Class / Patent application number | Description | Number of patent applications / Date published |
546094000 | Ring nitrogen is shared by two of the cyclos | 30 |
20080275241 | Polymorphic Forms of Dolasetron Base and Processes of Preparing Dolasetron Base, Its Polymorphic Forms and Salt Thereof - The present disclosure relates to a process for the preparation of endo-hexahydro-8-(3-indolylcarbonyloxy)-2,6-methano-2H-quinolizin-3(4H)-one or Dolasetron base. It also discloses a process for the preparation of endo-hexahydro-8-(3-indolylcarbonyloxy)-2,6-methano-2H-quinolizin-3(4H)-one mesylate or Dolasetron mesylate. Further, the present disclosure relates to a process for producing Form I of Dolasetron base, and to the novel crystalline polymorphs, Form II, III, IV and V of Dolasetron base and industrial processes for producing them. | 11-06-2008 |
20090030207 | Polymorphs of Dolasetron base and process for preparation thereof - The present invention provides polymorphic forms of dolasetron base and methods for their use and preparation. | 01-29-2009 |
20090281322 | THERAPEUTICALLY USEFUL SUBSTITUTED 1,7-DIPHENYL-1,2,3,5,6,7-HEXAHYDROPYRIDO[3,2,1-Ij]QUINOLINE COMPOUNDS - Disclosed herein are compounds represented by the structural formula: | 11-12-2009 |
20100081823 | Azo dyes - The azo dyes relate to thiophene azo dyes of the general formula: | 04-01-2010 |
20100311977 | METHOD FOR PRODUCING 2-AZAADAMANTANE - To provide a method whereby a 2-azaadamantane can easily be obtained in good yield. | 12-09-2010 |
20120172599 | SECOND-ORDER NONLINEAR OPTICAL COMPOUND AND NONLINEAR OPTICAL ELEMENT COMPRISING THE SAME - Problem to Be Solved: to provide a chromophore having a far superior nonlinear optical activity to conventional chromophores and to provide a nonlinear optical element comprising said chromophore. | 07-05-2012 |
20130281699 | Highly Pure Pyrroloquinolinyl-Pyrrole-2,5-Dione and Pyrroloquinolinyl-Pyrrolidine-2,5-Dione and Methods of Preparing Same - The present invention relates to highly-pure pyrroloquinolinyl-pyrrole-2,5-dione and pyrroloquinolinyl-pyrrolidine-2,5-dione, for example, 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin- | 10-24-2013 |
20140031551 | Purified Pyrroloquinolinyl-Pyrrolidine-2,5-Dione Compositions and Methods for Preparing and Using Same - The present invention relates to a form 1 and form 2 polymorph of (−)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione. The present invention also relates to (−)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione compounds having a chiral purity greater than 99%, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising these (−)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a composition comprising (−)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione having a chiral purity greater than 99% or a form 1 and form 2 polymorph of (−)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione. | 01-30-2014 |
20140187784 | RADIOACTIVE QUINOLINONE DERIVATIVE AND PHARMACEUTICAL DRUG COMPRISING THE SAME - It is intended to provide a radioactive compound that has higher selectivity for CYP11B2 than that for CYP11B1, exhibits highly selective accumulation in the adrenal gland compared with blood and organs adjacent to the adrenal gland, and permits commercial supply. The present invention provides a radioactive quinolinone derivative represented by the predetermined general formula or a salt thereof. | 07-03-2014 |
20160016860 | METHODS FOR PHOSPHINE OXIDE REDUCTION IN CATALYTIC WITTIG REACTIONS - A method for increasing the rate of phosphine oxide reduction, preferably during a Wittig reaction comprising use of an acid additive is provided. A room temperature catalytic Wittig reaction (CWR) the rate of reduction of the phosphine oxide is increased due to the addition of the acid additive is described. Furthermore, the extension of the CWR to semi-stabilized and non-stabilized ylides has been accomplished by utilization of a masked base and/or ylide-tuning. | 01-21-2016 |
20160024076 | PURIFIED PYRROLOQUINOLINYL-PYRROLIDINE-2,5-DIONE COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME - The present invention relates to a (±)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione dichloromethane. | 01-28-2016 |
20160137644 | METHOD FOR PRODUCING TRICYCLIC HETEROCYCLIC COMPOUND - It is an object of the present invention to provide a method for producing a high-purity tricyclic heterocyclic compound represented by formula (I), which is useful as a production intermediate for a pharmaceutical agent, wherein the method is an efficient production method with short steps and with a high yield, which does not use, as raw materials, expensive bromopyruvate and highly harmful copper chromite, and does not need silica gel column chromatography that generates, as by-products, large quantities of waste. The present invention relates to production of Compound (I) by the following method. | 05-19-2016 |
546095000 | Benzo(a)quinolizines (including hydrogenated) | 18 |
20080306267 | METHOD FOR MAKING TETRABENAZINE COMPOUNDS - A method of preparing a tetrabenazine compound (TBZ compound) having structure I comprising the steps of reacting a nucleophilic alkenyl species with aldehyde compound II and oxidizing the resultant allylic alcohol to provide enone III. The protecting group P | 12-11-2008 |
20090111990 | INTERMEDIATES FOR FLUORINATED DIHYDROTETRABENAZINE ETHER IMAGING AGENTS AND PROBES - The present invention provides novel fluorophilic compounds having structure VI | 04-30-2009 |
20090149654 | INTERMEDIATES FOR FLUORINATED TETRABENAZINE CARBINOL COMPOUNDS IMAGING AGENTS AND PROBES - The present invention provides novel fluorophilic compounds having structure VII | 06-11-2009 |
20100292478 | PROCESS OF PREPARING A RADIOACTIVE COMPOUND CONTAINING A FLUORINE-18 ISOTOPE - A process of preparing a radioactive compound containing a fluorine-18 isotope is provided. In one embodiment, the process may comprise forming a [ | 11-18-2010 |
20120010413 | Process for the Preparation of Pyrido [2,1-a] Isoquinoline Derivatives by Catalytic Asymmetric Hydrogenation of an Enamine - The invention relates to a process for the preparation of pyrido[2,1-a] isoquinoline derivatives of the formula | 01-12-2012 |
20120022260 | PROCESS FOR THE PREPARATION OF PYRIDO [2,1-a] ISOQUINOLINE DERIVATIVES COMPRISING OPTICAL RESOLUTION OF AN ENAMINE - This invention relates to a process for the preparation of pyrido[2,1-a] isoquinoline derivatives of the formula | 01-26-2012 |
20120035368 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES - The present invention relates to a novel process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula | 02-09-2012 |
20120232273 | PROCESS FOR THE PREPARATION OF A DPP-IV INHIBITOR - The present invention is concerned with an improved process for the preparation of pyrido[2,1-a]isoquinoline derivatives of formula I | 09-13-2012 |
20130018191 | PROCESS FOR THE PREPARATION OF PYRIDO [2,1-A] ISOQUINOLINE DERIVATIVES COMPRISING OPTICAL RESOLUTION OF AN ENAMINE - This invention relates to a process for the preparation of pyrido[2,1-a] isoquinoline derivatives of the formula | 01-17-2013 |
20130109859 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES BY CATALYTIC ASYMMETRIC HYDROGENATION OF AN ENAMINE | 05-02-2013 |
20130338366 | PROCESS FOR THE PREPARATION OF PYRIDO [2,1-A] ISOQUINOLINE DERIVATIVES COMPRISING OPTICAL RESOLUTION OF AN ENAMINE - This invention relates to a process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula | 12-19-2013 |
20140046066 | PROCESS FOR THE PREPARATION OF DPP-IV INHIBITOR - The present invention is concerned with an improved process for the preparation of pyrido[2,1-a]isoquinoline derivatives of formula I | 02-13-2014 |
20140187785 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES BY CATALYTIC ASYMMETRIC HYDROGENATION OF AN ENAMINE - The invention relates to a process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula | 07-03-2014 |
20140336386 | FORMULATIONS PHARMACOKINETICS OF DEUTERATED BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2 - The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders. | 11-13-2014 |
20140350257 | Process for the Preparation of a DPP-IV Inhibitor - The present invention is concerned with an improved process for the preparation of pyrido[2,1-a]isoquinoline derivatives of formula I | 11-27-2014 |
20150031888 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES BY CATALYTIC ASYMMETRIC HYDROGENATION OF AN ENAMINE - The invention relates to a process for the preparation of pyrido[2,1-a] isoquinoline derivatives of the formula | 01-29-2015 |
20150126743 | Process For The Preparation Of Pyrido [2,1-A] Isoquinoline Derivatives Comprising Optical Resolution Of An Enamine - This invention relates to a process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula | 05-07-2015 |
20150336951 | Process For The Preparation Of A DPP-IV Inhibitor - The present invention is concerned with an improved process for the preparation of pyrido[2,1-a]isoquinoline derivatives of formula I | 11-26-2015 |