Class / Patent application number | Description | Number of patent applications / Date published |
600477000 | With comparison means (e.g., ratio of or comparison to a standard) | 81 |
20080221457 | Multimodal Detection of Tissue Abnormalities Based on Raman and Background Fluorescence Spectroscopy - Methods and apparatus for classifying tissue use features of Raman spectra and background fluorescent spectra. The spectra may be acquired in the near-infrared wavelengths. Principal component analysis and linear discriminant analysis of reference spectra may be used to obtain a classification function that accepts features of the Raman and background fluorescence spectra for test tissue and yields an indication as to the likelihood that the test tissue is abnormal. The methods and apparatus may be applied to screening for skin cancers or other diseases. | 09-11-2008 |
20080228084 | Method and Apparatus for Reduction of Spurious Effects on Physiological Measurements - A method and apparatus for reducing motion artifact and spurious noise effects when computing estimates of values representative of at least one physiological parameter of a subject. For motion, measured motion values are compared with a motion threshold and the taking of physiological measurements used for computing the physiological parameter estimate values are either suspended until a measured motion value is under the threshold or a correction function is applied to the physiological measurements, the correction function being based on the measured motion values. As for spurious noise, physiological measurements taken while emitters are turned off are subtracted from physiological measurements taken while emitters are turned on in order to eliminate outside noise contamination. | 09-18-2008 |
20080269618 | Non-Invasive In-Situ Detection Of Malignant Skin Tissue And Other Abnormalities Using Laser Plasma Spectroscopy - Disclosed is a system and method for a non-invasive method for determining the presence or absence of cancerous cells in the skin and deeper tissue levels. The system includes a portable handheld laser coupled with a spectroscopy system to produce real-time material analysis of the presence of cancerous cells without sample preparation. The system focuses a high peak power laser pulse onto a targeted material to produce a laser spark or micro-plasma. Elemental line spectra emission is created, collected and analyzed by a spectrophotometer. The line spectra emission data is quickly displayed on a laptop computer. “Eye-safe” Class I lasers provide for practical in-situ laser plasma spectroscopy applications such as detection of cancerous skin tissues. The emission data can be used to detect changes in the levels of a series of elements that are associated with cancerous cells versus normal skin cells. The system also finds use during excisional biopsy procedures to ensure that all cancerous cells have been removed. | 10-30-2008 |
20080281208 | System, method and apparatus for the detection of patient-borne fluorescing materials - System, method and apparatus wherein a probe employing non-imagining optics is utilized in conjunction with a fluorescing (e.g., nanocrystal) tracer at the body of a patient. Excitation components within the probe working end are utilized to excite the nanocrystals to fluoresce at wavelengths in the near infrared region, such fluorescent energy is homogenized by interacting with involved tissue to provide a uniform fluorescing intensity over the surface of a photo-detector. Initialization and background determination procedures are described along with a technique for determining statistically significant levels of fluorescing activity. | 11-13-2008 |
20080306390 | OPTICAL SENSOR CONFIDENCE ALGORITHM - An implantable medical device system including an optical sensor monitors for the presence of overgrowth on the sensor by sensing light scattered by a measurement volume, the sensed light corresponding to a first wavelength, and deriving an overgrowth metric in response to the sensed light. The overgrowth metric is correlated to the presence of overgrowth on the sensor and is compared to a predetermined threshold. The presence of overgrowth on or near the sensor is detected in response to the overgrowth metric crossing the threshold. | 12-11-2008 |
20080319324 | DISTINGUISHING BETWEEN INVASIVE DUCTAL CARCINOMA AND INVASIVE LOBULAR CARCINOMA USING RAMAN MOLECULAR IMAGING - A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state. | 12-25-2008 |
20090005692 | Optical Imaging Method For Tissue Characterization - There is provided a method for detecting and characterizing abnormalities within biological tissues. The method involves the characterization of the optical properties of the tissue to derive relative values of physiological properties between normal and suspicious regions of the tissue. In some aspects of the invention optical imaging and other imaging modalities are combined to detect and identify a disease state of the tissue. | 01-01-2009 |
20090099458 | Diagnostic Methods for Osteoporosis - Methods of diagnosing bone disease such as osteoporosis are provided. The methods comprise detecting changes in the physical or chemical structure of a keratinized tissue as correlates of disease. The methods include detecting changes in the hardness, modulus, or level of sulfur bonding, particularly the level of disulfide bonding, in a keratinized tissue sample such as nail, hair, or skin. Changes in these variables serve as diagnostic markers of bone diseases that are associated with changes in bone elasticity and bone density. | 04-16-2009 |
20090112101 | METHOD, APPARATUS, AND ARTICLE TO FACILITATE EVALUATION OF OBJECTS USING ELECTROMAGNETIC ENERGY - Spectral information may be employed in process control and/or quality control of goods and articles. Spectral information may be employed in process control and/or quality control of media, for example financial instruments, identity documents, legal documents, medical documents, financial transaction cards, and/or other media, fluids for example lubricants, fuels, coolants, or other materials that flow, and in machinery, for example vehicles, motors, generators, compressors, presses, drills and/or supply systems. Spectral information may be employed in identifying biological tissue and/or facilitating diagnosis based on biological tissue. | 04-30-2009 |
20090143686 | OPTICAL COHERENT TOMOGRAPHY DIAGNOSTIC APPARATUS - An optical coherent tomography diagnostic apparatus including: a light source; a splitter for splitting the light outputted from the light source into a measuring light and a reference light; a measuring light path; a reference light path; a probe inserted into a body cavity and emitting the measuring light to a subject of measurement; an image forming unit for calculating intensity distribution of the reflection light and for forming a tomographic image; a standard light path for transmitting standard light obtained by further splitting the light; wherein the light path length when exerting interference between the standard light and the reference light is approximately equal to the light path length when exerting interference between the reference light and the reflection light, and there is included a calculation unit for calculating time change of coherent light data obtained by exerting interference between the standard light and the reference light. | 06-04-2009 |
20090253991 | METHOD AND SYSTEM FOR CHARACTERIZATION AND MAPPING OF TISSUE LESIONS - The present invention provides a method and an apparatus for the in vivo, non-invasive, early detection of alterations and mapping of the grade of these alterations, causing in the biochemical and/or in the functional characteristics of the epithelial tissues during the development of tissue atypias, dysplasias, neoplasias and cancers. The method is based, at least in part, on the simultaneous measurement of the spatial, temporal and spectral alterations in the characteristics of the light that is re-emitted from the tissue under examination, as a result of a combined tissue excitation with light and special chemical agents. The topical or systematic administration of these agents result in an evanescent contrast enhancement between normal and abnormal areas of tissue. The apparatus enables the capturing of temporally successive imaging in one or more spectral bands simultaneously. Based on the measured data, the characteristic curves that express the agent-tissue interaction kinetics, as well as numerical parameters derived from these data, are determined in any spatial point of the examined area. Mapping and characterization of the lesion, are based on these parameters. | 10-08-2009 |
20090306521 | NONINVASIVE MEASUREMENT OF CAROTENOIDS IN BIOLOGICAL TISSUE - A method and apparatus are provided for the determination of carotenoid antioxidants and similar chemical compounds in biological tissue such as living skin. The method and apparatus provide a noninvasive, rapid, accurate, and safe determination of carotenoid levels which in turn can provide diagnostic information of the antioxidant status of tissue. Reflection spectroscopy is used to measure the concentrations of carotenoids and similar substances in tissue. White light is directed upon the area of tissue that is of interest. A small fraction of diffusively scattered light is collected and measured. The tissue is pressured to temporarily squeeze blood out of the measured tissue volume while the reflection spectrum is continuously monitored, displayed, and analyzed in near real time. After an optimal time period of typically 15 seconds, the influence of the dominating hemoglobin and oxyhemoglobin tissue absorptions on the reflection spectra are minimized. | 12-10-2009 |
20100004545 | Method of Evaluating Metabolism of the Eye - A method and apparatus for measuring the retinal auto-fluorescence of a subject retina includes an excitation light source for providing an excitation light at a wavelength of at least 450 nm and an image capture device for recording an ocular auto-fluorescence signal generated in response to the excitation light. The image capture device includes a filter for reducing background non-signal wavelengths from the ocular auto-fluorescence signal and an image intensifier for increasing the ocular auto-fluorescence signal strength. The method and apparatus may further include a processor that analyzes the ocular auto-fluorescence signal to determine a contrast change or pattern to thereby detect retinal disease or damage. The processor may compare the images with control images, past images of the same eye or other diagnostic modalities such as fundus photography, angiography, or visual field testing to detect the retinal disease or damage. | 01-07-2010 |
20100049057 | IMAGING OF MACULAR PIGMENT DISTRIBUTIONS - Macular pigments are measured by spectrally selective lipofuscin detection. Light from a light source that emits light at a selected range of wavelengths that overlap the absorption band of macular carotenoids is directed onto macular tissue of an eye for which macular pigment levels are to be measured. Emitted light is then collected from the macular tissue. The collected light is filtered so that the collected light includes lipofuscin emission from the macular tissue at an excitation wavelength that lies outside the macular pigment absorption range and outside the excitation range of interfering fluorophores. The collected light is quantified at each of a plurality of locations in the macular tissue and the macular pigment levels in the macular tissue are determined from the differing lipofuscin emission intensities in the macula and peripheral retina. | 02-25-2010 |
20100049058 | FLUORESCENCE ENDOSCOPE AND FLUOROMETRY METHOD - Provided are a fluorescence endoscope and a fluorometry method that allow distinguishing between normal and affected areas in a simple manner by reducing the effect of the distance from a subject. Provided are a light source ( | 02-25-2010 |
20100094136 | ENDOSCOPE SYSTEM - A fluorescence distribution image of each fluorescent agent can be acquired from a fluorescence image that has been captured in a mixed state so as to improve the diagnosability of cancer cells. An endoscope system comprises: a light source section for selectively irradiating two or more types of excitation lights having different spectral characteristics so as to excite two or more types of fluorescent agents having different optical characteristics; an imaging section provided on a part to be inserted into a body cavity, and having a light-receiving sensitivity in the wavelength bands of the two or more types of fluorescence radiated from the observation target by respective types of excitation lights; a storage section for storing relation information between the fluorescence intensity and the concentration of each of the fluorescent agents; a concentration information computing section for computing concentration information of each of the fluorescent agents on the basis of the fluorescence intensities of two or more images captured by the imaging section and the relation information stored in the storage section, and outputting the concentration information; and a mode switching section capable of switching between a first fluorescence observation mode in which at least one of the fluorescence intensity images acquired by the imaging section is presented, and a second fluorescence observation mode in which the concentration information of each of the fluorescent agents computed by the concentration information computing section is presented. | 04-15-2010 |
20100094137 | METHODS AND SYSTEMS FOR OBSERVATION OF TYMPANIC FUNCTION - Methods and systems for endoscopic observation of tympanic function. | 04-15-2010 |
20100121201 | Non-invasive wound prevention, detection, and analysis - A computer-based method of analyzing a wound. An image of the wound is captured by a camera and a three-dimensional model of the wound is generated based on the image. A volume of the wound is calculated based on the three-dimensional model and changes to the calculated volume are monitored over a period of time. | 05-13-2010 |
20100130871 | SPECTRAL IMAGING DEVICE FOR HIRSCHSPRUNG'S DISEASE - The subject matter disclosed herein relates to the field of spectral imaging in the diagnosis and treatment of Hirschsprung's disease. Devices and methods are provided that enhance and accurately diagnose Hirschsprung's disease intraoperatively using spectral imaging technology. | 05-27-2010 |
20100179437 | IMAGE CAPTURING APPARATUS, IMAGE CAPTURING METHOD, AND COMPUTER READABLE MEDIUM - Provided is an image capturing apparatus for generating a multi-band image for examining a disease condition which has little amount of information. The image capturing apparatus includes: a variable spectroscopic element capable of varying a wavelength of light to be transmitted; a wavelength band table recording therein wavelength bands corresponded with disease conditions; an observation target identifying section that identifies a disease condition to be observed; a variable spectroscopic element control section that controls the variable spectroscopic element to sequentially transmit light rays of a plurality of wavelengths within a range of a wavelength band recorded in the wavelength band table in correspondence with the disease condition identified by the observation target identifying section; and an image capturing section that sequentially captures images by means of the light rays of a plurality of wavelengths transmitted through the variable spectroscopic element. | 07-15-2010 |
20100191126 | APPARATUS AND METHOD FOR WOUND DIAGNOSIS - A configurable scanner ( | 07-29-2010 |
20100198080 | Optical Methods to Intraoperatively Detect Positive Prostate and Kidney Cancer Margins - The present invention includes using optical spectroscopy as an innovative technique for ex-vivo demonstration of renal and prostate tumors. The apparatus and methods disclosed herein demonstrate the ability of optical spectroscopy to reliably differentiate tumor from normal tissue in renal specimens. | 08-05-2010 |
20100280393 | Optical Reflectance Spectroscopy for Evaluation of Radiation Injury - Non-invasive methods and systems are described for rapidly measuring in-vivo dose, severity, and progression of injury after exposure to damaging phenomena, such as ionizing radiation, chemical burns, or electrical burns. Optical reflectance backscattering spectroscopy is applied to identify and characterize the effects of such phenomena on an individual's whole body and in localized areas. | 11-04-2010 |
20110015528 | MEDICAL OBSERVATION SYSTEM AND PROCESSOR - A medical observation system, which includes a medical probe that observes a subject by scanning on the subject with laser light; a laser source that supplies the laser light to the medical probe; a judgment unit that judges whether the medical probe is in a predetermined state; and a control unit that controls an amount of laser light emitted from the laser source based on a judgment result by the judgment unit. | 01-20-2011 |
20110092824 | MONITORING A VITAL PARAMETER OF A PATIENT WITH "IN-SITU" MODULATION SCHEME TO AVOID INTERFERENCE - The invention relates to a method of monitoring a vital parameter of a patient by measuringattenuation of light emitted onto tissue of the patient, comprising the following steps: modulating the light with a modulation frequency or/and a modulation code; emitting the modulated light onto the tissue of the patient; collecting lightwhich is transmitted through the tissue or/and which is reflected from the tissue; demodulating the collected light; analyzing the demodulated collected light with regard to interference with ambient light; determining amodulation frequency or/and a modulation code for which interference with the ambient light is minimized or falls under a predefined threshold; and setting the modulation frequency or/and the modulation code for modulating the light according to the determined modulation frequency or/and a modulation code for which interference with the ambient light is minimized or falls under a predefined threshold. In this way a versatile and reliable possibility of monitoring a vital parameter of a patient with a high signal-to-interference ratio is provided. | 04-21-2011 |
20110178412 | CANCEROUS OR PRE-CANCEROUS TISSUE VISUALIZATION METHOD AND DEVICE - The cancerous or pre-cancerous tissue visualization method includes providing a fluorescence intensity image and a fluorescence lifetime image of the tissue;
| 07-21-2011 |
20110208065 | Optical Tomography System Using Short-Pulse Laser for Early Cancer Diagnostics - Time-resolved optical tomography systems using a short pulse laser, may be used in detection and treatment of cancer and tumors. Information is conveyed about tissue interior by the temporal variation of the observed scattered, and reflected measured when short-pulse lasers interact with scattering-absorbing media like tissue. Multiple scattering-induced temporal signature that persists for time periods greater than the duration of the source pulse and is a function of the source pulse width, the scattering and absorbing properties of the medium, and the location in the medium where the properties undergo changes. If the detection is carried out on the same short time scale (comparable to the order of the pulse width), the signal continues to be observed even for long durations after the pulse has been off due to the time taken for the photons to migrate to the detector after multiple scattering in the tissue media. | 08-25-2011 |
20110213253 | MULTIDIRECTIONAL SCAN AND ALGORITHMIC SKIN HEALTH ANALYSIS - Technologies generally applicable to detecting skin conditions are disclosed. A computer graphics scanning apparatus may be configured to capture skin image data, and use the captured skin image data to calculate a subsurface transfer function for the skin, which may identify subsurface properties of the skin. The identified subsurface properties may be correlated to one or more skin conditions for medical and/or cosmetic treatment diagnosis. | 09-01-2011 |
20110245687 | OPTICAL DETECTION METHOD AND DEVICE FOR OPTICAL DETECTION OF THE CONDITION OF JOINTS - The invention relates to a device and method for optical detection of the condition of a joint. The invention proposes: irradiating a subject's body part ( | 10-06-2011 |
20110251493 | METHOD AND SYSTEM FOR MEASUREMENT OF PHYSIOLOGICAL PARAMETERS - Method and system for measuring physiological parameters. The method includes capturing a sequence of images of a human face and identifying the location of the face in a frame of the video and establishing a region of interest including the face. Pixels are separated in the region of interest in a frame into at least two channel values forming raw traces over time. The raw traces are decomposed into at least two independent source signals. At least one of the source signals is processed to obtain a physiological parameter. | 10-13-2011 |
20110313297 | FLUOROSCOPY APPARATUS, FLUOROSCOPY SYSTEM AND FLUORESCENCE-IMAGE PROCESSING METHOD - Provided is a fluoroscopy apparatus ( | 12-22-2011 |
20120232407 | SMART PEDICLE TOOL - Various methods and devices are provided for navigating through bone. In one embodiment, a bone navigation device is provided and includes a bone penetrating member configured to be implanted in bone and having at least one optical waveguide extending therethrough. The optical waveguide is adapted to illuminate tissue surrounding the device and to receive reflected/transmitted light from the tissue to determine the optical characteristics of the tissue, thus facilitating navigation through the tissue. At least one window can be formed in the bone penetrating member for allowing light from the at least one optical waveguide to illuminate the tissue, and for receiving the reflected light. | 09-13-2012 |
20120259230 | TOOL FOR RECORDING PATIENT WOUND HISTORY - An apparatus for reliably recording, and reproducing, a history of a patient's wound using the cameras readily available on smart phone or blackberries by taking a digital record image of the wound along with a fiducial marker that has both shape and color fiducial elements. The image then contains sufficient information so that any display may be adjusted to accurately display the original color, and to accurately deduce the original size and shape of the wound. By transmitting the recorded images to a central database having image analysis capability, real time information may be made available indicating any significant changes that have occurred since the last recording of the same wound, providing an opportunity for the attending physician to give further attention to the patient without a time consuming second visit. | 10-11-2012 |
20120259231 | Excitation, Detection, and Projection System for Visualizing Target Cancer Tissue - A system visually distinguishes diseased tissue from healthy tissue after a treatment is administered to a patient to provide different concentrations of a fluorescent marking substance between the diseased tissue and the healthy tissue. A light source illuminates the tissue with excitation light. A detector detects light returning from the tissue, and a controller characterizes the returning light according to a measured property indicative of the different concentrations. A light projector projects light having a predetermined cue in response to the characterization of the returning light. | 10-11-2012 |
20120277595 | ADJUSTING PARAMETERS USED IN PULSE OXIMETRY ANALYSIS - Adjusting a pulse qualification criterion includes receiving a signal representing a plurality of pulses, where the signal is generated in response to detecting light scattered from blood perfused tissue. A characteristic is determined A pulse qualification criterion used for qualifying a pulse is adjusted in accordance with the characteristic. The pulses are evaluated according to the pulse qualification criterion. | 11-01-2012 |
20120323126 | SKIN AND WOUND ASSESSMENT TOOL - A diagnostic tool including a first arm and a second arm, a top surface of the first arm comprising a graphical ranking guide comprising a plurality of images that graphically illustrate at least a portion of rank classifier indicia for a classification system comprising a plurality of ranks, each of the images corresponding to at least one of the ranks. | 12-20-2012 |
20130030306 | MEASUREMENT DEVICE, MEASUREMENT METHOD, MEASUREMENT RESULT PROCESSING DEVICE, MEASUREMENT SYSTEM, MEASUREMENT RESULT PROCESSING METHOD, CONTROL PROGRAM, AND RECORDING MEDIUM - A measurement device (1) includes a probe (7) which irradiates a specific part or a specific location of a living body with excitation light and which receives fluorescence generated by irradiating the specific part or the specific location with excitation light. | 01-31-2013 |
20130123647 | Methods Useful in Optimizing the Treatment of Neuropathies and Targeting Tissues with Cosmetic Botulinum Injections - The present invention pertains to methods of determining where, on the skin, a diagnostic, therapeutic, or cosmetic agent is likely to be most effectively applied (e.g., injected), and to methods for monitoring a patient after such an agent has been administered. The monitoring can produce information useful in determining whether a diagnostic, therapeutic (e.g., surgical), or cosmetic regime should be initiated, continued, continued in a modified fashion, or terminated (e.g., for a brief or prolonged period of time). The methods can be repeated periodically and use a non-invasive, in vivo form of digital image speckle correlation (DISC) to track deformation of the skin. | 05-16-2013 |
20130218026 | AUTOMATED ASSESSMENT OF SKIN LESIONS USING IMAGE LIBRARY - An automated skin lesion assessment system may automatically assess a suspect skin lesion. An electronic image library may contain diagnosed skin lesion image data representative of images of a plurality of diagnosed skin lesions and, for each, a diagnosis of the skin lesion. An image capture system may capture an image of the suspect skin lesion. A computer processing system may compare the image of the suspect skin lesion with the diagnosed skin lesion image data and, based on this comparison, identify one or more diagnosed skin lesions which match the suspect skin lesion. A user interface may report the diagnoses of the diagnosed skin lesions that match the image of the suspect skin lesion. | 08-22-2013 |
20130253338 | REFLECTION DETECTION TYPE MEASUREMENT APPARATUS FOR SKIN AUTOFLUORESCENCE - The present invention provides a reflection detection type measurement apparatus for skin fluorescence, which is configured to perform light irradiation and light detection on a reference sample and a measurement target. | 09-26-2013 |
20130296712 | INTEGRATED NON-CONTACT DIMENSIONAL METROLOGY TOOL - An apparatus for determining endoscopic dimensional measurements, including a light source for projecting light patterns on a surgical sight including shapes with actual dimensional measurements and fiducials, and a means for analyzing the projecting light patterns on the surgical sight by comparing the actual dimensional measurements of the projected light patterns to the surgical site. The projected light patterns may include multiple wavelengths of light for measurements of different features of tissue and may be produced using a laser in conjunction with a light shaping optical diffuser, or using a light emitting diode in conjunction with a light shaping optical diffuser, or using a special filter. The projected light patterns may take the form of concentric rings with each ring representing a radius of a given dimension and may be a collimated pattern which does not significantly change size as a function of a distance to a projected plane. | 11-07-2013 |
20130331708 | DIAGNOSTIC IMAGING SYSTEM FOR SKIN AND AFFLICTION ASSESSMENT - A captured image is received depicting at least a portion of an assessment tool and an affliction to which the assessment tool is proximally located. An assessment image is generated from the captured image and configured to be presented on a display, the assessment image including at least a portion of the captured image including the portion of the assessment tool and the affliction to which the assessment tool is proximally located. The assessment tool includes at least a first arm depicting measurement indicators to which a size of the affliction is correlated. The captured image is processed to identify at least one dimension of the affliction. The dimension is compared to the measurement indicators depicted on the first arm of the assessment tool to determine the size of the affliction. | 12-12-2013 |
20140046196 | MESOSCOPIC TUMOR MICROENVIRONMENT IMAGING WITH IMPROVED CONTRAST - An apparatus and method of mesoscopic imaging which provide improved contrast to changes in tumor microenvironments are disclosed. The apparatus includes a light which illuminates tissue in vivo, a spectrometer which varies at least one parameter of the light, and optics which transmit light backscattered from the tissue. The optics comprise any one of (i) a small aperture 4-focal length (4-f) lens system within an angular cone of 2°-5°, (ii) a telecentric lens, and (iii) an anti-scatter grid and a camera lens. | 02-13-2014 |
20140046197 | CLASSIFICATION OF TUMOR TISSUE WITH A PERSONALIZED THRESHOLD - The present invention deals with discrimination of malignant tissue from normal and benign tissue in a single patient on the basis of optical spectroscopic measurements. Starting from spectroscopic measurements in normal tissue, reference values are obtained for the normal class. With spectroscopic measurements in other tissues data points can be assigned to new class(es) when the spectral characteristics fall outside a threshold defining the reference class. Thresholds between different classes can also be defined. Finding (the transition to) malignant tissue is based on comparing the spectroscopic values to the classification threshold discriminating normal and benign versus malignant tissue. Thus, the basis of normal spectroscopic measurements is tuned to the individual patient characteristic. Discriminating the normal plus benign and malignant from that reference is more efficient compared to the reference of the all patient database. | 02-13-2014 |
20140052005 | ENDOSCOPE APPARATUS AND MEASURING METHOD - An endoscope apparatus and a measuring method measure a subject using a pattern projection image obtained by projecting a fringe pattern onto a subject. The endoscope apparatus includes an elongated insertion section, an imaging section at a tip portion of the insertion section to acquire the image of a subject, an illumination section at the tip portion of the insertion section to emit the illumination light that illuminates an observation visual field of the imaging section, and a pattern projection section at the tip portion of the insertion section to project a fringe pattern onto the subject. A tip surface of the insertion section includes an objective optical system that forms the image of the subject on the imaging section, one or more illumination windows through which illumination light is emitted, and one projection window through which a fringe pattern is projected onto the subject from the pattern projection section. | 02-20-2014 |
20140058271 | SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN - A system for analyzing a body lumen including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end; at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located along a distal portion of the conduit; a spectrometer connected to the at least one delivery waveguide and the at least one collection waveguide, the spectrometer configured to perform diffuse reflectance spectroscopy, wherein the spectrometer emits at least one primary radiation signal of a wavelength having an absorption coefficient of between about 8 cm | 02-27-2014 |
20140081149 | OPTICAL MEASUREMENT APPARATUS - An optical measurement apparatus according to the present invention includes a probe having an irradiation fiber that propagates light supplied from a base end and irradiates the light from a leading end and a plurality of light receiving fibers that propagate light incident from leading ends and output the light from base ends; a light source unit that generates white light to be irradiated onto the body tissue and supplies the white light to the irradiation fiber; a measurement unit that performs spectrometry for returned light from the body tissue output from each of the light receiving fibers at a predetermined measurement timing; and a determination unit that determines whether or not a measurement value measured by the measurement unit is equal to or smaller than a predetermined threshold value, and causes the light source unit to perform a light emission process for obtaining a characteristic value of the body tissue for a predetermined time and causes the measurement unit to perform a spectrometry process for obtaining a characteristic value of the body tissue for the predetermined time if it is determined that the measurement value measured by the measurement unit is equal to or smaller than the predetermined threshold value. | 03-20-2014 |
20140121533 | DOUBLE MEMBRANE PROSTATE GLOVE - Systems and methods are provided herein that generally involve measuring a prostate or other object. In some embodiments, a membrane can be sealed over a digit extension to form a closed volume. The closed volume can be inflated via an inflation tube, and a reference pattern can be disposed within the closed volume along with a measurement assembly. In use, a user can put on the glove, position the membrane in proximity to a rectal wall overlying a prostate, and inflate the membrane. As the user slides their finger across the rectal wall, optical fibers in the measurement assembly can move relative to a reference pattern, and a controller can sense light reflected through the fibers from the reference pattern. The controller can calculate or estimate various attributes of the prostate based on the reflected light, such as the palpable surface width or volume. | 05-01-2014 |
20140121534 | GRID FOR MEASURING PROSTATE VOLUME - Systems and methods are provided herein that generally involve measuring a prostate or other object. In some embodiments, a membrane can be sealed over a digit extension to form a closed volume. The closed volume can be inflated via an inflation tube, and a reference pattern can be disposed within the closed volume along with a measurement assembly. In use, a user can put on the glove, position the membrane in proximity to a rectal wall overlying a prostate, and inflate the membrane. As the user slides their finger across the rectal wall, optical fibers in the measurement assembly can move relative to a reference pattern, and a controller can sense light reflected through the fibers from the reference pattern. The controller can calculate or estimate various attributes of the prostate based on the reflected light, such as the palpable surface width or volume. | 05-01-2014 |
20140200459 | APPARATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE - The present invention relates to an apparatus | 07-17-2014 |
20140213910 | METHOD AND APPARATUS FOR PERFORMING QUALITATIVE AND QUANTITATIVE ANALYSIS OF BURN EXTENT AND SEVERITY USING SPATIALLY STRUCTURED ILLUMINATION - Frequent monitoring of early-stage burns is necessary for deciding optimal treatment and management. Superficial-partial thickness and deep-partial thickness burns, while visually similar, differ dramatically in terms of clinical treatment and are known to progress in severity over time. The disclosed method uses spatial frequency domain imaging (SFDI) far noninvasively mapping quantitative changes in chromophore and optical properties that may be an indicative of burn wound severity. A controlled protocol of graded burn severity is developed and applied to 17 rats. SFDI data is acquired at multiple near-infrared wavelengths over a course of 3 h. Burn severity is verified using hematoxylin and eosin histology. Changes in water concentration (edema), deoxygenated hemoglobin concentration, and optical scattering (tissue denaturation) are statistically significant measures, which are used to differentiate superficial partial-thickness burns from deep-partial thickness burns. | 07-31-2014 |
20140221846 | SYSTEM AND METHOD FOR DETERMINING TISSUE CHARACTERISTICS - An apparatus to interrogate, receive, and analyze full emission spectra for at least one fluorescence excitation wavelength and for at least one reflectance measurement to determine tissue characteristics. The apparatus includes a base unit having illumination, detection and control sub-units, the illumination sub-unit providing illumination optical energy for illuminating a target tissue and the detection sub-unit detecting tissue characteristics of a target tissue, a separate tissue interface unit, and a pathway coupling the base unit and the tissue interface unit. The system and apparatus may also include a tube for maintaining the distance between the tissue and units and for surrounding the tissue to prevent patient movement from being transmitted to the tissue. | 08-07-2014 |
20140249427 | DEPTH-SELECTIVE FIBER-OPTIC PROBE - Systems and methods that facilitate analysis of superficial tissue based at least in part on a depth-selective fiber optic probe are discussed herein. The depth-selective fiber optic probe can include an illumination fiber for providing light to the superficial tissue, a collection fiber for collected reflected light, a ball lens that couples the fibers, and a protective overtube that houses the ball lens and fibers. The distances between the ball lens and fibers and between the fibers can be optimized based on several factors, such as by minimizing the illumination spot size, maximizing the overlap between the illumination and collection spots, and based on the angle between the illumination and collection beams. | 09-04-2014 |
20140303505 | MEASURING APPARATUS, MEASURING METHOD, AND PARAMETER SETTING METHOD - There is provided a measuring apparatus, including a light receiving element, provided at a position facing a measurement object region on which is placed a measurement object, which forms an image with light from the measurement object region, light emitting elements, arranged surrounding the light receiving element, which emit light for measuring the measurement object, and reflective optical elements, provided above the light emitting elements, which guide, to the measurement object region, emission light radiated from the light emitting elements. A light receiving surface of the light receiving element and light emission surfaces of the light emitting elements are positioned mutually on a same plane. The emission light radiated from the light emitting elements is reflected by the reflective optical elements, and center lines of the emission light radiated from each of the light emitting elements pass through an approximate center of the measurement object region. | 10-09-2014 |
20140350411 | METHOD AND SYSTEM FOR DETECTING AND ALLEVIATING NECK DISCOMFORT OF A MOTOR VEHICLE OCCUPANT - A camera mounted in a motor vehicle cabin monitors an upper body and/or face of a vehicle occupant. A computer unit applies pattern recognition methods to compare an image from the camera with reference data stored in a database, and to determine based on the comparison that the occupant is experiencing neck discomfort. The neck discomfort determination is made based on the comparison indicating a change in occupant posture, a change in occupant facial expression, and/or a relaxation movement of the upper body and/or of a head of the occupant. If neck discomfort is detected, warm air and/or infrared light is directed toward the affected neck area to alleviate the discomfort. | 11-27-2014 |
20150032010 | OPTICAL MEASUREMENT DEVICE - An optical measurement device includes: a measurement light source unit that emits measurement light; measurement probe including an illumination fiber configured to radiate the measurement light to a living tissue, and a light-receiving fiber configured to receive return light of the measurement light reflected and/or scattered from the living tissue; a detection unit that detects the return light; an illumination control unit that causes the measurement light source unit to execute alternately emission and stoppage of the measurement light during the measurement and to emit the measurement light such that the emission time is longer than the stoppage time; and a computation unit that removes, from an intensity of return light of the measurement light detected by the detection unit, a detected intensity of return light of the observation light radiated by an endoscope and reflected from the living tissue. | 01-29-2015 |
20150038852 | OPTICAL METHODS FOR MONITORING OFBIREFRINGENT TISSUES - The present invention comprises methods and systems/devices for non-invasively measuring birefringent tissues (e.g. collagen) and changes during treatment of tissue, e.g., denaturation by the application of RF energy, through linear dichroism, circular dichroism, or birefringence. The invention optionally uses polarization sensitive optical measurements to discriminate between denaturation of unidirectionally oriented strands of collagen, such as a ligament or tendon, and denaturation of planar collagen surfaces, such as the dermal layer of the skin or collagen in joint capsules. | 02-05-2015 |
20150045677 | SYSTEMS AND METHODS FOR ENDOSCOPIC ANGLE-RESOLVED LOW COHERENCE INTERFEROMETRY - A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam towards the selected area at an angle, and receiving an angle-resolved scattered sample beam. The angle-resolved scattered sample beam is cross-correlated with the reference beam to produce an angle-resolved cross-correlated signal about the selected area, which is spectrally dispersed to yield an angle-resolved, spectrally-resolved cross-correlation profile having depth-resolved information about the selected area. The angle-resolved, spectrally-resolved cross-correlation profile is processed to obtain depth-resolved information about scatterers in the selected area. | 02-12-2015 |
20150051498 | METHODS AND APPARATUS FOR COAXIAL IMAGING OF MULTIPLE WAVELENGTHS - A hyperspectral/multispectral imager comprising a housing is provided. At least one light source is attached to the housing. An objective lens, in an optical communication path comprising originating and terminating ends, is further attached to the housing and causes light to (i) be backscattered by the tissue of a subject at the originating end and then (ii) pass through the objective lens to a beam steering element at the terminating end of the communication path inside the housing. The beam steering element has a plurality of operating modes each of which causes the element to be in optical communication with a different optical detector in a plurality of optical detectors offset from the optical communication path. Each respective detector filter in a plurality of detector filters covers a corresponding optical detector in the plurality of optical detectors thereby filtering light received by the corresponding detector from the beam steering element. | 02-19-2015 |
20150057551 | Self-Diagnostic Method for Jaundice and an APP Product Thereby - A self-diagnostic method for momentarily generating a jaundice index, clinically equivalent to the serum bilirubin level, for newborns including Step S | 02-26-2015 |
20150057552 | METHODOLOGY FOR DETERMINING CONCENTRATION OF THE TYPES OF MELANIN PIGMENT IN THE SKIN - The present invention relates generally to a methodology of determining the concentration of the types of melanin, either eumelanin or pheomelanin, in the skin wherein the process for such determination is non-invasive and based on digital signal and image analysis of hyperspectral sensing and multi-spectral data. | 02-26-2015 |
20150065888 | METHOD AND APPARATUS FOR OBTAINING VASODILATION DATA REPRESENTING CUTANEOUS LOCAL THERMAL HYPEREMIA RESPONSE OF A SUBJECT - Disclosed herein is a method for obtaining a value of at least one vasodilation parameter representing the cutaneous local thermal hyperemia response of a subject. The temperature of a sampling site is raised from a first temperature to a second temperature and maintained for an initial heating period, and an initial maximum red blood cell flux (RBCF) of the sampling site and a mean arterial pressure of the subject is obtained. An initial maximum cutaneous vascular conductance (CVC | 03-05-2015 |
20150080742 | OPTICAL COHERENT IMAGING MEDICAL DEVICE - An OCI medical device includes a coherent light source, a light sensor, a first processing unit adapted to calculate OCI Data from the light sensor, a control unit which allows taking or loading of at least one Reference OCI Value, a second processing unit adapted to calculate the Intra-Individual Relative Assessment of the OCI Data of an Imaging Zone and the at least one OCI Reference Value, and display means adapted to show at least one Relative OCI Value. Uses and a method for assessing the blood flow of a body region use OCI imaging and include an Intra-Individual Relative Assessment between OCI Data of the Imaging Zone and at least one Reference OCI Value. | 03-19-2015 |
20150133794 | CANCER CELL DETECTION USING DIELECTROPHORETIC DYNAMIC LIGHT SCATTERING (DDLS) SPECTROSCOPY - Non-invasive apparatus and method for determining and monitoring glucose concentrations in human subjects. Glucose level is estimated through the effect of glucose on biological cells with glucose dependencies, e.g., red blood cells. The invention is based on the interaction of such cells with oscillating electric field gradients. The response of biological cells depends on factors including shape, size, and electrical charge distribution. The field gradient causes the cells to undergo characteristic motion which is detected by light beam scattering. The autocorrelation of the scattered light is computed, and the Fourier transform (FT) is performed to produce a characteristic velocity spectrum in which the peaks are characteristic of the cell “bio-electrical” states. The glucose level is estimated through measurements of changes of FT with changes in glucose levels after calibration with standard glucose methods. | 05-14-2015 |
20150148687 | METHOD AND APPARATUS FOR MEASURING HEART RATE - Provided is a method of measuring a heart rate in an electronic device. The method includes obtaining a face image of a subject by using the electronic device; determining a target region within the obtained face image; analyzing color information within the determined target region; and determining a heart rate of the subject on the basis of the analyzed color information. The analyzing of color information is performed on the basis of a differential arithmetic operation between a first color component and a second color component within the target region. | 05-28-2015 |
20150305635 | PORTABLE ELECTRONIC DEVICE AND HEART RATE SENSING METHOD OF THE SAME - A portable electronic device uses the initial heartbeat value to calculate a possible heartbeat variation. Then a reference range is determined. Only the real time heartbeat value falling in the reference range is output as a correct real time heartbeat value. Thus, the too large or too small erroneous heartbeat values influenced by the vibration noise are eliminated to precisely output the correct real time heartbeat value. Therefore, the extra vibration sensors need not to be installed to lower the cost and to reduce the volume. | 10-29-2015 |
20150351635 | Portable Broadband Diffuse Optical Spectroscopic Imaging (DOSI) Device for Noninvasive Tissue Characterization - A diffuse optical spectroscopic imaging (DOSI) apparatus for tissue spectroscopy measures absorption and scattering properties of tissue using multi-frequency frequency domain photon migration in a modular or networkable platform to provide full broadband information content. The apparatus includes: a broadband signal generator; a driver having an input coupled to the signal generator; a light source coupled to the driver, the light source for exposing the tissue to broadband modulated light at a plurality of wavelengths; an optical detector for receiving returned light from the tissue; an amplitude detection circuit communicated to the optical detector; a phase detection circuit communicated to the optical detector; and a plurality of filters and amplifiers, wherein the optical detector, amplitude detection circuit and phase detection circuit are interconnected with each other by corresponding ones of the plurality of filters and amplifiers to isolate signals and increase signal-to-noise ratio. | 12-10-2015 |
20150359459 | SYSTEMS, DEVICES, AND METHODS FOR ESTIMATING BILIRUBIN LEVELS - Systems, methods, and devices are provided for estimating bilirubin levels. In one aspect, a method for estimating the level of bilirubin in a patient includes receiving image data for at least one image including a region of the patient's skin and a color calibration target. Color-balanced image data for the skin region is generated based on a subset of the image data corresponding to the color calibration target and the skin region. The bilirubin level in the patient is estimated based on the color-balanced image data for the skin region. | 12-17-2015 |
20150366454 | METHOD AND APPARATUS FOR OPTICAL MEASUREMENTS UNDER AMBIENT LIGHT CONDITIONS - Examples of a spectroscopy system with a specially design ambient illumination system are disclosed. The ambient illumination system comprises one or more light emitting diodes (LEDs) that provide illumination light in the wavelength of 400-785 nm. The ambient illumination system can further comprise a filter to block light above 785 nm. The filter can be placed directly in front of LED emitters. The LEDs can be white LEDs or RGB LEDs. The spectroscopy system can further comprise a control system that can receive a signal from the spectral probe when the spectral measurements commence and can instantaneously send a signal to automatically switch off the ambient illumination system and to receive a signal from the spectral probe when the spectral measurements are terminated and automatically switch on the ambient illumination system. Examples of methods of operating the spectroscopy system and the ambient illumination system are disclosed. | 12-24-2015 |
20150374263 | MEDICAL IMAGE PROCESSING DEVICE, METHOD FOR OPERATING THE SAME, AND ENDOSCOPE SYSTEM - First RGB image signals are inputted. Color difference signals Cr and Cb are calculated from the first RGB image signals. In a feature space formed by the color difference signals Cr and Cb, a first process and a second process are performed. In the first process, coordinates which correspond to the first, second, and third observation areas are moved in a parallel manner such that the coordinates which correspond to the second observation area are moved to a reference area that contains the origin point. In the second process, the coordinates which correspond to the first observation area and the coordinates which correspond to the third observation area are moved away from each other. | 12-31-2015 |
20160058288 | THREE DIMENSIONAL TISSUE IMAGING SYSTEM AND METHOD - Multispectral digitized images are provided by utilizing 2 or more spectral bands, providing images and information regarding a pigmented or other differentiated tissue sample at differing depths. The images are transformed to enhance morphological patterns characteristic of melanoma, such as the statistical properties of the pigment network, image texture or homogeneity, and the lesion reflectance, in order to provide information about lesion morphology at different depths. The images can also be processed and transformed to extract features such as blood volume saturation, oxygen saturation, or other characteristics that can be identified based on differential reflectance or absorption of light. | 03-03-2016 |
20160066979 | PHOTONIC PROBE APPARATUS WITH INTEGRATED TISSUE MARKING FACILITY - The invention relates to a photonic probe apparatus and a method for probing tissue to detect and mark biological tissue with cancerous or precancerous states. The apparatus involves a probe for illuminating tissue and collecting light from an illuminated tissue region through the probe, a unit for analyzing collected light to determine whether a threshold measure of probability of a cancerous or precancerous lesion in the probed tissue region in contact with the probe is exceeded, and an integrated tissue marking facility which can be activated to mark the probed tissue region through the probe when the threshold measure is exceeded. The photonic probe apparatus and the method are especially suitable for probing regions in squamous and columnar epithelia to detect and mark regions with cervical cancer or cervical intraepithelial neoplasia (CIN). | 03-10-2016 |
20160128611 | METHODS AND SYSTEMS FOR OBSERVATION OF TYMPANIC FUNCTION - Methods and systems for endoscopic observation of tympanic function. | 05-12-2016 |
20160157723 | STRUCTURED-LIGHT IMAGING SYSTEMS AND METHODS FOR DETERMINING SUB-DIFFUSE SCATTERING PARAMETERS - A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material. | 06-09-2016 |
20160157736 | System and Methods for Assessment of Relative Fluid Flow Using Laser Speckle Imaging - A system and method provide the capability to assess relative fluid flow. A light source is configured to generate a coherent light beam and direct the coherent light beam at an object. A detector is configured to receive light remitted from the object and output image data, and a controller is configured to receive the image data and calculate a relative fluid flow value based on a speckle contrast image of the image data. | 06-09-2016 |
20160174848 | SYSTEM, METHOD, AND APPARATUS FOR PERFORMING HISTOPATHOLOGY | 06-23-2016 |
20160198994 | METHOD OF CHARACTERIZING WOUNDS WITH RAMAN SPECTROSCOPY | 07-14-2016 |
20160249809 | PORTABLE NONINVASIVE INSPECTION DEVICE | 09-01-2016 |
20160249810 | COMPACT LIGHT SENSORS WITH SYMMETRICAL LIGHTING | 09-01-2016 |
20160249861 | ANALYSIS PROCESS DEVICE | 09-01-2016 |
20220133214 | LESION AREA DIVIDING DEVICE, MEDICAL IMAGE DIAGNOSTIC SYSTEM, LESION AREA DIVIDING METHOD, AND NON-TRANSITORY COMPUTER-READABLE MEDIUM STORING PROGRAM - A rectangle creating unit creates a rectangle circumscribing a lesion area in a medical image. A division-number-ratio calculating unit calculates a division-number ratio based on an image aspect ratio of an input image to be input to a device that identifies a lesion and on a rectangle aspect ratio between the length in the vertical direction of and the length in the horizontal direction of the rectangle. A multiplying-factor calculating unit calculates, based on the division-number ratio, a resizing multiplying-factor for each of the vertical direction and the horizontal direction of a rectangular image encircled by the rectangle and including the lesion area. A resizing unit resizes the rectangular image with the resizing multiplying-factor. A dividing unit divides the resized rectangular image into one or more images in such a manner that the size of each divided image matches the size of the input image. | 05-05-2022 |