UNIVERSITY OF WASHINGTON through its Center for Commercialization Patent applications |
Patent application number | Title | Published |
20160137806 | SOLID-STATE THERMOPLASTIC NANOFOAMS - Disclosed is a solid state foaming method for the creation of nanofoams (about or less than 100 nm) by saturating thermoplastic polymers with liquid carbon dioxide, optionally, at low saturation temperatures of below room temperature and lower. | 05-19-2016 |
20160121318 | HYDROGENATION AND DISPROPORTIONATION CATALYSIS - Improved catalytic methods are disclosed. The methods include both hydrogenation and disproportionation catalysis. While the reaction conditions for hydrogenation and disproportionation differ, the catalysts disclosed herein can be used for either process. In certain aspects, the methods utilize a catalyst: CpM(N—N)L | 05-05-2016 |
20160116464 | STIMULI-RESPONSIVE MAGNETIC NANOPARTICLES - The present disclosure provides stimuli-responsive magnetic nanoparticles, methods of making the magnetic nano-particles, and methods of using the magnetic nanoparticles. The magnetic nanoparticles include a metal oxide core; and a shell that includes a stimuli-responsive polymer having a terminal group that directly coordinates to the metal oxide core. The stimuli-responsive polymer does not include a micelle-forming group, at least at a proximal terminus of the polymer, with respect to the metal oxide core. | 04-28-2016 |
20160115538 | Methods and Systems for Using Photoswitchable Nucleic Acids to Control Hybridization Stringency - Compositions, methods and systems are provided that enable light-controlled hybridization between two nucleic acid sequences and further enable the characterization of one or more sequence variations between the nucleic acids. | 04-28-2016 |
20160113667 | ULTRASOUND BASED METHOD AND APPARATUS FOR STONE DETECTION AND TO FACILITATE CLEARANCE THEREOF - Described herein are methods and apparatus for detecting stones by ultrasound, in which the ultrasound reflections from a stone are preferentially selected and accentuated relative to the ultrasound reflections from blood or tissue. Also described herein are methods and apparatus for applying pushing ultrasound to in vivo stones or other objects, to facilitate the removal of such in vivo objects. | 04-28-2016 |
20160079541 | FULLERENE SURFACTANTS AND THEIR USE IN POLYMER SOLAR CELLS - Fullerene surfactant compounds useful as interfacial layer in polymer solar cells to enhance solar cell efficiency. Polymer solar cell including a fullerene surfactant-containing interfacial layer intermediate cathode and active layer. | 03-17-2016 |
20160072008 | SURFACE-PASSIVATED SILICON QUANTUM DOT PHOSPHORS - Phosphors formed using silicon nanoparticles are provided. The phosphors exhibit bright fluorescence and high quantum yield, making them ideal for lighting applications. Methods for making the silicon phosphors are also provided, along with lighting devices that incorporate the silicon phosphors. | 03-10-2016 |
20160058581 | Medial-Lateral Stabilizing Prosthetic Ankle/Foot For Angled And Rough Ground Gait - A device is provided including a first linkage system and a second linkage system. Each linkage system may include an upper support, a lower support, and a cross bar linkage including a first cross bar and a second cross bar. The first cross bar may be configured with a first end pivotally coupled to a first end of the lower support and a second end pivotally coupled to a second end of the upper support. The second cross bar may be configured with a first end pivotally coupled to a second end of the lower support and a second end pivotally coupled to a first end of the upper support. The device may also include a flexible bridging platform coupled to one of the upper support or the lower support of the first linkage system and coupled to the upper support of the second linkage system, and a flexible strut coupled to the lower support of the second linkage system. | 03-03-2016 |
20160045879 | DYNAMIC SEAL TO ENABLE MOVEMENT OF A FILM OR FIBER THROUGH A PRESSURIZED SPACE WHILE MAINTAINING A DESIRED PRESSURE - The present disclosure describes devices capable of continually and controllably passing a polymer film or fiber through a pressurized vessel, while maintaining a desired pressure inside the vessel. In certain embodiments, the devices of the present disclosure include dynamic seals capable of limiting the gas flow from the pressurized vessel to lower pressure environments. | 02-18-2016 |
20160030517 | COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF NEUROLOGICAL DISEASE - Provided herein are methods, assays and compositions relating to the treatment of neurological diseases and disorders, particularly by modulating expression and/or activity of Bif-1. | 02-04-2016 |
20160018405 | METHODS AND SYSTEMS FOR ANALYSIS USING POLYMER DOTS - Methods, systems, compositions and kits are provided for the analysis of target molecules using chromophoric polymer dots conjugated to biomolecules. The use of chromophoric polymer dots improves detection sensitivity and stability when compared with existing techniques. In some aspects, methods, systems, and kits are provided for detecting a target protein using chromophoric polymer dots conjugated to biomolecules in a Western blot analysis. Related methods, systems, compositions and kits are also provided. | 01-21-2016 |
20160002416 | STYRENE-ETHYLENE/BUTYLENE-STYRENE BLOCK COPOLYMER DEVICES - This disclosure describes polymeric devices including a polystyrene-b-poly(ethylene-co-butylene)-b-polystyrene having a styrene content of between 15 wt % and 70 wt %. The polymeric devices include a predetermined structural feature having a dimension of 20 nm to 1 cm. The polymeric devices can have a surface and a bulk volume, and the styrene content of the surface can differ from the styrene content of the bulk volume of the polymeric devices. | 01-07-2016 |
20150368403 | THERMALLY-ACTIVATED SELF-IMMOLATIVE MATERIALS - A polymer including a self-immolative polymer segment and a thermally-activated trigger moiety is described. The self-immolative polymer segment includes a head end, a tail end, and a plurality of repeating units. The trigger moiety includes a cycloaddition adduct that is covalently coupled to the head end of the self-immolative polymer segment. When the polymer is exposed to an activation temperature, the cycloaddition adduct undergoes retro-cycloaddition to release the self-immolative polymer segment. The self-immolative polymer segment then decomposes to sequentially release repeating units in a head-to-tail direction. | 12-24-2015 |
20150356240 | Self-Assembling Protein Nanostructures - Synthetic nanostructures, proteins that are useful, for example, in making synthetic nanostructures, and methods for designing such synthetic nanostructures are disclosed herein. | 12-10-2015 |
20150333250 | Structures with PZT Nanoparticle Ink Based Piezoelectric Sensor Assembly - A structure is provided having a substrate and a direct write deposited lead zirconate titanate (PZT) nanoparticle ink based piezoelectric sensor assembly deposited on the substrate. The PZT nanoparticle ink based piezoelectric sensor assembly has a PZT nanoparticle ink based piezoelectric sensor with a PZT nanoparticle ink deposited onto the substrate via an ink deposition direct write printing process. The PZT nanoparticle ink does not require a high temperature sintering/crystallization process once deposited. The PZT nanoparticle ink based piezoelectric sensor assembly further has a power and communication wire assembly coupled to the PZT nanoparticle ink based piezoelectric sensor. The power and communication wire assembly has a conductive ink deposited onto the substrate via the ink deposition direct write printing process. | 11-19-2015 |
20150323217 | ELECTRONIC AIR CLEANERS AND ASSOCIATED SYSTEMS AND METHODS - Electronic air cleaners for use in heating, air-conditioning, and ventilation (HVAC) systems and associated methods and systems are disclosed herein. In one embodiment, an electronic air cleaner ( | 11-12-2015 |
20150305739 | MICROSTRUCTURE-BASED WOUND CLOSURE DEVICES - The present invention relates generally to wound closure devices comprising one or more microstructures. The devices are designed such that the microstructures are able to grip the skin or tissue surrounding a wound, optionally closing the wound, or securing the tissue or skin in place. Also provided are wound closure systems that comprise one or more microstructure wound closure devices along with other components, such as protective covers and wound healing therapeutics. A variety of packaging specifications are disclosed, as is a dispenser apparatus configured to enable simple one-handed application of the wound closure devices. Methods described herein provide for the closure of various wounds with the wound closure devices and systems. | 10-29-2015 |
20150301067 | METHODS AND ASSAYS FOR FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY - Provided herein are methods, assays and compositions relating to the treatment of FSHD, particularly by modulating expression of DUX4. | 10-22-2015 |
20150297295 | INSTRUMENT ORGANIZATION SYSTEMS AND ASSOCIATED METHODS - Organization systems for surgical instruments and associated methods and systems are disclosed herein. In one embodiment, a surgical instrument organization system can be configured for use in a medical environment, and can include a flexible, sterile container having a lower portion. The container can include an attachment system configured to elastically couple one or more surgical instruments to the lower portion of the container. In some embodiments, the container can be carried by a portable base coupled to a platform via an adjustable support member. | 10-22-2015 |
20150280444 | WIRELESS POWER DELIVERY IN DYNAMIC ENVIRONMENTS - An adaptive system for efficient and long-range wireless power delivery using magnetically coupled resonators responds to changes in a dynamic environment, and maintains high efficiency over a narrow or fixed frequency range. The system uses adaptive impedance matching to maintain high efficiency. The wireless power transfer system includes a drive inductor coupled to a high-Q transmitter coil, and a load inductor coupled to a high-Q receiver coil. The transmitter coil and receiver coil for a magnetically coupled resonator. A first matching network is (i) operably coupled to the drive inductor and configured to selectively adjust the impedance between the drive inductor and the transmitter coil, or (ii) is operably coupled to the load inductor and configured to selectively adjust the impedance between the load inductor and the receiver coil. | 10-01-2015 |
20150280232 | POLYCRYSTALLINE VANADIUM OXIDE NANOSHEETS | 10-01-2015 |
20150268236 | STIMULI-RESPONSIVE POLYMER DIAGNOSTIC ASSAY COMPRISING MAGNETIC NANOPARTICLES AND CAPTURE CONJUGATES - The present disclosure utilizes the aggregation of stimuli-responsive polymers to isolate a diagnostic target (e.g., an antigen) from a solution using magnetophoresis. Isolating the diagnostic target provides a route to identify the presence of the diagnostic target in the solution. | 09-24-2015 |
20150268229 | METAL-CONTAINING SEMICONDUCTING POLYMER DOTS AND METHODS OF MAKING AND USING THE SAME - The present disclosure provides metal-containing (MC) semiconducting (SC) Pdots (MC-SC-Pdots) with beneficial functionalities in both cellular imaging and manipulation, among other applications. The Pdots comprise at least one nanoparticle comprising at least one metal, and a semiconducting polymer associated with the nanoparticle. | 09-24-2015 |
20150251141 | Apparatuses and Methods for Preventing Fouling and Scaling Using Ultrasonic Vibrations - Described herein are apparatuses and methods for preventing or otherwise reducing scaling and fouling of a membrane using ultrasonic vibrations. One example method involves: (1) directing a solution to a membrane of a membrane assembly, where the membrane passes a solvent of the solution through the membrane at a first rate, and where the membrane prevents at least some of a solute of the solution from passing through the membrane; and (2) causing a piezoelectric material that is physically coupled to the membrane to produce ultrasonic waves directed at the membrane, where the ultrasonic waves induce oscillations in at least a portion of the membrane and thereby the solvent of the solution passes through the membrane at a second rate that is greater than the first rate. | 09-10-2015 |
20150243906 | ACENAPHTHYLENE IMIDE-DERIVED SEMICONDUCTORS - Novel acenaphthylene imide-derived semiconductor materials, including small molecule compounds, polymers and oligomers. Also provided are methods for making the novel semiconductor materials and the use of the novel semiconducting materials in electronic or optoelectronic device. In some embodiments, the novel semiconducting materials are used as n-channel component in organic field-effect transistors as well as complementary electronic circuits including inverters. High mobility can be achieved. | 08-27-2015 |
20150231282 | NANOPARTICLE EMULSIONS - Composites formed from a liquid core encapsulated by a plurality of nanoparticles are provided herein. The composites in certain embodiments are droplets comprising a hydrophobic dispersed phase within a hydrophilic continuous phase, thereby forming an emulsion. The composites can be used as contrast agents for imaging, therapeutic agents, and adapted for other uses according to the unique properties of the composites disclosed herein. | 08-20-2015 |
20150226862 | OPTICAL-INTERFACE PATTERNING FOR RADIATION DETECTOR CRYSTALS - A radiation detector is disclosed that includes a scintillation crystal and a plurality of photodetectors positioned to detect low-energy scintillation photons generated within the scintillation crystal. The scintillation crystals are processed using subsurface laser engraving to generate point-like defects within the crystal to alter the path of the scintillation photons. In one embodiment, the defects define a plurality of boundaries within a monolithic crystal to delineate individual detector elements. In another embodiment, the defects define a depth-of-interaction boundary that varies longitudinally to vary the amount of light shared by neighboring portions of the crystal. In another embodiment the defects are evenly distributed to reduce the lateral spread of light from a scintillation event. Two or more of these different aspects may be combined in a single scintillation crystal. Additionally, or alternatively, similar SSLE defects may be produced in other light-guiding elements of the radiation detector. | 08-13-2015 |
20150200905 | SYSTEMS AND METHODS FOR IMPROVING EFFICIENCY OF ELECTRONIC TRANSMISSION OF MESSAGES - Systems and methods for improving the efficiency of propagating electronic messages are provided. In some embodiments, a feed of activities on a network such as an online social network (OSN) is analyzed to determine influenced activity probabilities and intrinsic activity probabilities for participants in the network. A Helmhotz Green's Function matrix is determined in order to calculate an overall influence weight for each participant in the network. A Woodbury-Sherman-Morrison formula may be used to accelerate computation of the Helmholtz Green's Function matrix, thus allowing efficient updates to the overall influence weights based on newly monitored activities. The participants with the highest overall influence weights may be selected to propagate a new message, thus providing the greatest likely distribution of the message with the fewest originating transmissions. | 07-16-2015 |
20150191782 | COMPOSITIONS AND METHODS FOR IMPROVING NANOPORE SEQUENCING - The present disclosure provides methods and reagents for improving nanopore-based analyses of polymers. Specifically, the disclosure provides a method of analyzing a polymer that includes a polymer analyte that contains an end domain that has at least one charged moiety. The disclosure also provides a method of increasing the interaction rate between a polymer analyte and a nanopore, wherein the polymer analyte contains an end domain that has at least one charged moiety. The disclosure also provide compositions for use with the described methods, including adapter compositions that contain charged moieties, such as phosphate or sulfate groups, and that are configured to being linked to an polymer analyte domain. | 07-09-2015 |
20150157732 | ZWITTERIONIC POLYMER BIOCONJUGATES AND RELATED METHODS - Zwitterionic polymer and mixed charge copolymer bioconjugates, methods for making and using the bioconjugates. | 06-11-2015 |
20150144844 | COMPOSITES INCORPORATING A CONDUCTIVE POLYMER NANOFIBER NETWORK - Methods of forming composites that incorporate networks of conductive polymer nanofibers are provided. Networks of less-than conductive polymers are first formed and then doped with a chemical dopant to provide networks of conductive polymers. The networks of conductive polymers are then incorporated into a matrix in order to improve the conductivity of the matrix. The formed composites are useful as conductive coatings for applications including electromagnetic energy management on exterior surfaces of vehicles. | 05-28-2015 |
20150133609 | NON-FOULING CONDUCTING POLYMERS - Zwitterionic and mixed charge conducting polymers, surfaces modified to include the polymers, bulk constructs that include the polymers, and methods for using the polymers. | 05-14-2015 |
20150132745 | METHODS AND COMPOSITIONS FOR GENERATING REFERENCE MAPS FOR NANOPORE-BASED POLYMER ANALYSIS - The present disclosure generally relates to the methods and compositions to efficiently analyze polymer characteristics using nanopore-based assays. Specifically disclosed is a method for generating reference signals for polymer analysis in a nanopore system, wherein the nanopore system has a multi-subunit output signal resolution. The method comprises translocating a reference sequence through a nanopore to generate a plurality of reference output signals, wherein each possible multi-subunit sequence that can determine an output signal appears only once in the reference sequence. The output signals are compiled into a reference map for nanopore analysis of an analyte polymer. Also provided are methods and compositions for calibrating the nanopore system for optimized polymer analysis. | 05-14-2015 |
20150119482 | METHOD TO ENHANCE CELL NUCLEATION DENSITY IN SOLID-STATE FOAMS - A method for creating a foam from a solid thermoplastic material is disclosed. The method includes heating a solid, noncellular thermoplastic material to a temperature greater than the material's glass transition temperature, and below the melting temperature, and then allowing the material to cool; after the material has cooled, saturating the cooled thermoplastic material with a non-reacting gas to provide a gas-saturated material; and heating the gas-saturated material below the melting temperature of the material so that the material remains a solid, and causes nucleation of bubbles, and creation of cells in the material. | 04-30-2015 |
20150112028 | SYNTHESIS OF CHALOGEN-CAPPED PI-CONJUGATED POLYMERS - Methods for the preparation of mono- and bis-end-functionalized π-conjugated polymers. In the methods, chalcogens are selectively installed at the polymer terminus or termini. | 04-23-2015 |
20150093564 | METHOD FOR MAKING SHAPEABLE MICROCELLULAR POLY LACTIC ACID ARTICLES - A method for making a shapeable article from poly(lactic acid) includes treating solid poly(lactic acid) that results in the solid poly(lactic acid) having a crystallinity of at least 20% by weight based on the weight of the solid poly(lactic acid) and a gas concentration of 6% to 16% by weight based on the weight of the solid poly(lactic acid); and heating the solid poly(lactic acid) having said minimum crystallinity and gas concentration to produce a cellular poly(lactic acid) article that is shapeable. The shapeable cellular poly(lactic acid) article is advantageous in that the article can be further shaped by heat and/or pressure (or vacuum), such as via thermoforming, into a variety of useful products. | 04-02-2015 |
20150065435 | REAGENTS AND METHODS FOR TREATING DENTAL DISEASE - The present invention provides reagents and methods for treating dental disease. | 03-05-2015 |
20150037598 | CROSSLINKED ZWITTERIONIC HYDROGELS - Zwitterionic crosslinking agents, crosslinked zwitterionic hydrogels prepared from copolymerization of zwitterionic monomers with the zwitterionic crosslinking agent, methods for making crosslinked zwitterionic hydrogels, and devices that include and methods that use the crosslinked zwitterionic hydrogels. | 02-05-2015 |
20150035378 | ENERGY HARVESTING AND CONTROL FOR SENSOR NODE - An integrated circuit, such as included as a portion of a sensor node, can include a regulator circuit having an input coupleable to an energy harvesting transducer. The integrated circuit can include a wireless receiver circuit coupled to the regulator circuit and configured to wirelessly receive at least enough operating energy to establish operation of the sensor node without requiring the energy harvesting transducer. The integrated circuit can include a digital processor circuit coupled to the regulator circuit and a power management processor circuit. The digital processor circuit or one or more other circuits can include a subthreshold operational mode established by the power management processor circuit based on the selected energy consumption level. For example, establishing the subthreshold operational mode can include adjusting or selecting a supply voltage so as to establish subthreshold operation of a field effect transistor (FET) in the digital processor circuit or other circuits. | 02-05-2015 |
20150017678 | Systems, Devices, and Methods for Separating, Concentrating, and/or Differentiating Between Cells from a Cell Sample - Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example, the acoustic properties of the cells of interest may be modified by attaching bubbles to the cells of interest. The cell sample may then be subjected to an acoustic wave. The cells of interest may be differentiated and/or separated from the remainder of the sample based on relative displacements and/or volumetric changes experienced by the cells of interest in response thereto. The cells of interest may be separated using a standing wave and sorted into separate channels of a flow cell. Optionally, the cells may be interrogated by a light source and differentiated by signals generated in response thereto. | 01-15-2015 |
20150017207 | Methods and Compositions for Activation of Innate Immune Responses Through RIG-I Like Receptor Signaling - Compositions and methods are provided that enable activation of innate immune responses through RIG-I like receptor signaling. The compositions and methods incorporate synthetic nucleic acid pathogen associated molecular patterns (PAMPs) that comprise elements initially characterized in, and derived from, the hepatitis C virus genome. | 01-15-2015 |
20140374642 | METHODS FOR FORMING LEAD ZIRCONATE TITANATE NANOPARTICLES - Methods for forming lead zirconate titanate (PZT) nanoparticles are provided. The PZT nanoparticles are formed from a precursor solution, comprising a source of lead, a source of titanium, a source of zirconium, and a mineraliser, that undergoes a hydro thermal process. The size and morphology of the PZT nanoparticles are controlled, in part, by the heating schedule used during the hydro thermal process. | 12-25-2014 |
20140343494 | CIRCUMFERENTIAL AEROSOL DEVICE - The present application discloses devices and methods for delivering a therapeutic compound to the olfactory epithelium of an animal or human. The device having one or more channels for imparting a circumferential and axial velocity to the discharged fluid, and an outlet that discharges an aerosol spray having a circumferential and axial velocity as it enters the nasal cavity of a user. The device is designed to displace the air in the upper nasal cavity in order to specifically deposit a therapeutic agent on the olfactory epithelium while minimizing pressure and discomfort experienced by the user. | 11-20-2014 |
20140339499 | SURFACE-PASSIVATED SILICON QUANTUM DOT PHOSPHORS - Phosphors formed using silicon nanoparticles are provided. The phosphors exhibit bright fluorescence and high quantum yield, making them ideal for lighting applications. Methods for making the silicon phosphors are also provided, along with lighting devices that incorporate the silicon phosphors. | 11-20-2014 |
20140336537 | COUGH DETECTING METHODS AND DEVICES FOR DETECTING COUGHS - Examples of the present invention utilize principal component analysis (PCA) to detect cough sounds in an audio stream. Comparison of all or portions of the audio stream with a cough model may be conducted. The cough model may include a number of basis vectors may be based on initial portions of known coughs. The initial portions may be non-user specific, and accordingly the cough model may be used to detect coughs across individuals. Moreover, examples of the present invention may reconstruct the cough sounds from stored features such that the cough sounds are reconstructed but the reconstruction techniques used may be insufficient to reconstruct speech sounds that may also have been recorded, which may increase user privacy. | 11-13-2014 |
20140328369 | DETECTION OF THERMAL DAMAGE OF COMPOSITES USING MOLECULAR PROBES - Improved methods of detecting thermal exposure are provided herein. The provided methods utilize initially dormant luminescent probes incorporated into a matrix to form a composite. When exposed to heat over a period of time, the luminescent probes are “activated” through a molecular transformation initiated by thermal energy. The activated probes exhibit a luminescent profile based on the extent of thermal exposure, thereby providing an indicator of the thermal exposure experienced by the matrix. When the composite is used to produce a structural component of a vehicle (e.g., an aircraft), the methods provide a convenient, large-area indicator of thermal damage experienced by the structural component. | 11-06-2014 |
20140324327 | METHODS AND SYSTEMS FOR PROVIDING GEOTEMPORAL GRAPHS - Technology for generating geotemporal graphs is disclosed where geotemporal graphs provide representations of areas based on an expected travel time between points, instead of the geographical distance between points. Travel times may vary based on travel conditions, and geotemporal maps may be generated that show travel times that account for travel conditions. Generating geotemporal maps may include obtaining a graph, determining for several points a warp vector indicating graph how each point should be moved to represent a travel time to that point, and warping the graph according to the determined warp vectors. | 10-30-2014 |
20140323857 | ULTRASOUND STYLET | 10-30-2014 |
20140322244 | MIC-BINDING ANTIBODIES AND METHODS OF USE THEREOF - The technology described herein relates to antibodies and/or polypeptides which bind to MIC and inhibit MIC shedding. Methods of using such antibodies and/or polypeptides for the treatment of cancer are also described herein. | 10-30-2014 |
20140321587 | Magnetically Contained Energized Plasma - A method of inductively energizing a plasma in a confinement chamber ( | 10-30-2014 |
20140320661 | INDOOR SCENE CAPTURE SYSTEM - An indoor scene capture system is provided that, with a handheld device with a camera, collects videos of rooms, spatially indexes the frames of the videos, marks doorways between rooms, and collects videos of transitions from room to room via doorways. The indoor scene capture system may assign a direction to at least some of the frames based on the angle of rotation as determined by an inertial sensor (e.g., gyroscope) of the handheld device. The indoor scene capture system marks doorways within the frames of the videos. For each doorway between rooms, the indoor scene capture system collects a video of transitioning through the doorway as the camera moves from the point within a room through the doorway to a point within the adjoining room. | 10-30-2014 |
20140315760 | PHOTONIC BLOOD TYPING - Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined. | 10-23-2014 |
20140315501 | SYSTEMS, TRANSCEIVERS, RECEIVERS, AND METHODS INCLUDING CANCELLATION CIRCUITS HAVING MULTIPORT TRANSFORMERS - Example apparatuses and methods for cancellation of transmitter self interference leakage in a transceiver are described. An example transceiver includes a multiport transformer that may be used as a part of the impedance matching network on the receiver side of the transceiver. One primary port of the multiport transformer may form a portion of a cancellation circuit that, along with other components in a cancellation path, provide amplitude and/or phase modulation to a cancellation signal. The cancellation circuit may tunable and may include only reactive components in some examples. | 10-23-2014 |
20140313172 | SURGICAL INSTRUMENT INPUT DEVICE ORGANIZATION SYSTEMS AND ASSOCIATED METHODS - Organization systems for surgical instruments input devices and associated methods and systems are disclosed herein. In one aspect, a surgical instrument input device organization system can include a first interface configured to receive input from a user and a second interface communicatively coupled to the first interface via a link. The second interface can include a module sized to receive a surgical input instrument device and an actuator configured to engage a movable surface of the surgical instrument input device in response to input received from the user at the first interface. | 10-23-2014 |
20140302516 | POLYMER DOT COMPOSITIONS AND RELATED METHODS - Lyophilized polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions and kits supplying the compositions. | 10-09-2014 |
20140287321 | METHOD TO PRODUCE NANOPOROUS POLYMERIC MEMBRANES - A method for making a flat polymer foam having a core layer of nano-sized open, interconnected cells that includes saturating a solid-state polymer with a supercritical fluid, allowing the gas to desorb for at least 35 minutes, and then heating the gas-saturated solid polymer for at least 3 minutes while constraining the foam in the thickness dimension. Any skin layer formed on the exterior may be removed via polishing, thus creating a foam with an open structure from side to side. The foam can be used as a battery separator. | 09-25-2014 |
20140286872 | NANOPARTICLE FOR TARGETING BRAIN TUMORS AND DELIVERY OF O6-BENZYLGUANINE - Nanoparticle having a crosslinked chitosan-polyethylene oxide oligomer copolymer coating to which O | 09-25-2014 |
20140283569 | ENDOPHYTIC YEAST STRAINS, METHODS FOR ETHANOL AND XYLITOL PRODUCTION, METHODS FOR BIOLOGICAL NITROGEN FIXATION, AND A GENETIC SOURCE FOR IMPROVEMENT OF INDUSTRIAL STRAINS - The present invention provides novel endophytic yeast strains capable of metabolizing both pentose and hexose sugars. Methods of producing ethanol and xylitol using the novel endophytic yeast are provided herein. Also provided are methods of fixing nitrogen and fertilizing a crop using the novel endophytic yeast strains provided herein. | 09-25-2014 |
20140275727 | Implantable Heart Pump Controller - The present invention provides devices, systems, and methods for control of ventricular assist devices. The invention includes an implantable controller that is operatively programmed to direct physiological flow through a ventricular assist device that is substantially synchronized to the cardiac cycle of the subject. The implantable controller is also communicatively connected to an external control unit, such that the implantable controller can transmit data to the external control unit, and instructions can be sent from the external control unit to the implantable controller. | 09-18-2014 |
20140275013 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES - The present invention provides compounds of formula I: | 09-18-2014 |
20140274798 | COMPOUNDS AND METHODS RELATING TO LYSOSOMAL STORAGE DISORDERS - Substrates are provided that include compounds suitable for detecting the activity of an enzyme such as a lysosomal storage enzyme where the substrates include: a sugar moiety; a linker moiety allowing the conjugation of sugar moiety with the remaining structure of the substrate; and two or more fatty acid chains or derivatives thereof at least one of which is sufficiently structured to provide improved solubility in aqueous or organic solvent systems. Also provided are methods for using substrates for detecting enzymatic activity using the inventive substrates. | 09-18-2014 |
20140255476 | COMPOSITIONS, DEVICES, AND METHODS FOR TREATING INFECTIONS - Compositions, devices, and methods for treating infections. | 09-11-2014 |
20140249054 | LYSOSOMAL ENZYME ASSAY METHODS AND COMPOSITIONS - Multiplex enzyme assay methods and compositions for simultaneously assaying the activities of a plurality of lysosomal enzymes. | 09-04-2014 |
20140236002 | Methods and Systems for Imaging Tissue Motion Using Optical Coherence Tomography - A system and method for measuring tissue motion within a living tissue of the anterior segment and aqueous outflow system of the eye in a subject are provided. Tissue movements are extracted from a plurality of images acquired from the living tissue using an optical coherence tomography system. The images may be corrected using motion compensation. To extract the tissue movements from the images, waves from a cardiac pulse or other externally induced pulses from the subject are acquired, and a pulse wave is defined for a given time, which is then correlated with a velocity wave defined for a velocity of tissue and/or fluid movement within the tissue region for the same given time. Pulsatile motion is then isolated in the tissue region from the plurality of images. | 08-21-2014 |
20140235790 | CARBOHYDRATE-BASED COMPOSITIONS AND METHODS FOR TARGETED DRUG DELIVERY - Provided herein are compositions and methods for intracellular delivery. The compositions are polymer compositions in which the polymer serves as a carrier for therapeutic and/or diagnostic agents. The polymer compositions are effective in targeted delivery of therapeutic and/or diagnostic agents to a cell. The polymer compositions include a targeting moiety that includes carbohydrate groups that effectively target specific cell surface receptors. The polymer compositions also include an agent binding moiety that effectively associates the therapeutic and/or diagnostic agent to be delivered to the cell. | 08-21-2014 |
20140232116 | HEAVE PLATES THAT PRODUCE LARGE RATES OF CHANGE IN TETHER TENSION WITHOUT GOING SLACK, AND ASSOCIATED SYSTEMS AND METHODS - Apparatuses and associated methods for converting wave energy into electrical energy are disclosed herein. In some embodiments, a surface-based buoy can be connected to a magnetostrictive element that changes its output voltage when subjected to the in tension. To keep the heave plate under tension, a tether with a heave plate can be attached to the magnetostrictive element. Since the magnetostrictive element can be sensitive to zero tension (e.g., a slack in the tether) followed by a sudden increase in the tension, in at least some embodiments it is preferred to keep the magnetostrictive element tensioned at all times. In some embodiments of the present technology, an inertia-dominated heave plate may be designed to sink faster than the buoy falls in the trough of the wave, therefore keeping the tether tensioned at all times. For example, the design (e.g., mass, diameter, height) of the heave plate can be such that the static force of gravity S exceeds a sum of the drag D and inertia I under expected wave conditions. | 08-21-2014 |
20140221577 | SELF-ASSEMBLED PARTICLES FROM ZWITTERIONIC POLYMERS AND RELATED METHODS - Zwitterionic block copolymers and zwitterionic conjugates that advantageously self-assemble into particles, particles assembled from the zwitterionic block copolymers and zwitterionic conjugates, pharmaceutical compositions that include the self-assembled particles, and methods for delivering therapeutic and diagnostic agents using the particles. | 08-07-2014 |
20140219962 | POROUS CHITOSAN SCAFFOLDS AND RELATED METHODS - Porous chitosan scaffold having high mechanical strength, methods for making the porous chitosan scaffold, and method for using the porous chitosan scaffold. | 08-07-2014 |
20140206628 | Polypeptides for treating and/or limiting influenza infection - Polypeptides are disclosed herein, which recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection. | 07-24-2014 |
20140200724 | Methods and Systems for Bidirectional Charging of Electrical Devices Via an Electrical System - Disclosed herein are methods, systems, and devices that may be implemented by an energy aggregator to control, or regulate, the electric load placed on an electric grid by an aggregation of electrical devices, such as electric vehicles. Generally, the disclosed methods and systems may provide for the bidirectional modulation of the power draw of each electric vehicle around a first power draw, or scheduled power draw. Further, the disclosed methods and systems provide for the determination of a desirable scheduled power draw for a given electric vehicle. In one example, the scheduled power draw may be determined based on, among other things, a respective amount of projected degradation in a given time period of each electrical device from a set of electrical devices. In another example, the scheduled power draw may be determined based on, among other considerations, a maximization of the profit derived by the energy aggregator for both providing power to an aggregation of electric vehicles and for providing a regulation function to the electrical grid (at the request, for example, of an electrical-system operator). | 07-17-2014 |
20140195238 | METHOD AND APPARATUS OF CONFIDENCE MEASURE CALCULATION - An apparatus that calculates a confidence measure of a target word string specified in a recognition result includes: an alternative candidate generator which generates an alternative candidate word string in the position of the target word string; a classifier training unit which trains a classifier which is configured to discriminate between the target word string and the alternative candidate word string; a feature extractor which extracts a feature value representing an adjacent context in the position of the target word string; and a confidence measure calculator which determining whether the true word string in the position of the target word string is the target word string or the alternative candidate word string by using the classifier and the feature value and calculates a confidence measure of the target word string on the basis of the determination result. | 07-10-2014 |
20140194737 | Ultrasound Based Method and Apparatus to Determine the Size of Kidney Stone Fragments Before Removal Via Ureteroscopy - A transducer is used to send an ultrasound pulse toward a stone and to receive ultrasound reflections from the stone. The recorded time between a pulse that is reflected from the proximal surface and a pulse that is reflected either from the distal surface of the stone or from a surface supporting the stone is used to calculate the stone size. The size of the stone is a function of the time between the two pulses and the speed of sound through the stone (or through the surrounding fluid if the second pulse was reflected by the surface supporting the stone). This technique is equally applicable to measure the size of other in vivo objects, including soft tissue masses, cysts, uterine fibroids, tumors, and polyps. | 07-10-2014 |
20140194379 | METHODS FOR THE PRODUCTION OF CHITIN NANOFIBERS AND USES THEREOF - Methods for the production chitin nanofibers and uses thereof. Furthermore, methods for the production of chitin nanofibers and the fabrication of chitin nanofiber structures and devices. | 07-10-2014 |
20140185055 | Methods and Systems for Integrated Imaging Using Optical Coherence Tomography and Photoacoustic Imaging - Systems and methods for photoacoustic imaging are provided. Photoacoustic signals are excited from a body and the excited photoacoustic signals are detected with a low coherence interferometer system serving as a photoacoustic detector. Cross-sectional images of the body are then reconstructed by the system from the detected photoacoustic signals. | 07-03-2014 |
20140179019 | Simultaneous Global Thermometry, Barometry, and Velocimetry Systems and Methods - Microbeads include small preformed microbead substrates, which may comprise, for example, silica particles having a characteristic dimension less than 2 millimeters. A plurality of luminophores are applied to an exposed surface of the microbead substrates, wherein the luminophores are selected for detecting pressure and/or temperature. A plurality of luminophores absorb light at a predetermined wavelength to transition to an excited state, and they luminesce at different wavelengths when returning to the ground state. The luminescence may be phosphorescence or fluorescence. In some embodiments the microbeads include at least one pressure-sensitive luminophore, at least one temperature-sensitive luminophore, and at least one reference luminophore that is neither pressure-sensitive nor temperature-sensitive. In some embodiments the microbeads are configured for use in digital particle image velocimetry. | 06-26-2014 |
20140163697 | Systems and Methods for Modifying Prosthetic Sockets - Systems, methods, and software are provided for modifying a prosthetic socket to better fit a residual limb of a patient. The embodiments disclosed herein may align and compare a first shape corresponding to an interior surface of the prosthetic socket or a residual limb shape to a second shape corresponding to a desired socket shape or a rectified residual limb shape. A socket insert or pad may be manufactured per the comparison. The socket insert or pad may be configured to be affixable within the patient's prosthetic socket to modify the interior surface of the prosthetic socket such that the modified prosthetic socket provides a better fit to the residual limb of the patient. | 06-12-2014 |
20140162436 | INORGANIC NANOSTRUCTURE REACTIVE DIRECT-WRITE AND GROWTH - Methods for forming inorganic nanostructures are provided. The methods create the inorganic nanostructures by positioning a writing electrode (e.g., a conductive “stamp”) spaced nanometers above a substrate such that a precursor is intermediate the two. Applying an electric field, a voltage bias, an ionic current, or an electronic current between the writing electrode and the substrate converts the precursor into an inorganic solid material (e.g., a semiconductor such as silicon or germanium) in the area of the writing electrode. | 06-12-2014 |
20140161893 | POLYMER BLEND PARTICLES FOR INTRACELLULAR DELIVERY OF AGENTS - Core-shell polymer blend particles are described. The particles include a pH-responsive polymeric shell and a pH-irresponsive polymeric core. The core can include a biodegradable hydrolysable polymer and the shell can include a pH-responsive copolymer that can include constitutional units that are cationic and/or anionic at physiological pH. The core-shell polymer blend particles can allow the controlled delivery of agents into a plurality of distinct intracellular compartments. | 06-12-2014 |
20140155910 | Spherical Motion Mechanism - This document discusses, among other things, a mechanism for providing motion having two degrees of freedom and centered on a single point within a sphere. Methods to design the mechanism consistent with specified parameters are also described. | 06-05-2014 |
20140149432 | Systems and Methods for Selection-Based Contextual Help Retrieval - Described herein are systems and methods for selection-based contextual help retrieval. One example method involves (a) receiving first-query data including contextual data, the contextual data indicating a user-interface element type, a user-interface element location, and user-interface element text; (b) determining at least one first-query response based on at least the contextual data; and (c) causing an indication of the determined at least one first-query response to be provided via an output device. | 05-29-2014 |
20140149082 | System to Evaluate Prosthetic Sockets - Systems, methods, and software are provided for assessing manufacturing errors of a prosthetic socket to facilitate a clinical assessment of the socket. The embodiments disclosed herein may align and compare a manufactured socket shape to a desired socket shape to determine whether clinically significant errors are present in the manufactured socket. A mean radial error (MRE) may be calculated and compared to a set threshold. If the MRE falls below the threshold an interquartile range (IQR) may be calculated and compared to an IQR threshold. If the IQR falls below the IQR threshold, surface normal angle errors (SNAE) may be calculated and plotted to the surface model. If the SNAE plot does not include closed contour regions, the socket may proceed to patient fitting. If the MRE or IQR thresholds are exceeded, or if the SNAE plot indicates closed contour regions, the socket may be reshaped accordingly, prior to fitting. | 05-29-2014 |
20140144518 | VIBRATION-DRIVEN DROPLET TRANSPORT DEVICES - Methods and devices are provided for moving a droplet on an elongated track formed on a patterned surface using vibration. The elongated track includes a plurality of patterned transverse arcuate regions such that when the surface is vibrated the droplet is urged along the track as a result of an imbalance in the adhesion of a front portion of the droplet and a back portion of the droplet to the transverse arcuate regions. | 05-29-2014 |
20140134195 | BETA-2 MICROGLOBULIN-DEFICIENT CELLS - The invention provides isolated primate cells preferably human cells that comprise a genetically engineered disruption in a beta-2 microglobulin (B2M) gene, which results in deficiency in MHC class I expression and function. Also provided are the method of using the cells for transplantation and treating a disease condition. | 05-15-2014 |
20140129623 | SYSTEMS AND METHODS FOR PROTECTING DATA FOR SERVER-BASED COMPUTATIONS - Methods and devices configured to provide a key-free, one-way coding of sensitive data such that efficient parallel scaling methods may be used to perform computations related to the sensitive initial data without risking unwanted disclosure of the sensitive initial data are provided. In some embodiments, a set of intermediate representations of the initial data set is calculated using a one-way computation. The set of intermediate representations is then sent to a server computing system for calculating results in a scalable manner. The initial data is secured from unwanted access at the server computing system at least because the one-way computation does not allow the initial data to be derived from the intermediate representations. | 05-08-2014 |
20140119837 | PILE WITH SOUND ABATEMENT - A noise-attenuating pile comprising a pile driving shoe, an outer tube that engages the pile driving shoe, and an inner member that extends through the outer tube and engages the pile driving shoe, wherein the pile is configured to be installed in sediment or other suitable material by driving the inner member with a pile driver, without directly impacting the outer tube, such that the radial outer tube is substantially insulated from the radial expansion waves generated by the pile driver impacting the inner member. In some piles, one of the inner member and the outer tube are removable after installation. In some piles, a seal is provided in a lower end of the channel defined between the inner member and the outer tube, which may be biodegradable, or may be an inflatable bladder, for example. | 05-01-2014 |
20140107014 | Methods and systems for adenovirus interaction with desmoglein 2 (DSG2) - The present invention provides compositions, compounds, and methods relating to recombinant adenoviral-based polypeptides for treating disorders associated with epithelial tissues. | 04-17-2014 |
20140096256 | JOINT PERFORMANCE-VULNERABILITY METRIC FRAMEWORK FOR DESIGNING AD HOC ROUTING PROTOCOLS - A system for routing data along a path that is both efficient and secure is provided. A performance and vulnerability routing system selects a path for routing using a joint metric for a link in a network of nodes. The system calculates the joint metric based on a combination of a performance metric and a vulnerability metric of a link. The performance metric for a link indicates the cost of transmitting data over the link, and the vulnerability metric for the link indicates the security of data that is transmitted over the link. The system combines the performance metric and the vulnerability metric to generate the joint metric, which indicates a joint cost of transmitting data. The system then selects paths for transmitting data that tend to minimize the sum of the joint costs of the links along the paths. | 04-03-2014 |
20140087386 | METHODS AND SYSTEMS FOR PERFORMING DIGITAL MEASUREMENTS - Methods, devices and systems for performing digital measurements are provided. | 03-27-2014 |
20140086693 | PILE WITH LOW NOISE GENERATION DURING DRIVING - A pile with a low effective Poisson's ratio is disclosed, which greatly reduces the sound coupling to the water and sediment or other ground when driving piles. In some embodiments the pile includes geometric features that reduce the radial amplitude of the compression wave generated during hammering by providing a space for circumferential expansion along the length of the pile. The geometric features may comprise slots and/or grooves. In an embodiment, a driving shoe has a perimeter that extends beyond the pile tube such that the sediment produces less of a binding force on the pile. The pile may be formed as a double-shelled pile with either or both shells having effective low Poisson's ratio properties. A bubble generating plenum may be attached to the shoe to further reduce friction during installation. | 03-27-2014 |
20140081174 | Method and Apparatus to Detect the Fragmentation of Kidney Stones by Measuring Acoustic Scatter - During shock wave therapy, a determination is made that a kidney stone has begun to fracture, and then a progress of its fragmentation is assessed. This determination can reduce the number of shock waves used to disintegrate kidney stones, and thereby reduce dose-dependent tissue damage. The identification of fracture is possible through the detection and analysis of resonant acoustic scattering, which is the radiation caused by reverberations within a stone particle that is struck by a shock wave. The scattering frequency can provide both an indication that the kidney stone has fragmented, and an indication of the relative sizes of the fragments. Related concepts employ displacement measurements of kidney stones/fragments to provide both an indication that the kidney stone has fragmented, and an indication of the relative sizes of the fragments. Such techniques can be combined with vibro-acoustography based gating that better targets the stone. | 03-20-2014 |
20140075835 | BLANKET FOR PYROLYSIS OR DRYING OF BIOMASS - The disclosed embodiments are operable to produce biochar from a biomass or to dry a biomass through controlled heating. While prior art technologies are stationary enclosures, the embodiments provided herein are based on a portable, flexible laminated blanket that is draped over a biomass (e.g., a wood slash pile). In this way, the blanket functions as a portable and reusable kiln for pyrolyzing biomass into biochar or drying biomass. | 03-20-2014 |
20140072060 | RECEIVER, APPARATUS, AND METHODS FOR WIRELESSLY RECEIVING DATA FROM A POWER INFRASTRUCTURE - Apparatuses, receivers, systems and methods for receiving data via a power line infrastructure. An exemplary apparatus includes a base station configured to receive a signal from a power line of a structure by coupling to the power line through an electrical outlet. The base station may include an impedance matching circuit configured to match an impedance of the power line of the structure, and a receiver coupled to the impedance matching circuit. The receiver may be configured to demodulate the signal received from the power line of the structure, convert the demodulated signal into a digital signal, and provide the digital signal to a decoder. | 03-13-2014 |
20140070940 | SENSOR NODES, APPARATUSES, AND METHODS FOR WIRELESSLY TRANSMITTING DATA TO A POWER INFRASTRUCTURE - Apparatuses, sensor nodes, systems and methods for modulating and transmitting sensor data wirelessly to an existing power line network are described. An apparatus may include a microcontroller having an oscillator and an input/output buffer. The microcontroller may process an electrical signal and the input/output buffer may drive a digital signal. The apparatus may include a transmitter utilizing the oscillator and the input/output buffer of the microcontroller. The transmitter may include a resonator coupled to the oscillator and modulation circuitry coupled to the oscillator and resonator. The resonator may modulate a frequency of the oscillator responsive to a modulation signal based on the processed electrical signal. The transmitter may further include an antenna coupled to the input/output buffer of the microcontroller for transmission of the data, and a resonant tank coupled to an output of the input/output buffer to provide an analog signal to the antenna. | 03-13-2014 |
20140065611 | MODIFICATION OF NEUROBEHAVIORAL EFFECTS OF MERCURY BY A GENETIC POLYMORPHISM OF COPROPORPHYRINOGEN OXIDASE IN CHILDREN - In one aspect, the present invention provides a method and reagents for predicting a subject's susceptibility or risk to developing a neurobehavioral deficit associated with mercury exposure. The method comprises performing an assay to determine the presence or absence of a CPOX4 polymorphism in one or both alleles of the coproporphyrinogen oxidase (CPOX) gene, and classifying the susceptibility of the subject to developing a neurobehavioral deficit associated with mercury exposure. A subject determined to possess the CPOX4 polymorphism in at least one allele of the CPOX gene is classified as having an increased susceptibility to developing at least one neurobehavioral deficit associated with mercury exposure compared to a subject with no CPOX4 polymorphisms. | 03-06-2014 |
20140063347 | Myopia-Safe Video Displays - In a first aspect, the present invention provides methods for creating video signals including (a) receiving an input video signal including an input red component, an input green component, and an input blue component; (b) determining (i) that a magnitude of the input red component is greater than a magnitude of the input green component and (ii) a differential between the magnitude of the input red component and the magnitude of the input green component; and (c) sending an output video signal including an output red component, an output green component, and an output blue component, where at least one of the following is true: (i) the output red component is decreased by a fractional amount relative to the input red component based on the differential; and/or (ii) the output green component is increased by a fractional amount relative to the input green component based on the differential, and the output blue component is increased by a fractional amount relative to the input blue component based on the differential. | 03-06-2014 |
20140051316 | CENTRIFUGAL ELECTROSPINNING APPARATUS AND METHODS AND FIBROUS STRUCTURES PRODUCED THEREFROM - A centrifugal electrospinning apparatus, centrifugal electrospinning method for the production of fibrous structures, and electrospun fibrous structures are provided. | 02-20-2014 |
20140051072 | THERMOSTABLE POLYMERASES HAVING ALTERED FIDELITY AND METHODS OF IDENTIFYING AND USING SAME - The present invention provides a method for identifying a thermostable polymerase having altered fidelity. The method consists of generating a random population of polymerase mutants by mutating at least one amino acid residue of a thermostable polymerase and screening the population for one or more active polymerase mutants by genetic selection. For example, the invention provides a method for identifying a thermostable polymerase having altered fidelity by mutating at least one amino acid residue in an active site O-helix of a thermostable polymerase. The invention also provides thermostable polymerases and nucleic acids encoding thermostable polymerases having altered fidelity, for example, high fidelity polymerases and low fidelity polymerases. The invention additionally provides a method for identifying one or more mutations in a gene by amplifying the gene with a high fidelity polymerase. The invention further provides a method for accurately copying repetitive nucleotide sequences using a high fidelity polymerase mutant. The invention also provides a method for diagnosing a genetic disease using a high fidelity polymerase mutant. The invention further provides a method for randomly mutagenizing a gene by amplifying the gene using a low fidelity polymerase mutant. | 02-20-2014 |
20140050671 | THERANOSTIC NANOPARTICLE AND METHODS FOR MAKING AND USING THE NANOPARTICLE - Nanoparticle having a poly(beta-amino ester) coating. The poly(beta-amino ester) coating includes one or more therapeutic agents that can be delivered by the particle and one or more anchoring groups that couple the polymer to the nanoparticle's core surface. In certain embodiments, the poly(beta-amino ester) includes one or more polyalkylene oxide groups. The poly(beta-amino ester) can further include a targeting agent to target the nanoparticle to a site of interest and a diagnostic agent that allows for imaging of the particle. Methods for making and using the nanoparticles are also provided. | 02-20-2014 |
20140048699 | METHOD AND SYSTEM FOR SIMULTANEOUSLY FINDING AND MEASURING MULTIPLE ANALYTES FROM COMPLEX SAMPLES - Method and system for detecting multiple analytes from a sample material by desorption ionization, mass analysis, and multivariate statistical analysis. | 02-20-2014 |
20140047452 | Methods and Systems for Scalable Computing on Commodity Hardware for Irregular Applications - A computing system for scalable computing on commodity hardware is provided. The computing system includes a first computing device communicatively connected to a second computing device. The first computing device includes a processor, a physical computer-readable medium, and program instructions stored on the physical computer-readable medium and executable by the processor to perform functions. The functions include determining a first task associated with the second computing device and a second task associated with the second computing device are to be executed, assigning execution of the first task and the second task to the processor of the first computing device, generating an aggregated message that includes (i) a first message including an indication corresponding to the execution of the first task and (ii) a second message including an indication corresponding to the execution of the second task, and sending the aggregated message to the second computing device. | 02-13-2014 |
20130343360 | Optimization of Polling Protocols in Sensor Networks - A communication-management method involves a recurring polling scheme, wherein network nodes are polled by a base station according to optimized and/or user-preferred polling intervals assigned to each network node. The polling interval assigned to a given node may be optimized to minimize and/or achieve user-preferred thresholds for energy consumption and latency associated with each network node in the sensor network. Optimized and/or user-preferred polling intervals may be constrained in accordance with various network performance considerations, for example, a recommended update interval for each network node, characteristics of the network nodes themselves, the duration of the timselots at which the network nodes are polled, and/or other network performance considerations. | 12-26-2013 |
20130333074 | ENHANCER OF CELL DIVISION - The present invention relates to a polypeptide (BIG1) and variants thereof capable of enhancing the rate of cell-division of a microorganism or plant cell, as well as nucleic acid molecules encoding said polypeptides, vectors comprising said nucleic acid molecules and host cells transformed or transfected with said vectors and expressing said polypeptides. The BIG1 polypeptide which has been identified in the marine centric diatom | 12-12-2013 |
20130317377 | Generative Model-Driven Resource-Efficient Monitoring in Body Sensor Networks - Body sensor networks (BSNs) and methods for monitoring an electrocardiogram using such BSNs include a base station that generates an ECG model and an output ECG signal for displaying on a display device, and a sensor platform in electrical communication with the base station. The sensor platform may be configured to receive a sensed ECG signal from one or more sensors, receive an instance of the ECG model, and produce a model ECG signal from the instance. The sensor platform compares the sensed ECG signal to the model ECG signal and, if a deviation of the sensed ECG signal from the model ECG signal exceeds a threshold, transmits deviation data describing the deviation to the base station module. The sensor platform module does not transmit any data to the base station if there is no such deviation. | 11-28-2013 |
20130309171 | PRE-TARGETED NANOPARTICLE SYSTEM AND METHOD FOR LABELING BIOLOGICAL PARTICLES - Nanoparticle system and method for labeling, detecting, and treating biological particles. In the method, targeting functionality (fusion protein) and therapeutic/imaging modalities (nanoparticle) are separated. | 11-21-2013 |
20130302773 | SELF-CONCEPT IMPLICIT ASSOCIATION TEST - The methods and systems described herein enable the administration of Implicit Association Tests (IATs) without the use of “self-concept” or “self-report.” An example method involves a computing system providing a visual indication of categories including (i) a user-associated-objects category (ii) a user-unassociated-objects category, (iii) a positivevalence-objects category, and (iv) a negative-valence-objects category. The categories are grouped into a first group and a second group. The computing system provides an indication of a stimulus. The stimulus may be associated with at least one of the categories. The computing system may then receive input data indicating a correct classification of the stimulus with one of the first group and the second group. Ultimately, the computing system determines an amount of time elapsed between providing the indication of the stimulus and receiving the input data indicating the correct classification of the stimulus with one of the first group and the second group. | 11-14-2013 |
20130296680 | ARRHYTHMIA DETECTION USING HIDDEN REGULARITY TO IMPROVE SPECIFICITY - A method for identifying a target arrhythmia, for example, atrial fibrillation, with very high specificity includes obtaining heart rhythm data such as EKG data, selecting and analyzing a segment of the data for arrhythmia, if an arrhythmia is found then reanalyzing the segment of data for a hidden regularity that would indicate the data is not the target arrhythmia. If no hidden regularity is found, then identifying the segment as the target arrhythmia. | 11-07-2013 |
20130285021 | SOLUTION-PROCESSABLE ELECTRON-TRANSPORT MATERIALS AND RELATED ORGANIC OPTOELECTRONIC DEVICES - Charge transport compounds are provided. The compounds are useful in optoelectronic devices that include the compounds incorporated as a charge-transport layer. Methods for forming films of the compounds are also provided. Additionally, methods are provided for forming films of a charge-transport layer on an active layer of an optoelectronic device. The films are formed from a solution with solubility orthogonal to the solubility of the active layer, such that the active layer is not solvated during deposition of the charge-transport layer. | 10-31-2013 |
20130280262 | Polypeptides and their Use in Treating and Limiting Respiratory Syncytial Virus Infection - The present invention provides polypeptides and compositions thereof for treating or limiting respiratory syncytial virus infection, and computational methods for designing such polypeptides. | 10-24-2013 |
20130274441 | General Method for Designing Self-Assembling Protein Nanomaterials - Methods and systems for computationally designing self-assembling polypeptides are disclosed. A representation of a docked configuration of a symmetric protein architecture can be determined by a computing device configured to computationally symmetrically dock representations of protein building blocks within a representation of a symmetric protein architecture, where symmetrically docking a representation of a particular protein building block can include determining a configuration of the protein building blocks in three-dimensional space within the symmetric protein architecture configured to generate interfaces between building blocks suitable for computational protein interface design. The amino acid sequence of the docked protein building blocks can be computationally modified to specify protein-protein interfaces between the plurality of protein building blocks that are energetically favorable to drive self-assembly of a protein that includes the modified amino acid sequence. | 10-17-2013 |
20130261012 | COMPOSITION AND METHOD FOR DIVERSIFICATION OF TARGET SEQUENCES - The disclosure relates generally to the targeting of genes to, and their integration into, an immunoglobulin (antibody) heavy chain locus. In particular, the methods described herein contemplate replacing the single rearranged heavy chain V, D, and J genes of a B cell lymphoma such as DT40 with independently rearranged V | 10-03-2013 |
20130244115 | V2O5 ELECTRODES WITH HIGH POWER AND ENERGY DENSITIES - Methods are provided for forming films of orthorhombic V | 09-19-2013 |
20130227716 | METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION - Coronatine has been found to enhance binding of the JAZ1 degron to the | 08-29-2013 |
20130225955 | DETERMINATION OF TISSUE OXYGENATION IN VIVO - A system and method for noninvasively determining the oxygenation of a tissue, for example, a muscle, in vivo uses optical methods to optically interrogate the tissue in both a visible wavelength range and a near infrared (NIR) wavelength range. The illuminating light is sculpted in intensity to approximately match the absorbance spectrum, for example, with the visible light having an intensity an order of magnitude greater than the light. Training data is obtained from healthy patients in both the visible and NIR ranges simultaneously and used to calculate muscle oxygenation. | 08-29-2013 |
20130224772 | METHOD FOR DETECTING ANTI-HE4 ANTIBODIES AND METHODS OF DIAGNOSIS AND/OR PROGNOSIS OF CONDITIONS ASSOCIATED WITH HE4-EXPRESSING CELLS - The present invention features, inter alia, compositions and methods related to the detection of HE4-expressing tumor cells in a subject. The methods include detection of anti-HE4 antibodies in a biological sample obtained from the subject. The methods are useful for diagnosis and monitoring the efficacy of treatments for cancers in which HE4 is expressed, for example, ovarian cancer. | 08-29-2013 |
20130224261 | ENVIRONMENTALLY-RESPONSIVE NANOCOMPOSITES AND METHODS OF THEIR USE - Environmentally-responsive composites useful for intracellular delivery of therapeutic agents. | 08-29-2013 |
20130216924 | METHODS AND DEVICES FOR GENERATING ELECTRICITY FROM A FUEL AND AN OXIDANT USING A CAPACITOR - Devices and methods are provided for generating electrical power using a capacitor. The capacitor has a catalytic working electrode, a dielectric, and a counter electrode. Power is generated by flowing a fuel (e.g., hydrogen gas) over the working electrode, charging the capacitor (e.g. by applying a voltage), flowing an oxidant (e.g., oxygen gas) over the working electrode, and connecting the electrodes to a resistive load, which allows current to flow through the load, between the electrodes. The inverse device (i.e., oxidant first, then fuel) functions similarly. | 08-22-2013 |
20130203605 | MASSIVELY PARALLEL CONTIGUITY MAPPING - Contiguity information is important to achieving high-quality de novo assembly of mammalian genomes and the haplotype-resolved resequencing of human genomes. The methods described herein pursue cost-effective, massively parallel capture of contiguity information at different scales. | 08-08-2013 |
20130197340 | Potential Artery-to-Vein Disease State Detection - A method/apparatus/system for detection of a potential disease state is disclosed. A pair of electrodes is attached to a limb and the electrodes are energized. The energizing of the electrodes creates a first signal in the form of current data. If the first signal is consistent with a potential disease state, including a potential artery-to-vein disease state, an indication of the potential disease state is provided. | 08-01-2013 |
20130196359 | SYSTEMS AND METHODS FOR BIOTRANSFORMATION OF CARBON DIOXIDE INTO HIGHER CARBON COMPOUNDS - Systems, compounds and methods for the conversion of C1 carbon compounds to higher carbon compounds useful for the generation of commodity compounds. | 08-01-2013 |
20130189367 | NANOVECTORS FOR TARGETED GENE SILENCING AND CYTOTOXIC EFFECT IN CANCER CELLS - Nanoparticle having a coating comprising a polyethylenimine and a chitosan-polyethylene oxide oligomer copolymer, and methods for making and using the nanoparticle. The nanoparticle can have a core that includes a material that imparts magnetic resonance imaging activity to the particle and, optionally, include one or more of an associated therapeutic agent, targeting agent, and fluorescent agent. | 07-25-2013 |
20130178960 | SYSTEMS AND METHODS FOR REMOTE MONITORING OF EXERCISE PERFORMANCE METRICS - The present technology describes various embodiments of systems and methods for remote monitoring of exercise performance metrics. In several embodiments, for example, a method of evaluating an exercise performed by a patient includes providing the patient with a pre-recorded avatar showing an exemplary instance of a prescribed exercise. The method further includes sensing the patient's movement during an exercise session and generating a real-time avatar based on the sensing. The pre-recorded avatar can be overlaid with the real-time avatar. The graphic overlay readily shows the patient whether and where his motion and/or body position deviate from the prescribed exercise. The overlay can be made in real time. In several embodiments, the patient's independently-recorded avatar and/or performance metrics are transmitted to the exercise prescriber to monitor the fidelity with which the patient is able to reproduce the exercise outside the prescriber's supervision. | 07-11-2013 |
20130160827 | FULLERENE SURFACTANTS AND THEIR USE IN POLYMER SOLAR CELLS - Fullerene surfactant compounds useful as interfacial layer in polymer solar cells to enhance solar cell efficiency. Polymer solar cell including a fullerene surfactant-containing interfacial layer intermediate cathode and active layer. | 06-27-2013 |
20130158711 | ACOUSTIC PROXIMITY SENSING - An acoustic pretouch sensor or proximity sensor ( | 06-20-2013 |
20130156737 | Secretion System and Methods for its Use - The present invention provides reagents and methods for inhibiting bacterial infection and abnormal cell growth, as well as for selection cloning of nucleic acid inserts. | 06-20-2013 |
20130149539 | TUNED MULTIFUNCTIONAL MAGNETIC NANOPARTICLES FOR BIOMEDICINE - Magnetic nanoparticles and related devices and methods are described. Compositions and methods can include magnetic nanoparticles having a narrow size distribution for use in diagnostics and therapeutics. | 06-13-2013 |
20130145216 | SYSTEMS AND METHODS FOR HARDWARE-ASSISTED TYPE CHECKING - Devices and methods of providing hardware support for dynamic type checking are provided. In some embodiments, a processor includes a type check register and support for one or more checked load instructions. In some embodiments, normal load instructions are replaced by a compiler with the checked load instructions. In some embodiments, to perform a checked load, an error handler instruction location is stored in the type check register, and a type tag operand is compared to a type tag stored in the loaded memory location. If the comparison succeeds, execution may proceed normally. If the comparison fails, execution may be transferred to the error handler instruction. In some embodiments, type prediction is performed to determine whether a checked load instruction is likely to fail. | 06-06-2013 |
20130145169 | EFFICIENT AUTHENTICATION FOR MOBILE AND PERVASIVE COMPUTING - A method and system for authenticating messages is provided. A message authentication system generates an encrypted message by encrypting with a key a combination of a message and a nonce. The message authentication system generates a message authentication code based on a combination of the message and the nonce modulo a divisor. To decrypt and authenticate the message, the message authentication system generates a decrypted message by decrypting with the key the encrypted message and extracts the message and the nonce. The message authentication system then regenerates a message authentication code based on a combination of the extracted message and the extracted nonce modulo the divisor. The message authentication system then determines whether the regenerated message authentication code matches the original message authentication code. If the codes match, then the integrity and authenticity of the message are verified. | 06-06-2013 |
20130143794 | POLYPEPTIDES FOR TREATING AND/OR LIMITING INFLUENZA INFECTION - The present invention provides polypeptides according to the general formulas disclosed herein, which recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection. The present invention further provides isolated nucleic acids encoding the polypeptides of the invention, recombinant expression vectors comprising the nucleic acids encoding the polypeptides of the invention operatively linked to a suitable control sequence, and recombinant host cells comprising the recombinant expression vectors of the invention. The present invention also provides antibodies that selectively bind to the polypeptides of the invention, and pharmaceutical compositions comprising one or more polypeptides according to the invention and a pharmaceutically acceptable carrier. Additionally, the present invention provides methods for treating and/or limiting an influenza infection, methods for diagnosing an influenza infection, or monitoring progression of an influenza infection, methods for identifying candidate influenza vaccines, and methods for identifying candidate compounds for treating, limiting, and/or diagnosing influenza infection. | 06-06-2013 |
20130140506 | HOST-GUEST MATERIALS HAVING TEMPERATURE-DEPENDENT DUAL EMISSION - A composition is provided comprising a host material and a luminescent dopant. The composition exhibits dual luminescent emission peaks, one each for the host material and the luminescent dopant. The intensity of the emission peaks vary in intensity as a result of the changing temperature of the composition. This quality enables the composition to be used for ratiometric optical thermometry, including exemplary applications, such as in situ temperature sensing. | 06-06-2013 |
20130140180 | SHEATH-FLOW ELECTROSPRAY INTERFACE - A sheath-flow interface for producing electrospray from a capillary is provided. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. In the interface, electrokinetic flow moves a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The mixture of sheath liquid and analyte is directed to an electrospray emitter in order to generate an electrospray. | 06-06-2013 |
20130123610 | MRI-COMPATIBLE DEVICE FOR OBTAINING SOFT TISSUE PROPERTIES IN VIVO - A method and apparatus for obtaining force versus deformation data for tissue in vivo includes a displacement system that cycles an anatomical member, for example, a foot, repeatedly through a loading/unloading cycle while using a gated imaging procedure such as magnetic resonance imaging to obtain the deformation response of tissues in the foot. The imaging is conducted during the loading/unloading cycle, such that a rate-dependent deformation response is imaged. | 05-16-2013 |
20130086067 | CONTEXT-AWARE SUGGESTIONS FOR STRUCTURED QUERIES - A suggestion system for providing suggestions of features for inclusion in a clause of a structured query. The suggestion system receives a partial query that is being created by a user. The suggestion system analyzes a query log having queries submitted by one or more users to identify features to suggest to the user based on a likelihood that users who submitted queries similar to the partial query included that feature in the query. The query system then presents to the user the identified features as suggestions to include in the partial query. | 04-04-2013 |
20130044175 | Method and System of Fabricating PZT Nanoparticle Ink Based Piezoelectric Sensor - The disclosure provides in one embodiment a method of fabricating a lead zirconate titanate (PZT) nanoparticle ink based piezoelectric sensor. The method has a step of formulating a lead zirconate titanate (PZT) nanoparticle ink. The method further has a step of depositing the PZT nanoparticle ink onto a substrate via an ink deposition process to form a PZT nanoparticle ink based piezoelectric sensor. | 02-21-2013 |
20130018040 | Compositions And Methods For Treating Toxoplasmosis, Cryptosporidiosis, And Other Apicomplexan Protozoan Related Diseases - Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite | 01-17-2013 |
20130017167 | HYDROPHOBIC BLOCK CONJUGATED THERAPEUTIC AGENTS - Provided herein are polymers having a therapeutic agent covalently coupled to a hydrophobic block thereof, as well as micelles and therapeutic compositions thereof. | 01-17-2013 |
20130014259 | DETECTION OF SPYWARE THREATS WITHIN VIRTUAL MACHINE - A system analyzes content accessed at a network site to determine whether it is malicious. The system employs a tool able to identify spyware that is piggy-backed on executable files (such as software downloads) and is able to detect “drive-by download” attacks that install software on the victim's computer when a page is rendered by a browser program. The tool uses a virtual machine (VM) to sandbox and analyze potentially malicious content. By installing and running executable files within a clean VM environment, commercial anti-spyware tools can be employed to determine whether a specific executable contains piggy-backed spyware. By visiting a Web page with an unmodified browser inside a clean VM environment, predefined “triggers,” such as the installation of a new library, or the creation of a new process, can be used to determine whether the page mounts a drive-by download attack. | 01-10-2013 |
20130011362 | TARGETING MONOMERS AND POLYMERS HAVING TARGETING BLOCKS - Provided herein are monomers incorporating folate or other targeting agent, polymers prepared therefrom, polymers prepared therefrom having a therapeutic agent covalently coupled thereto, as well as micelles and therapeutic compositions thereof. | 01-10-2013 |
20120322939 | CROSSLINKED ZWITTERIONIC HYDROGELS - Zwitterionic crosslinking agents, crosslinked zwitterionic hydrogels prepared from copolymerization of zwitterionic monomers with the zwitterionic crosslinking agent, methods for making crosslinked zwitterionic hydrogels, and devices that include and methods that use the crosslinked zwitterionic hydrogels. | 12-20-2012 |
20120318369 | VIBRATION-DRIVEN DROPLET TRANSPORT DEVICES HAVING TEXTURED SURFACES - Methods and devices for moving a droplet on an elongated track on a textured surface using vibration. The elongated track on the textured surface includes a plurality of transverse arcuate projections such that a droplet on the surface is in the Fakir state and when the surface is vibrated the droplet is urged along the track as a result of an imbalance in the adhesion of a front portion of the droplet and a back portion of the droplet to the textured surface. | 12-20-2012 |
20120315287 | MIC-BINDING ANTIBODIES AND METHODS OF USE THEREOF - The technology described herein relates to antibodies and/or polypeptides which bind to MIC and inhibit MIC shedding. Methods of using such antibodies and/or polypeptides for the treatment of cancer are also described herein. | 12-13-2012 |
20120315239 | ZWITTERIONIC POLYMER BIOCONJUGATES AND RELATED METHODS - Zwitterionic polymer and mixed charge copolymer bioconjugates, methods for making and using the bioconjugates. | 12-13-2012 |
20120290052 | METHODS AND DEVICES FOR BRAIN COOLING FOR TREATMENT AND/OR PREVENTION OF EPILEPTIC SEIZURES - Passive prosthetic devices for focally cooling a brain and methods for inhibiting seizures are disclosed. The prosthetic devices replace a thermally insulating bone flap with a thermally conductive insert having an inner surface that contacts the relatively warm meninges or brain and an outer surface that contacts the relatively cool scalp. In an embodiment, the prosthesis is unitary; in another, a biocompatible casing is filled with a highly conductive core; in another, a filled polymer block is attached to a plate; and in another, the bone flap is filled with a conductive polymer. In one embodiment, a filled polymer containing elements that exhibit the magnetocaloric effect provide heat transfer that can be enhanced by application of a suitable magnetic field. Focal cooling as low as 1.2° C. has been found effective at inhibiting seizures. | 11-15-2012 |
20120272347 | CHITOSAN-ALGINATE SCAFFOLD CELL CULTURE SYSTEM AND RELATED METHODS - Methods for culturing cancer cells in vitro using a three-dimensional scaffold, scaffolds that include the cultured cancer cells, and methods for using the cultured cancer cells and the scaffolds that include the cultured cancer cells in anticancer therapeutic drug development. | 10-25-2012 |
20120269870 | SWITCHABLE POLYMERS AND SURFACES WITH REVERSIBLY SWITCHABLE PROPERTIES - Reversibly switchable polymers, surfaces that include the polymers, and methods for making and using the polymers and surfaces. The switchable polymers are non-fouling in their zwitterionic form and are antimicrobial in their cationic form. | 10-25-2012 |
20120259021 | SELF-ASSEMBLED PARTICLES FROM ZWITTERIONIC POLYMERS AND RELATED METHODS - Zwitterionic block copolymers and zwitterionic conjugates that advantageously self-assemble into particles, particles assembled from the zwitterionic block copolymers and zwitterionic conjugates, pharmaceutical compositions that include the self-assembled particles, and methods for delivering therapeutic and diagnostic agents using the particles. | 10-11-2012 |
20120245408 | METHODS AND SYSTEMS FOR IMPROVING ACTUATOR PERFORMANCE BY REDUCING TENSILE STRESSES IN PIEZOELECTRIC THIN FILMS - Disclosed are methods and systems for improving actuator performance by reducing tensile stresses in piezoelectric thin films. In one embodiment, a piezoelectric actuator includes a substrate, a first electrode positioned on the substrate, a piezoelectric thin film positioned on the first electrode, and a second electrode positioned on the piezoelectric thin film. The displacement capability of the actuator is enhanced by reducing the tensile stresses of the piezoelectric thin film. In some embodiments, a constant DC voltage applied to the piezoelectric actuator generates compressive in-plane stresses, which counteract the tensile in-plane stresses. As a result, the overall tensile stresses in the actuator are reduced, and the actuator displacement is improved. | 09-27-2012 |
20120242999 | INTERFEROMETRIC QUASI-AUTOCOLLIMATOR - Systems and method are disclosed for measuring small angular deflections of a target using weak value amplification. A system includes a beam source, a beam splitter, a target reflecting surface, a photodetector, and a processor. The beam source generates an input beam that is split into first and second beams by the beam splitter. The first and second beams are propagated to the target reflecting surface, at least partially superimposed at the target reflecting surface, and incident to the target reflecting surface normal to the target reflecting surface. The first beam is reflected an additional even number of times during propagation to the photodetector. The second beam is reflected an additional odd number of times during propagation to the photodetector. The first and second beams interfere at the photodetector so as to produce interference patterns. The interference patterns are interpreted to measure angular deflections of the target reflecting surface. | 09-27-2012 |
20120235047 | OPTICAL-INTERFACE PATTERNING FOR RADIATION DETECTOR CRYSTALS - A radiation detector is disclosed that includes a scintillation crystal and a plurality of photodetectors positioned to detect low-energy scintillation photons generated within the scintillation crystal. The scintillation crystals are processed using subsurface laser engraving to generate point-like defects within the crystal to alter the path of the scintillation photons. In one embodiment, the defects define a plurality of boundaries within a monolithic crystal to delineate individual detector elements. In another embodiment, the defects define a depth-of-interaction boundary that varies longitudinally to vary the amount of light shared by neighboring portions of the crystal. In another embodiment the defects are evenly distributed to reduce the lateral spread of light from a scintillation event. Two or more of these different aspects may be combined in a single scintillation crystal. Additionally, or alternatively, similar SSLE defects may be produced in other light-guiding elements of the radiation detector. | 09-20-2012 |
20120232388 | ULTRASOUND SYSTEMS AND METHODS FOR REAL-TIME NONINVASIVE SPATIAL TEMPERATURE ESTIMATION - Ultrasound systems and methods for real-time noninvasive spatial temperature estimation are disclosed herein. A method for noninvasive temperature estimation in accordance with an embodiment of the present technology can include, for example, propagating ultrasound waves into tissue and detecting echoes of the ultrasound waves. The ultrasound waves can become nonlinear as they propagate into the tissue. The method can further include monitoring changes in tissue temperature in real-time using a spectral-based temperature estimation approach, which correlates nonlinear acoustic effects with changes in tissue temperature. | 09-13-2012 |
20120226868 | SYSTEMS AND METHODS FOR PROVIDING DETERMINISTIC EXECUTION - Devices and methods for providing deterministic execution of multithreaded applications are provided. In some embodiments, each thread is provided access to an isolated memory region, such as a private cache. In some embodiments, more than one private cache are synchronized via a modified MOESI coherence protocol. The modified coherence protocol may be configured to refrain from synchronizing the isolated memory regions until the end of an execution quantum. The execution quantum may end when all threads experience a quantum end event such as reaching a threshold instruction count, overflowing the isolated memory region, and/or attempting to access a lock released by a different thread in the same quantum. | 09-06-2012 |
20120226197 | LIMB VOLUME ACCOMMODATION IN PEOPLE WITH LIMB AMPUTATION - A prosthetic sock monitoring system is disclosed. The sock monitoring system includes a storage device and a data collection unit. The data collection unit is operable to receive data from at least one sensor coupled to a prosthetic sock that is wearable by a patient, and store the received data in the storage device. A prosthetic sock is also disclosed. The sock comprises material shaped to fit over at least a portion of the residual limb of the patient and a thickness adapted for inserting the residual limb into the socket of the prosthesis while the sock is fitted over the residual limb. The sock also comprises one or more of a sock identification unit and a force sensing device. | 09-06-2012 |
20120225017 | MIXED MICELLES - This disclosure is directed to mixed micelle compositions for administration of e.g., therapeutic agents or imaging agents to a subject. | 09-06-2012 |
20120191371 | TERAHERTZ SPECTROSCOPY OF ROUGH SURFACE TARGETS - A method and system for analyzing noisy terahertz spectroscopy data transforms the measured time-dependent data into frequency space, for example, using a discrete Fourier transform, and then transforms the frequency spectrum into wavelet frequency space. The twice-transformed data is analyzed to identify spectroscopic features of the signal, for example, to identify a resonance frequency. The method may be used, for example, in a stand-off detector to identify particular chemicals in a target. | 07-26-2012 |
20120190049 | GLYPICAN-3 TARGETING OF LIVER CANCER CELLS USING MULTIFUNCTIONAL NANOPARTICLES - Method for labeling and detecting liver cancer cells using an anti-glycipan-3 antibody as a targeting agent and a magnetic nanoparticle as an imaging agent. | 07-26-2012 |
20120183710 | METHODS FOR BLOW MOLDING SOLID-STATE CELLULAR THERMOPLASTIC ARTICLES - A process for producing cellular thermoplastic articles. The process comprises the steps of treating a solid parison made from a thermoplastic material with a saturating gas at an elevated pressure for a period of time to provide a gas-saturated parison; heating the gas-saturated parison to prepare a cellular parison; placing the cellular parison in a mold; and blowing a molding gas into the cellular parison to expand the cellular parison into the shape of the mold to provide a shaped cellular article. | 07-19-2012 |
20120182520 | Methods for Diagnosing and Treating Eye-Length Related Disorders - The invention provides to methods for diagnosing eye-length related disorders, including myopia. The invention also provides methods for treating and limiting eye-length related disorders, including myopia. In addition, the invention provides certain haplotypes associated with eye-length related disorders, including myopia and Bornholm Eye Disease. | 07-19-2012 |
20120150499 | INVERTIBLE CONTACT MODEL - Methods for computing the inverse dynamics of multibody systems with contacts are disclosed. Inverse dynamics means computing external forces that cause a system to move along a given trajectory. Such computations have been used routinely for data analysis and control synthesis in the absence of contacts between rigid bodies. The disclosed inverse dynamics methods include the ability to handle contacts. The disclosed methods include the following steps: projecting the discrete-time equations of motion from joint space to contact space; defining the forward dynamics in contact space as the solution to an optimization problem; using the features of this optimization problem to obtain a unique inverse—which turns out to correspond to the solution to a dual optimization problem; solving the latter using standard methods for numerical optimization; projecting the solution from contact space back to joint space and finding the external forces. The corresponding methods for computing forward dynamics are also disclosed. | 06-14-2012 |
20120144372 | SYSTEMS AND METHODS FOR FINDING CONCURRENCY ERRORS - Systems and methods for detecting concurrency bugs are provided. In some embodiments, context-aware communication graphs that represent inter-thread communication are collected during test runs, and may be labeled according to whether the test run was correct or failed. Graph edges that are likely to be associated with failed behavior are determined, and probable reconstructions of failed behavior are constructed to assist in debugging. In some embodiments, software instrumentation is used to collect the communication graphs. In some embodiments, hardware configured to collect the communication graphs is provided. | 06-07-2012 |
20120097551 | COPPER-BASED WATER OXIDATION CATALYSTS - Methods for electrolysis of water to oxygen gas are provided. The method utilizes dimeric copper cations in water at a basic pH. The cations are provided in the water by adding a complex in solid form with an appropriate anion, or through a “self-assembly” method whereby a copper salt and appropriate ligands are added to water adjusted to a basic pH. The cations decrease the overpotential of water electrolysis, thereby providing for efficient generations of oxygen gas using a catalyst formed from an abundant material (copper). | 04-26-2012 |
20120079630 | SUB-MICROSECOND-RESOLUTION PROBE MICROSCOPY - Methods and apparatus are provided herein for time-resolved analysis of the effect of a perturbation (e.g., a light or voltage pulse) on a sample. By operating in the time domain, the provided method enables sub-microsecond time-resolved measurement of transient, or time-varying, forces acting on a cantilever. | 03-29-2012 |
20110311499 | Secretion System and Methods for its Use - The present invention provides reagents and methods for inhibiting bacterial infection and abnormal cell growth, as well as for selection cloning of nucleic acid inserts. | 12-22-2011 |
20110305634 | Methods and systems for adenovirus interaction with desmoglein 2 (DSG2) - The present invention provides compositions and methods for treating disorders associated with epithelial tissues. | 12-15-2011 |
20110300186 | Functionalized Nano- and Micro-materials for Medical Therapies - Compositions containing an optionally surface-functionalized mesoporous support and a biologically active agent, and pharmaceutical compositions of the same, are provided herein. Such compositions can be useful in the treatment of tumors, for example, by injection of the composition at a location near the site of the tumor. | 12-08-2011 |
20110278541 | COLOR-SELECTIVE QUANTUM DOT PHOTODETECTORS - Photoconductive optoelectronic devices, such as photodetectors and photovoltaics, are provided. The devices are sensitized to a particular wavelength (or range of wavelengths) of electromagnetic radiation such that the devices provide increased performance efficiency (e.g., external quantum efficiency) at the wavelength. The devices include a photoconductive semiconductor layer spanning an electrode gap between two electrodes to provide a photoconductive electrical conduit. Abutting the semiconductor layer is a plurality of plasmonic nanoparticles. The improved efficiency of the devices results from wavelength-dependent plasmonic enhancement of device photosensitivity by the plasmonic nanoparticles. | 11-17-2011 |
20110191276 | OPEN INFORMATION EXTRACTION FROM THE WEB - To implement open information extraction, a new extraction paradigm has been developed in which a system makes a single data-driven pass over a corpus of text, extracting a large set of relational tuples without requiring any human input. Using training data, a Self-Supervised Learner employs a parser and heuristics to determine criteria that will be used by an extraction classifier (or other ranking model) for evaluating the trustworthiness of candidate tuples that have been extracted from the corpus of text, by applying heuristics to the corpus of text. The classifier retains tuples with a sufficiently high probability of being trustworthy. A redundancy-based assessor assigns a probability to each retained tuple to indicate a likelihood that the retained tuple is an actual instance of a relationship between a plurality of objects comprising the retained tuple. The retained tuples comprise an extraction graph that can be queried for information. | 08-04-2011 |
20110143356 | THERMOSTABLE POLYMERASES HAVING ALTERED FIDELITY AND METHODS OF IDENTIFYING AND USING SAME - The present invention provides a method for identifying a thermostable polymerase having altered fidelity. The method consists of generating a random population of polymerase mutants by mutating at least one amino acid residue of a thermostable polymerase and screening the population for one or more active polymerase mutants by genetic selection. For example, the invention provides a method for identifying a thermostable polymerase having altered fidelity by mutating at least one amino acid residue in an active site O-helix of a thermostable polymerase. The invention also provides thermostable polymerases and nucleic acids encoding thermostable polymerases having altered fidelity, for example, high fidelity polymerases and low fidelity polymerases. The invention additionally provides a method for identifying one or more mutations in a gene by amplifying the gene with a high fidelity polymerase. The invention further provides a method for accurately copying repetitive nucleotide sequences using a high fidelity polymerase mutant. The invention also provides a method for diagnosing a genetic disease using a high fidelity polymerase mutant. The invention further provides a method for randomly mutagenizing a gene by amplifying the gene using a low fidelity polymerase mutant. | 06-16-2011 |
20110117668 | SELF-POWERED SMART DIAGNOSTIC DEVICES - Devices and methods are provided for immobilizing a diagnostic target (e.g., indicative of a disease) from a solution (e.g., a biological fluid). The diagnostic target is first bound to a capture conjugate that includes a reversibly-associative polymer moieties attached to a first binding moiety that binds to the diagnostic target. Once the diagnostic target is bound to the capture conjugate, the solution is subjected to a change in heat and/or pH to cause the reversibly-associative polymer moieties to aggregate. The aggregates are then immobilized (e.g., via filtration). | 05-19-2011 |
20110112772 | TRANSMISSION QUANTIFICATION OF OPEN PATH FTIR SPECTRA WITH TEMPERATURE COMPENSATION - A transmission quantification approach that is effective at quantifying the concentration of key atmospheric gases, including water vapor and methane, does not require a background spectrum and is immune to changes between background and absorbance spectra. By using local minima and maxima in transmission of a target gas, this approach creates two spectral arrays as long as a single beam input spectra. One of these spectral arrays represents the points in wave-number space that are less absorbing points, and the other represents the more absorbing points. A concentration for a given gas is calculated by determining what reference concentration creates a residual after division by a pure gas spectrum that forces these two arrays to converge. | 05-12-2011 |
20100297639 | QUANTITATIVE/SEMI-QUANTITATIVE MEASUREMENT OF EPOR ON CANCER CELLS - The present invention provides for assays useful in predicting whether a cancer patient risks suffering erythropoietin-induced tumor progression if treated with erythropoietin. More specifically, one embodiment provides for a validated quantitative reverse transcriptase polymerase chain reaction assay that detects erythropoietin receptor expression, thus indicating whether a cancer patient risks suffering erythropoietin-induced tumor progression if treated with erythropoietin. | 11-25-2010 |
20100209951 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY - Methods for assaying α-L-iduronidase enzymatic activity and methods for screening newborns for Mucopolysaccharidosis Type-I. | 08-19-2010 |