Class / Patent application number | Description | Number of patent applications / Date published |
435141000 | Propionic or butyric acid | 32 |
20080199926 | Methods and Organisms for Growth-Coupled Production of 3-Hydroxypropionic Acid - The invention provides a non-naturally occurring microorganism having one or more gene disruptions, the one or more gene disruptions occurring in genes encoding an enzyme obligatory coupling 3-hydroxypropionic acid production to growth of the microorganism when the gene disruption reduces an activity of the enzyme, whereby the one or more gene disruptions confers stable growth-coupled production of 3-hydroxypropionic acid onto the non-naturally occurring microorganism. Also provided is a non-naturally occurring microorganism comprising a set of metabolic modifications obligatory coupling 3-hydroxypropionic acid production to growth of the microorganism, the set of metabolic modifications having disruption of one or more genes including: (a) the set of genes selected from: (1) adhE, ldhA, pta-ackA; (2) adhE, ldhA, frdABCD; (3) adhE, ldhA, frdABCD, ptsG; (4) adhE, ldhA, frdABCD, pntAB; (5) adhE, ldhA, fumA, fumB, fumC; (6) adhE, ldhA, fumA, fumB, fumC, pntAB; (7) pflAB, ldhA, or (8) adhE, ldhA, pgi in a microorganism utilizing an anaerobic β-alanine 3-HP precursor pathway; (b) the set of genes selected from: (1) tpi, zwf; (2) tpi, ybhE; (3) tpi, gnd; (4) fpb, gapA; (5) pgi, edd, or (6) pgi, eda in a microorganism utilizing an aerobic glycerol 3-HP precursor pathway; (c) the set of genes selected from: (1) eno; (2) yibO; (3) eno, atpH, or other atp subunit, or (4) yibO, atpH, or other atp subunit, in a microorganism utilizing a glycerate 3-HP precursor pathway, or an ortholog thereof, wherein the microorganism exhibits stable growth-coupled production of 3-hydroxypropionic acid. The disruptions can be complete gene disruptions and the non-naturally occurring organisms can include a variety of prokaryotic or eukaryotic microorganisms. A method of producing a non-naturally occurring microorganism having stable growth-coupled production of 3-hydroxypropionic acid is further provided. The method includes: (a) identifying in silico a set of metabolic modifications requiring 3-hydroxypropionic acid production during exponential growth, and (b) genetically modifying a microorganism to contain the set of metabolic modifications requiring 3-hydroxypropionic acid production. | 08-21-2008 |
20090053783 | 3-HYDROXYPROPIONIC ACID AND OTHER ORGANIC COMPOUNDS - Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed. | 02-26-2009 |
20090075351 | COMPOSITIONS AND METHODS FOR THE BIOSYNTHESIS OF 1,4-BUTANEDIOL AND ITS PRECURSORS - The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce monomeric 4-hydroxybutanoic acid (4-HB). Also provided is a non-naturally occurring microbial biocatalyst including a microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (BDO) biosynthetic pathways, the pathways include at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, 4-hydroxybutyrate:CoA transferase, 4-butyrate kinase, phosphotransbutyrylase, α-ketoglutarate decarboxylase, aldehyde dehydrogenase, alcohol dehydrogenase or an aldehyde/alcohol dehydrogenase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce 1,4-butanediol (BDO). Additionally provided is a method for the production of 4-HB. The method includes culturing a non-naturally occurring microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway including at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase or α-ketoglutarate decarboxylase under substantially anaerobic conditions for a sufficient period of time to produce monomeric 4-hydroxybutanoic acid (4-HB). Further provided is a method for the production of BDO. The method includes culturing a non-naturally occurring microbial biocatalyst, comprising a microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (BDO) biosynthetic pathways, the pathways including at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, 4-hydroxybutyrate:CoA transferase, 4-hydroxybutyrate kinase, phosphotranshydroxybutyrylase, α-ketoglutarate decarboxylase, aldehyde dehydrogenase, alcohol dehydrogenase or an aldehyde/alcohol dehydrogenase for a sufficient period of time to produce 1,4-butanediol (BDO). The 4-HB and/or BDO products can be secreted into the culture medium. | 03-19-2009 |
20090186392 | Anaerobic Fermentation of Glycerol - The invention relates to the development of appropriate cultivation conditions for a bacteria to grow anaerobically (fermentatively) on a glycerol substrate. The method requires culturing bacteria having a functional 1,2-propanediol pathway and a functional type II glycerol dehydrogenase-dihydroxyacetone kinase pathway in a culture medium containing high concentrations of glycerol, a neutral to mildly acidic pH, low levels of potassium and phosphate, and high levels of CO2, such that glycerol is thus converted into a desirable product, such as ethanol, —hydrogen, formate, succinate, or 1,2-propanediol. | 07-23-2009 |
20090275096 | MICROORGANISMS FOR THE PRODUCTION OF METHACRYLIC ACID - The invention provides a non-naturally occurring microbial organism having a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. The method can include culturing a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid producing microbial organism expressing at least one exogenous nucleic acid encoding a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway enzyme in a sufficient amount and culturing under conditions and for a sufficient period of time to produce 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. | 11-05-2009 |
20090325248 | Microbiological Production of 3-Hydroxypropionic Acid - The present invention relates to a cell which is genetically modified in relation to its wild type and which exhibits at least one of the properties a) or b):
| 12-31-2009 |
20100143989 | Production Of 3-Hydroxycarboxylic Acid Using Nitrilase Mutants - This invention relates to nitrilase mutants having improved nitrilase activity for converting 3-hydroxynitriles to 3-hydroxycarboxylic acids. More specifically, the | 06-10-2010 |
20110008856 | Biological Systems for Manufacture of Polyhydroxyalkanoate Polymers Containing 4-Hydroxyacids - The gene encoding a 4-hydroxybutyryl-Co A transferase has been isolated from bacteria and integrated into the genome of bacteria also expressing a polyhydroxyalkanoate synthase, to yield an improved production process for 4HB-containing polyhydroxyalkanoates using transgenic organisms, including both bacteria and plants. The new pathways provide means for producing 4HB containing PHAs from cheap carbon sources such as sugars and fatty acids, in high yields, which are stable. Useful strains are obtaining by screening strains having integrated into their genomes a gene encoding a 4HB-CoA transferase and/or PHA synthase, for polymer production. Processes for polymer production use recombinant systems that can utilize cheap substrates. Systems are provided which can utilize amino acid degradation pathways, α-ketoglutarate, or succinate as substrate. | 01-13-2011 |
20110151529 | METHODS AND PROCESSES FOR PRODUCING ORGANIC ACIDS - A fermentation process for the production of organic acids is provided and includes, providing metabolically engineered mutant bacteria which have had one or both of ack and pta genes disrupted, adapting the mutant bacteria to increase their resistance to acids and to increase their growth rate by immobilizing the mutant bacteria while exposing the mutant bacteria to a fermentable substrate, and further exposing the adapted mutant bacteria to a fermentable substrate for a time sufficient to provide a final organic acid fermentation product concentration of greater than about 50 g/L. | 06-23-2011 |
20120003707 | Method for Injecting a Feed Gas Stream into a Vertically Extended Column of Liquid - A process for conversion of syngas to liquid products that serve as surface acting agents uses the gas stream at a relatively low pressure to eliminate the use of a compressor. The process uses a liquid stream as the primary energy input to a gas injector that intensely mixes gas and the liquid with reduced compression costs while the presence of the liquid product maintains the gas-liquid dispersion as it flows downward to build a static pressure head. The process lowers the required gas pressure by adjusting the elevation of the gas injector such that a conduit receives the gas-liquid dispersion from the outlet of the injector and confines it as it travels downward to enter the bottom of a column of liquid. The liquid product provides a surface acting agent that prolongs the creation and duration of microbubbles in the gas-liquid dispersion. | 01-05-2012 |
20120129232 | POLYHYDROXYALKANOATE PRODUCTION FROM POLYOLS - Organisms are provided which express enzymes such as glycerol dehydratase, diol dehydratase, acyl-CoA transferase, acyl-CoA synthetase β-ketothiolase, acetoacetyl-CoA reductase, PHA synthase, glycerol-3-phosphate dehydrogenase and glycerol-3-phosphatase, which are useful for the production of PHAs. In some cases one or more of these genes are native to the host organism and the remainder are provided from transgenes. These organisms produce poly(3-hydroxyalkanoate)homopolymers or co-polymers incorporating 3-hydroxypropionate or 3-hydroxyvalerate monomers wherein the 3-hydroxypropionate and 3-hydroxyvalreate units are derived from the enzyme catalysed conversion of diols. Suitable diols that can be used include 1,2-propanediol, 1,3 propanediol and glycerol. Biochemical pathways for obtaining the glycerol from normal cellular metabolites are also described. The PHA polymers are readily recovered and industrially useful as polymers or as starting materials for a range of chemical intermediates including 1,3-propanediol, 3-hydroxypropionaldehyde, acrylics, malonic acid, esters and amines. | 05-24-2012 |
20120135481 | Compositions and methods for 3-hydroxypropionic acid production - The present application discloses genetically modified yeast cells comprising an active 3-HP fermentation pathway, and the use of these cells to produce 3-HP. | 05-31-2012 |
20120142064 | RECOMBINANT BACTERIA HAVING THE ABILITY TO METABOLIZE SUCROSE - Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct: a nucleotide sequence from | 06-07-2012 |
20120244588 | METHOD OF PRODUCING 3-HYDROXYPROPIONIC ACID USING MALONIC SEMIALDEHYDE REDUCING PATHWAY - A method of producing 3-hydroxypropionic acid (“3-HP”) with a high yield using a recombinant microorganism having an activity of reducing malonyl CoA into malonic semialdehyde and an activity of reducing malonic semialdehyde into 3-HP and/or an NADPH regeneration activity is provided. | 09-27-2012 |
20130323806 | Recombinant microorganisms and uses therefor - Bacteria are genetically engineered to produce 3-hydroxypropionate (3-HP). The bacteria are carboxydotrophic acetogens. The bacteria produce acetyl-coA using the Wood-Ljungdahl pathway for fixing CO/CO | 12-05-2013 |
20130323807 | 3-HYDROXYPROPIONIC ACID AND OTHER ORGANIC COMPOUNDS - Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed. | 12-05-2013 |
20140093925 | RECOMBINANT MICROORGANISMS FOR PRODUCING ORGANIC ACIDS - Recombinant microorganisms that co express enzymatic glucose-6-phosphate dehydrogenase and malate dehydrogenase are generated to produce organic acids. | 04-03-2014 |
20140178952 | Method for Improving Acid tolerance of Propionibacterium acdipropionici - The invention provides a simple and effective method for improving acid tolerance of | 06-26-2014 |
20140242654 | Butyrate Producing Clostridium species, Clostridium pharus - A clostridia bacterial species | 08-28-2014 |
20140273120 | Method for production of n-propanol and other C3-containing products from syngas by symbiotic co-cultures of anaerobic microorganisms - This invention provides methods and systems for the production of propanol. Specifically, the methods and systems of the present invention use symbiotic co-cultures for the production of propanol from syngas. | 09-18-2014 |
20140273121 | Method for production of n-propanol and other C3-containing products from syngas using membrane supported bioreactor - This invention provides methods for the production of n-propanol. Specifically, the methods and systems of the present invention use symbiotic co-cultures operating in a membrane supported bioreactor for the production of n-propanol from syngas. | 09-18-2014 |
20150044743 | LONG CHAIN ORGANIC ACID BIOPRODUCTION - Method of cell culture, comprising adding a redox active compound with a redox potential of between −0.116 to −0.253 to a culture capable of forming hydrogen via a hydrogenase so that the redox potential is diverted from hydrogen to form a longer chain acids, e.g., butryic acid. | 02-12-2015 |
20150044744 | BIOLOGICAL ALKANE OXIDATION - The invention relates to a method for oxidizing an alkane, comprising contacting the alkane with a type alkB oxidoreductase and using a type alkB oxidoreductase to prepare a mixture of oxidation products of an alkane, wherein the ratio of carboxylic acid to alcohol in the oxidation products is preferably greater than 1:1. | 02-12-2015 |
20150361457 | PROCESSING AND TRANSFORMING BIOMASS - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful intermediates and products, such as energy, fuels, foods or materials. The saccharified biomass is fermented in two steps to form two separate products. The second product can be a carboxylic acid which is reacted with an alcohol to form an ester. The alcohol used for the esterification may be obtained from the biomass. The ester is hydrogenated to alcohols with catalysts. | 12-17-2015 |
20150376658 | MAKING C4+ PRODUCTS IN BACTERIA - Methods of making C4+ hydrocarbon feedstocks using anaerobic microbes are described. | 12-31-2015 |
20160017384 | FERMENTATION BASED ON HYDROLYZED CORN AND/OR SUGAR CANE MASH TO PRODUCE PROPIONIC ACID - A process to prepare propionic acid comprises preparing a fermentation broth of water; at least 30 weight percent hydrolyzed corn mash solids, hydrolyzed sugar cane mash solids, or a combination thereof, based on the combined weight of the fermentation broth as a whole; and | 01-21-2016 |
20160068919 | MICROORGANISM CO-CULTURE SYSTEM AND USES OF THE SAME - A microorganism co-culture system, comprising:
| 03-10-2016 |
20160076111 | FUSANTS CAPABLE OF FIXING CARBON OXIDES AND PERFORMING FERMENTATION AND THE PREPARATION METHOD AND USE OF THE SAME - A microorganism capable of fixing a carbon oxide and performing fermentation and its preparation method and use are provided, wherein the preparation method comprises:
| 03-17-2016 |
20160083755 | CLOSTRIDIUM CADAVERIS STRAIN AND USES OF THE SAME - An isolated | 03-24-2016 |
20160138058 | METHOD FOR PRODUCING ORGANIC COMPOSITIONS FROM OXYHYDROGEN AND CO2 VIA ACETOACETYL-COA AS INTERMEDIATE PRODUCT - The invention relates to a method for producing organic compositions comprising the method steps: A) providing an oxyhydrogen bacterium having an activity of an enzyme E | 05-19-2016 |
20160251684 | UTILIZATION OF INTESTINAL BACTERIA FROM SLAUGHTERED ANIMALS IN INDUSTRIAL PROCESSES AND WASTE TREATMENT | 09-01-2016 |
20170233774 | MICROORGANISM CO-CULTURE SYSTEM AND USES OF THE SAME | 08-17-2017 |