Class / Patent application number | Description | Number of patent applications / Date published |
435446000 | Mutation employing radiation or electricity | 11 |
20080248574 | ANTAGONISTS OF THE INTERACTION OF MELANOMA INHIBITORY ACTIVITY (MIA) AND P66SHC - The invention provides polypeptides, nucleic acids encoding the polypeptides, optionally in a vector, and their use in methods to disrupt the interaction between p66shc and Melanoma Inhibitory Activity (MIA) in a cell and to sensitize a cell to oxidative stress. | 10-09-2008 |
20080248575 | Drug and Gene Delivery by Polymer Nanonozzle and Nanotip Cell Patch - Delivery of drugs or genes to individual cells is achieved on a nanoscale using electroporation techniques. In one method, a flow-through bioreactor having an inlet and an outlet connected by a flow chamber and a nanoporous membrane positioned in the flow chamber is used. Cells to be electroporated are flowed from the inlet to the outlet, a quantum of molecules of the at least one drug or gene in a fluid medium in the flow chamber. An electrical field applied in the flow chamber provides momentum to the molecules in the nanopores, resulting in delivery of the molecules into the plurality of cells. | 10-09-2008 |
20090197335 | METHOD FOR IMPROVED TRANSFER OF DNA INTO LIVING CELLS BY ELECTROPORATION - The subject invention concerns an electroporation buffer that allows for enhanced transfection efficiency and cell viability of cells during application of an electric current. Buffers of the invention provide for maximum transfer of target particles into cells while maintaining the health and growth potential of the cell population. Compositions of the invention comprise electroporation buffers of approximately physiological ionic strength and pH, and having serum or purified proteins, such as serum albumin, added thereto. The subject invention is suitable for use with any cell type. The subject invention also concerns methods of electroporation using an electroporation buffer of the invention. | 08-06-2009 |
20090317911 | SYSTEM AND METHOD FOR PHOTODYNAMIC CELL THERAPY - A method for stimulating, inhibiting, or regulating gene expression including exposing a living cell with at least one gene to an administered source of narrowband, multichromatic electromagnetic radiation. | 12-24-2009 |
20100240131 | Method of modifying the genome of gram-positive bacteria by means of a novel conditionally negative dominant marker gene - The invention relates to a novel method for modifying the genome of Gram-positive bacteria, to these bacteria and to novel vectors. The invention particularly relates to a method for modifying | 09-23-2010 |
20110159591 | Genetic material and chromosomal processing and manipulation methods - The presently claimed invention applies to a genetic material processing and manipulation method and related product. The claimed invention relates to a method for changing the inherited characteristics of a cell through chromosome processing treatment. In a preferred embodiment, ‘genomic surgery’ is applied to source genetic material | 06-30-2011 |
20120196371 | MULTI PLASMIDS SYSTEM FOR THE PRODUCTION OF INFLUENZA VIRUS - Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. In addition, the present invention includes an improved method of rescue, wherein animal cells (e.g., SF Vero cells) are electroporated with plasmids and vectors of the invention. | 08-02-2012 |
20120208277 | NOVEL DNA CLONING METHOD RELYING ON THE E.COLI recE/recT RECOMBINATION SYSTEM - The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with sequence homology to the first DNA molecule. Competent cells and vectors are also described. | 08-16-2012 |
20130078723 | Genetic Material Manipulation Techniques and Products Thereof - The presently claimed invention applies to a genetic material processing and manipulation method and related product. The claimed invention relates to a method for changing the inherited characteristics of a cell through micro-beam chromosome modification. In one preferred embodiment, improvements to ‘genomic surgery’ are applied to modify source cell genetic material ( | 03-28-2013 |
20150072431 | Mature Dendritic Cell Compositions and Methods for Culturing Same - This invention provides methods to prepare and use immunostimulatory cells for enhancing an immune response. The invention provides a method for preparing mature dendritic cells (DCs), comprising the sequential steps of: (a) signaling isolated immature dendritic cells (iDCs) with a first signal comprising an interferon gamma receptor (IFN-γR) agonist and/or a tumor necrosis factor alpha receptor (TNF-αR) agonist to produce signaled dendritic cells; and (b) signaling said signaled dendritic cells with a second transient signal comprising an effective amount of a CD40 agonist to produce CCR7 | 03-12-2015 |
20150093830 | TRANSFORMATION OF ALGAL CELLS - Exemplary methods include a method for transforming an algal cell by preparing a transformation construct, preparing a particle for bombarding the algal cell, adhering the transformation construct to the particle, bombarding the algal cell with the particle, and growing the algal cell into a colony. The transformation construct is replicated within a nuclear genome of the algal cell and the growing of the algal cell is in a nutrient medium. Another exemplary method may include a method for genetically modifying an algal cell, by adding nucleic acid to the algal cell while the algal cell is suspended in a solution of low conductivity, introducing the nucleic acid into the algal cell by application of an electrical pulse resulting in a transformed algal cell, and selecting a colony that includes the transformed algal cell. | 04-02-2015 |