01st week of 2013 patent applcation highlights part 50 |
Patent application number | Title | Published |
20130004907 | METHOD FOR RECOVERING PHOSPHORUS-CONTAINING ALTERNATIVE FUELS IN CEMENT PRODUCTION - In a method for utilizing phosphorus-containing alternative fuels in the cement clinker production, the alternative fuels are thermolyzed using waste heat from the cement clinker production process in a thermolysis reactor different from a rotary kiln of the cement clinker production process, the energy released thereby is supplied to the cement clinker production process, and the thermolysis residues of the phosphorus-containing alternative fuels are discharged from the thermolysis reactor, so that the thermolysis residues of the phosphorus-containing alternative fuels are mixed in the thermolysis reactor with cement kiln bypass products as halogen carriers and the heavy-metal halides produced are drawn off. | 2013-01-03 |
20130004908 | METHOD FOR PRODUCING SILICON AND JIG - The present invention provides a method for producing silicon by at least heating any one of raw materials for silicon production selected from a silica raw material and a carbon material; a silica raw material and silicon carbide; and silicon raw material, in a heating furnace, wherein the method comprises operating at least one of the raw materials for silicon production and a heated product in the heating furnace using a jig, and the jig comprises a non-metallic material portion having a bending strength of 100 MPa or more and a melting point higher than a melting point of silicon, and at least a portion thereof coming into contact with the raw materials for silicon production or the heated product, having a temperature of 1,000° C. or higher, is constituted of the non-metallic material portion. | 2013-01-03 |
20130004909 | Method and Apparatus for Organizing Orthodontic Spacers - Orthodontic spacer and floss set-ups are organized on a set-up holder which is a thin square or rectangular piece of plastic that has a plurality of complementary notches formed across opposite sides. The spacer is positioned more or less in between the notches on the set-up holder and one length of floss is disposed in one notch while the other length of floss is disposed in the complementary notch on the opposite side of the holder. In a supply of two or more spacer set-ups, the set-ups are separated from each other in this manner so that a particular one does not have to be untangled from a jumble of other set-ups. Kits provide pre-made set-ups already organized on a piece of notched plastic. | 2013-01-03 |
20130004910 | SYSTEM FOR POSITIONING ORTHODONTIC COMPONENTS - The invention relates to a system for positioning orthodontic components, more particularly orthodontic brackets, with a base structure made of elastic material, at least one dental cap, which is detachably arranged on the base structure by means of a coupling device and on the underside has a retention fixture corresponding to a tooth for interlocking mounting on the tooth, and at least one bracket holder, which is formed on the at least one dental cap and which is configured to position an orthodontic component on the corresponding tooth at least partially outside the retention fixture when mounting the at least one dental cap. | 2013-01-03 |
20130004911 | METHOD AND APPARATUS FOR FORMING ORTHODONTIC BRACKETS - Proposed is a method and apparatus for forming an orthodontic bracket for use with an orthodontic archwire involving shaping a length of material to form at least two enlarged portions and a base member, the base member being intermediate two arm members and the respective enlarged portions having a thickness that is thicker than the thickness of the base member; bending the length of material at the respective enlarged portions; and coining the respective enlarged portions, such that portions of the arm members define a channel to receive a portion of the orthodontic archwire. | 2013-01-03 |
20130004912 | METHOD AND DEVICE FOR WHITENING TEETH USING SONOCHEMISTRY - Tooth whitening device for whitening teeth using sonochemistry includes a body, and an ultrasonic transducer provided in the body. The ultrasonic transducer is configured for producing ultrasonic waves in the range of 20-100 kHz, and good results have been achieved with ultrasonic waves at a frequency of 40 kHz. There is an ultrasonic horn provided on the body, and the ultrasonic horn is operatively connected with the ultrasonic transducer. A liquid retaining element is provided on the ultrasonic horn, and the liquid retaining element is configured for retaining a liquid tooth whitening composition against a user's teeth. The liquid retaining element may be a sponge or a replaceable pad, such as a foam pad. | 2013-01-03 |
20130004913 | METHOD OF CONTROLLING A DRIVE DEVICE FOR PREPARING A ROOT CANAL, AND ROTATING HANDPIECE FOR ROOT CANAL PREPARATION - A method, and handpiece for performing the method, for controlling a drive device for moving a root canal instrument having a drive shaft and at least one cutting edge for preparing a root canal, and at least one drive motor being operated by a control unit. The root canal instrument is moved in at least one reciprocal movement in a first direction of rotation over a predetermined first angle of rotation and subsequently in a second direction of rotation opposite to the first direction of rotation over a predetermined second angle of rotation. After the at least one reciprocal movement, the root canal instrument is rotated over at least one third angle of rotation. | 2013-01-03 |
20130004914 | DENTAL SEPARATOR APPARATUS AND METHOD - A tooth separator apparatus, according to one embodiment, includes a tong having two arms constructed of a resilient material and having a wedge disposed at each end. An expander member is coupled to the two arms, and a drive shaft is coupled to the expander member. When a user moves or rotates the drive shaft, the expander member is moved into a position which causes the two arms and wedges to separate by a distance sufficient to permit the wedges to be inserted in a patient's mouth and positioned adjacent to two teeth that are to be separated. When the user rotates the drive shaft in the reverse direction, the expander member returns to its original position thereby releasing the separating force on the resilient arms and permitting them and the wedges to move in a closing direction with sufficient force to separate the adjacent teeth. | 2013-01-03 |
20130004915 | System and Method fo Dental Implant and Interface to Abutment For Restoration - A dental assembly for vertical attachment of an implant to a dental abutment for restorative dental procedures is disclosed. The implant includes a cylindrical body having an interior bore formed between a distal end and a proximal end. An abutment interface is formed on the proximal end of the cylindrical body. The interface includes a radial annular interior surface and a flat annular stop surface circumferentially bordering the interior bore. The assembly also includes an abutment including a stem and a post coupled to the stem. An interior bore is formed through the stem and the post. The abutment includes an interface section between the post and the stem. The interface section may include an annular radially curved exterior surface proximate to the post. The radially curved exterior surface and the circular flat surface interfaces with the abutment interface of the dental implant. | 2013-01-03 |
20130004916 | Dental Implant and Abutment Tools - A dental restoration system is disclosed including an implant for attachment to a jaw bone of a patient. The implant includes a cylindrical body having an interior bore formed between a distal end and a proximal end. An abutment includes an interior bore formed through the stem and the post and an interface section interfacing with the abutment interface of the dental implant. An abutment removal insert has a cylindrical end insertable into a groove formed in the interior bore of the abutment. An abutment removal tool screw is insertable within the abutment removal insert. The abutment removal tool screw includes a grip and an opposite end. The opposite end causes the abutment removal insert to contact the abutment. The grip is rotatable to cause the opposite end to create force against the implant to cause the abutment to be detached from the implant. | 2013-01-03 |
20130004917 | AFFIXING AN ARTIFICIAL ELEMENT TO A SURFACE OF DENTINE, ENAMEL, BONE, OR A CORRESPONDING SUBSTITUTE MATERIAL - In accordance with an aspect of the invention, a medical method of affixing an element to a surface of dentine, tooth enamel, bone tissue, or corresponding substitute material is provided, the method comprising the steps of:
| 2013-01-03 |
20130004918 | FLUTED OSTEOTOME AND SURGICAL METHOD FOR USE - A surgical method and tool for expanding an initial osteotomy ( | 2013-01-03 |
20130004919 | METHOD AND A SYSTEM IN THE PREPARATION OF A DENTAL RESTORATION, A MEASURING ELEMENT AND USE THEREOF - A method in the preparation of a dental restoration, in which the dental restoration has an implant unit and a head structure interconnectible with one another, comprises the steps of providing an auxiliary material, providing a computerized head receiving surface representation (A′), manufacturing from the auxiliary material a measuring element having a measuring surface (M) and an implant unit coupling surface (X). The measuring surface (M) is adapted such that it can be captured by an optical measuring device, and the measuring element coupling surface (X) is adapted for mating with the head receiving surface (A). The method may help making the preparation of a dental restoration more time and cost efficient. | 2013-01-03 |
20130004920 | Method for Training a Crew Member of a, in Particular, Military Vehicle - A method and simulator for training a crew member of a vehicle, especially a military vehicle, in the interior of the vehicle. A camera films the vehicle interior and is to be fixed to the head of the crew member. A display device is to be disposed in the field of view of the crew member and is to be fixed to the crew member's head. Via markers in the vehicle interior, the position of a view is defined, and at the position of the view, a detail of a virtual vehicle external environment is overlaid in the display device as a function of the position and viewing direction of the crew member. | 2013-01-03 |
20130004921 | ELECTRONIC APPARATUS INCLUDING PROTRUDING MEMBERS - A dot unit includes an opening formed in a housing and a protruding member disposed in the opening. The protruding member is rotatably supported by a support shaft. The protruding member is rotated by a polymer actuator in a direction that follows a reading direction in which a unit of information is read, and the protruding member is stabilized in a protruding position by contacting a restricting portion. When a finger is moved in the reading direction and contacts the protruding member, the protruding member is likely to be stabilized in the protruding position. | 2013-01-03 |
20130004922 | TACTILE DISPLAY DEVICE - Actuators are disposed between a lower wiring substrate and an upper wiring substrate. The actuators, the lower wiring substrate, and the upper wiring substrate are interposed between a lower frame and an upper frame. The end of each actuator is held between pushing parts of the lower frame and upper frame. The free ends of the actuators move projections upward that are displayed in a tactile display. | 2013-01-03 |
20130004923 | NUTRITION MANAGEMENT METHOD AND APPARATUS FOR A WELLNESS APPLICATION USING DATA FROM A DATA-CAPABLE BAND - Nutrition management techniques and devices are configured for use with a data-capable personal worn or carried device. In one embodiment, a method includes receiving data representing a nutrition profile defining parameters upon which a target score is established. The method includes acquiring data representing acquired parameters associated with nutrition of consumable material components, such as food or drink, and determining data representing values for a first subset of acquired, the values representing a first quantum of nutrition associated with a first subset of consumable materials based on the nutrition profile. The method also includes calculating a nutrition score based on data representing the values, and adjusting the nutrition score based on threshold amounts for one or more of the values. In some embodiments, the method includes causing presentation of a representation a nutrition score as, for example, an indicia of contributions of nutrition on health and wellness. | 2013-01-03 |
20130004924 | SYSTEMS AND METHODS FOR COMPUTER IMPLEMENTED TREATMENT OF BEHAVIORAL DISORDERS - A system and method are provided for treating excessive or problematic computer use. In at least one embodiment, a method is employed to treat excessive or problematic computer use by acquiring information about the unwanted user activity, monitoring user activity for the unwanted behavior, controlling the behavior when it occurs, enabling the user to record self-observations and evaluating the results. This method may employ a computer based system to treat excessive or problematic computer use which includes configuring a user activity monitor with constraints, programmatically enforcing those constraints, reporting the activities monitored and restricted, and enabling a user to input self-observations. Potential constraints include a complete bar on the user activity, as well as, progressively decreasing the amount of time the user may engage in the activity, i.e. titrating the user activity. | 2013-01-03 |
20130004925 | KEY FOB CONTROLLER FOR AN IMPLANTABLE NEUROSTIMULATOR - Devices, systems, and methods incorporate the most-used functions of a electrical stimulator's controller into a small, thin pocket controller that is not only comfortable to carry in a pocket, but can also be attached to a key ring, lanyard, or other such carrying device for ease of daily use. A separate patient controller charger is used to charge and control the implanted medical device. | 2013-01-03 |
20130004926 | System and method for a uterus apron to teach various birthing techniques - A system and method of teaching various birthing techniques using a uterus apron. The uterus apron comprises at least one layer of material that forms a bulbous cavity. An elastic opening near a narrow portion of the bulbous cavity allows a fetal doll to pass through to simulate various birthing techniques. Strap(s) are used to attach the uterus apron tightly to a model. When the uterus apron is attached to a model, various birthing techniques may be simulated and taught. | 2013-01-03 |
20130004927 | CRASH SIMULATION AND CRASH SIMULATION METHOD - A crash simulation system has a parallel carriage ( | 2013-01-03 |
20130004928 | REACTION TRAINING APPARATUS AND METHODS OF USE - The present invention includes a reactive training apparatus and methods of training designed to utilize special physical-preparation means to develop and/or enhance a sport-specific or task-specific motor ability. The reactive training apparatus includes a display which displays target objects and clutter objects. A trainee reacts to these objects in various ways, and these reactions may be recorded and analyzed to improve the trainee's reactions. The present invention may be used to enhance the biomechanical efficiency, reaction time, and accuracy of a trainee. | 2013-01-03 |
20130004929 | EDUCATIONAL SYSTEM AND METHOD FOR CREATING LEARNING SESSIONS BASED ON GEO-LOCATION INFORMATION - A location based system for conducting learning sessions comprises a geolocation server that is configured to access location information for students and/or teachers. Geo-location information as used herein comprises student or teacher location information or relative proximity of students to each other, teacher to students as well as teacher or students relative to a place of interest. An enrollment module is configured to enroll the students in courses that are taught by teachers. A learning session management module is configured to manage learning sessions associated with the courses based on student location information and/or teacher location information. | 2013-01-03 |
20130004930 | Learner Interaction Monitoring System - The Learner Interaction Monitoring Systems (LiMS) is a web-based application that can interface with any web-based course delivery platform to transform the online learning environment into an active observer of learner engagement. The LiMS ‘event capture model’ collects detailed real-time data on learner behavior in self-directed online learning environments, and interprets these data by drawing on behavioral research. The LiMS offers education and training managers in corporate contexts a valuable tool for the evaluation of learner performance and course design. By allowing more detailed demonstration of ROI in education and training, LiMS allows managers to make the case for web based courseware that reflects appropriate and evidence-based instructional design, rather than budgetary constraints. | 2013-01-03 |
20130004931 | Computer-Implemented Systems and Methods for Determining Content Analysis Metrics for Constructed Responses - Systems and methods are provided for scoring speech. A speech sample is received, where the speech sample is associated with a script. The speech sample is aligned with the script. An event recognition metric of the speech sample is extracted, and locations of prosodic events are detected in the speech sample based on the event recognition metric. The locations of the detected prosodic events are compared with locations of model prosodic events, where the locations of model prosodic events identify expected locations of prosodic events of a fluent, native speaker speaking the script. A prosodic event metric is calculated based on the comparison, and the speech sample is scored using a scoring model based upon the prosodic event metric. | 2013-01-03 |
20130004932 | VOTING WITH YOUR FEET - A method of voting with your feet is disclosed. A notification regarding a survey question is communicated to a player of a computer implemented game. The notification includes an indication of a particular location-based action that is to be performed by the player to answer the survey question. The answer of the player to the survey question is determined based on detection of performance of the particular location-based action by the player. | 2013-01-03 |
20130004933 | INCREASING CONFIDENCE IN RESPONSES TO ELECTRONIC SURVEYS - A survey confidence system is described that improves the quality of responses through electronic surveys by scoring participant responses using confidence metrics. The system assigns a score to actions taken by the participant that potentially indicate fraud, falsification, or duplication and uses the score to eliminate responses that do not reach a threshold level of confidence, or to weight such responses lower than other higher confidence responses. The system defines a series of axes that the system combines to form an overall confidence score. Each axis represents a particular domain about which the system can determine and assign some level of confidence. The system can inject questions into a survey that verify information that does not change, seldom changes, often changes, or changes according to a recognized pattern. Thus, the system allows the benefits and reduced cost of electronic surveys while increasing confidence in responses to ensure trustworthy results. | 2013-01-03 |
20130004934 | METHOD OF ORGANIZING THE POPULACE BY ESTABLISHING NEIGHBORHOOD SOCIAL-SAFETY CLUBS IN EVERY NEIGHBORHOOD AND A CITY-WIDE COMMUNICATIONS NETWORK THAT WILL THEN ALLOW FOR THE ESTABLISHMENT OF A CITY-WIDE EVACUATION PROGRAM - A method of organizing the populace consisting of forming and maintaining a standardized neighborhood social-safety club for every 50-150 adjacent homes sot that they can be trained on disaster preparedness as a group, be able to rapidly evacuate as a group in ant orderly fashion as part of a city-wide evacuation program involving multiplicities of such clubs, be able to shelter-in-place as a group during a disaster, be able to reduce crime in their neighborhood as a group and be able to increase their sense of community by interacting frequently as a group or sub-group, linked to other standardized neighborhood social-safety clubs across the city, thus coordinating their activities, leading to a city-wide social-safety network linked through in-person meetings, a secure online private network, and a standardized radio system using a combination of walkie-talkies and ham radios. | 2013-01-03 |
20130004935 | ONLINE SOCIAL LEARNING SYSTEMS, METHODS, AND COMPUTER PROGRAM PRODUCTS - Provided is a system, method and computer program product for providing interactive online learning. | 2013-01-03 |
20130004936 | SUPERCOOLING PROMOTING AGENT - The present invention discloses a supercooling promoting agent comprising a tannin for producing practical water which does not freeze. As the tannin, a hydrolyzable tannin such as 2,3,6-tri-O-galloyl-α,β-D-hamamelose, 1,2,6-tri-O-galloyl-β-D-glucose, and a vitrification liquid, each of which contains the supercooling promoting agent are useful as a solution or the like for storing a biological material at low temperature. | 2013-01-03 |
20130004937 | SYSTEM FOR EXTENDED STORAGE OF RED BLOOD CELLS AND METHODS OF USE - A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described. | 2013-01-03 |
20130004938 | SYSTEM AND METHOD FOR AUTOMATED EXTRACTION OF MULTI-CELLULAR PHYSIOLOGICAL PARAMETERS - In one aspect the present invention relates to a system | 2013-01-03 |
20130004939 | Fetuin-beads, Manufacturing method thereof and method of concentrating and detecting influenza virus by the same - Fetuin-beads, a manufacturing method thereof and a method of concentrating and detecting influenza virus by the fetuin-beads are disclosed. The method of concentrating and detecting an influenza virus by the fetuin-beads comprises the steps of preparing fetuin-beads; mixing the fetuin-beads and a solution capable of providing salt ions to obtain a fetuin-bead solution; mixing the fetuin-bead solution and a sample comprising the influenza virus to concentrate the influenza virus onto the fetuin-beads to obtain a plurality of fetuin bead-influenza virus combinations; and collecting the fetuin bead-influenza virus combinations and using a virus testing method to detect the influenza virus on the fetuin bead-influenza virus combinations. Therefore, an easy and fast method to detect the influenza virus with timeliness and high accuracy is provided. | 2013-01-03 |
20130004940 | Device for Detecting Analyte in Sample - A device for detecting an analyte in a sample is provided, which comprises: a collecting chamber containing an opening for collecting a liquid sample; a detecting element for detecting an analyte in the liquid sample; and a lid for covering the opening of the collecting chamber. The device further comprises an indicating device thereon to indicate whether or not the lid covers at an appointed position. The operation of the device is very simple. | 2013-01-03 |
20130004941 | PROTEINASE K INHIBITORS, METHODS AND COMPOSITIONS THEREFOR - The synthesis, biological evaluation, and molecular modeling of alkoxysuccinyl-peptidyl-haloalkyl ketones for use as proteinase K inhibitors are described. Sample preparation processes for in situ RNA or DNA analysis using such inhibitors, methods and compositions therefor are provided. | 2013-01-03 |
20130004942 | METHODS OF TESTING FOR INTRACELLULAR PATHOGENS - A first intracellular pathogen in a biological sample that may contain more than one intracellular pathogen is studied by a method comprising the steps of (i) contacting the sample with a population of cells in the presence of an agent inhibiting the reproduction of a second intracellular pathogen; (ii) incubating the cells under conditions that permit the reproduction of the first intracellular pathogen; and (iii) testing material arising from step (ii) for the first intracellular pathogen. | 2013-01-03 |
20130004943 | H5 Subtype-Specific Binding Proteins Useful for H5 Avian Influenza Diagnosis and Surveillance - The invention provides monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes of avian influenza virus (“AIV”). The monoclonal antibodies and related binding proteins are useful for the detection of H5 subtypes of AIV, including the pathogenic H5N1 subtypes. Virus may be detected in formalin preserved, paraffin embedded specimens as well as frozen specimens and biological fluids. Accordingly, the invention provides means for the diagnosis and surveillance of dangerous viral infections. | 2013-01-03 |
20130004944 | H5 Subtype-Specific Binding Proteins Useful for H5 Avian Influenza Diagnosis and Surveillance - The invention provides monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes of avian influenza virus (“AIV”). The monoclonal antibodies and related binding proteins are useful for the detection of H5 subtypes of AIV, including the pathogenic H5N1 subtypes. Virus may be detected in formalin preserved, paraffin embeded specimens as well as frozen specimens and biological fluids. Accordingly, the invention provides means for the diagnosis and surveillance of dangerous viral infections. | 2013-01-03 |
20130004945 | SELECTIVE INHIBITORS OF TRANSLESION DNA REPLICATION - An agent for inhibiting translesion DNA replication comprises a non-natural adenine ribose analog represented by those as set forth in FIG. | 2013-01-03 |
20130004946 | Compositions and Methods for Genetic Manipulation and Monitoring of Cell Lines - The disclosure relates generally to stem cell biology and more specifically to genetic manipulation of stem cells. Methods and compositions using recombinational cloning techniques are disclosed which allow the construction and insertion of complex genetic constructs into embryonic and adult stem cells and progenitor cells. The methods disclosed will allow the harvesting of adult stem cells pre-engineered with integration sites to facilitate early passage genetic modification. | 2013-01-03 |
20130004947 | LUCIFERASE-LINKED ANALYSIS OF DNA-METHYLTRANSFERASE, PROTEIN METHYLTRANSFERASE AND S-ADENOSYLHOMOCYSTEINE AND USES THEREOF - The present invention relates to methods for detecting the activity of DNA (cytosine 5)-methyltransferase, protein methyltransferase or any enzyme that forms S-adenosyl-1-homocysteine (AdoHcy) as a product, and for screening for inhibitors of DNA (cytosine 5)-methyltransferase, protein methyltransferase and any enzyme that forms S-adenosyl-1-homocysteine (AdoHcy) as a product using luciferase-linked assays that convert the S-adenosyl-1-homocysteine (AdoHcy) product to a quantifiable luminescent signal. | 2013-01-03 |
20130004948 | ACTIVE CHEMICALLY-SENSITIVE SENSORS WITH RESET SWITCH - Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions. | 2013-01-03 |
20130004949 | METHODS AND APPARATUS FOR HIGH SPEED OPERATION OF A CHEMICALLY-SENSITIVE SENSOR ARRAY - Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions. | 2013-01-03 |
20130004950 | ASSAY SYSTEMS FOR GENETIC ANALYSIS - The present invention provides assays systems and methods for detection of chromosomal abnormalities and status of single loci associated with monogenic or polygenic traits in a sample containing nucleic acids from a maternal and a fetal source. | 2013-01-03 |
20130004951 | BULKED MUTANT ANALYSIS - The current invention relates to a new strategy for identification, and optional isolation, of a nucleic acid sequence that is expressed in an organism and that is causally related to a particular phenotype (trait of a character) of said organism. With the method of the current invention it has become possible to, in contrast to known methods in the art, efficiently enrich, identify, isolate and/or clone genes in, for example, organism like (crop) plants for which no or only limited information with respect to the genome is available. | 2013-01-03 |
20130004952 | CARTRIDGE FOR BIOCHEMICAL ANALYSES, SYSTEM FOR BIOCHEMICAL ANALYSES, AND METHOD OF CARRYING OUT A BIOCHEMICAL PROCESS - A cartridge for biochemical analyses includes a support, a structure, which is set on the support and contains wells for receiving a solution, and photodetectors on the support, in positions corresponding to respective wells. | 2013-01-03 |
20130004953 | METHODS FOR LOCALIZED IN SITU DETECTION OF mRNA - The present invention relates to the detection of RNA in a sample of cells. More particularly, the present invention relates to the localized detection of RNA in situ. The method relies on the conversion of RNA to complementary DNA prior to the targeting of the cDNA with a padlock probe(s). The hybridization of the padlock probe(s) relies on the nucleotide sequence of the cDNA which is derived from the corresponding nucleotide sequence of the target RNA. Rolling circle amplification of the subsequently circularized padlock probe produces a rolling circle product which may be detected. Advantageously, this allows the RNA to be detected in situ. | 2013-01-03 |
20130004954 | ANALYZER FOR BIOCHEMICAL ANALYSES AND METHOD OF DETERMINING CONCENTRATIONS OF FLUORESCENT SUBSTANCES IN A SOLUTION - An analyzer for biochemical analyses includes a seat for receiving a recipient. A first light source and a second light source illuminate the recipient with a luminous radiation, respectively, in a first excitation band and in a second excitation band, including a first excitation wavelength and a second excitation wavelength of fluorophores of a first type and of a second type. A first image sensor and a second image sensor are oriented so as to receive light emitted by fluorophores contained in the recipient and are, respectively, provided with a first detection filter and a second detection filter, having, respectively, a first detection passband and a second detection passband, including, respectively, a first emission wavelength and a second emission wavelength of the fluorophores of the first type and of the second type. | 2013-01-03 |
20130004955 | Ovary Tumor Markers and Methods of Use Thereof - Newly identified proteins as markers for the detection of ovary tumors, or as therapeutic targets for treatment thereof; affinity ligands capable of selectively interacting with the newly identified markers, methods for tumor diagnosis and therapy using the same. | 2013-01-03 |
20130004956 | DNA ANALYZER - Aspects of the disclosure provide a microfluidic chip to facilitate DNA analysis. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, a dilution domain coupled to the first domain to dilute a PCR mixture received from the first domain, and a second domain that is coupled to the dilution domain so as to receive the amplified DNA fragments. The second domain includes a separation channel that is configured to perform electrophoretic separation of the amplified DNA fragments. In addition, the disclosure provides a DNA analyzer to act on the microfluidic chip to perform an integrated single chip DNA analysis. | 2013-01-03 |
20130004957 | PREVENTION AND TREATMENT OF OSTEOARTHRITIS - Subjects lacking Nfat1 display osteoarthritis in weight-bearing joints. Osteoarthritic changes associated with Nfat1 deficiency are characterized by articular cartilage degradation, articular chondrocyte proliferation/clustering, progressive articular surface destruction, periarticular chondro-osteophyte formation, and exposure of thickened subchondral bone. Methods of treating osteoarthritis, methods of diagnosis and early prediction of the onset of osteoarthritis, and methods for screening drug candidates that may be useful for treatment of osteoarthritis are presented. | 2013-01-03 |
20130004958 | METHOD FOR THE SPECIFIC DETECTION OF LOW ABUNDANCE RNA SPECIES IN A BIOLOGICAL SAMPLE - The present invention relates to a method and a kit for the detection of low abundance RNA species in a biological sample and to a method and a kit for the detection of a mycoplasma contamination in a biological sample. | 2013-01-03 |
20130004959 | SCREENING DEVICE CONTAINING NANOG PROMOTER, SOX2 PROMOTER, LIN 28 PROMOTER, OCT4 PROMOTER AND LUCIFERASE GENE AND SCREENING METHOD THEREOF - A screening device that contains Nanog promoter, Sox2 promoter, Lin28 promoter, Oct4 promoter and luciferase gene and a method thereof is revealed. The screening device is used to find out small molecules that improve activity of the promoters mentioned-above. A reporter plasmid formed by a pStable vector is introduced into stable somatic cells or stem cells with reporter plasmids such as a C2C12 mouse myoblast cell line and a P19 embryonal carcinoma cell line. By the luciferase gene contained in the pStable vector and pluripotent gene promoters placed upstream of the luciferase gene, luciferase expression is assayed by luminescence intensity measured. Thus response and activity of the promoters placed upstream of the luciferase gene is measured and small molecules inducing pluripotency are found out. If a drug can activate all promoters or respective promoter, it can be used as a drug that induces cell pluropatency. | 2013-01-03 |
20130004960 | PHOTON REDUCING AGENTS FOR FLUORESCENCE ASSAYS - The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon reducing agents). The present invention further provides a method for reducing undesirable light emission from a sample (e.g., a biochemical or cellular sample) with at least one photon producing agent and at least one collisional quencher. The present invention also provides a method for reducing undesirable light emission from a sample (e.g., a biochemical or cellular sample) with at least one photon producing agent and at least one quencher, such as an electronic quencher. The present invention also provides a system and method of screening test chemicals in fluorescent assays using photon reducing agents. The present invention also provides compositions, pharmaceutical compositions, and kits for practicing these methods. | 2013-01-03 |
20130004961 | METHODS OF DETECTING A SWEET-SENSITIVE CELL - The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. | 2013-01-03 |
20130004962 | METHOD FOR EVALUATING CELL AGING BY EXPRESSION LEVEL OF COFILIN - The present invention discloses a concept that the expression level of cofilin may reflect the senescent condition of a cell or tissue. According to the findings in present invention, a method for determining the cellular senescent condition in a cell or tissue sample by evaluating the expression level of cofilin is provided. The detection of the expression level of cofilin is also used to screen an effective compound or composition for regulating the senescent condition in target cells. | 2013-01-03 |
20130004963 | Tyrosine, serine and threonine phosphorylation sites - The invention discloses 155 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above. | 2013-01-03 |
20130004964 | METHOD FOR CARRYING OUT REACTIONS IN AN ANALYTICAL DEVICE - Method and system for carrying out heterogeneous chemical or biological reactions are disclosed. The method comprising providing an analytical device having at least one liquid processing unit having at least one reaction chamber and a first inlet channel in fluid communication with the reaction chamber. The method further comprises supplying to the reaction chamber via the first inlet channel or a second inlet channel analyte capturing particles, supplying to the reaction chamber via the first inlet channel or the second inlet channel a liquid sample containing an analyte of interest, and confining by an equilibrium of forces the analyte capturing particles in a particle rearrangement zone within the reaction chamber. The forces comprise a drag force Fd generated by flowing liquids and a counter-oriented force Fg. The method also comprises capturing analytes present in the liquid sample with the particles in the particle rearrangement zone. | 2013-01-03 |
20130004965 | DETECTING AND COUNTING TISSUE - SPECIFIC STEM CELLS AND USES THEREOF - This invention provides methods of determining the number and percent of tissue specific stem cells (TSSCs) in a sample of cells, a population of cells or a sample of tissue. The methods rely on detecting the pattern-specific asymmetric localization of asymmetric self-renewal associated (ASRA) proteins or cell cycle specific proteins (CSSP) in cell undergoing asymmetrical self-renewal, which is a characteristic of TSSCs. The methods can be applied to any situations in which the percent of TSSC is desired such as laboratory research on adult stem cells, in drug development tests, prognostic indicator and therapeutic index, as a diagnostic and prognostic indicator and in monitoring TSSC expansion, e.g., in cell manufacturing processes. | 2013-01-03 |
20130004966 | STRUCTURE OF CYTOKININS AND CYTOKININ RECEPTORS, AND MODULATION OF CYTOKININ SIGNALING - Provided herein are seven high resolution crystal structures showing the cytokinin receptor AHK4 complexed with various naturally occurring and synthetic ligands. Further provided are strategies for modulating cytokinin receptor activity. | 2013-01-03 |
20130004967 | MICROWELL ARRAY ARTICLES AND METHODS OF USE - The disclosure provides microstructured articles and methods useful for detecting an analyte in a sample. The articles include microwell arrays. The articles can be used with an optical system component in methods to detect or characterize an analyte | 2013-01-03 |
20130004968 | Sepsis blood biomarker system - A panel of blood biomarkers for assessing a sepsis condition utilizing an iNOS indicator in combination with one or more indicators of patient predisposition to becoming septic, the existence of organ damage, or the worsening or recovering from a sepsis episode. | 2013-01-03 |
20130004969 | IL-17 Heteromeric Receptor Complex - The present invention relates to Interleukin-17 ligand and receptor family members and the discovery that IL-17 receptor A and IL-17 receptor C form a heteromeric receptor complex that is biologically active. | 2013-01-03 |
20130004970 | METHODS FOR PREDICTION OF CLINICAL OUTCOME TO EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITORS BY CANCER PATIENTS - Disclosed are biomarkers, methods and assay kits for the identification of cancer patients who are predicted to benefit, or not to benefit, from the therapeutic administration of an epidermal growth factor receptor (EGFR) inhibitor. The biomarkers of the present invention include detection of EGFR and HER 2 gene amplification and polysomy, EGFR protein expression, EGFR mutations, phosphorylated Akt protein expression, and various combinations of such biomarkers, as well as the combination of these biomarkers with mutations in the tyrosine kinase domain of the EGFR gene. Increased EGFR gene copy number, increased HER2 gene copy number, increased EGFR protein expression, activated AKT protein expression (phosphorylated AKT) and EGFR mutations are all associated with better outcome for cancer patients treated with EGFR inhibitors. The invention provides a diagnostic paradigm based on each of these tests and combinations of these tests to select cancer patients who will benefit from EGFR inhibitor therapy, as well as a diagnostic paradigm to select cancer patients who will not benefit from EGFR inhibitor therapy. | 2013-01-03 |
20130004971 | CYSTATIN C, beta2 MICROGLOBULIN, alpha1 MICROGLOBULIN AND GENES FOR SAME, ANTIBODY, AND KIT AND METHOD FOR DIAGNOSIS OF FELINE NEPHROPATHY - Proteins respectively having the amino acid sequences represented by SEQ ID NOs: 1, 17 and 32; structural genes respectively encoding the proteins, preferably respectively having the nucleotide sequences represented by SEQ ID NOs: 2, 18 and 33; an antibody capable of specifically binding to feline-derived cystatin C, feline-derived β2 microglobulin or feline-derived α1 microglobulin; a kit for diagnosing feline nephropathy, containing the antibody of the present invention; and a method for diagnosing feline nephropathy using the antibody of the present invention. | 2013-01-03 |
20130004972 | METHOD FOR THE DETECTION OF PREDIABETES - Provided is a method for prediabetes screening by means of methylglyoxal-modified arginine derivative assay, with which it is possible to treat many samples as simply and as safely as with blood sugar assay, and to collect a blood sample taken during a primary health screening in one procedure without imposing any time restraints, complications or risks on the subject. The method for prediabetes screening by means of methylglyoxal-modified arginine derivative assay comprises assaying the methylglyoxal-modified arginine derivative in blood using an assay system which employs an antibody that specifically recognizes methylglyoxal-modified arginine derivative. | 2013-01-03 |
20130004973 | METHODS OF USE FOR AN IMMUNOASSAY DETECTING FRAGMENT Ba - Methods, compositions and kits for detecting the complement Factor B cleavage product Ba in a biological sample are described. These methods, compositions and kits are useful in convenient, reliable and early diagnosis of or ruling out pre-eclampsia in a pregnant human subject. | 2013-01-03 |
20130004974 | EXTRACELLULAR AND MEMBRANE-ASSOCIATED PROSTATE CANCER MARKERS - This document relates to methods and materials involved in identifying, assessing, and monitoring prostate cancer in male mammals. For example, this document provides arrays for detecting polypeptides or nucleic acids that can be used to identify prostate cancer in male mammals. In addition, methods and materials for assessing and monitoring prostate cancer in mammals are provided herein. | 2013-01-03 |
20130004975 | Method of Stabilizing Heme Protein and Storage Solution Therefor - A method of stabilizing a hem protein which is effective against the denaturation and degradation of a hem protein typified by hemoglobin and a storage solution therefor. A method of stabilizing a hem protein and a storage solution therefor characterized in that an iminocarboxylic acid or its salt is made to coexist in a sample containing the hem protein, wherein the above-described iminocarboxylic acid is a compound represented by the following general formula (1) wherein R represents a hydrogen atom or a hydroxyl group; and X's represent each a hydrogen atom, an alkali metal or an ammonium group. | 2013-01-03 |
20130004976 | HUMAN INSULIN ASSAY AND ASSAY REAGENT - A problem of the present invention is to provide an antibody specific to human insulin and an assay and an assay reagent using the antibody capable of accurately assaying human insulin without being affected by porcine insulin. The present invention provides an assay and an assay reagent capable of specifically assaying human insulin by combining a monoclonal antibody specifically reactive with human insulin and nonreactive with porcine insulin and a different anti-human insulin antibody. | 2013-01-03 |
20130004977 | MEASURING CIRCULATING THERAPEUTIC ANTIBODY, ANTIGEN AND ANTIGEN/ANTIBODY COMPLEXES USING ELISA ASSAYS - The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease. | 2013-01-03 |
20130004978 | ANTI-LG3 ANTIBODIES AND USES THEREOF - A method for the prediction of the risk and/or the diagnosis of vascular damage such as acute vascular rejection in a subject, based on the determination of anti-LG3 antibodies levels in a sample from the subject, is disclosed. | 2013-01-03 |
20130004979 | GLYCOSYLTRANSFERASE REVERSIBILITY FOR SUGAR NUCLEOTIDE SYNTHESIS AND MICROSCALE SCANNING - The present invention generally relates to materials and methods for exploiting glycosyltransferase reversibility for nucleotide diphosphate (NDP) sugar synthesis. The present invention provides engineered glycosyltransferase enzymes characterized by improved reaction reversibility and expanded sugar donor specificity as compared to corresponding non-mutated glycosyltransferase enzymes. Such reagents provide advantageous routes to NDP sugars for subsequent use in a variety of biomedical applications, including enzymatic and chemo-enzymatic glycorandomization. | 2013-01-03 |
20130004980 | TWO-WAY, PORTABLE RIBOSWITCH MEDIATED GENE EXPRESSION CONTROL DEVICE - A regulatable gene expression construct comprising a nucleic acid molecule comprising a two-way riboswitch operably linked to a target sequence. Also provided is a library screening strategy for efficient creation of target-specific riboswitches. A theophylline-repressible and IPTG-inducible riboswitch device achieves portable control of gene expression control in a ‘two-way’ manner. The default state of target genes is ON; the targets are switched off by adding theophylline, and switched back to the ON-state by adding IPTG without changing growth medium. The riboswitch device regulates gene expression in a portable, adjustable, and two-way manner with a variety of scientific and biotechnological applications. | 2013-01-03 |
20130004981 | SYSTEM AND METHOD FOR SELECTING MOLECULE INTERACTING WITH PROTEIN PHOSPHATASE - A system and a method for selecting a molecule interacting with protein phosphatase are disclosed. The fluorescence protein detecting system for selecting a molecule interacting with protein phosphatase includes: a scaffold subunit A; a regulatory subunit B; a catalytic subunit C; a first fluorescence protein, which includes a first part and a second part, wherein the first part and the second part are separated from each other; and a second fluorescence protein, wherein the emission spectrum of the second fluorescence protein overlaps with the excitation spectrum of the first fluorescence protein. When the second part of the first fluorescence protein is fused with the regulatory subunit B, the second fluorescence protein is fused with the catalytic subunit C, alternatively. When the second part of the first fluorescence protein is fused with the catalytic subunit C, the second fluorescence protein is fused with the regulatory subunit B. | 2013-01-03 |
20130004982 | METHOD AND APPARATUS FOR MAGNETIC FLOW CYTOMETRY - A magnetic flow cytometry apparatus for detection of cells labeled with magnetic nanoparticles has at least one pair of oppositely oriented magnets to provide between the magnets a first magnetic field region with a low magnetic field strength and to provide at poles of the magnets second magnetic field regions with a high magnetic field strength. The magnetic labeled cells provided within a flow input into the magnetic flow cytometry apparatus are enriched in at least one of the second magnetic field regions and supplied to the first magnetic field region, where a magnetic field is applied to the enriched magnetic labeled cells to measure the magnetic relaxation of the magnetic labeled cells in response to the applied magnetic field. | 2013-01-03 |
20130004983 | COMPOSITIONS AND METHODS FOR ENHANCING ODORANT RECEPTOR ACTIVITY - The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine receptor M3) capable of enhancing odorant receptor activation. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for polypeptide polymorphisms and mutations associated with odorant receptor activation (e.g., polymorphisms and mutations associated with muscarinic actetylcholine receptor polypeptides (e.g., M1, M2 M3, M4, M5)), as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins. | 2013-01-03 |
20130004984 | NEURONAL STIMULATION - A method of activating a latent neural precursor cell population, comprising: (1) providing a neural cell population derived from the hippocampus; (2) introducing the neural cell population to a neurosphere-forming culture medium; and (3) activating the latent precursor cell population by treatment with a β3 adrenergic receptor agonist. | 2013-01-03 |
20130004985 | METHODS AND COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS - Provided herein are methods and compositions useful in treating neurological disorders. | 2013-01-03 |
20130004986 | Use of luminescent Ir(III) and Ru(II) complexes - The present invention relates to the use of luminescent Ir(III) and Ru(II) complexes and their application in electro-chemiluminescence and bio-labelling. The use refers to the labelling and detection of biomolecules. | 2013-01-03 |
20130004987 | APPARATUS AND METHOD FOR IMPROVED OPTICAL DETECTION OF PARTICLES IN FLUID - A number of fluidic-photonic devices for allowing optical detection, systems employing such devices, and related methods of operation and fabrication of such devices are disclosed herein. In at least some embodiments, the devices can serve as flow cytometry devices and/or employ microfluidic channels. Also, in at least some embodiments, the devices are fluidic-photonic integrated circuit (FPIC) devices that employ both fluidic channels and one or more waveguides capable of receiving and/or delivering light, and that can be fabricated using polymeric materials. The fluidic-photonic devices in at least some embodiments are capable of functionality such as on-chip excitation, time-of-flight measurement, and can experience enhanced fluorescence detection sensitivity. In at least some embodiments, the devices employ detection waveguides that are joined by way of a waveguide demultiplexer. In additional embodiments, a variety of techniques can be used to process information received via the waveguides, including an iterative cross-correlation process. | 2013-01-03 |
20130004988 | DISPENSING OF A DIAGNOSTIC LIQUID ONTO A DIAGNOSTIC REAGENT - Biological fluid samples are deposited by methods that produce a uniform layer of the sample over a reagent-containing surface. In one embodiment, a nozzle having multiple openings is used to deposit a sample over the reagent-containing surface simultaneously. In an alternative embodiment, single droplets of the sample are deposited in a pattern on the surface, preferably in a sequence of parallel lines. The reaction between the biological sample and the reagents is read from a spectrographic image of the reagent-containing surface obtained by optical methods. | 2013-01-03 |
20130004989 | METHOD FOR ESTIMATING THE NUMBER OF MICROORGANISMS IN A SAMPLE AND DEVICE FOR IMPLEMENTING SAID METHOD - A method for counting microorganisms present in a biological sample in contact with a culture medium adapted to the growth of said microorganisms, characterized in that it includes the steps of:
| 2013-01-03 |
20130004990 | BIOPSY SUPPORT WITH SECTIONABLE RESILIENT CELLULAR MATERIAL - A histologic tissue sample support device includes a tissue support formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. A resilient cellular material is coupled to the tissue support and is configured to engage and retain tissue in place during processing and embedding. The resilient cellular material is also capable of successful sectioning in the microtome and porous to allow infiltration of the solvents and chemicals used to fix, process and stain tissue, and of embedding material used to embed the tissue while the tissue is retained by the resilient cellular material. | 2013-01-03 |
20130004991 | POSITIVE CYTOMODULINES TO IMPROVE BIOREACTOR PRODUCTIVITY - The present invention relates to the activation of the protein synthesis by controlling the post-transcriptional steps of mRNA translation into proteins. A polypeptide is provided, which is capable of activating said protein translation. The principal industrial application of the invention is the control of recombinant protein production in cultured cells including in bioreactors. | 2013-01-03 |
20130004992 | CELLS DEFICIENT IN CMP-N-ACETYLNEURAMINIC ACID HYDROXYLASE AND/OR GLYCOPROTEIN ALPHA-1,3-GALACTOSYLTRANSFERASE - The present invention provides non-human mammalian cell lines that are deficient in CMP-Neu5Ac hydroxylase (Cmah) and/or glycoprotein alpha-1,3-galactosyltransferase (Ggta1). Also provided are methods for using the cells disclosed herein for producing recombinant proteins with human-like patterns of glycosylation. | 2013-01-03 |
20130004993 | Green Chemical Process to Produce Natural Products - Methods for producing and obtaining natural products from microbial amplification chambers are described. This approach utilizes the concept of green chemistry to synthesize and extract the marine and terrestrial natural products. The method describes techniques to colonize and grow the selected bacteria and to continuously harvest the pharmaceutical agent from the broth without using any commercial solvents. | 2013-01-03 |
20130004994 | METHOD FOR PRODUCING PURE SUGAR SOLUTION, AND METHOD FOR PRODUCING CHEMICAL PRODUCT - The invention provides a method that allows fermentation impeding substances that occur during production of a sugar from cellulose-containing biomass to be removed in an aqueous sugar solution production step, and also provides a method for long-term stable production of an aqueous refined sugar solution that is nearly free from fermentation impeding substances. The aqueous refined sugar solution production method using cellulose-containing biomass as feed material comprises:
| 2013-01-03 |
20130004995 | BETA 1,3-N-ACETYL-D-GALACTOSAMINE TRANSFERASE PROTEIN, NUCLEIC ACID ENCODING THE SAME AND METHOD OF EXAMINING CANCERATION USING THE SAME - The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with β1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them. | 2013-01-03 |
20130004996 | METHODS AND COMPOSITIONS FOR SYNTHESIS OF NUCLEIC ACID MOLECULES USING MULTIPLERECOGNITION SITES - The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different. The invention also provides host cells comprising nucleic acid molecules of the invention or prepared according tb the methods of the invention, and also provides kits comprising the compositions, host cells and nucleic acid molecules of the invention, which may be used to synthesize nucleic acid molecules according to the methods of the invention. | 2013-01-03 |
20130004997 | METHOD FOR PRODUCING SACCHARIFIED SOLUTION - A method for producing a saccharified solution is provided, by which a saccharide recovered as a saccharified solution can be increased. The saccharified solution is obtained by treating a substrate solution containing lignocellulosic biomass as a substrate with a saccharifying enzyme produced by a microorganism to prepare a substrate/saccharifying enzyme mixture liquid, and removing a residue of the substrate from the substrate/saccharifying enzyme mixture liquid. The concentration of the substrate in the substrate/saccharifying enzyme mixture liquid is adjusted to be in the range of 15 to 30% by mass. In the removal of the residue of the substrate, a saccharide adsorbed on the residue is extracted. | 2013-01-03 |
20130004998 | PENTOSE FERMENTATION BY A RECOMBINANT MICROORGANISM - The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods. | 2013-01-03 |
20130004999 | VARIANTS OF THE PROMOTER OF THE GAP GENE CODING FOR GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE - The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism. | 2013-01-03 |
20130005000 | MUTANT rpsA GENE AND METHOD FOR PRODUCING L-AMINO ACID - A method for efficiently producing an L-amino acid utilizing a bacterium belonging to the family Enterobacteriaceae from a fatty acid or an alcohol such as glycerol as a raw material is provided. A bacterium belonging to the family Enterobacteriaceae which is able to produce L-amino acid and harbors an RpsA protein which has a mutation such that the native aspartic acid residue at position 210 is replaced with another amino acid residue is used. This bacterium is cultured in a medium containing a carbon source selected from a fatty acid and an alcohol, and the produced L-amino acid is collected from the medium. | 2013-01-03 |
20130005001 | METHOD FOR PRODUCING NEBIVOLOL - The present invention relates to a method for producing racemic nebivolol represented by general formula (I) | 2013-01-03 |
20130005002 | AMIDASE AND USE THEREOF FOR PRODUCING 3-AMINOCARBOXYLIC ACID ESTERS - Process for producing optically active 3-aminocarboxylic acid ester compounds of general Formula I, and the ammonium salts thereof, | 2013-01-03 |
20130005003 | Secretion of Fatty Acids by Photosynthetic Microorganisms - Recombinant photosynthetic microorganisms that convert inorganic carbon to secreted fatty acids are described. Methods to recover the secreted fatty acids from the culture medium without the need for cell harvesting are also described. | 2013-01-03 |
20130005004 | PRODUCING EICOSAPENTAENOIC ACID (EPA) FROM BIODIESEL-DERIVED CRUDE GLYCEROL - , when cultured with crude glycerol as a carbon source, produces useful polyunsaturated fatty acids such as eicosapentaenoic acid (EPA). The crude glycerol is pretreated to remove soaps and methanol. An exemplary | 2013-01-03 |
20130005005 | Modified Lipids Produced from Oil-Bearing Microbial Biomass and Oils - Chemically modified lipids and methods for their preparation are provided. | 2013-01-03 |
20130005006 | METHOD FOR PRODUCING POLYHYDROXYALKANOIC ACID - Embodiments of the invention relate to the microbial production of polyhydroxyalkanoic acids, or polyhydroxyalkanoates (PHA), from substrates which cannot be used as a source of carbon and/or energy for microbial growth or PHA synthesis and which have microbial and environmental toxicity. According to one embodiment of the invention, a process for the production of PHA is provided wherein an enzyme such as methane monooxygenase is used to convert volatile organic compounds into PHA through the use of microorganisms that are unable to use volatile organic compounds as a source of carbon for growth or PHA production. | 2013-01-03 |