02nd week of 2012 patent applcation highlights part 38 |
Patent application number | Title | Published |
20120009499 | COMPRESSION ARRANGEMENT FOR FUEL OR ELECTROLYSIS CELLS IN A FUEL CELL STACK OR AN ELECTROLYSIS CELL STACK - A fuel cell stack or an electrolysis cell stack comprises a plurality of cells, which need to be compressed to ensure and maintain internal contact. To achieve an evenly distributed compression force throughout the electrochemically active area a frame with a central aperture is positioned on top of the cell stack between a resilient plate and a top plate. The enclosed aperture forms a compression chamber which is provided with pressurised gas from the cathode inlet, whereby an evenly distributed force is applied to the electrochemically area of the cell stack by the resilient plate. | 2012-01-12 |
20120009500 | SELECTIVELY SEALING FUEL CELL POROUS PLATE - A method of manufacturing a porous structure for a fuel cell is disclosed. The method includes providing the porous structure, and processing the porous structure to selectively produce a non-porous region on the porous structure. In one example, the non-porous region is provided at the perimeter of the porous structure, an edge of an internal manifold and/or a surface or recess that supports a seal or gasket. The non-porous region has a porosity that is less than the porosity of the porous structure. The non-porous region prevents undesired leakage of fluid from the porous structure and prevents migration of adhesive associated with the seals. | 2012-01-12 |
20120009501 | METHODS OF MANUFACTURING PROTON CONDUCTIVE SOLID OXIDE FUEL CELL AND PROTON CONDUCTIVE SOLID OXIDE FUEL CELLS MANUFACTURED BY USING THE METHODS - A method of manufacturing a proton conductive solid oxide fuel cell, the method including: forming a metallic mask layer having nanoholes on a first surface of a substrate; selectively etching the first surface of the substrate using the metallic mask layer; depositing a first membrane electrode assembly (MEA) member on the etched first surface of the substrate; etching an opposing second surface of the substrate; and forming second and third MEA members on the first MEA member. | 2012-01-12 |
20120009502 | FUEL CELL AND FLOW FIELD PLATE WITH FLOW GUIDE - A flow field plate for use in a fuel cell includes a non-porous plate body having a flow field. The flow field includes a plurality of channels and a flow distribution portion adjacent an end of the plurality of channels for distributing fluid between a manifold and the channels. A flow guide within the flow distribution portion establishes a desired flow distribution between the manifold and the plurality of channels. | 2012-01-12 |
20120009503 | FUEL CELL ELECTRODES WITH CONDUCTION NETWORKS - A fuel cell electrode layer may include a catalyst, an electronic conductor, and an ionic conductor. Within the electrode layer are a plurality of electronic conductor rich networks and a plurality of ionic conductor rich networks that are interspersed with the electronic conductor rich networks. A volume ratio of the ionic conductor to the electronic conductor is greater in the ionic conductor rich networks than in the electronic conductor rich networks. During operation of a fuel cell that includes the electrode layer, conduction of electrons occurs predominantly within the electronic conductor rich networks and conduction of ions occurs predominantly within the ionic conductor rich networks. | 2012-01-12 |
20120009504 | ELECTRODES FOR FUEL CELLS - A method comprises creating an electrode by depositing alternating first and second layers on a substrate, and using the electrode to make a solid oxide fuel cell. The first layer comprises a metal, and the second layer comprises a non-metal, for example a ceramic material. The substrate may be moved between a first region containing the metal and substantially free of the non-metal, and a second region containing the non-metal and substantially free of the metal. The composition of the metal and/or the non-metal may be varied along the thickness of the layers. The deposited layers may be heated. A fuel cell may have a fuel cell electrode that comprises a substrate, and alternating first and second layers deposited on the substrate, where the first layer includes a metal and the second layer includes a non-metal. The fuel cell may be a solid oxide fuel cell. | 2012-01-12 |
20120009505 | ANISOTROPIC CTE LSM FOR SOFC CATHODE - An anisotropic coefficient of thermal expansion (CTE) cathode of a solid oxide fuel cell (SOFC) is formed by placing a layer of perovskite powder between two platens, and sintering the layer while applying pressure to the platens, thereby forming the anisotropic CTE cathode. The perovskite can be lanthanum strontium manganite (LSM). | 2012-01-12 |
20120009506 | MANUFACTURING METHOD OF CELL ASSEMBLY FOR FUEL CELL AND MANUFACTURING METHOD OF FUEL CELL - A manufacturing method of a cell assembly for a fuel cell includes: producing an electrode member, a separator, and a seal member preform, which has a frame shape and which is formed from an uncrosslinked item of solid rubber having adhesiveness, in a predetermined shape in advance; arranging the electrode member, the separator, and the seal member preform in a forming die including a pressing member, and closing the forming die while the pressing member is pressing a side of the electrode member that is opposite to the separator in the thickness direction; and pressurizing and heating the forming die to crosslink the uncrosslinked item so that the seal member seals the peripheral edge portion of the electrode member and integrates the electrode member and the separator with each other. | 2012-01-12 |
20120009507 | PRECONDITIONING TREATMENT TO ENHANCE REDOX TOLERANCE OF SOLID OXIDE FUEL CELLS - A high temperature, redox tolerant fuel cell anode electrode and method of fabrication in which the anode electrode is pre-conditioned by application of an initial controlled redox cycle to the electrode whereby an initial re-oxidation of the anode electrode is carried out at temperatures less than or equal to about 650° C. | 2012-01-12 |
20120009508 | LASER MARKING HOLOGRAM HAVING A VOLUME HOLOGRAM WITH INTERFERENCE FRINGES USING SELECTIVE IRRADIATION - The present invention is provided to enhance security of a volume hologram by recording therein individualized information such as information of character, numerical character, picture pattern, biometric matter and/or the like by irradiating laser light to the volume hologram thereby modifying the same physically or chemically, and is related to a laser marking hologram comprising a volume hologram layer | 2012-01-12 |
20120009509 | GENERATION METHOD, CREATION METHOD, EXPOSURE METHOD, DEVICE FABRICATION METHOD, STORAGE MEDIUM, AND GENERATION APPARATUS - The present invention provides a generation method that obtains a position at which an auxiliary pattern is to be placed and generates a mask pattern (its data), which achieves excellent imaging performance, even when a halftone mask is used as an original. | 2012-01-12 |
20120009510 | LITHOGRAPHY MASK AND METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE - A lithography mask is disclosed. The lithography mask is for use with an exposure apparatus which forms an unpatterned first region and a patterned second region that includes groups of desired patterns in a photosensitive layer. The lithography mask includes a transparent substrate; and a patterned light blocking layer that is formed above the transparent substrate and that is configured to block or partially transmit incident light. The patterned light blocking layer includes a first mask pattern that exposes the first region. The first mask pattern includes a periodic pattern having a sub-resolution pitch that is given by an exposure condition of the exposure apparatus. | 2012-01-12 |
20120009511 | METHOD AND APPARATUS FOR CORRECTING ERRORS OF A PHOTOLITHOGRAPHIC MASK - A method for correcting a plurality of errors of a photolithographic mask, comprising optimizing first parameters of a imaging transformation of the photolithographic mask and second parameters of a laser beam locally directed onto the photolithographic mask, and correcting the plurality of errors by applying an imaging transformation using optimized first parameters and locally directing the laser beam onto the photolithographic mask using optimized second parameters, wherein the first and the second parameters are simultaneously optimized in a joint optimization process. | 2012-01-12 |
20120009512 | EXTREME ULTRAVIOLET PHOTOMASK - A method of manufacturing a photomask includes forming an upper layer on a photomask substrate, and patterning the upper layer to form an upper pattern having an inclined sidewall, wherein patterning the upper layer includes anisotropically etching the upper layer using charged particles moving in parallel to a first direction inclined toward a top surface of the upper layer. | 2012-01-12 |
20120009513 | ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE - To provide an electrophotographic photoconductor, containing: a conductive support; a photosensitive layer provided above the conductive support; and a hardened protective layer provided above the photosensitive layer, wherein the hardened protective layer contains a hardened product of a radical polymerizable compound containing an adamantane skeleton. | 2012-01-12 |
20120009514 | IMAGE FORMING METHOD, TWO-COMPONENT DEVELOPER, IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE - In the image forming method, at least one color toner image and a transparent toner image are formed using a color developer including a color toner and a carrier and contained in a first developing device, and a second developer including a transparent toner and a carrier and contained in a second developing device. A supplementary developer is supplied at least to the second developing device while discharging excess of the developer in the developing device. The transparent toner includes a lubricant and has a viscoelastic property such that a loss tangent (tan δ), which is defined as a ratio (G″/G′) of loss modulus (G″) to storage modulus (G′), has a peak at a temperature of from 80° C. to 160° C. and the peak has a height of not less than 3. | 2012-01-12 |
20120009515 | DEVELOPER FOR ELECTROPHOTOGRAPHY - The present invention provides a developer for electrophotography which is superior in property of build up of electrification and in charge stability even in environments of high temperature and high humidity or in an environment of low temperature and low humidity where it is difficult for a developer to retain its electrostatic charge performance, and which can provide an image free from fogging and decrease in density for a long term, that is, a developer for electrophotography containing composite oxide particles which include metal titanate particles containing titanium as a first metal atom and a second metal atom and containing therein 0.009 to 0.350% by weight of a third metal atom selected from the group consisting of the metal atoms belonging to Group 5A of the long form of the periodic table of elements. | 2012-01-12 |
20120009516 | ELECTROPHOTOGRAPHIC INK - The present disclosure provides inks, systems, and methods directed towards dispersed pigments. In one embodiment, an electrophotographic ink can comprise an aliphatic solvent and a pigment having a surface comprising carbonyl groups stabilized by an amine dispersant having the structure: R | 2012-01-12 |
20120009517 | ELECTROPHOTOGRAPHIC INK - The present disclosure provides inks, systems, and methods directed towards polyurethane encapsulated pigments. In one embodiment, an electrophotographic ink can comprise an electrophotographic ink vehicle and a polyurethane encapsulated pigment. The polyurethane encapsulated pigment can comprise a pigment and a polyurethane, wherein the polyurethane fully encapsulates the pigment and forms the outer-surface of the polyurethane encapsulated pigment with a surface roughness of less than 100 nm. Additionally, the electrophotographic ink can have a residual monomer content of less than 0.01 wt % of the electrophotographic ink. | 2012-01-12 |
20120009518 | DEVELOPING DEVICE, IMAGE FORMING METHOD AND APPARATUS, AND PROCESS CARTRIDGE - In the image forming method, a color toner image and a transparent toner image are formed using a first developing device containing a first developer including color toner and carrier, and a second developing device containing a second developer including transparent toner and carrier. At least the second developing device includes a developer bearing member bearing the second developer for developing an electrostatic image; a developer supplying passage supplying the developer to the developer bearing member while feeding the developer in a first direction; and a developer feeding passage separated from the developer supplying passage at a central portion thereof and feeding the developer used for development in a direction parallel to the first direction. The transparent toner includes a resin and a lubricant and has viscoelastic property such that loss tangent has a peak with height of not less than 3 at a temperature of from 80° C. to 160° C. | 2012-01-12 |
20120009519 | COMPOUND, RESIN AND PHOTORESIST COMPOSITION - The present invention provides a compound represented by the formula (I): | 2012-01-12 |
20120009520 | POSITIVE RESIST COMPOSITION AND METHOD OF FORMING RESIST PATTERN - A positive resist composition including a resin component (A1) having a structural unit (a1) derived from an acrylate ester which may have an atom other than hydrogen or a group bonded to the carbon atom on the α position and containing an acid dissociable, dissolution inhibiting group, and a structural unit (a0) containing an —SO | 2012-01-12 |
20120009521 | RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN, COMPOUND AND ACID GENERATOR - A resist composition including: a base component (A) which exhibits changed solubility in an alkali developing solution under action of acid; and an acid-generator component (B) which generates acid upon exposure, wherein said acid-generator component (B) comprises an acid generator (B1) including a compound represented by general formula (b1-11) shown below:
| 2012-01-12 |
20120009522 | ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION AND PATTERN FORMING METHOD USING THE SAME - An actinic ray-sensitive or radiation-sensitive resin composition, wherein when a film having a film thickness of 100 nm is formed from the actinic ray-sensitive or radiation-sensitive resin composition, the film has a transmittance of 55 to 80% for light at a wavelength of 193 nm, and a pattern forming method using the composition are provided. | 2012-01-12 |
20120009523 | METHOD FOR FORMING CONTACT HOLE OF SEMICONDUCTOR DEVICE - A method for forming a contact hole of a semiconductor device, includes forming a hard mask over an etch target layer, forming a first line pattern over the hard mask, forming a second line pattern over the hard mask and the first line pattern in a direction crossing the first line pattern, forming a mesh-type hard mask pattern by etching the hard mask using the first and second line patterns as etch barriers, and forming a contact hole by etching the etch target layer using the mesh-type hard mask pattern as an etch barrier. | 2012-01-12 |
20120009524 | MATERIAL AND METHOD FOR PHOTOLITHOGRAPHY - A photosensitive material for use in semiconductor manufacture comprises a copolymer that includes a plurality of photoresist chains and a plurality of hydrophobic chains, each hydrophobic chain attached to the end of one of the photoresist chains. The copolymer in response to externally applied energy will self-assemble to a photoresist layer and a hydrophobic layer. | 2012-01-12 |
20120009525 | Method and apparatus for printing a periodic pattern with a large depth of focus - A method for printing a desired pattern into a photosensitive layer that includes providing a mask bearing a pattern of linear features that are parallel to a first direction, arranging the layer parallel to and separated from said mask, generating substantially monochromatic light, and illuminating the mask pattern with said light over a range of angles of incidence in a plane parallel to said first direction, at substantially a single angle in an orthogonal plane of incidence and so that the light of each angle of incidence transmitted by the mask forms a light-field component at the layer whereby the integration of said components prints the desired pattern, wherein the range of angles is selected so that the integration of said components is substantially equivalent to an average of the range of transversal intensity distributions formed between Talbot image planes by light at one of the angles of incidence. | 2012-01-12 |
20120009526 | Method of Forming Fine Patterns - A method of forming fine patterns comprises forming a first auxiliary layer having an acid diffusion rate on an underlying layer, forming a light-transmitting second auxiliary layer having a slower acid diffusion rate than the first auxiliary layer on the first auxiliary layer, exposing respective regions of the first and second auxiliary layers to generate acid in the exposed regions of the first and second auxiliary layers, diffusing the acid using a baking process so that diffusion of the acid is faster in the first auxiliary layer than in the second auxiliary layer, removing acid diffusion regions in the first and second auxiliary layers to form first and second auxiliary patterns, the second auxiliary pattern being wider width than the first auxiliary pattern, filling the removed regions of the first auxiliary layer with material for a hard mask, and removing the material for a hard mask exposed between the second auxiliary patterns to form hard mask patterns on sidewalls of the first auxiliary patterns. | 2012-01-12 |
20120009527 | PATTERNING PROCESS - A pattern is formed by coating a resist composition comprising a polymer comprising recurring units having an acid labile group-substituted hydroxyl group and recurring units having an acid labile group-substituted carboxyl group, an acid generator, and an organic solvent onto a substrate, prebaking to form a resist film, exposing the resist film to high-energy radiation, PEB, and developing the exposed film two times with an organic solvent and an alkaline aqueous solution. Due to the two developments, one line is divided into two lines, achieving a resolution doubling the mask pattern. | 2012-01-12 |
20120009528 | COATING AND DEVELOPING APPARATUS AND METHOD - In one embodiment, a coating and developing apparatus includes a processing block including a vertical stack of early-stage processing unit blocks; a vertical stack of later-stage processing unit blocks disposed laterally adjacent to respective ones of the early-stage processing unit blocks; a vertical stack of developing unit blocks stacked on the early-stage processing unit blocks; a vertical stack of auxiliary processing unit blocks disposed laterally adjacent to respective ones of the developing unit blocks; first transfer units, each of which are disposed between the laterally adjacent early-stage processing unit and later-stage processing unit; second transfer units, each of which is disposed between the laterally adjacent developing unit block and auxiliary processing unit block; and a auxiliary transfer mechanism for transferring a substrate between the first transfer units and between the second transfer units. | 2012-01-12 |
20120009529 | PATTERNING PROCESS - A pattern is formed by applying a resist composition comprising a (meth)acrylate copolymer comprising both recurring units having an acid labile group-substituted carboxyl group and recurring units having a lactone ring, an acid generator, and an organic solvent onto a substrate, prebaking the composition to form a resist film, exposing the resist film to high-energy radiation, baking, and developing the exposed film with a developer. The developer comprises at least 40 wt % of an organic solvent selected from methyl benzoate, ethyl benzoate, phenyl acetate, benzyl acetate, methyl phenylacetate, benzyl formate, phenylethyl formate, methyl 3-phenylpropionate, benzyl propionate, ethyl phenylacetate, and 2-phenylethyl acetate. | 2012-01-12 |
20120009530 | Rotary Kilns for Alternative Fuels - A method for burning raw materials by which method the raw material and a secondary fuel are separately introduced to one and the same rotary kiln in which the raw material as well as the secondary fuel are heated by gases formed by burning of a primary fuel in the rotary kiln so that the secondary fuel is converted to gases and solid matter in the form of combustion residues such as ashes and coke. The secondary fuel during the process of conversion to gases and solid matter is kept separate from the introduced raw material, which may ensure that the secondary fuel and hence the locally reducing zones and major areas with reducing conditions are brought into minimum contact with the raw material. | 2012-01-12 |
20120009531 | DISTRIBUTED COMBUSTION PROCESS AND BURNER - During a heating phase, injection of a jet of fuel and oxidant (fuel annularly enshrouding oxidant or oxidant annularly enshrouding fuel) from a fuel-oxidant nozzle is combusted in a combustion space. During a transition from the heating phase to a distributed combustion phase, an amount of a secondary portion of either the fuel or oxidant is injected as a jet into the combustion space while the primary portion of that same reactant from the fuel-oxidant nozzle is decreased. At some point during the transition phase, a jet of actuating fluid is injected at an angle towards the jet of reactants from the fuel-oxidant nozzle and/or towards the jet of the secondary portion of reactant. The jet of primary portions of reactants and/or secondary portion of reactant is caused to be bent/deviated towards the other of the two jets. The staging of the secondary portion of reactant is increased until a desired degrees of staging and commencement of a distributed combustion phase are achieved. | 2012-01-12 |
20120009532 | DISTRIBUTED COMBUSTION PROCESS AND BURNER - During a heating phase, injection of a jet of fuel and oxidant (fuel annularly enshrouding oxidant or oxidant annularly enshrouding fuel) from a fuel-oxidant nozzle is combusted in a combustion space. During a transition from the heating phase to a distributed combustion phase, an amount of a secondary portion of either the fuel or oxidant is injected as a jet into the combustion space while the primary portion of that same reactant from the fuel-oxidant nozzle is decreased. At some point during the transition phase, a jet of actuating fluid is injected at an angle towards the jet of reactants from the fuel-oxidant nozzle and/or towards the jet of the secondary portion of reactant. The jet of primary portions of reactants and/or secondary portion of reactant is caused to be bent/deviated towards the other of the two jets. The staging of the secondary portion of reactant is increased until a desired degrees of staging and commencement of a distributed combustion phase are achieved. | 2012-01-12 |
20120009533 | MULTI-OUTPUT VALVE AND BURNER USEFUL TO PROMOTE NON-STATIONARY FLAME - A valve useful in distributing gas received in one inlet to several outlets in a sequence, and burner apparatus including this valve for feeding material in sequence to outlets of a burner thereby forming a non-stationary flame at the burner. | 2012-01-12 |
20120009534 | METHOD FOR FEEDING HOT GAS TO A SHAFT FURNACE - The present invention proposes a method for feeding hot gas to a shaft furnace ( | 2012-01-12 |
20120009535 | FLAME ADJUSTING STRUCTURE OF GAS BURNER - A flame adjusting structure is applied in a gas burner which accommodates a gas bottle and controls the gas discharge volume thereof for lighting a fire and producing a high temperature. The gas burner includes a pressing switch, a discharging component, a discharging tube, and a flame controlling gear. The flame adjusting structure includes a rotatable flame controlling component in a ring shape, which has flexibility and is sleeved around the flame controlling gear, inner teeth which are fixedly mounted on the inner edge of the rotatable flame controlling component and corresponding to and engaged with the teeth of the flame controlling gear, a sectional trench cutting off the ring of the rotatable flame controlling component, and elongation portions outwardly extended from the outer edges of the two ends of the sectional trench. | 2012-01-12 |
20120009536 | METHOD FOR PREHEATING ANNEALING PRODUCTS IN A HOOD-TYPE ANNEALING SYSTEM - A method is described for preheating annealing goods in a hood-type annealing installation, comprising two annealing bases ( | 2012-01-12 |
20120009537 | Orthodontic Appliance - The present invention provides an orthodontic appliance and wearing the orthodontic appliance can change the occlusion so as to solve the problem of conventional orthodontic appliance that might take long treatment duration. Through providing the orthodontic appliance to children with deciduous tooth, the permanent first molar can protrude from current position and move toward the neutral zone with better balance. Also, the present invention is invisible so as to concern user's feeling. | 2012-01-12 |
20120009538 | Orthodontic Bracket - Provided is an orthodontic bracket that is capable of a more effective three-dimensional motion and particularly an effective motion on the tooth surface. Specifically provided is an orthodontic bracket which comprises a substrate surface that is bonded to the tooth surface and an arch wire retaining portion that is configured to retain an arch wire with the substrate surface as a bottom surface, the orthodontic bracket being connected by the arch wire and continuously applying a stress to individual teeth to thereby straighten a row of teeth, wherein the orthodontic bracket is in an approximately hog-backed cross-sectional shape that is orthogonal to the direction in which the arch wire is stretched with the substrate surface bonded to the tooth surface as the bottom surface, and is provided with a plurality of arch wire through holes respectively for inserting the arch wires into the holes and connecting adjacent orthodontic brackets by the arch wires. | 2012-01-12 |
20120009539 | Intraoral Light-Emitting Device - The present invention relates to methods, systems, kits and devices that emit light to the oral cavity. The device includes a light source; a power source in electrical communication with the light source; and a bite actuated switch in electrical communication with the power source and the light source. The device is a size or shape that fits within an oral cavity of an individual. Since the device along with the light and power source are self contained, the user have their hands-free and can perform other activities while using the device. The device, methods, systems, and kits, further include the use of an agent (e.g., antibacterial agents, tooth whitening agents, cleaning agents) that assists or enhances the efficacy of the light therapy. | 2012-01-12 |
20120009540 | LED Tooth Whitening Device and Method of Tooth Whitening Using the Device - In an embodiment, a tooth whitening device includes a body having at least one LED disposed at an end of the body, and a mouthpiece removably attached to the body adjacent the LED. The mouthpiece can include an insertion end having a shape complimentary to an arch of upper and lower teeth of a user and sized to be received within the mouth of a user. The mouthpiece can include a wall at the insertion end that defines an opening. The wall surrounds buccal surfaces of the upper and lower teeth of the user such that at least a smile zone of the upper and lower teeth of the user is exposed through the opening. Light is transmitted from the LED through the opening to expose at least the smile zone of the upper and lower teeth. | 2012-01-12 |
20120009541 | DEVICE FOR HOLDING A MODEL - Device for holding a model of a dental prosthesis part, such as an abutment, including a first portion in which the mode of the dental prosthesis part can be modeled on and a second portion which allows a definite position identification of the holder, as well as a device for scanning objects, such as a jaw model and/or dental models and/or saw tooth model sections, comprising a holder in which an above-mentioned device with a definite position orientation can be held and scanned. Also provided is a method of generating a digital model of a dental prosthesis part, such as an abutment, including the steps of evaluating the scan data for detecting at least one part of the shape of the dental prosthesis part and evaluation of the scan data to detect at least the position of the holder, a data carrier with instructions to carry out such a method as well as a method of manufacturing a dental prosthesis part. | 2012-01-12 |
20120009542 | APPARATUS, SYSTEM, AND METHOD FOR REMOVAL OF DENTAL PROSTHESIS - An apparatus, system, and method are disclosed for facilitating removal of a dental prosthesis. A recess on a dental prosthesis is included and the dental prosthesis is mountable on one or more dental studs. The one or more dental studs are each connected to a dental implant in the jaw of a user. The recess includes a tool engaging surface, and the tool engaging surface has a shape corresponding to a recess engaging surface of a removal tool. The user may apply the recess engaging surface of the removal tool to the tool engaging surface of the recess and apply a force in a direction to remove the dental prosthesis from the one or more dental studs. | 2012-01-12 |
20120009543 | DENTAL TOOL - A dental tool includes a working head | 2012-01-12 |
20120009544 | GUIDE PIN FOR DENTAL IMPLANTATION - The guide pin in accordance with the present invention has an elongated body made from a ceramic material capable of bone density indication and comprising multiple coaxial cylindrical sections of different heights and diameters. | 2012-01-12 |
20120009545 | DEVICE FOR INDICATING THE POSITION AND ORIENTATION OF A DENTAL IMPLANT - A position locator for use in dental restorative procedure is described. The position locator is inserted into a replica of a dental implant or into a replica of an abutment. The position and orientation of the implant replica can be determined by scanning the model with the implant replica and the position locator. Alternatively, the position locator can be inserted into the dental implant and scanning can be carried out in the mouth of the patient. The position locator can be made of an optically opaque material, such as titanium, and can have an outer surface detectable by an optical scanner, e.g. with a layer of porous titanium oxide applied through anodic oxidation. | 2012-01-12 |
20120009546 | SEMI-WORKED PIECE FOR PRODUCTION OF DENTAL/ODONTOIATRIC DEVICES, NAMELY FOR POSTS, STUMPS AND DENTAL CROWNS - A semi-worked piece of composite material for producing artefacts/devices for dental and/or odontoiatric use such as posts and/or stumps and/or dental crowns for example, comprises a polymeric matrix and a multiplicity of mechanically resistant fibres nested in the polymeric matrix; in this semi-worked piece the resistant fibres are arranged in a predetermined number of reinforcing layers that are substantially planar and are disposed in mutually overlapped relationship. | 2012-01-12 |
20120009547 | TRUCK DRIVING SIMULATOR AND TRAINING METHOD - A truck driving simulator is provided, comprising a simulated cab with a steering wheel and dashboard layout, foot pedals (accelerator, clutch, brake), gear shifting mechanism, and a video screen. In another embodiment, a series of such simulators may be placed in a classroom together with a single large screen video monitor or television at the front of the class, so that multiple students can follow along with the video simulation under the supervision of a teacher or instructor. The video monitor(s) may be used to show video footage of the actual route that will be used to test the drivers for their trucker's license. This arrangement allows students to repeatedly practice driving the actual course used for their driver's license test, and to learn concepts like clutching, double clutching and switching gears without risking damage to an actual truck and transmission. | 2012-01-12 |
20120009548 | Swatch Organizer System and Method of Creating and Mounting Swatches - A swatch organizer system and method for preparing and mounting swatch samples and labels on a plurality of carriers that are secured onto a holder in a manner to allow the end user to easily evaluate the aesthetic nature of one or more swatch samples. Each carrier provides two surfaces for mounting swatches and/or labels. Mounting strips are provided to aid the end user in cutting, sizing and mounting raw materials such as fabric, paper, leather, etc. in the form of swatch samples onto carriers. Labeling is also provided to allow recording of descriptive information on the reverse of the carrier. Carriers, swatch samples and labels can be easily added, rearranged, removed or reused as desired. Supports design, organization and/or inventory needs with minimal time, effort and skill required by the end user. | 2012-01-12 |
20120009549 | SYSTEM AND METHOD FOR CAPTURING AND TRANSLATING BRAILLE EMBOSSING - The present disclosure describes, among other things, a device. The device includes a plurality of sensors, an output system, a processor coupled to the plurality of sensors and the output system, and a memory. The memory stores instructions that, when executed by the processor, cause the processor to receive a signal from the plurality of sensors, interpret the signal as a first Braille cell, and send a signal corresponding to the first Braille cell to the output system. | 2012-01-12 |
20120009550 | PERSONAL WELLBEING DEVICE AND SYSTEM - A device, a system and a computer program are provided for accepting and collecting demographic, OTC drug, prescription, and medical condition data, and outputting nutritional products, recipes, programs, meals, shopping lists, restaurant menus, and the like, designed for each unique user. | 2012-01-12 |
20120009551 | CUES TO POSITIVELY INFLUENCE EATING HABITS - A method of influencing eating habits of an individual including indicating upon an item a message regarding food intake, and positioning the item within areas of food consumption, preparation, or storage. An apparatus for influencing eating habits of an individual includes an item that can be displayed for viewing by an individual, and a message indicator placed upon the item, the message indicator including text or graphics indicating a message regarding food intake. | 2012-01-12 |
20120009552 | ANGER TRAINING CARD GAME - A method for playing a card game where players can practice expressing feelings of anger. A hand of letter cards is dwelt to players playing the game. A stack of topic cards is provided from which each player may draw. Each topic card includes an anger topic describing a situation commonly known to cause anger in the average person. A stack of letter cards is also provided. The player selects a topic card from the stack of topic cards. The player then verbalizes a sentence within a predetermined time period. The sentence must include the anger topic and a reason why the anger topic makes the player angry. If the player successfully verbalizes the sentence within the time limit he can then select a new letter card from the stack of letter cards. The winner of the game is the player who is able to use his letter cards in his hand to successfully spell a predetermined anger word or phrase. In a preferred embodiment, the anger phrase is “Pissed Off” and the winner is the player who is first able to successfully spell “Pissed Off” with his letter cards. | 2012-01-12 |
20120009553 | APPARATUS FOR ASSISTING SWIMMING TRAINING - A training system for assisting a coach to train a swimmer, including a swimmer side system and a coach side system electronically communicated. The swimmer wears a head-gear which includes a swimmer's data collection kit (SWDCK) which includes in turn sensors, a processor and a transceiver, A display for the swimmer is attached to a head belt or to goggles. A speaker for transferring audible information to the swimmer is typically a bone conduction speaker. A control module is operated by the coach, which includes a transmitter for communicating with the swimmer worn head-gear, a computer and a display and software, | 2012-01-12 |
20120009554 | INSTRUCTIONAL SHOELACE TYING SYSTEM - An instructional shoelace tying system. Identical identifiers are positioned on a right free end of a shoelace. Different identical identifiers are then positioned on the left free end of the shoelace. Another identifier might be positioned between the first set of identifiers. Kids can utilize such generally elongated hollow identifiers to quickly learn how to tie their shoelaces. | 2012-01-12 |
20120009555 | APPARATUS AND METHOD FOR RECOGNITION OF PATIENT ACTIVITIES - A medication confirmation method and apparatus. The method of an embodiment of the invention includes the steps of capturing one or more video sequences of a user administering medication via a medication administration apparatus, storing the captured one or more video sequences, and analyzing at least one of the stored video sequences to confirm that the user has properly administered the medication, and has properly positioned the medication administration apparatus. | 2012-01-12 |
20120009556 | Three-Dimensional Puzzle - A method, computer program product, and computing device comprising a game for testing the spatial reasoning of a player. The game includes a virtual multi-surfaced object having at least a first surface and a second surface, with first indicia associated with the first surface and second indicia associated with the second surface. A facing surface and a goal surface are displayed on a user interface, which also includes mechanisms for changing the orientation of the virtual object by rotating the object in steps. In response to input from the game player, the virtual object is rotated. Each time the virtual object is rotated, the facing surface displayed is changed so that it correlates to the changed orientation of the virtual object. The game continues until the game player causes the facing surface to match the goal surface by entering a series of rotational moves. | 2012-01-12 |
20120009557 | INTERACTIVE APPARATUS HAVING CONTACT SENSITIVE DISPLAY SCREEN CAPABLE OF DETECTING TWO OR MORE COINCIDENT CONTACTS - An interactive dual screen activity system and portable memory therefore, the system having a first display screen, a contact sensitive second display screen on which the user may make an input to the system by causing contact with the display screen, a button apparatus not associated with a keyboard or numeric keypad through which the user may make an input to the system by actuating a button, a first input method and a second input method, the first input method being where inputs to the system are triggered off of the user causing contact with the contact-sensitive display screen and the second input method being where inputs to the system are triggered off of actuation of the button, a microprocessor-based control system causing images to be presented on the first display screen and the second display screen, and a speaker. | 2012-01-12 |
20120009558 | METHOD AND APPARATUS FOR IDENTIFICATION OF BACTERIA - An automated system for identifying in a biological sample microorganisms and their antimicrobial susceptibility (AST). The system provided an automated platform for preparing, from a single biological sample, inoculates for both ID and AST. The system loads a plate for ID testing as samples are being prepared for AST testing. The system tracks the sample and the inoculates from the samples to link the test results to the sample and the patients from whom the sample was obtained. | 2012-01-12 |
20120009559 | AUTOMATED CELL CULTURE SYSTEM AND PROCESS - The present invention relates generally to the field of cell culture, which is a laboratory process used primarily for the growth, propagation, and production of cells for analysis and the production and harvesting of cell products. The present invention comprises functionalized and/or engineered hydrogel microcarriers that exhibit any or all of the following properties: controllable buoyancy, ferro- or paramagnetism, molecular or fabricated reporting elements, and optical clarity. The microcarriers are used in a bioreactor that employs external forces to control said microcarrier kinetic energy and translational or positional orientation in order to facilitate cell growth and/or cellular analysis. The bioreactor can be part of an automated system that employs any or all of the following; a microcarrier manufacturing method, a monitoring method, a cell culture method, and an analytical method. Either a single bioreactor or a plurality of bioreactors are used in the automated system to enable cell culture and analysis with a minimum of human intervention. | 2012-01-12 |
20120009560 | Method For Purifying Nucleic Acids From Microorganisms Present In Liquid Samples - The present invention relates to a method for treating liquid samples with a view to detecting any possible pathogenic microorganisms in a very small amount. More specifically, this method comprises a generic step of capturing and concentrating microorganisms on an ion exchange surface, followed by an in situ lysis treatment carried out on the microorganisms and capture of the nucleic acids released during the lysis. The implementation of this method enables an extremely concentrated and purified solution of nucleic acids to be obtained. This method is suitable for a continuous treatment of liquid samples. The invention also relates to a device for analysing liquid samples for biology, health or the environment, which is suitable for the implementation of the method according to the invention. | 2012-01-12 |
20120009561 | METHODS OF EVALUATING A TEST AGENT IN A DISEASED CELL MODEL - The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the tissues of the immune system in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates and other materials in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system, coupled with disease models to provide a more complete representation of an immune response. | 2012-01-12 |
20120009562 | High-Risk Human Papillomavirus Detection - This invention provides compositions and methods for detecting HPV in a sample. This invention also provides related kits, systems, and computers. | 2012-01-12 |
20120009563 | High-Risk Human Papillomavirus Detection - This invention provides compositions and methods for detecting HPV in a sample. This invention also provides related kits, systems, and computers. | 2012-01-12 |
20120009564 | High-Risk Human Papillomavirus Detection - This invention provides compositions and methods for detecting HPV in a sample. This invention also provides related kits, systems, and computers. | 2012-01-12 |
20120009565 | COMPOSITIONS AND METHODS FOR DETECTION OF HEPATITIS A VIRUS NUCLEIC ACID - Nucleic acid oligomeric sequences and in vitro nucleic acid amplification and detection methods for detecting the presence of HAV RNA sequences in samples are disclosed. Kits comprising nucleic acid oligomers for amplifying and detecting HAV nucleic acid sequences are disclosed. | 2012-01-12 |
20120009566 | LUMINESCENCE ASSAY METHOD - A bioassay employing a first group including a lanthanide ion carrier chelate and a first recognition element, a second group including an antenna ligand and a second recognition element; where the lanthanide ion carrier chelate binds strongly to lanthanide, or the lanthanide ion carrier chelate binds moderately to lanthanide, and an agent complexing the lanthanide ion is additionally employed at a concentration of at least 1 pmol/l. The antenna ligand binds weakly to the lanthanide ion. Analyte recognition by the first recognition element and by the second recognition element results in either chelate complementation and increased fluorescence, or chelate discomplementation and decreased fluorescence. | 2012-01-12 |
20120009567 | SEQUENCING REACTIONS WITH ALKALI METAL CATIONS FOR PULSE WIDTH CONTROL - Compositions, kits, methods and systems for single molecule nucleotide sequencing comprising producing polymerase reactions having monovalent cations that control the median pulse width for incorporated nucleotides are disclosed. The levels of alkali metals such as lithium, sodium, potassium, rubidium, and cesium in the polymerization are used to control pulse width while allowing other sequencing parameters to remain within a desirable range. | 2012-01-12 |
20120009568 | THERMOELECTRIC METHOD OF SEQUENCING NUCLEIC ACIDS - The present invention relates to a novel thermoelectric method for determining the sequence of nucleotides on a nucleic acid molecule through use of a thermopile and/or sequencing reagents flowing under the conditions of laminar flow. The methods disclosed herein involve the measurement of the heat generated by a deoxynucleotide incorporation event that can be accomplished without the need to control the temperature of any of a thermopile's junctions. | 2012-01-12 |
20120009569 | MICROORGANISM CONCENTRATION PROCESS AND DEVICE - A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising a sintered porous polymer matrix comprising at least one concentration agent that comprises diatomaceous earth bearing, on at least a portion of its surface, a surface treatment comprising a surface modifier comprising ferric oxide, titanium dioxide, fine-nanoscale gold or platinum, or a combination thereof; (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration device with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration device. | 2012-01-12 |
20120009570 | Restoration of Nucleic Acid From Degraded or Formalin-Fixed and Paraffin-Embedded Tissue and Uses Thereof - This invention provides methods, primers and kits for restoration of nucleic acid from tissue, in particular degraded tissue and formalin-fixed and paraffin-embedded (FFPE) tissue, where the methods involve complementary-template reverse-transcription (CT-RT) where short single-stranded DNA sequences reverse-transcribed from mRNA are used for reverse-transcription of complementary sense-RNA templates. The methods can be used to determine patterns of gene expression and chromosomal alterations in archived tissue samples, and may be used to identify expression of disease-related genes. | 2012-01-12 |
20120009571 | TMPRSS2 FOR THE DIAGNOSIS OF PROSTATE DISEASE - Described herein are methods, compositions and kits directed to the detection the 5′ portion of TMPRSS2 mRNA for the detection and diagnosis of prostate disease including prostate cancer and benign prostatic hyperplasia. | 2012-01-12 |
20120009572 | Novel single nucleotide polymorphisms and community-associated methicillin-resistant staphylococcus aureus - The present invention is based on the discovery of novel polymorphisms (SNPs) in the penicillin binding protein (pbp3) gene in | 2012-01-12 |
20120009573 | Antisense Transcriptomes of Cells - Transcription in mammalian cells can be assessed at a genome-wide level, but it has been difficult to reliably determine whether individual transcripts are derived from the Plus- or Minus-strands of chromosomes. This distinction can be critical for understanding the relationship between known transcripts (sense) and the complementary antisense transcripts that may regulate them. Here we describe a technique that can be used to (i) identify the DNA strand of origin for any particular RNA transcript and (ii) quantify the number of sense and antisense transcripts from expressed genes at a global level. We examined five different human cell types and in each case found evidence for antisense transcripts in 2900 to 6400 human genes. The distribution of antisense transcripts was distinct from that of sense transcripts, was non-random across the genome, and differed among cell types. Anti-sense transcripts thus appear to be a pervasive feature of human cells, suggesting that they are a fundamental component of gene regulation. | 2012-01-12 |
20120009574 | DETECTION OF LISTERIA SPECIES IN FOOD AND ENVIRONMENTAL SAMPLES, METHODS AND COMPOSITIONS THEREOF - Embodiments of the disclosure relate to isolated nucleic acid sequences, methods of use thereof, and workflows for detection of several | 2012-01-12 |
20120009575 | INDUCIBLE NUCLEIC ACID TARGETS FOR DETECTION OF PATHOGENS, METHODS AND COMPOSITIONS THEREOF - The present application describes compositions, methods and kits for rapid detection and identification of various microorganisms using inducible RNA. Methods for rapidly detecting microorganisms by detecting expression of inducible RNA of target genes following induction of a target gene using an inducer are described. Some embodiments describe methods and workflows for rapidly detecting microbes such as, but not limited to, | 2012-01-12 |
20120009576 | Probe for Detection of Polymorphism in ABL Gene, and Use Thereof - A probe for detecting a polymorphism in ab1 gene, said probe comprising at least one fluorescence-labeled oligonucleotide selected from P1 below:
| 2012-01-12 |
20120009577 | Detection of Nucleic Acids Through Amplification of Surrogate Nucleic Acids - Methods for detecting and optionally quantitating one or more target nucleic acids are provided, in which a surrogate nucleic acid is captured to each target nucleic acid, amplified, and detected. Compositions, kit, and systems related to the methods are also described. | 2012-01-12 |
20120009578 | Microvesicle-Based Compositions and Methods - Methods and compositions for diagnosis and/or analysis of a condition in a mammal are disclosed in which RNA from microvesicles is enriched and differentiated to so obtain a result that is indicative of the condition of tissue or organ from which the microvesicle originated. In especially preferred embodiments, the condition is a neoplastic disease of a human and can be identified and staged by differential analysis of one or more distinct RNAs, optionally together with identification and analysis of a non-RNA component of the microvesicle. | 2012-01-12 |
20120009579 | MONOCYTE-DERIVED NUCLEIC ACIDS AND RELATED COMPOSITIONS AND METHODS - Nucleic acids encoding various monocyte-derived proteins and related compositions, including purified proteins and specific antibodies are described. Methods of using such composition are also provided. | 2012-01-12 |
20120009580 | METHODS FOR QUANTITATING SMALL RNA MOLECULES - In one aspect, the present invention provides methods for amplifying a microRNA molecule to produce DNA molecules. The methods each include the steps of: (a) using primer extension to make a DNA molecule that is complementary to a target microRNA molecule; and (b) using a universal forward primer and a reverse primer to amplify the DNA molecule to produce amplified DNA molecules. In some embodiments of the method, at least one of the forward primer and the reverse primer comprise at least one locked nucleic acid molecule. | 2012-01-12 |
20120009581 | Gene Expression Profiling for Predicting the Survivability of Prostate Cancer Subjects - A method is provided in various embodiments for determining a profile data set for predicting the survivability of a subject with prostate cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification under measurement conditions that are substantially repeatable for measuring the amount of RNA corresponding to at least 1 constituent from Table 1. Alternatively, the method uses electrophoresis or immunohistochemistry for measuring the mount of protein corresponding to at least 1 constituent from Table 20. The profile data set comprises the measure of each constituent. | 2012-01-12 |
20120009582 | DIAGNOSIS AND TREATMENT OF BREAST CANCER - The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to compositions and methods for the prediction of a subject's response to cancer therapies. | 2012-01-12 |
20120009583 | Method for Producing Highly Sensitive Endonucleases, Novel Preparations of Endonucleases and Uses Thereof - The present invention pertains to methods for producing recombinant endonucleases having a high sensitivity, as well as to endonucleases preparations obtained by said methods, and uses thereof, especially for the detection of mismatches. | 2012-01-12 |
20120009584 | METHOD FOR DETECTING AND QUNANTIFYING ENDOGENOUS WHEAT DNA SEQUENCE - It is an object of the present invention to provide partial sequences of endogenous wheat DNA (genome) which are single copies and which allow wheat to be specifically detected without cross-reacting with other plants in PCR, and to provide primers for amplifying these partial sequences, along with a good method for detecting and quantifying endogenous DNA using these primers. The present invention provides, in a method for detecting or quantifying an endogenous wheat DNA sequence in a test sample by means of a polymerase chain reaction, a method comprising a step of using a nucleic acid in the test sample or a nucleic acid extracted from the test sample as a template to amplify the nucleic acid of a region comprising at least 80% or more of a nucleotide sequence represented by one of SEQ ID NO:1 through SEQ ID NO:7 using a primer pair capable of amplifying that region, and a step of detecting or quantifying the amplified nucleic acid. | 2012-01-12 |
20120009585 | METHOD FOR DETECTING AND QUNANTIFYING ENDOGENOUS WHEAT DNA SEQUENCE - It is an object of the present invention to provide partial sequences of endogenous wheat DNA (genome) which are single copies and which allow wheat to be specifically detected without cross-reacting with other plants in PCR, and to provide primers for amplifying these partial sequences, along with a good method for detecting and quantifying endogenous DNA using these primers. The present invention provides, in a method for detecting or quantifying an endogenous wheat DNA sequence in a test sample by means of a polymerase chain reaction, a method comprising a step of using a nucleic acid in the test sample or a nucleic acid extracted from the test sample as a template to amplify the nucleic acid of a region comprising at least 80% or more of a nucleotide sequence represented by one of SEQ ID NO:1 through SEQ ID NO:7 using a primer pair capable of amplifying that region, and a step of detecting or quantifying the amplified nucleic acid. | 2012-01-12 |
20120009586 | METHOD FOR DETECTING AND QUNANTIFYING ENDOGENOUS WHEAT DNA SEQUENCE - It is an object of the present invention to provide partial sequences of endogenous wheat DNA (genome) which are single copies and which allow wheat to be specifically detected without cross-reacting with other plants in PCR, and to provide primers for amplifying these partial sequences, along with a good method for detecting and quantifying endogenous DNA using these primers. The present invention provides, in a method for detecting or quantifying an endogenous wheat DNA sequence in a test sample by means of a polymerase chain reaction, a method comprising a step of using a nucleic acid in the test sample or a nucleic acid extracted from the test sample as a template to amplify the nucleic acid of a region comprising at least 80% or more of a nucleotide sequence represented by one of SEQ ID NO:1 through SEQ ID NO:7 using a primer pair capable of amplifying that region, and a step of detecting or quantifying the amplified nucleic acid. | 2012-01-12 |
20120009587 | Recombinant adenovirus target-oriented co-expressing human p53 and p53aip1 - A recombinant adenovirus target-oriented co-expressing human p53 variant and p53AIP1 is disclosed, which is inserted an expression cassette co-expressing human p53 variant and p53AIP1 in E1 deletion region of the adenovirus. The expression cassette consists of tumor specific promoter, human p53 variant, internal ribosome entry site (IRES), human p53AIP1, and SV40. | 2012-01-12 |
20120009588 | LIVE BIOLOAD DETECTION USING MICROPARTICLES - The present invention provides methods to concentrate cells onto microparticles, to concentrate the microparticles, and to detect the cells. The present invention also includes unitary sample preparation and detection devices to be used in accordance with the methods. | 2012-01-12 |
20120009589 | SUB-DIFFRACTION IMAGE RESOLUTION AND OTHER IMAGING TECHNIQUES - The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity. The emitted light may be used to determine the positions of the first and second entities, for example, using Gaussian fitting or other mathematical techniques, and in some cases, with sub-diffraction limit resolution. The methods may thus be used, for example, to determine the locations of two or more entities immobilized relative to a common entity, for example, a surface, or a biological entity such as DNA, a protein, a cell, a tissue, etc. The entities may also be determined with respect to time, for example, to determine a time-varying reaction. Other aspects of the invention relate to systems for sub-diffraction limit image resolution, computer programs and techniques for sub-diffraction limit image resolution, methods for promoting sub-diffraction limit image resolution, methods for producing photoswitchable entities, and the like. | 2012-01-12 |
20120009590 | DEVICE AND NON-TOXIC COMPOSITIONS AND METHODS FOR PERMEABILIZATION OF DROSOPHILA EMBRYOS - The invention provides compositions and methods for permeabilizing insect embryos by removing the waxy layer of the shell using a solution containing a non-toxic cyclic terpene and a non-toxic surfactant, preferably a non-ionic surfactant. The invention further provides kits to practice the method of the invention. The invention also provides methods for toxicology and other high throughput screening method including the compositions and methods of embryo permeabilization provided herein. | 2012-01-12 |
20120009591 | METHOD FOR DETECTION OF AN ENZYME-SUBSTRATE REACTION - The present invention relates to a method for detection of an enzyme-substrate reaction by capturing the product of the reaction on a solid support. More closely, the invention relates to a solid phase system for enzyme characterisation and screening of enzyme-targeted drugs. The method comprises the following steps a) rapidly mixing an enzyme solution with a substrate solution to start a reaction between enzyme and substrate wherein said reaction may result in product formation; and b) monitoring any binding of the product to a capturing agent immobilised on a solid surface, wherein said capturing agent is directed against the product of the enzymatic reaction. In a preferred embodiment the method comprises a further step c) measuring the initial rate of the product binding to the capturing agent and thereby characterize the enzymatic reaction. The method may also be used for drug screening. | 2012-01-12 |
20120009592 | ENPP1 (PC-1) GENE HAPLOTYPE ASSOCIATED WITH THE RISK OF OBESITY AND TYPE 2 DIABETES AND THEIR APPLICATIONS - The present invention is directed to a method for determining if a subject is at increased risk to develop obesity or pathology related to obesity by determining the presence of a haplotype comprising three specific SNPs in a DNA or RNA sample of this subject and/or an elevated serum ENPP1 protein concentration. The present invention also relates to a kit and to an isolated nucleic sequence, vector or recombinant cell comprises said ENPP1 gene haplotype. The invention further comprises a method for selecting a compound for the treatment or the prevention of obesity or pathology related to obesity and a method for determining the efficacy of a drug to reduce the risk of obesity or pathology related to obesity in a patient. | 2012-01-12 |
20120009593 | ANALYSIS METHOD FOR THE IN VITRO DIAGNOSIS OF BENIGN PROSTATIC HYPERPLASIA (BPH) IN DOGS BY ASSAYING CANINE PROSTATE SPECIFIC ESTERASE, AND BPH TREATMENT FOLLOW UP - The invention relates to an analysis method for the in vitro diagnosis of benign prostatic hyperplasia (BPH) in a dog, using the CPSE contained in biological fluid samples collected from the dog as well as biological molecules specifically binding CPSE. The invention is characterised in that it includes the following steps: a. collecting a biological fluid sample from a dog; b. measuring the canine prostate specific esterase (CPSE) of said sample; c. comparing said measured CPSE concentration with a reference value, said value being from around 34 ng/ml to around 102.4 ng/ml for serum or plasma, preferably around 61 ng/ml; d. using the CPSE concentration as a BPH marker; and e. diagnosing BPH in a dog when measured CPSE concentrations in said sample exceed said reference value. | 2012-01-12 |
20120009594 | METHOD FOR MEASURING BETA-GLUCAN, AND BETA-GLUCAN-BINDING PROTEIN FOR USE IN THE METHOD - Disclosed are a method for measuring βG comprising the steps of bringing a sample into contact with a βG-binding protein 1 and a βG-binding protein 2, each comprising an amino acid sequence which is identical or substantially identical to an amino acid sequence shown in any one of SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, or SEQ ID NO:20, and having the β-glucan binding activity, to form a complex of the βG-binding protein 1, βG in the sample and the βG-binding protein 2, measuring quantity of the complex, and determining βG concentration in the sample based on the quantity of the complex; a reagent and a kit for use in said method; a novel βG-binding protein; a nucleic acid molecule encoding the βG-binding protein; and a method for producing the aforementioned βG-binding protein. | 2012-01-12 |
20120009595 | BINDING OF AGGREGATED FORMS OF PROTEINS - Aggregating proteins such as IgG, are bound selectively in the presence of the non-aggregated protein using a polyionic binding agent such as dextran sulphate or pentosan (anionic), or polyamine compounds such as pDADMAC (cationic) under selective binding conditions including the use of n-lauroylsarcosine at mildly alkaline pH, and may then be assayed. | 2012-01-12 |
20120009596 | PROTEIN MARKERS FOR DETECTING LIVER CANCER AND METHOD FOR IDENTIFYING THE MARKERS THEREOF - The present invention relates to the diagnosis of liver cancer. It discloses the use of protein ERBB3 and protein IGFBP2 in the diagnosis of liver cancer. It relates to a method for diagnosis of liver cancer from a liquid sample, derived from an individual by measuring ERBB3 protein and IGFBP2 protein in the sample. Measurement of ERBB3 protein and IGFBP2 protein can, e.g., be used in the early detection or diagnosis of liver cancer. | 2012-01-12 |
20120009597 | Biomarker for Barrett's Oesophagus - The present invention relates to the use of TFF3 in the diagnosis and detection of Barrett's Oesophagus using non-invasive, non-endoscopic methods. | 2012-01-12 |
20120009598 | T2R, A NOVEL FAMILY OF TASTE RECEPTORS - The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors. | 2012-01-12 |