Class / Patent application number | Description | Number of patent applications / Date published |
436173000 | NUCLEAR MAGNETIC RESONANCE, ELECTRON SPIN RESONANCE OR OTHER SPIN EFFECTS OR MASS SPECTROMETRY | 54 |
20080206887 | METHODS FOR IDENTIFICATION AND QUANTIFICATION OF MULTICOMPONENT-FLUID AND ESTIMATING FLUID GAS/ OIL RATIO FROM NMR LOGS - A method for determining a proportion of a hydrocarbon constituent in a mixture including at least one hydrocarbon, includes determining at least one nuclear magnetic resonance (NMR) property for at least one hydrocarbon constituent in the mixture; correlating an NMR response for the property for each hydrocarbon constituent in the mixture; and from the correlating, calculating the proportion of at least the constituent. A computer program product is also provided. | 08-28-2008 |
20080241955 | Methods, Mixtures, Kits And Compositions Pertaining To Analyte Determination - This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination by mass spectrometry using labeling reagents that comprise a nucleophilic reactive group that reacts with a functional group of an analyte to produce a labeled analyte. The labeling reagents can be used as isobaric sets, mass differential labeling sets or in a combination of isobaric and mass differential labeling sets. | 10-02-2008 |
20080274563 | DETECTING SUCCINYLACETONE - This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry. | 11-06-2008 |
20080305555 | Methods, Compositions and Devices For Performing Ionization Desorption on Silicon Derivatives - A device for the presentation of samples for MALDI or DIOS ion source, comprising a semiconductor wafer body having at least one first surface and at least one second surface, the first surface being chemically modified to repel said aqueous sample toward said second surface. | 12-11-2008 |
20090170215 | Selection of non-small-cell lung cancer patients for treatment with monoclonal antibody drugs targeting EGFR pathway - Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a non-small-cell lung cancer (NSCLC) patient is likely to benefit from a monoclonal antibody drug targeting an epidermal growth factor receptor pathway. A mass spectrum is obtained from a sample (e.g. blood sample) from the patient. One or more predefined pre-processing steps are performed on the mass spectrum. Values of selected features in the spectrum at one or more predefined m/z ranges are obtained after the pre-processing steps have been performed. Such values are used in a classification algorithm using a training set comprising class-labeled spectra produced from samples from other patients to identify the patient as being likely to benefit from treatment with the drug. | 07-02-2009 |
20090170216 | Selection of colorectal cancer patients for treatment with drugs targeting EGFR pathway - Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a colorectal cancer (CRC) patient is likely to benefit from a drug targeting an epidermal growth factor receptor pathway, such as monoclonal antibody EGFR inhibitors. | 07-02-2009 |
20100062539 | SILICA PARTICLES MODIFIED WITH POLAR ORGANIC MOIETIES - The present disclosure relates to silica particles and, in embodiments, to organically-substituted silica particles. The particles are useful for the adsorption of compounds, particularly the adsorption and desorption of compounds in for example matrix assisted mass spectroscopy techniques or chromatographic techniques. The present disclosure further relates to such techniques, the preparation of the particles and other subject matter. | 03-11-2010 |
20100173424 | Method for Detecting a Target Substance by Nuclear magnetic Resonance - A method for detecting a known target substance in a sample by means of nuclear magnetic resonance (NMR) of a preselected nuclear species contained in the target substance is described. The method comprises the steps of: a) providing a starting sample known or suspected to contain the target substance; b) adding to the starting sample an amount of isotope-labeled target substance, thus obtaining a composite sample, the isotope-labeled target substance being obtainable from the target substance by replacing at least one nucleus thereof by another isotope thereof, wherein said replacing induces a change in the position or multiplicity of at least one NMR signal of the target substance; c) acquiring NMR signals of the preselected nuclear species from the composite sample; d) determining actual positions of an auxiliary set of NMR signals of the isotope-labeled target substance; e) calculating actual positions of a principal set of NMR signals of the target substance from the actual positions of the auxiliary set of signals and from a predetermined relationship between relative positions of the signals of the isotope-labeled target substance and of the signals of the target substance, f) detecting at least one signal of the target substance located at an actual position calculated by step e). | 07-08-2010 |
20100178710 | Mass Labels - A mass label for labelling and detecting a biological molecule by mass spectroscopy, which label comprises the following structure: X-L-M wherein X is a mass marker moiety comprising the following group: formula (I), wherein the cyclic unit is aromatic or aliphatic and comprises from 0-3 double bonds independently between any two adjacent atoms; each Z is independently N, N(R | 07-15-2010 |
20100248388 | Solid Phase Extraction and Ionization Device - A plate for laser desorption ionization mass spectrometry comprising an electrically conductive substrate ( | 09-30-2010 |
20100291704 | Method of Inorganic Analysis by Mass Spectrometry - A method of inorganic analysis by mass spectrometry comprises treating a surface with a chelating reagent so that inorganic elements can be made volatile and desorbed directly from the surface, exposing the volume over the surface or a swab wiping the surface to a flow of metastable atoms and molecules at atmospheric pressure to ionize volatile compounds, and passing the ionized volatile compounds to a mass spectrometer or the like. | 11-18-2010 |
20110053287 | METHODS FOR THE DIAGNOSIS, RISK ASSESSMENT, AND MONITORING OF AUTISM SPECTRUM DISORDERS - Methods for the diagnosis, risk assessment, and monitoring of Autism Spectrum Disorder (ASD) are disclosed. More specifically the present invention relates to the measurement of small molecules (metabolites) in human plasma that are found to have different abundances between persons with a clinical manifestation of ASD and subjects not expressing symptoms of ASD. Further, this invention relates to the monitoring of putative therapeutic strategies designed to ameliorate the biochemical abnormalities associated with ASD. | 03-03-2011 |
20110059546 | METHOD AND APPARATUS FOR CONVERSION OF MULTIPLE ANALYTE CATION TYPES TO A SINGLE ANALYTE ANION TYPE VIA ION/ION CHARGE INVERSION - An apparatus and method for a sample using a mass spectrometer is described, including, generating ions of a first polarity from an analyte using electrospray ionization; generating ions of a second polarity from a reagent; injecting the ions of the first polarity and ions of the second polarity in sequence into a chamber of the mass spectrometer such that the ions of the first polarity and the ions of the second polarity interact in the chamber to form analyte ions having the second polarity; and, analyzing the mass spectrum of the analyte ions of the second polarity. A reagent such as a polyamidomine is selected to preferentially yield analyte ions of the second polarity having a desired mass-to-charge ratio. | 03-10-2011 |
20110091987 | Miniaturized Magnetic Resonance Systems and Methods - The present application describes devices, systems, and techniques related to a chip-based, miniaturized NMR diagnostic platform for rapid, quantitative and multi-channeled detection of biological targets. | 04-21-2011 |
20110143451 | Method of Operating a Reagent Ion Source - A method is disclosed for operating a chemical ionization-type (CI-type) source to generate reagent ions for mass spectrometry experiments, such as electron transfer dissociation (ETD) reagent ions. The method includes periodically reversing current flow in the thermionic filament employed to produce the electron stream. Periodic reversal of the filament current avoids or reduces the problem of carbonaceous growth formation associated with prior art reagent ion sources. | 06-16-2011 |
20110165694 | Method for Quantitatively Identifying a Substance by Mass Spectrometry - The invention relates to a method for the quantitative determination of a chemical substance S from a sample using a mass spectrometer having at least one detector. In line with the invention, a sample which may contain the substance S of interest, or a conversion product of the sample, is analyzed in the mass spectrometer. For the analysis the mass spectrometer is alternately set at least for masses SM | 07-07-2011 |
20110183430 | GROUP SPECIFIC INTERNAL STANDARD TECHNOLOGY (GSIST) FOR SIMULTANEOUS IDENTIFICATION AND QUANTIFICATION OF SMALL MOLECULES - Reagents and methods are provided that permit simultaneous analysis of multiple diverse small molecule analytes present in a complex mixture. Samples are labeled with chemically identical but isotopically distinct forms of the labeling reagent, and analyzed using mass spectrometry. A single reagent simultaneously derivatizes multiple small molecule analytes having different reactive functional groups. | 07-28-2011 |
20110183431 | MASS ANALYSIS SYSTEM WITH LOW PRESSURE DIFFERENTIAL MOBILITY SPECTROMETER - A mass analysis system including a low pressure dissociation region and a differential mobility spectrometer. The differential mobility spectrometer including at least one pair of filter electrodes defining an ion flow path where the filter electrodes generate an electric field for passing through a selected portion of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, an ion inlet that receives sample ions that have passed through the low pressure dissociation region, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions. | 07-28-2011 |
20110189788 | Glow Discharge Ion Source - A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode ( | 08-04-2011 |
20110287554 | ATMOSPHERIC PRESSURE ION SOURCE PERFORMANCE ENHANCEMENT - Electrospray ionization sources interfaced to mass spectrometers have become widely used tools in analytical applications. Processes occurring in Electrospray (ES) ionization generally include the addition or removal of a charged species such as H+ or other cation to effect ionization of a sample species Electrospray includes ionization processes that occur in the liquid and gas phase and in both phases ionization processes require a source or sink for such charged species. Electrolyte species, that aid in oxidation or reduction reactions occurring in Electrospray ionization, are added to sample solutions in many analytical applications to increase the ion signal amplitude generated in Electrospray and detected by a mass spectrometer (MS). Electrolyte species that may be required to enhance an upstream sample preparation or separation process may be less compatible with the downstream ES processes and cause reduction in MS signal. New Electrolytes have been found that increase positive and negative polarity analyte ion signal measured in ESMS analysis when compared with analyte ESMS signal achieved using more conventional electrolytes. The new electrolyte species increase ES MS signal when added directly to a sample solution or when added to a second solution flow in an Electrospray membrane probe. It has also been found that running the ES membrane probe with specific Electrolytes in the second solution of the ES membrane probe have been found to enhance ESMS signal compared to using the same electrolytes directly in the sample solution being Electrosprayed. The new electrolytes can be added to a reagent ion source configured in a combination Atmospheric pressure ion source to improve ionization efficiency. | 11-24-2011 |
20110306147 | Method of Multiple Spiking Isotope Dilution Mass Spectrometry - A comprehensive approach for interpretation of the multiple spiking isotope dilution results is described herein. It has now been found that a method of multiple spiking isotope dilution analysis for mass spectrometry is possible using an approach that permits precise and simultaneous characterization of m substances from a sample even if species inter-conversion (degradation and formation) has occurred prior to separation. Advantageously, initial and final amounts of involved analytes, conversion extent, conversion degree and rate constants from the results of a single quantitation experiment may be obtained with the present method. In a particularly advantageous embodiment, uncertainty in the characterization of the substances may be estimated more accurately by also estimating increase in the uncertainty due to interconversion of the analytes. | 12-15-2011 |
20120003748 | Chemical Ionization Reaction or Proton Transfer Reaction Mass Spectrometry - A system and methods are described for generating reagent ions and product ions for use in a mass spectrometry system. Applications for the system and method are also disclosed for detecting volatile organic compounds in trace concentrations. A microwave or high-frequency RF energy source ionizes particles of a reagent vapor to form reagent ions. The reagent ions enter a chamber, such as a drift chamber, to interact with a fluid sample. An electric field directs the reagent ions and facilitates an interaction with the fluid sample to form product ions. The reagent ions and product ions then exit the chamber under the influence of an electric field for detection by a mass spectrometer module. The system includes various control modules for setting values of system parameters and analysis modules for detection of mass and peak intensity values for ion species during spectrometry and faults within the system. | 01-05-2012 |
20120115242 | VITAMIN D METABOLITE DETERMINATION UTILIZING MASS SPECTROMETRY FOLLOWING DERIVATIZATION - The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry. | 05-10-2012 |
20120149125 | Ion Population Control for an Electrical Discharge Ionization Source - A method of providing reagent ions to a mass spectrometer comprises delivering a reagent species to a reagent ionization volume via a passageway at a flow rate. Using previously acquired information, an injection time duration is calculated for injecting reagent ions that are formed in the reagent ionization volume into a reaction region of the mass spectrometer. A determination is made as to whether the calculated injection time duration is within a specified range of injection time duration values. When it is determined that the calculated injection time duration falls outside of the specified range of injection time duration values, the flow rate at which the reagent species is delivered to the ionization volume is adjusted. | 06-14-2012 |
20120156798 | DETERMINATION OF CORES OR BUILDING BLOCKS AND RECONSTRUCTION OF PARENT MOLECULES IN HEAVY PETROLEUMS AND OTHER HYDROCARBON RESOURCES - A method for the determination of the aromatic cores or building blocks of a vacuum resid by controlled fragmentation. Molecules can be generated from these building blocks. | 06-21-2012 |
20120208289 | Mass Spectrometer - A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained. | 08-16-2012 |
20120264227 | ANALYTE EXTRACTION AND ANALYSIS - Apparatus and methods are disclosed for the collection and analysis of analytes from samples. In one embodiment an extraction chamber is provided that includes a sample holder and an extraction lid that allows for simultaneous multifiber solid phase microextraction of analytes from a sample held in the sample holder. Methods of collection and analysis include using simultaneous multifiber solid phase microextraction of analytes from a sample. | 10-18-2012 |
20130011930 | METHOD OF ANALYZING MICROPARTICLE COMPOSITION AND MICROPARTICLE COMPOSITION ANALYZING DEVICE - A method of analyzing microparticle compositions and a microparticle composition analyzing device are capable of quantitatively analyzing the mass concentration of air microparticles online for each chemical composition. The particle ray of microparticles in an air sample is converged, and is irradiated onto a narrow domain of a capture body which includes a mesh-shaped structure for capturing the microparticles in the particle ray while removing surplus gas phase components, and the microparticles are captured. Then, the narrow region is subjected to concentrated irradiation of energy rays, and the microparticles that are captured by the capture body are vaporized, sublimated or reacted to yield a desorbed component, which is analyzed. | 01-10-2013 |
20130065320 | METHODS FOR THE ASSESSMENT OF COLORECTAL CANCER AND COLORECTAL POLYPS BY MEASUREMENT OF METABOLITES IN URINE - Methods for the diagnosis of CRC, colorectal polyps in general and adenomatous polyps in particular by measurement of metabolites in urine are described. In some embodiments, certain metabolites are identified as being elevated or reduced in concentration or quantity in subjects with CRC and/or colorectal polyps as compared with subjects without CRC or colorectal polyps. The measurement of these metabolites in urine can indicate the presence of CRC or colorectal polyps in general or adanomatous polyps in particular in a subject. | 03-14-2013 |
20130078732 | METHODS FOR DIAGNOSING IMPENDING JOINT FAILURE - The invention provides methods for diagnosing impending joint failure in an animal by measuring the concentration of phenylalanine in a body fluid; measuring the concentration of one or more of tyrosine, alanine, valine, and glutamine in the body fluid; determining the ratio of phenylalanine to one or more of tyrosine, alanine, valine, and glutamine; and diagnosing impending joint failure by comparing the ratio to ratios predicative of impending joint failure. | 03-28-2013 |
20130084645 | GAS-PHASE PURIFICATION FOR ACCURATE ISOBARIC TAG-BASED QUANTIFICATION - Described herein are mass spectrometry systems and methods which improve the accuracy of isobaric tag-based quantification by alleviating the pervasive problem of precursor interference and co-isolation of impurities through gas-phase purification. During the gas-phase purification, the mass-to-charge ratios of precursor ions within at least a selected range are selectively changed allowing ions having similar unmodified mass-to-charge ratios to be separated before further isolation, fragmentation or analysis. | 04-04-2013 |
20130084646 | QUANTIFYING ELEMENTAL SULFUR IN LIQUID HYDROCARBONS - The present disclosure relates to a novel GC/MS/MS method for quantifying levels of elemental sulfur in hydrocarbons, including crude petroleum, petroleum products, and liquefied hydrocarbon gases. | 04-04-2013 |
20130115711 | REACTANTS FOR CHARGE TRANSFER REACTIONS IN MASS SPECTROMETERS - The invention relates to the use of substances for the production of anions suitable for charge transfer reactions in mass spectrometers, particularly for the fragmentation of multiply positively charged biopolymer ions by electron transfer or for charge reduction by proton transfer. Diketones, particularly α-diketones, are proposed as a newly found class of substances which can be used both for the production of radical anions for electron transfer dissociations (ETD) with a high yield of fragment ions and also for the production of non-radical anions for the charge reduction of multiply charged analyte ions by proton transfer reactions (PTR). These substances have favorable properties in terms of their handling and the associated analytical methods: they are largely nontoxic, cover a favorable range of molecular masses, and their volatility means that they can be stored in unheated containers outside of the vacuum system, which facilitates the refilling of the containers. | 05-09-2013 |
20130203180 | Chemical Ionization Reaction or Proton Transfer Reaction Mass Spectrometry - A system and methods are described for generating reagent ions and product ions for use in a mass spectrometry system. Applications for the system and method are also disclosed for detecting volatile organic compounds in trace concentrations. A microwave or high-frequency RF energy source ionizes particles of a reagent vapor to form reagent ions. The reagent ions enter a chamber, such as a drift chamber, to interact with a fluid sample. An electric field directs the reagent ions and facilitates an interaction with the fluid sample to form product ions. The reagent ions and product ions then exit the chamber under the influence of an electric field for detection by a mass spectrometer module. The system includes various control modules for setting values of system parameters and analysis modules for detection of mass and peak intensity values for ion species during spectrometry and faults within the system. | 08-08-2013 |
20130210162 | ATMOSPHERIC PRESSURE LASER-INDUCED ACOUSTIC DESORPTION CHEMICAL IONIZATION FOR GLOBAL HYDROCARBON ANALYSIS - Systems, devices, and methods, operational at atmospheric pressure, involving a conical member having an outlet positioned relative to an inlet of a mass spectrometer inlet capillary; a tungsten electrode positioned between the conical member and the inlet of the mass spectrometer inlet capillary; a foil membrane disposed within the conical member, the foil membrane having a first surface, and a second surface opposed to the first surface; a laser directing laser pulses at the second surface of the foil membrane to create a shockwave to vaporize one or more analytes deposited on the first surface; a reagent gas inlet stream positioned relative to the foil membrane to pass a reagent gas across the foil member to transport vaporized analytes: away from the foil membrane, through the outlet of the conical member, through a corona discharge generated by the tungsten electrode, and into the inlet capillary of a mass spectrometer. | 08-15-2013 |
20130236983 | Oilfield Chemicals with Attached Spin Probes - Detecting a spin probe in an oilfield fluid may indicate or determine the amount of the particular chemicals within an oilfield fluid. The detection of the spin probe may also indicate at least one property of the oilfield fluid, such as but not limited to pH, dielectric constant, rotational freedom of the spin probe, at least one chemical, the concentration of at least one chemical, residue of at least one chemical in the fluid, the speciation of coupled chemistry between the spin probe and the chemical, and combinations thereof. In one non-limiting embodiment, the spin probe may be attached to at least one chemical. The oilfield fluid may be or include, but is not limited to, a drilling fluid, a completion fluid, a production fluid, a servicing fluid, and combinations thereof. | 09-12-2013 |
20130260473 | IONISATION METHOD FOR A UNIVERSAL GAS ANALYZER - The invention provides a method and system for analyzing a gas for the presence of a reactant compound via reaction of primary ions of a specific type. A source gas is introduced to a reaction chamber and ionized in this chamber. The pressure in the reaction chamber is adjusted to avoid the formation of protonated species and other impurities. The primary ions generated in the reaction chamber are transferred to a drift tube. The gas to be analyzed is diluted with a carrier gas and the resulting mixture is introduced into the drift tube. The ionization energy of the carrier gas is equal to or higher than the ionization energy of the primary ions. The product ions resulting in the drift tube from a reaction of the primary ions with the reactant present in the gas to be analyzed are then detected, for example using a mass spectrometer. Preferably, an existing PTR-MS setup is used to perform the method of the present invention. | 10-03-2013 |
20130267036 | LONGEVITY OF HYPERPOLARIZED ENHANCED SIGNALS FOR 'H NMR SPECTROSCOPY - A method and system for providing an article of manufacture with increased longevity of hyperpolarized | 10-10-2013 |
20130267037 | MASS SPECTROMETER DEVICE AND METHOD USING SCANNED PHASE APPLIED POTENTIALS IN ION GUIDANCE - An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser. The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the ion guide or mass analyser in order to urge ions along the length of the ion guides or mass analyser. The amplitude of the transient DC voltage applied to the electrode may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser in reverse order of their mass to charge ratio. | 10-10-2013 |
20130280819 | SYNCHRONIZATION OF ION GENERATION WITH CYCLING OF A DISCONTINUOUS ATMOSPHERIC INTERFACE - The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface. | 10-24-2013 |
20140024132 | METHODS AND SYSTEMS USING INTEGRATED METABOLOMICS AND PHARMACOKINETICS FOR MULTI-COMPONENT DRUG EVALUATION - Disclosed are methods and systems for identifying biochemical changes in a subject in response to administration of a multi-component therapeutic and one or more active ingredients in the multi-component therapeutic. The methods and systems of the invention may be used to elucidate the interaction of the biological system's genome with its environments, and in the pharmacokinetic, pharmacodynamic and toxicology analysis of multi-component therapeutics. The metabolomics methods and systems of the invention can also be used in studies of plant derived agents to demonstrate biochemical alterations in response to the dynamic multi-component intervention. | 01-23-2014 |
20140045273 | METHODS AND APPARATUS FOR IDENTIFICATION OF POLYMERIC SPECIES FROM MASS SPECTROMETRY OUTPUT - Methods and apparatus are provided for the identification of one or more candidate chemical formulas from mass spectrometry data corresponding to an unidentified chemical compound. By restricting the generation of candidate formulas to those having repeating units and/or end units with specified limitations, the methods and apparatus may more efficiently iteratively search for a chemical formula having matching mass spectrometry output within a threshold tolerance. In another aspect, methods and apparatus are provided for the identification of one or more candidate chemical formulas from mass spectrometry data based at least in part upon neutral loss. | 02-13-2014 |
20140051180 | SYNCHRONIZATION OF ION GENERATION WITH CYCLING OF A DISCONTINUOUS ATMOSPHERIC INTERFACE - The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface. | 02-20-2014 |
20140051181 | Glow Discharge Ion Source - A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode located within an isolation valve, which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode, which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions. | 02-20-2014 |
20140087478 | MASS SPECTROMETER INTERFACE - A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions. | 03-27-2014 |
20140099730 | MAGIC ANGLE SPINNING NUCLEAR MAGNETIC RESONANCE APPARATUS AND PROCESS FOR HIGH-RESOLUTION IN SITU INVESTIGATIONS - A continuous-flow (CF) magic angle sample spinning (CF-MAS) NMR rotor and probe are described for investigating reaction dynamics, stable intermediates/transition states, and mechanisms of catalytic reactions in situ. The rotor includes a sample chamber of a flow-through design with a large sample volume that delivers a flow of reactants through a catalyst bed contained within the sample cell allowing in-situ investigations of reactants and products. Flow through the sample chamber improves diffusion of reactants and products through the catalyst. The large volume of the sample chamber enhances sensitivity permitting in situ | 04-10-2014 |
20140179020 | Methods and Apparatus for Identifying Ion Species Formed during Gas-Phase Reactions - A method for matching each of a plurality of progenitor ion types to respective product or fragment ion types, comprising: generating the plurality of progenitor ion types over a time range by ionizing compounds eluting during the time range using an atmospheric pressure ion source; generating the product or fragment ion types within a pressure range of 750 mTorr to atmospheric pressure in an ionization chamber or first vacuum chamber; detecting abundances of the plurality of progenitor ion types and the product or fragment ion types using a mass analyzer; calculating a plurality of extracted ion chromatograms (XICs) relating to the detected abundances; automatically detecting and characterizing chromatogram peaks within each XIC; automatically generating synthetic analytical fit peaks; performing cross-correlation score calculations between each pair of synthetic analytical fit peaks; and recognizing matches based on the cross correlation scores. | 06-26-2014 |
20140287522 | Pulsed Admission of Analyte to Detection Apparatus - A detecting method using an IMS apparatus with a preconcentrator outside its inlet aperture. Analyte vapor is adsorbed during a first phase when substantially no gas is admitted to the reaction region. The preconcentrator is then energized to desorb the analyte molecules and create a volume of desorbed molecules outside the IMS housing. Next, a pressure pulser is energized momentarily to drop pressure in the housing and draw in a small sip of the analyte molecules from the desorbed volume through the aperture. This is repeated until the concentration of analyte molecules in the desorbed volume is too low for accurate analysis, following which the apparatus enters another adsorption phase. | 09-25-2014 |
20140302616 | METHOD AND DEVICE FOR DETERMINING PROPERTIES OF GAS PHASE BASES OR ACIDS - Properties, such as concentrations, of gas phase bases or acids of a gas sample are determined by providing a sample gas flow, which includes the bases or acids to be determined as sample constituents, as well as also interfering constituents, which are other constituents than the sample constituents. Reagent ions are provided and introduced into the sample gas flow to arrange proton transfer reaction and thereby forming sample ions. Also a dopant is introduced into the sample gas flow to arrange proton transfer reaction between the dopant and the interfering ions thereby forming dopant ions and electrically neutral interfering constituents. For determination the gas flow with the sample ions to be determined is introduced together with the dopant ions to a mass spectrometer in order to determine the properties of the gas phase bases or acids. | 10-09-2014 |
20140322817 | Mass Spectrometer - A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained. | 10-30-2014 |
20150024510 | PERFORMING CHEMICAL REACTIONS AND/OR IONIZATION DURING GAS CHROMATOGRAPHY-MASS SPECTROMETRY RUNS - A gas chromatography-mass spectrometry (GC-MS) method that includes performing a first GC-MS run on a sample using a gas chromatography-mass spectrometry system. Performing the first GC-MS nm includes i) passing a first flow of a carrier gas carrying a first portion of the sample through a gas chromatograph to provide a first effluent; ii) generating first ions under protonation conditions by passing the first effluent through an atmospheric pressure ionization source; iii) passing the first ions through a mass spectrometer; and iv) recording first GC-MS data for the first ions. The method also include performing a second GC-MS run on the sample using the gas chromatography-mass spectrometry system. | 01-22-2015 |
20150293058 | ACCURATE AND INTERFERENCE-FREE MULTIPLEXED QUANTITATIVE PROTEOMICS USING MASS SPECTROMETRY - Embodiments are directed to a method, a computer readable medium encoded with instructions that, when executed, perform a method, and a system for performing mass spectrometry analysis. Molecules of different samples may be labeled with a chemical tag, allowing a multiplexed analysis of multiple samples. The labeled molecules may be fragmented, each fragmented molecule creating at least two separate ions. The relative abundance of each of the heavier ions, which may comprise the original molecule from the sample, may be measured. A relative abundance of the labeled molecules in each of the samples may be determined from the measured relative abundances of the heavier ions. | 10-15-2015 |
20160046643 | HIGHLY EFFICIENT POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION - The invention relates to compounds of general formula (I) wherein X is C═O or SO | 02-18-2016 |
20160195480 | NON AQUEOUS SOLVENTS OR MIXTURES FOR DNP NMR SPECTROSCOPY, METHOD TO PREPARE SAID SOLVENTS OR MIXTURES AND USE OF SAID SOLVENTS OR MIXTURES | 07-07-2016 |