The Governors of the University of Alberta Patent applications |
Patent application number | Title | Published |
20160082158 | CELLULAR TRANSPLANT SITE - A method of preparing a transplant site for cellular transplantation in a mammal includes the steps of inserting a foreign body comprising a biomaterial into an internal tissue; and removing the foreign body after the tissue surrounding the foreign body has undergone an inflammatory response but before significant fibrous encapsulation has occurred, leaving a neovascularized lumen suitable to receive transplanted cells or islets. | 03-24-2016 |
20160061830 | BACTERIOPHAGE-BASED BIOSENSOR FOR MICROBIAL DETECTION - A biosensor for detecting a microorganism in a sample includes a polymer matrix and an immobilized layer of bacteriophages on the surface of the polymer matrix, wherein interaction of the bacteriophage with the microorganism causes a detectable physicochemical change in the polymer matrix. A method of detecting a microorganism in a sample using the biosensor includes the steps of contacting the sample with the biosensor; allowing the bacteriophage to bind to the microorganism in the sample; and detecting a physicochemical change in the polymer matrix, the change being indicative of the presence of the microorganism. | 03-03-2016 |
20160059209 | MODIFIED ALKALI METAL NANOTITANATES FOR HYDROGEN SULFIDE ADSORPTION - A hydrogen sulphide adsorbent is formed from an alkali metal nanotitanate having a portion of the alkali metal cations exchanged with metal cations reactive with hydrogen sulphide, and heat treated. A method for producing the adsorbent includes the steps of mixing an alkali metal nanotitanate in powder form into an aqueous metal cation solution to produce a slurry, which is subsequently dehydrated to produce a powder, which is heat treated. A low temperature method for removing hydrogen sulphide from a gaseous mixture involves exposing the gaseous mixture to the aforementioned adsorbent, at a temperature less than 250° C. The adsorbent maintains a high adsorption capacity over a range of activation temperatures and humidity conditions. | 03-03-2016 |
20160058892 | PREPARATION OF BONE-SEEKING SUPERPARAMAGNETIC IRON NANOPARTICLES AS CONTRAST AGENTS AND METHODS FOR USING THE SAME - Described herein are compositions having a nanoparticle that is conjugated to at least one bone targeting moiety, wherein the bone targeting moiety is bonded to the nanoparticle by a linker, wherein the nanoparticle contains iron, and wherein the compositions are neutral or pharmaceutically acceptable salts or esters. Also described herein are methods of making these compositions. In one aspect, the nanoparticles serve as contrast agents for magnetic resonance imaging of bone metabolism. The compounds, compositions, and methods described herein can be used in a number of therapeutic applications including diagnosing or monitoring fracture and/or the progress of conditions associated with bone loss, which include, but are not limited to, osteoporosis, Paget's disease, osteolytic tumors, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis, osteopenia, and hypercalcemia. | 03-03-2016 |
20160045584 | CAMPYLOBACTER VACCINE - The present application provides a vaccine composition comprising: bacteria engineered to express at least one N-glycan of | 02-18-2016 |
20160039902 | CHANNELRHODOPSIN VARIANTS AND USES THEREOF - CsChrimson light-activated ion channel polypeptides, their encoding polynucleotides, and variants thereof are provided. Methods of introducing and using CsChrimson light activated ion channels and variants thereof for to alter cell activity and function are also provided. | 02-11-2016 |
20160024394 | PYROLYSIS REACTIONS IN THE PRESENCE OF AN ALKENE - Described herein are methods for producing branched alkanes and branched alkenes from the pyrolysis of radical precursors in the presence of one or more alkenes. The branched alkanes and branched alkene have numerous applications as fuels, plat form chemicals, and solvents. | 01-28-2016 |
20150379724 | CARDIAC SEGMENTATION WITH POINT CORRESPONDENCE - A time series of image frames in an anatomical scan is segmented. An image frame k in the time series of image frames is manually segmented. A non-rigid registration is then performed between the image frame k and a next image frame k+1 in the time series of image frames. A segmentation on the image frame k+1 is computed based on the non-rigid registration. Each subsequent image frame k+n in the time series of image frames is iteratively segmented using non-rigid registration with the segmented previous image frame k+(n−1) in the time series of image frames. | 12-31-2015 |
20150369740 | OPTOGENETIC PROBES FOR MEASURING MEMBRANE POTENTIAL - Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, cells comprising the polynucleotides, and cells comprising the polypeptides; and methods of using the variants. | 12-24-2015 |
20150365033 | GRID-CONNECTED INDUCTION MACHINE WITH CONTROLLABLE POWER FACTOR - A method and system for controlling the power factor of induction machines connected to power distribution grids are provided. In some embodiments, the method can comprise inserting an adjustable voltage source in series with one or more windings of a grid-connected induction machine such that the adjustable voltage source can be adjusted to manipulate the phase angle of the current flowing through the one or more windings relative to the phase angle of the grid voltage. The system can comprise an adjustable voltage source in series with one or more windings of a grid-connected induction machine such that the adjustable voltage source can be adjusted to manipulate the phase angle of the current flowing through the one or more windings relative to the phase angle of the grid voltage. | 12-17-2015 |
20150329686 | BIOCOMPOSITE MATERIALS DERIVED FROM ANIMAL PROTEIN - Biocomposite materials are derived from animal proteins, and, in particular, animal proteins derived from byproducts such as specified risk material. The composite materials are created by embedding a fibrous material with a polymer matrix comprising a hydrolysate from the animal protein and a crosslinking reagent such as an epoxy. | 11-19-2015 |
20150246957 | PARATHYROID HORMONE, INSULIN, AND RELATED PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS AND MAKING AND USING THEREOF - Described herein is insulin, an insulin-like growth factor, parathyroid hormone, a fragment of parathyroid hormone, or a parathyroid hormone related protein that includes at least one bone targeting moiety, wherein the bone targeting moiety is covalently bonded to the peptide. Also described herein are the methods of making these compositions that prevent or treat conditions associated with bone loss and preventing bone fractures, and/or the inability to initiate de novo bone turnover and stimulate bone fracture repair. | 09-03-2015 |
20150240289 | SOLID GEL AMPLIFICATION METHOD AND APPARATUS FOR PLATFORM MOLECULAR DIAGNOSTICS - The present invention provides for a novel system and method for amplification and detection of nucleic acids within a miniaturized device wherein sample administration occurs via capillary forces through a channel created by drying a hydrogel containing all components needed for a cell-free, enzymatic, nucleic-acid amplification system other than the template nucleic acid or precursor thereto, and wherein an aqueous sample is provided to the desiccated hydrogel, and the hydrogel is rehydrated, through capillary forces. | 08-27-2015 |
20150223679 | BLUE LIGHT-ACTIVATED ION CHANNEL MOLECULES AND USES THEREOF - The invention, in some aspects relates to light-activated ion channel polypeptides and encoding nucleic acids and also relates in part to compositions comprising light-activated ion channel polypeptides and methods using light-activated ion channel polypeptides to alter cell activity and function. | 08-13-2015 |
20150219652 | BINDING-INDUCED FORMATION OF DNA THREE-WAY JUNCTIONS FROM NON-DNA TARGETS - A method of detecting a non-DNA target includes the use of a first nucleic acid motif linked to a first affinity ligand which binds specifically to the target and having a first toehold domain and a first binding domain, and a second nucleic acid motif linked to a second affinity ligand which binds specifically to the target and having a second binding domain, wherein the first and second binding domains are complementary to each other. Upon contact with the target, the first and second nucleic acid motifs bind to form a target-ligand complex. The formation of the complex causes displacement of an output nucleic acid motif. This method may be used with detectable beacons in an imaging or diagnostic method, and particularly in a point of care diagnostic method. | 08-06-2015 |
20150192552 | DETECTOR FOR NITRO-CONTAINING COMPOUNDS COMPRISING FUNCTIONALIZED SILICON NANOCRYSTALS AND METHODS OF USE THEREOF - A detector and a method for the detection of nitro-containing compounds, such as explosives, is described. Detection is by observing the quenching of the photoluminescence of functionalized silicon nanocrystals, such as amine-functionalized silicon nanocrystals, oligonucleotide-functionalized silicon nanocrystals, oligomer or monolayer alkyl-functionalized silicon nanocrystals, aromatic polymer-functionalized silicon nanocrystals and alkanoic acid-functionalized silicon nanocrystals by the nitro-containing compounds. The detector and method are non-toxic, portable, rapid and straightforward and therefore are amenable for convenient on-site detection of nitro-containing compounds. | 07-09-2015 |
20150150239 | CRYOPRESERVATION OF ARTICULAR CARTILAGE - The invention relates generally to methods and compositions for the cryopreservation and/or vitrification of tissue including articular cartilage and the preparation of said tissue for clinical or research use, including but not limited to joint replacement and the treatment and prevention of osteoarthritis. | 06-04-2015 |
20150118263 | GLYCOENGINEERED OUTER MEMBRANE VESICLES AND USE THEREOF AS VACCINES - The present application relates to glycoengineered outer membrane vesicles obtained from recombinant, gram-negaetive bacteria comprising hetereologous DNA encoding an enzyme or enzymes that produce a heterologous glycan that replaces all or a portion of the naturally-occurring O antigen in the lipopolysaccharides of the bacteria. Also provided by the present application are immunogenic compositions and vaccines prepared from the glycoengineered outer membrane vesicles expressing the heterologous glycans at their surface. | 04-30-2015 |
20150072446 | METHODS FOR TAILORING ELECTRODE WORK FUNCTION USING INTERFACIAL MODIFIERS FOR USE IN ORGANIC ELECTRONICS - The present invention is directed to methods for tailoring the work function of electrodes in organic electronics using interfacial modifiers comprising functionalized semiconducting polymers and/or small molecules. | 03-12-2015 |
20150060771 | ATOMISTIC QUANTUM DOTS - A quantum device is provided that includes controllably quantum mechanically coupled dangling bonds extending from a surface of a semiconductor material. Each of the controllably quantum mechanically coupled dangling bonds has a separation of at least one atom of the semiconductor material. At least one electrode is provided for selectively modifying an electronic state of the controllably quantum mechanically coupled dangling bonds. By providing at least one additional electron within the controllably quantum mechanically coupled dangling bonds with the proviso that there exists at least one unoccupied dangling bond for each one additional electron present, the inventive device is operable at least to 293 degrees Kelvin and is largely immune to stray electrostatic perturbations. Room temperature operable quantum cellular automata and qubits are constructed thereform. | 03-05-2015 |
20150024958 | METHOD OF QUANTIFYING PEPTIDE-DERIVATIVE LIBRARIES USING PHAGE DISPLAY - The present application provides a method of quantifying an amount of a derivatized peptide displayed on a phage by phage display, the method comprising: providing a phage containing the target peptide thereon; reacting the phage containing the target peptide with a first reagent to derivatize the target peptide to form a derivatized peptide, reacting the derivatized peptide with a capture agent comprising a detection marker, thereby incorporating the detection marker within the derivatized peptide; and determining an amount of the detection marker, thereby quantifying the amount of the derivatized peptide displayed on the phage. A kit comprising a capture agent comprising a detection marker for quantifying the phage displayed derivatized peptides is also provided. | 01-22-2015 |
20150010582 | USE OF PDGFR-ALPHA AS DIAGNOSTIC MARKER FOR PAPILLARY THYROID CANCER - Provided herein are methods for identifying a subject with an increased likelihood of developing or having metastatic papillary thyroid cancer (PTC), or a subject with an increased likelihood of developing or having recurrent PTC, and the treatment of such a subject. | 01-08-2015 |
20140328006 | CARBON NANOSHEETS - There is disclosed a combined hydrothermal and activation process that uses hemp bast fiber as the precursor to achieve graphene-like carbon nanosheets, a carbon nanosheet comprising carbonized crystalline cellulose, a carbon nanosheet formed by carbonizing crystalline cellulose, a capacitative structure comprises interconnected carbon nanosheets of carbonized crystalline cellulose, a method of forming a nanosheet comprising carbonizing crystalline cellulose to create carbonized crystalline cellulose. The interconnected two-dimensional carbon nanosheets also contain very high levels of mesoporosity. | 11-06-2014 |
20140316117 | POLYMERS AND PLASTICS DERIVED FROM ANIMAL PROTEINS - The invention is directed to a method for preparing a polymer derived from an animal protein, such as in a feedstock derived from animal by-products. The method involves hydrolyzing proteins present in a feedstock to obtain hydrolyzed proteins, wherein hydrolysis is conducted under conditions sufficient to digest the proteins and destroy pathogens; extracting a protein fraction from the hydrolyzed proteins; and treating the protein fraction with a crosslinking reagent to form the polymer. The crosslinking reagents may include epoxies. The polymer may be further processed to form a thermoset plastic. The polymer may be used as an adhesive, or in the preparation of a natural fiber composite material. | 10-23-2014 |
20140289908 | GENE COMBINATIONS FOR PRODUCING PUNICIC ACID IN TRANSGENIC PLANTS - Transgenic plants with enhanced punicic acid accumulation result from over-expression of PgFADX and PgFAD2, and optionally, one or more of PgDGAT1, PgDGAT2, and PgPDAT1. The invention also relates to novel isolated | 09-25-2014 |
20140287991 | Hepatitis B Virus-Binding Polypeptides and Methods of Use Thereof - The present invention provides non-naturally occurring polypeptides that specifically bind hepatitis B virus (HBV) DNA; and polynucleotides encoding the polypeptides. The present invention further provides methods of detecting HBV DNA; methods of detecting a covalently closed circular DNA (cccDNA) form of HBV; and methods for treating HBV infection. | 09-25-2014 |
20140249051 | METHOD AND SYSTEM FOR ABO ANTIBODY DETECTION AND CHARACTERIZATION - The present application discloses a system and method for ABO antibody detection and characterization that can provide an alternative means for assessment and management of ABO-incompatible and ABO-compatible transplants. The method and system comprises determining an anti-ABO blood group antigen subtype antibody profile of a subject using a biological sample from the subject. The method and system can be used to evaluate the suitability of a donor blood or tissue product for a recipient subject by comparing the determined anti-ABO antigen subtype antibody profile of the recipient subject with the ABO histo-blood group or ABO histo-blood subgroup of a donor blood or tissue product. In order to define the subject's ABO histo-blood subgroup, the determined antibody profile is compared to known ABO histo-blood group antigen subtype profiles and/or known anti-ABO antigen subtype antibody profiles for ABO histo-blood subgroups to identify the ABO histo-blood subgroup of the subject. Profiles can be established by applying a sample to an array of surface-bound ABO antigens selected from the group of type I to type VI antigens of each blood group A, B or H. | 09-04-2014 |
20140235884 | METHOD OF PREPARING SILICON NANOCRYSTALS - The present application includes a method of preparing silicon nanocrystals (Si-NCs) comprising combining silica particles with magnesium and heating said combination under conditions to form Si-NCs, wherein the silica particles are obtained using sol gel chemistry. | 08-21-2014 |
20140234257 | Oncolytic Viruses and Methods for Treating Neoplastic Disorders - The disclosure provides mutant ribonucleotide reductase strains of poxviruses including for example vaccinia viruses. The disclosure also provides methods and for the use of these mutant ribonucleotide reductase strains of vaccinia viruses in oncolytic virotherapy. | 08-21-2014 |
20140231379 | METHOD OF FABRICATING NANOTIPS WITH CONTROLLED PROFILE - A nanotip, is fabricated by modifying a precursor nanotip having an apex and a shank by applying an electric field in the presence of a reactive gas to perform field-assisted etching wherein atoms are preferentially removed from the shank by chemical interaction with the reactive gas, and controlling the reactive gas pressure and/or tip voltage to vary the electric field so as to promote field evaporation of apex atoms during fabrication of the nanotip and thereby control the overall profile of the resulting nano-tip. The method permits shaping of the overall tip profile. | 08-21-2014 |
20140221296 | METHODS OF PHOSVITIN EXTRACTION AND PHOSPHOPEPTIDE PREPARATION FROM EGG YOLK - The invention is directed to methods for extracting phosvitin from egg yolk involving contacting the egg yolk or egg yolk protein granules with a solution having a salt concentration of about 10% to form a mixture; optionally, heating the mixture; adjusting the pH of the mixture to separate phosvitin from other proteins; recovering the phosvitin. The phosvitin extract may be dephosphorylated and hydrolyzed to produce phosvitin phosphopeptides. | 08-07-2014 |
20140220340 | Branched Nanowires and Method of Fabrication - A new set of branched nanowire or nanotree structures and their fabrication process. Some structures have one or more of the following distinctions from other branched nanowires: (1) the trunk and branch diameter and branching number density can be changed along the trunk's length; (2) the branch's azimuthal direction can be controlled along the trunk's length; (3) the branch's diameter can be modulated along its length; (4) the crystal orientation and branches of the ensemble of nanowires can be aligned on a non-epitaxially matched substrate. The structures are made by a geometrically controlled kinetic growth method. | 08-07-2014 |
20140170150 | N-LINKED GLYCAN COMPOUNDS - An isolated or purified compound is provided, comprising A-GlcNAc[GlcNAc]-GalNAc-GalNAc-QuiNAc4NAc, wherein A is GlcNAc or Glc. There is further provided a vaccine based on such compound, having particular use to treat or prevent an infection caused by a | 06-19-2014 |
20140163225 | CATALYSTS AND PROCESSES FOR THE HYDROGENATION OF AMIDES - There is provided a process for the reduction of one or more amide moieties in a compound comprising contacting the compound with hydrogen gas and a transition metal catalyst in the presence or absence of a base under conditions for the reduction an amide bond. The presently described processes can be performed at low catalyst loading using relatively mild temperature and pressures, and optionally, in the presence or absence of a base or high catalyst loadings using low temperatures and pressures and high loadings of base to effect dynamic kinetic resolution of achiral amides. | 06-12-2014 |
20140154516 | ADHESIVES DERIVED FROM AGRICULTURAL PROTEINS - The invention is directed to adhesives derived from animal or plant proteins, particularly canola and spent hen proteins. The adhesives are prepared by extracting the proteins by pH shifting; and either treating the extracted proteins with urea or sodium dodecyl sulfate, or polymerizing the proteins to form a protein-polymer conjugate. The invention is also directed to a wood based product comprising pieces of wood based material joined or consolidated with the adhesives. | 06-05-2014 |
20140148356 | APPARATUS AND METHOD FOR SINGLE-CYCLE SELECTION OF APTAMERS - A method for single-cycle selection of aptamers is provided. More specifically, a method comprising single-cycle selection of aptamers for proteins blotted on a membrane is provided. In some embodiments, the present methods can comprise a deoxyribonuclease I (DNase I) mediated aptamers selection strategy that may be capable of isolating strong binding aptamers for target proteins from a crude protein extract. Aptamers selected using the present method are further provided. More specifically, the presently selected aptamers may be thermally stable, modifiable and easily produced through single-cycle synthesis process. The present aptamers may provide unique affinity reagents for use in diagnosing and detecting infectious disease (for example Hepatitis B), for research and biochemical studies (e.g. into molecular mechanisms). Further, the present aptamers may be utilized to develop unique assays or kits for clinical application, such as monitoring disease treatment and outcome. | 05-29-2014 |
20140117809 | CMUT Array - Novel CMUT architectures are provided permitting independent addressability of both top and bottom CMUT electrodes. CMUT top electrodes are connected in strips along the x-direction, while CMUT bottom electrodes are connected in strips along the y-direction. In an embodiment, 3D imaging can be performed with an N×N 2D array using only N transmit channels and N receive channels. | 05-01-2014 |
20140106967 | AUXIN PLANT GROWTH REGULATORS - Compositions and methods for enhancing plant growth in a flowering plant having an auxin response pathway by applying an effective amount of a composition comprising an auxin or auxin analog to the plant, or a portion thereof, or a locus thereof, at or before an early reproductive stage of the plant. The enhanced plant growth may ameliorate the effects of abiotic stress and/or improve fruit or seed yield. | 04-17-2014 |
20140077662 | PIEZOELECTRIC APPARATUS FOR HARVESTING ENERGY FOR PORTABLE ELECTRONICS AND METHOD FOR MANUFACTURING SAME - This disclosure presents an advanced design of an energy harvester that utilizes a piezoelectric element to convert vibration to electricity. The advanced design is based on a fixed-fixed folded beam. An aqua regia wet etching and PZT sol-gel deposition/patterning processes can be used to manufacture the energy harvester. | 03-20-2014 |
20140060383 | THERMOPLASTICS FROM POULTRY FEATHERS - The invention is directed to thermoplastics derived from feathers. The thermoplastics are prepared by blending whole feathers or portions thereof with a plasticizer in an amount ranging from about 20 wt to about 40 wt % and a reducing agent in an amount ranging from about 1 wt % to about 5 wt % to form a mixture; and either extruding the mixture to form an article, or pressing the mixture into a film at an elevated temperature. | 03-06-2014 |
20140054503 | APPARATUS AND METHOD FOR UPGRADING COAL - A method of upgrading coal is disclosed, the method comprising: subjecting the coal to a hydrothermal dewatering process at a temperature and a pressure above ambient conditions to produce dewatered coal; removing ash tailings from the dewatered coal to produced reduced ash dewatered coal; and producing a coal water slurry with the reduced ash dewatered coal. An apparatus for upgrading coal is also disclosed, the apparatus comprising: a hydrothermal dewatering reactor connected to receive coal and output dewatered coal; an ash separator connected to receive dewatered coal from the hydrothermal dewatering reactor and output reduced ash dewatered coal; a slurrifier connected to receive reduced ash dewatered coal from the ash separator and output a coal water slurry. | 02-27-2014 |
20140029710 | PRODUCTION OF TECHNETIUM FROM A MOLYBDENUM METAL TARGET - Recycling of isotopically enriched molybdenum metal targets that are suitable for the large scale cyclotron production of | 01-30-2014 |
20140013205 | METHODS FOR MATCHING XML DOCUMENTS - Methods, systems, and devices related to determining differences between XML documents. Two XML documents to be compared are first each decomposed into ordered labelled trees. Sets of operations which convert one tree into the other tree are then determined and a cost function is applied to each set of operations. The set of operations with the lowest cost is then selected. The cost function uses an affine-cost policy which adjusts a cost of each operation based a context in which the operation is applied. | 01-09-2014 |
20140011205 | LEUKOCYTE ACTIVATION AND METHODS OF USE THEREOF - Described herein are compositions, methods and/or kits for determining the likelihood of a pregnant subject delivering at term, or developing a disorder associated with pregnancy. These compositions, methods and/or kits feature the measurement of the chemotactic activity of peripheral leukocytes, the measurement of ccl2 mRNA expression or the measurement of Fp or Otr protein expression. | 01-09-2014 |
20130334218 | MICROWAVE HEATING WITH SUSCEPTOR - There is disclosed a method of heating a wafer for bonding, the method comprising adding a patterned susceptor close to a wafer interface, and applying microwave energy to the patterned susceptor. There is also disclosed an electrically conductive film, in direct contact with a relatively non-conductive substrate (preferably a thermoplastic) and made of individual electrically isolated elements (features) with a maximum dimension less than ¼ the wavelength used in the microwave, and minimum dimension greater than 100 um in the plane of the film. The film and substrate is selectively heated by resistive loss caused by dissipated energy from microwave radiation. | 12-19-2013 |
20130295099 | N-LINKEDGLYCAN COMPOUNDS - An isolated or purified compound is provided, comprising A-GlcNAc[GlcNAc]-GalNAc-GalNAc-QuiNAc4NAc, wherein A is GlcNAc or Glc. There is further provided a vaccine based on such compound, having particular use to treat or prevent an infection caused by a | 11-07-2013 |
20130289095 | SYNTHETIC LETHALITY IN CANCER - There is described herein compounds, compositions and methods for inducing synthetic lethality in a cancer cell(s). | 10-31-2013 |
20130276886 | POLYMER SOLAR CELLS AND FUNCTIONALIZED CONJUGATED POLYMERS - A functionalized conjugated polymer comprising alternating copolymer donor and acceptor units in which at least one of the donor and acceptor units comprises a linking group and a functional group attached to the linking group. The linking group may comprise an alkyl group. The functional group may comprise one or more carboxyl, halogen (such as fluorine and chlorine), hydroxyl, carbonate, imino, cyano, nitro, amine, and amide functional groups. More than one functional group may be present for each linking group. Not every copolymer unit need have a linked functional group. The linking group may be attached to either or both of the donor and acceptor units. The functional group may terminate the linking group. | 10-24-2013 |
20130274494 | POLYOL SYNTHESIS FROM FATTY ACIDS AND OILS - A method for preparing polyols from fatty acid substrates such as free fatty acids, alkyl esters of fatty acids, mono-glycerides, diglycerides, and triglycerides. The method comprises the steps of (a) epoxidizing an unsaturated fatty acid substrate and (b) hydroxylating the epoxidized fatty acid substrate with at least one diol to produce a polyol or a blend of polyols. The method may be varied to produce polyols with desired functionality, molecular weights, or viscosity. | 10-17-2013 |
20130265856 | THERMOACOUSTIC SENSOR - A close-proximity thermoacoustic sensor that can determine radiated ultrasound intensities by directly coupling a transducer via a coupling medium. The sensor captures the beam, converts the ultrasound power into heat, and indirectly measures the spatial average time average ultrasound intensity (I | 10-10-2013 |
20130245524 | KNEE ANKLE FOOT ORTHOSIS - A Knee-Ankle-Foot-Orthoses (KAFO) brace mechanically generates a knee extensor moment and allows for a flexed knee during STS, allowing for reduced upper body demand to be placed on the patient. An orthosis comprises a femoral brace and a tibial brace connected together with a pivot to form a knee joint between the femoral brace and the tibial brace, and a knee extension moment generator at the knee joint. Also, a foot brace may be connected to the tibial brace to form an ankle joint with an ankle plantar flexion moment generator disposed about the ankle joint. | 09-19-2013 |
20130239700 | PIEZORESISTIVE LOAD SENSOR - A three-axis load sensor utilizing four piezoresistive devices on a flexible silicon membrane is provided. The load sensor further includes a mesa disposed on the membrane substantially equidistant from the piezoresistive devices. A six-axis load cell is provided by placing a plurality of load sensors disposed on a substrate, the substrate configured to attach to an object wherein forces applied to the object can be measured and/or determined. The load sensors can be manufactured using bulk microfabrication techniques on a single crystal silicon wafer, and can detect normal and shear loading applied to the membrane. | 09-19-2013 |
20130228525 | TEMPERATURE SWITCHABLE POLYMERS FOR FINE COAL DEWATERING - A flocculating agent that comprises a complex of a metal salt and multiple strands of a temperature sensitive polymer. A process for separating coal fines from an aqueous liquid using a flocculent having a critical flocculation temperature, said critical flocculation temperature being the temperature below which flocculent is hydrophilic and forms floccules with fines and above which the flocculent is hydrophobic, which comprises adding to the aqueous liquid an effective amount of the flocculent at a temperature below the critical flocculent flocculation temperature of the flocculent to cause generation of floccules, said comprising at least a metal complex including a metal salt and a water soluble polymer, separating (for example filtering) floccules from the aqueous liquid, then heating the floccules to a temperature above the critical flocculation temperature of the flocculent to expel water from the floccules to create a solids and expelled water, and separating the expelled water from the solids. | 09-05-2013 |
20130211066 | COMPOUNDS USEFUL IN IMAGING AND THERAPY - Provided in the following specification are precursors or synthons that are useful for the synthesis of various arabinose based chemical and radiochemical derivatives of nitroimidazole-containing azomycin arabinosides, such as radioiodinated 1-#-D-(5-deoxy-5-[I*]-iodoarabinofuranosyl)-2-nitroimidazole (*IAZA), and radiofluorinated 1-#-D-(5-deoxy-5-[18F]-iodoarabinofuranosyl)-2-nitroimidazole (18FAZA). Such compounds are useful in imaging, therapy, or radiotherapy. Further, various syntheses of said precursors/synthons and the incorporation of said precursors/synthons into kits is provided. The precursors/synthons provided herein allow for an improved and facile manufacturing process for nitroimidazole-containing azomycin arabinosides. | 08-15-2013 |
20130210618 | KINETIC STABILIZATION OF MAGNESIUM HYDRIDE - A hydrogen absorbing and desorbing material formed by co-deposition of magnesium with a catalyst for the kinetic absorption and desorption of hydrogen. A hydrogen absorbing and desorbing material formed of an alloy of magnesium with a catalyst for the kinetic absorption and desorption of hydrogen in which the catalyst for the kinetic absorption and desorption of hydrogen forms a dispersed amorphous or nanocrystalline phase in the magnesium. A hydrogen absorbing and desorbing material having a catalytic surface formed by a process comprising the steps of depositing a layer of tantalum on the hydrogen absorbing and desorbing material and depositing a layer of palladium on the layer of tantalum. A hydrogen absorbing and desorbing material comprises a multilayer film having at least two layers of magnesium and at least two layers of catalyst for the kinetic absorption and desorption of hydrogen, in which the multilayer film comprises alternating layers of magnesium and catalyst. | 08-15-2013 |
20130205910 | NOVEL EMBEDDED 3D STRESS AND TEMPERATURE SENSOR UTILIZING SILICON DOPING MANIPULATION - A new approach for building a stress-sensing rosette capable of extracting the six stress components and the temperature is provided, and its feasibility is verified both analytically and experimentally. The approach can include varying the doping concentration of the sensing elements and utilizing the unique behaviour of the shear piezoresistive coefficient (π | 08-15-2013 |
20130178515 | PREDICTIVE MARKERS FOR TAXANE RESPONSIVENESS AND METHODS OF USE THEREOF - Taxanes are widely used in the treatment of breast cancer, although there are currently no validated predictive markers for taxane responsiveness. While the mechanism by which taxanes induce mitotic arrest is well documented, the signaling pathway that links mitotic arrest to cell death, is ill-defined. As described herein, the BH3-only protein Bad and Bik are prognostic indicators for overall survival after adjuvant taxane chemotherapy and a predictive marker for taxane responsiveness. | 07-11-2013 |
20130165333 | Methods and Systems for Preparing Irreversible Inhibitors of Protein Tyrosine Phosphatases - Described herein are the preparation and use of novel bromo-phosphonomethylphenylalanine amino acid derivatives (BrPmp) and BrPmp-containing peptides as specific, irreversible protein tyrosine phosphatase inhibitors, which are suitable for application in peptide synthesis. These derivatives are particularly advantageous since their synthesis is both easy and scalable, and they are suitable for peptide synthesis. The BrPmp derivatives described herein can be appropriately protected to allow for solid phase peptide synthesis (SPPS) and incorporation into peptides for preparation of protein tyrosine phosphatase inhibitors and inhibitor libraries. The peptides and peptide libraries can be used to identify new protein tyrosine phosphatase specific sequences and profile protein tyrosine phosphatase activity in cell lysates, diagnostic samples and biopsy samples. | 06-27-2013 |
20130160169 | FUNGAL DESATURASE AND ELONGASE GENES - The invention is directed to isolated polynucleotide and polypeptides of the CoD5, CoD6 and CoE6 genes from | 06-20-2013 |
20130157278 | SETTING OF MULTIPLE PRIMING OLIGONUCLEOTIDES FOR SOLID GEL AMPLIFICATION IN HYDROGELS - The present invention provides for a novel system and method for amplification and detection of nucleic acids within a microfluidic device wherein multiple nucleotides capable of priming PCR are present within the system and substantially sequestered within separate hydrogel posts therein. | 06-20-2013 |
20130150556 | DEAMIDATED BARLEY PROTEINS - The invention is directed to a method of producing deamidated barley proteins by extracting protein from barley using an alcohol or alkaline; treating the extracted protein with an alkaline or acidic solution for a sufficient time and temperature for partial deamidation; and recovering partially deamidated protein from the solution. The partially deamidated protein has improved functional properties with respect to solubility, and emulsifying and foaming properties at acidic and neutral pHs compared to those of a non-deamidated protein. | 06-13-2013 |
20130149709 | SOLID GEL AMPLIFICATION METHOD AND APPARATUS FOR GENOTYPING AND PATHOGEN DETECTION - The present invention provides for a novel system and method for amplification and detection of nucleic acids within a miniaturized device. | 06-13-2013 |
20130144369 | FLEXIBLE-BASE ELECTRODE ARRAY AND SURROGATE NEURAL TISSUE - A flexible-base electrode array for implantation within neural tissue, method of making the electrode array and use thereof, is provided. A surrogate neural tissue, method of making same and use thereof, is further provided. The use of the present flexible-base electrode array for implantation into the surrogate neural tissue for stimulation or recording neural activity, wherein the array is biocompatible with the surrogate tissue. | 06-06-2013 |
20130136860 | METHOD OF FABRICATING A CARBON NANOTUBE ARRAY - A method of fabricating carbon nanotube arrays (CNTA) on an oxide catalyst layer is disclosed. In one embodiment, the oxide catalyst is a metal oxide. The metal oxide may be deposited on a substrate used as a support. The CNTA is grown on the oxide catalyst layer under conditions promoting CNT growth. CNT growth is dependent on temperature, concentration of oxidizing molecules and carbon availability. One embodiment of the method comprises depositing an oxide catalyst layer on the substrate, heating the catalyst layer at certain rates to the target temperatures, adding oxidation molecules for the pretreatment of the oxide catalyst layer, and growing the array on the substrate. The oxide catalyst layer may comprise a group VIII element. | 05-30-2013 |
20130116428 | NOVEL POLY(ETHYLENE OXIDE)-BLOCK-POLY(ESTER) BLOCK COPOLYMERS - The present invention relates to micelle-forming poly(ethylene oxide)-block-poly(ester) block copolymers having reactive groups on the polyester block therein. The biodegradability of these copolymers and their biocompatibilities with a large number of bioactive agents make them suitable as carriers for various bioactive agents. The bioactive agents, such as DNA, RNA, oligonucleotide, protein, peptide, drug and the like, can be coupled to the reactive groups on the polyester block of the copolymer. | 05-09-2013 |
20130115596 | DNA POLYMORPHISMS AS MOLECULAR MARKERS IN CATTLE - A method of predicting the phenotype of cattle through the analysis of one or more single nucleotide polymorphisms (SNPs) is described. More particularly, a method for predicting cattle temperament and behavior through the analysis of one or more single nucleotide polymorphisms (SNPs) mapped at specific regions of the bovine genome is described. | 05-09-2013 |
20130101849 | Supercritical Fluid Treatment of High Molecular Weight Biopolymers - Micro- and nano-sized particles, agglomerates and fibers are generated from high molecular weight water-soluble biopolymers applying supercritical fluid technology. A method of producing micro- or nanoparticles from an aqueous solution of a high molecular weight biopolymer includes the step of spraying the aqueous solution together with a mixture of a compressible gas and a water-soluble co-solvent/antisolvent into a pressurized chamber. The method may be adapted to impregnate the micro- or nanoparticles with a bioactive material. A method for microencapsulating a bioactive material with a biopolymer is also provided. | 04-25-2013 |
20130078616 | METHOD AND SYSTEM FOR AMPLIFICATION OF NUCLEIC ACIDS IN MICROFLUIDIC VOLUME HYDROGELS - The present invention provides for a novel method and system for amplification of nucleic acids within a hydrogel of microfluidic volume using a hydrocarbon wax as a support substrate. | 03-28-2013 |
20130078184 | FLUORINATED FRUCTOSE DERIVATIVES FOR PET IMAGING - The present invention is directed to fructose-based radiopharmaceuticals, pharmaceutical compositions comprising same, precursors and methods for preparing same, and methods of using same for diagnostic imaging of cancer cells and non-imaging tracer studies. | 03-28-2013 |
20130065320 | METHODS FOR THE ASSESSMENT OF COLORECTAL CANCER AND COLORECTAL POLYPS BY MEASUREMENT OF METABOLITES IN URINE - Methods for the diagnosis of CRC, colorectal polyps in general and adenomatous polyps in particular by measurement of metabolites in urine are described. In some embodiments, certain metabolites are identified as being elevated or reduced in concentration or quantity in subjects with CRC and/or colorectal polyps as compared with subjects without CRC or colorectal polyps. The measurement of these metabolites in urine can indicate the presence of CRC or colorectal polyps in general or adanomatous polyps in particular in a subject. | 03-14-2013 |
20130065050 | PRODUCTION OF DECORATED CARBON NANOTUBES - A method of dispersing a metal or metal oxide within a CNT or CNT array, comprising exposing the CNT or CNT array to a solution containing a metal compound in a non-aqueous liquid; and removing the non-aqueous liquid from the CNT or CNT array. Nanoparticles were homogenously deposited within millimeter-long carbon nanotube array (CNTA). After modified with nanoparticles, CNTA changes from hydrophobic to hydrophilic. The hydrophilic composite electrodes present ideal capacitive behavior with high reversibility. The novel, nano-architectured composite demonstrates strong promise for high-performance thick and compact electrochemical supercapacitors. | 03-14-2013 |
20130059121 | NANOCRYSTALLINE SILICON IN SIO2 COMPOSITE AND FREESTANDING SILICON NANOPARTICLES - A nanocrystalline-Si/SiO | 03-07-2013 |
20130053576 | HETEROGENEOUS RHODIUM METAL CATALYSTS - Novel polymeric rhodium catalysts having repeating subunits of Formula (I), wherein R | 02-28-2013 |
20130034556 | FREE HEXASACCHARIDE ISOLATED FROM SEVERAL CAMPYLOBACTER SPECIES - An isolated or purified compound is provided, comprising A-GlcNAc[GlcNAc]-GalNAc-GalNAc-QuiNAc4NAc, wherein A is GlcNAc or Glc. There is further provided a vaccine based on such compound, having particular use to treat or prevent an infection caused by a | 02-07-2013 |
20130014644 | SILICATE MATERIALS, METHOD FOR THEIR MANUFACTURE, AND METHOD FOR USING SUCH SILICATE MATERIALS FOR ADSORPTIVE FLUID SEPARATIONS - Embodiments of crystalline, titanium silicate molecular sieves are described having a formula representing mole ratios of oxides of | 01-17-2013 |
20120316370 | METHODS FOR PRODUCING FUELS AND SOLVENTS SUBSTANTIALLY FREE OF FATTY ACIDS - Described herein are methods for producing fuels and solvents from fatty acid re-extraction sources. In general, the pyrolysis products of fatty acids are extracted in order to remove residual fatty acids and produce very pure hydrocarbon compositions composed of alkanes and alkenes. The fatty acids removed from the extraction step can be further pyrolyzed to produce additional hydrocarbons or, in the alternative, the fatty acids can be isolated and used in other applications. Also disclosed herein are fuels and solvents produced by the methods described herein. | 12-13-2012 |
20120294793 | PRODUCTION OF GRAPHENE SHEETS AND RIBBONS - A method comprises: physically attaching one or more of metals, metal compounds or oxides to walls of carbon nanotubes; treating the metals, metal compounds or oxides to bond the metals, metal compounds, or oxides chemically to the carbon nanotubes; removing the metals, metal compounds or oxides from the walls of the carbon nanotubes resulting in defected carbon nanotubes; and unzipping the defected carbon nanotubes into graphene sheets or ribbons. | 11-22-2012 |
20120270787 | COMPOUNDS HAVING PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF - Described herein are compositions having a peptide sequence that includes at least one bone targeting moiety, wherein the bone targeting moiety is bonded to the peptide sequence by a linker, wherein the peptide sequence is calcitonin, and wherein the composition is neutral or a pharmaceutically acceptable salt or ester thereof. In one aspect, calcitonin inhibits or slows osteoclast mediated resorptive bone loss. The compounds described herein can be used in a number of therapeutic applications including treating or preventing conditions associated with bone loss, which include, but are not limited to, osteoporosis, Paget's disease, osteolytic tumors, Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Osteoarthritis, osteopenia, and hypercalcemia. Also described herein are the methods of making these compositions that prevent or treat conditions associated with bone loss and methods of preventing bone fractures. | 10-25-2012 |
20120259609 | AUTOMATED, OBJECTIVE AND OPTIMIZED FEATURE SELECTION IN CHEMOMETRIC MODELING (CLUSTER RESOLUTION) - A novel metric, termed cluster resolution, which compares the separation of clusters of data points while simultaneously considering the shapes of the clusters and their relative orientations. This metric, in conjunction with an objective variable ranking metric, allows for the fully-automated determination of the optimal number of variables to be included in a chemometric model of a system. Cluster resolution is based upon considering the minimum distance between (or the extent of overlap of) confidence ellipses constructed around clusters of points representing different classes of objects. In one implementation, PCA was used to classify samples of gasoline based upon their octane rating. The entire GC-MS chromatogram of each sample comprising over 2×10 | 10-11-2012 |
20120255066 | TRANSGENIC EXPRESSION OF ACYL-CO-A BINDING PROTEINS IN PLANTS - Disclosed are methods for modification of fatty acid composition and/or seed oil content in plants. In particular are methods to over-express acyl-CoA binding proteins (ACBPs) within the cells of developing seeds are provided. Over-expressing ACBPs under the control of a seed preferred promoter increases polyunsaturated fatty acid (PUFA) levels as compared to wild-type controls. | 10-04-2012 |
20120254251 | SYSTEMS AND METHODS FOR EFFICIENT TOP-k APPROXIMATE SUBTREE MATCHING - Systems and method for searching for approximate matches in a database of documents represented by a tree structure. A fast solution to the Top-k Approximate Subtree Matching Problem involves determining candidate subtrees which will be considered as possible matches to a query also represented by a tree structure. Once these candidate subtrees are found, a tree edit distance between each candidate subtree and the query tree is calculated. The results are then sorted to find those with the lowest tree edit distance. | 10-04-2012 |
20120165227 | COMPOUNDS AND METHODS FOR DETECTION AND QUANTIFICATION OF CARBOXYLIC ACIDS - The present disclosure includes compounds of Formula I: wherein R | 06-28-2012 |
20120156678 | BINDING-INDUCED HAIRPIN DETECTION SYSTEM - This application relates to a binding-induced hairpin detection system comprising: a. a first probe comprising a targeting molecule and an oligonucleotide that has a free end and an end attached to the targeting molecule; and b. a second probe comprising a targeting molecule and an oligonucleotide that has an end attached to the targeting molecule and a free end comprising a nucleotide sequence that is complementary to a nucleotide sequence at or near the free end of the oligonucleotide of the first probe; wherein upon binding of the targeting molecule to a target molecule, the free end of the oligonucleotide of the second probe hybridizes at or near the free end of the oligonucleotide of the first probe forming a hairpin stem, the non-hybridized portions of the first and second probes together with the target molecule bound thereto forming a hairpin loop, thereby providing a binding-induced hairpin. | 06-21-2012 |
20120144999 | TITANOSILICATE MOLECULAR SIEVE SUPPORTED METALLIC NANODOTS AND METHODS OF USE TO ADSORB NOBLE GASES - A metal nanodot material is formed by ion-exchange with an ETS zeolite, followed by activation to form metallic nanodots. The nanodot may be formed from silver, nickel, copper, gold or a platinum group metal. | 06-14-2012 |
20120142721 | SMALL MOLECULE INHIBITORS OF POLYNUCLEOTIDE KINASE/PHOSPHATASE, POLY(ADP-RIBOSE) POLYMERASE AND USES THEREOF - The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions. | 06-07-2012 |
20120136185 | METHODS FOR PRODUCING FUELS AND SOLVENTS - Described herein are methods for producing fuels and solvents from fatty acid resources. Also disclosed herein are fuels and solvents produced by the methods described herein. | 05-31-2012 |
20120135392 | ULTRASOUND STIMULATION DEVICES AND TECHNIQUES - Ultrasound stimulation devices and related techniques are disclosed. An ultrasound transducer for generating ultrasound energy is carried by a transducer housing that seals the transducer and may also include a positioning element for positioning the transducer proximate an application area to which generated ultrasound energy is to be applied. The transducer housing may also carry such components as a battery, a wireless receiver, and a controller. The same housing or a separate sensor housing may include an ultrasound sensor that provides feedback to the ultrasound transducer or its controller, illustratively through a wireless transmitter. | 05-31-2012 |
20120115208 | MODULAR METHOD FOR RAPID ASSEMBLY OF DNA - The invention is directed to methods, kits and compositions using specially designed nucleic acid components for efficient assembly of a DNA construct. The method involves a) incubating a support with a first form of nucleic acid components under conditions to form support-bound nucleic acid component complexes; b) removing unbound first form nucleic acid components; c) incubating the support-bound first form nucleic acid component complexes with a second form of nucleic acid components under conditions to anneal and link the second form to the first form; d) removing unbound second form nucleic acid components; e) repeating steps c) and d) until the DNA construct is generated; and f) eluting the DNA construct from the support. The first and second forms of the nucleic acid component comprise sticky ends such that each form cannot link to itself but can link to each other to form an alternating head to tail sequence. | 05-10-2012 |
20120096924 | PARTICLE CLASSIFIER - A new installment classifies particles by their aerodynamic size This installment produces a truly monodisperse aerosol, and can produce very narrow distributions over a wide range of sizes Particles suspended in a fluid are classified by supplying particles into suspension in a carrier flow of a fluid and providing an acceleration to the flow at an angle to the velocity of the flow to cause the particles to follow trajectories determined by the acceleration and drag on the particles caused by the fluid The particles are then classified according to their trajectories The installment has a flow channel and a source of particles to supply particles into suspension in a carrier fluid in the flow channel A drive is connected to the flow channel at an angle to the flow of fluid through the carrier flow channel, and a classification system classifies the suspended particles according to their trajectories | 04-26-2012 |
20120083459 | USE OF GANGLIOSIDE TO DECREASE PROPAGATION OF MALIGNANT PROSTATE CELLS - Uses of exogenous ganglioside to inhibit the propagation of prostate cancer cells are provided. Gangliosides regulate many cellular processes including cell death. The present disclosure assesses the role of ganglioside in prostate cell growth. Malignant prostate (PC-3) and control (RWPE-1) cells can be cultured with or without ganglioside treatment. Cells can be assayed for differences in cell growth. Supplementation with ganglioside (GD3) can decrease growth of PC-3 cells by 30% compared to controls (p<0.01). Ganglioside can have therapeutic benefit in prostate cancer as demonstrated by decreased growth of malignant PC-3 cells. | 04-05-2012 |
20120060236 | AUXIN RECEPTORS - The invention is directed to isolated polynucleotide and polypeptides of the PsAFB2 and PsAFB6 genes from | 03-08-2012 |
20120059287 | ULTRASOUND STIMULATION DEVICES AND TECHNIQUES - Ultrasound stimulation devices and related techniques are disclosed. An ultrasound transducer for generating ultrasound energy is carried by a transducer housing that seals the transducer and may also include a positioning element for positioning the transducer proximate an application area to which generated ultrasound energy is to be applied. The transducer housing may also carry such components as a battery, a wireless receiver, and a controller. The same housing or a separate sensor housing may include an ultrasound sensor that provides feedback to the ultrasound transducer or its controller, illustratively through a wireless transmitter. | 03-08-2012 |
20120011624 | MICRO/NANO DEVICES FABRICATED FROM CU-HF THIN FILMS - An all-metal microdevice or nanodevice such as an atomic force microscope probe is manufactured from a copper-hafnium alloy thin film having an x-ray amorphous microstructure. | 01-12-2012 |
20120004219 | Method of Inhibition of Respiratory Depression Using Positive Allosteric AMPA Receptor Modulators - The invention is directed to a method for alleviating respiratory depression in a subject as a result of disease of pharmacological agents such as opiates, opioids or barbiturates. The invention also discloses pharmaceutical compositions for use with the method, the composition containing in combination, an analgesic, anaesthetic, or a sedative and a positive allosteric AMPA receptor modulator in an amount sufficient to reduce or inhibit respiratory depression caused by the analgesic, anaesthetic, or sedative. | 01-05-2012 |
20110312485 | METHOD FOR PREPARATION OF ACTIVATED CARBON - A method of preparing activated carbon, is disclosed, comprising: exposing carbonaceous material to microwave radiation in the presence of water to produce activated carbon. | 12-22-2011 |
20110278058 | NANOMATERIAL COMPOSITES AND METHODS OF MAKING - There is an electromagnetic interference shield and methods of constructing an electromagnetic interference shield. An electromagnetic interference shield has a network of conductive nanowires dispersed in a matrix material. The conductive nanowires form a segregated network. The segregated network may be a honeycomb network In a method for constructing an electromagnetic interference shield, a composite of conductive nanowires and matrix material is produced. Pockets of matrix material are formed within the composite of nanowires and matrix material. The pockets of matrix material may be formed by precipitation of the matrix material from a solvent or through dry-mixing of the composite with a second matrix material. | 11-17-2011 |
20110259076 | APPARATUS AND METHOD FOR ASSESSING PERCUTANEOUS IMPLANT INTEGRITY - Provided is an apparatus for assessing interface integrity between a medium and an implant. A first signal is translated from a motion of an impact body during impact with an abutment connected to the implant. In some embodiments, the first signal is filtered using a zero phase shift filter and then used for assessing the interface integrity. Since no phase shift is introduced, the interface integrity is accurately assessed. In another embodiment, the apparatus maintains a system model for impacting the impact body against the abutment. The apparatus analytically determines an interface property by applying a system property that has been determined to the system model. An accurate system model allows for an accurate assessment. According to another broad aspect, there is provided a method of conducting the impact test. According to the method, a person ensures that the impact body impacts against a consistent portion of the abutment. | 10-27-2011 |
20110243980 | METHODS AND SYSTEMS FOR O-GLYCOSYLATING PROTEINS - Described herein are methods and systems for O-glycosylating proteins in vivo or in vitro in any prokaryotic organism. In these methods and systems, DNA comprising a gene that produces a PglL-like oligosaccharyltransferase and DNA comprising a gene that produces a protein to be O-glycosylated are used. The PglL-like oligosaccharyltransferase facilitates the covalent attachment of the glycan to the protein to produce the O-glycosylated protein. The methods and systems described herein provide an approach for the design and production of new vaccines and therapeutic agents for the treatment of various diseases. | 10-06-2011 |
20110219478 | RECOMBINANT ANTIBODIES TO SCLEROTINIA ANTIGENS - The invention is directed to recombinant antibodies which bind to | 09-08-2011 |
20110212384 | ANODE CATALYSTS FOR FUEL CELL MEMBRANE REACTORS - Anode catalysts for conversion of hydrocarbon feeds in solid oxide fuel cell membrane reactors. An anode catalyst may be a mixture of a metal with a metal oxide, for example a mixture of copper or copper-nickel alloy or copper-cobalt alloy with Cr | 09-01-2011 |
20110206905 | METHOD FOR FORMING A BLOCK COPOLYMER PATTERN - A method for forming a block copolymer pattern on a substrate, wherein the areal density of nanostructures in the pattern is increased by increasing the thickness of the block copolymer film that is applied to the substrate. | 08-25-2011 |
20110195342 | SOLID OXIDE FUEL CELL REACTOR - An integral ceramic membrane for a fuel cell is provided, with a non-porous layer and porous layers both formed of proton conducting material. The proton-conducting material may be a compound or mixture of compounds of the formula X1-X2-O | 08-11-2011 |
20110174498 | HYDROCARBON RECOVERY PROCESS FOR FRACTURED RESERVOIRS - Steam-Over-Solvent Injection in Fractured Reservoirs (SOS-FR) is carried out by treating a fractured hydrocarbon bearing formation penetrated by a well with a first phase of injecting a formation compatible aqueous fluid into the fractured hydrocarbon bearing formation through the well, a second phase of injecting a hydrocarbon solvent into the fractured hydrocarbon bearing formation through the well and at least a third phase of repeating the first phase after the second phase. | 07-21-2011 |
20110128994 | ZONAL UWB RECEIVER AND METHOD - A novel ultra-wide bandwidth receiver structure dubbed the “zonal” receiver is proposed to detect time-hopping ultra-wide bandwidth signals in multiple access interference channels. The zonal receiver outperforms the conventional matched filter ultra-wide bandwidth receiver and the recently proposed soft-limiting ultra-wide bandwidth receiver when only MAI is present, or AWGN is negligible compared to MAI. In more practical mixed MAI-plus-AWGN environments, the zonal ultra-wide bandwidth receiver achieves better performance than the conventional matched filter ultra-wide bandwidth receiver, the recently proposed soft-limiting ultra-wide bandwidth receiver, and the recently proposed adaptive threshold soft-limiting ultra-wide bandwidth receiver. In multipath fading UWB channels, a new Rake receiver based on the zonal UWB receiver design has been proposed, this new Rake receiver can achieve better BER performance than the conventional matched filter based Rake receiver. | 06-02-2011 |
20110112604 | MITIGATION OF PRESSURE ULCERS USING ELECTRICAL STIMULATION - A method is provided for mitigating or preventing formation of pressure ulcers by transmitting an electrical stimulus sufficient to effect contraction of a loaded muscle, wherein the method comprises the steps of providing an electrical transmission for effecting contraction of the loaded muscle, transmitting sufficient electrical stimulation to the muscle to contract it for a predetermined period of time (the ON period), and ceasing transmission of the stimulus to the muscle for a predetermined period of muscle relaxation (the OFF period), whereby the predetermined period of relaxation is sufficient to cause sustained reoxygenation of the activated muscle. | 05-12-2011 |
20110071634 | End plate slider/distractor for posterior intervertebral device and method - A device and method for spreading apart adjacent vertebrae bodies for the safe insertion of an IBD into an IVD space said device designed for minimally invasive procedures and posterior or anterior approaches. | 03-24-2011 |
20110048945 | APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS - An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising; providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors. | 03-03-2011 |
20110041032 | Hybrid Message Decoders for LDPC Codes - Two hybrid message decoders for low-density parity-check (LDPC) codes are proposed. One decoder uses a posteriori probability ratio (APPR) and a posteriori probability difference (APPD), and the other decoder uses a logarithm a posteriori probability ratio (LAPPR) and a logarithm a posteriori probability difference (LAPPD) as hybrid message. Since the variable node and check node processing can be readily done using APPR and APPD, respectively, the proposed decoders have lower complexity than the conventional decoder that uses LAPPR only as a message. | 02-17-2011 |
20110035427 | PIXEL SENSOR CONVERTERS AND ASSOCIATED APPARATUS AND METHODS - There is described a pixel sensor converter for an image sensor array. In particular, a pixel sensor converter comprising: a delta-sigma converter comprising a modulator and a decimator. In some examples, the modulator is configured to be in communication with a detector, such as a photo-detector, and is configured to sample an analogue signal received from a detector at a particular sampling rate. The modulator is further configured to provide a bit stream of a particular bit rate. The provided bit stream corresponds to a sampled analogue signal. The decimator is in communication with the modulator, and is configured to receive and modify a bit stream provided from the modulator in order to provide a digital output signal. The provided digital output signal is representative of an analogue signal received at the modulator, but having a reduced bit rate than a corresponding bit stream provided by the modulator. | 02-10-2011 |
20110009492 | -PHENYLETHYLIDENEHYDRAZINE DERIVATIVES - The present invention provides new β-phenylethylidenehydrazine derivatives, processes for preparing them and their use as pharmaceutical compostions. The β-phenylethylidenehydrazine derivatives according to the invention generally correspond to the general formula: | 01-13-2011 |
20100326826 | APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS - An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising; providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors. | 12-30-2010 |
20100307238 | HUMIDITY SENSOR AND METHOD OF MANUFACTURING THE SAME - A humidity sensor comprising an insulating substrate, a moisture-sensitive layer, and at least a detection electrode contacting the moisture-sensitive layer, wherein the moisture-sensitive layer is a porous, photocatalytic metal oxide. | 12-09-2010 |
20100303916 | ENHANCED DRUG DELIVERY WITH ORIENTABLE PARTICLES - Small airway deposition of orientable drug particles in the lung due to interception is increased through alignment of these particles with an externally applied force such as a magnetic field. Drug particles in one embodiment are made magnetically responsive by loading them with magnetic nanoparticles. Elongated particles have a natural tendency to align parallel to the direction of flow through an airway, and therefore also parallel to airway walls; accordingly, alignment with a magnetic field to any other orientation increases interception, with a maximum increase for alignment perpendicular to airway walls. By positioning a magnetic field across a specific site within the lung, for example in the area of a tumor, the increase in deposition by interception allows localized targeting of inhaled drug particles to that area. | 12-02-2010 |
20100293674 | TRANSGENIC PLANTS EXPRESSING RECOMBINANT BARLEY ALANINE AMINOTRANSFERASE - Transgenic plants containing recombinant barley alanine aminotransferase are described. Also provided are methods for generating transgenic plants containing recombinant barley alanine aminotransferase. | 11-18-2010 |
20100269694 | Silicate Materials, Method For Their Manufacture, And Method For Using Such Silicate Materials For Adsorptive Fluid Separations - Embodiments of crystalline, titanium silicate molecular sieves are described having a formula representing mole ratios of oxides of n M | 10-28-2010 |
20100261889 | PROTEIN BASED FOAMING AGENTS AND METHODS OF MAKING THEREOF - Described herein are protein based foams and methods for making the same. The foams are derived from proteins that have been hydrolysed and chemically modified such that a foam produced from the protein has improved physical properties (e.g., reduced surface tension, increased foamability and foam stability). The protein is recovered from the animal rendering process as a component of an animal by-product (e.g., bloodmeal, bonemeal or meat). | 10-14-2010 |
20100240856 | Aromatic Ether-Containing Fluorene Monomers, Processes for their Preparation and Polymerization Thereof - Novel aromatic ether-containing monomers are described along with processes for their preparation and their polymerization into corresponding aromatic ether-containing polyfluorenes. These polyfluorenes exhibited stable blue-emission and therefore have application in polymer light-emitting devices. | 09-23-2010 |
20100207549 | LIGHT EMITTING SEMICONDUCTOR DIODE - Visible and infrared light sources on silicon that have several attractive properties with respect to integrated optics. First, the devices are operational at room temperature and strictly require no thermal processing in their synthesis (although low temperature annealing can be used to form Ohmic contacts). These devices could therefore be included at any stage of chip fabrication. The special ease of synthesis of these silicon LEDs enables simple fabrication of surface structures such as patterned emitters and photonic crystal surfaces that enhance light emission in the forward direction. The LEDs are color-switchable—by reversing the current one can switch from infrared emission to visible emission. The lifetime of the luminescence is much shorter than the standard carrier recombination time in silicon, suggesting direct modulation of the emitted light. | 08-19-2010 |
20100202734 | TAPERED WAVEGUIDE COUPLER AND SPECTROMETER - A method of forming a waveguide, the method comprising the steps of: forming a multilayer stack of light guiding layers; and delaminating the multilayer stack between at least two of the light guiding layers to form a waveguide between the light guiding layers; in which the patterned region has converging sides and the waveguide is tapered, the multilayer stack having increased transmissivity at a region corresponding to a selected thickness of the waveguide. A tapered waveguide is also disclosed, comprising: a multilayer stack of light guiding layers; the multilayer stack defining a channel between at least a first waveguiding layer and a second waveguiding layer; the channel having a diminishing thickness in a first direction; and at least one of the first waveguiding layer and the second waveguiding layer having a region of increased transmissivity adjacent a selected thickness of the core. Methods for the use of the tapered waveguide as an optical coupler or spectrometer are also disclosed. Methods for enhancing the optical resolution of the taper waveguide when operated as a spectrometer are also disclosed. | 08-12-2010 |
20100197960 | METHOD FOR THE ORGANOCATALYTIC ACTIVATION OF CARBOXYLIC ACIDS FOR CHEMICAL, REACTIONS USING ORTHOSUBSTITUTED ARYLBORONIC ACIDS - The present disclosure describes operationally simple methods for the low temperature, catalytic activation of carboxylic acids for organic reactions, in particular for direct amidation reactions with amines. The methods involve the use of orthosubstituted arylboromc acids of the formula (I), wherein the groups R | 08-05-2010 |
20100193737 | METHOD FOR PREPARING NANOCRYSTALLINE GERMANIUM IN GEO2 AND FREESTANDING GERMANIUM NANOPARTICLES - Methods for preparing nc-Ge/GeO | 08-05-2010 |
20100190460 | PRE-PROCESSOR FOR RECEIVER ANTENNA DIVERSITY - A dual-branch decorrelator receiver is provided in which decorrelation is performed with a simple addition and subtraction. The same receiver finds application in pre-processing signals that may not be correlated. | 07-29-2010 |
20100166695 | Multivalent Heterobifunctional Polymers And Methods Of Their Use - Designed herein are multivalent heterobifunctional polymers for binding to a biological target exhibiting biological activity and to an effector template which can affect the biological activity of the biological target or detect the presence of the biological target. The polymers comprise a plurality of pre-arranged heterobifunctional ligands connected thereto, and each heterobifunctional ligand comprises a first functionality capable of binding to the biological target, and a second functionality capable of binding to the effector template. The heterobifunctional ligands are pre-arranged on the polymer so as to form a ternary complex between the polymer, the biological target and the effector template. The polymers, methods and compositions described herein provide an approach for the design and production of new therapeutic agents as well as agents useful in a variety of non-therapeutic applications. | 07-01-2010 |
20100143820 | ANODE CATALYST AND METHODS OF MAKING AND USING THE SAME - The present disclosure relates to an ion conductive material useful as an anode catalyst comprising LaCrO | 06-10-2010 |
20100137206 | NOVEL LIGAND GUIDED BLOCK COPOLYMERS FOR TARGETED DRUG DELIVERY - This application relates to micelle-forming poly(ethylene oxide)-block-poly(ester) block copolymers having reactive groups on both the poly(ethylene oxide) block and the poly(ester) block therein. The biodegradability of these copolymers and their biocompatibilities with a large number of bioactive agents make them suitable as carriers for various bioactive agents. The bioactive agent, such as DNA, RNA, oligonucleotide, protein, peptide, drug and the like, can be coupled to the reactive groups on the polyester block of the copolymer. A variety of targeting moieties can be coupled to the reactive group on the poly(ethylene oxide) block for targeting the bioactive agent to a particular tissue. The application also relates to a composition and method of use thereof for delivering bioactive agents. | 06-03-2010 |
20100129383 | BIFUNCTIONAL FUSION MOLECULES FOR THE DELIVERY OF ANTIGENS TO PROFESSIONAL ANTIGEN-PRESENTING CELLS - The invention provides a bifunctional fusion molecule comprising: a first functional domain comprising a first immunoglobulin variable region, a second immunoglobulin variable region and a linker for connecting the first and second variable regions; a second functional domain comprising a moiety for binding to an antigenic agent; wherein the first and second functional domains are linked; and wherein the first functional domain specifically binds to a surface molecule of a professional antigen-presenting cell, and uses thereof. | 05-27-2010 |
20100113384 | BACTERIAL ENDOTOXIN FOR THE PREVENTION OF METABOLIC DISORDERS AND BACTERIAL INFECTIONS - The invention provides compositions and methods for preventing a metabolic disorder or bacterial infection in a subject, the composition comprising a bacterial endotoxin. | 05-06-2010 |
20100074307 | A P-ORDER METRIC UWB RECEIVER STRUCTURE WITH IMPROVED PERFORMANCE IN MULTIPLE ACCESS INTERFERENCE-PLUS-NOISE MULTIPATH CHANNELS - A UWB receiver dubbed the “p-order metric” receiver (p-omr) is proposed to detect the time-hopping ultra-wide bandwidth signal in multiple access interference channels. The receiver acquires a signal over a wireless channel, adaptively selects a shaping parameter, p, over time and generates a first set of partial statistics by, for each of a plurality N of observations per symbol, using the shaping parameter to modify the exponential order of the approximation of the noise plus multiple access interference probability density function, f(x), used in the receiver model. | 03-25-2010 |
20100069295 | NOVEL POLY(ETHYLENE OXIDE)-BLOCK-POLY(ESTER) BLOCK COPOLYMERS - The present invention relates to micelle-forming poly(ethylene oxide)-block-poly(ester) block copolymers having reactive groups on the polyester block therein. The biodegradability of these copolymers and their biocompatibilities with a large number of bioactive agents make them suitable as carriers for various bioactive agents. The bioactive agents, such as DNA, RNA, oligonucleotide, protein, peptide, drug and the like, can be coupled to the reactive groups on the polyester block of the copolymer. | 03-18-2010 |
20100061892 | MICROFLUIDIC DEVICE HAVING AN ARRAY OF SPOTS - A microfluidic spotting device has a first substrate patterned with an array of spots, a second substrate attached directly or indirectly to the first substrate, and channels formed at least partly in at least one of the first substrate and the second substrate, each channel having an inlet channel and an outlet channel. | 03-11-2010 |
20100021559 | ZEOLITE SUPPORTED METALLIC NANODOTS - A metal nanodot material is formed by ion-exchange with chabazite or a chabazite-like structure, followed by activation to form metallic nanodots. The nanodot may be formed from silver, nickel, copper, gold or a platinum group metal. | 01-28-2010 |
20100008401 | SYSTEM AND METHOD FOR RECEIVING TIME-HOPPING ULTRA-WIDE BANDWIDTHS SIGNALS - A novel receiver structure is proposed for detecting a time-hopping νltrat-wide bandwidth signal in the presence of multiple access interference. The proposed structure achieves better bit error rate performance than the conventional matched receiver when operating in multiple access interference. When operating in a multiple access interference-plus-Gaussian-noise environment, the receiver structure outperforms the conventional matched filter receiver for moderate to large values of signal-to-noise ratio. A receiver structure with adaptive limiting threshold is further proposed to ensure the performance of the soft-limiting receiver always meets or surpasses the performance of the conventional UWB receiver for all values of signal-to-noise ratio. | 01-14-2010 |
20090302208 | APPARATUS AND METHODS FOR LIQUID DROPLET DEPOSITION - A method of and an apparatus for generating droplets has a capillary tube mounted in a moveable member. The capillary tube is accelerated towards a plate, and then subject to rapid deceleration, e.g. by way of an impact, to promote separation of a droplet which is then deposited on the plate. The droplet can be entirely separated from the capillary tip before being deposited, or, for smaller droplets, the droplet merely extends from the capillary tip and is then drawn onto the plate by a wicking action. The plurality of capillary tubes can be mounted on the common support member to effect multiplexing of drops. | 12-10-2009 |
20090262869 | Decision-Feedback Detection for Block Differential Space-Time Modulation - Time variation on fading channels hinders accurate channel estimation in differential space-time modulation and deteriorates the performance. Decision-feedback differential detection is employed for block differential space-time modulation, and compared with conventional differential space-time modulation. It is observed that the proposed scheme does not suffer effective fading bandwidth expansion, as does the conventional scheme. An improved effective signal-to-noise ratio approach is proposed for analyzing the performance of the proposed scheme in time-varying flat Rayleigh fading. Theoretical analysis and simulations show the improved performance of the proposed scheme over the conventional scheme. | 10-22-2009 |
20090243635 | ANALYSIS OF THIN LIQUID FILMS - A novel microfluidic device has been developed to measure stability of thin liquid films of water in oil emulsions using electrochemical perturbation of interfaces. This new device can be utilized in rapid classification of de-emulsifiers used in petroleum industries. Although water/crude oil emulsions have been the primary focus of this research, this measurement platform can be used in other industries such as food, cosmetics and bio-engineering (bilayer lipid membranes) as well as environmental remediation of oil spills. The compact design of the device and replacement of the mechanical measurements such as pressure with electrical signal measurements contributes in substantial size reduction of the experimental platform so that it can be employed for onsite measurements in remote areas. | 10-01-2009 |
20090211632 | PHOTOVOLTAIC DEVICE BASED ON CONFORMAL COATING OF COLUMNAR STRUCTURES - A photovoltaic device, comprises a first electrode, an electron donor layer in electrical contact with the first electrode, an electron acceptor layer in contact with the electron donor layer across an interface having a shape defined by a columnar structure grown by oblique angle deposition, and a second electrode in electrical contact with the electron acceptor layer. | 08-27-2009 |
20090202655 | TITANOSILICATE MOLECULAR SIEVE SUPPORTED METALLIC NANODOTS AND METHODS OF USE TO ADSORB NOBLE GASES - A metal nanodot material is formed by ion-exchange with an ETS zeolite, followed by activation to form metallic nanodots. The nanodot may be formed from silver, nickel, copper, gold or a platinum group metal. | 08-13-2009 |
20090186859 | DIAZENIUMDIOLATED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, COMPOSITIONS THEREOF, AND RELATED METHODS - Disclosed are compounds that release nitric oxide, e.g., a compound of Formula (I) wherein R | 07-23-2009 |
20090170194 | TEAL FLUORESCENT PROTEINS - An isolated nucleic acid sequence encoding a non-oligomerizing Clavularia teal fluorescent protein (TFP) variant having a tyrosine-derived chromophore, and fragments and derivatives thereof. Also provided is a method for engineering the nucleic acid sequence, a vector comprising the nucleic acid sequence, a host cell comprising the vector, and use of the vector in a method for expressing the nucleic acid sequence. The present invention further provides an isolated nucleic acid, or mimetic or complement thereof, that hybridizes under stringent conditions to the nucleic acid sequence. Additionally, the present invention provides a non-oligomerizing TFP variant encoded by the nucleic acid sequence, as well as derivatives, fragments, and homologues thereof. Also provided is an antibody that specifically binds to the TFP variant. The present invention further provides a tandem dimer comprising two TFP dimers, operatively linked by a peptide linker. | 07-02-2009 |
20090103592 | MYRIAD FILTER DETECTOR FOR MULTIUSER COMMUNICATION - An adaptive receiver for multiple access communication, illustratively UWB multiple access communication, is provided. One embodiment of a detector is derived based on the finding that an symmetric alpha-stable model is more suitable for modeling the MAI in multiuser UWB systems than existing models. A myriad filter detector works better than all the known receiver structures proposed for statistical MAI cancellation. An intuitive expression for the tuning parameter K is provided which worked well in the examples considered. | 04-23-2009 |
20090092663 | Tumor-targeted drug delivery systems and uses thereof - The present invention relates to targeted delivery systems for delivering therapeutic agents to tumor. The invention further relates to methods of delivering a therapeutic agent to a tumor for the prevention and treatment of cancer by killing tumor cells and tumor-associated endothelial cells. In particular, the present invention provides a tumor-targeted drug delivery system comprising a NGR-containing molecule linked to a delivery vehicle encapsulating a therapeutic agent, preferably a drug, such as a cytotoxic agent or a chemotherapeutic agent. Specifically, the delivery systems of the present invention are capable of delivering an increased amount of therapeutic agent to a tumor as compared to other delivery systems. In particular, the delivery systems of the present invention are capable of accumulating a higher amount of therapeutic agent in a tumor, or in the vicinity of a tumor cell or tumor-supporting cell, resulting in exposure of the tumor cell and tumor-associated endothelial cell to therapeutic levels of the agent for a longer period of time as compared to other delivery systems. The present invention also describes pharmaceutical compositions comprising the delivery systems of the present invention. The present invention further relates to a tumor treatment comprising an increased amount of therapeutic agent delivered by the system of the present invention as compared to other delivery systems. The delivery systems and pharmaceutical compositions can be administered to a subject, preferably a human, alone or in combination, sequentially or simultaneously, with other prophylactic or therapeutic agents and/or anti-cancer treatments. | 04-09-2009 |
20090084679 | APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS - The present invention provides an on-chip packed reactor bed design that allows for an effective exchange of packing materials such as beads at a miniaturized level. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors. | 04-02-2009 |
20090042301 | TEMPERATURE REGULATED GENE EXPRESSION - A method for regulation of gene expression by variation of temperature uses a riboswitch. The riboswitch includes a 5′-UTR construct of crhC which alters its secondary structure in response to temperature, resulting in a more stable transcript at lower temperatures, permitting translation. At higher temperatures, the transcript is destabilized and functionally inactive. The 5′-UTR construct of crhC may be operatively linked to a promoter and a gene and administered to cells with an expression vector. | 02-12-2009 |
20090041733 | METHODS FOR CELL MOBILIZATION USING IN VIVO TREATMENT WITH HYALURONAN (HA) - The use of forms of hyaluronic acid having a molecular weight less than about 750,000 daltons selected from the group consisting of hyaluronic acid and pharmaceutically acceptable salts thereof is provided for the same purposes known for using recombinant GM-CSF or G-CSF. | 02-12-2009 |
20090029941 | METHODS FOR CELL MOBILIZATION USING IN VIVO TREATMENT WITH HYALURONAN (HA) - The use of forms of hyaluronic acid having a molecular weight less than about 750,000 daltons selected from the group consisting of hyaluronic acid and pharmaceutically acceptable salts thereof is provided for the same purposes known for using recombinant GM-CSF or G-CSF. | 01-29-2009 |
20080261962 | METHOD OF INHIBITION OF RESPIRATORY DEPRESSION USING POSITIVE ALLOSTERIC AMPA RECEPTOR MODULATORS - The invention is directed to a method for alleviating respiratory depression in a subject as a result of disease of pharmacological agents such as opiates, opioids or barbiturates. The invention also discloses pharmaceutical compositions for use with the method, the composition containing in combination, an analgesic, anaesthetic, or a sedative and a positive allosteric AMPA receptor modulator in an amount sufficient to reduce or inhibit respiratory depression caused by the analgesic, anaesthetic, or sedative. | 10-23-2008 |
20080259976 | Organic Columnar Thin Films - A thin film includes a substrate and a transparent, porous film of organic material, such as 8-hydroxyquinoline aluminum. The organic material is vapor deposited on the substrate such that the film has distinct helical columns extending away from the substrate. | 10-23-2008 |
20080242616 | PEPTIDE SPECIFICITY OF ANTI-MYELIN BASIS PROTEIN AND THE ADMINISTRATION OF MYELIN BASIC PROTEIN PEPTIDES TO MULTIPLE SCLEROSIS PATIENTS - Human myelin basic protein (h-MBP) has a molecular weight of 18.5 KD and contains 170 amino acid residues. Synthetic peptides ranging in length from about 8 to 25 residues and covering the entire length of the protein have been produced. Antibodies to h-MBP (anti-MBP) were found to be neutralized by the synthetic peptides, in vitro, which span the h-MBP from about amino acid residue 61 to about amino acid residue 106. The peptides, which cover both the amino (about residues 1 to 63) and carboxy (about residues 117 to 162) terminals of h-MBP did not neutralize purified anti-MBP. Intrathecal administration of peptide MBP(75-95), MBP(86-95), or MBP(82-98) produced complete binding-neutralization of free (F) anti-MBP with no change in bound (B) levels. A control peptide MBP35-58 had no effect on F or B anti-MBP levels. Intravenous administration of MBP(75-95), MBP(86-95), or MBP(82-98) resulted in significant decline of F and B CSF anti-MBP levels. Administration of MBP synthetic peptides to MS patients either intrathecally or intravenously did not have any adverse neurological effects and systemic complications did not occur. The MBP epitope for MS anti-MBP has been localized to an area between amino acid 86 and amino acid 95. | 10-02-2008 |
20080237146 | APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS - An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising: providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors. | 10-02-2008 |