THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE Patent applications |
Patent application number | Title | Published |
20160130654 | SYSTEMS AND METHODS FOR DIAGNOSING AND TREATING CANCER - Embodiments of the invention provide a method detecting and treating cancer, such as lung cancer. In some aspects, the method may include detecting cancer in a subject, which may comprise assessing the expression of a marker in a sample from the subject. For example, the marker may comprise Mcl-1. In some embodiments, if the subject is diagnosed as having cancer, the method may further provide administering a therapeutically effective amount of a substance that reduces the expression level of Mcl-1 to the subject and then administering a treatment modality that is known to treat the cancer. | 05-12-2016 |
20160102360 | GENETIC SIGNATURE OF VULNERABILITY TO INHIBITORS OF BASE EXCISION REPAIR (BER) IN CANCER - The invention relates to the identification of genetic signatures and expression profiles that are a part of the Base Excision Repair (BER) pathway, a major DNA repair pathway that modifies base lesions. In one embodiment, the present invention provides a method of determining responsiveness of treatment by BER inhibitors for malignant glioma by determining the presence of a low level of expression of Apex 1, a low level of expression of Apex 2, and a high level of expression of MPG. | 04-14-2016 |
20160051702 | SYSTEMS AND METHODS FOR PRECLINICAL MODELS OF METASTASES - Embodiments of the invention provide methods of creating clinical models for different forms of metastatic cancer. The methods may include obtaining samples from subjects with metastatic cancer, determining an allelic status of one or more markers in the samples (e.g., creating a molecular profile of the subject's cancer), and using model organisms with subject-derived xenografts for treatment selection. | 02-25-2016 |
20160040217 | METHODS AND KITS TO DETECT AND GENOTYPE CRYPTOCOCCUS SPECIES - Embodiments of the invention provide a method of genotyping a | 02-11-2016 |
20160038498 | METHODS FOR THE TREATMENT OF CANCER - The present invention is directed to methods for treating cancer in a subject, such as a cancer of the endocrine system. In some aspects, the method includes administering to the subject one or more of a polo-like kinase 1 inhibitor, a mouse double minute 2 inhibitor, and/or a mitotic catastrophe inducing compound. In other aspects, the method includes measuring an expression level of one or more markers, including caspase 8 and caspase 9, to assess the functionality of the caspase cascade in the subject. | 02-11-2016 |
20160038492 | Targeted Therapies for Cancer - Methods of selecting a chemotherapy regimen for treatment of cancer in a patient are disclosed. A patient genetic sample from a bilary cancer such as cholangiocarcinoma is analyzed for a mutation in ERRFI1 and a chemotherapeutic agent is selected as a result of the analysis. If a mutation in ERRFI1 is present, treatment with an inhibitor of Epidermal Growth Factor Receptor (EGFR) is shown to have inhibitory effects on tumor growth. In this manner, the chemotherapy regimen is targeted to a given mutation in a patient's cancer. | 02-11-2016 |
20160033535 | Methods for the Diagnosis of Amyotrophic Lateral Sclerosis - The present invention is directed to systems and methods for diagnosing amyotrophic lateral sclerosis (ALS) by assessing the expression level of a marker, FGGY. In other aspects, the present invention is also directed to systems and methods of establishing a prognosis of ALS disease severity by assessing the expression level of FGGY. | 02-04-2016 |
20160032002 | Hybridoma Clones and Monoclonal Antibodies to CD9 - The present invention is directed to a monoclonal antibody that recognizes human CD9 in its native form. The invention is also directed to a hybridoma cell line that produces the monoclonal antibody, and exosome isolation kits using the antibody. | 02-04-2016 |
20160017027 | Hybridoma Clones and Monoclonal Antibodies to Fibroblast Growth Factor 4 - The present invention is directed to a monoclonal antibody that recognizes human FGFR4 in its native form. The invention is also directed to a hybridoma cell line that produces the monoclonal antibody and methods of use thereof. | 01-21-2016 |
20160001198 | Mobile Phase Degassing for Nano-Flow Liquid Chromatography - Systems and methods for degassing liquids in nano-flow liquid applications ( | 01-07-2016 |
20150329916 | METHODS AND KITS USED IN CLASSIFYING ADRENOCORTICAL CARCINOMA - The invention encompasses methods and kits used to detect biomarkers that may be used to predict disease outcome in adrenocortical carcinoma patients. | 11-19-2015 |
20150323538 | SYSTEMS AND METHODS FOR DIAGNOSING AND TREATING CANCER - Embodiments of the invention provide a method detecting and treating cancer, such as lung cancer. In some aspects, the method may include detecting cancer in a subject, which may comprise assessing the expression of a marker in a sample from the subject. For example, the marker may comprise c-Met and/or Fn14. In some embodiments, if the subject is diagnosed as having cancer, the method may further provide administering a therapeutically effective amount of a substance that reduces the expression level of Fn14 to the subject to reduce the invasive and migratory capabilities of the cancer. | 11-12-2015 |
20150320785 | METHODS USED TO IDENTIFY AND TREAT GLIOBLASTOMA - The invention encompasses methods and kits used in the identification of invasive glioblastoma based upon the expression of TROY. The methods and kits also allow prediction of disease outcome as well as therapeutic outcome. | 11-12-2015 |
20150232896 | ISOLATED GENES AND TRANSGENIC ORGANISMS FOR PRODUCING BIOFUELS - Methods for the production of lipids and biofuels with a culture of | 08-20-2015 |
20150216848 | COMPOUNDS THAT INHIBIT TAU PHOSPHORYLATION - The present invention provides methods and compositions for enhancing working memory impaired in a tau pathological condition associated with AD or Down's syndrome. | 08-06-2015 |
20150196559 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF HYDROXAMIC ACID DERIVATIVES - The invention encompasses a compound derived from hydroxamic acid that may be used to slow the expansion of cancer cells and thus is effective in the treatment of cancer. Generally, the disclosed compound includes a benzimidazole group coupled to a hydroxyamide of five or more unsubstituted carbon atoms and any pharmaceutically acceptable salts, solvates and chemically protected forms thereof. Also disclosed are pharmacological compositions including the compound and methods of using the compound to slow the expansion of cancer cells as well as methods of using the compound to treat cancer. | 07-16-2015 |
20150072348 | SYSTEMS AND METHODS FOR DIAGNOSING AND TREATING CANCER - This invention identifies and provides a recurrent translocation t(4;8) (p16.2; p23.1) associated with certain cancers and other abnormal cell growth disorders and diagnostic methods using the translocation by FISH hybridization or FOR based assays. | 03-12-2015 |
20140322243 | METHODS OF DETECTING BREAST CANCER BRAIN METASTASIS WITH GENOMIC AND EPIGENOMIC BIOMARKERS - The present invention provides a method of diagnosing a breast cancer central nervous system (CNS) metastasis in a subject, comprising determining the expression level of at least one biomarker in a subject-derived brain or breast tissue comparing the subject-derived expression level with a normal control level obtained from normal brain or breast cells; and correlating an increase or decrease of the subject-derived expression level as compared to the normal control level to a diagnosis of a breast cancer CNS metastasis. The present invention also provides a method for the treatment of a breast cancer CNS metastasis in a subject comprising administering to the subject an inhibitor of an overexpressed gene associated with CNS metastasis. | 10-30-2014 |
20140303120 | METHODS FOR THE TREATMENT OF CANCER - The present invention is directed to methods for treating cancer in a subject, such as a cancer of the endocrine system. In some aspects, the method includes administering to the subject one or more of a polo-like kinase 1 inhibitor, a mouse double minute 2 inhibitor, and/or a mitotic catastrophe inducing compound. In other aspects, the method includes measuring an expression level of one or more markers, including caspase 8 and caspase 9, to assess the functionality of the caspase cascade in the subject. | 10-09-2014 |
20140303025 | METHODS FOR THE DIAGNOSIS AND PROGNOSIS OF NEURODEGENERATIVE DISEASES - The present invention provides methods of making determinations regarding the state of cognition within a subject by determining whether a plurality of miRNAs has deregulated biological expression in a sample from the subject. The present invention also provides methods of making determinations regarding the potential severity of pathologies associated with neurodegenerative disorders by determining whether a plurality of miRNAs has deregulated biological expression in a sample from the subject. | 10-09-2014 |
20140287934 | PROCESSES OF IDENTIFYING AND CHARACTERIZING X-LINKED DISORDERS - The present invention relates to processes for characterizing and screening for the existence or predisposition to X-linked disorders associated with changes in X-chromosome inactivation. The present invention also relates to processes of reducing a disease phenotype associated with an X-linked disorder in a female subject. | 09-25-2014 |
20140274741 | METHODS TO CAPTURE AND SEQUENCE LARGE FRAGMENTS OF DNA AND DIAGNOSTIC METHODS FOR NEUROMUSCULAR DISEASE - The present invention provides methods of sequencing a large fragment of DNA by hybridizing a set of specifically designed probes to the DNA, shearing the DNA, and sequencing the DNA with Next Generation Sequencing. The probes are designed to target genes of interest at intervals to allow the capture of relatively large DNA fragments. The present invention also provides methods of diagnosing a neuromuscular disease (NMD) comprising detecting mutations in one or more of SCML2, CHRND, OFD1, DYNC1H1, COL6A3, EMD, ARHGAP4, FLNA, MID1IP1, MID1, and CFP. | 09-18-2014 |
20140272993 | METHOD OF SEQUENCING A FULL MICRORNA PROFILE FROM CEREBROSPINAL FLUID - The present invention provides methods of purifying RNA from a biological sample comprising two separate aqueous extractions of the organic phase obtained by mixing the biological sample with a first solution comprising guanidinium isothiocyanate and beta-mercaptoethanol and a second solution comprising phenol, chloroform, and isoamyl alcohol. Also provided are methods of sequencing RNA purified from a biological sample and methods of diagnosing Alzheimer's disease and Parkinson's disease in a subject by determining whether a plurality of miRNAs has deregulated expression in biological sample from the subject. | 09-18-2014 |
20140248630 | METHODS AND KITS USED IN THE DETECTION OF FUNGUS - The invention encompasses method of using quantitative PCR to detect fungal organisms in clinical and environmental samples to generate standards that allow the quantification of fungal organisms in the samples. | 09-04-2014 |
20140195165 | SYSTEMS AND METHODS FOR IDENTIFYING THE RELATIONSHIPS BETWEEN A PLURALITY OF GENES - The present invention relates to a method and system for the evaluation of differential dependencies of a set of discrete random variables between two conditions. In some embodiments, the system and method compares two conditions by evaluating the probability distributions of the likely dependency networks from random variables. | 07-10-2014 |
20140113930 | THERAPEUTIC COMBINATION FOR CANCER TREATMENT - This invention relates to a synergistic pharmaceutical combination of glucose lowering drugs and autophagy inhibitors, kits containing such combinations, and methods of using such combinations to treat subjects suffering from cancers carrying a specific KRAS mutation. This invention also relates to a theranostic method for cancer treatment. | 04-24-2014 |
20140113834 | HYBRIDOMA CLONES AND MONOCLONAL ANTIBODIES TO ING4 - The present invention is directed to a monoclonal antibody that recognizes human ING4 in its native form. The invention is also directed to a hybridoma cell line that produces the monoclonal antibody, and to methods of diagnosing cancer using the antibody. | 04-24-2014 |
20140057261 | METHODS OF DIAGNOSING, CLASSIFYING AND TREATING ENDOMETRIAL CANCER AND PRECANCER - Diagnostic and therapeutic applications for endometrial cancer are described. The diagnostic and therapeutic applications are based on certain activation mutations in the FGFR2 gene and its expression products. The present invention is directed to nucleotide sequences, amino acid sequences, probes, and primers related to FGFR2 activation mutants and kits comprising these mutants to diagnosis and classify endometrial cancer in a subject. | 02-27-2014 |
20140031403 | Solid Forms of Curcumin - The present invention provides forms of curcumin and the pharmaceutical compositions thereof. The forms of curcumin disclosed herein are curcumin polymorph Form III, curcumin-2-aminobenzimidazole co-crystal, and curcumin-L-lysine co-crystal. Further, the invention provides methods inhibiting cancer cells and HSV-1 using these curcumin novel solid forms. | 01-30-2014 |
20130273063 | METHODS AND KITS TO PREDICT THERAPEUTIC OUTCOME OF BTK INHIBITORS - Methods of tests that assess the expression of DPC4 (SMAD4) to identify subjects with pancreatic cancer that are likely or unlikely to respond to treatment with BTK inhibitors; methods of treating subjects based on identification of said subjects as likely to respond to treatment with BTK inhibitors; therapeutic targets for cancers, particularly cancers with inactivated DPC4 gene or protein; methods of screening of new therapeutic agents using the target; pharmaceutical composition comprising BTK inhibitors, such as PCI-32765 or derivatives thereof, for cancer treatment; and kits that facilitate the performance of the methods are disclosed. | 10-17-2013 |
20130209460 | METHODS AND KITS USED IN IDENTIFYING GLIOBLASTOMA - The invention encompasses methods and kits used in the identification of invasive glioblastoma based upon the expression of TROY. The methods and kits also allow prediction of disease outcome as well as therapeutic outcome. | 08-15-2013 |
20130045982 | BENZAMIDE DERIVATIVES - Disclosed are benzamide derivatives useful in slowing the expansion of cancer cells including the killing of cancer cells and in the treatment of cancer. | 02-21-2013 |
20120289416 | METHODS AND KITS USED IN ASSESSING CANCER RISK - Methods of assessing the risk of recurrence of endometrial cancer on the basis of the presence or absence of mutations in FGFR2 are disclosed. | 11-15-2012 |
20120178093 | METHODS OF ASSESSING A RISK OF CANCER PROGRESSION - Methods and kits that use miRNA expression to predict the development of brain metastases in non-small cell lung cancer patients are disclosed. | 07-12-2012 |
20120149586 | METHODS OF PREDICTING THE RISK OF RECURRENCE OF CANCER - Disclosed herein are methods of predicting the risk of recurrence of cancer on the basis of the expression of microRNA of the miR-520 family. | 06-14-2012 |
20120136029 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF 2-ARYL PYRIDYLAZOLES - A 2-aryl-pyridylazole compound and derivatives useful in slowing the growth of cancer cells are disclosed. Also disclosed are methods of synthesizing the compound, methods of using pharmaceutical compositions containing the compound as an ingredient to slow the growth of cancer cells, and methods of treating cancer patients with pharmaceutical compositions containing the compound as an ingredient. | 05-31-2012 |
20120107796 | METHODS AND KITS TO DETECT NEW H1N1 "SWINE FLU" VARIANTS - Methods and kits used in the detection of the H1N1/09 influenza virus are disclosed. The methods comprise methods of using the nucleic acids to detect H1N1/09 generally as well as H1N1/09 variants resistant to antiviral compositions. | 05-03-2012 |
20120095030 | METHODS AND KITS TO PREDICT THERAPEUTIC OUTCOME OF TYROSINE KINASE INHIBITORS - Methods of using specific microRNA to identify subjects with non-small cell lung cancer likely or unlikely to respond to treatment with tyrosine kinase inhibitors such as erlotinib, sunitinib, or vandetanib; methods of treating subjects based on identification of said subjects as likely to respond to treatment with tyrosine kinase inhibitors; and kits that facilitate the performance of the methods are disclosed. | 04-19-2012 |
20120088681 | METHODS AND KITS USED IN CLASSIFYING ADRENOCORTICAL CARCINOMA - The invention encompasses methods and kits used to detect biomarkers that may be used to predict disease outcome in adrenocortical carcinoma patients. | 04-12-2012 |
20120003209 | METHODS AND KITS USED IN IDENTIFYING GLIOBLASTOMA - The invention encompasses methods and kits used in the identification of invasive glioblastoma based upon the expression of Akt1, Akt2, and Akt3. The methods and kits also allow prediction of disease outcome and staging of patients with regard to therapy. | 01-05-2012 |
20110312504 | METHODS, KITS, AND COMPOSITIONS FOR DETECTION OF MRSA - The present invention provides multiplex assays, methods and kits that may be used to detect and confirm the presence of MRSA in a sample. The methods include real-time PCR assays, and the kits and compositions include oligonucleotides used as primers and probes. The present invention further comprises assays useful to identify and differentiate MRSA, MSSA, MRSE, MSSE, MRCNS and MSCNS in a sample. | 12-22-2011 |
20110275084 | METHODS OF DETERMINING SUSCEPTIBILITY OF TUMORS TO TYROSINE KINASE INHIBITORS - This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly FGFR2 variants, which are linked to drug resistance. The disclosure further provides methods of diagnosis and theranosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions. | 11-10-2011 |
20110263462 | METHODS AND KITS USED IN THE DETECTION OF FUNGUS - The invention encompasses methods of using quantitative PCR to detect fungal organisms in clinical and environmental samples and to generate standards that allow the quantification of fungal organisms in the samples. | 10-27-2011 |
20110262426 | METHODS AND KITS USED IN IDENTIFYING GLIOBLASTOMA - The invention encompasses methods and kits used in the identification of invasive glioblastoma based upon the expression of TROY. The methods and kits also allow prediction of disease outcome as well as therapeutic outcome. | 10-27-2011 |
20110230363 | METHODS, KITS, AND COMPOSITIONS USEFUL IN SELECTING AN ANTIBIOTIC TO TREAT MRSA - The present invention provides a method, a kit and composition for determining MRSA and other | 09-22-2011 |
20110171323 | METHODS AND KITS TO PREDICT PROGNOSTIC AND THERAPEUTIC OUTCOME IN SMALL CELL LUNG CANCER - Disclosed herein are methods used in the identification of cancer patients likely or unlikely to respond to systemic chemotherapy, methods of treating cancer patients based upon the identification, and kits that facilitate the identification. The methods and kits involve detecting the expression of specific microRNA. | 07-14-2011 |
20110092385 | COMPOSITIONS AND METHODS TO DETECT INFLUENZA VARIANTS - Methods and kits used in the detection of variants of the Influenza virus are disclosed, including variants that are resistant to treatment with antiviral compositions. | 04-21-2011 |