Entries |
Document | Title | Date |
20080274529 | Photoporation Of Cells - An opening is formed in a cell using laser radiation. A Bessel beam is formed using the laser radiation and the Bessel beam is directed onto the cell to form an opening. The guiding of material towards the opening may be involved using optical trapping/manipulation. The material may change cellular function or analyse cell behaviour. Both pulsed laser radiation and continuous wave radiation may be formed using the same laser. | 11-06-2008 |
20080280339 | Cell Training For Local Field Stimulation - A system is provided for stimulating one or more cells, wherein the stimulation is sub-threshold and may alter a transmembrane potential of the one or more cells. For some populations of cells it may be possible to affect the transmembrane potential to gain a therapeutic benefit. Cells of the sino-atrial node spontaneously depolarize predominantly due to the slow depolarization of transmembrane potential. The present system may provide sino-atrial cells with a local field stimulation that while not eliciting an action potential may nonetheless alter local transmembrane potential. Such alteration of transmembrane potential may permit an increase or decrease in a rate of depolarization, and hence modify heart rate. | 11-13-2008 |
20090311767 | Method for molecular delivery into cells using naonotube spearing - The present invention discloses a method of delivering a macromolecule to a cell, comprising engaging the macromolecule to a nanotube wherein the nanotube comprises a magnetic particle, placing the nanotubes into a sample wherein the sample comprises a plurality of cells and applying a force to the sample wherein the force causes the nanotubes to collide with the cells and thereby spear the cells. The method further discloses applying a second force which drives the nanotubes into the cell. Furthermore, the invention discloses a method of transfecting and/or transducing a cell, comprising engaging a macromolecule to a nanotube, placing the nanotubes into communication with the cells and applying a force to the nanotubes which causes the nanotubes to collide with the cells and thereby pierce the cellular membrane. Once inside the cell, the macromolecule may disengage from the nanotube. | 12-17-2009 |
20090325257 | Method for Influencing Living Cells Through Cell-Surface Interaction - The invention relates to a method for influencing living cells through cell-surface interaction where, for the cell-surface interaction, bioactive material is applied to magnetic carrier material, then this magnetic carrier material is applied to a magnetic carrier substrate, and this carrier substrate is combined with the living cells. The magnetic domain arrangement in the substrate can be altered by means of an external magnetic field in such a way that the structure formed by the magnetic carrier material is likewise changed. An in vitro alteration of the structure of the substrate is thus possible. | 12-31-2009 |
20100009424 | Sonoporation systems and methods - The present invention is directed to devices and methods that apply ultrasonic energy for the purpose of inducing transfection and cell transformation. A sonoporation system in accordance with embodiments of the present invention includes an ultrasonic electrical energy generator connected to an ultrasonic transducer producing stress waves. The ultrasonic transducer is connected to a fluid containment tank configured to accept at least a portion of the ultrasonic transducer whereby the ultrasonic stress waves may be delivered into the fluid medium. A cell holder is configured to hold one or more cells desirable for transfection. A hydrophone may be electrically connected to an acoustic stress wave intensity detection circuit. A motion control system having an arm configured to receive one or both of the cell holder and the hydrophone is configured to provide motion of one or both of the cell holder and the hydrophone within the fluid medium. | 01-14-2010 |
20100055756 | System and method for modifying biological cells using an ultra-short pulsed laser - A system and method for modifying a biological cell are presented. A beam of ultra-short pulses is generated. The beam is delivered to a mixture that includes a biological cell and a medium. The beam is focused to form a focal zone. The focal zone may be proximate to the biological cell. An event is generated at the focal zone that effectuates a modification to the biological cell. | 03-04-2010 |
20100227371 | Electrosonic Cell Manipulation Device - In method of injecting a substance into a living cell having a cell membrane, the substance, the cell and a liquid are placed into a tapering passage. Energy is applied to the cell, thereby inducing poration. To sort cells, a cellular suspension is placed in a tapering passage, including a narrow end that defines an opening that has a dimension corresponding to a cell size. An acoustic wave is applied, thereby forcing cells having a cell size smaller than the selected cell size through the opening, with a portion of the cells having a cell size not smaller than the selected cell size not forced through the opening. To extract material from a cell, an electric field and an acoustic wave are applied, thereby causing the cell membrane to allow the material to pass out of the cell. | 09-09-2010 |
20100255557 | ELECTRICALLY CONTROLLED ION TRANSPORT DEVICE - A device for electrically controlled transport of ions between a source and a target electrolyte, including: a first source electrode and a first target electrode, each capable of conducting ions and electrons, wherein the source electrode is arranged to receive ions from the source electrolyte and the target electrode is arranged to release ions to the target electrolyte. | 10-07-2010 |
20110306108 | APPARATUS AND METHOD FOR LIVING CELL MANIPULATION - The present invention provides a method and system for using eye-safe infrared energy from a Class I laser to manipulate cells in culture. The laser energy produces one or more phase boundary propulsion events, which generate hydrodynamic forces sufficient to manipulate cells at the focal point. | 12-15-2011 |
20120077245 | METHOD AND DEVICE FOR THE ELECTRICAL TREATMENT OF REACTION SPACES - The invention relates to a method for applying at least one electrical voltage pulse to at least one reaction space by at least partially discharging at least one charge storing unit for storing electrical charges. According to the invention the method comprises applying at least one voltage pulse to a reaction space by at least partially discharging a second charge storing unit and simultaneously charging or partially discharging a first charge storing. Furthermore, the invention relates to a device | 03-29-2012 |
20120214218 | TRANSFECTION WITH MAGNETIC NANOPARTICLES AND ULTRASOUND - The invention includes a magnetic nanoparticle molecular delivery vehicle to be used for transfection and delivery of therapeutic molecules across cell membranes and to specific sites in the body, using magnetic forces and ultrasound. | 08-23-2012 |
20130224821 | Light-Activated Chimeric Opsins and Methods of Using the Same - Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons. | 08-29-2013 |
20130295635 | System for Optical Stimulation of Target Cells - Various systems and methods are implemented for controlling stimulus of a cell. One such method is implemented for optical stimulation of a cell expressing a NpHR ion pump. The method includes the step of providing a sequence of stimuli to the cell. Each stimulus increases the probability of depolarization events occurring in the cell. Light is provided to the cell to activate the expressed NpHR ion pump, thereby decreasing the probability of depolarization events occurring in the cell. | 11-07-2013 |
20140093932 | DEVICES, SYSTEMS, AND METHODS FOR THE FABRICATION OF TISSUE UTILIZING UV CROSS-LINKING - Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink, and support material; a UV light module for optionally exposing the contents of at least one cartridge to UV light; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Also described herein are methods of using and bioprinting cartridges for such bioprinters. | 04-03-2014 |
20150368632 | CRYSTALLINE MATERIALS ON BIOLOGICAL TISSUE AND METHODS FOR MAKING THE SAME - Provided are compositions including a direct interface between a biological tissue and a crystalline material, wherein the crystalline material has a crystallization temperature that exceeds the temperature at which the biological tissue incurs thermal damage. Also provided are methods for producing said compositions. The ability to apply crystalline materials to biological tissues has wide applicability, e.g., with cyborg applications. Extensive challenges exist, however, in applying crystalline materials to biological tissue substrates. | 12-24-2015 |
20160168561 | ORGANIC DEVICES FOR THE PHOTOINHIBITION OF EXCITABLE CELLS | 06-16-2016 |
20160194624 | SYSTEM FOR OPTICAL STIMULATION OF TARGET CELLS | 07-07-2016 |
20160377572 | Cephalopod Proteins as Proton Conductors - The disclosed invention relates to novel materials and associated methods for conducting protons, such materials comprising cephalopod proton-conducting proteins such as reflectins. The protonic conductivity of such cephalopod proton-conducting proteins may be modulated by the application of an electric field. The invention further encompasses protonic transistors comprising a cephalopod proton-conducting protein channel. The transistors and related devices of the invention are amenable to use in biological systems for the sensing or manipulation of protonic flows within the biological system. | 12-29-2016 |