01st week of 2022 patent applcation highlights part 11 |
Patent application number | Title | Published |
20220001004 | T Cell-Directed Anti-Cancer Vaccines Against Commensal Viruses - Immune-based approaches to treat and prevent skin cancer by boosting T cell immunity against commensal HPVs present on skin. Thus, provided herein are compositions comprising: (i) a plurality of antigenic peptides each comprising a sequence of 9-30 amino acids derived from proteins from commensal human papilloma viruses, (ii) a plurality of live or live attenuated commensal human papilloma viruses, (iii) a plurality of antigenic proteins from commensal human papilloma viruses, preferably in virus-like particles, and/or (iv) a plurality of nucleic acids encoding (a) a plurality of antigenic peptides, each comprising a sequence of 9-30 amino acids derived from proteins from commensal human papilloma viruses or (b) a plurality of antigenic proteins from commensal human papilloma viruses; and optionally a T cell adjuvant that increases T cell response to the antigenic peptides. | 2022-01-06 |
20220001005 | IMMUNOGENIC ANTIGEN IDENTIFICATION FROM A PATHOGEN AND CORRELATION TO CLINICAL EFFICACY - Embodiments of the disclosure concern methods of identifying whether or not antigens from a particular pathogen are immunogenic, including the order of their immunogenicity. Other embodiments concern correlations between attributes of T cells and their clinical efficacy, such as mathematical representations thereof. | 2022-01-06 |
20220001006 | VIRUS LIKE NANOPARTICLE COMPOSITIONS AND METHODS THEREOF - The present disclosure provides virus like nanoparticles (VLPs), which are capable of displaying multiple copies of a SARS-CoV-2 antigen, for eliciting protective immunity against a SARS-CoV-2 infection, as well as polypeptides, compositions and methods thereof. | 2022-01-06 |
20220001007 | COMPOSITIONS AND METHODS - The invention relates to a viral vector comprising nucleic acid having a polynucleotide sequence encoding at least one epitope of the varicella-zoster virus (VZV) Gly E antigen, wherein said viral vector is an adenoviral vector. The invention also relates to uses, compositions for use in medical treatments, and methods of medical treatment. | 2022-01-06 |
20220001008 | LIVE SELF-DESTRUCTING BACTERIAL ADJUVANTS TO ENHANCE INDUCTION OF IMMUNITY - Disclosed herein are unique adjuvant compositions comprising an attenuated derivative of a bacterial pathogen that undergoes lysis in vivo. In exemplary embodiments, the bacterial pathogen is a | 2022-01-06 |
20220001009 | NOVEL COMPOSITIONS INCLUDING A THERAPEUTIC ANTIBODIES AND/OR A CHECKPOINT INHIBITOR AND AN INTEGRIN ACTIVATING COMPOUND - Pharmaceutical compositions including one or more integrin activating compounds capable of enhancing an anti-tumor activity of one or more therapeutic antibodies, one or more immune checkpoint inhibitors, or mixtures thereof. | 2022-01-06 |
20220001010 | ADJUVANTING SYSTEMS AND WATER-FREE VACCINE COMPOSITIONS COMPRISING A POLYI:C POLYNUCLEOTIDE ADJUVANT AND A LIPID-BASED ADJUVANT - The present disclosure provides adjuvanting systems comprising: (a) a polyI:C polynucleotide adjuvant; (b) a lipid-based adjuvant;(c) an amphipathic compound; and (d) a hydrophobic carrier. Also provided are vaccine compositions that are water-free or substantially free of water, which comprise the same components together with one or more antigens. The disclosure also provides uses for such compositions in inducing an antibody (humoral) and/or cell-mediated immune response and methods for their use in the treatment of a disease, disorder or ailment ameliorated by an antibody and/or cell-mediated immune response. | 2022-01-06 |
20220001011 | PHOTODYNAMIC THERAPY COMPOSITION - A photodynamic therapy composition, the composition includes a plurality of targeted phthalocyanine gold nanoparticle conjugates, wherein each targeted phthalocyanine gold nanoparticle conjugate includes a plurality of phthalocyanine compounds covalently coupled to a surface of the gold nanoparticle via bio-cleavable linker and a plurality of cancer or tissue targeting agents coupled to the gold nanoparticle. | 2022-01-06 |
20220001012 | NOVEL COMPOUNDS AND USES OF SAME FOR NEAR-INFRARED CHERENKOV LUMINESCENCE IMAGING AND/OR FOR DEEP TISSUE TREATMENT BY CHERENKOV DYNAMIC PHOTOTHERAPY - Compounds of the general structure (I), which includes: a radioactive entity, which is a beta-energy emitter that produces Cherenkov radiation, a fluorophore that absorbs electromagnetic radiation of a wavelength λ ranging from 300 nm to 500 nm; a fluorophore which emits electromagnetic radiation of a wavelength λ ranging from 650 nm to 950 nm and/or is a photosensitizer which produces reactive oxygen species ROSs; and a vector entity, which may be present or absent. Also, the use of these compounds for an application for near-infrared Cherenkov luminescence imaging and/or for the treatment of deep biological tissues by Cherenkov dynamic phototherapy. | 2022-01-06 |
20220001013 | Anaerobic Blood Storage and Pathogen Inactivation Method - A method for reducing hemolysis and microparticle formation during storage of pathogen reduced blood. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced hemolysis. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles. Oxygen and pathogen reduced blood compositions comprising CPAD and riboflavin having reduced hemolysis. Oxygen and pathogen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles. | 2022-01-06 |
20220001014 | COMPOSITIONS AND METHODS FOR INDUCING BIOLOGICAL MIMICRY IN A MAMMAL FOR THE PREVENTION AND/OR TREATMENT OF COVID-19 AND OTHER DISEASES - The present invention is directed to compositions and methods for inducing artificial biological mimicry in a mammal to mimic the favorable immune advantages present in a bat in another mammal, particularly a human subject, and thereby prevent and/or treat COVID-19 and other diseases by administering to the subject a combination of active agents comprising two or more active agents comprising an inhibitor of inflammasome NLRP3, an inhibitor of one or more priming or activation signals of inflammasome NLRP3, and/or an activator of the inhibitor of one or more priming or activation signals of inflammasome NLRP3 alone or in combination with one or more modulators of Kallikrein-Kinin System (KKS) dysregulation, one or more modulators of Renin Aldosterone Angiotensin System (RAAS) dysregulation, one or more modulators of protease dysregulation, and/or one or more modulators of cytokine dysregulation. Pharmaceutical compositions, methods of treatment, methods of genetic testing, and packaged kits are provided. | 2022-01-06 |
20220001015 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS - The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a provided lipid prodrug or a pharmaceutical composition thereof. | 2022-01-06 |
20220001016 | CONJUGATES FOR TARGETING AND CLEARING AGGREGATES - In some embodiments, the disclosure provides for a conjugate comprising: a) a peptide that competes with an Fc fragment of an IgG for binding to an Fc receptor; and b) a targeting moiety that targets molecular aggregates. In some embodiments, the disclosure provides for methods of using the conjugates for treating a disease or disorder associated with aggregate formation. | 2022-01-06 |
20220001017 | MICROMOLECULAR COMPOUND SPECIFICALLYDEGRADING TAU PROTEIN, AND APPLICATION THEREOF - The present disclosure discloses a micromolecular compound specifically degrading tau protein, and an application thereof. The chemical structure of the micromolecular compound specifically degrading tau protein is TBM-L-ULM or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph or N-oxide thereof, TBM being a tau protein-binding moiety, L being a linking group, and ULM being a ubiquitin ligase-binding moiety, the tau protein-binding moiety and the ubiquitin ligase-binding moiety being connected by means of the linking group. The micromolecular compound specifically degrading tau protein may increase tau protein degradation in a cell, thereby decreasing tau protein content. | 2022-01-06 |
20220001018 | TARGETING PLECKSTRIN-2 FOR TREATING CANCER - Disclosed herein are compounds, compositions, and methods for treating cell proliferative diseases and disorders based on present inventors discovery that Pleckstrin-2 (Plek2) can be targeted to treat cell proliferative diseases and disorders. The compositions and methods disclosed herein include or utilize the disclosed compounds as therapeutic agents which inhibit the biological activity or expression of Pleckstrin-2 (Plek2) and collectively may be referred to as “Plek2 inhibitors.” Disclosed are small molecule inhibitors of Plek2 biological activity. The compositions and method may be utilized for treating cell proliferative diseases and disorders that are characterized by elevated levels of Plek2 expression and/or by activation of the phosphatidylinositide 3-kinase (PI3K)/Akt pathway. Cell proliferative diseases and disorders that may be treated using the disclosed compositions and methods may include, but not limited to, myeloproliferative neoplasms (MPNs) such as Philadelphia (Ph)-negative MPNs, and cancers such as acute myeloid leukemia (AML) and cancers characterized by solid tumors. | 2022-01-06 |
20220001019 | RANDOM CONJUGATE MOLECULE AND METHODS OF MAKING AND USING THE SAME - The present invention discloses a random conjugate molecule (CMN), comprising a formula of CG-X-N and methods of making and using the same. The present invention also discloses a composition comprising the CMN and methods of making and using the composition. | 2022-01-06 |
20220001020 | Combination Therapy Method of Treating Myeloproliferative Neoplasms with a Diphtheria Toxin-Human Interleukin-3 Conjugate in Combination with Other Agents - The present invention provides methods for treating or inhibiting a myeloproliferative neoplasm (MPN) in a subject in need thereof, comprising administering to the subject a diphtheria toxin-human interleukin-3 conjugate (DT-IL3) and one or more Jak inhibitors and/or one or more hypomethylating agents. | 2022-01-06 |
20220001021 | METHOD OF MAKING ORAL DOSAGE FORMS - The present invention relates to a method of making an oral dosage form comprising the steps of reacting at least one cell penetrating peptide (CPP), purifying CPP-lipid conjugates, processing a lipid batch to obtain CPP-modified liposomes and incorporating a liposome lyophilisate into an oral dosage form. The present invention further relates to oral dosage forms and oral dosage forms for use in a therapeutic method. | 2022-01-06 |
20220001022 | Immunoconjugates Targeting HER2 - The invention provides an immunoconjugate of formula: | 2022-01-06 |
20220001023 | CATIONIC LIPID COMPOSITIONS FOR TISSUE-SPECIFIC DELIVERY - Provided herein are, inter alia, compositions and methods useful for the in vivo delivery of bioactive agents (e.g., therapeutic or diagnostic agents). The compositions provided herein include cationic lipids, helper lipids and a biostability enhancing agent, which together form a lipid aggregate with the bioactive agent and allow for the systemic delivery of the bioactive agent to, for example, lung tissue without the requirement for biomolecular targeting. | 2022-01-06 |
20220001024 | GUANYLUREA FUNCTIONALIZED PEPTIDES AND PROTEINS FOR THERAPEUTICS - A cell-penetrating peptide (CPP) comprising a plurality of mono(amino acid)s, oligo(amino acid)s, or poly(amino acid)s where a plurality of the amino acids comprise a positively charged guanylurea unit with a small molecule fragment and each of the mono(amino acid)s, oligo(amino acid)s, or poly(amino acid)s comprising a drug attached through a linker. The CPP can he used for treating cancers. | 2022-01-06 |
20220001025 | RNA Particles Comprising Polysarcosine - The present disclosure relates to RNA particles for delivery of RNA to target tissues after administration, in particular after parenteral administration such as intravenous, intramuscular, subcutaneous or intratumoral administration, and compositions comprising such RNA particles. The RNA particles in one embodiment comprise single-stranded RNA such as mRNA which encodes a peptide or protein of interest, such as a pharmaceutically active peptide or protein. The RNA is taken up by cells of a target tissue and the RNA is translated into the encoded peptide or protein, which may exhibit its physiological activity. | 2022-01-06 |
20220001026 | USE OF MRNA ENCODING OX40L TO TREAT CANCER IN HUMAN PATIENTS - The disclosure features methods for treating ovarian cancer, as well as other cancers such as solid tumors, lymphomas and epithelial origin cancers, by administering mRNA encoding an OX40L polypeptide. The disclosure also features compositions for use in the methods. The disclosure also features combination therapies, such as use of mRNA encoding an OX40L polypeptide in combination with a checkpoint inhibitor, such as an anti-PD-L1 antibody. | 2022-01-06 |
20220001027 | Genetically Engineered Skin Cells for the Systemic In Vivo Treatment of Deficient Enzymes, Factors or Proteins - A method for the systemic delivery of an enzyme to treat lysosomal storage disease of a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding an enzyme or factor for expression by the skin cells, wherein the expressed enzyme or factor is secreted by the skin cells and is introduced into the circulatory system of the subject. | 2022-01-06 |
20220001028 | AAV VIRAL VECTORS AND USES THEREOF - Disclosed herein are compositions comprising AAV9 viral vectors and methods of using them to treat SMA patients, e.g., Type II and Type III Spinal Muscular Atrophy (SMA) patients. | 2022-01-06 |
20220001029 | LIPID NANOPARTICLE FORMULATIONS - The invention provides certain specific lipid nanoparticles comprising: (a) one or more nucleic acid molecules; (b) cholesterol; (c) DSPC; (d) PEG-C-DMA; and (b) a cationic lipid of formula CL1 or CL2, and pharmaceutical compositions comprising the lipid nanoparticles. The lipid nanoparticles and pharmaceutical compositions are particularly useful for delivering a nucleic acid to a patient (e.g. a human) or to a cell. | 2022-01-06 |
20220001030 | GENOME EDITING METHODS AND CONSTRUCTS - The present invention relates to a method of integrating an exogenous DNA sequence into a genome of a cell comprising contacting the cell with: a) a donor nucleic acid comprising: —at least one STOP codon and a translation initiation sequence (TIS) or —a ribosomal skipping sequence, and —said exogenous DNA sequence wherein said donor nucleic acid is flanked at 5′ and 3′ by inverted targeting sequences; b) a complementary strand oligonucleotide homologous to the targeting sequence and c) a nuclease that recognizes the targeting sequence. | 2022-01-06 |
20220001031 | ENGINEERED CHIMERIC FUSION PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF - The present disclosure provides compositions and methods for making and using engineered phagocytic cells that express a chimeric antigen receptor having an enhanced phagocytic activity for immunotherapy in cancer or infection. | 2022-01-06 |
20220001032 | COATED UP-CONVERSION NANOPARTICLES - The invention provides novel biocompatible upconversion nanoparticle (UCNP) that comprises a core of cubic nanocrystals (e.g., comprising α-Na Ln | 2022-01-06 |
20220001033 | PHOSPHATE COMPOUNDS FOR DETECTING NEUROLOGICAL DISORDERS - Provided herein are compounds, methods and compositions for determining whether a patient has a neurological disease or disorder is provided, comprising detecting the presence of a detectable target protein, or an accumulated mass thereof, for example, amyloid beta protein or phosphorylated tau protein, or an accumulated mass thereof, in a tissue or a sample of the patient. The detecting may comprise contacting the target protein with a compound described herein. | 2022-01-06 |
20220001034 | NOVEL FORMULATION AND METHOD OF SYNTHESIS - The present invention provides a composition comprising anti-1-amino-3- | 2022-01-06 |
20220001035 | Half-Curcuminoids as Amyloid-Beta PET Imaging Agents - Provided herein are curcumin analogues that are able to interact with amyloid beta (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds as imaging agents of amyloid beta and for the treatment of diseases associated with amyloid beta. Methods of preparing unlabeled and radiolabeled compounds useful for interacting with amyloid beta and pharmaceutical compositions are also provided. | 2022-01-06 |
20220001036 | Half-Curcuminoids as Amyloid-Beta PET Imaging Agents - Provided herein are curcumin analogues that are able to interact with amyloid beta (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds as imaging agents of amyloid beta and for the treatment of diseases associated with amyloid beta. Methods of preparing unlabeled and radiolabeled compounds useful for interacting with amyloid beta and pharmaceutical compositions are also provided. | 2022-01-06 |
20220001037 | FIBROBLAST ACTIVATION PROTEIN (FAP) TARGETED IMAGING AND THERAPY IN FIBROSIS - Excessive deposition of extracellular matrix is a hallmark of Idiopathic pulmonary fibrosis (IPF), it is advantageous to target the cells and the mechanisms associated with this process. By targeting myofibroblasts (specialized contractile fibroblasts) that are key for the development of IPF with drugs conjugated with fibroblast activation protein (FAP), this technology helps minimize the production of extracellular matrix in the lungs and provides a new treatment option for patients diagnosed with IPF. | 2022-01-06 |
20220001038 | CONJUGATES FOR DETECTION OF AXILLARY LYMPH NODE METASTASES - Disclosed are anti-cancer compounds and imaging agents. More specifically, the disclosed agents target carbonic anhydrase IX and XII and their use in the treatment of cancer, in particular breast cancer. Specific compounds are those that have Formula II wherein R | 2022-01-06 |
20220001039 | COMPOSITIONS AND METHODS FOR DETECTING ACE2 EXPRESSION PROFILES - Among the various aspects of the present disclosure is the provision of compositions of imaging agents and methods for use in imaging ACE2 expression profiles. The ACE2 expression profiles may be used for detecting, monitoring, and evaluating ACE2 associated diseases, disorders, and conditions. | 2022-01-06 |
20220001040 | NOVEL PD-L1 BINDING POLYPEPTIDES FOR IMAGING - Provided herein are novel | 2022-01-06 |
20220001041 | CEACAM1 BASED CANCER THERAPY AND DIAGNOSIS - The invention relates to methods and compositions for the treatment and diagnosis of cancers. At least one aspect of the present invention relates to methods and compositions for enhancing the efficacy of tumor-infiltrating lymphocyte (TIL) therapy in the treatment of cancer by negatively modulating the activity of the CEACAM1 protein. | 2022-01-06 |
20220001042 | CEACAM1 MEDIATED PROTECTIVE IMMUNITY - The presently described technology relates to the modulation of specific immune responses to create a protective immunity in the treatment of autoimmune diseases and diseases requiring the transplantation of tissue. In particular, the present technology relates to the suppression of immune responses in a targeted fashion, by increasing the functional concentration of the CEACAM1 protein in a target tissue to create a localized protective immunity for the treatment of autoimmune diseases and diseases requiring the transplantation of tissue. | 2022-01-06 |
20220001043 | CD8 IMAGING CONSTRUCTS AND METHODS OF USE THEREOF - Antigen binding constructs that bind to CD8, as well as formulations and methods of using them, are described herein. | 2022-01-06 |
20220001044 | SANITATION SYSTEMS FOR AIRCRAFT - A sanitization system can include a housing defining an interior volume, and one or more FAR-UVC light sources disposed within the housing and configured to irradiate at least a portion of the interior volume. The interior volume can be configured to receive one or more user hands or portions thereof to sanitize the one or more user hands and/or portions thereof. | 2022-01-06 |
20220001045 | NON-CONTACT FLUID DISPENSER - A wearable non-contact fluid dispenser is provided. An arm band fastened to a user's arm having receptacle configured to hold a compressible pouch, the pouch retaining a volume of sanitation fluid. A flexible elastic tube extends from the pouch to an outlet positioned approximately to the user's palm. A hands-free valve may release sanitation fluid from the pouch to the user's palm enabling the user to sanitize their hands. The flow rate of the sanitation fluid may be controlled by the user. | 2022-01-06 |
20220001046 | DISPENSER OF LIQUID PRODUCTS FOR SANITATION - A dispenser of liquid products for sanitization, such as bactericides, germicides, disinfectants, alcohol gel, moisturizers, among others, featuring innovative construction characteristics which distribute the product onto the user's hands or onto surfaces of various objects, via spraying in micro droplets, enabling a uniform distribution, suitable to be installed in public environments such as restrooms, restaurants, malls, offices and commercial facilities. | 2022-01-06 |
20220001047 | STERILIZATION AND FILTRATION OF PEPTIDE COMPOSITIONS - Methods and devices for sterilizing viscous peptide compositions which have shear thinning rheological properties at high concentrations. | 2022-01-06 |
20220001048 | MATERIALS AND METHODS FOR PHOTOTHERMALLY SELF-DISINFECTING RESPIRATORS - Self-sterilizing filtration materials are disclosed that include at least one polydopamine-functionalized layer. The at least one polydopamine-functionalized layer is configured to heat to a sterilization temperature when illuminated by light with a light intensity. The self-sterilizing filtration materials may be included in a filtering respirator mask. Methods of sterilizing filtration materials and filtering respirator masks containing at least one polydopamine-functionalized layer by exposing to sunlight are also disclosed. In addition, methods of producing a self-sterilizing filtering respirator mask by polydopamine-functionalizing at least one layer of the filtration material in an existing filtering respirator mask. | 2022-01-06 |
20220001049 | VEHICLE DOOR EPIDEMIC PREVENTION DEVICE APPLIED TO PUBLIC TRANSPORTATION VEHICLE - A vehicle door epidemic prevention device applied to a public transportation vehicle is disposed on the public transportation vehicle, especially a bus. The public transportation vehicle has at least one door. The door has a doorway for passengers to enter and exit. The doorway is provided with at least one door panel. The door panel is provided with at least one disinfection unit. The disinfection unit faces the doorway when the door panel is in an open position. The disinfection unit is connected with a control unit for activating the disinfection unit to disinfect the passengers passing through the doorway when the door panel is in the open position, so as to achieve the purpose of epidemic prevention. | 2022-01-06 |
20220001050 | DISINFECTION TOWER - A disinfection tower adapted to receive current when in operation including (a) a support house having a space inside the house adapted to include an exchangeable current supply unit, wherein the house has an elongated shape having a circumference, a top part and a bottom part opposite each other, (b) multiple elongated UVC light sources adapted for radiating microorganisms, wherein each UCV light source is fixed and disposed outside the house at a desired distance from the circumference of the house and in a longitudinal direction relative to the house, and wherein each UVC light source is disposed with a suitable distance configured to eliminate overheating of each UVC light source. | 2022-01-06 |
20220001051 | SCANNING AND DISINFECTING SYSTEM - A disinfection system is disclosed. The disinfection system includes a base, a first arm mechanically coupled to the base at a first joint, a second arm mechanically coupled to the first arm at a second joint, and an emission module mechanically coupled to the second arm at a third joint. The emission module may include a third arm that includes one or more scanners configured to emit electromagnetic energy further configured to disinfect a first surface. The emission module may also include the one or more scanners, focusing lens, a lens frame, and a rotary actuator, wherein the rotary actuator is configured to align one of the one or more scanners with the focusing lens to produce a narrow electromagnetic beam, or position the focusing lens out of alignment with the one of the one or more scanners to produce a broad electromagnetic beam. | 2022-01-06 |
20220001052 | INDOOR LIGHTING APPARATUS INCLUDING ULTRAVIOLET LIGHT SOURCE - An overhead lighting fixture containing both visible light sources and UV light sources is disclosed herein. UV light can sanitize/disinfect the surrounding environment after the environment over a period of about 30-45 minutes. In this way, viruses, germs, bacteria, mold, and the like can be destroyed to clean the air and/or surfaces (e.g., furniture). Accordingly, embodiments of the present invention provide a controllable UV lighting assembly that can produce UV light to sanitize/disinfect an area and can be automatically disabled to prevent UV light exposure to those in the area using a motion sensor. The lighting assembly can produce visible light while the UV light source is disabled. According to some embodiments, the duration of UV light production is controlled by a timer for power savings. | 2022-01-06 |
20220001053 | DRAWER STERILIZATION SYSTEM - A kit for retrofitting an existing drawer with a sterilization system, that utilizes one or more light sources configured to emit UV-C light positioned internally within a drawer casing, the light sources being connected through a switch to a power supply. The kit contains components that can be configured such that when the drawer is closed, the switch closes, causing the light source(s) to turn on and sterilize the contents of the drawer. | 2022-01-06 |
20220001054 | DISINFECTING LIGHT FIXTURE HAVING DETECTION DEVICE - A disinfecting light fixture including a disinfecting lamp and a detection device is provided. The disinfecting lamp is disposed in an indoor space to emit disinfection light in the indoor space. The detection device is coupled to the disinfecting lamp to turn on or off the disinfecting lamp and includes an emitter, an antenna, a receiver, a signal processor and an actuator. The detection device is configured to detect the condition of the indoor space. In response to a human in the indoor space, the detection device turns off the disinfecting lamp. In response to there being no humans in the indoor space, the detection device turns on the disinfecting lamp. | 2022-01-06 |
20220001055 | Helmet Cleaning, Sanitation, and Dispensing System - A helmet rental system keeping the helmets in individual boxes that have a self-cleaning system built into the system to make the helmets safe for reuse. The full surface of the helmet is to be exposed to heat, possible steam, cleaner, one or more rotating brush(es) and/or UV light to clean the surface fully. The helmet holder allows the heat, steam, cleaner, brushes, and light to easily hit the surface. The cleaning system is based on heat and then cool off the box with AC and/or vent system before allowing the helmet to be rented again after each return. Heat comes from vents under the helmet holding system, holding it in place and/or from all around the helmet. Boxes are modular so one could simply remove a few screws to add or remove rows or boxes to the system to expand or reduce the amount of available helmets and configuration. | 2022-01-06 |
20220001056 | Sterilization of Plant Material - Methods and apparatus for sterilizing plant material include disposing plant material in a sub-atmospheric pressure environment, dispersing a non-toxic, non-polymerizable gas into the sub-atmospheric pressure environment, applying an electric field to change the gas into cold plasma, and maintaining exposure of the plant material to the cold plasma until substantially sterilized plant material is obtained, wherein an amount of at least one active constituent in the plant material is substantially unchanged by the sterilizing. The plant material may be | 2022-01-06 |
20220001057 | ENERGY SUPPLY EQUIPMENT - An energy supply equipment for supplying energy to an equipment to be powered is provided, including includes a main body, an energy supply unit, and a disinfection device. The main body includes a setting portion; the energy supply unit is put on the setting portion of the main body, and is operable to be detached from the setting portion wherein after detached from the setting portion, the energy supply unit can be connected to and supply energy to an equipment to be powered and the disinfection device is provided on or near the setting portion such that when the energy supply unit is put on the setting portion, the disinfection device is activated to disinfect the energy supply unit on the setting portion. | 2022-01-06 |
20220001058 | STERILIZING METHOD AND STERILIZER - A sterilizing method for sterilizing a sterilization object housed in a chamber ( | 2022-01-06 |
20220001059 | DECONTAMINATION OF RESPIRATORY EQUIPMENT - Described herein are methods, devices and systems for decontaminating respiratory medical devices and equipment. Decontamination includes removing humidity from an interior of a respiratory equipment decontamination chamber after an interior thereof is sealed to exclude ambient air. The interior of the decontamination chamber is conditioned by introducing vaporized hydrogen peroxide (VHP) thereto to achieve a target concentration, which is maintained at a predetermined concentration for a decontamination period. The interior of the decontamination chamber is then aerated. Other examples are disclosed and claimed. | 2022-01-06 |
20220001060 | SMART UV DISINFECTION POD - Infected hospitals and habitats with antibiotic resistant pathogens are one of the most serious health threats. The lack of potent antibiotics and effective means against viruses creates a need for a solution which will disinfect the environment. This calls for an urgent alternative solution based on different technologies that eliminates the threat before the patient is infected. What is offered is a smart system based on AI technology that maps the most infected multi touch areas, and directs an ultraviolet beam of light to sterilize those surfaces. The light beam will eradicate microbial cells and viruses rapidly cleaning the suspected areas. A pan and tilt scanning of said light beam could be applied over the entire room. The purpose of this invention is to offer a camera-controlled multi-wavelengths UV beam delivery system, capable of disinfection of potential threats. Modes include pan and tilt full room disinfection and air sterilization mode. | 2022-01-06 |
20220001061 | Automated Robotic System And Method For Sanitization And Disinfection - Embodiments disclosed include autonomous robotic systems and methods for disinfecting an environment. An autonomous disinfecting system comprises, in a housing, a first unit comprising a first plurality of UV-C lamps attached to a first wireless base comprising a plurality of wheels. Preferably, the first unit further comprises a docking port for a second unit comprising a second plurality of UV-C lamps attached to a second wireless base, and a motion sensor configured to send a signal to a processing unit comprised in the autonomous disinfecting system wherein the processing unit is configured to shut down the system when it receives a signal indicating a detected movement. | 2022-01-06 |
20220001062 | DISINFECTION OF AIR AND SURFACES WITH ULTRAVIOLET LIGHT - Example systems and methods of UV disinfection of surfaces and/or air are presented which can utilize multiple peak wavelengths of UV light and utilize feedback control with UV light sensors. Some example systems and methods can facilitate sanitation of spaces which can be occupied by people and/or animals such as an interior room or space of a building or mode of transportation, or even an outdoor gathering space. Additionally, or alternatively, some example systems can include a compartment which is configured to block light exposure to people and/or animals during sanitation and into which objects can be placed for sanitation. | 2022-01-06 |
20220001063 | Type of Continuous Disinfection Lighting Lamp - This invention discloses a type of continuous disinfection lighting lamp, which consists of an enclosure, a driving power supply and a lamp board. The above-mentioned lamp board is clamped to the bottom of the enclosure, the above-mentioned driving power supply is located at the upper part or bottom of the lamp board, the above-mentioned bottom of the lamp board is provided with a light source, and the above-mentioned driving power supply and the light source constitute a control connection, and the above-mentioned light source emits the light with the wavelength range between 207 nm to 222 nm, which provides the function of sterilization and disinfection. This lighting lamp provides a continuous disinfection function in addition to the conventional lighting function, and is harmless to human and livestock. | 2022-01-06 |
20220001064 | CLEANING INDICATOR - A cleaning indicator is disclosed for determining the effectiveness of a washing and disinfecting process related to the healthcare, medical device and pharmaceutical fields. The cleaning indicator includes a base, a soil coupon and a cover. The base has a recessed area for receiving the soil coupon and the cover is attached to the base by clip members. The cover has a transparent window for viewing the soil coupon which transparent window optionally may have a small hole therein. The base includes grip members for attaching the cleaning indicator to a tray in a washer-disinfector. The cleaning indicator is placed in the washer-disinfector for medical instruments or the like for determining the efficacy of the wash cycle of the washer-disinfector. | 2022-01-06 |
20220001065 | INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, AND PROGRAM - An information processing apparatus includes an input unit and a control unit. Sensing information sensed in a predetermined space is input into the input unit. The control unit controls, in accordance with a result obtained by analyzing states or attributes of a plurality of users existing in the space on a basis of the sensing information, output of a scent from the scent output apparatus to each of the users for each user. | 2022-01-06 |
20220001066 | METHOD AND SYSTEM OF SENSOR FEEDBACK FOR A SCENT DIFFUSION DEVICE - The disclosure herein concerns a method including receiving at a computer at least one target value of a scent parameter for an environment that is remote from the computer, receiving at the computer a sensed parameter of the environment, and controlling, via the computer, diffusion of a liquid from a source of the liquid in fluid communication with at least one scent diffusion device to achieve the target value of the scent parameter, wherein controlling includes setting or adjusting an operation parameter of the at least one scent diffusion device in response to the sensed parameter. | 2022-01-06 |
20220001067 | PURIFICATION DEVICE OF EXERCISE ENVIRONMENT - A purification device of exercise environment is provided and includes a main body, a purification unit, a gas guider and a gas detection module. The main body has at least one gas inlet and at least one gas outlet. The purification unit, the gas guider and the gas detection module are disposed in the main body. The purification unit filters a gas in an exercise environment introduced through the at least one gas inlet. The gas guider operates continuously to transport the gas in the exercise environment to be introduced through the at least one gas inlet and to flow through the purification unit. The gas detection module detects a gas information and a particulate cleanliness of the air in the exercise environment, and the particulate cleanliness of the gas in the breathing region around the nose of the exerciser reaches 0˜20 μg/m | 2022-01-06 |
20220001068 | SELF-DECONTAMINATING PERSONAL PROTECTIVE EQUIPMENT USING UV LIGHT - This document describes personal protective devices. In one aspect, a personal protective device includes a face cover arranged to cover at least a nose and mouth of a person. The face cover includes one or more airflow channels that provide a path for air to flow between an exterior side of the face cover and an internal side of the face cover, and one or more ultraviolet (UV) light sources arranged to emit UV light into the one or more airflow channels. | 2022-01-06 |
20220001069 | ULTRAVIOLET LIGHT DISINFECTION SYSTEM AND METHOD - A multispectral light source for disinfection is disclosed, including a plurality of light sources with different disinfection peak wavelengths and electronics. Each disinfection peak wavelength is effective for disinfection, and the electronics are configured to drive the plurality of light sources to emit light at the different disinfection peak wavelengths. In a specific embodiment, multispectral light source includes one or more UV-C light sources emitting ultraviolet light in a UV-C range, and one or more UV-A light sources emitting ultraviolet light in a UV-A range. The multispectral light source optionally may further include one or more white light sources emitting white light providing illumination. In a disinfection method, light in the UV-C range is emitted into an occupied space, and light outside of the UV-C range that is effective for inactivating at least one target pathogen is also emitted, optionally simultaneously, into the occupied space. | 2022-01-06 |
20220001070 | Decontamination Reactor for Fluid Purification - An apparatus for treating contaminated fluid has a UV lamp within an elongate housing, typically rectangular shaped. Deflector baffles within the housing create a meandering pathway perpendicular to the lamp for exposing the fluid to the UV light along the entire length of the pathway. Fins create multiple channels in the pathway to substantially increase internal surface area contact with the fluid. A photocatalytic coating on the baffles, fins and internal surfaces of the housing is maintained within a pre-set radial distance, preferably within about 75 mm, from the lamp for optimal creation of a photocatalytic reactant. The fluid flowing along the pathway, including channels, is also maintained in close proximity to the lamp and has adequate time for exposure to the ultraviolet light and photocatalytic reactant for treatment before exiting the housing. Baffles and fins are removably positioned within the housing for convenient maintenance, pathway length alteration or accommodating fluid volume flow adjustment, with little or no housing re-sizing. This apparatus is an affordable and compact environmental protection device capable of “air quality refinement”, especially for building ventilation systems, by mitigating the spread of harmful pathogens and/or toxic chemicals. | 2022-01-06 |
20220001071 | SANITIZING SYSTEMS AND METHODS FOR COMMERCIAL PASSENGER VEHICLES - The invention relates to a sanitation treatment system and methods for use in association with commercial passenger vehicles such as aircraft. The sanitation system may operate along with a filtration system in an air distribution system associated with an aircraft or like commercial passenger vehicles and/or to provide disinfected air and surfaces in the passenger cabin associated with the aircraft or like vehicle. | 2022-01-06 |
20220001072 | AIR CONDITIONER WITH BIPOLAR IONIZATION ASSEMBLY - An air treatment system comprises an air conditioner; a bipolar ionization assembly; and a power supply. The air conditioner may portable and include a wheeled housing; an evaporator or entry grill for ambient air; a condenser grill for hot air discharge; a cold air supply discharge grate; a motor; an evaporator coil; and an evaporator blower intake. The bipolar ionization assembly includes electrical leads, and is mounted by a bracket to the evaporator blower intake to position the electrical leads within the air stream of the evaporator blower intake. The power supply is operably connected to the portable air conditioner and to the bipolar ionization assembly. When mounted in the air conditioner, the bipolar ionization assembly creates an antimicrobial plasma capable of killing harmful pathogens including bacteria, mycoplasma, viruses, mold and odors, and reducing the presence of Volatile Organic Compounds (VOC's), particulates, and static electricity in the air. | 2022-01-06 |
20220001073 | POROUS BIORESORBABLE RADIOPAQUE EMBOLIC MICROSPHERES FOR DRUG DELIVERY - Methods, copolymer materials and devices are provided for embolic arterial interventions (embolization therapy or embolotherapy). More particularly, radiopaque, bioresorbable spherical microparticles for embolization or vascular occlusion therapies, comprising copolymers of iodine-containing, halogenated phenyl-containing units, such as iodinated desaminotyrosine derivatives, and rubbery components, such as polyethylene glycol (PEG), polycaprolactone (PCL), polytetramethylene oxide (PTMO) or polytrimethylene carbonate (PTMC), are provided. The provided microbeads may further contain, or be coated with, therapeutic agents such as paclitaxel, for targeted delivery of the therapeutics. | 2022-01-06 |
20220001074 | Bioadhesive for Soft Tissue Repair - The present invention provides compositions and methods for repair and reconstruction of defects and injuries to soft tissues. Some aspects of the invention provide tissue adhesives comprising a hybrid hydrogel by using a naturally derived polymer, gelatin and a synthetic polymer, polyethylene glycol, wherein the hydrogel is biocompatible, biodegradable, transparent, strongly adhesive to corneal tissue, and have a smooth surface and biomechanical properties similar to the cornea. | 2022-01-06 |
20220001075 | FLOWABLE HEMOSTATIC SUSPENSION - Compositions and methods related to flowable hemostats that crosslink during and/or after application to a bleeding site are generally described. | 2022-01-06 |
20220001076 | A DEGRADABLE COMPLEX OF SYTHETIC POLYMER AND NATURAL EXTRACELLULAR MATRIX FOR VASCULAR GRAFTS WITH RELATED PREPARATION METHODS - The invention relates to the complex of synthetic polymer and natural extracellular matrix for vascular grafts and their preparation methods. The components of biodegradable synthetic polymer in the preparation process can be chosen with different material proportions. The scaffolds with different fiber diameters, different fiber arrangements, different pore sizes and different pore structures can be prepared by electro-spinning, wet-spinning, melt-spinning, 3D printing, pouring, phase separation, particle leaching and other technologies. Among them, the natural extracellular matrix components come from a wide range of sources such as vascular tissues from different kinds of animals including arteries and veins of pigs and cattle or vascular tissues from human donors including umbilical cord vessels, etc. And its composition and content can be flexibly adjusted according to the demand. The composites and artificial vessels prepared by this technology not only have good mechanical properties, controllable spatial structure and suitable degradation rate, but also have excellent biocompatibility and bioactivity. The preparation process of the invention is simple, the controllability is high, the preparation condition is mild, and is suitable for large-scale industrial production. | 2022-01-06 |
20220001077 | Liquid Crystalline Collagen Materials and Use in Connective Tissue Repair - Compositions and methods are provided to accelerate and improve wound repair and reconstruction of connective tissue structures, including tendons, by assembly of collagen using liquid crystalline collagen. The compositions and methods can be used to treat various forms of connective tissue injury or to prevent or slow degeneration to vulnerable tendons that are generally refractory to repair. | 2022-01-06 |
20220001078 | THE SYSTEM OF AN ELEMENT USED FOR THE CREATION OF HEART VALVE, THE METHOD OF MANUFACTURING OF MODIFIED BACTERIAL CELLULOSE (BC), THE SET AND THE ELEMENT USED IN CARDIO SURGERY - The subject of the invention is the system of an element used for manufacturing heart valve, the method of manufacturing of modified bacterial cellulose (BC) with the use of | 2022-01-06 |
20220001079 | NANOFIBER REINFORCEMENT OF ATTACHED HYDROGELS - Described herein are hydrogels attached to a base with the strength and fatigue comparable to that of cartilage on bone and methods of forming them. The methods and apparatuses described herein may achieve an attachment strength between a hydrogel and a substrate equivalent to the osteochondral junction. In some examples the hydrogel may be a triple-network hydrogel (such as BC-PVA-PAMPS) that is attached to a porous substrate (e.g., a titanium base) with the shear strength and fatigue strength equivalent to that of the osteochondral junction. | 2022-01-06 |
20220001080 | MELT-AND-MELD APPROACH TO REPAIR TISSUE DEFECTS - The present invention is a multi-stage treatment that heals tissue or organ damage (e.g., linear defects, fissures, and fibrillations, as well as focal and large defects) in collagen-rich tissues and organs such as articular cartilage. The present invention includes methods 1) to prime tissues in preparation for treatment, which comprises “melting” the tissue matrix, 2) to add or fill the damaged area with a “melding” agent, comprising of endogenous or exogenous tissue matrix, with or without cells, with or without exogenous biomaterials, and with or without endogenous or exogenous enzymes, such that the melding agent enhances anchoring into the defect for the purpose of integration and/or tissue healing. The Melt-and-Meld process can also be applied in conjunction with any existing treatments of tissue or organ defects. | 2022-01-06 |
20220001081 | SURFACE TREATED BIOCOMPOSITE MATERIAL, MEDICAL IMPLANTS COMPRISING SAME AND METHODS OF TREATMENT THEREOF - Reinforced biocomposite materials having a unique treated surface, in which the surface may comprise a plurality of layers. According to at least some embodiments, medical implants are provided that incorporate novel structures, alignments, orientations and forms comprised of such reinforced bioabsorbable materials, as well as methods of treatment thereof. | 2022-01-06 |
20220001082 | SKIN PROTECTANT FILM INCLUDING SKIN HEALTH INGREDIENTS - A no-sting skin protectant film forming composition is formulated with a film forming polymer having both polar and nonpolar characteristics, a no-sting nonpolar solvent system, and at least one skin health ingredient. The no-sting skin protectant film forming composition is configured to form a protective film on a skin surface after the solvent system evaporates. | 2022-01-06 |
20220001083 | METHOD FOR THE MODIFICATION OF A DEVICE SURFACE BY GRAFTING A CD31-DERIVED PEPTIDE ONTO THE SURFACE OF SAID DEVICE - Disclosed is a method for the modification of the surface of a metallic implantable device for interventional neuroradiology by grafting a CD31-derived peptide onto the surface of the device, wherein the CD31-derived peptide consists of a sequence selected from: SEQ ID NO: 2 to 8, SEQ ID NO: 12 to 79, and SEQ ID NO: 81, the method includes: a) coating a polydopamine layer onto the surface of the device in order to obtain a polydopamine coated surface; b) modifying the polydopamine coated surface by adding a linker including at least one reactive moiety chosen from alkyne functions, to obtain a modified polydopamine coated surface; and c) adding a CD31-derived peptide including an azide terminal group and its reaction with the alkyne function of the linker of step b), to obtain a polydopamine coated surface grafted by a CD31-derived peptide. | 2022-01-06 |
20220001084 | COMPOSITE STINT APPARATUS AND FABRICATION METHOD - The present disclosure is generally related to a stent with one more layer of graphene added to a stint that will be inserted into the body of a patient. Such a stint may be inserted into a vein or artery of a patient in order to increase blood flow, to maintain blood flow, or to prevent a vein or artery from collapsing. The graphene added to the stint provides improved biocompatibility of the stint and reduces risks associated with conventional stints. Stints consistent with the present disclosure may also include growth factors that help bind the stint to specific receptors or target cells. Stints of the present disclosure may include a monolayer, a bilayer, or multi-layers of graphene adhered to the surface of the stent. The stint may then coated with a growth factor. | 2022-01-06 |
20220001085 | BIOABSORBABLE STENT SYSTEM - A bioabsorbable stent system may comprise one or more bioabsorbable stents and one or more restoration agents, wherein the one or more restoration agents are suitable for a targeting position and are coated on the surface of the bioabsorbable stent. A bioabsorbable stent system may comprise one or more bioabsorbable stents and one or more bioabsorbable films, wherein the bioabsorbable films are loaded with restoration agents and/or drugs suitable for a targeting position. | 2022-01-06 |
20220001086 | Calculating A Depletion Time During Dialysis - The disclosure relates to a dialysis machine that comprises a dialyzer, a fluid source, a first line connected to the fluid source, and a container containing bicarbonate. The container connects to the first line and the fluid flows from the fluid source, through the first line, to the container. The dialysis machine further includes a second line connected to the container, a flow rate sensor connected to at least one of the lines, a pressure sensor configured for detecting fluid pressure of the container, a display, and a data processing apparatus. The data processing apparatus is configured to receive signals from the flow rate sensor and the pressure sensor. The data processing apparatus is configured to calculate a size of the container based on the received signals. | 2022-01-06 |
20220001087 | DIALYSIS MACHINE - Embodiments of the present disclosure include a dialysis system having a disposable cartridge which includes one or more flowpaths arranged on or within the cartridge. | 2022-01-06 |
20220001088 | NEONATAL AND PEDIATRIC BLOOD FILTRATION SYSTEM - A blood filtration system may to couple to an infusion pump that is external to the blood filtration system. The blood filtration system may include a blood circuit, for instance a variable-volume blood circuit. An infusion port may be in communication with the blood circuit and may receive an infusion fluid pumped by the infusion pump. A filtration pump may extract a filtrate fluid from a filter. The filtrate fluid may include filtered plasma constituents. A fluid characteristic sensor may measure one or more of pressure or flow rate of the infusion fluid pumped by the infusion pump. A controller may monitor the fluid characteristic sensor to determine a change in the pressure or flow rate of the infusion fluid. The controller may modulate a speed of the variable-speed filtration pump based on the change in the pressure or flow rate of the infusion fluid. | 2022-01-06 |
20220001089 | Removal Of Microbubbles Through Drip Chamber Nucleation Sites - A drip chamber is provided that includes a hollow body and a nucleation column extending into the interior of the hollow body or formed on the inner surface of a drip chamber sidewall. The nucleation column can be formed with, or treated by a treatment to include, microfeatures or other surface properties that provide nucleation sites for the nucleation and amalgamation of microbubbles. The drip chamber can include a bubble catcher in the bottom of the hollow body and the nucleation column can extend from the bubble catcher into the interior of the hollow body. Methods of making such drip chambers are also provided. | 2022-01-06 |
20220001090 | SYSTEM AND METHOD FOR DETECTING VENOUS NEEDLE DISLODGEMENT - In one aspect, a method and system for detecting a change in fluid dynamics of a fluid flowing through an extra-corporeal circuit is disclosed, which includes establishing an acoustic wave resonance across a transverse dimension of at least a portion of a line associated with the extra-corporeal circuit through which the fluid flows, monitoring a phase signal of the resonant acoustic wave, and identifying occurrence of a change in fluid dynamics of the flowing fluid when the observed phase signal of the resonant acoustic wave indicates a deviation from the expected fluid flow signature. The change in fluid dynamics can be used to indicate a venous needle dislodgement event. | 2022-01-06 |
20220001091 | System for Liquid Component Fractionation and Application Method Thereof - A system for liquid component fractionation includes a first container, a second container, a tunnel connecting member and a stopcock valve. The stopcock valve is a three-way valve disposed at the tunnel connecting member and is rotatable to align one of three ports of the stopcock valve to a collection outlet member of the tunnel connecting member, so as to facilitate collection of a fractionated layer from a liquid after the system is centrifuged. | 2022-01-06 |
20220001092 | ARTHROSCOPIC DEVICES AND METHODS - A fluid management system includes a pump connectable to a fluid source. An inflow line removably connects to a cannula for delivering a fluid flow from the pump into a surgical site, such as a joint cavity. A flow pressure sensor is coupled to measure flow pressure in the inflow line and produce a measured pressure value, A controller is connected to the pump and the flow pressure sensor, and the controller maintains a pressure set point by controlling a pump speed based on a backpressure-adjusted pressure value calculated by subtracting a backpressure value selected from a backpressure table from the measured pressure value. The BAPV is monitored to determine whether the BAPV deviates outside an initial BAPV range, and corrective measure are taken should such deviations occur. | 2022-01-06 |
20220001093 | Sinus Dilation Catheter - A balloon dilation catheter includes a substantially rigid inner guide member and a movable shaft coupled to a balloon that is slidably mounted on the substantially rigid inner guide member. To treat a sinus cavity of a subject using the balloon dilation the substantially rigid inner guide member is advanced into a drainage pathway of the sinus (e.g., frontal recess or maxillary sinus) of the subject via a nasal passageway. The shaft and balloon are advanced in a distal direction over the substantially rigid inner guide member to place the balloon in the drainage pathway. The balloon is inflated to expand or otherwise remodel the drainage pathway. | 2022-01-06 |
20220001094 | NEGATIVE-PRESSURE THERAPY WITH PNEUMATICALLY-ACTUATED INSTILLATION - New and useful systems, apparatuses, and methods for providing negative-pressure therapy with instillation of topical treatment solutions are described. An apparatus may comprise an exudate container, a solution source, and a pneumatically-actuated instillation regulator. The instillation regulator may be coupled to the exudate container and to the solution source, and negative pressure from a negative-pressure source can actuate the instillation regulator. In some embodiments, a negative-pressure source may be configured for a negative-pressure interval and a venting interval, and the instillation regulator can be configured to draw instillation solution from the solution source during a negative-pressure interval and to instill the solution to a dressing during a venting interval. | 2022-01-06 |
20220001095 | System And Apparatus For Preventing Therapy Unit Contamination - In some examples, provided is a fluid blockage device for use with a reduced-pressure source for treating a tissue site with reduced pressure. The fluid blockage device may be configured to preclude fluid communication through a port fluidly coupled to the reduced-pressure source when the fluid blockage device contacts a liquid. Other devices, systems, and methods are disclosed. | 2022-01-06 |
20220001096 | LOW-PROFILE FLUID CONDUCTORS WITH TREATMENT INDICATORS - An apparatus for use in treating a tissue site with negative pressure, which may comprise a fluid path between a first end and a second end. The fluid conductor may additionally comprise a plurality of pressure indicators configured to indicate a pressure state between the first end and the second end. In some examples, the fluid conductor may be fluidly coupled to a source of negative pressure and a dressing, which can be configured to be applied to a tissue site for treatment with negative pressure. | 2022-01-06 |
20220001097 | NEGATIVE PRESSURE DRESSING AND METHOD OF USING SAME - Disclosed herein are apparatuses and methods for treating, a wound by applying reduced or negative pressure to the wound. The apparatus can include a wound cover, a fluid collection container, a vacuum pump, an inflation pump, and one or more conduits. The wound cover can be configured to move between at least a relatively rigid, generally raised position and a relatively flexible, generally collapsed position according to a predetermined program or in response to input from a user or one or more sensors. In some embodiments, the wound cover can be configured to move between at least the relatively rigid, generally raised position and the relatively flexible, generally collapsed position by adjusting the air pressure in one or more channels in the wound cover or by adjusting the length of piezoelectric or other length changing material supported by the wound cover. | 2022-01-06 |
20220001098 | COMPRESSIBLE WOUND FILLERS AND SYSTEMS AND METHODS OF USE IN TREATING WOUNDS WITH NEGATIVE PRESSURE - Apparatuses and methods disclosed herein relate to various embodiments of wound fillers that, in some cases, preferentially collapse in one direction as compared to another direction. Such apparatuses and methods may aid in the closure of wounds and may further be used in combination with pressure sensors and controllers to provide for controlled collapse of the wound fillers. | 2022-01-06 |
20220001099 | CONDENSATE ABSORBING AND DISSIPATING SYSTEM - A dressing for treating a tissue site may include a base layer, a sealing member, a first and a second wicking layer, and an absorbent layer. The base layer may have a plurality of apertures and may be adapted to cover the tissue site. The sealing member and the base layer may define an enclosure. The first and the second wicking layer may each be disposed in the enclosure with the absorbent layer positioned between the first and the second wicking layer. A conduit comprised of an absorbent material that is vapor permeable and liquid impermeable may be in fluid communication with the dressing for providing reduced pressure to the dressing. Other dressings, systems, and methods are disclosed. | 2022-01-06 |
20220001100 | WOUND THERAPY SYSTEM WITH BLOCKAGE AND LEAK DETECTION - A wound therapy system includes a single conduit fluidly connecting a wound site to a. removed fluid canister. A negative pressure circuit is defined by the wound site, the conduit, the removed fluid canister and tubing extending between the removed fluid canister and a pneumatic pump that applies negative pressure to the negative pressure circuit. A method of operating the wound therapy system includes profiling and benchmarking pressure decay within the negative pressure circuit against previous and/or expected pressure decay to identify any new or sudden anomalies that occur during the operation of the wound therapy system. The wound therapy system may additionally alert a user to such anomalous operation of the wound therapy system and/or identify and alert a user to an underlying cause (e.g, blockage and/or leak, etc.) that is responsible for the anomalous readings. | 2022-01-06 |
20220001101 | FLUID REMOVAL MANAGEMENT AND CONTROL OF WOUND CLOSURE IN WOUND THERAPY - Embodiments of negative pressure wound therapy systems and methods for operating the systems are disclosed. In one embodiment, a negative pressure wound therapy apparatus can include a wound dressing, a negative pressure source, and a controller. The negative pressure source can provide negative pressure via a fluid flow path to the wound dressing. The controller can monitor a rate of fluid removal from the wound, wirelessly communicate the rate of fluid removal to a remote device, and output an indication when the rate of fluid removal meets a threshold. | 2022-01-06 |
20220001102 | TRANSSEPTAL ACCESS DEVICE AND METHOD OF USE - Systems, devices, and methods are provided for transseptal access of septa within a patient. The device can be advanced to a septum, e.g., towards a fossa ovalis. Instead of applying positive pressure to “tent” the septum, a negative pressure is applied to a lumen within a sheath, e.g., within an elongated member slidable within the sheath, via a negative pressure source such as a syringe on the proximal end of the sheath. This results in the septum pulling inward. The sheath employs a stationary needle-like central core component contained within the lumen of the sheath that punctures the septum when the same is pulled passed it by the negative pressure. The stationary needle-like central core component may be hollow and may form a portion of the elongated member or may be coupled to a distal end thereof | 2022-01-06 |
20220001103 | INTEGRATED MULTI-MEDICATION TREATMENT DELIVERY SYSTEM - Treatment delivery apparatuses include a treatment administration device, a multi-lumen catheter reversibly couplable with the treatment administration device, and a controller. The treatment administration device has a housing cartridge-pump interfaces disposed within the housing, each cartridge-pump interface being reversibly couplable with a medication cartridge type. The treatment administration device further includes pumps disposed within the housing, each pump being in fluidic connection with at least one cartridge-pump interface. The controller enables the treatment administration device to: receive a treatment selection, determine available medications based upon medication cartridges coupled with the cartridge-pump interfaces, and administer a treatment to the multi-lumen catheter, based at least upon the treatment selection. | 2022-01-06 |