01st week of 2022 patent applcation highlights part 23 |
Patent application number | Title | Published |
20220002206 | REFRACTORY ARTICLES AND METHODS FOR FORMING SAME - A refractory article includes a body having a first portion defining at least a portion of a first exterior surface of the body, the first portion including a carbide, and further including a second portion defining at least a portion of a second exterior surface of the body opposite the first exterior surface, the second portion including an oxide, and a thermal conductivity difference (ΔTC) of at least 10 W/mK between the first exterior surface and the second exterior surface, and an average Shell Temperature of not greater than 400° C. | 2022-01-06 |
20220002207 | PRESSED AND SELF SINTERED POLYMER DERIVED SiC MATERIALS, APPLICATIONS AND DEVICES - Organosilicon chemistry, polymer derived ceramic materials, and methods. Such materials and methods for making polysilocarb (SiOC) and Silicon Carbide (SiC) materials having 3-nines, 4-nines, 6-nines and greater purity. Processes and articles utilizing such high purity SiOC and SiC. | 2022-01-06 |
20220002208 | PROCESS FOR OBTAINING COMPOSITE, ULTRA-REFRACTORY, FIBRE-REINFORCED CERAMIC MATERIALS - The present invention relates to a process for preparing a composite, ultra-refractory, fibre-reinforced ceramic material obtained through the infiltration of carbon and/or silicon carbide fibres with a ceramic suspension comprising yttrium, lanthanum and/or scandium compounds, and the subsequent densification of the composite. The fibre-reinforced UHTC compounds obtained by the process can be used for making items intended for use in extreme temperature and pressure conditions. | 2022-01-06 |
20220002209 | Protective Coating for Ceramic Matrix Composites - An article has a substrate and a layer atop the substrate. The layer has: a matrix comprising at least one of hafnium silicate (HfSiO | 2022-01-06 |
20220002210 | ANTI-CAKING FERTILIZER COMPOSITIONS - A particulate fertilizer coating composition or a coated fertilizer containing a solid acidic particulate material and a solid basic particulate material. The coating composition and coated fertilizer are each stable, chemical compatible with other fertilizers, and/or are abrasion resistant. | 2022-01-06 |
20220002211 | AMMONIUM SULFATE FERTILIZER WITH WATER-SOLUBLE MICRONUTRIENTS - A fertilizer composition, comprising solid granules each including a homogeneous blend of ammonium sulfate, a water insoluble oxide of a micronutrient metal, and a water-soluble sulfate of the micronutrient metal. A method of forming a fertilizer composition, comprising the steps of: combining ammonium sulfate and a water insoluble oxide of a micronutrient metal; granulating the ammonium sulfate and water insoluble oxide of the micronutrient metal in the presence of a liquid to initiate reaction of a portion of the ammonium sulfate with a portion of the water insoluble oxide of the micronutrient metal to form ammonia and a water-soluble sulfate of the micronutrient metal; and producing a fertilizer composition in the form of solid fertilizer granules each comprising a homogeneous blend of ammonium sulfate, the water insoluble oxide of the micronutrient metal, and the water-soluble sulfate of the micronutrient metal. | 2022-01-06 |
20220002212 | PROCESS FOR THE REDUCTION OF GAS EMISSION FROM FARM MANURE - The present invention relates to a method and a use of a composition, in each case for reducing the emission of environmentally harmful climate gases methane and/or carbon dioxide from farm manures during its storage. In some examples, the method and use involves bringing a composition comprising calcium cyanamide into contact with the farm manure. | 2022-01-06 |
20220002213 | DEPOSING INITIARY COMPOSITIONS - There is provided a composition and method of deposing an initiatory composition, said composition, comprising a:
| 2022-01-06 |
20220002214 | PROCESS FOR CONVERTING C2-C5 HYDROCARBONS TO GASOLINE AND DIESEL FUEL BLENDSTOCKS - A process for converting C2-5 alkanes to higher value C5-24 hydrocarbon fuels and blendstocks. The C2-5 alkanes are converted to olefins by thermal olefination, without the use of a dehydrogenation catalyst and without the use of steam. The product olefins are fed to an oligomerization reactor containing a zeolite catalyst to crack, oligomerize and cyclize the olens to the fuel products which are then recovered. Optionally, hydrogen and methane are removed from the product olefin stream prior to oligomerization. Further optionally, C2-5 alkanes are removed from the product olefin stream prior to oligomerization. | 2022-01-06 |
20220002215 | Methods for Limiting Water in Recycled Solvent During Linear Alpha Olefin Syntheses - Linear alpha olefins (LAOS) may be formed by oligomerization of ethylene in the presence of a Ziegler-type catalyst. The presence of trace water during oligomerization can result in unwanted formation of insoluble higher oligomers or polymer. Methods for limiting the presence of water during ethylene oligomerization reactions may include separating residual ethylene and 1-butene from an LAO product stream to form a higher LAO-enriched stream comprising C | 2022-01-06 |
20220002216 | Method for Preparing Aromatic Hydrocarbons by Hydrocracking Polymer Containing Aromatic Ring - Disclosed is a method for preparing aromatic hydrocarbons by hydrocracking a polymer containing aromatic rings, which includes reacting the polymer fragment with hydrogen under the action of a catalyst at a temperature of no more than 350° C.; separating a reaction product to obtain the aromatic hydrocarbons. The catalyst comprises a carrier and an active ingredient supported on the carrier, the active ingredient is at least one selected from Ru, Rh, Pt, Pd, Fe, Ni, Cu and Co, the carrier is at least one selected from metal oxide, phosphate, molecular sieve, SiO | 2022-01-06 |
20220002217 | METHOD FOR ADSORPTION AND SEPARATION OF PROPYLENE, PROPYNE, PROPANE AND PROPADIENE - The present invention discloses a method for separating propylene, propyne, propane and propadiene from mixed gas, wherein, comprising: a high purity component can be obtained as metal-organic frameworks as adsorbents through adsorptive separation and purification of a mixed gas containing propylene, propyne, propane and propadiene a general structural formula of the metal-organic framework material is [M(C | 2022-01-06 |
20220002218 | Compound and an Organic Semiconducting Layer, an Organic Electronic Device and a Display or Lighting Device Comprising the Same - The present invention relates to a compound of Formula (I): an organic semiconducting layer comprising the same, an organic electronic device comprising the organic semiconducting layer and a display device or a lighting device comprising the organic electronic device. | 2022-01-06 |
20220002219 | CATALYTIC HYDROGENATION OF FLUOROOLEFINS, ALPHA- ALUMINA SUPPORTED PALLADIUM COMPOSITIONS AND THEIR USE AS HYDROGENATION CATALYSTS - A hydrogenation process is disclosed. The process involves reacting a fluoroolefin with H | 2022-01-06 |
20220002220 | Process for Making Ethers via Enol Ethers - The present invention relates to a process for preparing ethers, particularly unsymmetrical ethers, and preferably ethers suitable for use as base stocks for lubricant compositions. In particular, the process involves the reaction of a branched-chain aldehyde and a branched-chain alcohol to form an enol ether and conversion of the enol ether to a saturated ether by reduction. | 2022-01-06 |
20220002221 | PROCESS FOR THE DIRECT ALPHA-METHYLENATION OF KETONES - The invention relates to a process for preparing an α-methylene ketone comprising the step of reacting a ketone with formaldehyde in the presence of a catalyst which is an organic compound comprising at least one acid function or the corresponding salt, ester or amide thereof and at least one amine function or the corresponding ammonium salt, or a zwitterion thereof. | 2022-01-06 |
20220002222 | ATTRACTANT COMPOSITION FOR THE SPECIES DELOTTOCOCCUS ABERIAE, METHODS FOR THE MONITORING, DETECTION AND/OR CONTROL OF THE PEST - The present invention relates to the compound (4,5,5-trimethyl-3-methylenecyclopent-1-en-1-yl)methyl acetate and to an attractant composition for insects of the species | 2022-01-06 |
20220002223 | PROCESSES FOR PREPARING NITROSYLATED PROPANEDIOLS, COMPOSITIONS COMPRISING THE SAME, AND MEDICAL USES THEREOF - Disclosed is a process for the synthesis of mono- and bis-nitrosylated propanediols, as well as compositions and pharmaceutical formulations that includes the compounds. The process proceeds by reacting a corresponding propanediol that is not nitrosylated with a source of nitrite, optionally in the presence of a suitable acid. When the source of nitrite is an organic nitrite, reacting step is performed in a suitable organic solvent, and when the source of nitrite is an inorganic nitrite, the reacting step is performed in a bi-phasic solvent mixture comprising an aqueous phase and a non-aqueous phase. Also disclosed are methods of treating a condition wherein administration of nitric oxide (NO) has a beneficial effect by administering said compounds, compositions or formulations. | 2022-01-06 |
20220002224 | METHOD FOR SYNTHESIZING 2-(1-CYCLOHEXENYL)ETHYLAMINE - A method for synthesizing 2-(1-cyclohexenyl)ethylamine. Cyclohexanone (II) is reacted with a Grignard reagent in a first organic solvent to produce 1-vinylcyclohexanol (III), which is then subjected to chlorination and rearrangement reaction with a chlorinating reagent in a second organic solvent in the presence of an organic base to synthesize (2-chloroethylmethylene)cyclolxane (IV). Then (2-chloroethylmethylene)cyclohexane (IV) and urotropine are subjected to quaternization in a third organic solvent to synthesize N-cyclohexylidene ethyl urotropine hydrochloride (V). Finally, the N-cyclohexylidene ethyl urotropine hydrochloride (V) undergoes hydrolysis and rearrangement reaction in a solvent in the presence of an inorganic mineral acid to synthesize 2-(1-cyclohexenyl)ethylamine (I). | 2022-01-06 |
20220002225 | COMPOUND COMPRISING 1-ACETYL-6-FLUORO-2,2,4-TRIMETHYL-1,2,3,4-TETRAHYDROQUINOLINE - A compound of Formula (VI), wherein ‘n’ and ‘R’ are selected so that the compound comprises 1-acetyl-6-fluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline of Formula (IX): | 2022-01-06 |
20220002226 | Amorphous Form of Chelating Agents and Process for Preparing them - An amorphous form of a chelating agent is provided, in particular wherein the chelating agent comprises ethylenediaminetetraacetic acid/edetic acid (EDTA), diethylenetriaminepentaacetic acid/pentetic acid (DTPA), nitrilotriacetic acid (NTA), amino tris(methylenephosphonic acid) (ATMP), ethylenediamine tetramethylene phosphonic acid (EDTMP), 1-hydroxyethane 1,1-diphosphonic acid (HEDP), ethylenediaminedisuccinic acid (EDDS), iminodisuccinic acid (IDS), hydroxamic acid, oxalic acid, galactaric acid, metaphosphoric acid, or phytic acid, or a salt of any one or more of the above acids, or a mixture of two or more of any of the above acids or salts thereof. | 2022-01-06 |
20220002227 | CRYSTALLINE FORMS OF METYROSINE - The disclosure provides crystalline compositions comprising D-metyrosine and L-metyrosine, pharmaceutical formulation comprising one or more crystalline composition described herein and a pharmaceutically acceptable excipient, methods for treating cancer in a patient in need thereof, the method comprising administering to the patient one or more composition described herein, and methods for preparing the compositions described herein. | 2022-01-06 |
20220002228 | COMPOUNDS FOR USE IN THE TREATMENT OR PROPHYLAXIS OF PAIN, INFLAMMATION AND/OR AUTOIMMUNITY - The present invention relates to a polymorphic form of (S,S)-2-N(3-O-(propan-2-ol)-1-propyl-4-hydroxybenzene)-3-phenylpropylamide or synonymously named N-[2-(4-Hydroxy-phenyl)-(2-hydroxy-propoxymethyl)-ethyl]-3-phenyl-propionamide and to the treatment or prophylaxis of pain, inflammation and/or autoimmunity and provides a method of treating or preventing pain, inflammation and/or autoimmunity as well as the use of this polymorphic form in the manufacture of medicaments for the treatment or prophylaxis of pain (preferably nociceptive or neuropathic), inflammation and/or autoimmunity in humans and/or non-human animals. | 2022-01-06 |
20220002229 | DIGLYCOLAMIDE DERIVATIVES FOR SEPARATION AND RECOVERY OF RARE EARTH ELEMENTS FROM AQUEOUS SOLUTIONS - Rare earth extractant compounds having the following structure: | 2022-01-06 |
20220002230 | COMPOUND CONTAINING DIPHENYLMETHANE STRUCTURE AND USE THEREOF - A structure of the compound containing a diphenylmethane structure of the present invention is represented by General Formula (1). The compound containing a diphenylmethane structure of the present invention contains a hydroxyl group, an amino group, a substituted amino group, and an active group, and can be used as an amino acid or peptide C-terminal protection reagent. A peptide synthesis reaction using this protection carrier has a fast reaction speed and a high reagent utilization rate in a suitable solvent system; post-treatment is carried out by means of simple liquid-liquid extraction separation, i.e. effective purification can be carried out, and finally, a product with a high purity can be obtained; and during a synthesis process, the change in solubility is small and an operation process has a strong universality, and therefore, the present method can be developed into a universal production method. | 2022-01-06 |
20220002231 | PARG INHIBITORS AND METHOD OF USE THEREOF - Provided herein are, inter alia, compounds inhibiting poly(ADP-ribose) Glycohydrolase (PARG) in a cancer cell and methods of treating cancer using compounds of the invention. | 2022-01-06 |
20220002232 | PROCESS FOR THE PREPARATION OF 4,5-DIHYDROXY-2-(4-METHYLBENZYL)ISOPHTHALONITRILE - The present disclosure relates to a process for the preparation of 4,5-dihydroxy-2-(4-methylbenzyl)isophthalonitrile, to use of a compound which is 2-methoxy-5-(4-methylbenzyl)phenol, (3-hydroxy-4-methoxyphenyl)(p-tolyl)methanone, 2-methoxy-5-(4-methylbenzoyl)phenyl 2-chloroacetate, 4-methylbenzoyl chloride, 2-methoxyphenyl 2-chloroacetate or 2-methoxyphenol in the preparation of 4,5-dihydroxy-2-(4-methylbenzyl)isophthalonitrile and to a compound which is 4-hydroxy-5-methoxy-2-(4-methylbenzyl)isophthalaldehyde dioxime or 4-hydroxy-5-methoxy-2-(4-methylbenzyl)isophthalaldehyde and use thereof in the preparation of 4,5-dihydroxy-2-(4-methylbenzyl)isophthalonitrile. 4,5-Dihydroxy-2-(4-methylbenzyl)isophthalonitrile is a COMT inhibitor. | 2022-01-06 |
20220002233 | AMMOXIDATION CATALYST FOR PROPYLENE, MANUFACTURING METHOD OF THE SAME CATALYST, AMMOXIDATION METHOD USING THE SAME CATALYST - There are provided an ammoxidation catalyst for propylene, a manufacturing method of the same, and an ammoxidation method of propylene using the same. Specifically, according to one embodiment of the invention, there is provided a catalyst having a structure in which metal oxide is supported on a silica carrier, having narrow particle size distribution, and having excellent attrition loss. | 2022-01-06 |
20220002234 | PRODUCTION METHOD FOR ISOCYANATE COMPOUND - The objective of the present invention is to provide a method for producing an isocyanate compound safely and efficiently. The method for producing an isocyanate compound according to the present invention is characterized in comprising the steps of irradiating a high energy light to a halogenated methane at a temperature of 15° C. or lower in the presence of oxygen, and further adding a primary amine compound to be reacted without irradiating a high energy light. | 2022-01-06 |
20220002235 | METHOD FOR PREPARING ISOPHORONE DIISOCYANATE - A method for preparing isophorone diisocyanate by (1) reacting isophorone with hydrogen cyanide in the presence of a catalyst to obtain isophorone nitrile; (2) reacting the isophorone nitrile obtained in step (1) with ammonia gas and hydrogen in the presence of a catalyst to obtain isophorone diamine; and (3) subjecting the isophorone diamine to a phosgenation reaction to obtain the isophorone diisocyanate, wherein the content of impurities containing a secondary amine group in the isophorone diamine that undergoes the phosgenation reaction in step (3) is ≤0.5 wt. The method reduces the content of hydrolyzed chlorine in the isophorone diisocyanate product, improves the yellowing resistance of the product, and the harm due to presence of hydrolyzed chlorine in the product is reduced. | 2022-01-06 |
20220002236 | The method for preparing dicarbamate compounds from diamines and the catalyst thereof - The present invention relates to a method of directly preparing a dicarbamate compound from a diamine compound, and more particularly to a method of directly preparing a dicarbamate compound by reacting a diamine compound with an alcohol compound in the presence of a mixed gas of carbon monoxide (CO) and oxygen (O | 2022-01-06 |
20220002237 | METHOD FOR CONVERTING MONOISOCYANATES TO UREAS - Organic isocyanates are converted to ureas by heating in the presence of certain cobalt, magnesium, chromium and lanthanide series organometallic catalysts. The process requires no water or other reactants. The process is particularly useful for removing small quantities of monoisocyanates from a solvent stream recovered from a polyisocyanate manufacturing process. The urea compounds in some instances can be recycled back into the polyisocyanate manufacturing process and reacted with polyisocyanate compounds to form biurets. | 2022-01-06 |
20220002239 | A CRYSTALLINE FORM OF 3- ((L-VALYL) AMINO) -1-PROPANESULFONIC ACID - The present invention relates to a crystalline form of compound | 2022-01-06 |
20220002240 | SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF - Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorder | 2022-01-06 |
20220002241 | PROCESS FOR THE PREPARATION OF ARYLSULFONYLPROPENENITRILES - The present invention relates to a process for the preparation of arylsulfonylpro-penenitriles. The reaction starting from arylsulfonyl halides is catalyzed by a cat-alyst compound comprising a transition metal. The process is scalable, environ-mentally benign and provides the product in good yield. | 2022-01-06 |
20220002242 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF - Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed. | 2022-01-06 |
20220002243 | NOVEL CELL METABOLISM MODULATING COMPOUNDS AND USES THEREOF - A novel class of compounds according to Formula I, II, or III, wherein W | 2022-01-06 |
20220002244 | CRYSTALLINE L-ARGININE SALT OF (R)-2-(7-(4-CYCLOPENTYL-3- (TRIFLUOROMETHYL)BENZYLOXY)-1,2,3, 4-TETRAHYDROCYCLO-PENTA [B]INDOL-3-YL)ACETIC ACID(COMPOUND1) FOR USE IN SIPI RECEPTOR-ASSOCIATED DISORDERS - The present invention relates to, inter alia, a novel crystalline free-plate habit or morphology, processes for preparing the crystalline free-plate habit, and uses of the crystalline free-plate habit of the L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid (Compound 1) in the treatment of S1P | 2022-01-06 |
20220002245 | CRYSTALLINE FORM OF N-BUTYLDEOXYGALACTONOJIRIMYCIN - The invention relates to a crystalline form of [(2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)-piperidine-3,4,5-triol, processes for the preparation thereof, pharmaceutical compositions containing such a crystalline form, and its use as a medicament, especially as glycolipid biosynthesis inhibitor. | 2022-01-06 |
20220002246 | COMPOUNDS AS NEUROKININ-1 RECEPTOR ANTAGONISTS AND USES THEREOF - The present invention relates compounds of Formula (A) as NK-1 receptor antagonists, as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of dysfunctional glutamate transmission. The present invention also relates to the uses of the compounds or pharmaceutical compositions in treating or preventing certain disorders and diseases which relate to NK-1 receptor in humans. More specifically, the compounds and/or pharmaceutical compositions of the present invention are believed to potentially offer therapeutic benefits to patients who suffer, among others, chemotherapy-induced nausea and vomit (CINV) and/or post-operative nausea and vomit (PONV). | 2022-01-06 |
20220002247 | Process for producing substituted amino alcohols - A process for producing a compound of the formula (T) | 2022-01-06 |
20220002248 | MDM2 INHIBITOR, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF - The present invention relates to an MDM2 inhibitor, a preparation method therefor, a pharmaceutical composition thereof, and the use thereof. Specifically, the present invention relates to a compound represented by formula I. The compound has excellent MDM2 inhibitory activities, and can be used for preparing a pharmaceutical composition for treating cancers and other diseases related to MDM2 activities, particularly p53 wild-type cancer. | 2022-01-06 |
20220002249 | METHOD FOR PREPARING 2,3-DICHLORO-5-TRIFLUOROMETHYLPYRIDINE WITH HIGH SELECTIVITY - A method for preparing 2,3-dichloro-5-trifluoromethylpyridine, comprising at a temperature of 100˜150° C. and a pressure of 0.5˜5.0 MP, in presence of at least one catalyst selected from supported metal chloride, supported zeolite molecular sieve and supported heteropolyacid, 2-chloro-5-trifluoromethylpyridine reacts with chlorine gas to obtain 2,3-dichloro-5-trifluoromethylpyridine. The preparing method provided by the present invention has advantages such as high selectivity of desired product, high utilization rate of chlorine gas, moderate process condition, simple operation and less three wastes. The present invention also discloses a preparing method for preparing 2-chloro-5-trifluoromethylpyridine, which is capable of reducing unit consumption, reducing separation cost, and improving safety compared to the prior art. | 2022-01-06 |
20220002250 | POLYMERIC METAL CHELATING COMPOSITIONS AND METHODS OF PREPARING SAME FOR CONTROLLING GROWTH AND ACTIVITIES OF LIVING CELLS AND ORGANISMS FOR THERAPEUTIC USE IN TREATING DISEASES IN ANIMALS, FISH OR HUMANS - Disclosed are chelating co-polymer compositions that are soluble in aqueous media and chelate essential metals, methods of preparation and uses thereof. The chelating compositions are comprised of two or more different monomers, at least one of which possesses metal binding or metal chelating activity. The chelating compositions are synthesized by reversible addition-fragmentation transfer (RAFT) polymerization with the aid of a suitable RAFT-mediating agent. Also described are chelating compositions that comprise hydroxypyridinone chelating groups. The ability of the chelating compositions to bind metals affects the activity of a living cells and organisms, which require the metals for cellular functions. | 2022-01-06 |
20220002251 | HUMAN TLR8-SELECTIVE AGONISTS - The disclosure provides human toll-like receptor modulators of general Formula (II), wherein R | 2022-01-06 |
20220002252 | SUCCINATE DEHYDROGENASE INHIBITORS AND METHODS OF MAKING AND USING THE SAME - Provided herein are compounds of Formula (I), including methods of making the same. The disclosed compounds are succinate dehydrogenase inhibitors and can be useful in, e.g., inhibiting or preventing fungal growth. | 2022-01-06 |
20220002253 | METHOD FOR PRODUCING OROTIC ACID DERIVATIVE - Provided is a method for producing an orotic acid derivative, the method comprising a condensation step of performing, under a basic condition, a condensation reaction between an orotic acid halide represented by General Formula (I) and a compound represented by General Formula (II) to generate an orotic acid derivative represented by General Formula (III); and a neutralization crystallization step of precipitating crystals of orotic acid by neutralization crystallization to separate a liquid containing the orotic acid derivative from the crystals of orotic acid, after the condensation step. In General Formula (I), (II), or (III), X is a halogen atom, and A is a group represented by General Formula (A-1) or (A-2). In General Formula (A-1) or (A-2), R | 2022-01-06 |
20220002254 | ANODIC OXIDATION OF 5-AMINOURACIL - A process for preparing pyrimido[4,5-g]pteridine-2,4,7,9-tetraol, or a salt thereof, is provided. A process for the preparation of 3,6-diaminopyrazine-2,5-dicarboxylic acid, or a salt thereof, from pyrimido[4,5-g]pteridine-2,4,7,9-tetraol, or a salt thereof, is further provided. A process for preparing a substituted pteridine compound, or a salt thereof, is further provided. A process for the preparation of a N-substituted 3,6-diaminopyrazine-2,5-dicarboxylic acid from a substituted pteridine compound, or a salt thereof, is further provided. | 2022-01-06 |
20220002255 | UBE2K MODULATORS AND METHODS FOR THEIR USE - Provided are compounds of Formula (I): | 2022-01-06 |
20220002256 | TRIAZINANES AND METHODS OF MAKING THEM - The present invention is directed to compounds represented by the formula: Formula (i) wherein R | 2022-01-06 |
20220002257 | PRODUCTION METHOD FOR HEMIAMINAL COMPOUND AND PRODUCTION METHOD FOR HETEROCYCLIC COMPOUND - In a production method for a hemiaminal compound, a compound represented by Formula (1), a compound represented by Formula (2), and an oxidizing agent are mixed. A hemiaminal compound represented by Formula (3) is obtained. In a production method for a heterocyclic compound, a hemiaminal compound is mixed with a base. | 2022-01-06 |
20220002258 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF FLUENSULFONE - The invention provides a process for preparing heterocyclic fluoroalkenyl sulfones and their thioether and sulfoxide precursors of the formula: Cl—R—S(O) | 2022-01-06 |
20220002259 | CONTINUOUS ISOLATION OF CANNABIDIOL AND CONVERSION OF CANNABIDIOL TO DELTA 8-TETRAHYDROCANNABINOL AND DELTA 9-TETRAHYDROCANNABINOL - In alternative embodiments, provided are processes comprising the continuous isolation and purification of cannabinoids and further isomerization of the purified cannabidiol to Δ | 2022-01-06 |
20220002260 | PREPARATION OF 2-SUBSTITUTED 4-METHYL-TETRAHYDROPYRANS FROM 2-SUBSTITUTED 4-HYDROXY-4-METHYL-TETRAHYDROPYRANS AS STARTING MATERIALS - The present invention relates to a method for preparing 2-substituted 4-methyltetrahydropyrans from 2-substituted 4-hydroxy-4-methyltetrahydropyrans as starting materials. | 2022-01-06 |
20220002261 | SYNTHESIS AND PURIFICATION OF CANNABINOL FROM CANNABIDIOL - A method to prepare cannabinol (CBN) from derived cannabidiol (CBD) is disclosed. The CBD can be derived from hemp and reacted with a halogen, leading to the cyclization and aromatization of CBD to CBN. The removal of halogen is improved via selective solvent exchange. CBN is isolated from the reaction mixture by use of orthogonal chromatography techniques to provide CBN of high purity. | 2022-01-06 |
20220002262 | METHOD OF PRODUCING PERFLUORO(2-METHYLENE-4-METHYL-1,3-DIOXOLANE) - Provided is a method of producing perfluoro(2-methylene-4-methyl-1,3-dioxolane), the method including at least following processes (1) to (3):
| 2022-01-06 |
20220002263 | REAGENTS AND PROCESS FOR DIRECT C-H FUNCTIONALIZATION - The present invention refers to a process for direct C—H functionalization, the reagents used in the process and the use thereof for the direct C—H functionalization as well as the so-obtained products. | 2022-01-06 |
20220002264 | PHARMACEUTICAL COMPOUNDS - The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy. | 2022-01-06 |
20220002265 | RHO KINASE INHIBITOR, METHOD FOR PREPARING SAME AND USES THEREOF - Provided are a Rho kinase inhibitor, a method for preparing same and the uses thereof. The Rho kinase inhibitor designates a compound of Formula I, a stereoisomer thereof or pharmaceutically acceptable salt thereof. The Rho kinase inhibitor promotes endothelial cells and endothelin expression, prostenin expression, and vascular factors NO synthesis and secretion, has a promoting effect on proprostin expression independently of the doses used, shows lower toxicity, while being safer. | 2022-01-06 |
20220002266 | RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF - A Rho-associated protein kinase (ROCK) inhibitor represented by formula (I), a pharmaceutical composition comprising same, and a use thereof for preventing or treating ROCK-mediated diseases. | 2022-01-06 |
20220002267 | TYROSINE KINASE 2 INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF - Compounds of formula (I) useful as tyrosine kinase 2 (Tyk2) inhibitors, pharmaceutical compositions containing these compounds, methods of using the pharmaceutical compositions in the treatment of various disorders related to the regulation of Tyk2 activity, and methods of preparing these compounds are disclosed. | 2022-01-06 |
20220002268 | NOVEL HETEROARYL-TRIAZOLE AND HETEROARYL-TETRAZOLE COMPOUNDS AS PESTICIDES - The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements Y, Q | 2022-01-06 |
20220002269 | NOVEL COMPOUNDS FOR THE TREATMENT OF RESPIRATORY DISEASES - The present invention relates to new compounds that are useful in the prevention or treatment of respiratory diseases, such as asthma, acute and chronic inflammatory conditions, and fibrotic diseases or conditions in which fibrosis contributes to the pathology of the condition. The invention also relates to the preparation of the compounds, and to compositions including the compounds. The present invention also relates to the use of the compounds, as well as compositions including the compounds, in treating or preventing respiratory diseases, acute and chronic inflammatory conditions, and fibrotic diseases or conditions in which fibrosis contributes to the pathology of the condition. | 2022-01-06 |
20220002270 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS - The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds. | 2022-01-06 |
20220002271 | HETEROCYCLIC INHIBITORS OF PCSK9 - This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, PCSK9, or a pharmaceutically acceptable salt, solvate, prodrug or polymorph thereof, and to compositions and formulations comprising such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I): | 2022-01-06 |
20220002272 | BISARYL LACTAMS AS NRF2 ACTIVATORS - The present invention relates to bisaryl lactam compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the compounds of this invention include a compound of Formula (I): | 2022-01-06 |
20220002273 | CEREBLON BINDING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH - Provided herein are piperidine dione compounds having the following structure: | 2022-01-06 |
20220002274 | 3,4,5-Trisubstituted-1,2,4-Triazoles and 3,4,5-Trisubstituted-3-Thio-1,2,4-Triazoles and Uses Thereof - The present disclosure describes novel compounds that are somatostatin receptor type 4 agonists. | 2022-01-06 |
20220002275 | ENZYME INHIBITORS - The present invention provides a selection of compounds of formula (I): | 2022-01-06 |
20220002276 | PYRIDIN-SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF CONDITIONS RELATED TO INTERLEUKIN 1 BETA - The present invention relates to a novel class of pyridine-sulfonamide compounds and to compositions comprising the same. The compounds and compositions are useful as medicaments in the treatment of diseases responsive to inhibition of IL-1β, such as non-alcoholic steatohepatitis (NASH) and idiopathic pulmonary fibrosis (IPF). | 2022-01-06 |
20220002277 | PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYLMETHYL GROUP - It is intended to provide a novel compound or a salt thereof, or crystals of the compound or the salt, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl. | 2022-01-06 |
20220002278 | HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF - Disclosed is a histone acetyltransferase (HAT) inhibitor. Provided are a compound represented by the general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereoisomer, an atropisomer, a racemate, a polymorph, a solvate or an isotope-labeled compound (including deuterium substitution) thereof, a preparation method therefor, a pharmaceutical composition comprising same and use thereof in the treatment of various HAT-related diseases or conditions. | 2022-01-06 |
20220002279 | NOVEL IMIDAZOLE DERIVATIVE - The present invention provides a new imidazole derivative represented by the following formula or a pharmaceutically acceptable salt thereof which exhibits potent antimicrobial activity based on a LpxC-inhibiting action against gram-negative bacteria such as | 2022-01-06 |
20220002280 | COMPOUNDS AND METHODS OF USE - This present disclosure relates to compounds with ferroptosis inducing activity, a method of treating a subject with cancer with the compounds, and combination treatments with a second therapeutic agent. | 2022-01-06 |
20220002281 | PYRROLIDINONE DERIVATIVES AS FORMYL PEPTIDE 2 RECEPTOR AGONISTS - The disclosure relates to compounds of formula (I), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, and related diseases. | 2022-01-06 |
20220002282 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES - Compounds represented by the structural formula (1) R1, R2, R3, R4, R5, R6 are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases. | 2022-01-06 |
20220002283 | MELOXICAM CO-CRYSTALS - Co-crystals of meloxicam co-formers can be prepared by co-crystallization from a polar solvent, such as aqueous dimethyl sulfoxide; or by slurry processes, such as with ethyl acetate. Such co-crystals have improved purities and are physically stable under storage for several months. | 2022-01-06 |
20220002284 | PESTICIDAL COMPOUNDS - The present invention relates to the compounds of formula (I), and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein the variables are defined according to description formula (I). The compounds of formula (I), as well as the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof, are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds. | 2022-01-06 |
20220002285 | STABLE HEAVY ISOTOPES IN AMIDE FUNCTIONAL GROUPS AND USES THEREOF - There are provided isotope-enriched compounds containing stable heavy isotope-enriched amide functional groups for modulating the pharmacokinetic profile, metabolic profile, and/or delivery efficiency of a drug or prodrug, as well as its therapeutic or prophylactic efficacy and/or adverse effects. Use of the isotope-enriched amide-containing drugs and prodrugs for the treatment or prevention of disease states and conditions is also provided. | 2022-01-06 |
20220002286 | THERAPEUTIC COMPOUNDS - The present invention relates to compounds that are Nrf2 activators. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with Nrf2 activation. | 2022-01-06 |
20220002287 | INDAZOLE KINASE INHIBITOR AND USE THEREOF - The present invention relates to a kinase inhibitor, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention further relates to pharmaceutical compositions comprising the kinase inhibitor, as well as to using said compounds and compositions to inhibit cKIT (especially mutant cKIT/T670I), FLT3 (comprising mutant FLT3-ITD), PDGF | 2022-01-06 |
20220002288 | MONOBACTAM COMPOUNDS AND USE THEREFOR - Monobactam compounds and a use therefor. Specifically provided are chemical compounds represented by formula (I) or isomers, pharmaceutically acceptable salts, solvates, crystals, or prodrugs thereof, preparation methods therefor, pharmaceutical compositions containing said compounds, and a use of said compounds or compositions in treating bacterial infection. The present compounds feature excellent antibacterial activity, and have great hopes of becoming a therapeutic agent for bacterial infection. | 2022-01-06 |
20220002289 | NEW DIHYDROQUINAZOLINONES EXHIBITING PROTECTIVE ACTIVITY AGAINST INTRACELLULAR-ACTING TOXINS, INTRACELLULAR VIRUSES AND BACTERIA - The invention relates to a new family of compounds of the type 2,3-dihydroquinazolin-4(1H)-one and the use thereof as inhibitors of the toxic effects of intracellular-acting toxins, such as ricin, Shiga toxins or the cholera toxin, using retrograde transport to intoxicate the cells, or viruses or bacteria using retrograde and/or syntaxin 5-dependent transport to infect the cells, specifically viruses or bacteria entering into the cells by means of endocytosis, or intracellular parasites. | 2022-01-06 |
20220002290 | TRIFLUOROMETHYL-SUBSTITUTED SULFONAMIDE AS BCL-2-SELECTIVE INHIBITOR - Disclosed is a trifluoromethyl-substituted sulfonamide BCL-2-selective inhibitor, in particular disclosed are a compound of formula I, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition thereof. Also disclosed are the uses of said compound and of a pharmaceutical composition comprising same for treating anti-apoptotic BCL-2-related diseases, such as cancer. | 2022-01-06 |
20220002291 | PROTEOLYSIS-TARGETING CHIMERAS - The present disclosure provides compounds of the formula (I) wherein these compounds contain a ligand which binds to one or more target proteins such as CDK4 or CDK6 and a ligand which binds to the machinery associated with the ubiquitinating protein machinery. Also provided herein are methods of using these compounds in compositions or methods of treating patients with these compounds for the treatment of a disease or disorders such as cancer. | 2022-01-06 |
20220002292 | CRYSTALLINE FORMS OF A SUBSTITUTED IMIDAZOPYRIDINE COMPOUND AND USE THEREOF AS P2X3 MODULATOR - Described herein are crystalline forms of a P2X3 modulator, namely (S)-methyl-2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl-7-methylimidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate or a solvate thereof, and use thereof for treating pain, urinary tract disorder, cough, pruritus and endometriosis. | 2022-01-06 |
20220002293 | 8-CYCLOPENTYL-7-OXO-2-(4-PIPERAZIN-1-YL-PHENYLAMINO)-7, 8-DIHYDRO-PYRIDO [2,3-D]PYRIMIDINE-6-CARBONITRILE AND USES THEREOF IN TREATING PROLIFERATIVE DISORDERS - The novel compound 8-Cyclopentyl-7-oxo-2-(4-piperazin-1-yl-phenylamino)-7,8-dihydro-pyrido[2,3- | 2022-01-06 |
20220002294 | ERK INHIBITORS AND USES THEREOF - The present disclosure provides compounds and compositions that are inhibitors of ERK1, ERK2, or both, and methods of use thereof. | 2022-01-06 |
20220002295 | HETEROCYCLIC COMPOUNDS AND MEDICAL USE THEREOF - The present invention relates to heterocyclic nitrogen compounds, use thereof as a medicament and pharmaceutical compositions thereof. Furthermore, the invention provides combinations of compounds of general formula (I) with therapeutic agents, such as correctors, potentiators and amplifiers of dysfunctional proteins. | 2022-01-06 |
20220002296 | PHARMACEUTICAL COMPOUNDS AND THERAPEUTIC METHODS - The invention provides compounds of formula (16) and (17); and salts thereof, as well as compositions comprising such compounds and salts, complexes comprising such compounds and salts, and methods for treating cancer, inhibiting BMI1 expression, or treating Huntington's disease using such compounds, salts, and complexes. The compounds, salts, and complexes have potency, permeability, and oral bioavailability that make them particularly useful, for example, for the treatment of glioblastoma. | 2022-01-06 |
20220002297 | POLYMORPHS OF X842 - The present invention relates to polymorphs of 5-{2-[({8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-yl}carbonyl)-amino]ethoxy}-5-oxopentanoic acid (X842), more specifically forms A and B of X842. The invention also relates to a process for the preparation of these polymorphs, to pharmaceutical compositions comprising such polymorphs, and to methods for treating or preventing a gastrointestinal inflammatory disease or a gastric acid related disease, comprising administering a pharmaceutical composition comprising such polymorphs. | 2022-01-06 |
20220002298 | KRAS G12C INHIBITORS AND METHODS OF USING THE SAME - Provided herein are KRAS G12C inhibitors, such as | 2022-01-06 |
20220002299 | TRICYCLIC PYRIDONE COMPOUNDS AS JAK2 V617F INHIBITORS - The present application provides tricyclic pyridone compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer. | 2022-01-06 |
20220002300 | PHARMACOPHORE FOR TRAIL INDUCTION - There are disclosed imidazolinopyrimidinone compounds that have activity to induce TRAIL gene expression in macrophages. There is further disclosed a method for treating various cancers comprising administering effective amounts of an imidazolinopyrimidinone having the structure of Formula I herein. | 2022-01-06 |
20220002301 | AMINOPYRIMIDINYL DERIVATIVES - A compound of formula I: | 2022-01-06 |
20220002302 | NOVEL POLYMORPHS OF ACALABRUTINIB, A BRUTON'S TYROSINE KINASE INHIBITOR - The present invention discloses novel crystalline polymorphic forms of Acalabrutinib, methods of preparation, pharmaceutical compositions and methods of therapeutic treatment involving polymorphic forms thereof. | 2022-01-06 |
20220002303 | DIHYDROPYRROLOPYRAZOLE DERIVATIVE - The present invention provides a compound represented by general formula (I) or a pharmacologically acceptable salt thereof. [In the formula, the two Rs each independently represents a C | 2022-01-06 |
20220002304 | PROCESSES FOR MAKING SERD TRICYCLIC COMPOUNDS HAVING A SUBSTITUTED PHENYL OR PYRIDINYL MOIETY - Provided herein are processes for the preparation of compounds useful in the treatment of cancer. | 2022-01-06 |
20220002305 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CDK9 ACTIVITY - Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I): | 2022-01-06 |
20220002306 | CRYSTAL FORM OF UPADACITINIB AND PREPARATION METHOD AND USE THEREOF - The present disclosure relates to a crystalline form of upadacitinib and processes for preparation thereof. The present disclosure also relates to a pharmaceutical composition containing the crystalline form, use of the crystalline form for preparing a JAK inhibitor drug, and use of the crystalline form for preparing drugs treating rheumatoid arthritis. The crystalline form of upadacitinib provided by the present disclosure has one or more improved properties compared with prior art and has significant values for future drug optimization and development. | 2022-01-06 |