Met targeting treatment is likely to be effective. Preferably, the Met targeting treatment is PHA-665752 or PF-02341066. In addition, the present methods allow for the detection of cancer in an individual, wherein the presence of Met amplification indicates that cancer is present and further that it will be treatable, namely with a Met targeting treatment. | 06-12-2014 |
20140161720 | TREATMENT OF ANGIOGENIC- OR VASCULAR-ASSOCIATED DISEASES - Described herein are methods and compositions comprising a compound of formula (I), e.g., dehydro-alpha-lapachone, or an analog, derivative, isomer, prodrug, or pharmaceutically acceptable salt thereof, for treatment and/or prevention of angiogenic- or vascular-associated diseases or disorders. The compound has anti-vascular activity. In some embodiments, the compound has anti-vascular activity that targets pathways other than VEGF pathways. In some embodiments, the compound or the composition further comprises anti-tumor activity. In some embodiments, the compound or the composition can decrease adhesion or motility of at least one cell (e.g., endothelial cells or cancer cells). | 06-12-2014 |
20140160482 | OPTICAL SYSTEM FOR ENDOSCOPIC INTERNALLY-REFERENCED INTERFEROMETRIC IMAGING, AND METHOD FOR EMPLOYING THE SAME - An exemplary arrangement can be provided which can include a lens arrangement which can have at least two reflecting surfaces on opposing sides thereof, each of the reflecting surfaces can have a reflectivity that can be greater than 10%. The lens arrangement can include a gradient index lens, and can have a refractive optical element, a diffractive optical element, a planar convex lens, an aspheric lens, a ball lens or a cylindrical lens. | 06-12-2014 |
20140148413 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING ORGAN INJURY AND/OR DYSFUNCTION - The present embodiments relate to compositions and methods for treating the inflammatory response in a tissue or organ, such as the liver, by contacting the tissue with a tissue-specific gap junction inhibitor; and compositions and methods of reducing the toxicity of an agent by administering a gap junction inhibitor either simultaneously or sequentially with exposure to the agent. For example, inhibition of the liver-specific gap junction connexin 32 by 2 aminoethyoxydiphenyl-borate, effectively treats and/or prevents hepatotoxicity. | 05-29-2014 |
20140147839 | MICROVESICLE-BASED ASSAYS - Methods are disclosed herein for assaying a biological sample or a bodily fluid obtained from a subject by isolating, obtaining or using a microvesicle fraction from the biological sample or bodily fluid and detecting in the microvesicle fraction the presence or absence of a genetic aberration in an IDH1, IDH2, TP53, PTEN, CDKN2A, NF1, EGFR, RB1, PIK3CA, or BRAF gene. The methods may be used for aiding the diagnosis, prognosis, monitoring, or therapy selection in relation to a disease or other medical condition (e.g., a glioma) in a subject. | 05-29-2014 |
20140147441 | COMPOSITIONS CONTAINING ALPHA-1-ANTITRYPSIN AND METHODS FOR USE - Methods and compositions for treating patients (e.g., patients who are insulin resistant, patients who have diabetes, or are at risk for developing diabetes) are disclosed herein. The methods can include administration of an α1 antitrypsin (AAT) polypeptide or an agent, such as a nucleic acid molecule or organic compound, that promotes the expression or activity of α1-antitrypsin. | 05-29-2014 |
20140142160 | Polycomb-associated Non-Coding RNAs - This invention relates to long non-coding RNAs (lncRNAs), libraries of those ncRNAs that bind chromatin modifiers, such as Polycomb Repressive Complex 2, inhibitory nucleic acids and methods and compositions for targeting lncRNAs. | 05-22-2014 |
20140142150 | TREATING NEUROPSYCHIATRIC DISORDERS - The specification provides methods of treating a subject suffering from a neuropsychiatric disorder and methods of determining whether a subject is suffering from or at risk for developing a neuropsychiatric disorder or likely to respond to a specified treatment method. | 05-22-2014 |
20140140970 | Use of Secretor, Lewis and Sialyl Antigen Levels in Clinical Samples as Predictors of Risk for Disease - An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewis | 05-22-2014 |
20140140927 | CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT - Novel cromolyn analogs useful as imaging agents for detecting atherosclerotic plaques and for treating atherosclerosis and Alzheimer's Disease, and methods of making the cromolyn analogs, are disclosed. The cromolyn analogs have the general formula: | 05-22-2014 |
20140136229 | Drug Labeling - Disclosed are systems and methods for enabling transfer of a drug from a first drug container to a second drug container including a drug identification component that recognizes a first drug container to retrieve drug identifying data for the drug, a storage medium that stores a site-specific database comprising attributes and associated values for a set of drugs including the drug in the first drug container, a processor that obtains the drug identifying data and the attributes and associated values for the drug and produces information about the drug using the drug identifying data and the attributes and associated values, a rules engine that applies one or more rules to the information about the drug to generate drug handling information, and an output unit that outputs markings comprising the drug handling information in human-readable or machine-readable form, or both, to be associated with the second container. | 05-15-2014 |
20140134644 | METHODS AND KITS FOR DIAGNOSING SJOGREN'S SYNDROME - The invention features methods and kits for determining the presence of, or a predisposition to develop, Sjögren's syndrome in humans. The invention features methods to detect changes in the levels of one or more LMP-2 protein isoforms, in particular phosphorylated isoforms of LMP-2, and to detect changes in cellular protein phosphorylation and ubiquitination in samples from Sjögren's patients. | 05-15-2014 |
20140134131 | Immune Regulation - A method of regulating the immune system of a subject that involves removing antigen presenting cells from subject and loading preselected class II peptide fragments onto the subjects APC's outside the body of the subject. | 05-15-2014 |
20140127685 | COMPOSITIONS AND METHODS FOR DIAGNOSING AUTISM - The invention provides methods featuring the use of polymorphisms in the JARID2 gene to diagnosis autism. | 05-08-2014 |
20140127267 | FUNGAL-DERIVED CARBOHYDRATE-CONJUGATED SCAFFOLD - The present invention provides for compositions and methods for a purified fungal carbohydrate-linked polymer bead platform, which can serve as an artificial fungus-like particle to measure specific patient immune responses to fungal carbohydrate antigens. A specific embodiment comprises a purified β-1,3-glucan chemically conjugated to a polymer bead. | 05-08-2014 |
20140120621 | TGF-BETA RECEPTOR INHIBITORS TO ENHANCE DIRECT REPROGRAMMING - In general, iPS cells are produced by delivery of stem cell-associated genes into adult somatic cells (e.g., fibroblasts). Described herein are methods for enhancing the efficiency and rate of induced pluripotent stem cell production by treating somatic cells with a transforming growth factor-beta receptor (TGFβR) inhibitor. Also described herein are iPS cell compositions made according to the methods described herein and iPS cell compositions comprising an iPS cell in an admixture with a TGFβR inhibitor. Further described herein are kits for producing iPS cells using a TGFβR inhibitor. | 05-01-2014 |
20140113832 | ENGINEERED THIOREDOXIN-LIKE FOLD PROTEINS - The invention features compositions based on thioredoxin-like fold protein domains described as engineered thioredoxin-like fold proteins (ETRXs). These proteins include one or more artificially diversified thioredoxin-like fold protein domains; each domain may be originated from the same or different thioredoxin-like fold protein domains. Features of the invention also include methods for identifying and preparing an enriched composition of target binding, loop-diversified ETRXs with additional sequence variations to improve affinity, stability, selectivity, or solubility. The invention also features compositions of ETRXs substituted with prosthetic groups, polymers, proteins, nucleic acids, carbohydrates, metals, natural or synthetic small molecules and toxins. | 04-24-2014 |
20140106378 | METHODS FOR DIAGNOSIS AND PROGNOSIS OF EPITHELIAL CANCERS - The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples. The invention is also directed to markers for therapeutic efficacy. | 04-17-2014 |
20140098342 | SYSTEM AND METHOD FOR CORNEAL IRRADIATION - A device and method for use thereof to illuminate a visual system of a subject includes a light-transforming optical element configured to transform a substantially collimated beam of light into light having a diverging spatial distribution. Optionally, light having such spatial distribution includes a plurality of diverging beams of light. An imaging system mechanically cooperated with the light-transforming optical element is configured such as to form an image of the light-transforming optical element at an image surface associated with the eye that is distant from the retina. The irradiance level at the image surface exceeds that at the retina. Optionally, the image surface adjoins or includes the cornea. The imaging system may include an optical system containing refractive and/or reflective optical elements. | 04-10-2014 |
20140097559 | METHODS FOR MAKING OXIDATION-RESISTANT CROSS-LINKED POLYMERIC MATERIALS - The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (α-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (α-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided. | 04-10-2014 |
20140088035 | TREATING SCHIZOPHRENIA - The specification provides methods of treating a subject suffering from a negative symptom of schizophrenia and methods of determining whether a subject is suffering from or at risk for developing a negative symptom of schizophrenia. | 03-27-2014 |
20140086907 | MULTIMODAL TRAIL MOLECULES AND USES IN CELLULAR THERAPIES - Described herein are novel compositions comprising multimodal TRAIL agents and cells engineered to express such multimodal TRAIL agents, including cells encapsulated in a scaffold or matrix, for use in the treatment of disorders such as cancer. | 03-27-2014 |
20140086842 | SCREENING METHODS USING G-PROTEIN COUPLED RECEPTORS AND RELATED COMPOSITIONS - The present invention provides screening methods for GPCRs based on the discovery that the affinity of a receptor agonist for a GPCR (such as the parathyroid hormone receptor) when not bound to a G-protein is correlated with the length of time over which the agonist is effective, independently of its pharmacokinetic properties. The invention also provides PTH- and PTHrP-derived polypeptides. | 03-27-2014 |
20140081384 | BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME - The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits. | 03-20-2014 |
20140080775 | MOLECULAR MODULATORS OF THE WNT/BETA-CATENIN PATHWAY - The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant Wnt/β-catenin signaling and administering to the selected subject at least one compound selected from the group consisting of those set forth in Table 1, Table 2, Table 3, and a pharmaceutically acceptable salt thereof. A method of similarly modulating the Wnt/β-catenin pathway in a subject is also discussed. | 03-20-2014 |
20140073915 | APPARATUS AND METHOD FOR VOLUMETRIC IMAGING OF BLOOD FLOW PROPERTIES - Apparatus, method and computer accessible medium can be provided for determining presence of individual scattering objects in at least one blood vessel. For example, with at least one detector arrangement, it is possible to detect interferometric radiation from at least one portion of the blood vessel(s), and provide data associated therewith. The interferometric radiation can be based on a first radiation provided from the portion at a second radiation provided from a reference. Further, with a computer arrangement, it is possible to determine the presence of the individual scattering objects in the portion of the blood vessel(s) based on the data. It is also possible to identify individual passage of the scattering objects and/or measure at least one characteristic of the passage. | 03-13-2014 |
20140073687 | EFFICIENT PROTEIN EXPRESSION IN VIVO USING MODIFIED RNA (MOD-RNA) - Aspects of the invention described herein relate to synthetic, modified RNAs and their use in vivo to modulate gene expression. Aspects of the invention further relate to the use of these synthetic, modified RNAs in myocytes, cardiomyoctes, and tumors. | 03-13-2014 |
20140066454 | Antibiotic Tolerance Inhibitors - The present disclosure relates to benzimidazole-benzamide derivatives, and the use thereof, e.g., to treat infections. | 03-06-2014 |
20140057829 | Citrullinated Histone H3 (Cit H3) in Septic Shock - Methods of diagnosing sepsis, severe sepsis, or septic shock and predicting prognosis in subjects with septic shock, based on levels of citrullinated histone H3 (Cit H3) in the subject, e.g., in a sample comprising serum (e.g., whole blood, serum, or plasma), cerebrospinal fluid, urine, saliva, or peritoneal fluid from the subject. | 02-27-2014 |
20140056812 | Imaging Beta Cell Mass - The present disclosure provides compositions and methods based on peptide-detectable agent conjugates that are useful for imaging beta cell mass. | 02-27-2014 |
20140051746 | METHODS TARGETING MIR-128 FOR REGULATING CHOLESTEROL/LIPID METABOLISM - Methods for targeting microRNA 128 (miR-128) for regulating cholesterol/lipid metabolism and insulin sensitivity. | 02-20-2014 |
20140050707 | MIR-150 FOR THE TREATMENT OF BLOOD DISORDERS - The invention provides methods of treating certain blood related disorders, in particular, thrombocytopenia and anemia comprising increasing miR-150 expression or inhibiting miR-150 in progenitor cells respectively. | 02-20-2014 |
20140045915 | CANCER-RELATED BIOLOGICAL MATERIALS IN MICROVESICLES - Disclosed herein are methods for assaying a biological sample from a subject by analyzing components of microvesicle fractions in aid of risk, diagnosis, prognosis or monitoring of or directing treatment of the subject for, a disease or other medical condition in the subject. Also disclosed are methods of treatment and identifying biomarkers using a microvesicle fraction of a subject. Kits, pharmaceutical compositions, and profiles related to the methods are also disclosed. | 02-13-2014 |
20140038953 | COMPOSITIONS AND METHODS FOR CARDIOVASCULAR DISEASE - The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to reduce circulating levels of ApoB-100 or LDL. These compounds may also be used to treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia. | 02-06-2014 |
20140030788 | MICROSCALE AND NANOSCALE STRUCTURES FOR MANIPULATING PARTICLES - The devices and systems described herein include one or more fluid paths, e.g., channels, and one or more selectively permeable obstacles arranged in the fluid path(s), each including a plurality of aligned nanostructures, e.g., nanotubes or nanorods, defining an outer surface of the obstacle and an internal network of voids. The obstacle(s) can further include binding moieties applied to the outer surface and/or to the surfaces of the individual nanostructures within the obstacle(s). The devices can be manufactured by forming the dense groupings of nanostructures to extend outwards and upwards from a substrate; forming a fluidic channel, bonding the fluidic channel to the substrate; and optionally applying binding moieties to the obstacles. The devices can be used to manipulate cells within fluid samples. | 01-30-2014 |
20140030231 | METHODS AND COMPOSITIONS FOR PRESERVING TISSUES AND ORGANS - The present invention generally relates to methods and compositions to determine viability of an organ for transplantation and other medical purposes. One aspect of the invention relates to a method for assessing the viability of an organ by measuring the energy parameters to determine the energy level of the organ by determining the stored cellular energy (e.g., ATP levels), and/or energy consumption over a particular time period of viability. The energy parameters can be compared to reference energy parameters as a highly accurate and reliable prediction of viable cell yield, and organ viability. Another aspect of the invention relates methods to preserve or extend the time period of viability of an organ any combination of (i) preservation perfusion of the organ to prevent ischemic damage, (ii) chemical metabolic suppression of the organ e.g., using metabolic suppressants, (iii) metabolic suppression by physical or environmental conditions, e.g., sub-zero non-freezing storage. | 01-30-2014 |
20140017816 | WATER RELAXATION-BASED SENSORS - This invention relates to magnetic resonance-based sensors and related methods. | 01-16-2014 |
20130344004 | MATRIX METALLOPROTEASE TARGETING NUCLEIC ACIDS - A reporter conjugate for non-invasive detection (e.g., imaging) of matrix metalloprotease (MMP) gene expression in vivo is disclosed. The conjugate includes a targeting nucleic acid linked to a contrast agent, such as a paramagnetic label that can be used with magnetic resonance (MR) imaging. The targeting nucleic acid can be an antisense strand that hybridizes to a portion of a messenger RNA encoded by the gene whose expression is to be imaged. In some embodiments, the contrast agent is a chelated metal such as gadolinium or dysprosium. The invention also features methods to detect MMP gene expression in various tissues, including the brain. | 12-26-2013 |
20130338510 | APPARATUS FOR APPLYING A PLURALITY OF ELECTRO-MAGNETIC RADIATIONS TO A SAMPLE - An apparatus for applying electro-magnetic radiations to a sample is provided. The apparatus can include an arrangement which has a specific portion with a plurality of channels. One channel(s) can facilitate a first radiation to be forwarded to the sample within an anatomical structure, and another channel(s) can facilitate a second radiation to be forwarded to the sample. The first radiation can have a first wavelength band, and the second radiation can have a second wavelength band, which can be substantially different from the first wavelength band. The first radiation can be delivered to a first area of the sample, and the second radiation can be delivered to a second area of the sample. Each of the channels can facilitate a particular radiation(s) to be forwarded to the sample that is within an anatomical structure of the sample, the radiations being delivered to different areas of the sample. | 12-19-2013 |
20130323708 | ISOLATED ADULT CELLS, ARTIFICIAL ORGANS, REHABILITATED ORGANS, RESEARCH TOOLS, ORGAN ENCASEMENTS, ORGAN PERFUSION SYSTEMS, AND METHODS FOR PREPARING AND UTILIZING THE SAME - One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ. | 12-05-2013 |
20130323305 | COMPOSITIONS AND METHODS COMPRISING ENERGY ABSORBING MATERIALS FOR FOLLICULAR DELIVERY - The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets. | 12-05-2013 |
20130323220 | TAL-Tet1 Fusion Proteins and Methods of Use Thereof - Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in DNA, and methods of use thereof. | 12-05-2013 |
20130316935 | METHOD TO DETERMINE RESPONSIVENESS OF CANCER TO EPIDERMAL GROWTH FACTOR RECEPTOR TARGETING TREATMENTS - Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) targeting treatment. The detection of these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug. | 11-28-2013 |
20130315999 | COMPOSITIONS AND METHODS COMPRISING ENERGY ABSORBING COMPOUNDFS FOR FOLLICULAR DELIVERY - The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets. | 11-28-2013 |
20130315827 | Compounds and Compositions for the Detection and Treatment of Alzheimer's Disease and Related Disorders - One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera. | 11-28-2013 |
20130314716 | SPECKLE REDUCTION IN OPTICAL COHERENCE TOMOGRAPHY BY PATH LENGTH ENCODED ANGULAR COMPOUNDING - Accordingly, exemplary embodiments of an apparatus obtaining information associated with a structure can be provided. For example, with a first arrangement, it is possible to separate at least one first electro-magnetic radiation into a first radiation and a second radiation forwarded to the structure, with the first and second radiations having different path lengths. Using a second arrangement, it is possible to receive third and fourth radiations from the structure associated with the first and second radiations and a fifth radiation received from a reference. Further, with a third arrangement, it is possible to generate data corresponding to an amount of a ranging depth within the structure associated with the second arrangement. For example, a difference between the path lengths of the first and second radiations is equal or greater than the ranging depth. | 11-28-2013 |
20130314085 | Interface for Medical Imaging Device - A system and method for modifying an imaging plane of a medical imaging device is presented. An electronic device includes a tilt sensor. The electronic device is configured to monitor a tilt of the electronic device. A computer is configured to receive an indication of the tilt of the electronic device, translate the indication of the tilt of the electronic device into a corresponding movement of the imaging plane of the medical imaging device, and transmit an instruction to the medical imaging device to cause the corresponding movement of the imaging plane. The medical imaging device may include an magnetic resonance imaging (MRI) system. | 11-28-2013 |
20130310643 | APPARATUS, DEVICE AND METHOD FOR CAPSULE MICROSCOPY - An exemplary apparatus for obtaining data for at least one portion within at least one luminal or hollow sample can be provided. For example, the apparatus can include a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the portion(s). The apparatus can also include a wavelength dispersive second arrangement, which can be configured to disperse the electromagnetic radiation(s). A housing can be provided with a shape of a pill, and enclosing the first and second arrangements. | 11-21-2013 |
20130310351 | Treating Long QT Syndrome - This document relates to compounds useful for treating cardiac arrhythmias, for example, long QT syndrome. Also provided herein are methods and materials for using such compounds to shorten myocardial repolarization time in a patient. | 11-21-2013 |
20130309170 | Compositions And Methods For In Vivo Imaging - This document relates to compounds useful for targeting PARP1. Also provided herein are methods for using such compounds to detect and image cancer cells. | 11-21-2013 |
20130307170 | BLOOD SUBSTITUTES AND USES THEREOF - The invention relates to blood substitute compositions, and methods of use thereof. Described herein are compositions in which hemoglobin is maintained substantially in the reduced form of hemoglobin as opposed to the oxidized methemoglobin form through inclusion of an oxido-reductase enzyme and reducing agent within a vesicle with the hemoglobin. The vesicles additionally can comprise a dismutase, a catalase, and an electron acceptor, each of which contribute to either the maintenance of hemoglobin in the active oxygen carrying state or provide a benefit not achieved with free hemoglobin. | 11-21-2013 |
20130303842 | BLOOD VESSEL GRAFTS FOR REPAIR, RECONSTRUCTION AND FILLER MATERIALS - Compositions comprising aortic material and methods for using harvested blood vessels (e.g., arteries or veins e.g., aortae) graft procedures, e.g., for restoring and repairing luminal structures (e.g., in the aerodigestive tract, such as the larynx, pharynx, and esophagus); as tissue fillers (e.g., injectable morselized blood vessel tissues, for use in cosmetic applications and functional sphincter enhancement); and as biological structural supports (e.g., intact portions of aortae, for use in repairing abdominal wounds, anastomoses, bony repairs, and the heart). | 11-14-2013 |
20130303461 | METHODS FOR DETERMINING A NUCLEOTIDE SEQUENCE - The technology described herein is directed to methods of determining oligonucleotide sequences, e.g. by enriching target sequences prior to sequencing the sequences. | 11-14-2013 |
20130302329 | DIAGNOSTIC TESTS FOR IMMUNE REACTIVITY WITH HUMAN ENDOTHELIAL CELL GROWTH FACTOR - The present invention provides for methods and compositions for identifying and detecting autoantigens. Candidate autoantigens are identified by obtaining a subject sample from which HLA-DR-presented peptides are collected and identified using mass spectometry, then synthesized and reacted with the same subject peripheral blood or effected tissue. In particular, the present invention provides for endothelial cell growth factor as a novel autoantigen biomarker for Lyme disease-associated arthritis. | 11-14-2013 |
20130295588 | COUNTING PARTICLES USING AN ELECTRICAL DIFFERENTIAL COUNTER - This disclosure relates to methods and devices to count particles of interest, such as cells. The methods include obtaining a fluid sample that may contain particles of interest; counting all types of particles in a portion of the sample using a first electrical differential counter to generate a first total; removing any particles of interest from the portion of the fluid sample; counting any particles remaining in the portion of the fluid sample using a second electrical differential counter after the particles of interest are removed to generate a second total; and calculating a number of particles of interest originally in the fluid sample by subtracting the second total from the first total, wherein the difference is the number of particles of interest in the sample. These methods and related devices can be used, for example, to produce a robust, inexpensive diagnostic kit for CD4+ T cell counting in whole blood samples. | 11-07-2013 |
20130288961 | METHODS FOR TREATING STEATOTIC DISEASE - Methods for treating fatty liver disease, e.g., hepatic steatosis, using peptide fragments of the C-terminal end of glucagon-like peptide-1 (GLP-1), e.g., GLP-1(28-36). | 10-31-2013 |
20130287688 | NOVEL COMPOSITIONS AND USES OF ANTI-HYPERTENSION AGENTS FOR CANCER THERAPY - Methods and compositions for improving the delivery and/or efficacy of a therapy (e.g., a cancer therapy) are disclosed. In one embodiment, methods and compositions for treating or preventing a cancer (e.g., a solid tumor such as a desmoplastic tumor) by administering to a subject an anti-hypertensive agent, as a single agent or in combination with a microenvironment modulator and/or a therapy, e.g., a cancer therapy (for example, a therapeutic agent or therapy, including immunotherapy (e.g., antibodies, vaccine, cell-based), nanotherapeutics, radiation therapy, photodynamic therapy, low molecular weight chemotherapeutics, molecularly targeted therapeutics and/or oxygen radical) are disclosed. | 10-31-2013 |
20130274235 | TREATMENT OF MOTOR NEURON DISEASE - Provided herein are methods and compositions for the treatment of motor neuron diseases including, for example, amyotrophic lateral sclerosis. Suitable therapeutic agents include, for example, agents that up-regulate the expression IGF-II or guanine deaminase in a cell. | 10-17-2013 |
20130271250 | Self-Assembled Magnetic Arrays - A magnetic device includes a substrate and an array including a plurality of magnetic particles, in which a magnetic dipole moment direction of each magnetic particle in a majority of the magnetic particles in the array alternates with respect to a magnetic dipole direction of a directly adjacent magnetic particle or directly adjacent magnetic particles in the array. | 10-17-2013 |
20130259805 | DEVELOPMENT AND SCREENING OF CONTRAST AGENTS FOR IN VIVO IMAGING OF PARKINSON'S DISEASE - The invention provides compounds and a method for imaging aggregated α-synuclein, e.g., Lewy bodies or Lewy neurites, in a tissue or organ. | 10-03-2013 |
20130253496 | TREATMENT SYSTEMS FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS - The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling. | 09-26-2013 |
20130253495 | TREATMENT SYSTEMS FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS AND TREATMENT SYSTEMS FOR AFFECTING SUBCUTANEOUS LIPID-RICH CELLS - The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling. | 09-26-2013 |
20130253494 | SYSTEMS FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS AND SYSTEMS FOR REMOVING HEAT FROM A TARGET TISSUE MASS - The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling. | 09-26-2013 |
20130253493 | TREATMENT SYSTEMS FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS - The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling. | 09-26-2013 |
20130253384 | SYSTEMS FOR AFFECTING SUBCUTANEOUS LIPID-RICH CELLS, SYSTEMS FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS, AND SYSTEMS FOR REDUCING SUBCUTANEOUS LIPID-RICH CELLS - The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling. | 09-26-2013 |
20130245773 | HIGHLY CRYSTALLINE CROSS-LINKED OXIDATION-RESISTANT POLYETHYLENE - The present invention relates to methods for making highly crystalline cross-linked polymeric material, for example, highly crystalline cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped highly crystalline cross-linked polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein. | 09-19-2013 |
20130245093 | METHODS TARGETING MIR-33 MICRORNAS FOR REGULATING LIPID METABOLISM - Compositions comprising nucleic acid sequences that target MiR-33a/b microRNAs are described, together with uses of the same in the treatment of certain disorders related to elevated serum triglyceride levels and obesity. | 09-19-2013 |