Entries |
Document | Title | Date |
20080221208 | Retinal Derivatives and Methods for the Use Thereof for the Treatment of Visual Disorders - Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided. | 09-11-2008 |
20080269326 | Use of 1-Phenyl-3-Dimethylamino-propane Compounds for Treating Neuropathic Pain - Use of 1-phenyl-3-dimethylaminopropane compounds for the production of medicaments for treating neuropathic pain, preferably polyneuropathic pain, also preferably diabetic neuropathic pain, more preferably diabetic peripheral neuropathic pain, and furthermore preferably for treating diabetic peripheral neuropathy. | 10-30-2008 |
20080312320 | Non-dusty, free flowing, storage stable solid composition and a process for its preparation - A solid water dispersible granular composition of pesticide comprising up to 50% of at least one pesticide from pyrethroid class, more particularly a highly viscous liquid pyrethroid insecticide, permethrin, having the properties of excellent dispersibility and suspensibility, as well as the process of preparation of the composition are disclosed. Also the improved storage stability, dispersibility and suspensibility properties are discussed for this granular composition. | 12-18-2008 |
20080319064 | DEUTERIUM-ENRICHED OSELTAMIVIR - The present application describes deuterium-enriched oseltamivir, pharmaceutically acceptable salt forms thereof, and methods of treating using the same. | 12-25-2008 |
20080319065 | Systemic and Intrathecal Effects of a Novel Series of Phospholipase A2 Inhibitors on Hyperalgesia and Spinal Pge2 Release - Phospholipase A | 12-25-2008 |
20090012159 | HIGH PURITY BASES OF 3,3-DIPHENYLPROPYLAMINO MONOESTERS - The invention relates to a compound of general formula (I) wherein A represents deuterium or hydrogen, R represents a group selected from C | 01-08-2009 |
20090042979 | Novel Statin Pharmaceutical Compositions and Related Methods of Treatment - The invention provides novel omega-3 oil formulations of one or more statins. These formulations are readily bioavailable. Notably, because the formulations of the invention contain an omega-3 oils as the major ingredient, they not only provide an antihypercholesterolemic effect due to the statin active ingredient, they also provide recommended daily dosages of omega-3 oils (i.e., approximately 1 gram of omega-3 oil per day), or a portion thereof. The invention also provides novel salts of one or more statins. | 02-12-2009 |
20090054520 | OXALIC ACID DERIVATIVES AND USE THEREOF AS PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS - The present invention relates to specific oxalic acid derivatives and to corresponding mixtures and to uses thereof as physiological cooling active ingredients. | 02-26-2009 |
20090105336 | Beneficial Effects of Increasing Local Blood Flow - The present invention provides a treatment for enhancing the ability of the body to heal wounds. A topical cream is described which improves blood flow by the transdermal delivery of the nitric oxide precursor L-Arginine either alone or with an adjunct, theophylline. The delivery of the active agents is accomplished by use of a vehicle which contains a hostile biophysical environment which is also hostile to hydrogen bond formation. | 04-23-2009 |
20090118366 | ORGANIC COMPOUNDS - A compound of formula (I) | 05-07-2009 |
20090131519 | Use of Growth Regulators for Reducing or Preventing the Contamination of Plants and Vegetable Products by Trichothecene-Producing Mould Toxins - The present invention relates to the use of growth regulators selected from acylcyclohexanedione derivatives and quaternary ammonium compounds for reducing or preventing the contamination of plants and plant products with mycotoxins formed by trichothecene-producing fungi. | 05-21-2009 |
20090176877 | OSELTAMIVIR PHOSHATE GRANULE AND PREPARATION METHOD THEREOF - The present invention relates to an oseltamivir phosphate granule and preparation method thereof. The said granule comprises 1.97-19.8 wt. % oseltamivir phosphate, 75.0-97.5 wt. % diluent, 0.1-5.0 wt. % binder, optionally 1.0-5.0 wt. % edible flavouring essence, sweetener and/or edible pigment. It is prepared by using 30-55 v/v % aqueous ethanol solution as moistening agent. The granules prepared by the formulation and method according to the present invention have good uniformity and stability and are water-soluble. The administration dosage of the granules can be conveniently selected based on the age and body weight of patients. The oseltamivir phosphate granule is suitable for administering to old people, children and flu gravis patients and those patients that swallow inconveniently or difficulty. The preparation of the granule is simple and low in production cost. | 07-09-2009 |
20090298935 | Production And Use Of A Gaseous Vapor Disinfectant - Smoke or vapor generating system disperses an airborne biocidal oil, such as methyl soyate, to decontaminate and area or object. The airborne forms of methyl soyate are have broad spectrum efficacy against a wide variety of microscopic pathogens including viruses, bacteria and fungi. | 12-03-2009 |
20090326063 | SYNTHETIC TRITERPENOIDS AND METHODS OF USE IN THE TREATMENT OF DISEASE - The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis. | 12-31-2009 |
20100035986 | METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION - A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C | 02-11-2010 |
20100035987 | PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES - A pleuromutilin derivative compound of general formula (I) | 02-11-2010 |
20100076077 | ESTERS OF 4,5-DISUBSTITUTED-OXY-2-METHYL-3,6-DIOXO-CYCLOHEXA-1,4-DIENYL ALKYL ACIDS AND PREPARATION THEREOF - Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids. | 03-25-2010 |
20100099760 | Glycyrrhetinic Acid Derivatives - The present invention relates to novel derivatives of glycyrrhetinic acid, compositions comprising said derivatives and their use in the treatment of conditions or diseases that benefit from an upregulation of PPAR&ggr; and/or a downregulation of the expression or activity of one or more specificity (Sp) proteins, such as cancer, diabetes and Huntington's disease. | 04-22-2010 |
20100160431 | Methods and Compositions for the Treatment of Viral Infections - Compositions for treating flu comprise an M2 inhibitor, and optionally a neuraminidase inhibitor, wherein at least one of said M2 inhibitor or said neuraminidase inhibitor is provided in an extended release dosage form. | 06-24-2010 |
20100184855 | Hard Surface Cleaner Compositions of Sulfonated Estolides and Other Derivatives of Fatty Acids and Uses Thereof - Sulfo-estolides and formulations of sulfo-estolides in and as hard surface cleaners, glass cleaners, toilet bowl cleaners, carpet cleaners, all purpose cleaners, floor cleaners, and others are described. Further details of cleaning performance, stability of diluted and concentrated forms and contemplated cleaning applications are provided. | 07-22-2010 |
20100216876 | ANTIDIARRHETIC COMPOSITION, PRODUCT CONTAINING THE SAME AND METHOD OF PREVENTING DIAHHREA - An antidiarrhetic composition is provided which is efficacious against diarrhea, in particular, the predominant secretory diarrhea; an antidiarrhetic medicinal composition containing the same is also provided; a food containing the antidiarrhetic composition is also provided; and a method of preventing diarrhea using the same is also disclosed. The composition for relieving diarrhea is a cool composition capable of acting on the digestive tract in the recipient's body and inhibiting the secretion of the intestinal Cl | 08-26-2010 |
20100222427 | PHARMACEUTICAL COMPOSITION COMPRISING OSELTAMIVIR PHOSPHATE - The present invention provides a pharmaceutical composition comprising: one or more excipients selected from sugars and sugar alcohols in which equilibrium water content is 1% by weight or less at 25° C. and at 70% relative humidity; and oseltamivir phosphate, wherein an amount of each of glucose and mannose contained in the sugars and sugar alcohols as impurities is 0.01% by weight or less. | 09-02-2010 |
20100234458 | Process for the Production of Fatty Acid Alkyl Esters - Disclosed is an improved process for the production of fatty acid lower alkyl esters according to formula (I) | 09-16-2010 |
20100286266 | Biphenyl-4-yl-sulfonic acid arylamides and their use as therapeutic agents - The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl sulfonamides and related compounds (collectively referred to herein as ‘BPSAAA compounds’), as described herein, and including, for example, biphenyl-4-sulfonic acid (hydroxyalkyl-phenyl)-amides and related compounds. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment and/or prevention, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of, inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activation in rheumatoid arthritis, osteoporosis, cancer associated bone disease, Paget's disease and the like. | 11-11-2010 |
20100292325 | P-MENTHAWE-3-CARBOXYLIC ACID ESTERS TO TREAT AIRWAYS DISEASES - The present invention relates to methods and devices for treating sensory discomfort in the upper airways of a human; treating sensory discomfort in the oropharynx of a human; alleviating pain from pharyngitis in a human; alleviating cough in a human; and ameliorating the symptoms and signs of asthma, dyspnea, sleep apnea, snoring or chronic obstructive pulmonary disease in a human. According to the invention, an active compound is delivered, preferably selectively delivered, to the oropharynx, preferably the oropharyngeal surfaces, more preferably the lower retropalatal oropharynx (LRO) of the patient. According to the invention, the active compound is a compound of the following formula, wherein R is C | 11-18-2010 |
20110003892 | ALL-TRANS RETINOID ESTERS AS ACTIVE PHARMACEUTICAL INGREDIENTS, ORAL AND TOPICAL DOSAGE FORM COMPOSITIONS THEREOF, AND METHODS OF TREATING SKIN CONDITIONS THEREOF - Active pharmaceutical ingredients being retinoic acid ester compounds including all- trans-retinoic acid tent-butyl ester, all-trans-retinoic acid iso-butyl ester, all-trans-retinoic acid iso-propyl ester, all-trans-retinoic acid sec-butyl ester, and, all-trans-retinoic acid 1-adamantyl ester, oral and topical dosage form compositions thereof, and methods of treating various skin conditions thereof. | 01-06-2011 |
20110015264 | INTRAMUSCULAR ANTIVIRAL TREATMENTS - The invention provides unit dosage forms, kits, and methods useful for treating viral infections. | 01-20-2011 |
20110077298 | Retinoid Derivative and Pharmaceutical Composition and Use Thereof - The invention relates to a retinoid derivative and pharmaceutical composition and use thereof. The compound of the invention is capable of preventing or treating hematological tumours, such as acute leukemia, chronic leukemia, multiple myeloma and lymphoma, solid tumours, such as liver cancer, rectal cancer, mammary cancer and esophagus cancer, and skin disorders, such as psoriasis and acne. | 03-31-2011 |
20110082203 | PROCESS TO DIAGNOSE OR TREAT BRAIN INJURY - A process for diagnosing and treating a neurological condition in a subject is provided that includes assaying a biological sample of a subject for the presence of one or more biomarkers; diagnosing a neurological condition based on a ratio of one or more of the biomarkers in the sample; and administering a therapeutic to the subject to alter the ratio of one or more biomarkers. The diagnosis numerous neurological conditions such as brain injury, or multiple organ injury is provided. | 04-07-2011 |
20110082204 | N-alkylcarbonyl-amino acid ester and N-alkylcarbonyl-amino lactone compounds and their use - The present invention generally relates to refreshing, soothing, and cooling compounds that affect sensory processes. More particularly, the present invention pertains to certain N-alkylcarbonyl-amino acid ester as described herein; compositions and articles comprising such compounds; and methods of treatment, for example, methods of increasing alertness, and decreasing fatigue or sleepiness, and alleviating ocular discomforts of irritation, itch, and pain. | 04-07-2011 |
20110124725 | Treatment for Meibomian Gland Dysfunction or Obstruction - A jojoba formulation has been developed for administration to the meibomian gland, for treatment of the symptoms of dry eye, and/or for drug delivery to the meibomian gland. The formulation incorporates the natural product jojoba wax, or components thereof, to enhance the spreading of the artificial tear as well as stabilize the tear film. The jojoba wax tear relieves irritation and discomfort as well as sharpens the blurred vision. Jojoba, because of its close chemical and physical properties to meibomian gland secretions, is effective upon topical application to penetrate the lid margin to reach the gland tissues where it may exert a therapeutic effect with or without an adjunctive agent. | 05-26-2011 |
20110152366 | N-alkylcarbonyl-amino acid ester compounds and their use for skin irritation, itch, and pain - The present invention generally relates to refreshing, soothing, and cooling compounds that affect sensory processes. More particularly, the present invention pertains to certain N-alkylcarbonyl- | 06-23-2011 |
20110160303 | N-ALKYLCARBONYL-AMINO ACID ESTER AND N-ALKYLCARBONYL-AMINO LACTONE COMPOUNDS AND THEIR USE - The present invention generally relates to refreshing, soothing, and cooling compounds that affect sensory processes. More particularly, the present invention pertains to certain N-alkylcarbonyl-amino acid ester and N-alkylcarbonyl-amino lactone compounds as described herein; compositions and articles comprising such compounds; and methods of treatment, for example, methods of alleviating the discomforts of irritation, itch, and pain in the skin and in the linings of the oral cavity and upper respiratory tract, for example, in methods of treatment of cough and/or asthma. | 06-30-2011 |
20110160304 | Inhibitors of Yeast Filamentous Growth and Method of Their Manufacture - The invention broadly relates to the use of α, β-unsaturated fatty acids to inhibit the filamentous growth of fungi and yeasts and to a method for producing same. In particular the invention relates to the use of optionally substituted C8 to C15 α, β-unsaturated fatty acids or salts, esters or amides thereof for inhibiting or retarding the yeast-to-mycelium transition of organisms having a dimorphic life cycle. | 06-30-2011 |
20110207815 | TETRAHYDRONAPHTHALENE COMPOUNDS - The invention relates to compounds of Formula (I) wherein R | 08-25-2011 |
20120029072 | PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES - Disclosed are pleuromutilin derivatives of formula (I) | 02-02-2012 |
20120129929 | COMPOUND USED TO PREVENT DISEASES CAUSED BY AQUAPORIN DEFICIENCY - A compound used to prevent diseases caused by aquaporin deficiency, which is 18β-Glycyrrhetinic acid derivative. Said compound can not only prevent diseases caused aquaporin deficiency, but be able to prevent aquaporin (AQP) production and enhance skin function. Since AQPs have many advantages in skin cells, e.g. promoting water and glycerine molecular transportation, increasing skin elasticity and cuticle moisture, increasing the cell proliferation and cell migration, aquaporin can promote skin bather function and wound cicatrization. Therefore, said compound can be applied potentially as a medicinal cosmetic in skin medicine cosmetology, or as a new medical composition to treat diseases caused by AQP abnormality, such as urine concentration defect, wound healing slow down, corneal re-epithelialization slow down and etc. | 05-24-2012 |
20120178806 | PHARMACEUTICAL FORMULATIONS COMPRISING 9-CIS-RETINYL ESTERS IN A LIPID VEHICLE - Pharmaceutical formulations comprising 9-cis-retinyl esters in a lipid vehicle are described as retinoid replacement therapies for treating retinal degenerations in humans. | 07-12-2012 |
20120184614 | N-alkylcarbonyl-amino acid ester compounds and their use for cough and pharyngitis - The present invention generally relates to refreshing, soothing, and cooling compounds that affect sensory processes. More particularly, the present invention pertains to certain N-alkylcarbonyl-amino acid esters compounds as described herein; compositions and articles comprising such compounds; and methods of treatment, for example, methods of reducing cough and pharyngeal irritation, itch, and/or pain. | 07-19-2012 |
20120220653 | PEST-CONTROL, COMPOSITIONS, AND METHODS AND PRODUCTS UTILIZING SAME - Pest-combating compositions containing modified volatility pest-control actives are formulated for sustained test-combating efficacy, utilizing oleochemicals subjected to transesterification, methanolysis or conversion of fatty acids to alkyl esters as modified volatility components. In a specific formulation, the pest-combating composition includes soy methyl ester and 2-undecanone. The composition may be constituted as a spray composition, lotion, paste, or other compositional form. Pests that may be usefully combated with such composition include mosquitoes, ticks, cockroaches, thrips, flies, gnats, beetles and aphids. | 08-30-2012 |
20130005804 | Novel Uses of Neuraminidase Inhibitors in Infectious Diseases - The present invention relates to methods of decreasing the infectivity, morbidity and rate of mortality, in treating diseases associated with a variety of pathogenic organisms, specifically diseases involving one or more pathogens that require neuraminidase as a virulence factor. In addition, the present invention uses biology based therapy to treat neuraminidase dependent infections or diseases dependent on sialic acid metabolism. | 01-03-2013 |
20130072555 | COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISEASES - In one aspect of the present invention, a pharmaceutical composition for treating a metabolic disease in a mammalian subject includes a therapeutically effective amount of (R)-all-trans-13,14-dihydroretinol and a pharmaceutically acceptable carrier or diluent. In another aspect of the present invention, pharmaceutical composition for treating a metabolic disease in a mammalian subject includes a therapeutically effective amount of (S)-all-trans-13,14-dihydroretinol and a pharmaceutically acceptable carrier or diluent. In a further aspect of the present invention, a method is provided for treating a metabolic disease in a mammalian subject. The method includes administering to the subject a pharmaceutical composition comprising at least one all-trans-13,14-dihydroretinoid, all-trans-13,14-dihydroretinoid derivative, or agent capable of modulating the level of at least one all-trans-13,14-dihydroretinoid or all-trans-13,14-dihydroretinoid derivative in the subject. | 03-21-2013 |
20130079403 | RETINAL DERIVATIVES AND METHODS FOR THE USE THEREOF FOR THE TREATMENT OF VISUAL DISORDERS - Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided. | 03-28-2013 |
20130137766 | Compound Used to Prevent Diseases Caused by Aquaporin Deficiency - A compound used to prevent diseases caused by aquaporin deficiency, which is 18β-Glycyrrhetinic acid derivative. Said compound can not only prevent diseases caused aquaporin deficiency, but be able to prevent aquaporin (AQP) production and enhance skin function. Since AQPs have many advantages in skin cells, e.g. promoting water and glycerine molecular transportation, increasing skin elasticity and cuticle moisture, increasing the cell proliferation and cell migration, aquaporin can promote skin bather function and wound cicatrization. Therefore, said compound can be applied potentially as a medicinal cosmetic in skin medicine cosmetology, or as a new medical composition to treat diseases caused by AQP abnormality, such as urine concentration defect, wound healing slow down, corneal re-epithelialization slow down and etc. | 05-30-2013 |
20130158113 | METHODS AND COMPOSITIONS FOR TREATING BRAIN CANCER - The present invention provides methods and compositions for treating brain cancer by cyclohexenone compounds. | 06-20-2013 |
20130253055 | POWDEROUS FORMULATIONS OF FAT-SOLUBLE ACTIVE INGREDIENTS - Stable powderous formulations containing a fat-soluble active ingredient, e.g., vitamin A, in a matrix of a native lupin protein composition are disclosed. | 09-26-2013 |
20130303609 | Fluorosubstituted-(3R,4R,5S)-5-guanidino 4-acetamido-3-(pentan-3-yloxy)cyclohex-1-enecarboxylic acid compound, ester and use thereof - The present invention relates to novel neuraminidase activity inhibitors and use thereof for prophylaxis and treatment of influenza infection, that is to fluorosubstituted4-acetamido-5-guanidino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylic acids and their esters of the general formula 1, pharmaceutically acceptable salts and/or hydrates thereof, | 11-14-2013 |
20130345304 | COMPOUNDS FOR SUPPRESSING A PERIPHERAL NERVE DISORDER INDUCED BY AN ANTI-CANCER AGENT - The present invention provides a medicament that suppresses (or mitigates) various neurological symptoms caused by a peripheral nerve disorder induced by an anti-cancer agent. | 12-26-2013 |
20140051756 | METHOD FOR PREVENTING OR TREATING ARRHYTHMIA, METHOD FOR PREVENTING OR TREATING ATRIAL FIBRILLATION, MODEL OF SUSTAINED ATRIAL FIBRILLATION, METHOD FOR PRODUCING THE MODEL, AND METHOD FOR SCREENING FOR ATRIAL FIBRILLATION INHIBITOR - A method for preventing or treating atrial fibrillation, including:
| 02-20-2014 |
20140148511 | Novel Uses of Neuraminidase Inhibitors in Infectious Diseases - The present invention relates to methods of decreasing the infectivity, morbidity and rate of mortality, in treating diseases associated with a variety of pathogenic organisms, specifically diseases involving one or more pathogens that require neuraminidase as a virulence factor. In addition, the present invention uses biology based therapy to treat neuraminidase dependent infections or diseases dependent on sialic acid metabolism. | 05-29-2014 |
20140309301 | ANTIVIRAL TREATMENTS - The invention provides unit dosage forms, kits, and methods and useful for treating viral infections. | 10-16-2014 |