04th week of 2014 patent applcation highlights part 36 |
Patent application number | Title | Published |
20140023649 | ANTIBODIES THAT BIND IL-4 AND/OR IL-13 AND THEIR USES - The present invention relates to novel humanized anti-IL-4 and IL-13 antibodies and fragments thereof and novel bispecific antibodies and fragments thereof that specifically bind to IL-4 and IL-13. The invention also includes uses of the antibodies to treat or prevent IL-4 and/or IL-13 mediated diseases or disorders, including allergic asthma and dermatitis. | 2014-01-23 |
20140023650 | Methods of Treating and/or Preventing Cell Proliferation Disorders with IL-17 Antagonists - The invention relates generally to methods of treating and/or preventing proliferative diseases, such as cancers, using antagonists of IL-17. The invention also relates to methods and kits for identifying subjects who are likely to respond to treatment and/or prevention of proliferative diseases with antagonists of IL-17. | 2014-01-23 |
20140023651 | STEM CELL FACTOR INHIBITOR - Provided herein are methods, compositions, and uses relating to inhibitors of stem cell factor. For example, provided herein are antibodies targeting stem cell factor and methods for treating fibrotic and tissue remodeling diseases. | 2014-01-23 |
20140023652 | METHODS AND COMPOSITIONS BASED ON SHIGA TOXIN TYPE 1 PROTEIN - The invention is based on the discovery of the epitope in the Stx1 protein for the 13C4 antibody. The invention features non-full length Stx1 polypeptides that include the epitope for the 13C4 monoclonal antibody epitope. The invention also features methods of producing anti-Stx1 antibodies specific for the 13C4 epitope of the Stx1 protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with | 2014-01-23 |
20140023653 | BOLDINE DERIVATIVES FOR PROMOTING BONE GROWTH - The present invention provides compositions comprising a compound of Formula I, and salts, hydrates, and isomers thereof. Methods of promoting bone formation and/or bone growth, treating renal disease, and treating cancer in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I, are also provided. Medical devices comprising a compound of Formula I are also provided. | 2014-01-23 |
20140023654 | COMBINATION OF ANGIOPOIETIN-2 ANTAGONIST AND OF VEGF-A, KDR AND/OR FLT1 ANTAGONIST FOR TREATING CANCER - The invention relates to agents which possess anti-angiogenic activity and are accordingly useful in methods of treatment of disease states associated with angiogenesis in the animal or human body. More specifically the invention concerns a combination of an antagonist of the biological activity of Angiopoietin-2 and an antagonist of the biological activity of VEGF-A, and/or KDR, and/or Flt1, and uses of such antagonists. | 2014-01-23 |
20140023655 | FORMULATIONS WITH REDUCED VISCOSITY - The present invention is directed to a method for reducing the viscosity of a formulation containing citrate and a therapeutic protein and formulations made using the claimed method. | 2014-01-23 |
20140023656 | PHARMACEUTICAL COMPOSITION FOR TREATMENT AND PREVENTION OF TH3 MARCH-RELATED DISEASES - The present invention provides a medicinal agent and a method for each of various testing or the like, which enable the treatment and prevention, particularly preventive treatment, of Th3 march-related diseases. The present invention also provides a pharmaceutical composition for treating and/or preventing Th3 march-related diseases, which comprises zinc, calcium and phosphorus and additionally comprises pumpkin seeds and corn silk, and which preferably can activate the DNA repairing ability of a zinc finger, particularly the ability of repairing defect or mutation of DNA for a filaggrin gene, of a zinc finger. | 2014-01-23 |
20140023657 | IN VITRO METHOD FOR IDENTIFYING COMPOUNDS FOR CANCER THERAPY - The present invention relates to an in vitro method for identifying and evaluating compounds useful in the treatment of different types of cancer, especially lung, breast, colorectal and bladder cancer in an individual, for determining the stage or severity of said cancer in the individual, or for monitoring the effect of the therapy administered to an individual having said cancer; to finding, identifying, developing and evaluating the efficacy of compounds for the therapy of said cancer, for the purpose of developing new medicinal products; as well as to agents inhibiting the expression and/or activity of the choline kinase alpha protein and/or the effects of this expression. | 2014-01-23 |
20140023658 | REGULATING IL-4 AND IL-3 LEVELS BY BLOCKING HIGH AFFINITY BINDING BY IL-3, IL-5 AND GM-CSF TO THEIR COMMON RECEPTOR - A method of reducing IL-4 and/or IL-13 levels in the lung of a mammal with elevated levels thereof, includes the step of administering to the mammal an effective amount of a βc receptor blocker capable of blocking the binding of all three of IL-3, IL-5 and GM-CSF to the βc common chain to thereby reduce the IL-4 and/or IL-13 levels. | 2014-01-23 |
20140023659 | COMPOSITION AND METHOD FOR THE DIAGNOSIS AND TREATMENT OF DISEASES ASSOCIATED WITH NEURITE DEGENERATION - Provided herein are antibodies and methods of using the antibodies to treat and diagnose neurite degenerative diseases and disorders. | 2014-01-23 |
20140023660 | Anti-IL 13 Human Antibodies - The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma. | 2014-01-23 |
20140023661 | COMBINATION THERAPY - The present invention relates to a pharmaceutical combination comprising an alpha-isoform specific phosphatidylinositol 3-kinase inhibitor compound, such as (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide), or pharmaceutically acceptable salt thereof, and an IGF1R inhibitor (e.g., the IGF1R inhibitor ANTIBODY A, or a variant or derivative thereof), a pharmaceutical composition comprising such combination, methods for treating cancer comprising administration of therapeutically effective amounts of such inhibitors to a subject in need thereof, and uses of such combination for the treatment of cancer. | 2014-01-23 |
20140023662 | NON-ANTAGONISTIC EGFR-BINDING MOLECULES AND IMMUNOCONJUGATES THEREOF - Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to EGFR are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided. | 2014-01-23 |
20140023663 | 1,2,5-Oxadiazoles As Inhibitors Of Indoleamine 2,3-Dioxygenase - The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives. | 2014-01-23 |
20140023664 | Activatable Antibodies Having Non-Binding Steric Moieties and Methods of Using the Same - The invention relates generally to activatable antibodies and methods of making and using these activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications. | 2014-01-23 |
20140023665 | NOVEL MAYTANSINOID DERIVATIVES WITH SULFOXIDE LINKER - The invention relates to novel maytansinoid compounds having sulfoxide linkers and more specifically to novel maytansinoid compounds of structural formula (I) and (II). The invention also provides conjugates of the maytansinoid compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. | 2014-01-23 |
20140023666 | AURISTATIN TYRAMINE PHOSPHATE SALTS AND AURISTATIN AMINOQUINOLINE DERIVATIVES AND PRODRUGS THEREOF - The present invention relates to new auristatin compounds and prodrugs thereof, compositions comprising them and uses thereof. | 2014-01-23 |
20140023667 | PYRROLIDINE-FUSED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoisomers, wherein each of W, Z, R | 2014-01-23 |
20140023668 | C5-C6 OXACYCLIC-FUSED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE - In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula: (I) and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoisomers, wherein each of ring A, ring B, ring C, R | 2014-01-23 |
20140023669 | USE OF A HYPOALLERGENIC CEREAL COMPOSITION FOR INDUCING SPECIFIC ORAL TOLERANCE - A partial hydrolysate of cereal protein for use in inducing specific oral tolerance in a young mammal with allergy to said cereal protein, wherein the hydrolysate has a degree of hydrolysis between 9 and 18%, is disclosed. | 2014-01-23 |
20140023670 | CANCER VACCINE COMPOSITION - A cancer vaccine composition for human leukocyte antigen (HLA)-A*0206-positive persons, comprising a protein product of the tumor suppressor gene WT1 or a partial peptide thereof. | 2014-01-23 |
20140023671 | TOMM34 PEPTIDES AND VACCINES INCLUDING THE SAME - The present invention provides isolated peptides or the fragments derived from SEQ ID NO: 42, which bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL). The peptides may include one of the above mentioned amino acid sequences with substitution, deletion, or addition of one, two, or several amino acids sequences. The present invention also provides pharmaceutical compositions including these peptides. The peptides of this invention can be used for treating cancer. | 2014-01-23 |
20140023672 | FOXM1 PEPTIDE AND MEDICINAL AGENT COMPRISING THE SAME - An objective of the present invention is to provide a means for enabling cancer immunotherapy that targets approximately 30% of various cancer patients that highly express forkhead box M1 (FOXM1) among the Japanese, by identifying FOXM1-derived peptides that can activate cancer cell-damaging human killer T cells by binding to HLA-A2. The present invention provides a peptide of (A) or (B) below: | 2014-01-23 |
20140023673 | NUCLEIC ACID MOLECULES ENCODING NOVEL HERPES ANTIGENS, VACCINE COMPRISING THE SAME, AND METHODS OF USE THEREOF - Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of herpes virus antigens, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against herpes virus using the vaccines that are provided. | 2014-01-23 |
20140023674 | METHODS AND COMPOSITIONS EMPLOYING IMMUNOGENIC FUSION PROTEINS - Compositions and methods are provided for the prevention and treatment of bacterial infections, including pneumococal infections. Compositions provided herein comprise a variety of immunogenic fusion proteins, wherein at least one polypeptide component of a given fusion protein comprises a CbpA polypeptide and/or a cytolysoid polypeptide, or an active variant or fragment thereof. Methods are provided for the prevention and treatment of bacterial infections, including pneumococcal infections by employing the various immunogenic fusion proteins having at least one polypeptide component comprising a CbpA polypeptide and/or a cytolysoid polypeptide, or an active variant or fragment thereof. | 2014-01-23 |
20140023675 | SULPHATED ARABINOGALACTANS, APIOGALACTURONANS AND SULPHATED HETEROGLYCANS FOR TREATING DISEASES CAUSED BY THE INFLUENZA VIRUS - The present invention relates to polysaccharides selected from sulphated arabinogalactans, apiogalacturonans and sulphated heteroglycans intended to be used as a drug for the preventive or curative treatment of an influenza virus, as well as to the pharmaceutical compositions including, in particular in combination with at least one pharmaceutically acceptable carrier:
| 2014-01-23 |
20140023676 | COSMETIC COMPOSITION CONTAINING SPIRULINA, AND COSMETIC TREATMENT METHOD - The present invention relates to a cosmetic composition for topical application containing | 2014-01-23 |
20140023677 | HERBAL COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASES AND IMPROVING MEMORY IMPAIRMENT - The present invention relates to a composition for preventing or treating neurological diseases including an extract of | 2014-01-23 |
20140023678 | Method of Providing Protective Immunity against Heterologous Leptospira Strains - The present invention provides compositions and methods for eliciting protective immunity in animals against | 2014-01-23 |
20140023679 | LIVE ATTENUATED VIRUS VACCINES FOR LA CROSSE VIRUS AND OTHER BUNYAVIRIDAE - The invention relates to vaccine compositions including CEV serogroup immunogens, attenuated and inactivated viruses of the CEV serogroup and chimeric Bunyaviridae. Also disclosed are methods of treating or preventing CEV serogroup infection in a mammalian host, methods of producing a subunit vaccine composition or an immunogenic composition, isolated polynucleotides comprising a nucleotide sequence encoding a CEV serogroup immunogen, methods for detecting La Crosse virus (LACV) infection in a biological sample and infectious chimeric Bunyaviridae. | 2014-01-23 |
20140023680 | INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS - Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided. | 2014-01-23 |
20140023681 | Attenuated Swine Influenza Vaccines and Methods of Making and Use Thereof - This disclosure provides attenuated swine influenza strains, particularly those produced via a reverse genetics approach, compositions comprising same, and methods of production and use thereof. The attenuated strains are engineered to encode HA proteins having additional glycosylation sites, relative to the HA proteins encoded by the corresponding virulent parental viruses. Advantageously, the attenuated influenza strains may be administered | 2014-01-23 |
20140023682 | Cancer Inhibiting Agent, Antibody Production Enhancing Agent, And Therapeutic Agent For Hepatitis - Provided are an agent for inhibition of cancer development, an agent for improvement of antibody productivity, and an agent for treatment of hepatitis. The agents have been completed by finding that cancer development is inhibited in a healthy subject by administering NK cells, and antibody productivity is improved by administering NK cells and a vaccine to a patient. | 2014-01-23 |
20140023683 | IDENTIFICATION OF TRANSMITTED HEPATITIS C VIRUS (HCV) GENOMES BY SINGLE GENOME AMPLIFICATION - This invention provides methods for identifying HCV genomes and more specifically, methods for identifying nucleotide sequence of viral structural proteins at the time of HCV viral transmission. The method of the invention utilizes single genome amplification and sequencing of circulating virus as well as phylogenetic analysis of the resulting nucleotide sequence for identifying transmitted HCV genomes. Also provided are HCV genomes and corresponding nucleotide sequence for transmitted and circulating HCV virus. The invention further provides methods of administering a vaccine comprising one or more identified transmitted HCV sequences. | 2014-01-23 |
20140023684 | Vaccine Against Pasteurellaceae - The invention relates to vaccines providing protection against infections caused by members of the Pasteurellaceae family comprising outer membrane vesicles as the only active components, wherein the outer membrane vesicles are obtained from one or more strains of the Pasteurellaceae family, with the proviso that hypervesiculating strains are excluded. The invention also relates to a method for preparing such a vaccine. | 2014-01-23 |
20140023685 | BIVALENT VACCINE FOR MARINE FISH AND METHOD FOR MAKING THE SAME - A bivalent vaccine against | 2014-01-23 |
20140023686 | SOLUBLE ICAM-1 AS BIOMARKER FOR PREDICTION OF THERAPEUTIC RESPONSE - The present invention relates to the field of immunology and, in particular, to a vaccination procedure for treatment of a patient against diseases caused for example by infection or cancers. More particularly, the invention relates to methods for predicting whether a subject is or is not susceptible to developing a prophylactic or therapeutic response, preferably immune response, after such vaccination. The present invention relates to methods and compositions for selecting patients best able to raise a therapeutic immune response in vivo by an immunogenic composition, in particular a vaccine. | 2014-01-23 |
20140023687 | CLONED BIOLOGICAL MATERIAL MEDICAL DEVICE AND METHOD THEREOF - A medical device, said medical device, comprises: a first component having a non-biological material; a second component having a cloned biological material, said second component being attached to said first component, wherein said first component and said second component are operatively associated in a non-living medical device for at least one of treatment, diagnosis, cure, mitigation and prevention of disease, injury, handicap or condition in a living organism. In another aspect, a method comprises: preparing a cloned biological material from a tissue or an organ; attaching said biological material to a medical device; interfacing said biological material with the non-biological material; providing treatment, diagnosis, cure, mitigation and prevention of disease, injury, handicap or condition in a living organism. | 2014-01-23 |
20140023688 | ENCAPSULATED OILS - Provided herein is a silk material compositions and methods for encapsulating and/or stabilizing oil, lipid, hydrophobic or lipophilic compounds including active agents in a silk matrix. | 2014-01-23 |
20140023689 | COSMETIC INCLUDING URETHANE FOAM IMPREGNATED WITH COSMETIC COMPOSITION - Disclosed is a cosmetic including polyether-based urethane foam impregnated with a cosmetic composition. The cosmetic provides improved feeling in use, portability and stability. | 2014-01-23 |
20140023690 | POLYMER SURFACES CONTAINING HEAT LABILE COMPONENTS ADSORBED ON POLYMERIC CARRIERS AND METHODS FOR THEIR PREPARATION - Surfaces and members having one or more surfaces derived from compositions containing polymers and one or more heat labile and/or incompatible components adsorbed on carrier materials are provided. The heat labile components include materials that, unless adsorbed on a carrier, are transformed at the polymer's processing temperatures (such as for example, heat labile biocides). Incompatible components are materials that generally react or form gels, slimes or precipitates upon mixing. The carrier materials typically include inorganic and/or organic porous materials capable of remaining solid during processing temperatures. Methods for preparing the polymer surfaces and members having polymer surfaces are provided. Members include, but are not limited to, structures, articles, containers, devices, woven/nonwoven articles, remediation materials, and the like. | 2014-01-23 |
20140023691 | INHIBITION OF BACTERIAL BIOFILMS AND MICROBIAL GROWTH WITH IMIDAZOLE DERIVATIVES - Disclosure is provided for imidazole derivative compounds useful to inhibit the formation of biofilms and/or inhibit microbial growth, compositions including these compounds, devices including these compounds, and methods of using the same. | 2014-01-23 |
20140023692 | DRUG DELIVERY DEVICE - The invention provides an inflammation-responsive implantable device for the in situ delivery of one or more pharmaceutically active agents to a human or animal. The device comprises two differential release bioresponsive polymeric matrices (BPMs): an outer polymetric matrix and an inner polymeric matrix, both of which contain at least one pharmaceutically active agent or drug, typically an antibiotic and an anti-inflammatory agent, respectively. The therapeutically effective agent may be embedded in nanoparticles or nanobubbles. In response to inflammation, the pharmaceutically active agents are released, but at different rates: the rate of drug release from the inner polymeric matrix is lower than the rate of drug release from the outer polymeric matrix. Suitable polymers for forming the outer and inner polymeric matrices are hyaluronic acid and chitosan, respectively. A method of making the device and a method of treatment are also described. | 2014-01-23 |
20140023693 | PROTECTION OF MICROBIAL CELLS FROM ACIDIC DEGRADATION - A simple cellulose sulphate based microencapsulation technology has been applied to encapsulate bacterial or other microbial cells, which produce and release digestive enzymes and thereby provides an acid resistant shelter for these microbial cells. Surprisingly, the resulting spheres were found to provide sufficient protection for encapsulated cells from treatment with aqueous acidic solutions. Thereby the cellulose sulphate microencapsulated cells, such as probiotics are now enabled to survive passage, for example, through the stomach after consumption by a human or animal with a higher survival rate than those not within a microcapsule. After passing the stomach these cells are delivering products produced by them, e.g. enzymes or other nutrition factors. This technology therefore proves to be very useful in providing digestive or otherwise beneficial enzymes and/or of living microbial cells, into the lower gastrointestinal tract, where they could confer their health benefit to the host. | 2014-01-23 |
20140023694 | Systems and Methods for Concealing Medication and Making Treats - Medication can be concealed using a device that comprises a food storage container, a nozzle, and a base. The food storage container typically stores a non-solid food product that can be used to conceal medication, dispense toppings, and make treats. Furthermore, the food storage container can be configured to mate with a nozzle, which could control the flow of the food product within the food storage container. The base comprises a cavity configured to receive an open capsule, wherein the non-solid food product can be dispensed via the nozzle of the food storage container. | 2014-01-23 |
20140023695 | PATCH PREPARATION - A patch preparation containing a support and an adhesive layer formed on one surface of the support, wherein the adhesive layer contains 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine or a physiologically acceptable acid addition salt thereof, an acrylic polymer, lactic acid, sesame oil and one or more kinds of stabilizers selected from 2-mercaptobenzimidazole, 2,6-di-tert-butyl-4-methylphenol and propyl gallate. | 2014-01-23 |
20140023696 | TREATMENT FOR IDIOPATHIC PULMONARY FIBROSIS - The invention proposes a method of treatment of idiopathic pulmonary fibrosis by a liposomally formulated reduced glutathione. | 2014-01-23 |
20140023697 | METHODS AND SYSTEMS FOR NANOMEMBRANE CRYSTALLIZATION - In one aspect, embodiments of the invention provide a method, the method comprising contacting at least one osmotic body and a droplet comprising solvent and at least one solute. The contacting forms at least one thin film between the droplet and the at least one osmotic body. The method further comprises allowing solvent to transfer between the droplet and the at least one osmotic body, to form a precipitate of the at least one solute. | 2014-01-23 |
20140023698 | DOSAGE AND ADMINISTRATION FOR PREVENTING CARDIOTOXICITY IN TREATMENT WITH ERBB2-TARGETED IMMUNOLIPOSOMES COMPRISING ANTHRACYCLIN CHEMOTHERAPEUTIC AGENTS - Methods for determining dosage of HER2-targeted anthracycline-containing immunoliposomes are disclosed, as are methods of treating cancer patients with HER2-positive tumors using dosages so determined. Upon administration, the dosages share the low cardiotoxicity profile of standard dosages of non-immunoliposomal (untargeted), anthracycline-containing liposomes. | 2014-01-23 |
20140023699 | Biologically Active Taxane Analogs and Methods of Treatment by Oral Administration - The present invention relates to a novel chemical compound for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents. | 2014-01-23 |
20140023700 | CYCLIC PEPTIDE AND CONJUGATE THEREOF FOR BINDING TO KERATINOCYTES - A cyclic peptide capable of binding specifically to the α2 I domain of a collagen binding integrin receptor may be conjugated to a drug containing particle via a linker moiety. The conjugate may be used to target a therapeutic drug to a cell expressing a collagen binding integrin receptor on its surface. | 2014-01-23 |
20140023701 | Method and Composition for Ameliorating the Effects tor a Subject Exposed to Radiation or Other Sources of Oxidative Stress - Radiation-oxidative exposure treatment compositions comprise a mixture of micronutrient multivitamin and trace elements, a mixture of antioxidants and chemopreventative agents, and optionally a mixture of fatty acids. Micronutrient multivitamin and trace elements mixtures include vitamins A, Bp, B1, B2, B3, B5, B6, B7, B9, B12, C, D, E and K; inositol; calcium, iodine, magnesium, zinc, selenium, copper, manganese, chromium, molybdenum, potassium, boron and vanadium. Mixtures of non-essential antioxidants and chemopreventative agents include bioflavins, alpha lipoic acid, N-acetyl-L-cysteine (optionally) lutein, lycopene, astaxanthin, plant sterols, isoflavones, garlic extract, which provides allicin; green tea extract, cruciferous vegetable extract, fruit extracts, coenzyme Q-10, and resveratrol. Fatty acid mixtures include eicosapentaenoic acid and docosahexaenoic acid. | 2014-01-23 |
20140023702 | METHOD OF TREATING RETINITIS PIGMENTOSA - Provided is a method for improving day photopic vision and/or cone-derived visual field and visual function in a subject suffering from a retinal disease or trauma including administering to the subject a pharmaceutically effective amount of crude | 2014-01-23 |
20140023703 | NANOCAPSULES WITH A POLYMER SHELL - The invention relates to a system for administering active ingredients, including nanocapsules comprising an oil, a cationic surfactant and a polymer selected from the group consisting of polyglutamic acid (PGA), polyglutamic-polyethyleneglycol acid (PGA-PEG), hyaluronic acid (HA) and polyasparagine (PAsn) or a combination of same and, optionally, an active ingredient, with the condition that when the polymer includes polyglutamic acid or polyglutamic-polyethyleneglycol acid (PGA-PEG) the active ingredient is not a didemnin or a tamandarin. The invention also relates to methods for obtaining said nanocapsule system, the pharmaceutical compositions thereof and the use of same in medicine. | 2014-01-23 |
20140023705 | DOSAGE FORMS FOR ORAL ADMINISTRATION AND METHODS OF TREATMENT USING THE SAME - The invention relates to dosage forms that provide prolonged therapy. In particular, the invention relates to dosage forms including various pluralities of drug-containing resin particles. The invention also relates to methods of making these dosage forms and methods of treating using these dosage forms. | 2014-01-23 |
20140023706 | PHARMACEUTICAL COMPOSITIONS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL) CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID AND ADMINISTRATION THEREOF - A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid), and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a binder, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering an oral pharmaceutical formulation of Compound 1 to the patient. | 2014-01-23 |
20140023707 | Co-Processed Carbohydrate System as a Quick-Dissolve Matrix for Solid Dosage Forms - The present invention comprises a co-processed carbohydrate system, and formulations produced therefrom, which formulations are directly compressible into solid dosage forms, some of which rapidly and completely dissolve or disintegrate in the oral cavity within 60 seconds. The invention also comprises the solid dosage forms produced by directly compressing the co-processed carbohydrate system, some of which, when placed in the oral cavity, shall dissolve or disintegrate, preferably within about 60 seconds. | 2014-01-23 |
20140023708 | LAMINATED TABLET AND MANUFACTURING METHOD THEREFOR - According to the present invention, a multilayer tablet showing suppressed layer separation and a production method thereof are provided. A concave portion having a depth of not less than 0.1 mm Ka is formed on at least one surface Sa of the both front and back surfaces (Sa, Sb) of a multilayer tablet. Particularly, a multilayer structure obtained by, in tableting, forming a convex portion for forming the concave portion on at least the upper punch, and preliminarily compressing all layers in the multilayer tablet with the upper punch to form a concave portion having the same shape with a depth of not less than 0.1 mm on the upper surface of all layers, wherein the powder materials of the next layer are protruding into the concave portion, is a preferable embodiment. | 2014-01-23 |
20140023709 | ORAL TABLET COMPOSITIONS OF DEXLANSOPRAZOLE - Oral tablet compositions of dexlansoprazole or pharmaceutically acceptable salts or hydrated forms thereof having a gradual release and processes for the manufacture of the tablet composition and its use in the treatment of gastrointestinal disorders. | 2014-01-23 |
20140023710 | MILNACIPRAN FORMULATIONS - The present invention provides formulations comprising milnacipran or pharmaceutically acceptable salts thereof (e.g., milnacipran hydrochloride), including immediate release formulations and modified formulations, such as delayed release and extended release formulations. The present invention provides formulations with improved stability and high bioavailability. Processes for preparing the formulations as well as methods of treating conditions by administering the formulations are also described. | 2014-01-23 |
20140023711 | BIOACTIVE SURFACE CAPABLE OF GENETICALLY MODIFYING BIOLOGICAL CELLS OR TISSUES AND USE THEREOF - The invention relates to a bioactive surface comprising a polymer matrix, a connecting complex comprising at least one compound covalently bound to the surface of the polymer matrix, and a gene transfer vector bound to the connecting complex, wherein the compound of the complex is covalently bound to the transfer vector using a group selected from among carboxyl, amino, isocyanate and hydroxyl. The invention also relates to the use of the bioactive surface for transferring a nucleic acid to a cell. The invention further relates to: an implantable device characterized in that at least part of the surface thereof is coated with said bioactive surface, and to the use of the implantable device for transferring a nucleic acid to a cell. In addition, the invention relates to a method for transferring a nucleic acid to a cell and to a kit for performing said method. | 2014-01-23 |
20140023712 | Aqueous Transparent Oil-In-Water Emulsion Comprising an Emulsified Carotenoid - The invention relates to an aqueous transparent oil-in-water emulsion comprising a carotenoid and a process for producing said emulsion. | 2014-01-23 |
20140023713 | CLATHRATE COMPLEX OF CYCLODEXTRIN OR ARABINOGALACTAN WITH 9-PHENYL-SYM-OCTA-HYDROSELENOXANTENE - The invention relates to novel clathrate complexes of cyclodextrin or arabinogalactan with 9-phenyl-sym-octahydroselenoxanthene, possibly in α-crystalline form, The clathrate complex may be in crystalline form, possibly in the form of nano-particles. In the clathrate complex, cyclodextrin is selected from α-, β-, γ- or hydroxypropyl-β-cyclodextrin, primarily β-cyclodextrin. The proposed clathrate complexes make it possible to increase the water-solubility of the active compound, to improve the bioavailability, to reduce the dosage of the drug and, consequently, to reduce the toxic effect of 9-phenyl-sym-octahydroselenoxanthene. The complexes exhibit cytoradioprotective activity. The invention also relates to a liquid-phase and solid-phase methods for producing clathrate complexes, as well as to pharmaceutical compositions and drugs thereof. | 2014-01-23 |
20140023714 | HEMOSTATIC COMPOSITIONS - The invention relates to a hemostatic composition in powder form comprising collagen of the fibrillar type comprising a content of fibrous collagen and/or fibrillar collagen of at least 70% by weight relative to the total weight of the collagen, and at least one monosaccharide, and optionally, at least one compound selected from coagulation factors and glycosaminoglycans. The invention further relates to a method for preparing such composition, and to a unit comprising such composition and a spraying device. | 2014-01-23 |
20140023715 | POLYMER CONJUGATES TARGETING CELLS AND METHODS RELATED THERETO - This disclosure relates to polymer coated particles targeting cancer cells and methods related thereto. In certain embodiments, the disclosure relates to nanoparticles coated with amphiphilic polymers conjugated with molecules useful for targeting tumors, monitoring the location of the nanoparticles administered to a subject by MRI, and viewing the presence of the nanoparticles during optical image-guided surgery. | 2014-01-23 |
20140023716 | Pasty Bone Replacement Material - The present invention relates to a pasty composition, at least containing particles of at least one calcium salt, whereby the particles of the at least one calcium salt
| 2014-01-23 |
20140023717 | METHODS AND COMPOSITIONS FOR TREATING PROLIFERATIVE DISEASES - The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents, or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle composition based on a metronomic dosing regime. | 2014-01-23 |
20140023718 | PROSTAGLANDIN-CONTAINING FAT EMULSION - There is provided a fat emulsion which has a pH of 4.5 to 6.0 and includes a prostaglandin compound, an oil ingredient, a lecithin, the content of which is 0.15 times or more by mass the content of the oil ingredient, a water-soluble acid having a pKa of 4.0 to 6.0 and having a dissociable group or a salt thereof, and water; and a fat emulsion which includes a prostaglandin compound, an oil ingredient, a lecithin, the content of which is 500 to 5,000 times by mass the content of the prostaglandin compound and is 0.5 to 10 times by mass the content of the oil ingredient, and water, and in which the content of a higher fatty acid is 0.06 times or less by mass the content of the lecithin. | 2014-01-23 |
20140023719 | PLANT DERIVED SEED EXTRACT RICH IN ESSENTIALLY FATTY ACIDS DERIVED FROM SALVIA HISPANICA L. SEED: COMPOSITION OF MATTER, MANUFACTURING PROCESS AND USE | 2014-01-23 |
20140023720 | ENHANCED AUTOLOGOUS GROWTH FACTOR PRODUCTION AND DELIVERY SYSTEM - Systems and methods for producing enhanced blood serum with concentrated growth factors and/or prophylactically and therapeutically active proteins. An autologous blood product is obtained from a donor and then incubated into a containment device (sterile container) that includes a source of cells or tissue (for example, autologous, allogeneic, or xenographic tissue, or combinations thereof). The cells from the injected fluid (autologous blood product) interact/incubate with the source of cells or tissue inside the containment device, to produce a serum that is loaded with autologous proteins, growth factors, and cytokines. The autologous blood product may be a fluid and/or composition that includes blood, whole blood, autologous conditioned plasma, platelet-rich plasma, platelet-poor plasma, bone marrow aspirate, bone marrow concentrate and stem cells, among others, and combinations thereof. | 2014-01-23 |
20140023721 | METHOD OF EXTRACTING ACTIVE MOLECULES FROM NATURAL RESINS AND USE THEREOF - The present invention relates to a method of extracting active molecules from natural resins and/or essential oils. In particular, the present invention relates to a method of extracting active molecules selected from the group comprising terpenes, flavonoids, anthocyanins and catechins. Moreover, the present invention relates to an extract, preferably in liquid form, obtained with said method. Finally, the present invention relates to the use of said extract containing the active molecules selected from the group comprising terpenes, flavonoids, anthocyanins and catechins for the preparation of a food composition or supplement or a pharmaceutical composition. | 2014-01-23 |
20140023722 | Neural Scaffold Biomaterial - Disclosed herein are compositions and methods useful for preparing neural scaffolds. The neural scaffold biomaterial comprises tissue taken from the spinal cord of a vertebrate and can be processed to form gels or sheets. Methods of treating patient with CNS injury are also presented. | 2014-01-23 |
20140023723 | Decellularized Extracellular Matrix - Methods for producing compositions of decellularized extracellular matrix (DM) tissue culture are described. The compositions can be used for coating supports such as tissue culture substrates, osteogenic gels, and medical devices. | 2014-01-23 |
20140023724 | METHOD FOR PRODUCING REDUCED WATER AND APPARATUS FOR PRODUCING REDUCED WATER - The problem of the present invention is to provide a method or the like for producing reduced water (hydrogen-enriched water), which is effective for various diseases caused by active oxygen, more efficiently than the conventional methods, by putting metallic magnesium or the like in water. Adding a metal such as magnesium, together with a solid phase contained in an anode of an oxidation-reduction reaction, to water increases the saturating amount of magnesium ions, and improves deterioration due to magnesium hydroxide being precipitated on the surface of the metallic magnesium. Thus, the abovementioned problem is solved. | 2014-01-23 |
20140023725 | Biocompatible, Biodegradable Polyurethane Materials With Controlled Hydrophobic to Hydrophilic Ratio - The biocompatible, biodegradable materials in the solid and/or liquid form are based on segmented linear polyurethanes and/or segmented crosslinked polyurethanes based on A) one or more biocompatible polyols susceptible to hydrolytic and/or enzymatic degradation having a molecular weight of 100 to 20,000 dalton and a number of active hydroxyl groups per molecule (functionality) of at least two or higher; B) one or more diisocyanates and/or triisocyanates; and C) one or more low molecular weight chain extenders having a molecular weight of 18 to 1000 dalton and the functionality of at least two or higher. | 2014-01-23 |
20140023726 | POLYMORPHISMS PREDICTIVE OF PLATINUM-COORDINATING COMPLEX INDUCED OTOTOXICITY - Provided are methods, nucleic acids, and arrays for assessing the susceptibility of a subject to the development of ototoxicity in response to receiving one or more platinum-coordinating compounds, the method including determining the presence or absence of one or more polymorphisms, wherein the presence or absence of one or more such polymorphisms is indicative of susceptibility to the development of ototoxicity. | 2014-01-23 |
20140023727 | COMPOSITIONS OF DIBROMOMALONAMIDE AND THEIR USE AS BIOCIDES - A biocidal composition comprising 2,2-dibromomalonamide and an oxidizing biocide, and its use for the control of microorganisms in aqueous and water-containing systems. | 2014-01-23 |
20140023728 | Iodine Liquid Soap, Dispenser and Method - A iodine liquid soap dispenser having a reservoir containing an iodine solution. The dispenser has a head communicating with the reservoir capable of delivering the solution to the exterior of the reservoir in the form of foam. The solution comprises water, iodine and iodide, and contains iodine in a range of concentration between 0.35% and 0.05% by weight of the solution. The solution may also contain one or more of the following: an anionic surfactant, Hydrogen Iodide, glycerine, and sodium hydroxide. | 2014-01-23 |
20140023729 | Nutritional supplement for disinhibiting therapy of psychiatric patients - The present invention is a composition and methods of administering the composition to improve a person's mental and physical health by increasing energy levels, motivation, willingness to communicate, appetite, and memory. The composition may be used to treat mental conditions by improving a person's wiliness and ability to communicate. The increase in appetite effect of the composition may be used to treat eating disorders. The composition comprises a carbohydrate, one or more NAD+/NADP+ producing vitamins, poly-sulfurous chelating agents, vasodilating salts, coenzyme-A producing vitamins, antioxidants, kinins, and biological energy sources. | 2014-01-23 |
20140023730 | SODIUM NITRITE-CONTAINING PHARMACEUTICAL COMPOSITIONS - Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite. | 2014-01-23 |
20140023731 | COMPOSITION FOR TREATING AIDS AND ASSOCIATED CONDITIONS - An Aids and associated conditions related to Aids treating compositions is disclosed. The compositions comprise: a medicament selected from an extract of at least one of the following plant families: Apocynaceae ( | 2014-01-23 |
20140023732 | USE OF A TRADITIONAL CHINESE MEDICINE COMBINATION IN PREPARATION OF ANTI-ENTEROVIRUS 71 DRUG - Disclosed is a use of a pharmaceutical composition in preparation of anti-enterovirus 71 agents. | 2014-01-23 |
20140023733 | INSECT AND DISEASE CONTROL - The invention provides a method for controlling pests or pathogenic organisms in an agricultural structure, the method comprising applying a pesticidal composition to surfaces susceptible to infestation or colonization by the pest or pathogenic organism, wherein the composition includes terpenoids, essential oils, plant extracts, or combinations thereof. | 2014-01-23 |
20140023734 | Hair Care Compositions for Promoting Hair Growth and Preventing Hair Loss - A hair care composition that prevents hair loss and stimulates hair growth is disclosed. The hair care composition of the present invention comprises natural ingredients including one and/or more carrier oils, one and/or more essential oils, and fragrance oil. The preferred embodiment including Shea Butter, Extra Virgin Olive oil, Jojoba oil, Vanilla fragrance oil, Peppermint essential oil, Lavender essential oil, Tea Tree essential oil, Clary Sage essential oil, and Rosemary essential oil is provided. | 2014-01-23 |
20140023735 | PPAR Activator - Use of an organic solvent extract of a tempeh-fungus-fermented soybean product for the production of a PPARα and/or PPARδ activator. A method for activating PPARα and/or PPARδ, the method comprising administering an organic solvent extract of a tempeh-fungus-fermented soybean product to a subject, or feeding the organic solvent extract to the subject. | 2014-01-23 |
20140023736 | USE OF A COMPOSITION CONTAINING OILS OF CHAMOMILE FLOWER AND BLACK CUMIN WITH REDUCED ENDOTOXINS - A composition comprising an aqueous extract of camomile flowers is useful for the treatment of a proliferative and/or inflammatory condition. | 2014-01-23 |
20140023737 | Modulation of Oxidative Stress, Inflammation, and Impaired Insulin Sensitivity with Grape seed Extract - Method for modulating oxidative stress, inflammation, and impaired insulin sensitivity in a subject by using a grape seed extract, the method being useful in modulating post-prandial oxidative stress, inflammation, and impaired insulin sensitivity in patients suffering from Metabolic Syndrome (MetS). | 2014-01-23 |
20140023738 | PHARMACEUTICAL COMPOSITION USING STRYPHNODENDRON EXTRACTS FOR TREATING HPV INFECTIONS - The application of extracts, mainly the alcoholic, hydroalcoholic, and aqueous extracts of the bark, bark seam, stem, and seedpod skin of | 2014-01-23 |
20140023739 | METHOD OF MANUFACTURING MOLD FOR TIRE VULCANIZATION AND MOLD FOR TIRE VULCANIZATION - A vulcanizing mold manufacturing method, and a tire vulcanizing mold are disclosed. Tubular bodies each formed by oppositely arranging the inner peripheral surfaces of both end portions of a plate-shaped body are each arranged so that the gap between both opposite end portions thereof is narrowed and that the tips of both end portions come in contact with the surface of the plaster mold, by inserting and fitting both opposite end portions into a fitting portion of a plate-shaped metal fitting protruding from the surface of the plaster mold. Molten metal is poured over the surface of the plaster mold to embed the tubular body in a mold while exposing the tips of both opposite end portions at the tire molding surface of the mold. The metal fitting is removed from the mold, so that a mold having a small gap between both opposite end portions is manufactured. | 2014-01-23 |
20140023740 | PRESS-FORMING MOLD AND METHOD FOR MANUFACTURING PROTECTIVE FILM FOR PRESS-FORMING MOLD - A press-forming mold has a protective film for preventing seizing during press-forming formed on at least a forming surface that comes into contact with a formed body. The protective film is formed by PVD. An arbitrary selection section extracted from the surface of the protective film is divided into a plurality of individual sections; and, when the gradient of the surface at the n | 2014-01-23 |
20140023741 | MACHINE FOR CONTINUOUS CASTING OF PRE-MORTARED MASONRY PANELS - A machine for continuous casting of pre-mortared masonry panels includes a rotatable continuous mold for continuously forming pre-mortared masonry panels and an application system for applying polymeric material to the continuous mold as the continuous mold rotates. The machine also includes a brick setter system for setting bricks onto the polymeric material as the continuous mold rotates. The machine further includes a cutting device for cutting the bricks and polymeric material into panels to form the pre-mortared masonry panels. | 2014-01-23 |
20140023742 | DOUBLE COLOR INJECTION MACHINE WITH SHAFT AND DISC - A double color injection machine with a shaft and a disc is revealed. | 2014-01-23 |
20140023743 | MODULAR PLASTICS EXTRUSION APPARATUS - A modular plastic extrusion apparatus has several component parts. The design of the integration of those parts into a modular extrusion system is unique. Said design allows for rapid assembly, testing, disassembly and placement into production of extruded plastics. This modular plastic extrusion apparatus has several components with replaceable counterparts that, after one product line of a particular color has been extruded by the apparatus, enable the component parts used to produce the particular color extrusion to be removed from the apparatus and replaced with their clean counterparts to continue producing an extrusion product line of a different color while the removed components are cleaned off line. | 2014-01-23 |
20140023744 | Mold Assembly with Integrated Melting Device - A platen-supported system ( | 2014-01-23 |
20140023745 | Dough Packaging and Method for Dough Processing - The present invention provides a method for dough processing, a method for providing a container for a dough product, a container, and a product formed by a container. | 2014-01-23 |
20140023746 | Dough Packaging and Method for Dough Processing - The present invention provides a method for dough processing, a method for providing a container for a dough product, a container, and a product formed by a container. | 2014-01-23 |
20140023747 | Dough Packaging and Method for Dough Processing - The present invention provides a method for dough processing, a method for providing a container for a dough product, a container, and a product formed by a container. | 2014-01-23 |
20140023748 | NOVEL USE OF MALTOTRIOSYL TRANSFERASE - The present invention is intended to provide a novel use of a maltotriosyl transferase. The present invention provides a method for producing rice cakes or noodles, including a step of heat-treating a dough containing maltotriosyl transferase thereby gelatinizing starch in the dough. The present invention also provides a method for producing an indigestible saccharide, including a step of allowing maltotriosyl transferase to act on a saccharide. | 2014-01-23 |
20140023749 | FLAVOR-ENHANCING LACTOBACILLUS RHAMNOSUS - The present invention relates to a composition suitable for preparing a dairy product comprising at least one starter culture and a | 2014-01-23 |