03rd week of 2022 patent applcation highlights part 36 |
Patent application number | Title | Published |
20220018787 | ATMOSPHERIC AEROSOL INVERSION BASED ON STATISTICAL AND OTSU SEGMENTATION - Embodiments include a method for retrieving atmospheric aerosol based on statistical segmentation. Firstly a multi-band remote sensing image including an apparent reflectance and an aerosol optical thickness look-up table corresponding to a retrieval band is obtained, then pixels are partitioned and screened according to apparent reflectance segments of a mid-infrared 2.1 micrometer band. After that the retained pixel sets are further partitioned and screened according to the apparent reflectance segments of the mid-infrared 1.6 micrometer band. Finally the obtained pixel sets are partitioned into two categories according to the pixel number, one category including pixels having more pixels, the other including those with less pixels. The category with more pixels is taken as the reference part for retrieval. | 2022-01-20 |
20220018788 | WAFER AND METHOD FOR ANALYZING SHAPE THEREOF - Disclosed is a method for analyzing a shape of a wafer. The method includes measuring external shapes of a plurality of wafers, detecting a first point having a maximum curvature in an edge region of each wafer from measured values acquired in the measuring the external shapes of the wafers, detecting a second point spaced apart from the first point in a direction towards an apex of a corresponding one of the wafers, measuring a first angle formed between a first line configured to connect the first point and the second point and a front side of the corresponding one of the wafers, forming a thin film layer on a surface of each wafer, measuring a thickness profile of the thin film layer, and confirming a wafer in which a maximum value of the thickness profile of the thin film layer is the smallest among the wafers. | 2022-01-20 |
20220018789 | METHOD FOR INSPECTING A SEMICONDUCTOR ELEMENT AND INSPECTION APPARATUS FOR EXECUTING THE SAME - A method for inspecting a semiconductor element includes steps of: a) providing an inspection apparatus including a supporting unit that includes a central seat and a plurality of positioning plates, and a camera unit that includes a first image capture device; b) positioning the semiconductor element onto the positioning plates; c) capturing a first bottom image of the semiconductor element; d) generating relative movement between the semiconductor element and the positioning plates; e) capturing a second bottom image of the semiconductor element; and f) synthesizing the first bottom image and the second bottom image to obtain a complete bottom image of the semiconductor element. | 2022-01-20 |
20220018790 | ABNORMALITY DETECTING METHOD AND ABNORMALITY DETECTING APPARATUS - An abnormality detecting method includes: generating substrate information that represents a relationship between an in-plane position of a substrate processed in a semiconductor manufacturing apparatus and a film characteristic; and determining whether the film characteristic of the processed substrate is abnormal, based on the substrate information generated in the generating, and association information in which substrate information and abnormality factors are associated with each other. | 2022-01-20 |
20220018791 | SINGLE-CRYSTAL X-RAY STRUCTURE ANALYSIS APPARATUS AND METHOD, AND SAMPLE HOLDER THEREFOR - A single-crystal X-ray structure analysis apparatus capable of surely and easily performing a single-crystal X-ray structure analysis using a crystalline sponge, an analysis method and a sample holder thereof, are provided. There are provided a sample holder | 2022-01-20 |
20220018792 | OPTICAL DEVICES AND METHOD OF OPTICAL DEVICE METROLOGY - Embodiments of the present disclosure relate to optical devices having one or more metrology features and a method of optical device metrology that provides for metrology tool location recognition with negligible impact to optical performance of the optical devices. The optical device includes one or more target features. The target features described herein provide for metrology tool location recognition with negligible impact to optical performance of the optical devices. In metrology processes, the target features allow for metrology tools to determine one or more locations of the optical device having a macroscale surface area. The target features correspond to one or more structures merged together, one or more structures merged together surrounded by one or more structures that have been removed, or one or more structures that have been removed having one or more profiles defined by adjacent structures to the target features. | 2022-01-20 |
20220018793 | SENSING OF A VAPOR QUALITY - The invention relates to a sensor arrangement for providing a sensor signal S indicative of a vapor quality X of a medium flowing within a conduit | 2022-01-20 |
20220018794 | CONTACT-TYPE DETECTION ELECTRODE AND MOVABLE ELECTRIC DEVICE - A contact-type detection electrode for detecting dispersible dirt and a movable electric device are provided. The contact-type detection electrode includes a support, and electrical conductors arranged on the support and being flexible. | 2022-01-20 |
20220018795 | METHOD FOR DETERMINING A NICOTINE CONTENT IN A GAS MIXTURE - A method for determining a nicotine content in a gas mixture. The method includes exposing a metal oxide-based sensor to the gas mixture, applying a temperature profile over time to the metal oxide so that the temperature of the metal oxide, proceeding from a predetermined first temperature level, is brought to a predetermined second temperature level under controlled first transition conditions, and the temperature is brought from the second temperature level to a third predetermined temperature level under controlled second transition conditions, ascertaining a transient specific electrical resistance of the metal oxide at at least one certain point in time during the application with the temperature profile, and determining the nicotine content based on the ascertained resistance. A processing unit and a computer program product for carrying out the method are also described. | 2022-01-20 |
20220018796 | SENSOR AND METHOD FOR OPERATING SENSOR - The present invention provides a sensor comprising: a substrate; an antenna pattern formed in a spiral shape on the substrate; first and second electrodes formed on the substrate and spaced apart from each other in parallel; a circuit wiring formed to be connected to each of the first and second electrodes; and an element bonded to the antenna pattern and the circuit wiring, wherein cross sections of the first and second electrodes have a curvature. | 2022-01-20 |
20220018797 | RAPID AIRBORNE VIRAL SENSOR AND METHODS RELATED THERETO - The present invention provides for a device and method for the rapid detection (within seconds) of viruses and virions (proteins and nucleic acids) found in novel coronavirus (SARS-CoV-2) and other viruses through testing of an air sample. The device can be used at front line, hospitals, clinical laboratories, airports, groceries, homes, and the like. The device can be used as a single probe for single use or home use for fast detection of multiple samples simultaneously. The present invention would facilitate multiple testing at times of pandemics caused by airborne viruses when a large number of samples have to be tested in short periods of time. | 2022-01-20 |
20220018798 | BINDING PROBE CIRCUITS FOR MOLECULAR SENSORS - In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and a binding probe molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the binding probe. In various examples, the binding probe is an antibody, the Fab domain of an antibody, a protein, a nucleic acid oligomer hybridization probe, or an aptamer. The circuit may further comprise molecular arms used to wire the binding probe to the electrodes. In various embodiments, the circuit functions as a sensor wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as targets interact with the binding probe. In various embodiments, the circuit provides a means to measure the presence, absence, or concentration of an analyte in a solution. | 2022-01-20 |
20220018799 | SYSTEM AND METHODS FOR MEASURING ANALYTE CONCENTRATION - A multiplex aptamer sensor platform for determining the concentration of a target analyte in sample. Aptamers are modified with redox-active molecule and selected to exhibit conformational change in the presence of target analyte, so that faradic discharge can be sampled at the electrode surface. Faradic discharge is converted to digital signal for calculation of the analyte concentration. The platform is attached to a test cartridge utilizing a vertical connection to a reader device. Sensor electrodes are manufactured using PCB techniques yet the platform is both accurate and commercially usable. No mixing, microfluidics or calibration are required. | 2022-01-20 |
20220018800 | DEVICE FOR SIMULTANEOUS AND RAPID DETERMINATION IN SALIVA OF THE FERTILITY HORMONES ESTRADIOL, PROGESTERONE, LUTEINIZING HORMONE AND PROLACTIN - Device for simultaneous and rapid determination of the fertility hormones estradiol, progesterone, luteinizing hormone and prolactin in saliva comprising a biosensor ( | 2022-01-20 |
20220018801 | Nanostructured Model Devices of Making and Applications in Monitoring of Energy Landscapes of Toxic Protein Refolding Thereto - Nanostructured model device of energy sensing and monitoring apparatus comprises arrays of orderly nanotubes parallel oriented forming 3D cross-bar with vertically oriented nanopillars membrane through self-assembly affixed onto an electrode; the membrane comprises active sites of an innate Heat Shock Protein (HSP) cross-linked with conductive polymers on an electrode to be able to monitor toxic protein β-amyloid (Aβ) energy landscape change, and the reversed membrane potential was restored in the presence of an antibiotic drug. By depositing the HSP60 polymer mixtures on a top of a MMP-2 membrane, it promoted a moonlighting protein network that was able to 97.3% impaired Aβ refolding with imprecision 0.05%, which was not depending on antibiotic drug's concentration, wherein to be able to maintain the RMP. | 2022-01-20 |
20220018802 | pH MEASURING DEVICE AND pH MEASURING METHOD - A pH measuring device configured to measure a pH of a target liquid includes a main body block including a cavity, a supply line communicating with the cavity, a first drain line communicating with the cavity, and a target liquid supply valve configured to adjust a supply of the target liquid into the supply line. The main body block has an integral structure in which a pH sensor is supported such that the pH sensor is in contact with the target liquid within the cavity. | 2022-01-20 |
20220018803 | GAS SENSOR - A gas sensor includes a sensor element that has an atmospheric-air introduction path into which atmospheric air is introduced. The sensor element includes a solid electrolyte body, an insulating body, an exhaust electrode, and an atmosphere electrode. The solid electrolyte body has ion conductivity. The insulating body is laminated onto the solid electrolyte body. The exhaust electrode is provided in the solid electrolyte body and exposed to an exhaust gas. The atmosphere electrode is provided in a position that opposes the exhaust electrode in the solid electrolyte body. The atmosphere electrode is used so as to be paired with the exhaust electrode, and is exposed to atmospheric air. The atmospheric-air introduction path is formed to house the atmosphere electrode in a section of the insulating body that opposes the solid electrolyte body. The atmospheric-air introduction path is provided with a trap layer for capturing toxic substances in the sensor element. | 2022-01-20 |
20220018804 | GAS SENSOR AND METHOD FOR MANUFACTURING SAME - An oxygen sensor is provided in which an insulative coating using an exterior resin material made of insulative resin is applied to a self-heating oxygen sensor element made of a ceramic sintered body housed in a case, and in which waterproof cloths with air permeability are attached using resin adhesives so as to cover openings that connect to air holes on end parts of the case. This allows provision of a gas sensor for use both in air and in liquid having insulating property, waterproof property, and thermal safety. | 2022-01-20 |
20220018805 | ION-SENSITIVE FIELD EFFECT TRANSISTOR - An ISFET or ISFET-based sensor includes a source terminal, a drain terminal and a transistor channel between the source terminal and the drain terminal, where the ISFET or ISFET-based sensor also includes a fin extending between the source terminal and the drain terminal, the fin including the transistor channel, the fin having opposite sides with charge-sensitive surface for forming an interface with an analyte solution and an insulating barrier between the charge-sensitive surface and the transistor channel located centrally between the opposite sides of the fin, such that the transistor channel has a height-to-width ratio of at least 10. | 2022-01-20 |
20220018806 | CLOSED-LOOP PH CONTROL WITH DIFFERENTIAL SENSOR - Closed-loop systems and methods for controlling pH. The system includes a working electrode, a counter electrode, a reference electrode, a first ion-sensitive field-effect transistor (ISFET), a second ISFET, and an electronic controller. The working electrode, the counter electrode, the reference electrode, and a first sensing terminal of the first ISFET are immersible in an active solution. A second sensing terminal of the second ISFET is immersible in a reference solution. The electronic controller is configured to apply a first amount of current or voltage to the working electrode and determine a differential voltage between the first ISFET and the second ISFET. The electronic controller is also configured to set a second amount of current or voltage to reduce a difference between the differential voltage and a target voltage. The electronic controller is further configured to apply the second amount of current or voltage to the working electrode. | 2022-01-20 |
20220018807 | MICROORGANISM DETECTION APPARATUS USING DIELECTROPHORESIS FORCE - The present disclosure relates to a microorganism detection apparatus using a dielectrophoresis (DEP) force. A microorganism detection apparatus according to one embodiment of the present disclosure may include a detection unit that detects microbial particles using a DEP force corresponding to latex particles combined with the microbial particles | 2022-01-20 |
20220018808 | SMALL MOLECULE DETECTION IN NORMAL IONIC STRENGTH BUFFERS - A system for detecting target molecules includes a sample well defining a sensing region and two electrode regions, a sensor positioned in the sensing region and sensitized to the target molecules, an electrode positioned in each electrode region and configured to expose the sensor to a frequency-modulated electric field, and a detector configured to detect both an amplitude of oscillation of the sensor at a frequency of the modulated electric field and a direction of a displacement of the sensor. The sensing region defines a channel between the electrodes, and a ratio of a current density at a center of the sensing region to a current density at one of the electrodes is at least 2. The system allows detection of target molecules in a normal ionic strength buffer (e.g., having an ionic strength in a range of about 10 mM to about 1 M). | 2022-01-20 |
20220018809 | TUNNEL JUNCTIONS IN MICROFLUIDIC ARRAYS FOR MOLECULAR RECOGNITION - Embodiments of the present technology may allow for the analysis of molecules by tunneling recognition at a tunneling junction. A tunneling junction of the present technology can include an insulating layer between two electrodes. A voltage may be applied to the electrodes. When a molecule makes contact with both electrodes, the molecule allows current to tunnel through the molecule. The characteristics of the current may aid in identifying a portion of the molecule, for example, a particular nucleotide or base present in a nucleic acid molecule. Methods and systems for analysis of molecules are described. | 2022-01-20 |
20220018810 | CHARACTERIZING INTERNAL STRUCTURES VIA ULTRASOUND - The present disclosure provides for characterizing internal structures via ultrasound by inducing an ultrasonic test wave in a component; developing a test signature based on measured propagation of the ultrasonic test wave through the component; characterizing an internal feature of the component based a comparison between the test signature and a baseline signature for the component; and providing an indication of the internal feature as characterized. In some aspects, the ultrasonic test wave is induced by a laser inducer and/or received by a laser interferometer. The test signature includes one or more of: frequency responses, amplitude responses, and times of flight. The test signature can be used to identify changes in a component over time, verify similarity between different components, monitor thermal processes, and verify an identify of a component. | 2022-01-20 |
20220018811 | MACHINE LEARNING METHOD FOR THE DENOISING OF ULTRASOUND SCANS OF COMPOSITE SLABS AND PIPES - A technological solution for analyzing a sequence of noisy or incoherent ultrasound scan images of an asset that includes a composite material having internal defects or voids and diagnosing a health condition of a section of the asset. The solution includes receiving, by an input-output interface, an ultrasound scan image of the section of the asset that contains noise or incoherence resulting from signal attenuation due to the composite material in the section of the asset; preprocessing, by a denoising unit, the ultrasound scan image to remove the noise or incoherence and output a denoised ultrasound image; analyzing, by a machine learning platform, the denoised ultrasound scan image to detect any aberrations in the section; evaluating, by the machine learning platform, any detected aberrations; generating, by the machine learning platform, a degree of health of the section of the asset based on any detected aberrations; and generating, by an image rendering unit, an image rendering signal to cause a computer resource asset to display the denoised ultrasound scan image on a display device. | 2022-01-20 |
20220018812 | Method for Calculating Residual Stresses in the Seam Metal of Welded Pipeline Joints (Variants) - Methods for non-destructive testing of engineering materials. In one aspect, a method can be used to calculate residual longitudinal and annular welding stresses in welded joints and can be used to assess the quality of pipeline welds according to the criterion of the level of residual stresses and to determine the initial parameters for the pipeline strength calculation. In some aspects, the method enables independent calculation of the longitudinal and hoop residual stresses. Thus, the stresses can be calculated in the seam metal of the pipelines welds, where they reach their maximum values. The method can be used to test a pipeline section using an ultrasonic echo method to measure the propagation time for longitudinal waves and transverse waves polarized along and across the pipe axis. The measurement results define the distinguishing features of the stress state of a welded joint for a specific type of pipe by numerical modeling. | 2022-01-20 |
20220018813 | FIXING FORCE EVALUATION METHOD - The fixing force evaluation method of the present embodiment includes the natural frequency measurement step of measuring the natural frequency of the stator in which the tooth portions and the stator coil are fixed by the insulating paper, and the fixing force evaluation step of evaluating that the fixing force of the insulating paper is larger, when the natural frequency of the stator measured in the natural frequency measurement step is equal to more than a predetermined determination frequency, compared to when the natural frequency is lower than the determination frequency. Thus, since the fixing force of the insulating paper is evaluated in the fixing force evaluation step based on the natural frequency of the stator measured in the natural frequency measurement step, the fixing force of the insulating paper can be evaluated by measuring the natural frequency of the stator without destroying the stator. | 2022-01-20 |
20220018814 | COILED WIRE INSPECTION SYSTEM AND METHOD - A system and method of ultrasonically inspecting coiled wire includes a wire drawer, a first power feeder, an ultrasonic inspection device, and a re-coiler. The wire drawer receives wire that is unspooled from a first coil of wire that has not been internally inspected for defects. The wire is then fed through the first power feeder, which straightens the wire. The straightened wire is then fed through the ultrasonic inspection device to detect internal defects of the wire. The inspected wire is then re-coiled into a second coil of wire that has been ultrasonically inspected for internal defects. Accordingly, raw and uninspected wire coils can be continuously conditioned and inspected and then re-coiled, and may be certified for use in specific manufacturing processes, without having to inspect individual cut and separated sections of wire. | 2022-01-20 |
20220018815 | REMOVING PORTIONS OF UNDEFINED COMPOSITION FROM THE MOBILE PHASE - A fluid supply system, for supplying a mobile phase in a sample separation device for separating a fluidic sample in a separation path, includes a proportioning unit for proportioning multiple solvent components for composing the mobile phase, a fluid drive unit for driving the solvent components of the mobile phase, and a control unit for controlling the proportioning unit and the fluid drive unit so that an undefined portion of the mobile phase is removed from the mobile phase before delivering the mobile phase from the fluid drive unit to the separation path. | 2022-01-20 |
20220018816 | SYSTEM FOR FLUSHING A GAS-MEASUREMENT DEVICE FOR ANALYZING GAS FROM A WELL, AND RELATED METHODS - One or more embodiments of the present disclosure include a gas-analysis system. The gas-analysis system may include a first valve, a gas-measurement device, and a second valve. The first valve may be between a sample-gas line and a sample-gas outlet. The first valve may be configured to either allow or prevent gas movement between the sample-gas line and the sample-gas outlet. The gas-measurement device operatively coupled to a testing-gas line. The second valve may be between the sample-gas line, a flushing-gas inlet, and the testing-gas line. The second valve may be configured to allow gas movement from one of the sample-gas line or the flushing-gas inlet to the testing-gas line. | 2022-01-20 |
20220018817 | Chromatography Column and Method of Assembling the Same - Disclosed is a chromatographic separation column assembly ( | 2022-01-20 |
20220018818 | ANALYSIS CONTROL DEVICE, LIQUID CHROMATOGRAPHIC SYSTEM AND ANALYSIS EXECUTION METHOD - A first liquid sending controller of an analysis control device controls a first liquid sender such that a mobile phase is supplied to a fluorescence detector through an analysis column and a junction during an analysis of a sample. A sample introduction controller controls a sample introducer such that the sample is introduced into a mobile phase by the sample introducer at a position farther upstream than the analysis column during the analysis of the sample. The second liquid sending controller causes a second liquid sender to start supplying a fluorescent reaction liquid such that the fluorescent reaction liquid arrives at the junction later than a point in time at which supply of the mobile phase starts and before the sample introduced into the mobile phase arrives at the junction during the analysis of the sample. A generator generates a chromatogram based on an output signal of the fluorescence detector during the analysis of the sample. | 2022-01-20 |
20220018819 | SENSOR MODULE - Disclosed herein is a sensor module that includes a substrate having a top surface and a back surface, a sensor element mounted on the top surface of the substrate, an external terminal formed on the back surface of the substrate, and a case fixed to the substrate so as to cover the sensor element. The case has a top plate part having a plurality of through holes. The top plate part has a center area having no through holes and a through hole formation area having the plurality of through holes, the through hole formation area being positioned so as to surround the center area. | 2022-01-20 |
20220018820 | SENSOR AND SENSOR MODULE - According to one embodiment, a sensor includes a base body, and a first sensor part. The first sensor part includes fixed and movable electrode members, and first and second support members. The fixed electrode member includes a fixed electrode fixed to the base body. The movable electrode member includes a movable electrode. The movable electrode member includes first and second movable portions, and a third movable portion between the first and second movable portions. The first support member is fixed to the base body and connected with the first movable portion. The second support member is fixed to the base body and connected with the second movable portion. The first and second support members support the movable electrode member to provide a first gap between the fixed and movable electrode members. The fixed electrode member includes first, second, and third fixed electrode portions facing the movable portion. | 2022-01-20 |
20220018821 | OPTICAL SENSOR FOR SENSING HYDROGEN GAS AND HYDROGEN GAS DETECTION SYSTEM INCLUDING THE SAME - Embodiments relate to an optical sensor for sensing hydrogen gas, which includes an optical fiber through which light moves; a ferrule formed at one end of the optical fiber to surround the optical fiber; and a sensor module configured to form an interference wave according to a Fabry-Perot interferometer with respect to light that moves through the optical fiber, wherein the sensor module includes a sensing material that expands and contracts by reacting with hydrogen gas, and spectrum periodicity of the interference wave changes according to a volume change of the sensing material, and a hydrogen gas detection system including the optical sensor. | 2022-01-20 |
20220018822 | PROTECTIVE ENCLOSURE FOR GAS SENSORS - A small-sized, portable enclosure protects a gas sensor against degradation due to environmental exposure and changes in atmospheric conditions. The protective enclosure includes an inlet for introduction of a gas into the enclosure, an outlet for release of the gas upon completion of a sensing run, and a number of in-line filters that remove from the inflowing gas sample analytes, contaminants, and other materials that can compromise the integrity of the sensor or cause the sensor to degrade over time. The enclosure does not include any filters during the measurement phase of the sensing run in order to allow the gas sensor to accurately measure an unmodified gas mixture and/or analyte. | 2022-01-20 |
20220018823 | INFORMATION PROCESSING APPARATUS, CONTROL METHOD, AND NON-TRANSITORY STORAGE MEDIUM - An information processing apparatus ( | 2022-01-20 |
20220018824 | PREDICTIVE WATER CONDITION MONITORING - Techniques for predictive water condition monitoring are described herein. An aspect includes a method that includes monitoring, by one or more processors, at least one water sensor to establish a baseline of a water condition model and monitoring one or more water conditions. A predicted water condition is determined based on the water condition model and the one or more water conditions. An alert is transmitted to one or more devices based on determining that the predicted water condition indicates a predicted contaminant level above a threshold. | 2022-01-20 |
20220018825 | DETERIORATION ESTIMATION DEVICE, DETERIORATION ESTIMATION METHOD, AND NON-TRANSITORY STORAGE MEDIUM - A deterioration estimation device includes a storage device and an execution device. The storage device is configured to store mapping data defining a mapping that outputs an output variable indicating the degree of deterioration of oil when an input variable is input. The mapping includes, as the input variable, a color variable that is a variable indicating a color of the oil and a hydrogen ion variable that is a variable indicating a hydrogen ion concentration of the oil. The execution device is configured to execute an acquisition process that is a process of acquiring the input variable and a calculation process of inputting the input variable acquired through the acquisition process to the mapping to output a value of the output variable. | 2022-01-20 |
20220018826 | COLORIMETRIC PLASMONIC NANOSENSOR FOR DOSIMETRY OF THERAPEUTIC LEVELS OF IONIZING RADIATION - An apparatus includes a solution including a metallic compound, a surfactant, and an acid. The solution is substantially colorless. A container holds the solution. A radiated solution is formed when the solution receives a low dose of ionizing radiation | 2022-01-20 |
20220018827 | SOLUTION COLLECTION DEVICE WITH EVALUATION ELEMENT - A blood testing device for detecting hemolysis in a blood sample is described. The blood testing device comprises an housing for containing the blood sample. The housing has a treatment window and an optical zone formed therein. The blood testing device further includes an acoustic transducer positioned to selectively generate acoustic forces directed into the treatment window of the housing and a control unit for selectively actuating and deactuating the acoustic transducer to permit colorimetric analysis of plasma within the blood sample. | 2022-01-20 |
20220018828 | METHODS AND KIT FOR ASSAYING LYTIC POTENTIAL OF IMMUNE EFFECTOR CELLS - To overcome the difficulty in achieving a quantitative assessment of CTL function in clinical settings, the inventors aimed at developing a new method inspired by their knowledge of the CTL/tumor target biology and based on flow cytometry. In particular, to directly detect the earliest steps of tumor cell resistance to CTL attack at the lytic synapse the inventors developed a method to monitor CTL/tumor cells interaction in the presence of FM1-43, a fluorescent lipophilic dye that rapidly intercalates into lipid bilayer during the membrane turnover that accompanies plasma membrane reparation. This assay allows the inventors to measure reparative membrane turnover of tumor cells under CTL attack by FACS analysis at the whole tumor cell population level. They initially applied this approach to compare the response of melanoma cell (D10 cells) to CTL attack as compared to conventional target cells that are sensitive to CTL mediated cytotoxicity (EB V-transformed B cells, JY cells). The methodology allows to rapidly assessing the synaptic resistance of tumor target cells to CTL attack and the intrinsic capacity of CD8+CTL to efficiently kill their target cells. Thus, the present invention relates to methods and kit for assaying lytic potential of immune effector cells and uses thereof in diagnostic assays. | 2022-01-20 |
20220018829 | Methods and Compositions for Clinical Evaluation of Therapeutic Agents - Methods and kits are described for clinical evaluation of a therapeutic agent. In particular, an immune perturbation reflecting an immune response signature of a disease is induced in a healthy subject, and a therapeutic agent of interest is clinically evaluated in the healthy subject with the immune perturbation. | 2022-01-20 |
20220018830 | SAMPLE EXTRACTION AND TEST METHODS FOR DIAGNOSING CHRONIC WASTING DISEASE - A prion disease test kit is provided that allows for quick sample collection by an untrained individual and accurate testing of the sample in a lab, which is remote from the sample collection location. The prion disease test kit allows a lay person to easily collect tissue samples from the field and submit the collected tissue samples for prion disease testing, such as testing for chronic wasting disease, at a different location. | 2022-01-20 |
20220018831 | METHOD FOR ELIMINATING INTERFERENCE OF THEOPHYLLINE IN IMMUNOASSAY AND IMMUNOASSAY KIT - The disclosure relates to a method for eliminating interference of theophylline in immunoassay and an immunodetection kit. The method for eliminating interference of theophylline in immunoassay includes: performing an immunoassay in the presence of a theophylline interference-resistant agent, the theophylline interference-resistant agent having a final concentration of 0.1 mg/mL-100 mg/mL, and being selected as at least one component from a group consisting of free 6-mercaptopurine, 6-thioguanine, 8-azguanine, hypoxanthine, adenine, purine, 2,6,8-trioxypurine, adenine nucleotide, and adenosine. The method and the kit can effectively reduce interference of theophylline on immunoassay results. | 2022-01-20 |
20220018832 | Materials and Methods for Glycan Profiling - The invention aims to provide a non-destructive method of testing and analysing, amongst other things, cell types such as pluripotent cells, including differentiated cells and MSCs. The invention also aims to provide a non-destructive method to test and analyse the cell conditions, such as aging, activity, multipotency, differentiated directivity and effectiveness. Possibility of analysing cell types or cell conditions without destroying the cells by analyzing glycan profile, which is acquired from glycoconjugates secreted from cells in culture mediums, using microarrays with glycan binding protein, on the surface was discovered. | 2022-01-20 |
20220018833 | METHOD FOR RE-USING HAPTEN-COATED PROBE IN AN IMMUNOASSAY - The present invention is directed immunoassay methods, which re-use a hapten-immobilized test probe and reagents for quantitating an analyte in different samples, anywhere from about 3 to 20 times, while maintaining acceptable clinical assay performance. The methods use a dual antibody conjugate solution comprising an anti-hapten antibody and a capture antibody against the analyte in each cycle. After the completion of each cycle of reaction, the test probe is dipped in an acidic solution having pH about 1-4, to elute the immunocomplex formed on the probe and to regenerate the hapten-immobilized probe. The robustness of the hapten-coated solid phase allows utilization of multiple denaturation reagents for efficient elution of the immune complexes after each cycle without compromising the binding activity of the hapten on the solid phase. | 2022-01-20 |
20220018834 | Biosensor and Preparation Method Thereof - A biosensor with improved detection sensitivity of a target substance, a method for preparing a biosensor with improved detection sensitivity, and a method for detecting a target substance using the biosensor. | 2022-01-20 |
20220018835 | USE OF CD26 AND CD39 AS NEW PHENOTYPIC MARKERS FOR ASSESSING MATURATION OF FOXP3+ T CELLS AND USES THEREOF FOR DIAGNOSTIC PURPOSES - Among regulatory T cells, natural regulatory T cells (nTregs) ensure the control of self-tolerance and are currently tested in clinical trials in autoimmune diseases and allogeneic hematopoietic stem cell transplantation. Here the inventors show that based on CD39/CD26 markers, the human nTreg population is comprised of 5 major cell subsets each representing a distinct state of maturation. Phenotypic and genetic characteristics of the subsets illustrate the structural parental maturation between subsets which further correlates with expression of regulatory factors. Importantly, the inventors also show that blood nTreg CD39/CD26 profile, remaining constant over a 2year period in healthy persons but varying between individuals, represents a novel biomarker for monitoring chronic diseases, as illustrated in their preliminary study on AI (dermatomyositis, rheumatoid arthritis and leukemias). Accordingly, the present invention relates to the use of CD26 and CD39 as phenotypic markers for assessing maturation of natural Treg cells. | 2022-01-20 |
20220018836 | NON-LIVING SURROGATE INDICATORS AND METHODS FOR SANITATION VALIDATION - Systems, surrogates, indicators and methods for rapid assessment of sanitation processes are provided. Non-living and non-toxic surrogates applied to a platform or encapsulated in a biological material mounted to a platform are exposed to a sanitation process to be evaluated. Responses to sanitation are measured and quantified using FTIR and chemometrics including principal component analysis (PCA), partial least squares regression (PLSR), loading plots and predictive models. An artificial leaf platform with one or more types of surrogates on one surface and an anchor such as an adhesive film on a second surface is described. Surrogate types include nucleic acid, phage, yeast and algae surrogates. Surrogates may also be attached directly or through a polymer to the platform surface. Surrogates may also be encapsulated or attached to the outside of a biological carrier such as a yeast cell that is free or coupled to the platform. | 2022-01-20 |
20220018837 | Method for the Detection of Surface-Mounted Biological Materials and Pathogens - Methods and compositions for the detection of surface-mounted pathogens are described herein. Compositions include preparations comprising quantum dot-ligand conjugates, wherein the ligands target a specific pathogen to form a quantum dot-pathogen complex. Methods include the use of the preparations comprising the quantum dot-ligand conjugates. The preparations may be applied to a surface for the detection of a surface-mounted pathogen thereon via fluorescence, which may be detected by the naked eye or a simple fluorescence camera. | 2022-01-20 |
20220018838 | IMMUNOASSAY FOR SARS-COV-2 NEUTRALIZING ANTIBODIES AND MATERIALS THEREFOR - The present invention relates to the development of novel immunoassays for the detection of neutralizing antibodies and/or high avidity neutralizing antibodies to SARS-CoV-2 spike protein variants or fragments thereof and, optionally, one or more cytokine in patient samples. Novel multiplex and singleplex immunoassays for the detection of neutralizing antibodies and/or high avidity neutralizing antibodies to SARS-CoV-2 spike protein variants or fragments thereof and, optionally, one or more cytokine in patient samples are also provided. | 2022-01-20 |
20220018839 | Method And System For Virus And Protein-Antibody Interactions Detection And Monitoring Based On Optical Light Intensity And Electrical Parameters - A novel method of detecting and destroying viral transmissions such as SARS-CoV-2 transmission is described. The proposed technique uses a light source such as that from a smart phone and a mobile spectrophotometer to enable detection of proteins in solution. The technique allows for detecting soluble preparations of for example spike protein subunits from SARS-CoV-2, followed by detection of the actual binding potential of the spike protein with its host receptor, for example the angiotensin-converting enzyme 2 (ACE2) or other antigens or elements. The results are validated by showing that this method can detect antigen-antibody binding using two independent protein-antibody pairs. Finally, this technique is combined with DC bias to show that introduction of a current in the system can be used to disrupt the antigen-antibody reaction, suggesting that this technique can be a powerful means of disrupting virus transmission by destroying virus-receptor interactions. | 2022-01-20 |
20220018840 | SYSTEM AND METHOD FOR DETERMINING PRESENCE OF CERTAIN ATTRIBUTES IN A TEST ARTICLE - A method for evaluating a test article provided by a subject for an attribute, such as a medical, industrial, veterinary, agricultural, food, or other attribute, is provided. The design includes providing a cassette comprising at least one ligand selected to match the attribute, applying the test article provided by the patient to the at least one ligand of the cassette, transmitting light energy toward the test article applied to the at least one ligand, sensing optical attributes of light energy provided from the test article applied to the at least one ligand, and providing sensed attributes of the light energy sensed to an electronic device. | 2022-01-20 |
20220018841 | METHOD FOR MEASURING ENDOTOXIN - A method for rapidly and highly sensitively measuring endotoxin relies on an endotoxin-measuring agent, which includes a factor C derived from | 2022-01-20 |
20220018842 | A BIOMARKER FOR PREDICTING THE PROGNOSIS FOR AN ENDOMETRIAL CANCER PATIENT - An objective of the present invention is to provide a novel biomarker for predicting the prognosis of an endometrial cancer patient. A biomarker that comprises a claudin 6 protein or a peptide fragment thereof, or a transcription product of a claudin 6 gene or a nucleic acid fragment thereof is provided so as to predict the prognosis of an endometrial cancer patient. | 2022-01-20 |
20220018843 | GLYCOPROTEIN BIOMARKERS FOR ESOPHAGEAL ADENOCARCINOMA AND BARRETT'S ESOPHAGUS AND USES THEREOF - Disclosed are biomarkers for Barrett's esophagus and esophageal adenocarcinoma, and uses thereof, such as in methods for detecting the presence, and monitoring progression, of Barrett's esophagus and esophageal adenocarcinoma. Also disclosed are methods for treating and methods of monitoring the treatment of Barrett's esophagus and esophageal adenocarcinoma, as well as kits and compositions for use in such methods. | 2022-01-20 |
20220018844 | Method for Treating a Cancer Based on Inflammatory Subtype Thereof - Provided herein is a method for treating a cancer in a subject by quantitating the concentration of a soluble form of Semaphorin 4D (sSema4D) in a blood sample obtained from the subject and administering an immunotherapy when the blood concentration of sSema4D is below a threshold value of 155 ng/ml. Also provided is a method for determining the continued susceptibility of a tumor tissue to immunotherapy in a subject by identifying the inflammatory subtype of the tumor tissue from a blood sample from the subject and administering immunotherapy over at least one interval as long as the tumor tissue exhibits an inflamed subtype. | 2022-01-20 |
20220018845 | ARTICLES AND METHODS DIRECTED TO PERSONALIZED THERAPY OF CANCER - Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology. | 2022-01-20 |
20220018846 | COMPOSITIONS AND METHODS FOR CARRYING OUT ASSAY MEASUREMENTS - The present disclosure provides compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the disclosure relates to an assay composition for detecting luminescence, which comprises an alkyl diethanolamine, for example, N-butyldiethanolamine (BDEA). In embodiments, the assay composition comprises 2-dibutylaminoethanol (BDAE). | 2022-01-20 |
20220018847 | REAGENTS FOR QUANTITATIVE MASS SPECTROMETRY - In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems. | 2022-01-20 |
20220018848 | METHODS OF SCREENING - The invention provides a method of identifying a peptide interaction site on a target protein wherein the target protein modulates the phenotype of a mammalian cell, using mammalian encoded peptides (SEPs) such as short open reading frame (sORF) encoded peptides. The invention further provides a method for the identification of new therapeutic targets and protein interaction sites for use in drug discovery. | 2022-01-20 |
20220018849 | SERINE HYDROLASE PROFILING ASSAY IN BIOTHERAPEUTICS - The present disclosure describes a method of identifying serine hydrolase in a biological test sample obtained from protein production with a fluorophosphonate-containing probe. The present disclosure also provides a method of identifying one or more serine hydrolases in the biological test sample as causing PS-80 or PS-20 degradation. | 2022-01-20 |
20220018850 | COMPOSITIONS AND METHODS FOR ASSAYING NEUTRALIZING ANTIBODIES - Provided herein are compositions and methods for analyzing neutralizing antibodies to SARS-CoV-2, for example, in a sample from a subject suspected of having, having, or having had (e.g., having recovered from) a SARS-CoV-2 infection, or a subject having received a prophylactic and/or therapeutic intervention for a coronavirus infection. | 2022-01-20 |
20220018851 | DETERMINATION OF PARKINSON'S DISEASE - Methods and compositions for accurate identification of Parkinson's disease are disclosed. More particularly, the disclosure is directed to the determination of Parkinson's disease in ante-mortem tissue samples. | 2022-01-20 |
20220018852 | METHODS AND KITS FOR DETECTING LIVER DYSFUNCTION IN A SUBJECT - Most chronic liver diseases are notoriously asymptomatic, until cirrhosis with clinical decompensation occurs. The use of early diagnosis strategies is vital to maintain patients in a symptom-free state and to delay decompensation, and thus improve the outcome. Albumin (HAS) undergoes several post-translational modifications in hepatocytes but clinical relevance of some of these modifications has been recently investigated in advanced liver diseases. Now, the inventors demonstrate that the binding capacities of some ligands, measured by inductively coupled plasma mass spectrometry (ICP-MS), are significantly different between cirrhotic patients and patients with no liver dysfunctions. The decreased binding capacities in cirrhotic patients were paralleled by the presence of significantly higher HSA isoforms Animal experimentations were also conducted to explore the precocity of HSA modifications in the course of chronic liver dysfunction. This allow the inventors to assume that the most important modifications of albumin structure due to liver dysfunction could be revealed by measuring the unbound fraction of specific ligands spiked in serum. | 2022-01-20 |
20220018853 | USE OF GILZ AS A BIOMARKER IN SEPSIS - Septic shock is the leading cause of death in intensive care units. Previous studies have highlighted the immunosuppressive protein GILZ (glucocorticoid-induced leucine zipper) as a regulator of innate and adaptive immune responses. To go deeper in the understanding of GILZ protective role during sepsis, the inventors studied in vivo the consequences of a targeted overexpression of GILZ in monocytes and macrophages (M/M) in animal models of sepsis. In addition, they monitored the expression of GILZ in M/M of both patients with septic shock and septic mice. In particular, the inventors show that the overexpression of GILZ limited to M/M leads to an increase survival rate in mice with CLP-induced sepsis. These results provided new evidence for a central role of GILZ in M/M on the pathophysiology of septic shock, and pinpoint the fact that GILZ would be suitable for predicting survival time of patient suffering from sepsis. Moreover these results indicate that determining the level of GILZ expression level in monocytes/macrophages of patients suffering from sepsis is suitable for identifying those patients that will respond or not to treatment with a corticoid. | 2022-01-20 |
20220018854 | METHODS OF DETECTING MARKERS FOR INFLAMMATORY CONDITIONS AND FOOD SENSITIVITY IN COMPANION ANIMALS - The present invention provides methods and systems to accurately detect and measure levels of endogenous antibodies, for examples endogenous IgA, to particular antigens in a biological sample from a companion animal, which is useful to diagnose inflammatory conditions, including bowel disease (IBD), gastrointestinal infections, and food sensitivities in companion animals, e.g., dogs or cats, and to distinguish among such gastrointestinal disorders. Such methods and systems identify whether a sample from the patient is associated with an inflammatory condition, infection, and/or food sensitivity condition, by using non-invasive means, thus conveniently providing information useful for guiding treatment decisions. | 2022-01-20 |
20220018855 | RGMa Fragment Based Diagnostic Assay - Provided are diagnostic assays and method s of using the diagnostic assays for detecting and quantifying RGMa fragments in a sample. The methods may be used detection of the RGMa fragments to monitoring drug treatment and effectiveness of drug treatment in neurodegenerative diseases. | 2022-01-20 |
20220018856 | ANTIBODY CONJUGATE - The present invention provides an improvement of sensitivity in immunological measurement of tau protein. Specifically, the present invention provides an antibody conjugate comprising two or more kinds of anti-tau protein antibodies bound to a carrier. | 2022-01-20 |
20220018857 | BLOOD-BASED ASSAY FOR DETECTING TAUOPATHY OR AMYLOIDOGENIC DISEASE - A method for detecting p217+tau in blood-based samples from a subject with high sensitivity, accuracy, and precision. The assay comprises contacting a sample with a capture antibody directed against a p217+tau epitope to bind the capture antibody to p217+tau peptides in plasma to form antibody-peptide complexes, and separately contacting the antibody-peptide complexes with a detection antibody to bind the detection antibody to the antibody-peptide complexes. The amount of p217+tau is determined by detecting the detection antibody. The amount of p217+tau detected is used to determine whether the subject has tauopathy or is at risk of developing tauopathy, or whether the subject has amyloidogenic disease or is at risk of developing amyloidogenic disease when the amount of p217+tau peptides is above a predetermined threshold value. The method has improved sensitivity such that the predetermined threshold value is above a Lower Limit of Quantification and/or Lower Limit of Detection of the assay. | 2022-01-20 |
20220018858 | THERAPEUTIC AND DIAGNOSTIC METHODS AND COMPOSITIONS FOR NEURODEGENERATIVE DISEASES - Methods and compositions relating to motor neurons derived from induced pluripotent stem cells of subjects having a neurodegenerative disease, where the motor neurons exhibit phenotypes characteristic of the neurodegenerative disease, are provided herein. In particular, the present invention provides methods for screening putative therapeutic agents and methods for diagnosing living subjects as having a neurodegenerative disease. In addition, the present invention provides therapeutic gene transfer methods for treating or preventing a neurodegenerative disease in a subject in need thereof. | 2022-01-20 |
20220018859 | TEST METHODS FOR DIAGNOSING CHRONIC WASTING DISEASE - A prion disease test kit is provided that allows for quick sample collection by an untrained individual and accurate testing of the sample in a lab, which is remote from the sample collection location. The prion disease test kit allows a lay person to easily collect tissue samples from the field and submit the collected tissue samples for prion disease testing, such as testing for chronic wasting disease, at a different location. | 2022-01-20 |
20220018860 | SAMPLE PREPARATION AND TEST METHODS FOR DIAGNOSING CHRONIC WASTING DISEASE - A prion disease test kit is provided that allows for quick sample collection by an untrained individual and accurate testing of the sample in a lab, which is remote from the sample collection location. The prion disease test kit allows a lay person to easily collect tissue samples from the field and submit the collected tissue samples for prion disease testing, such as testing for chronic wasting disease, at a different location. | 2022-01-20 |
20220018861 | AUTOMATIC ANALYSIS DEVICE - Provided are a device and a method capable of determining an optimal retrieving condition of a specimen rack according to various situations, when an error occurs in any specimen among a plurality of specimens mounted on the specimen rack. When the error occurs in a specimen accommodated in a specimen container mounted on the specimen rack, conveyance of the specimen rack is controlled on the basis of information about the specimen having the error and a specimen accommodated in another specimen container on the specimen rack on which the specimen container with the specimen accommodated therein is mounted, and the retrieval condition of the specimen rack. | 2022-01-20 |
20220018862 | MANAGEMENT SYSTEM AND MANAGEMENT METHOD - A management system including at least one processor, wherein the processor is configured to acquire an image obtained by imaging an outer surface of each of plural sample containers which contains a sample and in which name information of a subject from whom the sample is collected and subject discrimination information for discriminating plural subjects having the same surname and the same name are given to the outer surface, recognize the name information and the subject discrimination information given to each of the sample containers based on the image, and associate a test result related to the sample contained in each of the sample containers with a test order including the name information and the subject discrimination information, based on a result of the recognition and the test order. | 2022-01-20 |
20220018863 | MANAGEMENT SYSTEM AND MANAGEMENT METHOD - A management system including at least one processor, wherein the processor is configured to acquire a captured image obtained by imaging an outer surface of each of plural sample containers which contains a sample and in which discrimination information for discriminating a subject from whom the sample is collected is given to the outer surface, and associate a test result related to the sample contained in each of the sample containers with a test order in which information of a discrimination image including the discrimination information is registered in advance for each subject, based on the captured image and the test order. | 2022-01-20 |
20220018864 | MANAGEMENT SYSTEM AND MANAGEMENT METHOD - A management system including at least one processor, wherein the processor is configured to acquire an image obtained by imaging a sample container containing a sample, recognize relevant information related to reliability of a test result related to the sample based on the image, and derive reliability information indicating the reliability of the test result related to the sample based on the recognized relevant information. | 2022-01-20 |
20220018865 | MANAGEMENT SYSTEM, MANAGEMENT METHOD, AND DUMMY CONTAINER - A management system including a processor, the processor is configured to acquire an image obtained by imaging an outer surface of each of plural sample containers and a boundary container, the sample container containing a sample and in which subject information of a subject from whom the sample is collected is given to the outer surface, the boundary container in which group boundary information indicating a boundary between plural groups of subjects is given to the outer surface, recognize the subject information and the group boundary information based on the image, and associate a test result related to the sample contained in each of the sample containers with a test order which includes the subject information and in which the group is divided corresponding to the group boundary information, based on a result of the recognition and the test order. | 2022-01-20 |
20220018866 | MULTIPLE CAROUSEL CARTRIDGE-BASED DISPENSING SYSTEM AND METHOD - An improved system and method for the selection and dispensing of reagents onto a target testing medium in an automated laboratory environment. The system utilizes multiple carousels rotatably-mounted upon a central turntable. The position of the central turntable, as well as the rotation of each carousel is controlled by a microprocessor-based control system. Multiple dispensers, each capable of storing and dispensing a particular reagent, are mounted about the circumference of each carousel. This configuration provides much higher reagent density than previously available. The testing medium is positioned at one or more loading stations. The control system directs the central turntable to a position from which a selected one of the carousels can be rotated so as to position a selected dispenser above the testing medium. The selected dispenser is then actuated to release a predetermined reagent onto the testing medium. The system can be configured so that multiple reagents can be dispensed, each from an associated dispenser, onto a single or multiple testing mediums. Each of these actuated dispensers being positioned over the targeted testing medium(s) positioned at one or more loading stations. | 2022-01-20 |
20220018867 | AUTOMATIC ANALYSIS DEVICE AND AUTOMATIC ANALYSIS METHOD - In an automatic analysis device, it is possible during specimen analysis to add/deposit one rack at a time without stopping the analysis, and it is easy to ascertain the analysis sequence. The analyzer has an analysis module, a rack transport module for transporting a specimen rack in which a specimen container storing a specimen is loaded, and a control device. The rack transport module includes a rack supply part for supplying a specimen rack, a rack accommodating part for accommodating a specimen rack, a rack transport line for transporting a specimen rack supplied from the rack supply part, a dispensing line for transporting a specimen rack to the analysis module, and a rack rotor for transferring a specimen rack between the rack transport line and the dispensing line. Operation of the rack supply part for supplying a specimen rack can be stopped independently of the operation of the analysis module. | 2022-01-20 |
20220018868 | LABORATORY SAMPLE DISTRIBUTION SYSTEM AND METHOD FOR OPERATING THE SAME - A laboratory sample distribution system comprising a plurality of sample container carriers, each adapted to carry one or more sample containers, each carrier comprising at least one magnetically active device and at least one electrically conductive member, a transport plane adapted to support the carriers, a plurality of electro-magnetic actuators stationary arranged below the transport plane, the actuators being adapted to move the carriers on top of the transport plane by applying a magnetic force to the carriers, a plurality of inductive sensors distributed over the transport plane, a control unit configured to control the movement of the carriers using an output signal provided by the inductive sensors by driving the actuators such that the carriers move along corresponding transport paths, and an evaluation unit configured to linearize the output signal from an inductive sensor by means of a linearization algorithm. | 2022-01-20 |
20220018869 | AUTOMATIC ANALYZER - The object of the invention is to avoid a decrease in dispensing accuracy of a sample, a reagent, or the like as a temperature changes. In an automatic analyzer, a dispensing nozzle sucks the sample from a sample container holding the sample and discharges the sample to a reaction container. A syringe pump controls an amount of change in a volume of water. A first pipe connects the dispensing nozzle and the syringe pump. An electromagnetic valve flows or stops the water. A second pipe connects the electromagnetic valve and the syringe pump. A branch pipe branches the water. A third pipe connects the electromagnetic valve and the branch pipe. A case accommodates at least the syringe pump, the first pipe, the electromagnetic valve, the second pipe, the branch pipe, and the third pipe. Further, the third pipe includes a heat exchange unit that performs heat exchange of the water. | 2022-01-20 |
20220018870 | COIL BODY, INDUCTIVE ROTATIONAL SPEED SENSOR, AND METHOD FOR PRODUCING THE SAME - A coil body for an inductive rotational speed sensor, including: a base body having at least one winding region for coil windings about an axial axis and an opening for receiving a pole assembly along the axial axis; and two current rails, each of which run parallel to the axial axis and include a contact region for electrical connection cables to connect the coil in the winding region to the electrical connection cables, in which each of the contact regions includes at least one bendable section to guide the electrical connection cables at least in some sections parallel to the axial axis or, perpendicular thereto, in a radial manner. Also described are a related inductive rotational speed sensor, and related methods. | 2022-01-20 |
20220018871 | DETECTION OF POLYETHYLENE AND SILICON OR OTHER MATERIAL COMBINATIONS USED IN MOTION SENSORS OR OTHER DEVICES - A method includes transmitting first optical energy towards a space being scanned. The method also includes detecting one or more instances of a first material in the space using first return optical energy, where the first return optical energy is based on the transmitted first optical energy. The method further includes, for each of the one or more instances of the first material, transmitting second optical energy towards a portion of the space in which the instance of the first material was detected. The method also includes detecting one or more instances of a second material in the space using second return optical energy, where the second return optical energy is based on the transmitted second optical energy. In addition, the method includes identifying a presence of at least one type of device in the space based on instances of the first and second materials detected in the space. | 2022-01-20 |
20220018872 | ACCELEROMETER INCLUDING RECTANGULAR COIL AND RECTANGULAR POLE PIECE - This disclosure is related to devices, systems, and techniques for determining an acceleration. For example, an accelerometer system includes a proof mass, a pole piece connected to the proof mass, and a coil disposed around the pole piece and connected to the proof mass, where the coil is rectangular in shape. Additionally, the accelerometer system includes circuitry configured to deliver an electrical signal to the coil in order to maintain the proof mass at a null position and determine an electrical current value corresponding to the electrical signal. Additionally, the circuit is configured to identify, based on the electrical current value, an acceleration of the accelerometer system. | 2022-01-20 |
20220018873 | SCANNING PROBE MICROSCOPE AND SCANNING PROBE MICROSCOPE OPTICAL AXIS ADJUSTMENT METHOD - A scanning probe microscope is provided with a cantilever having a probe at a tip end thereof, an optical system for emitting laser light onto the cantilever and detecting the laser light reflected by the cantilever, an imaging unit for imaging a range including a position of the tip end of the cantilever when adjusting an optical axis of the laser light, an image processing unit for detecting a position of the tip end of the probe and a position of a spot of the laser light from an image generated by the imaging unit, an optical axis adjustment unit for adjusting the optical axis of the laser light based on the detected positions, and a sample holder for holding a sample. The sample holder includes a mirror. | 2022-01-20 |
20220018874 | METHOD AND APPARATUS FOR TESTING PRINTED CIRCUIT BOARDS - A method for testing printed circuit boards ( | 2022-01-20 |
20220018875 | CONTACT PIN AND SOCKET - A contact pin includes: a first contact portion provided on one end side in a first direction; a second contact portion provided on another end side in the first direction; and an elastically deformable spring portion provided on a middle portion between the first contact portion and the second contact portion, wherein the first contact portion, the second contact portion, and the middle portion are integrally formed, and the first contact portion includes a plurality of cut sections each being displaceable in the first direction. | 2022-01-20 |
20220018876 | PROBE CARD DEVICE AND FENCE-LIKE PROBE THEREOF - A probe card device and a fence-like probe thereof are provided. The fence-like probe includes a stroke segment, a fan-out segment, and a testing segment. The stroke segment is in an elongated shape defining a longitudinal direction, and the stroke segment has two end portions and a plurality of penetrating slots that are arranged along a fan-out direction perpendicular to the longitudinal direction, so that the stroke segment is deformable to store an elastic force by being applied with a force. The fan-out segment and the testing segment are respectively connected to the two end portions of the stroke segment. The fan-out segment has a fixing point arranged away from the stroke segment, and the testing segment has an abutting point arranged away from the stroke segment. Along the fan-out direction, the fixing point is spaced apart from the abutting point by a fan-out distance. | 2022-01-20 |
20220018877 | PROBE UNIT - A probe unit includes: a first contact probe configured to come in contact with a signal electrode; a second contact probe configured to come in contact with a ground electrode; a probe holder including a first holder hole through which the first contact probe passes, and a second holder hole through which the second contact probe passes; and a conductive floating member including a first through hole to which the first contact probe is inserted and the signal electrode is inserted, and a second through hole to which the second contact probe is inserted and the ground electrode is inserted. The probe holder is configured such that at least an inner circumferential surface of the first holder hole has an insulating property, and the probe unit has a coaxial structure in which central axes of the first contact probe and the first through hole are aligned with each other. | 2022-01-20 |
20220018878 | Mutual Inductance-Type Current Sensing - Mutual inductance-type current sensing apparatus ( | 2022-01-20 |
20220018879 | INTEGRATED CURRENT SENSOR WITH MAGNETIC FLUX CONCENTRATORS - A packaged current sensor includes a lead frame, an integrated circuit, an isolation spacer, a first magnetic concentrator, and a second magnetic concentrator. The lead frame includes a conductor. The isolation spacer is between the lead frame and the integrated circuit. The first magnetic concentrator is aligned with the conductor. The second magnetic concentrator is aligned with the conductor. | 2022-01-20 |
20220018880 | CURRENT SENSOR AND METHOD - A current sensor arrangement for measuring an AC electrical current, comprising: an electrical conductor having three transverse rectangular cut-outs; a sensor device comprising two sensor elements spaced apart along a first direction for measuring two magnetic field components oriented in said first direction, and configured for determining a magnetic field difference or magnetic field gradient, and for determining the AC current based on said difference or gradient. The sensor device is positioned at a particular location relative to the second cut-out, such that the magnetic field difference or gradient is substantially proportional to the AC current for frequencies from 100 Hz to 2 kHz. A current sensor system. A method of measuring an AC current with improved accuracy. | 2022-01-20 |
20220018881 | SQUELCH AND DISCONNECT DETECTOR - A circuit is disclosed. The circuit includes an input port, an output port, a squelch detector and a disconnect detector. The squelch detector and the disconnect detector are enabled or disabled by a signal such that only one of the squelch detector and the disconnect detector is active at a given time. When the squelch detector is active, a threshold generator generates a squelch threshold for the squelch detector based on a squelch configuration data indicative of a predefined squelch threshold. When the disconnect detector is active, the threshold generator generates a disconnect threshold for the disconnect detector based on a disconnect configuration data indicative of a predefined disconnect threshold. | 2022-01-20 |
20220018882 | POWER DETECTOR - In certain aspects, a method is provided for measuring power using a resistive element coupled between a power amplifier and an antenna. The method includes squaring a voltage from a first terminal of the resistive element to obtain a first signal, squaring a voltage from a second terminal of the resistive element to obtain a second signal, and generating a measurement signal based on a difference between the first signal and the second signal. In some implementations, the resistive element is implemented with a power switch. | 2022-01-20 |
20220018883 | METHOD AND APPARATUS FOR PULSED POWER MEASUREMENT - A measurement method and apparatus for determining power levels of pulsed power signals, wherein the pulsed power signals are needed for some applications with a high dynamic range and a high speed simultaneously. The apparatus and the measurement method particularly used to evaluate a performance of fiber optic sensors, optical pulse generators, switching devices and debugging other pulsed power systems. | 2022-01-20 |
20220018884 | ELECTRONIC DEVICE FOR MEASURING BEAMFORMING SIGNAL HAVING PLURALITY OF DIRECTIONS, AND METHOD OF OPERATING SAME - An electronic device, according to one embodiment disclosed in the present disclosure, may be configured to: form a beam in any one direction of a first direction and directions rotated by a first angle on the basis of the first direction; control a device under test (DUT) so as to emit a designated signal by using the formed beam; and check antenna performance of the DUT at least on the basis of intensity measured from a signal measuring device. In addition, various embodiments inferred from the specification are also possible. | 2022-01-20 |
20220018885 | ELECTRICAL CONTROL DEVICE DETECTION CIRCUIT, DETECTION METHOD, AND ELECTRIC VEHICLE - Embodiments of this application relate to the technical field of electronics, and disclose an electrical control device detection circuit, a detection method, and an electric vehicle. In some embodiments of this application, the detection circuit is configured to detect a drive circuit of the electrical control device. The drive circuit includes a high-side switch unit. The detection circuit includes a first detection module and a control module. A first end of the first detection module is connected to a first end of the electrical control device. A second end of the first detection module is connected to a second end of the electrical control device. A third end of the first detection module is connected to the control module. | 2022-01-20 |
20220018886 | METHOD AND APPARATUS FOR IDENTIFYING A GRID FAULT - A method and apparatus for identifying a fault in an alternating current electrical grid is provided. | 2022-01-20 |