Entries |
Document | Title | Date |
20100267640 | Method of Attenuating Neurogenic Swelling or Neurogenic Inflammation - The present invention provides a method of attenuating the formation or reducing the severity of neurogenic swelling and/or neurogenic inflammation in the tissue of a patient via applying a composition comprising a hydrophilic foam substrate and a polymeric hydrophilic agent to a portion of the surface of the skin in an amount and at a location sufficient to attenuate formation of or reduce the severity of neurogenic swelling and/or neurogenic inflammation. | 10-21-2010 |
20100331257 | PREPARATION OF TERMINALLY-STERILIZED COLLAGEN THAT IS SOLUBLE AT NEUTRAL PH - Terminally sterilized collagen that is soluble at a neutral pH is useful for medical uses. The invention also relates to the method for preparing such terminally sterilized collagen. | 12-30-2010 |
20110028400 | SULFATED UNSATURATED DISACCHARIDIC CHONDROITIN SULFATE IN CONNECTIVE TISSUE PROTECTION AND REPAIR - The present invention generally relates to the protection and repair of connective tissues. In particular, the present invention relates to the use of chondroitin sulfates and its derivatives in connective tissue protection and repair. The present inventors have found that unsaturated disaccharidic chondroitin sulfate can be used for the preparation of a composition to develop, protect and/or repair connective tissues. This allows it for example to treat or prevent osteoarthritis or rheumatoid arthritis, and/or the symptoms thereof as well as to treat or prevent signs of skin ageing such as the appearance of wrinkles effectively. | 02-03-2011 |
20110034392 | Hyaluronic Acid and Chondroitin Sulfate Based Hydrolyzed Collagen Type II and Method of Making Same - Hydrolyzed collagen type II powder compositions for inducing cartilage formation in an individual, method of preparing the compositions and use of the compositions in treating connective tissue disorder, replenishing skin viscoelasticity. The compositions are administered through an orally ingestible delivery medium for absorption into the gastrointestinal tract. The compositions are administered through a topical delivery medium for absorption into a dermis of the individual. | 02-10-2011 |
20110053854 | TREATMENT OF MUSCULAR DYSTROPHIES AND RELATED DISORDERS - The invention provides, among other aspects, compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; diseases or conditions associated with an abnormal level or activity of collagen VI; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); and disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. | 03-03-2011 |
20110053855 | Ex vivo cell stimulation - Provided herein is are methods for evaluating the biological activity and/or therapeutic potential of a glucan, comprising in one embodiment: co-culturing a first population of cells with a second population of cells, wherein the first population comprises cells capable of being stimulated by said glucan to produce and/or secrete cytokines and growth factors, and the second population comprises collagen-producing cells; contacting said co-cultured cells with the glucan and incubating for a period of time sufficient to induce the production of collagen from the collagen-producing cells; and determining the level of production of collagen from said collagen-producing cells, wherein the level of production of collagen is indicative of the biological activity and/or therapeutic potential of the glucan. | 03-03-2011 |
20110086802 | METHODS TO INCREASE PERMEABILITY OF CORNEAL EPITHELIUM AND DESTABILIZE STROMAL COLLAGEN FIBRIL NETWORK - Methods of increasing the permeability of corneal epithelium to facilitate the diffusion of agents into the collagen fibrillar network of the stroma are provided. Used in combination, these methods open the epithelium to facilitate diffusion of stabilization molecules into the stroma and dissociate bridging molecules from stromal collagen fibers, thereby priming the collagen fibrillar network for restabilization by stabilization molecules. These methods can be used to increase the effectiveness and longevity of non-invasive corneal reshaping, such as orthokeratology, for correcting myopia, hyperopia and astigmatism. | 04-14-2011 |
20110092431 | SKIN AGING-INHIBITING PEPTIDE - The present invention provides a peptide and a composition which are suitable for oral ingestion, and which have a skin aging-inhibiting activity, a collagen-production promoting activity, an epidermal turnover promoting activity, and a cutaneous cell-proliferating effect. The present invention also provides a medicament and a functional food which have a skin aging-inhibiting activity, a collagen-production promoting activity, and a cutaneous cell-proliferation promoting activity. The present invention provides a composition including at least one peptide of Asn-Ile-Pro-Pro-Leu, Ile-Pro-Pro-Leu, Ile-Pro-Pro, Pro-Val-Val-Val-Pro-Pro, Val-Pro-Pro-Phe, Val-Pro-Pro, Phe-Pro-Pro-Gln, and Leu-Pro-Pro-Thr. | 04-21-2011 |
20110092432 | VASCULAR AGING INHIBITOR AND ANTI-AGING FORMULATION - A vascular aging inhibitor includes a low molecular weight collagen derived from fish skin as an essential component, wherein the weight average molecular weight of the low molecular weight collagen derived from fish skin is approximately 3,000. | 04-21-2011 |
20110144027 | PHARMACEUTICAL COMPOSITIONS FOR PROMOTING WOUND HEALING - The present invention relates to pharmaceutical compositions and methods for promoting wound healing. The invention also relates to methods of making pharmaceutical compositions disclosed herein. Pharmaceutical compositions are disclosed comprising an effective amount of a 2-alkoxyadenosine or 2-aralkoxyadenosine, about 10% to about 70% w/w propylene glycol and a thickening agent. | 06-16-2011 |
20110152196 | ISOLATED EXTRACELLULAR MATRIX MATERIAL INCLUDING SUBSEROUS FASCIA - Described are purified extracellular matrix materials isolated from the abdominal wall of animals and including the subserous fascia layer of the abdominal wall. Such medical materials can find use in treating damaged tissue and in certain aspects in providing tissue support for the repair of hernias. Related methods of manufacture and use are also described. | 06-23-2011 |
20110160137 | COMPOSITION CONTAINING COLLAGEN PEPTIDE FOR IMPROVING SKIN CARE - The present invention relates to an oral composition for improving the beauty of the skin, which exhibits the effects of reducing skin wrinkles and inhibiting wrinkle formation. The composition contains a collagen peptide and at least one selected from the group consisting of elastin protein, hyaluronic acid and vitamin C. Particularly, the composition contains the collagen peptide, the elastin protein, hyaluronic acid and vitamin C at the optimum ratio, and when it is taken into the human body, it has no side effect, maximizes the biosynthesis of collagen in the skin dermal layer, shows excellent in vivo retention rate, and exhibits the effects of inhibiting skin wrinkle formation, maintaining or improving skin elasticity and moisturizing the skin. Thus, the composition will be useful as a health functional food for improving the beauty of the skin and preventing skin aging. | 06-30-2011 |
20110207671 | METHOD FOR PRODUCING DOUBLE-CROSSLINKED COLLAGEN - The present invention relates to double-crosslinked collagen materials, methods for preparing double-crosslinked collagen materials, and methods of using double-crosslinked | 08-25-2011 |
20110212894 | DECELLULARIZATION METHOD FOR SCAFFOLDLESS TISSUE ENGINEERED ARTICULAR CARTILAGE OR NATIVE CARTILAGE TISSUE - Methods for fabricating a tissue-engineered construct comprising: providing a tissue-engineered construct, wherein the tissue-engineered construct is derived from a xenogenic source; and decellularizing the tissue-engineered construct. | 09-01-2011 |
20110218151 | SUBSTANCES FOR PROMOTING HEALTHY JOINT FUNCTION COMPRISING OMEGA-3 POLYUNSATURATED FATTY ACIDS OR DRIVATIVES THEREOF, UNDENATURED TYPE II COLLAGEN AND, OPTIONALLY, GLUCOSAMINE SULFATE - Medicaments and therapeutic compositions contain (1) at least one omega-3 polyunsaturated fatty acid, or at least one pharmaceutically acceptable omega-3 polyunsaturated fatty acid derivative or mixtures thereof, (2) undenatured Type II collagen and, optionally, (3) glucosamine sulfate. One source of the fatty acids or derivatives thereof is fish oil. The compositions are useful for promoting joint health in a subject. | 09-08-2011 |
20110288026 | Electroprocessed Collagen and Tissue Engineering - The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs. | 11-24-2011 |
20110306555 | BIOLOGIC REPLACEMENT FOR FIBRIN CLOT - The invention provides composition and methods for repairing a ruptured anterior cruciate ligament. | 12-15-2011 |
20120010146 | COMPOSITE CONTAINING COLLAGEN AND ELASTIN AS A DERMAL EXPANDER AND TISSUE FILLER - An injectable composition having dermal filling and tissue expanding activity comprises (1) a quantity of elastin sufficient to bring about dermal filling and tissue expansion when injected into a subject in need of dermal filling and tissue expansion, and (2) a pharmaceutically acceptable carrier. The composition can further comprise collagen, in other alternatives, the composition can further comprise hyaluronic acid, and one or more of the elastin, the collagen, and the hyaluronic acid, if present can be cross-linked, either intramolecularly or intermolecularly. The elastin, however, is the primary filler, even if collagen or hyaluronic acid are included in the composition | 01-12-2012 |
20120058948 | Collagen peptides as immune modulators - The invention relates to collagen peptides, as well as related methods. The invention also relates to methods and products for modulating cytokine production and/or inflammation. | 03-08-2012 |
20120142598 | EDIBLE COMPOSITIONS FOR PREVENTING HAIR LOSS - The present invention provides compositions comprising hydrolyzed gelatin or a mixture of hydrolyzed gelatin and gelatin, and the same compositions for use in methods comprising administering a low dose of the compositions useful in prophylaxis and treatment of hair loss in humans and shedding in animals. The compositions provide a palatable, malleable and well-tolerated product. | 06-07-2012 |
20120142599 | EXTRACT OF R. MIEHEI - Topical compositions comprising extracts of | 06-07-2012 |
20120165264 | Degradation-Stabilised, Biocompatible Collagen Matrices - The present invention relates to degradation-stabilised, biocompatible collagen matrices which are distinguished in particular by the fact that they contain soluble collagen and peptide constituents, to processes for the preparation of such collagen matrices, which processes include in particular chemical crosslinking with an epoxy-functional crosslinking agent, and to the use of the collagen matrices according to the invention as a cosmetic or pharmaceutical agent, in particular for topical use, and as a wound treatment agent, as an implant or as a haemostatic agent in humans or animals, and as a scaffold for cell population in the biotechnology, basic research and tissue engineering field. | 06-28-2012 |
20120238502 | ANTI-FIBROTIC HYDROGEL COMPOSITIONS - A cross linked recombinant gelatin composition for the controlled release of a cellular adhesion inhibitory agent. | 09-20-2012 |
20120264695 | NON-POROUS FILM FOR CULTURING CELLS - The invention relates to collagenous polypeptide films on which cells are cultivated. In particular the invention relates to such films that are used to treat wounds such as severe burns or physical or chemical injury. The invention also related to methods for producing such films. | 10-18-2012 |
20120283192 | METHOD OF TREATING CONDITIONS ASSOCIATED WITH AIRWAY TISSUE REMODELING - The invention provides a method for improving airway conductance in a subject in need thereof, the method comprising administering to the subject an effective amount of one or more of tumstatin; a derivative, variant or homologue thereof; a polynucleotide encoding tumstatin or a derivative, variant or homologue thereof; or an agent capable of increasing the expression or production of tumstatin. | 11-08-2012 |
20130005660 | Plasma Activation of Biological Materials for Surface Modification - Disclosed in certain embodiments is a composition comprising a biological material activated by oxygen plasma and a ligand bound to a surface of the biological material. | 01-03-2013 |
20130005661 | PHARMACEUTICAL COMPOSITIONS - The present invention discloses a pharmaceutical polymer and a method for quenching free radicals. Said pharmaceutical polymer comprises a glycopeptides and an aminothiol moiety which covalently bonds together. The disclosed pharmaceutical polymer and method can be applied before or after the occurrence of radiation exposure. | 01-03-2013 |
20130012446 | COMPOSITIONS AND MANUFACTURE OF MAMMALIAN STEM CELL-BASED COSMETICS - Methods of manufacturing collagen and other extracellular matrix components from SCCs are disclosed. The extracellular matrix components are useful in cosmetic applications, and can be manufactured free of immunogenic concerns and contaminants while controlling for other factors that commonly impact product quality and usefulness. | 01-10-2013 |
20130029914 | SEBUM SECRETION-BLOCKING COMPOSITION, AND FOOD OR BEVERAGE CONTAINING SAME - An object is to provide a sebum secretion inhibiting composition and a food or drink product using the same. The present inventors have conducted extensive studies and consequently found that the sebum secretion is inhibited by orally ingesting a collagen peptide, which is hydrolyzed collagen, and provide an oral sebum secretion inhibiting composition comprising a collagen hydrolysate and a food or drink product containing the composition. | 01-31-2013 |
20130029915 | CROSSLINKED HUMAN OR ANIMAL TISSUE PRODUCTS AND THEIR METHODS OF MANUFACTURE AND USE - Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation. | 01-31-2013 |
20130040891 | CHEMICALLY MODIFIED WATER-SOLUBLE ELASTIN, MIXED GEL OF CHEMICALLY MODIFIED WATER-SOLUBLE ELASTIN AND COLLAGEN, AND PROCESS FOR PRODUCING SAME - A chemically modified water-soluble elastin that is obtained by subjecting to N-acylating some or all of the primary amines and secondary amines contained in the molecule of a high molecular weight water-soluble elastin and coupling some or all of the carboxyl groups contained in the molecule with the amino group of an amino acid alkyl ester. | 02-14-2013 |
20130045923 | COLLAGENOUS MATERIAL - The present invention relates to a collagenous material and to a process for the manufacture thereof. The process is for the manufacture of a collagenous material from a plurality of collagen particles, wherein said collagen particles are derived from a natural tissue material and are substantially free of non-fibrous tissue proteins, cellular elements and lipids or lipid residues, and wherein said collagen particles comprise fragments of collagen fibres displaying original collagen fibre architecture and molecular ultrastracture of said natural tissue material, said process comprising steps of treating the collagen particles with an aqueous acid solution to swell the collagen particles; and collectively dehydrating the swollen collagen particles. The collagenous material may be used, for example, in wound care. | 02-21-2013 |
20130072436 | PROCESS FOR MANUFACTURING COLLAGEN AND TRACE ELEMENTS FROM SEA WATER - The process for manufacturing collagen and trace elements from sea water consists of various steps which are raw material preparation, resting of raw material, preliminary filtration to remove heavy metals, deodorize and purity remaining impurities, spraying of water, separation of heavy metals, collagen and trace elements from water and separation of collagen and trace elements. The process according to this invention, apart from sea water, can be applied to other type of salt water by adjusting the salinity and density of the water to an optimal value. The process according to this invention yields clean and purified collagen which is easily absorbed by human body and contains numerous types of trace elements. | 03-21-2013 |
20130079285 | SOLUBILIZED COLLAGEN FIBERS AND METHOD FOR PRODUCING THE SAME - Provided are novel solubilized collagen fibers with which solubilized collagen can be obtained by instantaneous uniform dissolution in water at the time of use. The solubilized collagen fibers are formed from a solubilized collagen solid content of 66 to 87 wt %, buffer salt content of 2 to 6 wt %, water content of 10 to 22 wt %, and a residual hydrophilic organic solvent content of a trace amount of up to 6 wt % (totaling 100 wt %). The solubilized collagen fibers have an average fineness of 3 to 10 dtx, an isoionic point of 4.5 to 5.0, a water content of 10 to 22 wt %, and residual hydrophilic organic solvent content of a trace amount of up to 6.0 wt %. The solubilized collagen fibers are present uniformly in the direction of fiber length. The buffer salt is selected from sodium citrate, sodium lactate, and sodium phosphate. | 03-28-2013 |
20130096064 | FLOWABLE FORMULATIONS FOR TISSUE REPAIR AND REGENERATION - The present invention relates generally to flowable tropocollagen formulations and uses of such formulations for promoting healing and tissue repair and/or regeneration in wounds induced by, for example, trauma or injury, a disease state, bed sores or other pressure ulcers, or surgery. | 04-18-2013 |
20130116188 | IMPLANTABLE HYALURONIC ACID/COLLAGEN COMPOSITIONS - Hyaluronic acid and collagen may be crosslinked in aqueous solution as described herein. The crosslinked macromolecular matrices obtained in this process may be used as a hydrogel for implants and fillers for human aesthetic and therapeutic products. | 05-09-2013 |
20130116189 | RETINOL-MODIFIED COLLAGEN, METHOD FOR PRODUCING SAME, AND EXTERNAL COMPOSITION FOR SKIN CONTAINING SAME - Disclosed is a compound which exhibits a higher effect of preventing wrinkle formation, a higher effect of improving wrinkles, a higher effect of making the skin beautiful, and a higher effect of improving skin quality than conventional retinol and retinol derivatives in a sustained manner. Further disclosed are a method for producing the same, and an external composition for the skin and a sheet-shaped cosmetic each containing the same as an active ingredient. More specifically disclosed are retinol-modified collagen in which a dicarboxylic acid is attached to at least one hydroxyl group of collagen and retinol is attached to a carboxyl group of at least one attached dicarboxylic acid, a method for producing the same, and an external composition for the skin and a sheet-shaped cosmetic each containing the same as an active ingredient. | 05-09-2013 |
20130116190 | HYALURONIC ACID-COLLAGEN MATRICES FOR TISSUE ENGINEERING - Hydrogels comprising a macromolecular matrix including a crosslinked combination of hyaluronic acid and collagen, are provided for tissue engineering applications. | 05-09-2013 |
20130137640 | Skin Collagen Enhancing Agent - A composition includes a food ingredient or nutrient with safety and experience having been eaten for a long time and that shows a collagen enhancing activity. The food ingredient or nutrient of the composition includes a skin collagen enhancing agent that includes menaquinone-7 as an active ingredient. The composition including skin collagen enhancing agent can be administered percutaneously or orally as a drug, a cosmetic, or a supplement. | 05-30-2013 |
20130150305 | Method for Promoting Wound Healing - The present invention discloses a method for treating wounds and for accelerating the healing of wounds by administering an effective amount of a pharmaceutical composition containing type VII collagen protein, mini-C7 protein, variants thereof or any combinations thereof. The pharmaceutical composition may be administered through a variety of routes including intravenous injection, topical application, or oral ingestion. The method may further include administering a genetically modified fibroblast capable of expressing type VII collagen protein, mini-C7 protein, variants thereof or small growth factors to achieve synergistic healing effect. | 06-13-2013 |
20130157956 | BIOCOMPATIBLE COMPOSITIONS FOR TISSUE AUGMENTATION - A crosslinked gelatin hydrogel composition for tissue augmentation. | 06-20-2013 |
20130165384 | Decellularized small particle tissue - A process for producing a decellularized small particle tissue which involves selecting an appropriate tissue starting material from which a decellularized small particle tissue is desired to be prepared, treating the tissue with a decellularizing agent at an acid pH to remove at least a portion of the cellular material therefrom and to yield a product comprising a liquid component and a solid component, subjecting the liquid component and the solid component to a plurality of filters, F | 06-27-2013 |
20130178426 | THERAPEUTIC AGENT FOR PULMONARY EMPHYSEMA - The invention has as its object the provision of a medicine capable of reducing a volume of emphysema-suffering pulmonary alveoli or alveolar sacs by means of a respiratory region volume inhibitor containing a coating film formation as a main component and capable of forming a coating film in a respiratory region, characterized by being used in such a way that the coating film-forming component is administered to an emphysema-suffering pulmonary alveolar parenchyma in a human-respiratory region in an amount of 0.004 to 200 g/application, preferably 0.07 to 20 g/application and more preferably 0.5 to 5 g/application on each occasion. | 07-11-2013 |
20130190245 | Light Activated Composite Tissue Adhesives - A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions caused by bacteria and as the consequence of surgical procedures. These composites have also been found to be strong tissue adhesives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound is eradicated resulting in a sterile wound. In other examples, the composite film may instead contain lumichrome or lumiflavin. | 07-25-2013 |
20130190246 | COLLAGEN-BINDING SYNTHETIC PEPTIDOGLYCANS FOR USE IN VASCULAR INTERVENTION - This invention relates to collagen-binding synthetic peptidoglycans. More particularly, this invention relates to collagen-binding synthetic peptidoglycans for use in vascular intervention procedures. The invention also relates to kits comprising such collagen-binding synthetic peptidoglycans and catheters or stents. | 07-25-2013 |
20130217631 | COLLAGEN MIXTURE AND METHOD OF MAKING THE SAME - A collagen mixture having a portion of unhydrolyzed eggshell membrane collagen and Avian collagen. | 08-22-2013 |
20130225497 | SKIN COLLAGEN PRODUCTION-PROMOTING AGENT - A skin collagen production-promoting agent includes a milk protein fraction having following properties (a) to (c) as an active ingredient: (a) being derived from milk, (b) containing proteins having a molecular weight determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of 6000 to 150,000 daltons, and (c) containing 12 to 14 wt % of basic amino acids with respect to the constituent amino acid composition, and having a basic amino acid/acidic amino acid ratio of 0.5 to 0.7. | 08-29-2013 |
20130231288 | HUMAN PLACENTAL COLLAGEN COMPOSITIONS, AND METHODS OF MAKING AND USING THE SAME - The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal. | 09-05-2013 |
20130237485 | Methods and Agents for Enhancing Wound Healing - This invention discloses a method of inducing expression of full-length collagen 7 in cells that contain nonsense mutations in the COL7A1 gene by treating the cell with an aminoglycoside such as G418, gentamicin, and paromomycin. Also provided is a method of treating DEB due to nonsense mutation in the COL7A1 gene by administering a composition containing an effective amount of an aminoglycoside. Also provided is a novel composition useful to treating conditions due to nonsense mutation in the COL7A1 gene, containing an aminoglycoside, a C7, a min-C7 or both; and a pharmaceutically acceptable carrier. | 09-12-2013 |
20130237486 | COLLAGEN - The present invention relates to a trimeric fusion protein comprising three polypeptide chains, wherein each polypeptide chain comprises a eukaryotic collagen or collagen-like domain and a prokaryotic or viral trimerisation domain (PVTD). Also provided is a fusion polypeptide comprising a eukaryotic collagen or collagen-like domain and a PVTD. A suitable PVTD of a fusion polypeptide or protein of the invention is preferably derived from a collagen-like protein sequence found in the genome of the | 09-12-2013 |
20130244943 | HYALURONIC ACID-COLLAGEN MATRICES FOR DERMAL FILLING AND VOLUMIZING APPLICATIONS - Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen. | 09-19-2013 |
20130252899 | COLLAGEN HYDROLYSATE FOR USE TO IMPROVE THE HEALTH OF HUMAN SKIN, HAIR AND/OR NAILS - The invention relates to a collagen hydrolysate for use to improve the health of human skin, hair and/or nails, at least 90% by weight of the collagen hydrolysate having a molecular weight of less than 3,500 Da and the collagen hydrolysate comprising at least four characteristic peptides with a molecular weight between 600 and 1,200 Da. | 09-26-2013 |
20130252900 | MICROSPHERES USEFUL FOR THERAPEUTIC VASCULAR EMBOLIZATION - Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof. | 09-26-2013 |
20130288973 | Decellularized small particle tissue - A process for producing a decellularized small particle tissue which involves selecting an appropriate tissue starting material from which a decellularized small particle tissue is desired to be prepared, treating the tissue with a decellularizing agent at an acid pH to remove at least a portion of the cellular material therefrom and to yield a product comprising a liquid component and a solid component, subjecting the liquid component and the solid component to a plurality of filters, F | 10-31-2013 |
20130310322 | ISOLATED EXTRACELLULAR MATRIX MATERIAL INCLUDING SUBSEROUS FASCIA - Described are purified extracellular matrix materials isolated from the abdominal wall of animals and including the subserous fascia layer of the abdominal wall. Such medical materials can find use in treating damaged tissue and in certain aspects in providing tissue support for the repair of hernias. Related methods of manufacture and use are also described. | 11-21-2013 |
20130345140 | Basement Membrane Compositions and Applications Thereof - The invention relates to cell support compositions comprising a basement membrane extract isolated from cardiac or smooth muscle. The invention also relates to methods of using the cell support compositions for supporting cellular functions. | 12-26-2013 |
20140005115 | LIPID CONJUGATES IN THE TREATMENT OF BRONCHITIS | 01-02-2014 |
20140011743 | HUMAN PLACENTAL COLLAGEN COMPOSITIONS, AND METHODS OF MAKING AND USING THE SAME - The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal. | 01-09-2014 |
20140031295 | Recombinant C7 and Methods of Use - The present disclosure provides methods of treating epidermolysis bullosa, and/or preventing, preventing the progression of, or delaying the onset of one or more symptom associated with scarring, e.g., of blisters, in subjects with epidermolysis bullosa through chronic systemic administration of collagen 7. | 01-30-2014 |
20140045761 | WOUND PROGNOSIS - Methods and devices for determining the healing status of wounds, in particular of chronic wounds are provided. Also provided are kits comprising the diagnostic devices, and methods of wound diagnosis and treatment using the diagnostic devices and methods. A diagnostic apparatus (device) for monitoring wounds that exude a wound fluid and determining whether said wounds would be responsive to treatment with wound therapy such as oxidized cellulose therapy is also provided along with kits comprising the diagnostic apparatus and a wound dressing. Furthermore, methods of prognosing and treating wounds that exude a wound fluid are also provided. | 02-13-2014 |
20140066379 | RECOMBINANT VECTOR, TRANSGENIC FISH EGG USING THE SAME AND BIOMATERIAL USING THE SAME - A recombinant vector, transgenic fish egg using the same and biomaterial using the same are applied to provide a transgenic fish that secreting recombinant human procollagens or collagens, and further to provide the biomaterial having the recombinant human procollagens or collagens and extract the recombinant human procollagens or collagens from the part(s), having the recombinant human procollagens or collagens, of the transgenic fish. | 03-06-2014 |
20140073575 | COLLAGEN HYDROXYLASES - Prolyl and lysyl hydroxylases isolated from Mimivirus are described. These are able to hydroxylate collagen. Isolated nucleic acids coding for the mentioned hydroxylases are incorporated into suitable vectors and used to express these hydroxylases in host cells, e.g. | 03-13-2014 |
20140107035 | METHODS OF TREATING FIBROSING DISEASES BY INDUCTION OF IMMUNE TOLERANCE - The present invention has demonstrated for the first time that orally administered type I collagen (CI) induced tolerance to CI in patients suffering from systemic sclerosis (SSc) and ameliorated clinical manifestations of the disease. Accordingly, the present invention provides methods of treating a fibrosing disease by oral administration of a tissue protein, for example, collagen, derived from the tissue undergoing fibrosis. | 04-17-2014 |
20140107036 | Production and Delivery of a Stable Collagen - Improved methods are provided for the recombinant synthesis of collagen, particularly collagen VII, in host cell, and for therapeutic delivery of the same. The recombinant collagen is produced in a host cell that has increased levels of prolyl-4-hydroxylase, relative to basal cell levels. The collagen produced by the methods of the invention has increased numbers of modified proline residues, relative to a recombinant collagen produced in a host cell having basal levels of prolyl-4-hydroxylase. The increased proline modification provides for a collagen having increased stability, including increased in vivo stability. | 04-17-2014 |
20140142041 | Cross-linked collagen comprising metallic anticancer agents - The disclosure describes collagen constructs comprising anticancer agents, preferably, platinum, and related methods. | 05-22-2014 |
20140179612 | Transferrin-Tumstatin Fusion Protein and Methods For Producing and Using the Same - The present invention provides recombinant proteins comprising transferrin that is linked to tumstatin or other antiangiogenic protein and methods for producing and using the same. The present invention also provides an expression system, a plasmid, and a cell that is capable of expressing such recombinant proteins and methods for producing and using the same. | 06-26-2014 |
20140213525 | CORNEAL STIFFENING FOR TREATING ASTIGMATISM - Methods are provided for treating astigmatism in an eye of a patient. An axis of greater curvature of the eye is determined. A stiffening process is applied to a cornea of the eye in a pattern defined from the axis of greater curvature of the eye. | 07-31-2014 |
20140288003 | INHIBITION OF COLLAGEN SYNTHESIS - Therapies and compositions for reducing collagen synthesis in mammalian cells and tissues wherein the targets are scleraxis, scleraxis-binding sites, receptor-regulated Smads, and/or binding sites for receptor-regulated Smads whereby synergistic interactions between scleraxis proteins and receptor-regulated Smads are reduced, inhibited, interfered with, stopped, and/or prevented thereby reducing, inhibiting and/or interfering with the activation of collagen 1α2 promoter thereby inhibiting collagen production in mammalian cells and tissues. Alternatively, the therapies and compositions may reduce, inhibit, interfere with, stop, and/or prevent binding of the collagen 1α2 promoter to DNA thereby inhibiting expression of the collagen 1α2 gene in mammalian cells and tissues. | 09-25-2014 |
20140315819 | ACTIVE SMALL-MOLECULE DONKEY-HIDE GELATIN MIXTURE AND PREPARATION METHOD AND APPLICATION THEREOF - An active small-molecule donkey-hide gelatin mixture and a preparation method and application thereof. The active small-molecule donkey-hide gelatin mixture is prepared by using the compound protease comprising the proline protease to perform the enzymatic hydrolysis on the donkey-hide gelatin juice to which no auxiliary material is added. For the active small-molecule donkey-hide gelatin mixture, the weight-average molecular weight ranges from 580 Da to 1300 Da, the peptide segments are distributed from 200 Da to 3000 Da, the dissolution rate in cold water is high, and the content of free amino acid is low; the active small-molecule donkey-hide gelatin mixture may be used for manufacturing small-molecule peptide food and health care food of donkey-hide gelatin. | 10-23-2014 |
20140329756 | TEMPERATURE-RELEASE CATALYST FOR CROSS-LINKING HALYURONIC ACID DURING INJECTION - Systems and methods for cosmetic augmentation by forming a biocompatible cross-linked polymer having a multi-phase mixture with a temperature activated catalyst; injecting the mixture into a patient as a homogeneous fluid; activating the catalyst to cross-link the polymer at a predetermined temperature in a patient; and augmenting soft tissue with the biocompatible cross-linked polymer. | 11-06-2014 |
20140336125 | METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY - A method for improving bioactivity and/or biodegradation time of a collagen surgical implant and collagen surgical implants having such improved properties. A gas-cluster ion-beam (GCIB) is formed in a reduced-pressure chamber, a collagen surgical implant is introduced into the reduced-pressure chamber, and at least a first portion of the surface of said collagen surgical implant is irradiated with a GCIB-derived beam. | 11-13-2014 |
20140357568 | Method of Increasing Muscle Mass and Strength and Compositions Therefor - A method of increasing muscle mass and strength in mammals by orally administering a therapeutically effective amount of phosphatidic acid. The phosphatidic acid is preferably administered as a plurality of doses per day with at least one dose being administered during the anabolic window following exercise. Preferably, the method further includes the cotemporaneous administration of a therapeutically effective amount of creatine, optionally as phosphatidylcreatine. In addition or in the alternative, the method further includes the cotemporaneous administration of a therapeutically effective amount of leucine, optionally as phosphatidylleucine. | 12-04-2014 |
20150011476 | MODIFIED COLLAGEN - The present invention relates to a modified collagen obtainable by providing isolated collagen; freezing the isolated collagen; dehydrating the frozen collagen; and maturing the dehydrated collagen. Also disclosed are methods of preparing the modified collagen and uses thereof. | 01-08-2015 |
20150018280 | FOAMED BIOCOMPATIBLE MATERIALS FOR TISSUE REPAIR - A foamed biocompatible material for use in tissue repair and a kit for producing same. The kit includes a container having a valve and an inlet, and a tissue-repair composition containing a biocompatible material and a liquid carrier, in which the composition is placed in the inlet of the container and the inside of container has a pressure lower than that of the outside so that, upon opening the valve, the composition is forced into the container by the pressure difference to form a foam inside the container. Also disclosed is a method of preparing a foamed biocompatible material for tissue repair. | 01-15-2015 |
20150038423 | DELIVERY OF THERAPEUTIC AGENTS BY A COLLAGEN BINDING PROTEIN - Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided. | 02-05-2015 |
20150038424 | FORMULATIONS AND KITS FOR FORMING BIOADHESIVE MATRICES - A bioadhesive formulation, comprising gelatin, alginate and a coupling agent, capable of forming a bioadhesive matrix, which is characterized by rapid curing, optimal viscosity, high bonding strength, flexibility, biocompatibility and biodegradability, is disclosed. Further disclosed is such a bioadhesive formulation which further comprises a bioactive agent, and a drug-eluting bioadhesive matrix formed therefrom, the bioadhesive matrix being capable of delivering the bioactive agent to a bodily site. Methods utilizing the bioadhesive formulations and matrices in various biological and medical procedures are also disclosed. | 02-05-2015 |
20150038425 | COLLAGEN-BINDING SYNTHETIC PEPTIDOGLYCANS FOR USE IN VASCULAR INTERVENTION - This invention relates to collagen-binding synthetic peptidoglycans. More particularly, this invention relates to collagen-binding synthetic peptidoglycans for use in vascular intervention procedures. The invention also relates to kits comprising such collagen—binding synthetic peptidoglycans and catheters or stents. | 02-05-2015 |
20150057230 | BIOTIN-CONJUGATED HEXAPEPTIDE-2 DERIVATIVE AND USE THEREOF - The present invention relates to a biotin-conjugated hexapeptide-2 derivative or a pharmaceutically acceptable salt thereof and use thereof. More particularly, the present invention relates to a biotin-conjugated hexapeptide-2 derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, a composition including the same as an active ingredient, and a method for improving wrinkles and inhibiting skin aging using the same. | 02-26-2015 |
20150065429 | CROSSLINKED HUMAN OR ANIMAL TISSUE PRODUCTS AND THEIR METHODS OF MANUFACTURE AND USE - Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation. | 03-05-2015 |
20150065430 | PROCESS FOR MANUFACTURING COLLAGEN AND TRACE ELEMENTS FROM SEA WATER - The process for manufacturing collagen and trace elements from sea water consists of various steps which are raw material preparation, resting of raw material, preliminary filtration to remove heavy metals, deodorize and purity remaining impurities, spraying of water, separation of heavy metals, collagen and trace elements from water and separation of collagen and trace elements. The process according to this invention, apart from sea water, can be applied to other type of salt water by adjusting the salinity and density of the water to an optimal value. The process according to this invention yields clean and purified collagen which is easily absorbed by human body and contains numerous types of trace elements. | 03-05-2015 |
20150105323 | COLLAGEN COMPOSITIONS AND METHODS OF USE - The present disclosure provides an engineered collagen composition comprising collagen, wherein the collagen composition is compressed to form a gradient of at least one physical property. Methods of using and of manufacturing the engineered collagen compositions of the present disclosure are also provided. | 04-16-2015 |
20150119335 | Method of Reducing Exercise-induced Joint Pain in Non-arthritic Mammals - The present invention relates to a method of treating exercise-induced joint pain in arthritis-free mammals by the administration of undenatured Type II collagen. | 04-30-2015 |
20150126453 | METHODS OF REMOVING ALPHA-GALACTOSE - Tissue products lacking a desired percentage of immunogenic epitopes, such as galactose alpha-1,3 galactose epitopes, are provided. Methods of making and using the tissue products are also provided. | 05-07-2015 |
20150126454 | COMPOSITION - A composition that is useful in a skin function improving agent includes at least two of the following: vitamin K, a sapogenol, and a collagen hydrolysate. This composition can be used in a skin function improving agent and is particularly useful in a skin function improving agent for inhibiting transdermal moisture loss and/or for retaining the moisture in the stratum corneum. | 05-07-2015 |
20150306011 | METHODS FOR USING SOY PEPTIDES TO INHIBIT H3 ACETYLATION, REDUCE EXPRESSION OF HMG-COA REDUCTASE AND INCREASE LDL RECEPTOR AND SP1 EXPRESSION IN A MAMMAL - Controlled studies demonstrate that methods using soy related peptides inhibit H3 acetylation, reduce expression of HMG-CoA reductase and increase LDL receptor and Sp1 expression in mammals. The present disclosure is generally directed to using lunasin peptides and/or lunasin peptide derivatives to 1) inhibit H3 acetylation, 2) reduce expression of HMG-CoA reductase, 3) increase LDL receptor expression or 4) increase Sp1 expression in a mammal. In at least one exemplary embodiment of the present disclosure, an effective amount of lunasin peptides or lunasin peptide derivatives and one or more enzyme inhibitors is provided to a mammal to 1) inhibit H3 acetylation, 2) reduce expression of HMG-CoA reductase, 3) increase LDL receptor expression or 4) increase Sp1 expression in a mammal. Additionally, lunasin will protect against, prevent, or reduce: 1) the expression of Matrix metalloproteinase (MMP-1), 2) collagen breakdown, 3) photoaging and 4) the formation of skin wrinkles. | 10-29-2015 |
20150343026 | ADMINISTRATION OF RECOMBINANT COLLAGEN 7 FOR THE TREATMENT OF AGE RELATED DISORDERS - The present disclosure provides methods of treating age related disorders through the administration of collagen 7 or the functional fragment or variant thereof | 12-03-2015 |
20150367030 | COLLAGEN SCAFFOLDS - Methods for preparing and using collagen extracts and collagen scaffolds are provided. Additionally methods and related kits for the repair of articular tissue using the collagen material are provided. | 12-24-2015 |
20160000683 | COMPOSITION FOR MAINTAINING EFFECT OF FILLER - The present invention relates to a composition for maintaining efficacy of a filler for a long period of time by containing collagen as an active ingredient. The composition according to the present invention is useful since the composition can promote the synthesis of hyaluronic acid and inhibit activity of hyaluronidase, thereby maintaining the efficacy of a hyaluronic acid filler for a longer period of time. Therefore, even with less number of times of filler injection, the efficacy of the filler can be maintained and skin irritation can be also reduced. | 01-07-2016 |
20160008508 | TISSUE REPAIR MATERIAL | 01-14-2016 |
20160075764 | OPTIMAL INTERSTRAND BRIDGE FOR COLLAGEN MIMICS - Novel collagen-mimetic peptides are disclosed comprising the formula (Xaa-Yaa-Gly) | 03-17-2016 |
20160075765 | MODIFIED COLLAGEN MOLECULES - This invention relates to modified collagen molecules, in particular, modified collagen-glycosaminoglycan composites. This invention also provides methods for stabilizing collagen molecules and uses of these collagen molecules. | 03-17-2016 |
20160082151 | ANTIBACTERIAL CORNEA REPAIR MATERIAL AND PREPARATION METHOD THEREOF - Disclosed in the invention is a preparation method of an antibacterial cornea repair material, including the following steps: ( | 03-24-2016 |
20160102134 | CROSSLINKED HUMAN OR ANIMAL TISSUE PRODUCTS AND THEIR METHODS OF MANUFACTURE AND USE - Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation. | 04-14-2016 |
20160121013 | FIBRES, A PROCESS FOR PRODUCING SUCH FIBRES AND A WOUND DRESSING INCORPORATING THEM - Multi component fibres for the reduction of the damaging activity of wound exudate components such as protein degrading enzymes and inflammatory mediators in wounds, the fibres comprising: from 10% to 100% by weight of the fibres of pectin and a sacrificial proteinaceous material in a weight ratio of 100:0 to 10:90 pectin to sacrificial proteinaceous material and from 0% to 90% by weight of the fibres of another polysaccharide or a water soluble polymer. | 05-05-2016 |
20160129151 | PROTEIN BASED MATERIALS - Gels and films can be formed from protein dissolved into a benign solvent that comprises alcohol, water, and salt. In one example, the protein can be collagen. In one example, the benign solvent can include a water to alcohol ratio of between ninety-nine-to-one and one-to-ninety-nine by volume, a salt concentration between zero moles per liter and the maximum salt concentration soluble in water, and a protein amount of between near zero percent and about 25 percent by weight as compared to the mixture of water and alcohol. Once the protein is dissolved in the benign solvent, secondary processing steps can be conducted to form protein based bioadhesives, gels, and films with desirable physical properties. Additional process steps can include washings that improve the properties of the protein structures. | 05-12-2016 |
20160168210 | DERIVATIVES OF COLLAGEN-BINDING HAIRPIN PEPTIDES | 06-16-2016 |
20160192686 | COHESIVE LIQUID BOLUS COMPRISING MOLECULES PROVIDING VISCO-ELASTICITY | 07-07-2016 |
20160194378 | PEPTIDES AND USES THEREOF | 07-07-2016 |
20160376326 | MODIFIED BACTERIAL COLLAGEN-LIKE PROTEINS - The present disclosure relates to recombinant or synthetic collagen-like proteins comprising at least one triple-helical domain and wherein the collagen-like protein is modified compared to a native bacterial collagen-like sequence. | 12-29-2016 |
20180021411 | Composition and Method for Improving Sleep Duration and Quality | 01-25-2018 |
20180022789 | GELATIN PARTICLES, METHOD FOR PRODUCING GELATIN PARTICLES, GELATIN-PARTICLECONTAINING CELLS, METHOD FOR PRODUCING GELATIN-PARTICLE-CONTAINING CELLS, AND CELLULAR STRUCTURE | 01-25-2018 |
20190142723 | PRO-PIGMENTING PEPTIDES | 05-16-2019 |