Entries |
Document | Title | Date |
20110008223 | FLUID INTERFACE CARTRIDGE FOR A MICROFLUIDIC CHIP - An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip. | 01-13-2011 |
20110038766 | MICROCHANNEL AND ANALYZING DEVICE - A microchannel | 02-17-2011 |
20110044863 | MICRO FLUID DEVICE - The present invention provides a microfluidic device with a micro-pump system in which the production process is simplified and the device is further downsized. A microfluidic device | 02-24-2011 |
20110044864 | SUPPORTING UNIT FOR MICROFLUID SYSTEM - The present invention provides a supporting unit of microfluid system having a smaller restriction on the number of the steps and capacity of the reaction and analysis that can be produced easily, and a microfluid-system supporting unit allowing mounting of complicated fluid circuits densely. The present invention relates to a microfluid-system supporting unit, comprising a first supporting plate and at least one hollow filament constituting the channel of the microfluid system, wherein the hollow filament is placed on the first supporting plate in any shape and a particular internal region of the hollow filament has a function. | 02-24-2011 |
20110064628 | MICROFLUIDIC CHIP FEATURES FOR OPTICAL AND THERMAL ISOLATION - A microfluidic chip includes microfluidic channels, elements for thermally and optically isolating the microfluidic channels, and elements for enhancing the detection of optical signal emitted from the microfluidic channels. The thermal and optical isolation elements may comprise barrier channels interposed between adjacently-arranged pairs of microfluidic channels for preventing thermal and optical cross-talk between the adjacent microfluidic channels. The isolation element may alternatively comprise reflective film embedded in the microfluidic chip between the adjacent microfluidic channels. The signal enhancement elements comprise structures disposed adjacent to the microfluidic channels that reflect light passing through or emitted from the microfluidic channel in a direction toward a detector. The structures may comprise channels or a faceted surface that redirects the light by total internal reflection or reflective film material embedded in the microfluidic chip. | 03-17-2011 |
20110076204 | PINCH VALVE AND METHOD FOR MANUFACTURING SAME - A pinch valve, a chip including a pinch valve of this type, a peristaltic pump including a pinch valve of this type and a method for manufacturing same. The pinch valve includes a first substrate, a second substrate, and a third substrate, the third substrate being farmed from an elastic material and situated between the first and second substrates, the first substrate adjoining the third substrate and having at least one first recess on the side adjacent to the third substrate, the second substrate adjoining the third substrate and having at least one second recess on the side adjacent to the third substrate, the first recess and the second recess being situated at least partially opposite each other. | 03-31-2011 |
20110085949 | Microfluidic device, composition and method of forming - A composition made of at least 60 wt. % of a thermoplastic elastomer resin and additives that are solid at least from 0-50° C., that has a Shore A hardness that is less than about 50 bears a patterned surface, the pattern comprising at least one microfluidic channel having a cross-sectional dimension smaller than 100 microns is a substrate for forming a microfluidic device. The chief advantages of such compositions are: its ability to bond in a sealing manner to smooth surfaces of many different compositions, its ease of manufacture and microstructure patterning, and its general impermeability to liquids. | 04-14-2011 |
20110104024 | MICROVALVE AND SEALING DEVICE FOR USE IN A MICROFLUIDICS SYSTEM, AND METHOD FOR THE PRODUCTION THEREOF - A microvalve for controlling fluid flows, and a sealing device for sealing cavities in a microfluidic system, particularly in a lab-on-a-chip system, and a method for the production thereof. A sealing surface of a valve body, or a sealing element, respectively, rests on a sealing surface of a substrate and is pressed against the sealing surface of the substrate in a fluid-tight manner by means of a clamping element. The clamping element and/or the valve body, or the sealing element, respectively, are at least partially elastic. | 05-05-2011 |
20110104025 | METHOD FOR PRODUCING RECONFIGURABLE MICROCHANNELS - A microfluidic device, including a microfluidic network, including: a) two parallel plates each including one or more electrodes, b) at least one channel, arranged between the two plates, made from a material obtained by solidification or hardening of a material of a first fluid, and c) a mechanism varying a physical parameter of the material constituting walls of the channel so as to cause the material to pass at least from the liquid state to the solid state. | 05-05-2011 |
20110123413 | SURFACES, INCLUDING MICROFLUIDIC CHANNELS, WITH CONTROLLED WETTING PROPERTIES - The present invention generally relates to coating materials, including photoactive coating materials. In some aspects of the invention, a sol-gel is provided that can be formed as a coating on a microfluidic channel. One or more portions of the sol-gel can be reacted to alter its hydrophobicity, in some cases. For instance, in one set of embodiments, a portion of the sol-gel may be exposed to light, such as ultraviolet light, which can be used to induce a chemical reaction in the sol-gel that alters its hydrophobicity. In one set of embodiments, the sol-gel can include a photoinitiator, that upon exposure to light, produces radicals. Optionally, the photoinitiator may be conjugated to a silane or other material within the sol-gel. The radicals so produced may be used to cause a polymerization reaction to occur on the surface of the sol-gel, thus altering the hydrophobicity of the surface. In some cases, various portions may be reacted or left unreacted, e.g., by controlling exposure to light (for instance, using a mask). Such treated surfaces within a microfluidic channel may be useful in a wide variety of applications, for instance, in the creation of emulsions such as multiple emulsions. | 05-26-2011 |
20110135546 | MICROFLUIDIC FOIL STRUCTURE FOR METERING OF FLUIDS - The invention relates to a microfluidic device for metering liquids into a microfluidic network. The microfluidic channels or chambers are at least partly formed by the introduction of suitable structures into a film above the substrate carrier, so that at least some of the flow of fluid through the network takes place above the plane of the substrate. In order to form a stable channel structure or chamber structure in the film, it is envisaged that in the edge zone between the unattached and attached portions a wedge of material is formed by the viscous flow of the film material as the film is bonded to the substrate, this wedge forming a transition between the chamber wall and the substrate and raising the chamber wall above the plane of the substrate. In one method of producing a finished microfluidic structure a flat planar film is laminated onto a flat sheet-like substrate. During the lamination a mask having at least one recess or opening is pressed onto the film and onto the substrate under pressure and/or under the effect of heat. The film is thereby brought to a temperature at which there is a viscous flow of film and/or substrate medium into the region of the recess or opening, so that a wedge of material is formed and the film bulges up in the region of the recess to form a chamber. The invention further relates to methods of metering at least one liquid in a microfluidic network, in which a capillary stop is overcome by actuating the film, the film being wetted as the capillary stop is removed. | 06-09-2011 |
20110142734 | DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT - The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid. | 06-16-2011 |
20110165037 | INTERFACES THAT ELIMINATE NON-SPECIFIC ADSORPTION, AND INTRODUCE SPECIFIC INTERACTIONS - A microfluidic system comprising a microchannel, a carrier fluid comprising a fluorinated oil in the microchannel, at least one plug comprising an aqueous plug-fluid in the microchannel and substantially surrounded on all sides by the carrier-fluid, and a fluorinated surfactant comprising a functional group capable of selectively binding a target molecule is disclosed. A compound for use therewith and a method of synthesizing a fluorinated surfactant are also provided. | 07-07-2011 |
20110171086 | MICROFLUIDIC DEVICE - A microfluidic device is provided, the microfluidic device comprising: a plurality of chambers ( | 07-14-2011 |
20110194994 | Chemical synthesis and analysis via intergrated or sequential photochemical and electrochemical processes for use in microfluidic, lab-on-a-chip, and green-chemistry applications - A microfluidic system comprising a plurality of photochemical reaction stages, the microfluidic system comprising a computational processor, a plurality of electrically-controllable photochemical reaction stages, and a series of controllable interconnections for connecting the photochemical reaction stages. In an implementation, the computational processor controls the plurality of electrically-controllable photochemical reaction stages and the controllable interconnections so as to implement a multi-step photochemical synthesis function. | 08-11-2011 |
20110286895 | MICROVALVE DEVICE AND METHOD OF MANUFACTURING THE SAME - A microvalve device comprises: a first substrate having a first surface, wherein at least one fluidic channel are formed into the first surface of the first substrate; and at least one valve seat are formed in the fluidic channel; a second substrate having a second surface, the second substrate comprising at least one air channel and at least one air chamber formed on the second surface of the second substrate, wherein the air chamber is connected to the air channel; and an elastic film interposed between the first substrate and the second substrate, where an upper portion of the valve seat is lower than the first surface of the first substrate. | 11-24-2011 |
20110300034 | Disposable, High Pressure Microfluidic Chips - An injection molding process for the fabrication of disposable unitary plastic microfluidic chips with a cycle time on the order of minutes is described. The microfluidic chips feature novel, integrated, reversible, standardized, ready-to-use inter-connects that enable operation at pressures not before realized with microfluidic chips. | 12-08-2011 |
20110305607 | MICROFLUIDIC DEVICE HAVING MICROVALVE - A microfluidic device including a microvalve includes a first substrate, a second substrate facing the first substrate, an elastic film between the first and second substrates, a microfluidic channel on the second substrate, a valve seat of the second substrate protruding in the microfluidic channel, and a fine structure on a surface of the elastic film, facing the valve seat and which contacts the valve seat when the microvalve is operated. | 12-15-2011 |
20120009098 | MICROFLUIDIC DEVICE WITH A FILTER - A microfluidic device with a filter includes a substrate; a flowpath including a well formed in the substrate in fluid communication with a channel formed in the substrate; and a filter disposed across the flowpath and associated with the channel. | 01-12-2012 |
20120027648 | INTERFACING CAPS FOR MICROFLUIDIC DEVICES AND METHODS OF MAKING AND USING THE SAME - An interfacing cap for a reagent storage vessel is provided. The interfacing cap comprises a partitioning element having a structure corresponding to an opening of the reagent storage vessel, a projection fitting disposed on the partitioning element, a holder element, and a puncturing element coupled to the projection fitting. | 02-02-2012 |
20120063971 | INERTIAL PARTICLE FOCUSING SYSTEM - An inertial particle focusing system for use with a particle having diameter (a) includes a curved microchannel into a substrate, said microchannel having a radius of curvature (r), and a channel hydraulic diameter (D | 03-15-2012 |
20120063972 | DEVICE HAVING REGIONS OF DIFFERING AFFINITIES TO FLUID, METHODS OF MAKING SUCH DEVICES, AND METHODS OF USING SUCH DEVICES - A microfluidic device comprising a first surface portion and a first sample retaining element, which have differing affinities to a fluid, and a method comprising supplying a sample to such a device. In some embodiments, the differing affinity is a result of plasma, ion embedding, surface charging, chemical, optical, electronic and/or electromagnetic treatment. Also, a microfluidic device comprising at least one microcapillary device having a sample retaining element, at least one surface of which exhibits hydrophobicity, hydrophilicity, electromagnetic force exertion and electrostatic force exertion. Also, a microfluidic device comprising a first element having a hydrophilic pattern comprising at least a first sample retaining element. Also, a method comprising supplying a sample to a channel between a first element and a second element, and inducing in the first element at least one hydrophilic pattern by electrets or by internal or external electrodes to provide a charged surface. | 03-15-2012 |
20120093700 | SILICON SUBSTRATE OPTIMIZATION FOR MICROARRAY TECHNOLOGY - A micro device includes a substrate and a structure configured to bind to an object or a material, or not to bind to an object or material. The structure has a roughness based on a roughness of the object or material. For example, a microarray includes a substrate and a well positioned in the substrate and configured to bind to a type of bead. The well has a roughness based on a roughness of the type of bead to which the well is configured to bind. The roughness of the well is controlled by controlling a position and number of striations in the side of the well. In another example, a moveable component of a micro device may have a roughness different from a roughness of an adjacent component, to reduce the likelihood of the moveable component sticking to the adjacent component. | 04-19-2012 |
20120107194 | CHANNEL AND METHOD OF FORMING CHANNELS - A device is made by forming sacrificial fibers on a substrate mold. The fibers and mold are covered with a first material. The substrate mold is removed, and the covered fibers are then removed to form channels in the first material. | 05-03-2012 |
20120107195 | METHOD OF PRODUCING MICROFLUIDIC DEVICES BASED ON A POLYMER - Disclosed is a method for producing a polymer-based microfluidic device, including: forming a microstructure on a lower polymer matrix; coating the lower polymer matrix with TiO | 05-03-2012 |
20120114534 | MICRO-FLUIDIC SYSTEM AND THE USE THEREOF - The invention relates to a micro-fluidic system comprising: a. a planar micro-fluidic device comprising a plurality of inlets and at least one outlet; b. a holder comprising a first part being provided with a plurality of channels having first ends and second ends, the holder comprising a fixing means for clamping the micro-fluidic device; c. sealing means being arranged to connect the plurality of inlets and the at least one out-let of the micro-fluidic device to the second ends of the plurality of channels, the sealing means being arranged such that a surface contact between the micro-fluidic device and the sealing means and a surface contact between the sealing means and the first part of the holder is established characterized in that the first part of the holder is optionally provided with a first recess for accommodating the planar micro-fluidic device, the second ends of the plurality of channels being located within the optional first recess and at least one second recess is provided for accommodating the sealing means, the second ends of the plurality of channels being located in the at least one second recess. The present invention also relates to the use of such a micro-fluidic systems at high pressures and high temperatures. | 05-10-2012 |
20120121480 | MICROFLUIDIC DEVICES FOR RELIABLE ON-CHIP INCUBATION OF DROPLETS IN DELAY LINES - The present invention relates generally to droplet creation, fusion and sorting, and incubation for droplet-based microfluidic assays. More particularly, the present invention relates to delay-lines, which allow incubation of reactions for precise time periods. More particularly, the present invention relates to delay lines for incubations up to three hours, while reducing back-pressure and dispersion in the incubation time due to the unequal speeds with which droplets pass through the delay line. | 05-17-2012 |
20120121481 | SCALE-UP OF FLOW-FOCUSING MICROFLUIDIC DEVICES - Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices. | 05-17-2012 |
20120141337 | FLUORESCENCE DETECTOR, FILTER DEVICE AND RELATED METHODS - A microfluidic filter is disclosed. The filter can be used with onchip fluid filtration such as whole blood filtration for microfluidic blood analysis. The filter is able to filter the necessary volume of fluid and in particular blood in an acceptable time frame. | 06-07-2012 |
20120164036 | MICROFLUIDIC DEVICES AND USES THEREOF - The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The design of the cartridges, microchips, and pneumatic manifolds can allow for the use of magnetic forces to capture magnetic beads in a chamber formed between the microchip and the cartridge or a chamber within the microchip. The devices of the invention can be used for mRNA amplification and purification. | 06-28-2012 |
20120183454 | HEAT-REDUCTION METHODS AND SYSTEMS RELATED TO MICROFLUIDIC DEVICES - The present relates to a system and method for preventing or reducing unwanted heat in a microfluidic of the device while generating heat in selected regions of the device. Current can be supplied to a heating element through electric leads that are designed so that the current density in the leads is substantially lower than the current density in the heating element. Unwanted heat in the microfluidic complex can be reduced by thermally isolating the electric leads from the microfluidic complex by, for example, running each lead directly away from the microfluidic complex. Unwanted heat can be removed from selected regions of the microfluidic complex using one or more cooling devices. | 07-19-2012 |
20120195809 | APPARATUS AND METHODS FOR MICROFLUIDIC APPLICATIONS - Non-rigid tape apparatus and fabrication methods for microfluidic processing applications such as gel electrophoresis are provided, where microfluidic processing is performed on selected areas. Parts of the tape are formed by high pressure plastic film forming. Membranes and other structures are self sealing during and after penetration by pipettes and electrical probes. Rigid exoskeleton elements protect the non-rigid parts during processing and facilitate transport of the tape. | 08-02-2012 |
20120195810 | MICROFLUIDIC DEVICES WITH REMOVABLE COVER AND METHODS OF FABRICATION AND APPLICATION - The present invention includes microfluidic systems having a microfabricated cavity that may be covered with a removable cover, where the removable cover allows at least part of the opening of the microfabricated cavity to be exposed or directly accessed by an operator. The microfluidic systems comprise chambers, flow and control channels formed in elastomeric layers that may comprise PDMS. The removable cover comprises a thermoplastic base film bonded to an elastomer layer by an adhesive layer. When the removable cover is peeled off, the chamber is at least partially open to allow sample extraction from the chamber. The chamber may have macromolecular crystals formed inside or resulting contents from a PCR reaction. The invention also includes a method for making vias in elastomeric layers by using the removable cover. The invention further includes methods and devices for peeling the peelable cover or a removable component such as Integrated Heater Spreader. | 08-02-2012 |
20120230886 | Microfluidic Cytochemical Staining System - The present invention provides devices and associated methods to facilitate multiplexed staining on a slide. The use of multiplexed staining on a single slide allows for more accurate disease diagnosis while also conserving sample. A PDMS based cytology overlay was created that is capable of coupling on-chip morphological, cytochemical, and immunological staining. Morphological and cytochemical staining of blood smears, along with immunostaining of lymph node imprints, was carried out to demonstrate the application of this microfluidic cytology chip (μCC) device. | 09-13-2012 |
20120230887 | DEVICES AND METHODS FOR INTERFACING MICROFLUIDIC DEVICES WITH MACROFLUIDIC DEVICES - The present disclosure is directed generally to devices and methods with the purpose of interfacing microfluidic devices with macrofluidic devices. Specifically, the present disclosure includes the de- | 09-13-2012 |
20120258025 | MICROFABRICATED DEVICES WITH COATED OR MODIFIED SURFACE AND METHOD OF MAKING SAME - A microfabricated device or component thereof, such as microfluidics or nanofluidics device having a uniform non-wetting or non-absorbing polymeric coating or surface modification formed on a surface thereof by ionisation or activation technology such as plasma processing, to produce a surface energy of less than 15 mNm | 10-11-2012 |
20120269701 | FLUIDIC CONNECTORS AND MICROFLUIDIC SYSTEMS - Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use. | 10-25-2012 |
20120275971 | MICROCHIP - A microchip includes a fluid circuit defined by a space formed in the microchip. A liquid present in the fluid circuit is moved to a desired position in the fluid circuit. The fluid circuit includes a first channel passing the liquid and a second channel passing the liquid passed through the first channel, and the first channel is arranged such that a first end corresponding to an end of the second channel is spaced apart from an inner wall of the second channel. | 11-01-2012 |
20120288422 | GLASS MICRO FLUIDIC DEVICE - A method of making a microfluidic device, includes: providing an optically transparent bottom substrate and an optically transparent top substrate, each made of glass. Recesses are made in the top substrate and the top and bottom substrates are bonded together. Then, material is removed from the top substrate to expose the recesses, and a lid is attached to the top substrate so as to cover the recesses whereby channels are formed. At least that surface of the lid facing towards the recesses in the top substrate has a surface roughness of <5 nm, preferably <2 nm. A microfluidic device, including a body of an optically transparent material, and at least one channel extending inside the body, the channels having a bottom surface, a top surface and side walls is also described. The top and bottom surfaces both exhibit surface a roughness <5 nm, preferably <2 nm. | 11-15-2012 |
20120301371 | MICROFLUIDIC ELEMENT FOR ANALYZING A LIQUID SAMPLE - A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample. | 11-29-2012 |
20120301372 | MICROCHIP AND METHOD OF PRODUCING MICROCHIP - A microchip is provided. The microchip (A) includes a substrate structure including a fluid channel ( | 11-29-2012 |
20120321536 | MICROFLUIDIC DEVICE COMPRISING A BIODEGRADABLE MATERIAL AND METHOD OF MAKING SUCH A MICROFLUIDIC DEVICE - A microfluidic device comprising a biodegradable material comprises, according to one embodiment, a body including one or more channels extending therethrough for passage of a fluid, where the body includes a first preform and a second preform bonded to the first preform. The first preform comprises a biodegradable material derived from a plant and the second preform defines a wall of each of the channels. According to another embodiment, the microfluidic device comprises a body having one or more channels extending therethrough for passage of a fluid, where the body comprises a biodegradable material and is a monolithic body including no seams. | 12-20-2012 |
20130004385 | MICROFLUIDIC CHANNEL FOR REMOVING BUBBLES IN FLUID - A microfluidic channel for effectively removing a gas from a fluid, and microfluidic apparatus including the same are provided. The microfluidic channel includes a first channel having a uniform cross-sectional area, and a second channel connected to the first channel and having a gradually expanded cross-sectional area. | 01-03-2013 |
20130004386 | FABRICATING MICROFLUIDIC STRUCTURES FOR BIOMEDICAL APPLICATIONS - Microfluidic structures featuring substantially circular channels may be fabricated by embossing polymer sheets. | 01-03-2013 |
20130028812 | METHODS AND SYSTEMS FOR ON DEMAND DROPLET GENERATION AND IMPEDANCE BASED DETECTION - The present invention pertains to methods and systems for on demand droplet generation and impedance based detection. The microfluidic system can utilize an electrical sensor for detecting an electrical property of a fluid and for generating an electrical signal indicating a change in the electrical property of the fluid; a droplet generator coupled to the electrical sensor configured to generate the droplet from the fluid in response to the electrical signal from the electrical sensor; and a microfluidic channel coupled to the droplet generator for receiving the droplet. The method for generating droplets involves measuring an electrical property of the fluid, transmitting an electrical signal indicative of the electrical property, and forming the droplets from the fluid based on the electrical signal. | 01-31-2013 |
20130045144 | Micro-Fluidic System - A micro-fluidic system comprising a micro-fluidic channel, which has a wall provided with a hole, within which a closing portion of a closing element extends; when the closing portion is arranged within the micro-fluidic channel, the passage of the liquid along the channel is interrupted; by deforming the closing element by suction the closing portion may be lifted and therefore allow the passage of liquid along the micro-fluidic channel. | 02-21-2013 |
20130071304 | MICROFLUIDIC DEVICE - A micro-fluidic device includes a filter cabinet, a first filtering unit and a second filtering unit. The filter cabinet includes a first path and a second path branched from the first path. The first path and the second path are formed within the filter cabinet so that a sample containing different kinds of targets can flow through the first path and the second path. The first filtering unit is installed in an upstream portion of the first path to filter the different kinds of targets from the sample, the first filtering unit configured to guide the different kinds of targets toward the second path. The second filtering unit is installed in the second path to receive the different kinds of targets from the first filtering unit and to filter the different kinds of targets on a size-by-size basis. | 03-21-2013 |
20130078163 | Deterministic High-Density Single-Cell Trap Array - A microfluidic platform for single-cell capture, stimulation, and imaging. It passively traps 4,000 single cells on a 4.5 mm | 03-28-2013 |
20130078164 | Device for Forming Drops in a Microfluidic Circuit - The invention relates to a device ( | 03-28-2013 |
20130115148 | Microchip and Method of Using the Same - A microchip including a first substrate with a groove formed on a substrate surface or a pass-through hole passing in a thickness direction of the substrate, and one or more second substrates laminated on a surface of the first substrate; the microchip including an optical measurement cuvette consisting of a space configured by the groove or the pass-through hole, and a substrate surface of the second substrate; wherein a side wall surface of the second substrate is positioned on an inner side than a side wall surface of the first substrate in at least one part of a side wall surface of the microchip, and a method of using the same are provided. | 05-09-2013 |
20130121892 | POLYMERIC SUBSTRATE HAVING AN ETCHED-GLASS-LIKE SURFACE AND A MICROFLUIDIC CHIP MADE OF SAID POLYMERIC SUBSTRATE - The present invention relates to a polymeric substrate having a glass-like surface, in particular an etched-glass-like surface and to a chip made of at least one such polymeric substrate. The present invention also relates to a method of providing a polymeric substrate with an etched-glass-like surface. Moreover, the present invention relates to a kit for manufacturing a chip using such polymeric substrate. Moreover, the present invention relates to the use of a polymeric substrate having a glass-like surface, in particular an etched-glass-like surface for manufacturing a chip. | 05-16-2013 |
20130129581 | MICRODROPLET-PRODUCING APPARATUS - [Name of the Document] The present invention provides an apparatus for producing micro liquid drops through fine channels which can produce a large amount of micro liquid drops at low costs in an efficient manner. The apparatus for producing micro liquid drops according to the present invention includes a fine channel substrate and a holder for holding the fine channel substrate. The fine channel substrate has a micro liquid drop discharge outlet formed at the center thereof; a plurality of micro liquid drop producing sections which are connected to the micro liquid drop discharge outlet via the fine channels and disposed on the respective circumference of M circles or polygons arranged around the micro liquid drop discharge outlet; first-liquid drawing inlets which are disposed on the circumference of a circle or polygon arranged around the micro liquid drop discharge outlet; up-to-Nth-liquid drawing inlets (N is an integer equal to two or greater, M≦N−1) which are disposed on the respective circumference of circles or polygons arranged sequentially outward; and the fine channels through which the first- to Nth-liquids are supplied to the plurality of micro liquid drop producing sections. The holder for holding the fine channel substrate has a multi-pipe structure which includes N annular channels for distributing an equal flow of the first- to Nth-liquids to the drawing inlet for each liquid in the fine channel substrate. | 05-23-2013 |
20130149214 | MICROVASCULAR FLUIDIC DEVICES, SYSTEMS AND METHODS RELATED THERETO - Microfluidic devices and processes are provided that relate to microvascular-sized systems configured to identify specific pathophysiological characteristics related to the interactions between, for example, blood cells and endothelial cells combined with geometric and flow constraints of microvasculature. The device may include at least one layer, the layer including a plurality of microvascularized-sized fluidic channels, the plurality of microfluidic channels being disposed in a geometric pattern. The layer may be composed of a hydrogel and/or a silicon elastomer. The channels may include subchannels of different lengths. | 06-13-2013 |
20130149215 | SYSTEM-IN-PACKAGE PLATFORM FOR ELECTRONIC-MICROFLUIDIC DEVICES - The present invention relates to an integrated electronic-microfluidic device an integrated electronic-microfluidic device, comprising a semiconductor substrate ( | 06-13-2013 |
20130156657 | DEVICE AND METHOD FOR MANUFACTURING THE SAME - It is an object of this invention to prevent a resistor material and an electrode material from diffusing and suppress variation in electric resistance. In a device including a plurality of metal layers of different compositions on a substrate and a second structure made of a material, such as glass paste, requiring a firing process at the time of formation, an intermediate layer is formed between a first metal layer and a second metal layer forming the first structure. The intermediate layer is of an intermetallic compound including one or more metallic elements in the first metal layer and one or more metallic elements in the second metal layer. The melting point of the intermetallic compound is higher than a firing temperature when the second structure is formed, and the intermetallic compound is produced at a temperature higher than the firing temperature for forming the second structure. | 06-20-2013 |
20130164191 | MICROFLUIDIC DEVICES WITH INTEGRATED RESISTIVE HEATER ELECTRODES INCLUDING SYSTEMS AND METHODS FOR CONTROLLING AND MEASURING THE TEMPERATURES OF SUCH HEATER ELECTRODES - The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, a microfluidic device is provided that includes a microfluidic chip having a plurality of microfluidic channels and a plurality of multiplexed heater electrodes, wherein the heater electrodes are part of a multiplex circuit including a common lead connecting the heater electrodes to a power supply, each of the heater electrodes being associated with one of the microfluidic channels. The microfluidic device also includes a control system configured to regulate power applied to each heater electrode by varying a duty cycle, the control system being further configured to determine the temperature of each heater electrode by determining the resistance of each heater electrode. | 06-27-2013 |
20130164192 | Microfluidic Capsule - A microfluidic capsule ( | 06-27-2013 |
20130209326 | MICROFLUIDIC CARTRIDGE FOR PROCESSING AND DETECTING NUCLEIC ACIDS - A microfluidic cartridge, configured to facilitate processing and detection of nucleic acids, comprising: a top layer comprising a set of cartridge-aligning indentations, a set of sample port-reagent port pairs, a shared fluid port, a vent region, a heating region, and a set of Detection chambers; an intermediate substrate, coupled to the top layer comprising a waste chamber; an elastomeric layer, partially situated on the intermediate substrate; and a set of fluidic pathways, each formed by at least a portion of the top layer and a portion of the elastomeric layer, wherein each fluidic pathway is fluidically coupled to a sample port-reagent port pair, the shared fluid port, and a Detection chamber, comprises a turnabout portion passing through the heating region, and is configured to be occluded upon deformation of the elastomeric layer, to transfer a waste fluid to the waste chamber, and to pass through the vent region. | 08-15-2013 |
20130236374 | FLUID CARTRIDGE AND SYSTEM FOR DISPENSING FLUID - A fluid cartridge has a bottle to retain a volume of fluid. An ejector chip resides in fluid communication with the bottle and causes ejection of fluid upon activation of fluid ejectors. Control logic coordinates ejector activation with dose control logic and temperature control circuitry. The dose control logic pre-specifies an amount of fluid to be ejected and prevents further ejection upon reaching the amount. Meanwhile, the temperature control circuit inhibits any ejection until a temperature of the fluid is within a predefined acceptable range. Bottle modularity, fluid dispense-areas and group-control of the ejectors facilitate certain designs. | 09-12-2013 |
20130236375 | FLUID MIXING AND DELIVERY IN MICROFLUIDIC SYSTEMS - The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user. | 09-12-2013 |
20130243663 | DIRECT SEALING OF GLASS MICROSTRUCTURES - Embodiments of methods for sealing a glass microstructure assembly comprise providing one or more side retainer members on a base plate adjacent the glass microstructure assembly, the side retainer members having a height less than an uncompressed height defined by the glass microstructure assembly. The methods also comprise compressing the glass microstructure assembly via a load bearing top plate in intimate contact with the top glass layer while heating the glass microstructure assembly and the top plate to a glass sealing temperature, the glass sealing temperature being a temperature sufficient to make glass viscous, wherein the glass microstructure assembly is compressed until the load bearing top plate contacts the side retainer members, and wherein the lower surface of the top plate maintains adhesion to the upper surface of the top glass layer at the glass sealing temperature while the load bearing plate is supported by the side retainer members. | 09-19-2013 |
20130251602 | HEAT-REDUCTION METHODS AND SYSTEMS RELATED TO MICROFLUIDIC DEVICES - The present relates to a system and method for preventing or reducing unwanted heat in a microfluidic of the device while generating heat in selected regions of the device. Current can be supplied to a heating element through electric leads that are designed so that the current density in the leads is substantially lower than the current density in the heating element. Unwanted heat in the microfluidic complex can be reduced by thermally isolating the electric leads from the microfluidic complex by, for example, running each lead directly away from the microfluidic complex. Unwanted heat can be removed from selected regions of the microfluidic complex using one or more cooling devices. | 09-26-2013 |
20130251603 | SAMPLE PACKING DEVICE - Provided is a sample packing device for packing a sample with respect to a microchip for performing reaction of a micro component contained in the sample, the microchip at least including: a sample reservoir; a reaction reservoir; and a channel connected between the sample reservoir and the reaction reservoir, in which a package including a sample chamber packed in advance with the sample is mounted on the microchip so as to pack the sample in the sample chamber into the sample reservoir. | 09-26-2013 |
20130280144 | Microchip - A microchip including a fluid circuit formed by a groove of a first substrate and a surface of a second substrate is provided. The fluid circuit includes a fluid retaining reservoir for containing a fluid. The fluid retaining reservoir includes a fluid outlet or outflow channel for allowing the fluid to flow out, and a partition dividing the fluid retaining reservoir into a first region including a fluid inlet for injecting a fluid into the fluid retaining reservoir and a second region including the fluid outlet or outflow channel. The partition includes at least one communication gate for allowing communication between the first region and the second region. | 10-24-2013 |
20130287645 | MICROFLUIDIC CHAMBER DEVICE AND FABRICATION - A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. Methods for fabricating the subassembly and assembled flow cell are also provided. The method includes the steps of adhering a gasket layer to a substrate layer, wherein the gasket layer may contain enclosed features and adhering an adherent layer to the gasket layer. The subassembly may be sealed against a solid support to form a flow cell. | 10-31-2013 |
20130287646 | Microchip - A microchip including a fluid circuit formed by a groove of a first substrate and a surface of a second substrate is provided. The fluid circuit includes a fluid retaining reservoir for containing a fluid. The fluid retaining reservoir includes a fluid outlet or outflow channel for allowing the fluid to flow out, and a partition dividing the fluid retaining reservoir into a first region including a fluid inlet for injecting a fluid into the fluid retaining reservoir and a second region including the fluid outlet or outflow channel. The partition includes at least one communication gate for allowing communication between the first region and the second region. | 10-31-2013 |
20130294981 | LIQUID CHANNEL DEVICE AND PRODUCTION METHOD THEREFOR - The present invention relates to a liquid channel device capable of easily opening the liquid channel from the closed mode, including a base plate in which a liquid channel, through which a liquid containing at least one of a sample and a reagent, flows, and a metering chamber for holding the liquid, are formed to at least one side thereof, the metering chamber has a liquid transport section for transporting the liquid inside the chamber downstream, and this liquid transport section is operated by means of external pressing on a cover plate in the area opposite the metering chamber. | 11-07-2013 |
20130330245 | MOBILE WATER ANALYSIS - An embodiment provides a cuvette apparatus including: a lid and a body, the body including a fluid channel disposed therein; and the lid including at least one opening aligned with a portion of the fluid channel, thereby providing access to the fluid channel in the body. Other aspects are described and claimed. | 12-12-2013 |
20140010734 | Modular Computer-Controlled Multistep Chemical Processing System for Use in Laboratory Automation or Chemical Production - A modular laboratory-style computer-controlled system for multistep chemical processing for use in laboratory automation or chemical production is disclosed. The system comprised a plurality of interconnectable electrically-powered controllable chemical process modules having chemical input and output ports and at least one communications interface. Interconnection among the chemical process modules include both chemical flow interconnections for the transport of chemical materials and network interconnections for the transport of communications signals. The controllable chemical process modules have distinct network addresses and are controlled by an algorithm executed by the data processor. In some implementations chemical flow interconnections are software controllable. In some implementations the system further comprises feedback control. In some implementations some chemical process modules comprise sensors responsive to sense physical quantities. | 01-09-2014 |
20140017149 | Sheath flow method and apparatus for laminar flow systems - A sheath flow system having a channel with first and second fluid transporting structures located on opposing surfaces facing one another across the channel in the top and bottom surfaces of the channel situated so as to transport the sheath fluid laterally across the channel to provide sheath fluid fully surrounding the core solution. At the point of introduction into the channel, the sheath fluid and core solutions flow side by side within the channel or the core solution may be bounded on either side by the sheath fluid. The system is functional over a broad channel size range and with liquids of high or low viscosity. The design can be readily incorporated into microfluidic chips without the need for special manufacturing protocols | 01-16-2014 |
20140023564 | MICROFLUIDIC STORAGE DEVICE FOR PRE-STORING OF FLUID, METHOD FOR ITS PRODUCTION AND A USE THEREOF - A microfluidic storage device for pre-storing a fluid includes a first substrate, a second substrate, and a membrane. The first substrate has a recess formed in a first surface. The second substrate has a second surface formed to form fit with the first surface at least in subregions outside the recess. The membrane is arranged between the first and second substrates and is in contact with the first and second surfaces in regions outside the recess. In the region of the recess, the membrane is configured to line the recess so that a volume region inside the recess, between the membrane and the second substrate, can be filled with the fluid. The first substrate, the membrane, and the second substrate are configured to be joined together at least in subregions, outside the recess, in which the membrane is in contact with the first and second surfaces. | 01-23-2014 |
20140023565 | REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND METHODS - Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration. | 01-23-2014 |
20140030165 | MICROFLUIDIC DEVICES HAVING SOLVENT-RESISTANT COATING AND METHOD OF MANUFACTURE THEREOF - A method of coating a substrate, such as a microfluidic device having an interior surface, includes heating a gas including a perfluoroacrylate, a crosslinker and an initiator at a first temperature, maintaining the substrate at a second temperature lower than the first temperature in a reaction chamber, exposing the heated gas to the substrate in the reaction chamber, and reacting the perfluoroacrylate with the initiator and crosslinker to form a polymer coating on the surface of the substrate. | 01-30-2014 |
20140037514 | METHOD AND APPARATUS FOR FLUID DISPERSION - A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques. | 02-06-2014 |
20140037515 | MICROFLUIDIC CARD CONNECTION DEVICE - A device for interconnecting a card including at least one first fluid channel, emerging from a connection side parallel to a support side, the interconnection device including: a first surface configured to receive the support side of the card; a second surface parallel to the first surface, from which a second fluid channel emerges; and a mechanism to hold the card in place, configured to hold a connection side of the card pressed against the second surface of the device, such that first fluid channel is in fluid connection with the second fluid channel. | 02-06-2014 |
20140044610 | MICROFLUIDIC DEVICE - The present invention provides a microfluidic device which is molded with a die and has a specimen inlet part. The microfluidic device has the specimen inlet part. The specimen inlet part has an inlet channel for introducing a specimen into the flow channel, wherein the inlet channel has a diameter which continuously and gradually increases as the inlet channel approaches the flow channel, or has a diameter which is constant in the vicinity of an inlet port and then continuously and gradually increases as the inlet channel approaches the flow channel. | 02-13-2014 |
20140065034 | MICROFLUIDIC DEVICE AND METHOD OF FABRICATING MICROFLUIDIC DEVICES - Lab-on-a-chip microfluidic devices having micro-channels able to withstand an internal channel pressure of more than 4,000 psi are described. The micro-channels have rounded cross-sections that prevent turbulent flow within a fluid conveyed within the channel. The channel may have serpentine-shaped length extending between a channel inlet and a channel outlet, the channel thereby being of sufficient length to observe both the stationary and moving phases of the fluid in a chip having a sufficiently small footprint that it is suitable for incorporation into a miniaturized spectrometer. Methods of fabricating lab-on-a-chip microfluidic devices are described by etching recesses in chip substrates such that a first substrate recess mirrors a second substrate recess in an opposed orientation, aligning the substrates such the recesses cooperatively define a micro-channel having a rounded cross-section, and bonding the substrates to define a smooth-walled micro-channel. | 03-06-2014 |
20140065035 | METHOD FOR MANUFACTURING A MICROVALVE DEVICE MOUNTED ON A LAB-ON-A-CHIP, AND MICROVALVE DEVICE MANUFACTURED BY SAME - The present invention relates to a method for manufacturing a microvalve device of a lab-on-a-chip by interposing a polyvinylidene chloride film between upper and lower substrates, each of which is produced by injection molding of a rigid polymer resin, and heating and pressurizing the resultant structure. The present invention also relates to a microvalve device manufactured by the method. According to the method of the present invention, each of the upper and lower substrates can be produced by injection molding of a rigid polymeric material, thus being appropriate for mass production in a short time. Excellent thermal bonding properties between the polyvinylidene chloride film and the substrates enable the formation of the rigid substrate/film membrane/rigid substrate structure in an easy and reliable manner, which shortens the time required to manufacture the microvalve device. Therefore, the method of the present invention is suitable for the mass production of labs-on-a-chip. In addition, the polyvinylidene chloride film does not droop upon thermal pressing due to its thermal shrinkage. Therefore, the polyvinylidene chloride film does not fill a fine shape and the shape thereof remains unchanged. The shape of the film membrane is curved by the application of a vacuum, which ensures smooth and sensitive opening/closing operations. The polyvinylidene chloride film prevents mixing of fluids flowing on and under the film membrane due to its low fluid permeability. Therefore, the polyvinylidene chloride film is suitable as a valve or pump. | 03-06-2014 |
20140079602 | FLUID HANDLING APPARATUS - Microchannel chip ( | 03-20-2014 |
20140147346 | LASER TREATMENT OF A MEDIUM FOR MICROFLUIDS AND VARIOUS OTHER APPLICATIONS - A patterned circuit, including a hydrophilic substrate, a hydrophobic layer formed on the hydrophilic substrate, and a pattern formed in the hydrophobic layer to expose the hydrophilic substrate. | 05-29-2014 |
20140161685 | DROPLET-GENERATING METHOD AND DEVICE - A droplet-generating device is provided. The droplet-generating device comprises a first microchannel and a second microchannel. The first microchannel includes a first fluid inlet and a second fluid inlet. The second microchannel crossing over and communicating with the first microchannel at an intersectional region includes a third fluid inlet, a fourth fluid inlet, a fluid outlet, a three-way junction and a side wall. The intersectional region is configured between the third fluid inlet and the three-way junction, and the side wall is disposed between the fourth fluid inlet and the fluid outlet and extended downward. A method of producing a droplet is also provided. | 06-12-2014 |
20140161686 | SYSTEM AND METHOD OF DISPENSING LIQUIDS IN A MICROFLUIDIC DEVICE - Microfluidic system including a droplet actuator having an interior cavity and a series of electrodes arranged along the interior cavity for forming a droplet-operation path therethrough. The droplet actuator has a module-engaging side including an opening that is in flow communication with the interior cavity. The microfluidic system also includes a reservoir module configured to be coupled to the droplet actuator. The reservoir module includes a plurality of liquid compartments having respective outlets and at least one seal positioned along the outlets to retain liquid within the liquid compartments. The reservoir module is movable along the module-engaging side of the droplet actuator to position the outlets relative to the opening. The microfluidic system also includes a piercer having a tip configured to penetrate the seal thereby permitting the liquid within the corresponding liquid compartment to flow into the opening. | 06-12-2014 |
20140193310 | POROUS CATALYTIC SUBSTRATE - Some embodiments in the present disclosure generally relate to catalytic silica-polyvinyl alcohol composites, silica structures therefrom, and/or microreactors therefrom. Some embodiments in the present disclosure generally relate to porous substrates that can have at least one pore with a catalyst associated with the inside of the pore. | 07-10-2014 |
20140193311 | INTEGRATED HIGH THROUGHPUT SYSTEM FOR THE ANALYSIS OF BIOMOLECULES - Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules. | 07-10-2014 |
20140234180 | SYSTEMS AND DEVICES FOR ANALYSIS OF SAMPLES - Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described. | 08-21-2014 |
20140255270 | REMOVING SACRIFICIAL LAYER TO FORM LIQUID CONTAINMENT STRUCTURE AND METHODS OF USE THEREOF - A method of forming a liquid handling device includes forming a device precursor having a containment structure with a surface that surrounds a containment gap that is occupied by a solid sacrificial layer. The method also includes removing the solid sacrificial layer from the containment gap. In some instances, removing the solid sacrificial layer includes thermally decomposing the solid sacrificial layer. | 09-11-2014 |
20140271402 | FLUIDICS SYSTEM FOR SEQUENTIAL DELIVERY OF REAGENTS - The invention provides a passive fluidics circuit for directing different fluids to a common volume, such as a reaction chamber or flow cell, without intermixing or cross contamination. The direction and rate of flow through junctions, nodes and passages of the fluidics circuit are controlled by the states of upstream valves (e.g. opened or closed), differential fluid pressures at circuit inlets or upstream reservoirs, flow path resistances, and the like. Free diffusion or leakage of fluids from unselected inlets into the common outlet or other inlets at junctions or nodes is prevented by the flow of the selected inlet fluid, a portion of which sweeps by the inlets of unselected fluids and exits the fluidics circuit by waste ports, thereby creating a barrier against undesired intermixing with the outlet flow through leakage or diffusion. The invention is particularly advantageous in apparatus for performing sensitive multistep reactions, such as pH-based DNA sequencing reactions. | 09-18-2014 |
20140308178 | Microfluidic Mixing and Reaction Systems for High Efficiency Screening - Microfluidic devices are described that include a rigid base layer, and an elastomeric layer on the base layer. The elastomeric layer may include at least part of a fluid channel for transporting a liquid reagent, and a vent channel that accepts gas diffusing through the elastomeric layer from the flow channel and vents it out of the elastomeric layer. The devices may also include a mixing chamber fluidly connected to the fluid channel, and a control channel overlapping with a deflectable membrane that defines a portion of the flow channel, where the control channel may be operable to change a rate at which the liquid reagent flows through the fluid channel. The devices may further include a rigid plastic layer on the elastomeric layer. | 10-16-2014 |
20140322099 | MICROFLUIDIC CHIPS AND ASSAY SYSTEMS - The systems and methods described herein include a microfluidic chip having a plurality of microfeatures interconnected to provide a configurable fluid transport system for processing at least one reagent. Inserts are provided to removably interfit into one or more of the microfeatures of the chip, wherein the inserts include sites for interactions with the reagent. As will be seen from the following description, the microfluidic chip and the inserts provide an efficient and accurate approach for conducting parallel assays. | 10-30-2014 |
20140328732 | Apparatus and Cartridge for Hemostasis Testing - A sample testing cartridge is usable to perform a variety of tests on a visco-elastic sample, such hemostasis testing on a whole blood or blood component sample. The cartridge includes a sample processing portion that is in fluid communication with a sample retention structure. A suspension, such as a beam, arm, cantilever or similar structure supports or suspends the sample retention portion relative to the sample processing portion in a unitary structure. In this manner, the sample retention portion may be placed into dynamic excitation responsive to excitation of the cartridge and correspondingly dynamic, resonant excitation of the sample contained within the sample retention portion, while the sample processing portion remains fixed. Observation of the excited sample yields data indicative of hemostasis. The data may correspond to hemostasis parameters such as time to initial clot formation, rate of clot formation, maximum clot strength and degree of clot lysis. | 11-06-2014 |
20140369901 | Flexible Microreactors - The present application for patent is in the field of microreactors and more specifically in the field of microreactors which are prepared from flexible substrates. Methods of preparing flexible substrates using various printing methods are also disclosed. | 12-18-2014 |
20150037226 | MICROFLUIDIC DEVICE AND METHOD OF PRODUCING THE SAME - A microfluidic device and a method of producing the microfluidic device are provided. The microfluidic device includes an upper substrate and a lower substrate fixed to each other to form a microfluidic structure, and a hydrophobic porous layer disposed between the upper substrate and the lower substrate, and configured to fix the upper and lower substrates and absorb air within the microfluidic structure. | 02-05-2015 |
20150044110 | MICROFLUIDIC DEVICE WITH HYDROPHOBIC SURFACE MODIFICATION LAYER AND MANUFACTURING METHOD THEREOF - A microfluidic device includes a support body having a first surface and a second surface opposite to one another. The first surface is hydrophilic. A surface modification layer extends over the first surface of the support body. At least one opening is formed to extend through the surface modification layer and expose a portion of the first surface. The surface modification layer is hydrophobic. In particular, the surface modification layer is made of a photodefinible material chosen from among: an epoxy resin, a polyamide, and a photocurable siloxane-based polymer. The openings are functionalized using probe molecules designed to bind with specific target molecules to be detected. | 02-12-2015 |
20150086443 | MICROFLUIDIC CHIPS WITH MICRO-TO-MACRO SEAL AND A METHOD OF MANUFACTURING MICROFLUIDIC CHIPS WITH MICRO-TO-MACRO SEAL - A microfluidic chip for a microfluidic system includes a micro-to-macro seal. The microfluidic chip has a substrate, at least one microfluidic pathway in the substrate, and a PDMS seal layer on the substrate and above the microfluidic pathway. The PDMS seal layer provides a seal above the microfluidic pathway and prevent particles or contaminants entering the micro-channel during transportation or prior to application. During application, a needle or piping pierces through the PDMS seal layer, and fluid can be pumped into the microfluidic chip without concern for the fluid leaking despite high pressure required to pump or drive the fluid into the microfluidic pathway. | 03-26-2015 |
20150086444 | METHOD OF PRODUCING FLOW PASSAGE DEVICE AND FLOW PASSAGE DEVICE - A flow passage device includes a first base body having a first hole and a second base body having a second hole connected to the first hole to form a flow passage. A first portion formed around the first hole has a specified shape for holding an adhesive. The second base body has a high-wettability surface around the second hole with a low-wettability surface disposed proximate the high-wettability surface, and at least part of the high-wettability surface has a shape matching at least part of the specified shape. The first and second base body are bonded to each other with the adhesive to form the flow passage by aligning the at least part of the first portion with the at least part of the high-wettability surface with positions of the first and the second holes aligned with each other. | 03-26-2015 |
20150110688 | CHANNEL DEVICE AND METHOD FOR FABRICATING THE SAME - A method for fabricating a channel device that is formed by bonding a first substrate having a first adhesion surface to a second substrate having a second adhesion surface, the second adhesion surface having a plurality of grooves that become channel wall surfaces, the method including a first step of forming a layer of a liquid composed of a curable adhesive between the first adhesion surface and the second adhesion surface; a second step of forming menisci of the liquid in the vicinities of wall surfaces of the plurality of grooves after the first step by applying a pressure to bring the first adhesion surface and the second adhesion surface close to each other; and a third step of curing the adhesive while the first adhesion surface and the second adhesion surface are close to each other. | 04-23-2015 |
20150290642 | METHOD FOR CONNECTING COMPONENTS OF A MICROFLUIDIC FLOW CELL - A flow cell and a method for connecting components of a microfluidic flow cell, in particular for integrating component parts into a carrier structure of the flow cell, in which a gap is formed between the components to be connected. The gap is filled with a solvent. The material of at least one component bordering the gap dissolves in the solvent and the material completely fills the width of the gap and partially fills the height thereof after evaporation of the solvent. | 10-15-2015 |
20150290644 | Electromechanical and Fluidic Interface To A Microfluidic Substrate - A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate. | 10-15-2015 |
20150298127 | FLUIDIC CHIP AND WASTE LIQUID PROCESSING METHOD FOR SAME - Disclosed is a fluidic chip or the like comprising a structure that does not leak a fluid to the exterior. This fluidic chip has at least two elastic members layered in an intermediate layer provided between a top substrate and a bottom substrate. An attached region, in which the elastic members are mutually attached, and a first non-attached region, in which the elastic members are not attached, are provided between the elastic member layers, and a recess in which a fluid can be stored is formed in the top substrate. In addition, the fluidic chip is provided with a through-hole that communicates between the bottom of the recess and one elastic member, of the at least two elastic members, that is attached to the top substrate side. A channel for the fluid is formed by mutual separation of the layers that form the first non-attached region in accordance with the pressurization by the fluid. The fluid that passes through the region is stored in the recess via the through-hole. | 10-22-2015 |
20150343440 | METHOD OF BONDING FLUID DEVICE - Provided is a device including: a first substrate having a flat surface; a second substrate having a flat surface; and a recessed portion formed in at least one of the flat surfaces of the first substrate and the second substrate, the flat surfaces of the first substrate and the second substrate being bonded together using a solvent to form a hollow therebetween in which a contact angle between a portion of the flat surface in contact with the hollow and the solvent is larger than a contact angle between at least part of a portion of the flat surface that is not in contact with the hollow and the solvent. | 12-03-2015 |
20150352548 | ADDRESSABLE ACTUATOR SYSTEM - Microfluidic chips may include one or more microfluidic elements and one or more channels providing fluid communication throughout the microfluidic chip. The microfluidic chips may also include an identifier for identifying a predetermined configuration of the one or more microfluidic elements and the one or more channels from a set of predetermined different configurations of the one or more microfluidic elements and the one or more channels. | 12-10-2015 |
20150352551 | Test Cartridge with Integrated Transfer Module - A system that includes a cartridge housing and a hollow transfer module, according to an embodiment is described herein. The cartridge housing further includes at least one sample inlet, a plurality of storage chambers, a plurality of reaction chambers, and a fluidic network. The fluidic network is designed to connect the at least one sample inlet, a portion of the plurality of storage chambers and the portion of the plurality of reaction chambers to a first plurality of ports located on an inner surface of the cartridge housing. The hollow transfer module includes a second plurality of ports along an outer surface of the transfer module that lead to a central chamber within the transfer module. The transfer module is designed to move laterally within the cartridge housing. The lateral movement of the transfer module aligns at least a portion of the first plurality of ports with at least a portion of the second plurality of ports. | 12-10-2015 |
20150367344 | MICROFLUIDIC DEVICE - A microfluidic device of the present invention is connected to at least an inlet to permit at least a stream of fluid with a desired fluid flow rate and a stable laminar flow. A body with at least a non-deformable portion and a deformable portion is connected to the inlet. At least a microconduit of substantially reduced length and cross-section, integrally formed in said non-deformable and deformable portions, and connected to the inlet. The stable laminar flow of fluid transiting through the microconduit is disrupted, resulting in a turbulent flow of the fluid, with a vibration of the deformable portion, when the fluid flow rate crosses a threshold value. The turbulent flow of the fluid undergoes an enhanced mixing, in a reduced period of time. At least an outlet is connected to microconduit to collect the mixed fluid. A network of microfluidic devices are arranged to perform mixing of fluids. | 12-24-2015 |
20150375227 | Microfabricated Crossflow Devices and Methods - This invention provides microfabricated devices and methods for detecting, analyzing and sorting biological materials and particles. Droplets containing the particles are provided in an extrusion fluid, passed through a detection region, and then directed into a branch channel according to predetermined characteristics. For example, cells or viral particles contained in droplets of aqueous solvent are flowed past a detector in the nonpolar extrusion fluid decane, and routed into a selected branch channel for subsequent analysis or use. | 12-31-2015 |
20160001287 | MICROCHIP AND METHOD OF PRODUCING MICROCHIP - A microchip is provided. The microchip includes a substrate structure including a fluid channel configured to contain a sample solution, wherein the fluid channel is maintained at a pressure lower than atmospheric pressure prior to injection of the sample solution into the fluid channel. | 01-07-2016 |
20160016164 | Microfluidic Devices With Removable Cover and Methods of Fabrication and Application - The present invention includes microfluidic systems having a microfabricated cavity that may be covered with a removable cover, where the removable cover allows at least part of the opening of the microfabricated cavity to be exposed or directly accessed by an operator. The microfluidic systems comprise chambers, flow and control channels formed in elastomeric layers that may comprise PDMS. The removable cover comprises a thermoplastic base film bonded to an elastomer layer by an adhesive layer. When the removable cover is peeled off, the chamber is at least partially open to allow sample extraction from the chamber. The chamber may have macromolecular crystals formed inside or resulting contents from a PCR reaction. The invention also includes a method for making vias in elastomeric layers by using the removable cover. The invention further includes methods and devices for peeling the peelable cover or a removable component such as Integrated Heater Spreader. | 01-21-2016 |
20160016167 | LIQUID FEEDER AND CHEMICAL ANALYZER INCLUDING SAME - The liquid feeding device includes a branched portion at which a fluid is branched into a main flow passage that feeds the fluid from an upstream side to a downstream side and a first flow passage being branched from the main flow passage;
| 01-21-2016 |
20160089671 | METHOD AND APPARATUS FOR TAPED INTERLAYER FLOW CELL WITH MASKING AND CONDUCTIVE TRACES - A flow cell incorporates a first substrate with a metal layer on one surface. A tape layer having flow channels is adhered to the first substrate. A second substrate having a second metal layer on one surface is adhered to the tape layer opposite the first substrate. At least one of the first and second metal layers includes mating cutouts to at least partially expose the flow channels. | 03-31-2016 |
20160116393 | PARTICLE ARRANGING DEVICE AND METHOD - A particle arranging device includes a chamber including a first input/output portion and a second input/output portion and providing a space through which a fluid containing particles flows, at least one capturing structure provided in the chamber to form a fluidic channel through which the fluid flows and having a gate portion adapted to allow the particle in the fluid to enter the capturing structure through the gate portion and a receiving portion adapted to receive the particle entering through the gate portion, a deformable membrane structure provided in the gate portion of the capturing structure and configured to actuate to control the number of the particles to enter the capturing structure through the gate portion, and a membrane control portion configured to apply a pressure to the deformable membrane structure. | 04-28-2016 |
20160129439 | DIAGNOSTIC ELEMENT, AND A DIAGNOSTIC DEVICE COMPRISING A DIAGNOSTIC ELEMENT - The invention relates to a diagnostic element. The diagnostic element comprises an inlet passage, a holding port and an outlet passage. The holding port is capable of encapsulating a diagnostic gel. The invention also relates to a diagnostic device that comprises at least one inlet port, a preparation port, a diagnostic element that comprises an inlet passage, a holding port, an outlet passage and an outlet port. | 05-12-2016 |
20160129440 | MICROFLUIDIC STRUCTURES FOR BIOMEDICAL APPLICATIONS - Microfluidic structures featuring substantially circular channels may be fabricated by embossing polymer sheets. | 05-12-2016 |
20160129442 | MICROFLUIDIC MIXING AND REACTION SYSTEMS FOR HIGH EFFICIENCY SCREENING - Microfluidic devices are described that include a rigid base layer, and an elastomeric layer on the base layer. The elastomeric layer may include at least part of a fluid channel for transporting a liquid reagent, and a vent channel that accepts gas diffusing through the elastomeric layer from the flow channel and vents it out of the elastomeric layer. The devices may also include a mixing chamber fluidly connected to the fluid channel, and a control channel overlapping with a deflectable membrane that defines a portion of the flow channel, where the control channel may be operable to change a rate at which the liquid reagent flows through the fluid channel. The devices may further include a rigid plastic layer on the elastomeric layer. | 05-12-2016 |
20160136638 | MICROFLUIDIC DEVICE, PROCESS FOR PRODUCING THE SAME, AND CHANNEL-FORMING PHOTOSENSITIVE RESIN COMPOSITION - The invention is a microfluidic devices having a channel that is microscopic but is free from the risk of the attachment of substrates. A microfluidic device includes a channel in a body, and the channel has a patterned resin composition layer formed from a photosensitive resin composition including an oxiranyl group-containing compound, an oxetanyl group-containing compound and a photoacid generator. | 05-19-2016 |
20160158754 | PHOTO-RESPONSIVE SPIROPYRAN-BASED N-ISOPROPYLACRYLAMIDE (NIPAM) GELS - The present teaching relates to photo-responsive hydrogels comprising a copolymer comprising N-isopropylacrylamide (NIPAM), a polymerisable derivative of benzospiropyran, a cross-linking agent and an acid, the acid having a pKa of less than 6, wherein the hydrogel is operably responsive to exposure to water so as to undergo spontaneous protonation and swelling. The photo-responsive hydrogels described can be used in the field of microfluidic platforms. | 06-09-2016 |
20160167048 | APPARATUS AND METHODS FOR CREATING A STATIC AND TRAVERSING THERMAL GRADIENT ON A MICROFLUIDIC DEVICE | 06-16-2016 |
20160167050 | A Valve which Depressurises, and a Valve System | 06-16-2016 |
20160175840 | Microfluidic Cartridge Assembly | 06-23-2016 |
20160184789 | MICROCHEMICAL CHIP AND REACTION DEVICE - A simple and compact microchemical chip has a fine flow path formed therein through which a specimen is made to flow; is break resistance; makes it possible to flow the fluid sample to the flow path; makes it possible to analyze a useful substance and cause it to react; and can be produced with a high yield. A microchemical chip includes: a rubber sheet having a penetrated flow path which chemically reacts a pressurized fluid sample selected from a specimen and a reagent by flowing thereinto; substrate sheets which sandwich the rubber sheet and bond to both faces thereof by direct bond or by chemical bond through a silane-coupling agent and are selected from metal, ceramics, glass, and resin; and a hole for injecting the fluid sample into the flow path and a hole for draining the fluid sample flowed therefrom which are opened into the substrate sheet. | 06-30-2016 |
20160184823 | DIGITAL MICROFLUIDIC DILUTION APPARATUS, SYSTEMS, AND RELATED METHODS - Example methods, apparatus, systems for diluting samples are disclosed. An example method includes depositing a first fluid droplet on a first electrode of a plurality of electrodes. The first electrode has a first area. The first fluid droplet has a first volume associated with the first area. The example method includes depositing a second fluid droplet on a second electrode of the plurality of electrodes. The second electrode has a second area. The second fluid droplet has a second volume associated with the second area. The second volume is different than the first volume. The example method includes forming a combined droplet by selectively activating at least one of the first electrode or the second electrode to cause one of the first fluid droplet or the second fluid droplet to merge with the other of the first fluid droplet or the second fluid droplet. | 06-30-2016 |
20160184824 | HIGH THROUGHPUT SCREENING OF CRYSTALLIZATION OF MATERIALS - High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels. | 06-30-2016 |
20160250639 | METHOD AND SYSTEMS FOR MICROFLUIDIC LOGIC DEVICES | 09-01-2016 |
20160250640 | INTEGRATED APPARATUS FOR PERFORMING NUCLEIC ACID EXTRACTION AND DIAGNOSTIC TESTING ON MULTIPLE BIOLOGICAL SAMPLES | 09-01-2016 |
20180021774 | Direct Bond Transfer Layers for Manufacturable Sealing of Microfluidic Chips | 01-25-2018 |
20190143326 | MICROFLUIDIC NEUTROPHIL ASSAYS AND SYSTEMS FOR DISEASE DETECTION | 05-16-2019 |
20220134333 | SYSTEM AND METHOD FOR PATTERNING FLOW CELL SUBSTRATES - A method for patterning flow cell substrates using photo-initiated chemical reactions that includes fabricating a planar waveguide flow cell by forming a layer of light coupling gratings on a glass substrate layer; depositing a core layer on the layer of light coupling gratings; depositing a cladding layer on the core layer; and forming nanowells in the cladding layer; silanizing the cladding layer; coating the silanized cladding layer and nanowells with a first group of reactants; introducing a second group of reactants into the nanowells, wherein the second group of reactants includes a target reactant and a light-sensitive photoinitiator system; coupling a light source to the light coupling gratings and directing light internally within the planar waveguide flow cell for photo-initiating a chemical reaction between the first and second groups of reactants, wherein the photo-initiated chemical reaction covalently binds the target reactant to only the bottom portion of each nanowell. | 05-05-2022 |
20220134334 | ON-CHIP LOCALIZATION MICROSCOPY - An analysis substrate comprises: a localization layer to be provided with a sample comprising a nucleotide provided with a fluorescent dye; and a sensor layer comprising an array of sensor pixels, the localization layer being on-chip relative to the sensor layer, one or more of the array of sensor pixels to receive a propagation of fluorescence from the fluorescent dye. | 05-05-2022 |
20220134335 | Device for Analysing a Biological Sample - A fluidic network for carrying out, in parallel, a plurality of analyses of biological samples is disclosed. The network has a flow cell array with a plurality of reaction chambers. The reaction chambers each have a first channel connection and a second channel connection. The first channel connections are connected to a first supply channel and the second channel connections are connected to a second supply channel. The first supply channel and the second channel connection are interconnected by a circulation line. At least one component is connected to the circulation line so that component test reagents can be introduced into the reaction chambers of the flow cell array. | 05-05-2022 |
20220134338 | DIAGNOSTIC ASSAY SYSTEM WITH REPLACEABLE PROCESSING MODULES AND REMOTE MONITORING - A biological sample processing apparatus having an enclosure and a plurality of sample processing modules held within an enclosure with a tiltable graphical user interface screen. In one aspect, the individual modules that are readily removable for repair, replacement or upgrade. Each module is configured to be independently operable and readily inserted into the enclosure for connection with a processing unit of the enclosure. Each module can include quick-release mechanisms so that the module can be readily removed and replaced manually or with minimal tools through the front of the enclosure without requiring substantial or total disassembly of the module or entire enclosure. In another aspect, the user interface screen can display identifying information, such as a barcode, that can be scanned by a user's portable device so as to monitor the progress of an assay remotely. | 05-05-2022 |