Entries |
Document | Title | Date |
20080221114 | 2-(Cyclic Aminocarbonyl) Indoline Derivative and Medicinal Composition Containing the Same - A compound of the following formula (I): | 09-11-2008 |
20080227791 | Piperidin-4-Yl-Pyridazin-3-Ylamine Derivatives as Fast Dissociating Dopamine 2 Receptor Antagonists - The present invention relates to compounds that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. | 09-18-2008 |
20080234280 | Use of Mc4 Receptor Agonist Compounds - This invention relates to the use of an MC4 receptor agonist compound for the manufacture of a medicament for the treatment of lower urinary tract dysfunction. | 09-25-2008 |
20080242671 | INHIBITORS OF CATHEPSIN S - The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. | 10-02-2008 |
20080255134 | Cardiotonic Compounds With Inhibitory Activity Against Beta-Adrenergic Receptors And Phosphodiesterase - The present invention provides compounds of formula (I) possessing inhibitory activity against β adrenergic receptors and phosphodiesterase (PDE), including type 3 phosphodiesterase (PDE-3). The present invention further provides pharmaceutical compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for regulating calcium homeostasis, for treating a disease, disorder or condition in which disregulation of calcium homeostasis is implicated and for treating cardiovascular disease, stroke, epilepsy, an ophthalmic disorder or migraine. | 10-16-2008 |
20080269233 | Piperidinoyl-Pyrrolidine and Piperidinoyl-Piperidine Compounds - The present invention relates to a class of compounds of general formula (I) | 10-30-2008 |
20080269234 | INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE - Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed. | 10-30-2008 |
20080269235 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AS PDE4 INHIBITORS - New pyridazin-3(2H)-one derivatives having the chemical structure of general formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of phosphodiesterase 4. | 10-30-2008 |
20080306080 | NEUTROPHILIA INHIBITOR - To provide an antineutrophilia agent effective for treatment of development and progress of acute infections, collagen diseases (chronic rheumatoid arthritis, Wegener's granulomatosis and Behcet's disease), chronic obstructive pulmonary disease (COPD), chronic bronchitis, pulmonary emphysema, small airway disease, gout, Cushing's syndrome, myelofibrosis, neoplastic neutrophilia, polycythemia vera and diseases caused by administration of steroid drugs. | 12-11-2008 |
20090005392 | CRYSTAL OF 6-[4-(4-PYRIDYLAMINO) PHENYL]-4,5-DIHYDRO-3(2H-PYRIDAZINONE HYDROCHLORIDE TRIHYDRATE - The present invention provides crystals of 6-[4-(4-pyridylamino)phenyl]-4,5-dihydro-3(2H)-pyridazinone hydrochloride trihydrate useful as a medicament for therapeutic treatment of cardiac failure, and the like; and a pharmaceutical composition comprising said crystals as an active ingredient. | 01-01-2009 |
20090036459 | Melanocortin Type 4 Receptor Agonist Piperidinoylpyrrolidines - The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) | 02-05-2009 |
20090042896 | PYRROLIDINE ARYL-ETHER AS NK3 RECEPTOR ANTAGONISTS - The invention relates to a compound of formula I | 02-12-2009 |
20090062295 | Pharmaceutical Products - Pharmaceutical products comprising 6-[4-(4-pyridylamino)phenyl]-4,5-dihydro-3(2H)-pyridazinone or a salt thereof, or a hydrate thereof or a solvate thereof as an active ingredient, wherein production of hydrazine is substantially suppressed is provided. | 03-05-2009 |
20090082359 | 5-PYRIDINONE SUBSTITUTED INDAZOLES - 5-pyridinone substituted indazoles of the formula | 03-26-2009 |
20090105267 | OCTAHYDRO-PYRROLO[3,4-B]PYRROLE N-OXIDES - The invention relates to octahydro-pyrrolo[3,4-b]pyrrole N-oxides as prodrugs of CNS-active compounds, compositions comprising such compounds, methods for making the compounds, salts, and polymorphs, and methods of treating conditions and disorders using such compounds and compositions. Octahydro-pyrrolo[3,4-b]pyrrole N-oxides of formula (I) are prodrugs of histamine-3 antagonists, and are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole N-oxide compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein. | 04-23-2009 |
20090137601 | L-Phenylalanine Derivatives - The present invention relates to compounds that inhibit of a5b1 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm blooded animals such as humans of diseases that have a significant angiogenesis or vascular component such as for treatment of solid tumours. The present invention also relates to compounds that inhibit a5b1, and also that exhibit appropriate selectivity profile(s) against other integrins. | 05-28-2009 |
20090247534 | NEW COMPOUNDS - The present invention provides organic compounds of the following structure; | 10-01-2009 |
20100048578 | HYDRAZIDE COMPOUND AND HARMFUL ARTHROPOD-CONTROLLING AGENT CONTAINING THE SAME - Disclosed is a hydrazine compound represented by the formula (1) below, which has an excellent control activity against a harmful arthropod. (1) (In the formula, R | 02-25-2010 |
20100048579 | PYRIDAZINE-, PYRIDINE- AND PYRANE-DERIVATIVES AS GPBAR1 AGONISTS - A compound of formula (I) wherein the substituents have various meanings, optionally in salt and/or solvate form, and their use as pharmaceuticals. | 02-25-2010 |
20100056535 | Inhibitors of HIV-1 reverse transcriptase - The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to Formulae I and II | 03-04-2010 |
20100063058 | 4-ALKOXYPYRIDAZINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS - The present invention relates to (1-benzyl-piperidin-4-yl)-(4-alkoxy-pyridazin-3-y1)-amines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. | 03-11-2010 |
20100075975 | MEDICAMENT FOR THE ENHANCEMENT OF COGNITIVE FUNCTION AND NEUROPROTECTION - The invention relates the use of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazole-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H) pyridazinone of the Formula (I) | 03-25-2010 |
20100113465 | 7-AZASPIRO[3.5]NONANE-7-CARBOXAMIDE COMPOUNDS - Provided herein are 7-azaspiro[3.5]nonane-7-carboxamide compounds and the pharmaceutically acceptable salts of such compounds useful in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity, conditions including including acute pain, chronic pain, neuropathic pain, nociceptive pain, inflammatory pain, cancer and cancer pain, fibromyalgia, rheumatoid arthritis, inflammatory bowel disease, lupus, diabetes, allergic asthma, vascular inflammation, urinary incontinence, overactive bladder, emesis, cognitive disorders, anxiety, depression, sleeping disorders, eating disorders, movement disorders, glaucoma, psoriasis, multiple sclerosis, cerebrovascular disorders, brain injury, gastrointestinal disorders, hypertension, or cardiovascular disease. | 05-06-2010 |
20100113466 | OXAZOLE-PYRIDAZINE-OXAZOLE ALPHA-HELIX MIMETIC - There are provided alpha helix scaffolds mimicking i, i+3/i+4, i+7 or i+11 residues having the general structure oxazole-pyridazine-piperidine or oxazole-pyridazine-oxazole. The common pyridazine heterocycle originates from substituted or unsubstituted dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate. These scaffolds are synthetic counterparts of amphiphilic alpha helices having a hydrophilic face along one side and a hydrophobic face along the other side of the helix. | 05-06-2010 |
20100197697 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS - The present invention relates to a compounds of formula I | 08-05-2010 |
20100204240 | Pyridin-2-YL-Amino-1, 2, 4-Thiadiazole Derivatives as Glucokinase Activators for the Treatment of Diabetes Mellitus - Provided are compounds of Formula (I): wherein R | 08-12-2010 |
20100317669 | NOVEL SUBSTITUTED PIPERIDYL-PROPANE-THIOLS - One object of the present invention are novel substituted piperidyl-propane-thiols of the formula (1), wherein R | 12-16-2010 |
20100317670 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN - The present invention discloses a compound of formula: | 12-16-2010 |
20100324058 | THROMBIN FUNCTION COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS BASED ON THEM - This invention relates to new chemical compounds, application of these compound as thrombin inhibitors, and pharmaceutical compositions based on them, and can be used to treat and prevent thrombin-dependent thromboembolic events, and in research. | 12-23-2010 |
20110003826 | ANTICOAGULANT COMPOUNDS, PHARMACEUTICAL COMPOSITIONS ON THEIR BASIS TO TREAT THROMBOTIC CONDITIONS, AND PLASMA-SUBSTITUTING SOLUTION TO CORRECT HYPERCOAGULATION DEFECTS OF HEMODILUTION - This invention relates to new chemical compounds, application of these compounds as anticoagulants, pharmaceutical compositions, and plasma-substituting solutions on their basis, and can be used for treating thromboembolic complications of diseases such as myocardial infarction, stroke, and thrombosis of deep veins or a pulmonary artery; and for preventing hypercoagulation conditions in consequence of injuries, surgeries, sepsis, various obstetric pathologies, in disaster medicine, resuscitation, and so on. | 01-06-2011 |
20110015202 | IMIDAZOLES - The present invention relates to imidazole derivatives of the general formula | 01-20-2011 |
20110021531 | OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH - The present invention is directed to certain oxazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer Disease, and Parkinson's Disease. | 01-27-2011 |
20110053948 | PYRROLIDINES AS NK3 RECEPTOR ANTAGONISTS - The present invention relates to a compounds of formula I | 03-03-2011 |
20110053949 | 4-[3-(ARYLOXY)BENZYLIDENE]-3-METHYL PIPERIDINE ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS - The present invention relates to compounds of Formula (I), wherein Ar is optionally substituted phenyl or heteroaryl and X, Y and Z are independently N or CH; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity. | 03-03-2011 |
20110053950 | 4-BENZYLIDENE-3-METHYLPIPERIDINE ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS - The present invention relates to compounds of Formula (I) wherein Ar is optionally substituted phenyl or heteroaryl; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity. | 03-03-2011 |
20110059979 | Piperidine/Cyclohexane Carboxamide Derivatives For Use as Vanilloid Receptor Modulators - Certain compounds of formula (I), | 03-10-2011 |
20110112108 | PYRIDAZINE FUNGICIDES - The present invention relates to novel pyridazine derivatives of formula (I) as active ingredients which have microbiocidal activity, in particular fungicidal activity: wherein R | 05-12-2011 |
20110144118 | ANTIVIRAL SALTS - This invention relates to antiviral agents, in particular to salts useful in the treatment of infections caused by Picornaviridae, such as human rhinovirus (HRV) and methods for their preparation. The invention also relates to the use of these salts in the treatment of picornavirus infections. The salts of this invention are especially suitable for use in the treatment of HRV, however it is to be understood that the invention is also applicable to other viruses of the picornavirus family. | 06-16-2011 |
20110144119 | OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH - The present invention is directed to certain oxazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease. | 06-16-2011 |
20110230493 | 1-OXA-8-Azaspiro [4,5] Decabe-8-Carboxamide Compounds as FAAH Inhibitors - Provided herein are 1-oxa-8-azaspiro[4.5]decane-8-carboxamide compounds of formula I | 09-22-2011 |
20110257191 | Hydrazine-Substituted Anthranilic Acid Derivatives - The present invention constitutes new hydrazine-substituted anthranilic acid derivatives of the general formula (I), | 10-20-2011 |
20110257192 | COMPOUND FOR TREATMENT OF RESPIRATORY CONDITION OR DISEASE - The present invention relates to the treatment, alleviation, prevention or reduction of symptoms or exacerbations of asthma or chronic obstructive pulmonary disease (COPD), of which reduced lung function is typically symptomatic. | 10-20-2011 |
20110269769 | IMIDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH - The present invention is directed to certain imidazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease. | 11-03-2011 |
20110269770 | Pyrazole Compounds for Controlling Invertebrate Pests - The present invention relates to pyrazole compounds of formulae I or II and the salts and N-oxides thereof, | 11-03-2011 |
20110269771 | PYRIDAZINONE DERIVATIVES - Compounds of the formula (I), in which D, R | 11-03-2011 |
20110288100 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN - The present invention discloses a compound of formula: | 11-24-2011 |
20120010212 | METHYL-PYRROLIDINE ETHER DERIVATIVES - The invention relates to a compound of formula | 01-12-2012 |
20120022073 | COMPOUND FOR THE TREATMENT OF ENTEROVIRUSES - The present invention relates to the treatment, alleviation, prevention or reduction in the incidence of symptoms, diseases or conditions resulting from or associated with enteroviruses, more particularly the enteroviral infections they cause. | 01-26-2012 |
20120028986 | 2-HETEROARYL-PYRROLO [3,4-C]PYRROLE DERIVATIVES, AND USE THEREOF AS SCD INHIBITORS - The invention relates to compounds of the formula (I), where the groups R1, M, A, B, D, L, and R have the specified meanings, and to the physiologically compatible salts thereof. The compounds are suitable, for example, for treating metabolic syndrome, insulin resistance, obesity, and diabetes. | 02-02-2012 |
20120028987 | Bicyclic Benzamides of 3-Or-4-Substituted 4-(Aminomethyl)-Piperidine Derivatives - The present invention of compounds of formula (I) | 02-02-2012 |
20120028988 | USE OF PYRIDAZINONE COMPOUND FOR CONTROL OF HARMFUL ARTHROPOD PESTS - Since a pyridazinone compound shown by formula (I) has an activity for controlling arthropod pests, the pyridazinone compound is effective for a use for controlling arthropod pests. | 02-02-2012 |
20120059014 | Compounds for the Treatment of Metabolic Disorders - The present invention is directed to therapeutic compounds of the following formula (I) | 03-08-2012 |
20120095012 | TOLUIDINE SULFONAMIDES AND THEIR USE - The present invention provides compounds of formula (I), wherein R | 04-19-2012 |
20120142695 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS - Compounds of the formula I | 06-07-2012 |
20120165338 | NEW BIARYL AMIDE DERIVATIVES - The invention provides novel compounds having the general formula (I) | 06-28-2012 |
20120165339 | CYCLOPROPANE DERIVATIVES - A cyclopropane derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof has orexin receptor inhibitory action, and thus, is extremely useful as an agent for preventing or treating sleep disorder or dyssomnia caused by orexin, including insomnia as a typical example: | 06-28-2012 |
20120178761 | PYRROLIDINE DERIVATIVES - The invention provides compounds of formula | 07-12-2012 |
20120208823 | New Compounds - Disubstituted tetrahydrofuranyl compounds of general formula I | 08-16-2012 |
20120277242 | Pyridin-2YL-Amino-1, 2, 4-Thiadiazole Derivatives as Glucokinase Activators for the Treatment of Diabetes Mellitus - Provided are compounds of Formula (I): wherein R | 11-01-2012 |
20120316177 | EXTENDED RELEASE PREPARATION - Disclosed is a sustained release preparation which releases a poorly soluble medicinal agent in a pH-independent manner. Also disclosed is a sustained release preparation which is capable of controlling the C | 12-13-2012 |
20130005736 | ANTIVIRAL AGENTS - This invention relates to compounds of formula I | 01-03-2013 |
20130018054 | NEW COMPOUNDS - The present invention provides organic compounds of the following structure; A-L1-B—C-D-L2-E that are useful for treating or preventing conditions or disorders associated with DGAT1 activity in animals, particularly humans. | 01-17-2013 |
20130030000 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PAIN AND OTHER INDICATIONS - The present invention is directed to a composition useful for the treatment of a FAAH mediated disease, disorder or conditions comprising a FAAH inhibitor and a second activation, comprising a selected imidazole or oxazole FAAH inhibitor and a second active agent. The compositions will be useful in the treatment of a wide range of disease, disorder, or conditions including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer disease, and Parkinson's disease. In another aspect the invention discloses herein is directed to compositions useful in the treatment of neuropathic and nociceptive pain, said compositions comprising etoricoxib. | 01-31-2013 |
20130065906 | New compounds, pharmaceutical compositions and uses thereof - The present invention relates to compounds of general formula I, | 03-14-2013 |
20130065907 | 5-CYCLOALKYL- OR 5-HETEROCYCLYL-NICOTINAMIDES - The present invention relates to compounds of the formula | 03-14-2013 |
20130090341 | HETEROCYCLIC COMPOUNDS - The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof. | 04-11-2013 |
20130123267 | 1-PYRIDAZINYL-HYDROXYIMINO-3-PHENYL-PROPANES - This invention relates to 1-pyridazinyl-hydroxyimino-3-phenyl-propanes of the formula | 05-16-2013 |
20130131075 | NEW COMPOUNDS - The present invention relates to the compounds of general formula I | 05-23-2013 |
20130150373 | NICOTINIC RECEPTOR COMPOUNDS - Provided herein are compounds and methods of preparation of compounds that are capable of functioning as agonists or antagonists of a nicotinic receptor. Also provided are pharmaceutical compositions comprising one or more of these compounds, which may further comprise one or more additional therapeutic agents. Further provided are methods of treatment of various conditions that may be responsive to such activity at the nicotinic receptors, such as nicotine dependence. | 06-13-2013 |
20130184284 | DIAMINOCYCLOHEXANE COMPOUNDS AND USES THEREOF - The present invention provides compounds of Formula (I): | 07-18-2013 |
20130197007 | Phenyl-Heteroaryl Derivatives and Methods of Use Thereof - The present invention provides phenyl-heteroaryl derivatives of Formula (I) and pharmaceutically acceptable salts thereof | 08-01-2013 |
20130203763 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS - The new pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases especially against c-Met and are useful in treating disorders related to abnormal protein kinase activities such as cancer. | 08-08-2013 |
20130237545 | PYRIDAZINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING COGNITIVE IMPAIRMENT - This invention relates to pyridazine derivatives, compositions comprising therapeutically effective amounts of those pyridazine derivatives and methods of using those derivatives or compositions in treating central nervous system (CNS) disorders with cognitive impairment that are responsive to agonists of α5 subunit containing GABA | 09-12-2013 |
20130261128 | CONTINUOUS ARYCYCLIC COMPOUND - This is to provide a continuous arycyclic compound having a DGAT1 inhibitory activity, and useful for prophylaxis and/or treatment of obesity or hyperlipidemia caused by obesity, hypertriglyceridemia, lipid metabolism disorder, fatty liver, hypertension, arteriosclerosis, diabetes, etc., as well as to provide a DGAT1 inhibitor comprising the continuous arycyclic compound or a pharmaceutically acceptable salt thereof as an effective ingredient. Disclosed is the continuous arycyclic compound is represented by the formula: wherein the substituents in the formula are the same as defined in the specification, or a pharmaceutically acceptable salt thereof. | 10-03-2013 |
20130267529 | INDOLE, INDAZOLE AND BENZIMIDAZOLE ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS - Compounds of the formula I: | 10-10-2013 |
20130310393 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS - Disclosed are heteroaryl compounds of Formula (I), (I), or pharmaceutically acceptable salts thereof, wherein Z is CH or N; W is CR | 11-21-2013 |
20140038977 | PYRIDAZIN DERIVATIVES AS ANTAGONISTS OF THE BRADYKININ B1 RECEPTOR - The present invention relates to the compounds of general formula I | 02-06-2014 |
20140057920 | SUBSTITUTED 4-PYRIDONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY - This invention relates to substituted 4-pyridones of formula 1 | 02-27-2014 |
20140080837 | Sanglifehrin Derivatives and Methods for Their Production - There are provided inter alia compounds of formula (I) and (II) | 03-20-2014 |
20140113907 | PYRIDYLAMINOACETIC ACID COMPOUND - The present invention provides a pyridylaminoacetic acid compound represented by the following formula (1): | 04-24-2014 |
20140171437 | OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH - The present invention is directed to certain oxazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease. | 06-19-2014 |
20140179710 | ANTIVIRAL SALTS - This invention relates to antiviral agents, in particular to salts useful in the treatment of infections caused by Picornaviridae, such as human rhinovirus (HRV) and methods for their preparation. The invention also relates to the use of these salts in the treatment of picornavirus infections. The salts of this invention are especially suitable for use in the treatment of HRV, however it is to be understood that the invention is also applicable to other viruses of the picornavirus family. | 06-26-2014 |
20140235646 | Methods and Compositions for the Treatment of Body Weight Related Disorders - The present invention relates to methods for reducing body weight in an animal in need thereof via administration of a therapeutically effective amount of a compound having a general tripartite structure A-B-C. In the tripartite structure A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. The methods may utilize particular compounds, for example, having a piperidinyl, a pyrrolinyl or pyridinyl A ring, a thiazole B ring, and a phenyl C ring which may be further substituted independently. Also provided are methods for increasing thermogenesis without reducing lean body mass during weight loss in an animal by administering of a therapeutically effective amount of the compounds described. | 08-21-2014 |
20140235647 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS - Disclosed are azaindazole compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: X is O and Y is N; or X is S and Y is CH; Z is CR | 08-21-2014 |
20140243349 | GAMMA-DIKETONES AS WNT/BETA -CATENIN SIGNALING PATHWAY ACTIVATORS - The present disclosure provides γ-diketones or analogs thereof, that activate Wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases. | 08-28-2014 |
20140275100 | PYRIDAZINE DERIVATIVES USEFUL IN THERAPY - The invention provides compounds of formula I, (I) wherein: R represents a cyclic group selected from phenyl, heteroaryl, heterocyclyl and C 3-6 cycloalkyl; 10 wherein each cyclic group is optionally substituted with from 1 to 3 substituents selected from halo, C -6 alkyl optionally substituted with 1-3 halogen atoms, phenyl, C -6 alkoxy optionally substituted with 1-3 halogen atoms, cyano, heteroaryl 1a and heterocyclyl 1a; and wherein each cyclic group is optionally fused to a benzene ring or a 5- or 16-membered heteroaromatic or heterocyclic ring each containing from 1 to 3 heteroatoms (selected from N, O and S); and when the group is substituted the substitution may occur anywhere on the optionally fused ring system as a whole; and wherein heterocyclyl and heterocyclyl 1a may additionally be substituted with ═O; 20 X represents a bond or C -6 alkylene (which may be straight or branched); R 2 represents H or C -6 alkyl; R 3 represents H or C -6 alkyl; Y represents a bond or C -6 alkylene (which may be straight or branched, and optionally substituted with OH or CF 3); 2 R 4 represents a cyclic group selected from phenyl, heteroaryl 4, heterocyclyl 4 and C 3-6 cycloalkyl; wherein each cyclic group is optionally substituted with from 1 to 3 substituents selected from halo, C -6 alkyl optionally substituted with 1-3 halogen atoms, TET01063WO 4 phenyl, C -6 alkyl substituted with phenyl, C -6 alkoxy optionally substituted with -3 halogen atoms, cyano, heteroaryl 4a and heterocyclyl 4a; and wherein each cyclic group is optionally fused to benzene ring or a 5- or 6-membered heteroaromatic or heterocyclic ring each containing from 1 to 3 heteroatoms (selected from N, O and S); and when the group is substituted the substitution may occur anywhere on the optionally fused ring system as a whole; and wherein heterocyclyl 4 and heterocyclyl 4a may additionally be substituted with ═O; heteroaryl, heteroaryl 1a, heteroaryl 4 and heteroaryl 4a independently represent a 5- or 6-membered heteroaryl group containing from 1 to 3 heteroatoms (selected from N, O and 10 S); and heterocyclyl, heterocyclyl 1a, heterocyclyl 4 and heterocyclyl 4a independently represent a 5- or 6-membered heterocyclyl group containing from 1 to 3 heteroatoms (selected from N, O and S); and pharmaceutically acceptable salts and solvates thereof.1 The compounds are useful as pharmaceuticals, particularly in the treatment of fibrotic diseases, cancer and pain. | 09-18-2014 |
20140296245 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS - This invention is directed to benzensulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of sodium channel-mediated diseases or conditions, such as pain. | 10-02-2014 |
20140303174 | Pyridazine derivatives as EAAT2 Activators - Pyridazine derivatives that activate the excitatory amino acid transporter 2 (EAAT2), and methods of use thereof for treating or preventing diseases, disorders, and conditions associated with glutamate excitotoxicity. | 10-09-2014 |
20140315912 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS - The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and methods of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor. (I). | 10-23-2014 |
20140315913 | SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS - The invention provides a chemical entity of Formula (I) | 10-23-2014 |
20150057288 | PEST CONTROL AGENTS FOR HONEYBEE PARASITIC PESTS, AND PEST CONTROL METHOD FOR HONEYBEE PARASITIC PESTS USING THE PEST CONTROL AGENTS - A pest control method for honeybee parasitic pests has been found, which is highly safe to honeybees and demonstrates excellent pest control effects against honeybee parasitic pests by using a honeybee parasitic pest control agent containing at least one of a compound represented by Formula (I) and acid addition salts thereof. | 02-26-2015 |
20150065516 | NEW BIARYL AMIDE DERIVATIVES - The invention provides novel compounds having the general formula (I) | 03-05-2015 |
20150065517 | NEW COMPOUNDS - The present invention provides organic compounds of the following structure; | 03-05-2015 |
20150126516 | PIPERIDINE COMPOUND AND ITS USE IN PEST CONTROL - A piperidine compound represented by the following Formula (1): | 05-07-2015 |
20150141432 | PIPERIDIN-4-YL-PYRIDAZIN-3-YLAMINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS - The present invention relates to compounds that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. | 05-21-2015 |
20150322018 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE - Provided are compounds of Formula I: | 11-12-2015 |
20150329500 | SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS - The invention provides a chemical entity of Formula (I) | 11-19-2015 |
20150376131 | SUBSTITUTED 4-PYRIDONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY - This invention relates to substituted 4-pyridones of formula 1 | 12-31-2015 |
20160010158 | COMPOSITIONS AND METHODS OF TREATING CANCER HARBORING PIKC3A MUTATIONS | 01-14-2016 |
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20160081337 | FUNGICIDAL AMIDES - Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, | 03-24-2016 |
20160096823 | AMINOPYRIDYLOXYPYRAZOLE COMPOUNDS - The present invention relates to novel aminopyridyloxypyrazole compounds that inhibit the activity of transforming growth factor beta receptor 1 (TGFβR1), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, preferably colon cancer, melanoma, hepatocellular carcinoma, renal cancer, glioblastoma, pancreatic cancer, myelodysplastic syndrome, lung cancer, and gastric cancer, and/or fibrosis, preferably liver fibrosis and chronic kidney disease. | 04-07-2016 |
20160130254 | NOVEL CYP17 INHIBITORS/ANTIANDROGENS - Compounds of formula (I) | 05-12-2016 |
20160184285 | PIPERIDINE UREA DERIVATIVES - Compounds of the formula I | 06-30-2016 |
20160194310 | ANHYDROUS CRYSTALLINE FREE BASE FORM OF 6--3-ETHOXY-1,2-BENZISOXAZOLE | 07-07-2016 |