02nd week of 2011 patent applcation highlights part 47 |
Patent application number | Title | Published |
20110009571 | SYSTEMS AND METHODS FOR DELIVERY OF MATERIALS - Systems and methods for delivering release materials, for example drugs and other bioactive materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the release materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class of non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. For some uses, particularly the delivery of drugs, a bioerodable CYC carrier is preferably used. | 2011-01-13 |
20110009572 | POLYMER BLENDS CONTAINING POLYDIORGANOSILOXANE UREA COPOLYMERS - Polymer blends containing organopolysiloxane-polymer-polyurethane copolymers and thermoplastic polymers bearing epoxy, carboxylic acid, carboxylic acid ester, or carboxylic acid anhydride groups exhibit enhanced physical properties. | 2011-01-13 |
20110009573 | Hydrosilylation Catalysts - Disclosed herein are manganese, iron, cobalt, or nickel complexes containing terdentate pyridine diimine ligands and their use as efficient and selective hydrosilylation catalysts. | 2011-01-13 |
20110009574 | MODIFIED NAPHTHALENE FORMALDEHYDE RESIN, TRICYCLODECANE SKELETON-CONTAINING NAPHTHOL COMPOUND AND ESTER COMPOUND - A modified dimethylnaphthalene formaldehyde resin is disclosed, which is excellent in heat resistance and useful for thermosetting resins which are used for an electrical insulating material, a resin for resist, a semiconductor sealing resin, an adhesive for printed wiring board, a matrix resin for electrical laminate or prepreg to be mounted in electrical instruments, electronic instruments, industrial instruments, etc., a buildup laminate material, a resin for fiber-reinforced plastic, a sealing resin for liquid crystal display panel, a paint, a variety of coating agents, an adhesive, a laminate for electrical or electronic parts, a molded article, a coating material, a sealing material and the like, the modified dimethylnaphthalene formaldehyde resin being obtained by modifying a polyfunctional dimethylnaphthalene formaldehyde resin having a constituent unit represented by the following general formula [1] in a molecule thereof with at least one member selected from the group consisting of a phenol represented by the following general formula [2], a naphthol represented by the following general formula [3] and a naphthol represented by the following general formula [4] (provided that at least any of the naphthol represented by the general formula [3] or the naphthol represented by the general formula [4] must be included). | 2011-01-13 |
20110009575 | Semi Continuous Operational Method For Producing Copolymers - The invention relates to a process for the preparation of a copolymer in a semicontinuous mode of operation in a polymerization apparatus containing a polymerization reactor connected to a metering device, in each case acid monomer being initially introduced into the metering device and polyether macromonomer and water into the polymerization reactor, acid monomer being metered from the metering device into the polymerization reactor, free radical polymerization initiator being passed into the polymerization reactor before and/or during the metering of the acid monomer into the polymerization reactor, so that an aqueous medium forms in the polymerization reactor, in which aqueous medium acid monomer and polyether macromonomer are reacted by free radical polymerization with formation of the copolymer, at least 70 mol % of the polyether macromonomer initially introduced into the polymerization reactor being converted by the free radical polymerization, the conversion of the acid monomer giving rise in the copolymer to an acid structural until which reduces the pH of the aqueous medium to a lesser extent than the acid monomer as such, the metering of the acid monomer into the polymerization reactor being effected in such a way that first a polymerization pH is established in the aqueous medium and then, until the conversion of 70 mol % of the polyether macromonomer initially introduced into the polymerization reactor, acid monomer is passed into the polymerization reactor in an amount per unit time such that the pH in the aqueous medium deviates by not more than ±0.3 from the initially established polymerization pH. | 2011-01-13 |
20110009576 | POLYMERISATION PROCESS - The present invention relates to a polymerisation process and in particular to a process for the copolymerisation of ethylene and an α-olefin comonomer having 7 to 10 carbon atoms in a fluidised bed gas phase reactor in the presence of a multi-site Ziegler-Natta polymerisation catalyst characterised in that (i) said process is operated in condensed mode, (ii) the amount of said α-olefin is maintained below that at which substantial condensation in the reactor occurs and (iii) at least one of the following apply: | 2011-01-13 |
20110009577 | ENHANCED CONDENSED MODE OPERATION IN METHOD OF PRODUCING POLYOFEFINS WITH CHROMIUM BASED CATALYSTS - A gas phase polymerization process for producing a polyethylene polymer including polymerizing ethylene and optionally at least one α-olefin comonomer in a fluidized bed reactor under condensed mode operating conditions using a Cr | 2011-01-13 |
20110009578 | Use Of A Combination Chain Transfer And Activating Agent To Control Molecular Weight And Optical Density Of Pd Catalyzed Norbornene Polymers - A method of controlling the molecular weight of poly(cyclic) olefin (norbornene-type) polymers and activating the polymerization thereof with a single material is provided. Such method include adding a chain transfer/activating agent to a mixture of monomer(s), catalyst, solvent and an optional cocatalyst and polymerizing the mixture to form a polymer. It is shown that the amount of chain transfer/activating agent in the mixture can serve to control the molecular weight of the resulting polymer, its percent conversion or both, and in some embodiments the optical density of the resulting polymer. | 2011-01-13 |
20110009579 | Processes For Producing A Catalyst Component For Addition Polymerization, A Catalyst And An Addition Polymer - A production process of a polymerization catalyst component includes contacting compound (a) such as diethyl zinc represented by the defined formula [1], a compound (b) such as pentafluorophenol, represented by the defined formula [2], a compound (c) such as water, represented by the defined formula [3], and particles (d), such as silica, with one another in a hydrocarbon solvent under an agitator power of 0.05 kW/m | 2011-01-13 |
20110009580 | Novel copolymers - A copolymer of ethylene and an alpha-olefin, said copolymer having a (a) density>0.930 g/cm | 2011-01-13 |
20110009581 | METHOD OF PREPARING A CATALYTIC COMPOSITION FOR DIMERIZATION, CO-DIMERIZATION AND OLIGOMERIZATION OF OLEFINS - The present invention describes a method of preparing a catalytic composition used for oligomerization, co-dimerization or polymerization of olefins, wherein the compound obtained upon contacting at least one iron compound with at least one nitrogen-containing compound is subjected to an oxidation stage prior to being mixed with an activating agent and optionally with a solvent. | 2011-01-13 |
20110009582 | Preparation of Activating Supports - The present invention discloses a method for preparing an activating support and its use to activate metallocene or post-metallocene catalyst component for use in the oligomerisation and polymerisation of ethylene and alpha-olefins. | 2011-01-13 |
20110009583 | FUNCTIONALIZED POLYMERS AND INITIATORS FOR MAKING SAME - A polymer includes at a terminus a cyclic amine radical bonded to the polymer through a ring nitrogen atom. The polymer can be provided by using a lithiated version of the cyclic amine to initiate polymerization of one or more ethylenically unsaturated monomers. The polymer can be used in the production in a variety of vulcanizates. | 2011-01-13 |
20110009584 | Romp-Polymerizable Electron Transport Materials Based On A Bis-Oxadiazole Moiety - This invention relates generally to a solution processable norbornene monomer, poly(norbornene) homopolymer, and poly(norbornene) copolymer compounds containing a functionalized bis-oxadiazole side chain, and to an electron injecting/transporting layer, a hole-blocking layer, or an emissive material, organic electronic devices and compositions which include these compounds. | 2011-01-13 |
20110009585 | THERMOPLASTIC ACRYLIC RESIN AND MOLDED BODY FOR OPTICAL MEMBER - The present invention provides a thermoplastic acrylic resin comprising (i) a repeating unit derived from a methacrylate monomer, (ii) a repeating unit derived from a vinyl aromatic monomer, (iii) a repeating unit derived from an aromatic group-containing methacrylate monomer, and (iv) a cyclic acid anhydride repeating unit, and a molding for optical material comprising the same. | 2011-01-13 |
20110009586 | POLYMER, CURABLE RESIN COMPOSITION, CURED PRODUCT, AND ARTICLE - A polymer which has a radical polymerizable unsaturated group in a side chain and can be made a molecular design suitable for the purpose; a curable resin composition containing the polymer, which provides a cured product having high surface hardness after curing and hardly suffering from scratch; the cured product; and an article obtained by laminating the cured product are provided. | 2011-01-13 |
20110009587 | MONO ETHYLENICALLY UNSATURATED POLYCARBOSILOXANE MONOMERS - The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain monoethylenically unsaturated polycarbosiloxane monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. | 2011-01-13 |
20110009588 | COUPLED POLYMERS AND MANUFACTURING METHOD THEREOF - A coupled copolymer is provided. The coupled copolymer is coupled by reacting a silane coupling agent with a copolymer, where the copolymer is polymerized by a conjugated diene monomer and a vinyl aromatics monomer, and the silane coupling agent has an alkenyl group and a alkoxy group, and has a chemical Formula (I) as follows: | 2011-01-13 |
20110009589 | DEGRADABLE HETEROBIFUNCTIONAL POLY(ETHYLENE GLYCOL) ACRYLATES AND GELS AND CONJUGATES DERIVED THEREFROM - A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coupling to a target. Hydrogels can be prepared. The hydrogels can be used as a carrier for a protein or a pharmaceutical agent that can be readily released in a controlled fashion. | 2011-01-13 |
20110009590 | METHOD FOR PRODUCING PARTICULATE WATER - ABSORBING AGENT COMPOSED PRINCIPALLY OF WATER ABSORBING RESIN - Provided is a production method for the particulate water-absorbing agent, which can contribute to property enhancement, and further improvement of productivity or the like, as well. One example of the production method for the particulate water-absorbing agent relevant to the present invention includes the polymerization step for obtaining a polymer gel; the drying step for drying the polymer gel to obtain a dried substance; the pulverization step for pulverizing the dried substance or the polymer gel to obtain the particulate water-absorbing resin; the classification step for sieving the particulate water-absorbing resin; the granule sizing step for granule sizing the particulate water-absorbing agent obtained from the particulate water-absorbing resin; and the transporting step for transporting the products produced in each of the steps to other steps. Preferably, one or more steps selected from the pulverization step, the classification step, the granule sizing step and the transporting step after the pulverization step are set under reduced pressure state. | 2011-01-13 |
20110009591 | High Index and High Impact Resistant Poly(thio)urethane/Urea Material, Method of Manufacturing Same and Its Use in the Optical Field - A transparent, non elastomeric, high refractive index, impact resistant poly(thio)urethane/urea material comprising the reaction product of: a) at least one (α, ω)-diiso(thio)cyanate cycloaliphatic or aromatic polysulfide prepolymer, and b) at least one aromatic primary diamine, in an equivalent molar ratio amine function/iso(thio)cyanate function ranging from 0.5 to 2, wherein, said prepolymer and diamine are free from disulfide (—S—S—) linkage and wherein the (α, ω)-diiso(thio)cyanate polysulfide prepolymer is the reaction product of at least one cycloaliphatic or aromatic diiso(thio)cyanate and at least one (α, ω)-diol prepolymer. | 2011-01-13 |
20110009592 | PROCESS FOR THE PREPARATION OF POLYCARBONATE - A combined process for the preparation of polycarbonate from bisphenols and diaryl carbonates, the monophenol liberated being reacted again for the preparation of the diaryl carbonate and the alkali metal halide forming in the preparation of the diaryl carbonate being converted by electrochemical oxidation, optionally over a gas diffusion electrode, into chlorine and alkali hydroxide solution, the chlorine being recycled into the preparation of the phosgene and the alkali hydroxide solution being recycled into the preparation of the diaryl carbonate. | 2011-01-13 |
20110009593 | Polymeric Bioplastics - One aspect of the present invention relates to a polymeric material. The invention also relates to a method of making the aforementioned polymer comprising extracting a fungus, wherein the fungus is, for example, an endophytic fungus, such as CR873. The invention further relates to a bioplastic composition comprising the aforementioned polymer. | 2011-01-13 |
20110009594 | MULTIFUNCTIONAL FORMS OF POLYOXAZOLINE COPOLYMERS AND DRUG COMPOSITIONS COMPRISING THE SAME - The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents. | 2011-01-13 |
20110009595 | SOLVENT RESISTANT POLYMERS - What is disclosed relates to polymers that resist dissolution in organic solvents, are vasodilators, and are tunable explosives. These polymers also form solvent resistant coatings and solvent resistant fibers as well as bonding materials. | 2011-01-13 |
20110009596 | PROCESS FOR THE PREPARATION OF N-PROTECTED-DECYLAMINOETHANAL - Compounds useful in the preparation of telavancin, for example, were prepared. These compounds include decylaminoethanal dialkyl acetals and N-protected decylaminoethanal dialkyl acetals, imidazolidine derivatives, and N-protected-decylaminoethanal. | 2011-01-13 |
20110009597 | RECOMBINANT GANODERMA LUCIDIUM IMMUNOMODULATORY PROTEIN (rLZ-8) AND USES THEREOF - Provided are the use of the recombinant | 2011-01-13 |
20110009598 | METHOD OF PRODUCING CELL EXTRACT FOR CELL-FREE PROTEIN SYNTHESIS - A cell extract for cell-free protein synthesis is produced by removing substances, which bind to an affinity support to be used in purification or interaction analysis, from a cell extract having protein synthetic activity. Then, a target protein is synthesized by using the cell extract for cell-free protein synthesis. The synthesized target protein can be purified by using the affinity support and used in interaction analysis. | 2011-01-13 |
20110009599 | APO-2 RECEPTOR POLYPEPTIDES - Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided. | 2011-01-13 |
20110009600 | Recombinant Antibody Composition - The present invention relates to a recombinant antibody composition having higher complement-dependent cytotoxic activity than a human IgG1 antibody and a human IgG3 antibody, wherein a polypeptide comprising a CH2 domain in the Fc region of a human IgG1 antibody is replaced by a polypeptide comprising an amino acid sequence which corresponds to the same position of a human IgG3 antibody indicated by the EU index as in Kabat, et al.; a DNA encoding the antibody molecule or a heavy chain constant region of the antibody molecule contained in the recombinant antibody composition; a transformant obtainable by introducing the recombinant vector into a host cell; a process for producing the recombinant antibody composition using the transformant; and a medicament comprising the recombinant antibody composition as an active ingredient. | 2011-01-13 |
20110009601 | LABELED PROTEIN AND METHOD FOR OBTAINING THE SAME - It is an object of the present invention to obtain a labeled protein, and specifically, to separate a labeled protein and the same unlabeled protein. There is provided a labeled protein including: a protein to be labeled having a target protein, at least one or more affinity interaction domains for binding to an affinity support, and at least one or more labeling sites; and a labeling reagent binding to at least one of the labeling sites; wherein the affinity of the labeled protein for the affinity support is difference from that of the protein to be labeled for the affinity support. | 2011-01-13 |
20110009602 | HUMAN CD28 SPECIFIC MONOCLONAL ANTIBODIES FOR ANTIGEN-NONSPECIFIC ACTIVATION OF T-LYMPHOCYTES - The invention teaches human-compatible monoclonal antibodies which are specific against human CD28 and human T-lymphocytes of several to all subgroups to activate without occupancy of an antigen receptor of the human T-lymphocytes and thus antigen-non-specifically. | 2011-01-13 |
20110009603 | Method and composition for crystallizing G protein-coupled receptors - Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, where the second portion comprises the TM6 and TM7 regions of the GPCR. | 2011-01-13 |
20110009604 | Method for Concentrating, Purifying and Removing Prion Protein - The present invention relates to a method for concentrating and/or purifying prion PrP | 2011-01-13 |
20110009605 | NOVEL CONTRAST AGENTS - This invention includes agents and compositions having MRI, PET, CT, X-ray, SPECT or optical signals, and methods for their use in the determination of a target. In some cases, a MRI, PET, CT, X-ray, SPECT, optical or other signal produced by the agent or composition can be affected by the presence of the target. Examples of targets that can be determined by this invention include, but are not limited to zinc, copper, iron ions and other biological targets. Example of application for imaging in vivo includes the function of pancreas and other organs. | 2011-01-13 |
20110009606 | Synthesis of 2',3' - and 3',5' -cyclic phosphate mono-and oligonucleotides - The invention provides a novel method of 2′,3′-cyclic phosphate and phosphorothioate of mono and oligonucleotide synthesis. The invention also provides a novel method of the synthesis of 3′,5′-cyclic phosphate and phosphorothioate mononucleotide. The invention also envisions providing kits comprising at least one composition disclosed in the present invention. | 2011-01-13 |
20110009607 | METHOD FOR PREPARING DNA FRAGMENT HAVING STICKY END - The present invention provides a method for preparing a DNA fragment, in which a desired double-stranded DNA fragment having a sticky end is directly and easily obtained from an amplification product (an amplified fragment) after PCR without a restriction enzyme digestion. The method for preparing a DNA fragment having a sticky end of the present invention comprises: (i) a step of performing a PCR reaction using a template DNA and specific primers to obtain an amplified DNA fragment; and (ii) a step of performing a prescribed treatment on the amplified DNA fragment to dissociate a protecting group from the fragment. Herein, the above-mentioned specific primers are composed of a complementary DNA portion consisting of a nucleotide sequence complementarily binding to an amplification target region in a template DNA and a non-complementary DNA portion consisting of a nucleotide sequence that links to the 5′ end of the complementary DNA portion but does not complementarily bind to the amplification target sequence, and at least a base corresponding to the 3′ end in the nucleotide sequence of the non-complementary DNA portion is modified with a protecting group capable of terminating the progression of DNA replication catalyzed by a DNA polymerase. | 2011-01-13 |
20110009608 | AUTOMATIC REFINING APPARATUS, MULTI-WELL PLATE KIT AND METHOD FOR EXTRACTING HEXANE FROM BIOLOGICAL SAMPLES - The present invention relates to an automatic refining apparatus for separating target materials from a plurality of biological sample solutions by using magnetic particles to which the magnetic particles are to be reversibly coupled, and to a multi-well plate kit for use in the automatic refining apparatus. Further, the present invention relates to a method for extracting nucleic acids from biological samples by using the above-described automatic refining apparatus. The present invention can be used in the automatic separation of nucleic acid, protein, and the like from biological samples. | 2011-01-13 |
20110009609 | 2'-HYDROXY-PROTECTED RIBONUCLEOSIDE DERIVATIVE AND PRODUCTION METHOD THEREOF - The present invention relates to a method for producing a 2′-hydroxy-protected nucleoside derivative by reacting a ribonucleoside with an acylating reagent in the presence of a metal complex consisting of a copper compound and an optically active ligand. By the method according to the present invention, a 2′-hydroxy-protected ribonucleoside derivative, which is an important intermediate for producing an oligonucleoside, can be easily produced with good regioselectivity from a nucleoside derivative of which 2′,3′-hydroxy groups are not protected. | 2011-01-13 |
20110009610 | Process For The Acetylation Of Lignocelluloses, Hemicelluloses, and Celluloses With Ketene - The invention relates to a process for acetylating celluloses, lignocelluloses and hemicelluloses such as wood, straw and cotton, and regenerated celluloses produced from natural products, by means of ketene. | 2011-01-13 |
20110009611 | CLARIFICATION OF SPHINGANS AND COMPOSITIONS THEREOF - The invention relates to mutant strains of the genus | 2011-01-13 |
20110009612 | AUTOMATED SOLUTION-PHASE ITERATIVE SYNTHESIS - The first method for iterative solution-phase biomolecule synthesis is described. The method requires only 3 or fewer equivalents of building block at each coupling cycle, and incorporates a FSPE step at the end of each coupling/deprotection sequence to eliminate most byproducts. | 2011-01-13 |
20110009613 | METHOD OF PROCESSING BETA-GLUCAN - The invention relates to a method of degrading plant-based β-glucan into a controlled molecular size by hydrolyzing β-glucan in a closed space under pressure by means of an acid at an elevated temperature. The invention also relates to a degraded β-glucan product. The β-glucan product obtained is useful in foodstuffs applications, such as beverages. | 2011-01-13 |
20110009614 | PROCESSES AND REACTOR SYSTEMS FOR CONVERTING SUGARS AND SUGAR ALCOHOLS - Processes and reactor systems are provided for the conversion of sugars to sugar alcohols using a hydrogenation catalyst, which includes apparatus and method for in-line regeneration of the hydrogenation catalyst to remove carbonaceous deposits. | 2011-01-13 |
20110009615 | METHOD FOR PRODUCING A STEROID COMPOUND - An object of the present invention is to provide a novel method for producing a steroid compound. The present invention provides a method for producing 3,7-dioxo-5β-cholanic acid or ester derivatives thereof, which uses, as raw materials, sterols having double bonds at positions 5 and 24, such as cholesta-5,7,24-trien-3β-ol, ergosta-5,7,24(28)-trien-3β-ol, desmosterol, fucosterol, or ergosta-5,24(28)-dien-3β-ol, and which comprises the following 4 steps: (I) a step of performing oxidation of a hydroxyl group at position 3 and isomerization of a double bond at position 5 to position 4; (II) a step of converting position 24 to a carboxyl group or an ester derivative thereof by the oxidative cleavage of a side chain; (III) a step of introducing an oxygen functional group into position 7; and (IV) a step of constructing a 5β-configuration by reduction of a double bond at position 4. | 2011-01-13 |
20110009616 | AGENT FOR PREVENTING ARTERIOSCLEROSIS - The invention provides antiarterioscierosis agents containing as the active ingredient porphyrin derivatives or ester derivatives thereof as represented by the general formula (1) or (2); and foods or pharmaceutical compositions containing the agents. The porphyrin derivatives and the ester derivatives thereof exhibit an effect of inhibiting the bonding of oxidized LDL to LOX-1 expressed in vascular endothelial cells, macrophage an so on and an antagonistic effect of inhibiting the incorporation of oxidized LDL into cells through LOX-1, and are highly safe. [Chemical formula 1] (wherein R1 and R2 are each a hydrocarbon group having 1 to 4 carbon atoms or the like; and R3 to R8 are each a hydrocarbon group having 1 to 2 carbon atoms, formyl, or the like) [Chemical formula 2] (wherein R1 and R2 are each a hydrocarbon group having 1 to 4 carbon atoms or the like; and R3 to R8 are each a hydrocarbon group having 1 to 2 carbon atoms, formyl, or the like) | 2011-01-13 |
20110009617 | Ruthenium Catalysts and Uses Thereof - Ruthenium nanoparticles supported on non-cross-linked soluble polystyrene were prepared by reacting [RuCl | 2011-01-13 |
20110009618 | METHODS OF MANUFACTURING CRYSTALLING FORMS OF RAPAMYCIN ANALOGS - A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split. | 2011-01-13 |
20110009619 | POLYCYCLIC COMPOUND - Disclosed is a compound represented by the formula (I): | 2011-01-13 |
20110009620 | 4-Amino-5-cyanopyrimidine derivatives - The present invention provides 4-amino-5-cyanopyrimidine derivatives of the formula: wherein R | 2011-01-13 |
20110009621 | SUPPORTED TRANSITION METAL COMPLEX AND USE THEREOF IN CATALYSIS - The invention relates, in particular, to supported transition metal complexes based on a polystyrene matrix comprising structural units of the formula (Ia): | 2011-01-13 |
20110009622 | LONG-CHAIN FATTY ACYL ELONGASE INHIBITOR COMPRISING ARYLSULFONYL DERIVATIVE AS ACTIVE INGREDIENT - [Problem] To provide compounds useful as preventives or remedies for circular system disorders, nervous system disorders, metabolic disorders, reproduction system disorders, digestive system disorders, neoplasm, infectious diseases, etc., or as herbicides. | 2011-01-13 |
20110009623 | SELECTIVE GROWTH OF STABLE POLYMORPHS - Methods and an apparatus for producing stable crystal polymorphs are provided. Inner surfaces of glass vials with a concave bottom topography are coated with nonstick compounds to select for nucleation of stable polymorphs. | 2011-01-13 |
20110009624 | BENZIMIDAZOLE COMPOUNDS HAVING GASTRIC ACID SECRETION INHIBITORY ACTION - The present invention provides a compound that has superior gastric acid secretion inhibitory action, ample long-lasting gastric acid secretion inhibitory action, and is able to maintain intragastric pH at a high level for an extended period of time, making it useful as a therapeutic or prophylactic agent for diseases or symptoms caused by gastric acid, as well as an active form of this compound (form to which the compound is converted in the body following administration thereof) in the form of a compound represented by general formula (1a) (wherein R2 represents a group represented by formula (I) or the like, and R1, R3, W1 and X | 2011-01-13 |
20110009625 | NOVEL COMPOUNDS - Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors. | 2011-01-13 |
20110009626 | AMINOQUINOLINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS - The present invention relates to an adenosine A | 2011-01-13 |
20110009627 | REACTOR FOR CARRYING OUT HIGH PRESSURE REACTIONS, METHOD FOR STARTING AND METHOD FOR CARRYING OUT A REACTION - The invention relates to a reactor for performing high-pressure reactions, comprising at least one tube ( | 2011-01-13 |
20110009628 | Compounds and Compositions for Modulating Lipid Levels and Methods of Preparing Same - The present technology relates to compounds of Formulas I-VI and methods of making and using such compounds. Methods of use include prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome. Compounds disclosed herein also increase HDL-C, lower total cholesterol, LDL-cholesterol, and triglycerides and increase hepatic LDL receptor expression, inhibit PCSK9 expression, and activate AMP-activated protein kinase. | 2011-01-13 |
20110009629 | PREPARATION OF MORPHOLINE DERIVATIVES - This invention relates to processes and intermediates for the stereoselective morpholine derivatives. The invention in particular allows the stereoselective preparation of the drugs aprepitant and fosaprepitant. | 2011-01-13 |
20110009630 | PROCESS FOR THE PREPARATION OF MELAMINE - The present invention relates to a non-catalytic process for the preparation of melamine comprising: a) reacting molten urea in a reaction section at a pressure of 4.5 to 15 MPa to produce a reaction mixture containing molten melamine and reaction off-gases; b) vaporizing the molten melamine in said reaction mixture in a vaporization section to produce a gaseous mixture comprising the vaporized melamine and the reaction off-gases at a pressure of 4.5 to 15 MPa; c) quenching the gaseous mixture obtained from step b) by contact with an aqueous ammonium carbamate solution; and d) isolating melamine; and to a combined process for the preparation of urea and melamine, wherein melamine is prepared in accordance to the above method wherein at least part of the concentrated aqueous ammonium carbamate solution is transferred to an urea plant as at least part of the feed stock, urea is prepared utilizing said concentrated aqueous carbamate solution and urea obtained from said preparation step is supplied in molten form to the reacting step a). | 2011-01-13 |
20110009631 | Phenethanolamine Derivatives for Treatment of Respiratory Diseases - Compounds of the formula (II) and (IV) are provided, which may be employed as intermediates for making compounds useful in treating respiratory diseases. | 2011-01-13 |
20110009632 | IZM-3 CRYSTALLINE SOLID AND A PROCESS FOR ITS PREPARATION - A crystalline solid designated IZM-3 is described which has the X ray diffraction diagram given below. Said solid has a chemical composition expressed as the anhydrous base in terms of moles of oxides by the formula aSiO | 2011-01-13 |
20110009633 | Method for the Enrichment of Buprenorphine using Chromatographic Techniques - The present invention provides processes for the enrichment of buprenorphine in a product. In particular, the present invention provides processes for the enrichment of buprenorphine in a product using chromatographic techniques. | 2011-01-13 |
20110009634 | PROCESS FOR PREPARING OXYMORPHONE - Methods are provided which include converting oripavine to other opiates, including converting oripavine to 14-hydroxymorphinone and/or converting 14-hydroxymorphinone to oxymorphone. Purification and salt formation are optionally included. | 2011-01-13 |
20110009635 | NOVEL NITROGEN-CONTAINING ORGANIC COMPOUNDS USABLE AS CATALYTIC COMPOSITION PRECURSORS - The present invention describes novel nitrogen-containing organic compounds obtained by reacting a compound X of substituted pyridine type comprising at least one ketone function with a compound Y belonging to the aminoquinoleine family and derivatives thereof. Said organic compounds can be used as precursors in a catalytic composition. | 2011-01-13 |
20110009636 | PROCESS FOR THE PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS - The present invention relates to a process for preparing 2-methyl-2′-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefor. According to the present invention, pharmaceutically useful 2-methyl-2′-phenylpropionic acid derivatives can be prepared with high yield and purity on industrial scale. | 2011-01-13 |
20110009637 | Crystals of Dexlansoprazole - The present invention relates to crystals of the Active Pharmaceutical Ingredient (API) Dexlansoprazole, including methods of making the crystals, pharmaceutical compositions comprising the crystals, and methods of treating a patient with the crystals. | 2011-01-13 |
20110009638 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES - Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M | 2011-01-13 |
20110009639 | SYNTHESIS OF ENONE INTERMEDIATE - The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides a more efficient route for preparing the enone intermediate. | 2011-01-13 |
20110009640 | BIFUNCTIONAL PHENYL ISO (THIO) CYANATES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION - A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent | 2011-01-13 |
20110009641 | Amine-containing lipids and uses thereof - Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. | 2011-01-13 |
20110009642 | Method for the Regioselective Synthesis of 1-Alkyl-3-haloalkyl-pyrazole-4-carboxylic Acid Derivatives - The present invention relates to a process for the regioselective synthesis of 1-alkyl-3-halo-alkylpyrazole-4-carboxylic acid derivatives by cyclization of 2,3-disubstituted acrylic acid derivatives, and to the hydrazones formed as intermediates in the process. | 2011-01-13 |
20110009643 | METHOD FOR PRODUCING ACRYLATE DERIVATIVE, ACRYLATE DERIVATIVE, AND INTERMEDIATE THEREOF - Provided are 1) a production process for an acrylic ester derivative capable of being a raw material of a polymer for obtaining a photoresist composition capable of forming a photoresist film which is excellent in a reactivity to acid and a heat stability and is less swollen in developing and which has a refractive index of preferably 1.72 or more in 193 nm and can be patterned, 2) an acrylic ester derivative obtained by the above production process and 3) alcohol and ester which are synthetic intermediates for the above acrylic ester derivative. | 2011-01-13 |
20110009644 | PROCESS FOR PREPARING FLUORINATED 1,3-DIOXOLAN 2-ONE - The present invention provides a process for preparing fluorinated 1,3-dioxolan-2-one by reacting a derivative of 1,3-dioxolan-2-one having halogen atom other than fluorine with an amine hydrofluoride in an organic solvent, and in this preparation process, fluorinated 1,3-dioxolane-2-on can be prepared in a short period of time by liquid-liquid reaction while maintaining high yield, by using a derivative of 1,3-dioxolan-2-one having halogen atom other than fluorine as a starting material and fluorinating the derivative with a fluorinating agent. | 2011-01-13 |
20110009645 | MEMBRANE SEPARATION METHOD FOR SEPARATING HIGH BOILER DURING THE PRODUCTION OF 1,3-DIOXOLANE-2-ONES - The present invention relates to a process for the continuous preparation of a 1,3-dioxolan-2-one wherein a discharge from the reaction zone is subjected to a fractionation by means of a semipermeable membrane in order to separate off polymeric by-products. | 2011-01-13 |
20110009646 | RUTHENIUM-DIAMINE COMPLEX AND METHODS FOR PRODUCING OPTICALLY ACTIVE COMPOUNDS - There are provided a novel ruthenium-diamine complex, and methods for selectively producing an optically active alcohol and an optically active amine, which are important as precursors for the synthesis of medicinal drugs and functional materials, using the ruthenium-diamine complex as a catalyst. | 2011-01-13 |
20110009647 | Process 054 - The present invention is directed to a process for the preparation of a diastereomerically pure dibenzoyl-L-tartrate salt of a compound of formula (III) | 2011-01-13 |
20110009648 | Carbonyl Asymmetric Alkylation - This invention relates to processes and intermediates for the stereoselective alkylation of carbonyl groups. The invention in particular allows the stereoselective preparation of the antidepressant drug escitalopram. It has been found that boric or boronic acid derivatives are useful bridging elements for the attachment of a chiral group to a compound containing a carbonyl group to be alkylated. The said borates and boronates are thus useful in a process for the asymmetric alkylation of a carbonyl group in a compound containing a carbonyl group and an anchor group capable of reacting with a boric or boronic acid derivative. The asymmetric alkylation can be carried out by admixing the compound containing a carbonyl group to be alkylated and the anchor group capable of reacting with a boric or boronic acid derivative with a boric or boronic acid derivative, adding a chiral alcohol, and adding an organometallic compound. After the alkylation reaction, the borate and boronate can be easily removed by hydrolysis. | 2011-01-13 |
20110009649 | METHOD FOR PREPARING 2-(n-BUTYL)-5-NITROBENZOFURAN - A method for preparing 2-(n-butyl)-5-nitrobenzofuran from 1-halo-4-nitrobenzene, characterized in that 1-hexen-3-ol is reacted, and then the product is subject to a Claisen rearrangement, followed by catalytic intramolecular cyclization. | 2011-01-13 |
20110009650 | METHOD FOR PRODUCING CHIRAL ALPHA,BETA-EPOXY KETONES - A process is claimed for the enantioselective epoxidation of α,β-unsaturated ketones, in which a compound of the general formula I, | 2011-01-13 |
20110009651 | REGENERATION METHOD OF TITANOSILICATE CATALYST - The present invention provides a regeneration method of a titanosilicate catalyst, specifically provides a regeneration method of a titanosilicate catalyst which comprises contacting the titanosilicate catalyst deteriorated in catalytic ability with a nitrile compound or a mixture of water and a nitrile compound at a temperature from 25° C. to 200° C. | 2011-01-13 |
20110009652 | PROCESS FOR PRODUCTION OF EPOXY COMPOUND - A novel process for producing a polyfunctional epoxy monomer is provided that facilitates separation of an aqueous layer catalyst from a reaction solution and has satisfactory hydrogen peroxide efficiency by reacting an aqueous hydrogen peroxide solution with a polyolefin without using an organic solvent and under mild conditions. The process in the present invention is a process for producing a corresponding epoxy compound by reacting an organic compound having a carbon-carbon double bond with hydrogen peroxide present in an aqueous hydrogen peroxide solution to epoxidate the double bond, wherein a tungsten compound and tertiary amine are used as reaction catalysts. | 2011-01-13 |
20110009653 | PROCESS FOR MAKING ETHYLENE OXIDE USING MICROCHANNEL PROCESS TECHNOLOGY - This invention relates to a process comprising reacting ethylene and oxygen or a source of oxygen in a process microchannel in the presence of a catalyst to form a product comprising ethylene oxide. | 2011-01-13 |
20110009654 | 11B-FLUORO-3-ACETOXYESTRA-3,5-DIEN-17-ONE AND METHOD FOR THE PRODUCTION THEREOF - The present invention relates to 11β-fluoro-3-acetoxyestra-3,5-dien-17-one as a suitable intermediate in the preparation of 11-fluoro-substituted steroids and to the process for preparation thereof. For this purpose, 11α-hydroxyestra-4-ene-3,17-dione is reacted with 1 to 3 equivalents of n-nonafluorobutanesulfonyl fluoride and 3 to 5 equivalents of diazabicycloundecene (DBU) at −40 to −20° C. in an organic aprotic solvent and, after an aqueous workup, reacted with 5 to 10 equivalents of acetic anhydride and 0.01 to 1 equivalent of a strong acid. The desired product precipitates spontaneously out of the reaction solution and is obtained in a very high purity by filtration. The process is notable for the very high yield, avoidance of a chromatographic purification of the product, a reduced proportion of wastes and significantly increased process throughput. The process according to the invention is therefore especially suitable for preparing 11β-fluoro-3-acetoxyestra-3,5-dien-17-one on a large industrial scale. | 2011-01-13 |
20110009655 | NOVEL ATP:CITRATE LYASE GENES - The present invention provides novel genes for ATP:citrate lyase. | 2011-01-13 |
20110009656 | METHOD OF SURFACE MODIFICATION OF METALLIC HYDRIDE FORMING MATERIALS - The invention discloses a method of modifying the surface of a metallic hydride-forming material, through functionalization treating the surface of the metallic hydride-forming material with aminosilane to deposit self-assembled monolayers onto the surface. Thereafter at least one Platinum Group Metal is deposited onto the treated surface of the metallic hydride-forming material to allow chemical bonding to occur between the Platinum Group Metal(s) and the self-assembled monolayers. | 2011-01-13 |
20110009657 | Method for the Synthesis of a Rare-Earth Organophosphate and Use Thereof for Preparing a Preformed Catalytic System - A process for preparing a rare-earth organophosphate in the form of a gel that can be used as is for the preparation of a “preformed” catalyst system intended, in particular, for the cis-1,4 stereospecific polymerization of conjugated dienes. | 2011-01-13 |
20110009658 | Mono Ethylenically Unsaturated Polycarbosiloxane Monomers - The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain monoethylenically unsaturated polycarbosiloxane monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. | 2011-01-13 |
20110009659 | METHOD FOR PRODUCING ALKYL CHLOROSILANES FROM THE RESIDUES OF THE DIRECT SYNTHESIS OF ALKYL CHLOROSILANES - High boiling residue from the direct synthesis of alkylchlorosilanes are converted in large part to monosilanes by heating the residue by passage of alternating current in a pressurized reactor. | 2011-01-13 |
20110009660 | Process for the removal of HF from HF containing organic carbonates - Mixtures comprising organic carbonates, such as carbonates not substituted by fluorine, but especially fluorosubstituted organic carbonates, which are depleted in HF can be obtained from respective mixtures with a higher HF content by a step of stripping such mixture with an inert gas. For example, a reaction mixture comprising fluoroethylene carbonate and HF can be treated in this way. The mixture comprising organic carbonate which is depleted in HF can be distilled to obtain highly purified organic carbonate. | 2011-01-13 |
20110009661 | COMPOUND HAVING ALICYCLIC STRUCTURE, (METH)ACRYLIC ACID ESTER, AND PROCESS FOR PRODUCTION OF THE (METH)ACRYLIC ACID ESTER - Provided are an alicyclic structure-containing compound, a (meth)acrylate, and a method for producing the ester. The compound and the ester are useful as a monomer and the like for a photoresist used in semiconductor manufacturing and excellent in solubility, compatibility, defect reduction, roughness improvement, and the like, realized by using an alicyclic structure-containing compound containing a linking group having an ester bond and/or a linking group having an ether bond, a (meth)acrylate derived from the alicyclic structure-containing compound, and a method for producing the ester. | 2011-01-13 |
20110009662 | PROCESS FOR PRODUCING PHOSPHORUS-CONTAINING DEHYDROAMINO ACID - A process for efficiently producing through a small number of steps an N-substituted 2-amino-4-(substituted-oxymethylphosphinyl)-2-butenoic ester which is an intermediate for herbicide L-AMPB. The process comprises reacting a compound represented by the following formula (1): (where R | 2011-01-13 |
20110009663 | PROCESS FOR PURIFYING AN a-KETO ESTER - Process for purifying an α-keto ester by removing secondary and tertiary alcohols from the α-keto ester. In a first step, the α-keto ester to be purified is treated with a carboxylic anhydride and an acid, which is essentially insoluble under the filtration conditions, to esterify the secondary and tertiary alcohols. Subsequent filtration to remove the acid followed by distillation affords the desired purified α-keto ester. | 2011-01-13 |
20110009664 | METHOD FOR PREPARING OPTIONALLY SUBSTITUTED P-HYDROXYMANDELIC COMPOUNDS AND DERIVATIVES THEREOF - The invention relates to a method for preparing optionally substituted P-hydroxymandelic compounds and derivatives thereof. The method for preparing the mandelic compounds of the invention comprises condensing in water, in the presence of an alkaline agent, an aromatic compound bearing at least one hydroxyl group and having a free para position, with glycoxylic acid, wherein said method is characterised in that said reaction is carried out in a piston-flow reactor. | 2011-01-13 |
20110009665 | Acetic acid production by way of carbonylation with enhanced reaction and flashing - A method of making acetic acid includes: (a) catalytically reacting methanol or a reactive derivative thereof with carbon monoxide in the presence of a homogeneous Group VIII metal catalyst and a methyl iodide promoter in a reactor vessel in a liquid reaction mixture including acetic acid, water, methyl acetate, methyl iodide and homogeneous catalyst, the reactor vessel being operated at a reactor pressure; (b) withdrawing reaction mixture from the reaction vessel and feeding the withdrawn reaction mixture along with additional carbon monoxide to a pre-flasher/post reactor vessel operated at a pressure below the reactor vessel pressure; (c) venting light ends in the pre-flasher vessel and concurrently consuming methyl acetate in the pre-flasher/post reactor vessel. Reaction conditions, residence time and composition are controlled in the pre-flasher/post reactor vessel such that a pre-flash mixture is enriched in acetic acid and diminished in methyl iodide and methyl acetate in the pre-flasher/post reactor vessel. From the pre-flasher/post reaction vessel the acetic acid enriched mixture is (d) withdrawn and fed to a flash vessel. | 2011-01-13 |
20110009666 | Oxidation catalyst and its preparation - Process for the selective oxidation of ethane to ethylene and/or acetic acid, and/or the selective oxidation of ethylene to acetic acid, by contacting ethane and/or ethylene with a molecular oxygen-containing gas at elevated temperature in the presence of a spray-dried supported catalyst composition. The supported catalyst composition includes molybdenum, vanadium and niobium metal components, supported on a support comprising alpha-alumina. The supported catalyst is prepared by forming a slurry of the metal components and alpha-alumina support particles or an alpha-alumina support precursor, and spray-drying the slurry. | 2011-01-13 |
20110009667 | Use of Chemical Reaction to Separate Ethylene FromEthane in Ethane-Base Processes to Produce Acetic Acid - Described herein is a process in which acetic acid is produced by ethane oxidation. One byproduct of the ethane oxidation is ethylene. High ethylene content in the recycle gas stream will lead to poor efficiencies and higher losses to the COx byproduct in the acetic acid reactor. In fact, ethylene in the recycle feed competes with the ethane for the limited amount of oxygen feed, resulting in higher inefficiencies to carbon oxides than straight ethane oxidation. Ethylene is removed in this process by a further oxidation reaction at a temperature low enough such that ethane is not reactive, but the ethylene is converted to acetic acid. Either the ethane oxidation reactor effluent or a portion or all of the recycle stream to the ethane oxidation reactor, or any combination of the same, can be processed in this manner to reduce the ethylene content of those streams. | 2011-01-13 |
20110009668 | POLYFLUOROSULFONAMIDO AMINE AND INTERMEDIATE - Current methods for making polyfluorosulfonamido amines, which involve the use of a diamine reactant, provide low yields and produce an undesirable fluorine containing bis-sulfonamide by-product representing an economic loss. The bis-sulfonamide by-product is particularly undesirable because it shares very similar physical properties with the desired monoamine product thus making isolation of the desired polyfluorosulfonamido amine product difficult and costly. Furthermore, instead of the efficient incorporation of fluorine to make the desired polyfluorosulfonamido amine product, the bis-sulfonamide by-product constitutes a substantial loss of costly fluorinated starting material. The bis-sulfonamide by-product also constitutes an undesirable impurity that can worsen surfactancy, repellency, or other performance characteristics of the desired polyfluorosulfonamido amine product. The present invention provides a method of making a polyfluorosulfonamido amine without the production of a bis-sulfonamide by-product by reacting a polyfluoroalkylsulfonic compound with a monoamino amide rather than with a diamine reactant as in previously known methods. | 2011-01-13 |
20110009670 | CYCLOHEXANEDIMETHANAMINE BY DIRECT AMINATION OF CYCLOHEXANEDIMETHANOL - Embodiments of the present invention include methods for producing a cyclohexanedimethanamine by a reductive amination process. | 2011-01-13 |
20110009671 | PROCESS FOR PREPARING A PRIMARY AMINE WITH A TERTIARY ALPHA CARBON ATOM BY REACTING A TERTIARY ALCOHOL WITH AMMONIA - A process for preparing a primary amine with a tertiary alpha-carbon atom by reacting a tertiary alcohol with ammonia in the presence of a heterogeneous catalyst, by performing the reaction in the presence of a non-microporous, non-zeolitic aluminosilicate as a catalyst, where the aluminosilicate has a molar Al/Si ratio in the range from 0.1 to 30. | 2011-01-13 |