04th week of 2010 patent applcation highlights part 41 |
Patent application number | Title | Published |
20100021933 | CELLOMICS SYSTEMS - In labeling a cell, and separating and collecting the cell according to a degree of the labeling using a cell separator, effects on the cell is minimized and the use of the collected cell is facilitated, thereby, when labeling a cell, the cell is labeled in the state where interaction of each cell is retained. In the labeling, a specific labeling material present on a surface of a target cell is taken in the cell via a transporter, and the cell is dispersed one by one to separate the same with a cell separator. Immediately after the separation, the cell is put in a solution not containing the specific labeling substance to remove the specific labeling substance taken in the cell. This series of steps is continuously conducted with a cell separation chip. | 2010-01-28 |
20100021934 | Perlecan Fragments as Biomarkers of Bone Stromal Lysis - A method for the detection in a body fluid of perlecan polypeptide fragments that are biomarkers of tumor metastasis, and antibodies for detecting these fragments are described. An immunoassay kit for detecting the presence of these biomarkers in a body fluid, such as serum or urine, is also described. | 2010-01-28 |
20100021935 | Goodpasture Antigen Binding Protein and Its Detection - The present invention provides native Goodpasture antigen binding protein isoforms, monoclonal antibodies directed against such proteins, and methods for their use. | 2010-01-28 |
20100021936 | Sensor for Spores - A sensor for spores, comprises spore-binding ligands and, on or within the body of the sensor, a material that is responsive to Ca-DPA (calcium-dipicolinic acid) but not to a (or another) germinant. | 2010-01-28 |
20100021937 | METHOD FOR DETECTING PATHOGENS USING MICROBEADS CONJUGATED TO BIORECOGNITION MOLECULES - A method and system are provided for the simultaneous detection and identification of multiple pathogens in a patient sample. The sample is combined with microbeads, which have been injected with quantum dots or fluorescent dye and conjugated to pathogen-specific biorecognition molecules, such as antibodies and oligonucleotides. Treatment options may be determined based on the identities of the pathogens detected in the sample. | 2010-01-28 |
20100021938 | Diagnosis and Prediction of Alzheimer's Disease - Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β peptide (Aβ) in the brain. Aβ is derived from amyloid precursor protein (APP) by β- and γ-secretases, with the β form (sAPPβ) being associated with the disease state, and the α form (sAPPα) being associated with the non-disease state. The present inventor proposes that defined the ratio of sAPPα to sAPPβ or the ratio of CTFα to CTFβ provide and accurate diagnosis of the disease, as well as a predictor for asymptomatic patients at risk of developing AD. In addition, drug screening and monitoring of treatment effectiveness can exploit this same sAPPα/sAPPβ or CTFα/CTFβ ratio. | 2010-01-28 |
20100021939 | PROCESS FOR DETECTING ENZYME ACTIVITY IN AN IMMUNOASSAY - The invention relates to a process for detecting enzyme activity in an immunoassay comprising the following steps: | 2010-01-28 |
20100021940 | Method for Determining the Activity of a Protease in a Sample - There is provided a method for determining the activity of a protease in a sample. The method comprises (i) admixing said sample with a substrate, wherein the substrate has the formula (1a) wherein: R | 2010-01-28 |
20100021941 | METHODS OF IDENTIFYING MODULATORS OF UBIQUITIN LIGASES - Methods for identifying ubiquitin ligases and ubiquitin ligase modulators are disclosed. The methods comprise combining the components of a ubiquitylation reaction and using proteins that contain motifs that recognize ubiquitylated sites in the detection of ubiquitylation. | 2010-01-28 |
20100021942 | Cell-free expression system for the detection of bacterial biofilms - Provided is a cell-free expression system and method for its use for detecting the presence of a bacterial biofilm on a surface, wherein the film comprises a) an exogenous quorum sensing protein or an exogenous nucleic acid sequence coding for a quorum sensing protein capable of selectively binding to a bacterial signaling molecule; and b) an exogenous nucleic acid sequence comprising a promoter operably linked to a nucleic acid sequence coding for a marker protein, wherein the promoter is regulated by the binding of the quorum sensing protein to the bacterial signaling molecule. Further provided is an aerosol formulation, as well as an adhesive bandage, each of which may be used for detecting the presence of a bacterial biofilm on a surface, comprising the disclosed cell free expression system and methods therefor. | 2010-01-28 |
20100021943 | Methods for differentially detecting a multimeric form from a monomeric form of a multimer-forming polypeptide through three-dimensional interactions - The present invention relates to a method for differentially detecting a multimeric form from a monomeric form of a multimer-forming polypeptide in a biosample, which comprises the steps of: (a) preparing a carrier-capturing antibody conjugate by binding a capturing antibody to the surface of a solid phase carrier in a three dimensional manner, wherein the capturing antibody is capable of recognizing an epitope on the multimer-forming polypeptide; (b) preparing a detection antibody, wherein an epitope recognized by the detection antibody is present at a position in the multimer-forming polypeptide to cause a steric hindrance by the capturing antibody bound to its epitope to prevent the binding of the detection antibody to the multimer-forming polypeptide; (c) contacting simultaneously the carrier-capturing antibody conjugate and the detection antibody to the biosample; and (d) detecting the formation of a carrier-capturing antibody-multimeric form-detection antibody complex. | 2010-01-28 |
20100021944 | Method for Decreasing Interference in Results of Immunochemical Methods - Methods and materials are provided for decreasing or eliminating interference from molecules resulting from upstream immunochemical procedures, such as Immunoprecipitation, that employ an Immunoglobulin Binding Molecule (an IBM, e.g., Protein A) in subsequent downstream methods, such as Western Blot. An effective amount of a ligand of the IBM is used to block the IBM or fragments of the IBM on a support membrane used in the downstream method. In another embodiment, a secondary antibody that is specific either for heavy chain or light chain antibody fragments or that recognizes intact antibody molecules but does not recognize individual antibody fragments may be employed with the ligand of the IBM. | 2010-01-28 |
20100021945 | DETERMINATION OF CHANGES IN CONCENTRATION - The invention relates to the field of macrocyclic host systems and fluorescent dyes. In particular, the invention relates to apparatuses and methods for determining a change in the concentration of an analyte, in particular as a result of a catalysed reaction, preferably an enzymatically catalysed reaction and preferably in an aqueous solution (>50% by weight water). | 2010-01-28 |
20100021946 | METHOD FOR PREPARING STANDARD SERUM MIXTURE FOR DETERMINING ALLERGEN ACTIVITY AND THE USE THEREOF - A method for preparing standardized serum mixture for determining allergen potency which comprises: 1) providing multiple serum samples from patients moderately hypersensitive to said allergen; 2) determining the relative content of sIgE against said allergen in each serum sample, obtaining the mean value of the relative content of sIgE of said multiple serum samples, and obtaining deviation value of the relative content of sIgE of each serum with respect to said mean value; 3) removing at least 5% of serum samples that have the largest and smallest deviation values respectively, and mixing the residual sera in the same volume. A serum mixture prepared by the method as well as the use of such serum mixture are also described. | 2010-01-28 |
20100021947 | Detection meter and mode of operation - A method for performing an assay to determine the presence or concentration of an analyte contained in a sample of body fluid by using a device comprising at least one analyte quantification member and a sensor associated therewith, the method includes: applying a first sample to the analyte quantification member; and detecting the presence or absence of an adequate sample volume; wherein upon detection of the absence of an adequate sample volume, initiating a finite timed period, and signaling the user to introduce a second sample of body fluid to the analyte quantification member. Associated arrangements and devices are also disclosed. | 2010-01-28 |
20100021948 | Medical diagnostic devices and methods - A medical diagnostic device includes a wirelessly transmitted time data receiver and processor. Associated devices, methods and functionality are also described. | 2010-01-28 |
20100021949 | Method for Detecting Transferase Enzymatic Activity - Methods and kits for detecting transferase activity in a sample by measuring ATP using a composition comprising an ATP-dependent bioluminescence-generating enzyme, a luminogenic molecule and one or more transferase quenching agents. | 2010-01-28 |
20100021950 | SCREENING METHOD FOR ANTI-DIABETIC COMPOUNDS - The present invention relates to a method of identifying a compound suitable as a lead compound and/or as a medicament for the treatment and/or prevention of diabetes, the method comprising the steps of (a) contacting a test compound with a cell comprising a protein, wherein said protein (i) comprises or consists of the amino acid sequence of any one of SEQ ID NOs: 1 to 29; (ii) is encoded by a nucleic acid molecule comprising or consisting of the sequence of any one of SEQ ID NOs: 59 to 87; (iii) is a fragment of the protein according to (i) or (ii) and exhibits Eph-Receptor-Tyrosine-Kinase activity; or (iv) has a sequence at least 75% identical with the protein according to (i) or (ii) or with the fragment according to (iii) and exhibits Eph-Receptor-Tyrosine-Kinase activity; and (b) determining whether said test compound, upon contacting in step (a) inhibits the Eph receptor tyrosine kinase activity of said protein wherein said inhibition indicates a compound suitable as a lead compound and/or as a medicament for the treatment and/or prevention of diabetes. | 2010-01-28 |
20100021951 | Human Brain Carboxypeptidase B - A novel carboxypeptidase and the encoding gene thereof were successfully identified by screening a human hippocampus extract using brain-APP-cleaving activity as an index. This protein and its gene are useful in, for example, preventing, treating, examining, and diagnosing Alzheimer's disease, and such. | 2010-01-28 |
20100021952 | Tetrahymena bifunctional dihydrofolate reductase-thymidylate synthase deficiency and its use - A method for producing a ciliate cell with reduced or essentially no dihydrofolate reductase (DHFS) activity or reduced or essentially no thymidylate synthase (TS) activity or both reduced or essentially no dihydrofolate reductase and thymidylate synthase (DHFR-TS) activity is claimed, comprising the steps of
| 2010-01-28 |
20100021953 | Method for Identifying an Agent that Modulates Arginine Transport in a Chondrocyte - The present invention relates to an assay method for identifying an agent that modulates arginine transport in a chondrocyte comprising the steps of: (a) identifying an agent that modulates the activity and/or expression of CAT-2; and (b) measuring arginine transport in the chondrocyte in the presence or absence of said agent, wherein a difference between: (a) arginine transport in the absence of the agent; and (b) arginine transport in the presence of the agent is indicative that the agent can modulate arginine transport in a chondrocyte. Therapeutic agents that modulate the expression or activity of CAT-2B could be beneficial for the treatment of inflammatory diseases, particularly osteoarthritis. For example, a CAT-2B antagonist may be useful for the treatment of osteoarthritis. | 2010-01-28 |
20100021954 | High capacity nanoparticulate immobilization surface - Disclosed are modified substrates having polyglutaraldehyde nanoparticulates for use, for example, in binding biomolecules, and methods of making and using the modified substrates. | 2010-01-28 |
20100021955 | MODELLING IN YEAST OF THE MITOCHONDRIAL ATP6 GENE MUTATIONS RESPONSIBLE FOR NARP SYNDROME IN HUMANS AND USES THEREOF FOR SCREENING FOR MEDICAMENTS - Modified yeast cells comprising at least one mutation of the tryptophan 136 (W | 2010-01-28 |
20100021956 | Fatty Acid Pattern Analysis for Predicting Acute Coronary Syndrome - The present invention provides blood based methods for predicting risk of acute coronary syndrome in a subject. | 2010-01-28 |
20100021957 | FUNCTIONALIZED QUANTUM DOTS AND METHODS FOR PREPARING THEM - A quantum dot (QD) conjugate comprises a QD and a ligand conjugated with the QD, in which the ligand has at least one thiol and at least one other functional group. The QD conjugate may further comprise a bioactive agent covalently coupled to the ligand to form a bioactive agent-tagged QD conjugate. A method for preparing a QD conjugate comprises the steps of: (1) providing a solution comprising a QD encapsulated within a dendrimer; (2) adding into the solution a ligand; and (3) allowing an exchange between the ligand and the dendrimer for the QD to obtain a ligand-QD conjugate, in which the ligand is covalently conjugated to the surface of the QD. The method may further comprise the step of coupling the ligand-QD conjugate to a bioactive agent to obtain a bioactive agent-tagged ligand-QD conjugate. | 2010-01-28 |
20100021958 | FLUORESCENT pH DETECTOR SYSTEM AND RELATED METHODS - Fluorescent pH detector and methods for measuring pH using the fluorescent pH detector. | 2010-01-28 |
20100021959 | High Throughput Screening Method for Assessing Heterogeneity of Microorganisms - The invention relates to the field of microbiology. Provided is a method which is particularly powerful for High Throughput Screening (HTS) purposes. More specific a high throughput method for determining heterogeneity or interactions of microorganisms is provided. | 2010-01-28 |
20100021960 | Methods and compositions for pathogen detection using fluorescent polymer sensors - Compositions, methods and related apparatus, as can be used for selective pathogen detection and identification. | 2010-01-28 |
20100021961 | METHOD FOR PREPARING BIOLOGICAL SCAFFOLD MATERIAL - Disclosed is a method for production of a bio-derived scaffold for use in regenerative medicine, which has a bio-compatibility and biodegradability and can self-organize and grow without causing calcification. The method comprises the steps of partially fixing a biological soft tissue with glutaraldehyde by cross-linking and incubating the partially fixed tissue together with an elastase. | 2010-01-28 |
20100021962 | Use of A Plastid-Lipid Associated Protein Promoter (PAP Promoter) For Heterologous Gene Expression - Use of a plastid-lipid associated protein promoter (PAP promoter) for heterologous expression of genes in plants of the genus | 2010-01-28 |
20100021963 | Genetic incorporation of unnatural amino acids into proteins in mammalian cells - The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins in mammalian host cells, for example, primate host cells and rodent host cells. The invention provides, for example but not limited to, translation systems that include host cells (e.g., primate or rodent cells), orthogonal aminoacyl-tRNA synthetases derived from eubacterial synthetases, orthogonal tRNAs, and the unnatural amino acid. The invention also relates to methods for producing proteins of interest comprising at least one unnatural amino acid in mammalian host cell systems. | 2010-01-28 |
20100021964 | MICROORGANISM FOR PRODUCING RECOMBINANT PIG LIVER ESTERASE - The present invention relates to a microorganism which comprises at least one copy of a polynucleic acid sequence which is foreign to the host and which encodes a protein having an enzymic activity, and comprises a chaperone system which assists the expression of the protein in the form of an active enzyme, and to a method for producing a protein having esterase activity using such a microorganism. | 2010-01-28 |
20100021965 | Protein Expression in Rodent Cells - A method is described for the expression of heterologous polypeptides in rodent cells. The method comprises the oriP/EBNA-1 episomal replication and maintenance system of the Epstein-Barr-Virus (EBV). With the stable integration of an EBNA-1-protein expression cassette under the control of a promoter into the genome of a rodent cell an EBNA-1-protein expression in the cells was obtained. The heterologous protein is expressed from an episome comprising an EBV origin of replication and a functional expression cassette of said heterologous protein. The invention further comprises transformed rodent cell lines, a method for the production of a heterologous protein in said cell lines and a kit for the construction of said cell lines. | 2010-01-28 |
20100021966 | Method for the Preparation of Growth Hormone and Antagonist Thereof Having Lower Levels of Isoform Impurities Thereof - The present invention is directed generally to recombinant methods for making a desired polypeptide. These method(s) yield a polypeptide product containing reduced levels of isoform impurities thereof. In particular, the present invention is directed to (1) a recombinant method for preparing growth hormone with reduced isoform impurities thereof and (2) a recombinant method for preparing a growth hormone antagonist, such as pegvisomant, and its protein intermediate, also having reduced isoform impurities thereof. More specifically, the isoform impurities that are decreased by methods of the present invention are the trisulfide and des-phe isoform impurities of growth hormone and growth hormone antagonist (or its intermediate), respectively. | 2010-01-28 |
20100021967 | Alpha Factor Signal Peptide For Producing a Polypeptide - The present invention relates to a method for producing a polypeptide comprising using a variant alpha factor signal peptide having a substitution in position 9 resulting in a substitution of an A to either T, S, H, I, F, E, or G. The invention further relate to nucleic acid constructs comprising a first nucleotide sequence encoding the variant signal peptide and a second nucleotide sequence encoding a polypeptide which is foreign to the first nucleotide sequence. Furthermore, it also relates to expression vectors and host cells comprising said nuclei acid construct. | 2010-01-28 |
20100021968 | NOVEL CHLORELLA SPECIES AND USES THEREFOR - The present invention relates to algal species and compositions, methods for identifying algae that produce high lipid content, possess tolerance to high CO | 2010-01-28 |
20100021969 | EXTRACTION OF PHYTOCHEMICALS BY ENZYMATIC HYDROLYSIS - A process for extracting phytochemicals from plants. The process generally comprises controllably slurrying a selected plant material in a volume, adding a selected enzyme the slurry while it is controllably agitated, then heating the controllably agitated slurry-enzyme mixture to a temperature from the range of 40° C. to 110° C., and then maintaining the slurry-enzyme mixture at that temperature for a selected period of time. The slurry is then separated into a solids fraction and a liquids fraction that contains extracted phytochemicals. The liquids fraction is controllably de-watered to produce a fluid extract concentrate. The liquids fraction may optionally be dried to produce a dried extract concentrate. Suitable enzymes for use with this process include α-amylases, β-amylases, endo-β-1,4-glucanases, cellobiohydrolases, cellulases, hemicellulases, β-glucosidases, β-xylosidases, xylanases, pullulases, esterases and mixtures thereof. | 2010-01-28 |
20100021970 | Nucleic Acid Amplification Using a Reversibly Modified Oligonucleotide - The present invention provides a method for amplification of a target nucleic acid sequence or signal, wherein an amplification reaction mixture is used which contains at least one reversibly modified oligonucleotide having a non-hydroxyl group 3′ end which can be converted into a hydroxyl 3′ end upon exposure to a chemical and/or irradiation and/or a range of temperature. The present invention also provides a reversibly modified oligonucleotide as described above, and a nucleic acid amplification reaction mixture and kit comprising such an oligonucleotide. | 2010-01-28 |
20100021971 | METHOD TO REMOVE REPETITIVE SEQUENCES FROM HUMAN DNA - The invention discloses an innovative method to deplete repetitive sequences from human DNA. The method comprises (a) providing a source DNA containing both unique and repetitive sequences and sonicating the source DNA to smaller fragments; (b) providing a driver DNA containing sequences complementary to the repetitive sequences of the source DNA and labeled with a non-radioactive label, (c) hybridizing the source DNA and the driver DNA in the presence of a molecule that binds the label to form a complex; (d) removing the hybridized repetitive sequences from the complex by using RNAase and electrophoresis or by incubating with a mixture of phenol, chloroform, and ethanol; and (e) recovering the remaining source DNA wherein said repetitive sequences being significantly removed. | 2010-01-28 |
20100021972 | METHOD AND APPARATUS FOR AMPLIFYING NUCLEIC ACIDS - A method and apparatus for amplifying nucleic acids. The method includes introducing into a reaction vessel via different inlet channels a reactant aqueous solution containing reactants for nucleic acid amplification and a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction, creating a plurality of reactant aqueous solution droplets surrounded by the fluid by contacting the reactant aqueous solution with the fluid in the reaction vessel, and amplifying the nucleic acids in the reactant aqueous solution droplets. The apparatus includes a substrate, a reaction vessel formed inside of the substrate, at least one first inlet channel formed inside the substrate, connected to an end of the reaction vessel, and allowing introduction of a reactant aqueous solution containing reactants for nucleic acid amplification into the reaction vessel, a second inlet channel formed inside the substrate, connected to the end of the reaction vessel, and allowing introduction of a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction into the reaction vessel, and a heating unit installed on the substrate in such a way to thermally contact with the substrate and heating the substrate. | 2010-01-28 |
20100021973 | COMPOSITIONS AND METHODS FOR PROCESSING AND AMPLIFICATION OF DNA, INCLUDING USING MULTIPLE ENZYMES IN A SINGLE REACTION - The present invention concerns preparation of DNA molecules, such as a library, using a stem-loop oligonucleotide. In particular embodiments, the invention employs a single reaction mixture and conditions. In particular, at least part of the inverted palindrome is removed during the preparation of the molecules to facilitate amplification of the molecules. Thus, in specific embodiments, the DNA molecules are suitable for amplification and are not hindered by the presence of the palindrome. | 2010-01-28 |
20100021974 | Method for Preparation of cRNA - It is an object of the present invention to provide a method for preparing a cRNA, the method being capable of preventing decrease in cRNA yield. In order to achieve the object, the method comprises (a) a step of performing a reaction for preparing a single-stranded cDNA by treating with RNaseH an mRNA-cDNA hybrid prepared by reverse transcription and a reaction for preparing a double-stranded cDNA from the single-stranded cDNA and then inactivating the RNaseH contained in the resultant reaction solution; (b) a step of contacting the reaction solution with a solid support having a cationic group on its surface under pH conditions where the cationic group is positively charged; (c) a step of separating the solid support from the reaction solution; (d) a step of eluting the double-stranded cDNA from the solid support; and (e) a step of performing a transcription reaction for preparing a cRNA from the double-stranded cDNA. | 2010-01-28 |
20100021975 | Process For Producing Xylo-Oligosaccharides - The invention relates to a process for producing xylo-oligosaccharides, comprising the steps of cold caustic extraction (CCE) of a pulp obtained by a cooking process; purifying at least a portion of the press liquor forming in the cold caustic extraction stage using a membrane separation process, preferably nano- or ultrafiltration; obtaining the xylans from at least a portion of the retentate of the membrane separation process; processing at least a portion of the xylans obtained into xylo-oligosaccharides. | 2010-01-28 |
20100021976 | PRODUCTION OF POLYUNSATURATED FATTY ACIDS, NOVEL BIOSYNTHESIS GENES, AND NOVEL PLANT EXPRESSION CONSTRUCTS - The present invention relates to a method for the production of unsaturated fatty acids with at least two double bonds. The invention furthermore relates to the use of nucleic acid sequences SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 11 encoding polypeptides having desaturase activity in the method and for generating a transgenic organism, preferably a transgenic plant or a transgenic microorganism, with an increased content of fatty acids, oils or lipids with unsaturated C | 2010-01-28 |
20100021977 | PROCESS FOR PREPARING ALKYL (METH)ACRYLATES USING AN ENZYMATIC CYANOHYDRIN HYDROLYSIS - The present invention relates to a process for preparing alkyl(meth)acrylates, characterized in that the process has a step in which a cyanohydrin is hydrolysed with an enzyme whose residual activity after the conversion of methacrylonitrile in the presence of 20 mM cyanide ions at 20° C. after 30 min is at least 90% of the residual activity of the enzyme which has been used under otherwise identical conditions in the absence of cyanide ions. | 2010-01-28 |
20100021978 | METHODS AND ORGANISMS FOR PRODUCTION OF 3-HYDROXYPROPIONIC ACID - A non-naturally occurring microbial organism having a 3-hydroxypropanoic acid (3-HP) pathway includes at least one exogenous nucleic acid encoding 3-HP pathway enzyme expressed in a sufficient amount to produce 3-HP. The 3-HP pathway includes a 2-keto acid decarboxylase, a CoA-dependent oxaloacetate dehydrogenase, or a malate decarboxylase. A method for producing 3-HP includes culturing a non-naturally occurring microbial organism having a 3-HP pathway that includes at least one exogenous nucleic acid encoding a 3-HP pathway enzyme expressed in a sufficient amount to produce 3-HP under conditions and for a sufficient period of time to produce 3-HP. The 3-HP pathway includes a 2-keto acid decarboxylase, a CoA-dependent oxaloacetate dehydrogenase, or a malate decarboxylase. | 2010-01-28 |
20100021979 | Apparatus and Process for Production of Biogas - A process and an apparatus for the manufacture of biogas and a solids fraction from an organic waste feedstock is provided. The process involves thermal hydrolysis of the organic waste feedstock at a temperature from about 100 to about 220° C., a pressure from about 5 to about 20 bars, for a period of time from about 15 minutes to 4 hours, to produce a hydrolysate. The hydrolysate undergoes anaerobic digestion at a temperature from about 25 to 60° C., for a period of time from about 1 to 35 days to produce a biogas stream and a digestate. The digestate is separated into a solids fraction and a liquid fraction, and a portion of the solids fraction is recycled for further anaerobic digestion. The biogas stream, characterized as having a methane content from between 55 to 80% by volume, and the solids fraction, are recovered. The apparatus includes a receiving bin for receiving and supplying organic waste feedstock to a thermal hydrolysis reactor. The thermal hydrolysis reactor for processing the organic waste feedstock at a temperature from about 100 to about 220° C., a pressure from about 5 to about 20 bars, for a period of time from about 15 minutes to 4 hours to produce a hydrolysate. An anaerobic digester for processing the hydrolysate at a temperature from about 25 to 60° C., for a period of time from about 1 to 35 days to produce the biogas and a digestate, and a solids thickening tank for separating the digestate into the solid fraction, a liquid fraction and a secondary biogas fraction. | 2010-01-28 |
20100021980 | HYBRID PROCESS FOR THE PRODUCTION OF BIOFUEL - A method of producing a biofuel from biomass is provided. In one embodiment, the biofuel production process is an ethanol production process. Various embodiments of the invention include features such as application of a shock wave to biomass, variations in composition of biomass feed stock, continuous fermentation, and anaerobic digestion of stillage to produce a methane based fuel. | 2010-01-28 |
20100021981 | Process and a plant for recycling carbon dioxide emissions from power plants into useful carbonated species - A process is disclosed for recycling carbon dioxide emissions from a fossil-fuel power plant into useful carbonated species The process primarily comprises the steps of: a) burning the fossil fuel, thereby generating heat and a hot exhaust gas containing CO | 2010-01-28 |
20100021982 | LIGHT-SENSITIVE CONSTRUCTS FOR INDUCING CELL DEATH AND CELL SIGNALING - A light-sensitive G-protein coupled receptor includes a light sensitive extracellular domain and a hetorologous intracellular domain capable of modulating an intracellular signaling pathway. | 2010-01-28 |
20100021983 | Laser Dosimetry for the Optoperforation of Single Cells - A method of optoperforation of the membrane of a cell by application of laser pulses characterized by focusing the pulsed laser beam onto the cell membrane to be perforated, applying a series of laser pulses of predetermined pulse energy, measuring the oscillation time of the bubbles formed in the laser focus from the change in laser intensity of a test laser beam transmitted through the laser focus and caused by the bubbles in the laser focus, and increasing the pulse energy to a level at which the oscillation time of the bubbles attains a predetermined value. | 2010-01-28 |
20100021984 | Microfluidic Droplet Encapsulation - Microfluidic devices and methods for the encapsulation of particles within liquid droplets are disclosed. The new methods and devices form 1-100 picoliter-size monodisperse droplets containing the particles, such as single cells, encapsulated in individual liquid droplets. The particles can be encapsulated in droplets of a fluid by passing a fluid containing the particles through a high aspect-ratio microchannel to order the particles in the fluid, followed by forming the fluid into droplets. The resulting fraction of the liquid droplets with a single particle (e.g., a cell) is higher than the corresponding fraction of single-particle liquid droplets predicted by Poisson statistics. | 2010-01-28 |
20100021985 | MECHANICAL PROCESS FOR CREATING PARTICLES IN FLUID - A method of producing at least one of microscopic and submicroscopic particles includes providing a template that has a plurality of discrete surface portions, each discrete surface portion having a surface geometry selected to impart a desired geometrical property to a particle while being produced; depositing a constituent material of the at least one of microscopic and submicroscopic particles being produced onto the plurality of discrete surface portions of the template to form at least portions of the particles; separating the at least one of microscopic and submicroscopic particles comprising the constituent material from the template into a fluid material, the particles being separate from each other at respective discrete surface portions of the template; and processing the template for subsequent use in producing additional at least one of microscopic and submicroscopic particles. A multi-component composition includes a first material component in which particles can be dispersed, and a plurality of particles dispersed in the first material component. The plurality of particles is produced by methods according to embodiments of the current invention. | 2010-01-28 |
20100021986 | APPARATUS AND METHOD FOR INTRODUCING SUBSTANCE INTO CELLS - Provided is a cell chip for exposing to a portion of each of cells microdroplets dispensed with an inkjet printer or the like in a screening test of the effect of a substance on cells by using an apparatus for introducing the substance into cells including: a cell-immobilizing support including a substrate having through-holes penetrating from one side to the other side of the substrate and including cells immobilized in the through-holes so as to block up the through-holes; a liquid phase region present in contact with one side of the support and including a medium of the cells; and a mechanism present so as to face the other side of the support and imparting a microdroplet to a portion of each of the cells exposed in the openings on the other side. | 2010-01-28 |
20100021987 | Compositions, Methods, and Kits for Enhancing Protein Expression - The inventive subject matter relates to novel compositions, methods, and kits for enhancing the expression, solubility, and isolation of heterologous proteins. Further, the inventive subject matter relates to methods for generating proteins with novel N-terminal amino acids, unlike wild-type proteins which always are translated from mRNA with methionine at the N-terminus. | 2010-01-28 |
20100021988 | PECTATE LYASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM - The invention is directed to polypeptides having pectate lyase (pectinase) activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used as pectate lyases to catalyze the beta-elimination or hydrolysis of pectin and/or polygalacturonic acid, such as 1,4-linked alpha-D-galacturonic acid. The invention provides methods of treating fibers, fabrics or any pectate- or polygalacturonic acid-comprising material using one or more pectate lyases of the invention. | 2010-01-28 |
20100021989 | COMPOSITIONS AND METHODS OF CONTROLLING AND ADMINISTERING REDOX SPECIFIC FORMS OF DRUGS, FOODS AND DIETARY SUPPLEMENTS - The formulations have an antimicrobial, antiviral, and anti-pathogenic composition that combines, in various forms, a redox-active polyphenol, an oxidizing agent, and/or a redox-active, transition metal ion and/or electrochemical potential. The composition relates to methods for decreasing or eliminating the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for treating herpes simplex and HIV viruses and drug-resistant bacteria, and for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods, compositions, electrochemical devices, and storage containers for decreasing the infectivity of pathogenic organisms in pharmaceuticals, medical devices, personal care products, recreational products, and foodstuffs. | 2010-01-28 |
20100021990 | HIGH THROUGHPUT BIOPROCESS APPARATUS - The invention relates to a multiple bioreactor system comprising a plurality of bioreactors, a source of pressurised fluid, and distribution means for distributing the fluid to the bioreactors, wherein the bioreactor system includes backpressure creating means presented by, before or after each bioreactor and the source of pressurised fluid such that each backpressure creating means provides a resistance to the flow of the pressurised fluid which is greater than the resistance to flow between each backpressure creating means. The invention further relates to A method of operating a multiple bioreactor system comprising providing a plurality of bioreactors, a source of pressurised fluid, and distribution means for distributing the fluid to the bioreactors, wherein the bioreactor system includes backpressure creating means presented by each bioreactor or located between each bioreactor and the source of pressurised fluid such that each backpressure creating means provides a resistance to the flow of the pressurised fluid which is greater than the resistance to flow between each backpressure creating means and operating the system. | 2010-01-28 |
20100021991 | Methods for Producing Modified Glycoproteins - Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts. The lower eukaryotes, which ordinarily produce high-mannose containing N-glycans, including unicellular and multicellular fungi are modified to produce N-glycans such as Man | 2010-01-28 |
20100021992 | ENZYMATIC DECOMPOSITION OF RESIDUAL FORMAMIDE IN POLYMERS - Method for reducing the formamide content of preparations (P) prepared from N-vinylformamide monomers by polymerization. | 2010-01-28 |
20100021993 | SYSTEM FOR ASSEMBLING AND UTILIZING SENSORS IN CONTAINERS - A system for measuring parameters in a container is disclosed. A container has a solution. A protective layer is deposited over at least one sensor and at least one wall of the container, where the protective layer is attached to the wall of the container to form a seal between the container and the at least one sensor. The at least one sensor is configured to have an operable electromagnetic field based on a thickness of the container and the protective layer. The at least one sensor in conjunction with a tag is in proximity to an impedance analyzer and a reader that constitute a measurement device. The at least one sensor is configured to determine at least one parameter of the solution. The tag is configured to provide a digital ID associated with the at least one sensor, where the container is in proximity to the reader and an impedance analyzer. The impedance analyzer is configured to receive a given range of frequencies from the at least one sensor based on the measured complex impedance over the given range of frequencies. | 2010-01-28 |
20100021994 | APPARATUS FOR DETERMINING THE TERMINATION OF FAT DIGESTION AND FAT TISSUE DIGESTION APPARATUS - To enable to yield a group of fat-derived stem cells of constant quality regardless of the individual difference in fat tissue. It is intended to provide an apparatus for determining the termination of fat digestion ( | 2010-01-28 |
20100021995 | BIOLOGICAL PRODUCTS - There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human CD22. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by cells expressing CD22. | 2010-01-28 |
20100021996 | Genetically Altered Anti-body Producing Cell Lines With Improved Antibody Characteristics - Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. Cells may be selected for expression of activation-induced cytidine deaminase (AID), stimulated to produce AID, or manipulated to express AID for further enhancement of hypermutability. These methods are useful for generating genetic diversity within immunoglobulin genes directed against an antigen of interest to produce altered antibodies with enhanced biochemical activity. Moreover, these methods are useful for generating antibody-producing cells with increased level of antibody production. | 2010-01-28 |
20100021997 | Biologically active recombinant human saposin C and PSAP - The invention relates to the establishment of expression vectors replicable in a mammalian cell, including a DNA sequence encoding human prosaposin (PSAP) or Saposin C, operably linked with regulatory DNA capable of effecting the expression of the PSAP and Saposin C DNA coding sequence in the cells. In addition, the invention relates to mammalian cells (CHO-K1) stably transfected with such expression vectors and methods of producing human Saposin C or PSAP, including transfecting a mammalian cell with expression vectors, maintaining and propagating the cell in culture medium, and isolating soluble rh-Saposin C or rh-PSAP from the medium. Purified rh-Saposin C and rh-PSAP are useful as reagents for studying biological responses and signal transduction mechanism in benign or malignant cells, as standard proteins in diagnosis or screening of benign or malignant diseases, or as medicine for the treatment of diseases or disorders affecting musculoskeletal system or peripheral and central nervous system. | 2010-01-28 |
20100021998 | DEFINED CELL CULTURING SURFACES AND METHODS OF USE - In one aspect, there is provided a cell culturing substrate including: a cell culture surface having a film attached thereto, wherein the film includes one or more plasma polymerized monomers; and a coating on the film-coated surface, the coating deposited from a coating solution comprising one or more extracellular matrix proteins and an aqueous solvent, where the total extracellular matrix protein concentration in the coating solution is about 1 ng/mL to about 1 mg/mL. | 2010-01-28 |
20100021999 | Methods of preparing feeder cells-free, xeno-free human embryonic stem cells and stem cell cultures prepared using same - The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells. | 2010-01-28 |
20100022000 | Increasing Cell Culture Population Doublings for Long-Term Growth of Finite Life Span Human Cell Cultures - Cell culture media formulations for culturing human epithelial cells are herein described. Also described are methods of increasing population doublings in a cell culture of finite life span human epithelial cells and prolonging the life span of human cell cultures. Using the cell culture media disclosed alone and in combination with addition to the cell culture of a compound associated with anti-stress activity achieves extended growth of pre-stasis cells and increased population doublings and life span in human epithelial cell cultures. | 2010-01-28 |
20100022001 | Cationic Liposomes And Method of Use - Highly efficient cationic liposomes are provided as a system for the delivery to cells of agents or compounds, such as, compounds capable of silencing a target protein and enzyme substrates. The cationic liposomes can be used in methods of detecting the inhibition activity or apparent activity of a target protein in a cell, and methods of identifying a protein associated with a pathway, such as, a signal transduction pathway in a cell. | 2010-01-28 |
20100022002 | METHOD FOR INHIBITING THE FORMATION OF SET1 FAMILY CORE COMPLEXES - Disclosed in this specification is a method for inhibiting the formation of SET1 family core complexes. A guanidinium-containing molecule is used to competitively inhibit the binding of the N-SET region of a SET1 protein to WDR5, thus inhibiting the formation of the SET1 family core complex. The guanidinium-containing molecule may be, for example, an arginine-containing peptide. When bound to WDR5, the guanidinium moiety is bound between the F-133 and F-263 residues of the WDR5 when a crystal structure of the bound complex is obtained. | 2010-01-28 |
20100022003 | Therapeutic cell medicine comprising skin tissue derived stem cell - Provided is a cell therapeutic agent for treatment of neurological disorders, comprising skin-derived progenitor cells (SPCs). More specifically, the present invention provides a cell therapeutic agent for treatment of neurological disorders, comprising skin-derived progenitor cells (SPCs) isolated from skin tissues and a method for differentiation of the skin-derived progenitor cells (SPCs) into neural cell lineages. The cell therapeutic agent in accordance with the present invention is therapeutically effective for the treatment of the neurological disorders and diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease and Amyotrophic Lateral Sclerosis (ALS) caused by neural injury, and neurological deficits due to cerebral apoplexy, ischemia and spinal cord injury. Further, the present invention enables transplantation of autologous cells to thereby minimize adverse side effects. | 2010-01-28 |
20100022004 | MODIFIED RECONSTITUTED BASEMENT MEMBRANE COMPOSITION FOR ASSAY SYSTEM - A modified reconstituted extracellular matrix composition is provided herein. The composition includes an extracellular matrix and at least one exogenous component selected from heparin, fibronectin and laminin. The composition may have a basic pH. Additionally, provided herein is a cell culturing system including a substrate and a coating thereon of the composition to assess potential stimulators and/or inhibitors for their effects on various cell cultures while increasing the signal dynamic range. | 2010-01-28 |
20100022005 | ADIPOSE STROMAL STEM CELLS FOR TISSUE AND VASCULAR MODIFICATION - Methods are provided for isolating adipose derived stromal cells from an animal by extracting adipose tissue from the patient, dissecting the tissue, dissociating the tissue into a cell suspension, removing the adipocytes, exposing the cell suspension to red cell lysis buffer, and isolating adipose derived stromal cells. | 2010-01-28 |
20100022006 | GAMMA SATELLITE INSULATOR SEQUENCES AND THEIR USE IN PREVENTING GENE SILENCING - Regulatory elements, specifically insulators and transgene constructs containing insulator nucleic acid sequences, are disclosed herein. Methods of using insulators and transgene constructs including insulators to inhibit, delay, or prevent gene silencing are also disclosed herein. | 2010-01-28 |
20100022007 | MICROFLUIDIC DEVICE FOR PREPARING MIXTURES - A microfluidic device for preparing a mixture, has a mixer. The mixer includes a plurality of chambers, each chamber having a volume of at most 1 microliter, a first plurality of channels, each channel fluidly connecting 2 chambers, a plurality of chamber valves, each chamber valve controlling fluid flow out of one of the plurality of chambers, and a first plurality of channel valves, each channel valve controlling fluid flow through one of the first plurality of channels. | 2010-01-28 |
20100022008 | COMPOSITIONS AND METHODS FOR DETECTING NERVE AGENTS - The present invention provides methods and compositions for detecting, identifying and measuring the abundance of chemical nerve agents. Methods and compositions of the present invention are capable of providing selective detection of phosphorous based nerve agents, such as nerve agents that are esters of methyl phosphonic acid derivatives incorporating a moderately good leaving group at the phosphorus. Selectivity in the present invention is provided by a sensor composition having an alpha (α) effect nucleophile group that undergoes specific nucleophilic substitution and rearrangement reactions with phosphorus based nerve agents having a tetrahederal phosphorous bound to oxygen. The present invention includes embodiments employing a sensor composition further comprising a reporter group covalently linked to the alpha effect nucleophile group allowing rapid optical readout of nerve agent detection events, including direct visual readout and optical readout via spectroscopic analysis. | 2010-01-28 |
20100022009 | REMOTE IDENTIFICATION OF EXPLOSIVES AND OTHER HARMFUL MATERIALS - Embodiments of the present invention are generally directed to the remote detection of explosives and other harmful materials. In some such embodiments, such remote detection involves the use of semiconducting nanoparticles. In some or other such embodiments, such remote detection involves the use of photoacoustic detection and/or spectroscopy. In some such latter embodiments, the photoacoustic system comprises a light source | 2010-01-28 |
20100022010 | CHEMICAL AGENT DETECTION METHOD AND APPARATUS - A method and apparatus for detecting Chemical Warfare Agents (CWA) and Toxic Industrial Chemicals (TICs) that is simple, cost-effective, non-instrumental, and environmentally robust. Illustrative embodiments provide a material that responds by a color change and/or a change, in fluorescence when exposed to the toxic-chemical vapors. | 2010-01-28 |
20100022011 | DETERMINATION OF EXPLOSIVES INCLUDING RDX - The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. In some embodiments, the analyte and the emissive material may interact via a chemical reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be used for the detection of analytes such as explosives (e.g., RDX, PETN). Methods of the present invention may be advantageous in that the high sensitivity of luminescence (e.g., fluorescence) spectroscopy can allow for the reliable detection of small changes in luminescence intensity. | 2010-01-28 |
20100022012 | NANOSENSORS - Electrical devices comprised of nanowires are described, along with methods of their manufacture and use. The nanowires can be nanotubes and nanowires. The surface of the nanowires may be selectively functionalized. Nanodetector devices are described. | 2010-01-28 |
20100022013 | DIRECT MASS SPECTROMETRIC ANLAYSIS OF AGGREGATES OF THERAPEUTIC PROTEINS - The invention relates to a method of using high-mass matrix assisted laser desorption-ionization (MALDI) mass spectrometry for the quantitative analysis of the amount of aggregation (dimers, trimers or multimers) of antibodies or other therapeutic proteins in purified pharmaceutical samples or complex biological matrices, as well as to the use of this method for characterization of antibodies, drug development and quality control of therapeutic proteins, including automated high throughput applications. | 2010-01-28 |
20100022014 | Method for Evaluating Obesity Controller - A method for efficiently evaluating or selecting an obesity controlling substance, a blood insulin regulating substance or a blood sugar regulating substance, is provided. A method for evaluating or screening an obesity controller, the method including administering a carbohydrate and a lipid to an animal, and evaluating or selecting a substance which decreases or increases insulin secretion, is also provided. | 2010-01-28 |
20100022015 | Analysis of Mannosamine-containing Capsular Saccharides - Analysis of compositions that include saccharides having mannosamine residues, such as the capsular saccharide of | 2010-01-28 |
20100022016 | POLYAMIDE NUCLEIC ACID DERIVATIVES AND AGENTS, AND PROCESSES FOR PREPARING THEM - The present invention relates to PNA derivatives which carry, at the C terminus, or at both the C and N termini of the PNA backbone, one or more phosphoryl radicals. The phosphoryl radicals carry, where appropriate, one or more labeling groups, groups for crosslinking, groups which promote intracellular uptake, or groups which increase the binding affinity of the PNA derivative for nucleic acids. The invention furthermore relates to a process for preparing the above-mentioned PNA derivatives and to their use as pharmaceuticals or diagnostic agents. | 2010-01-28 |
20100022017 | Inorganic phosphate assays - Binding of inorganic phosphate to a phosphate binding protein can result in changes to the stacking of appropriately positioned chromophores, thereby resulting in a detectable change. The invention provides a phosphate-binding protein that undergoes a conformational change from an initial conformation to a final conformation upon binding of phosphate, wherein the protein carries a first label and a second label, and wherein the first and second labels are arranged such that they exhibit molecular stacking that is perturbed on changing from one conformation to the other. Preferred labels are rhodamines. | 2010-01-28 |
20100022018 | RAPID DETECTION OF SULFHYDRYL COMPOUNDS USING A PAPAIN BASED ASSAY - The invention relates to a method for detecting compounds containing a free sulfhydryl group in a sample and a test device which is used to detect such compounds. The method and test device use a papain-based assay where the papain is initially complexed with a metal ion making it inactive. Sulfydryl compounds in a sample activate the papain. Enzymatic activity of papain on a papain substrate releases a dye producing a detectable signal. The test device may be used in detecting compounds containing a free sulfhydryl group in industrial, environmental, experimental and biological samples. | 2010-01-28 |
20100022019 | METHOD OF MONITORING ADSORBENT BED BREAKTHROUGH IN A PROCESS FOR PRODUCING ALKYL ESTERS FROM VEGETABLE OR ANIMAL OIL AND FROM AN ALIPHATIC MONOALCOHOL - A method of monitoring breakthrough of an adsorbent bed consisting for example of ion-exchange resins, used during a stage of purification of an ester stream containing glycerin, obtained for example in a vegetable or animal oil and aliphatic monoalcohol transesterification process, permits the instantaneous detection of the presence of glycerol (glycerin) in the ester stream by arranging a turbidimeter at the adsorbent bed outlet. | 2010-01-28 |
20100022020 | Compositions for surface enhanced infrared absorption spectra and methods of using same - A composition comprising a substrate and at least one adsorbate associated with the substrate wherein the composition has an enhanced infrared absorption spectra. A method comprising tuning a nanoparticle to display a plasmon resonance in the infrared, associating an adsorbate with the nanoparticle to form an adsorbate associated nanoparticle, and aggregating the adsorbate associated nanoparticle. A method of preparing a SERS-SEIRA composition comprising fabricating a nanoparticle substrate, functionalizing the nanoparticle substrate to form a functionalized substrate, dispersing the functionalized substrate in solution to form a dispersed functionalized substrate, and associating the dispersed functionalized substrate with a medium. | 2010-01-28 |
20100022021 | NEW AZIDE SUBSTITUTED NAPHTHYLENE OR RYLENE IMIDE DERIVATIVES AND THEIR USE AS REAGENTS IN CLICK-REACTIONS - Novel mono-azide substituted rylene-imide derivatives, their use in methods for the detection of analytes and reagents kits for the detection of analytes comprising said novel mono-azide substituted rylene-imide derivatives. | 2010-01-28 |
20100022022 | FLUOROGENIC HOMOGENEOUS BINDING ASSAY METHODS AND COMPOSITIONS - Disclosed are binding substrate compositions, methods and kits useful for, among other things, detecting and/or characterizing binding interactions between molecules of interest. | 2010-01-28 |
20100022023 | Pressure activatable chemiluminescent system useful for covert intrusion detection - This invention is directed towards chemiluminescent systems useful in the practice of methods of intrusion detection, compositions useful for intrusion detection and methods for their formation, and to covert intrusion detection techniques and compositions therefore containing an infrared light generating chemiluminescent system, blended into an earthen-like carrier that enable one to detect whether any movement has breached an area during a certain time frame. | 2010-01-28 |
20100022024 | Method for testing performance of reagents containing microparticles - The present invention provides: a method of testing the performance of reagents containing microparticles by mixing a standard specimen containing two or more kinds of ligands with two or more kinds of microparticles containing receptors capable of specifically binding to the respective ligands and being optically distinguishable, and detecting the optical characteristics of the aggregates thus formed; a kit for detecting a specimen provided with the standard specimen and the microparticles as described above; a method of quantifying a specimen after testing the performance of reagents containing microparticles as described above, mixing a specimen containing two or more kinds of ligands capable of specifically binding to the respective receptors in the microparticles with the microparticles, detecting the optical characteristics of the aggregates thus formed, and then repeating the testing performance of reagents containing microparticles. Thus the present invention provides a performance test of reagents containing microparticles which is suitable for detecting a biological specimen such as a nucleic acid, a quantification method of a specimen which uses the performance testing method thereof and a specimen detection kit including the reagent. | 2010-01-28 |
20100022025 | METHOD OF DETECTING HUMAN BETA-DEFENSINS - A method of detecting β-defensin in a bodily sample from a subject includes reducing the electrostatic interaction between β-defensin and negatively charged moieties in the bodily sample prior to detecting the β-defensin with an antibody or epitope binding fragment thereof. | 2010-01-28 |
20100022026 | METHODS, KITS, REAGENTS AND DEVICES FOR DETECTING MESOTHELIN AND/OR MEGAKARYOCYTE POTENTIATING FACTOR IN PERITONEAL FLUIDS - Certain embodiments disclosed herein are directed to methods and kits for detecting and quantifying in patient peritoneal fluid, such as spent peritoneal dialysis buffer, peptides having amino acid sequences related to megakaryocyte potentiating factor. The methods and kits can be used to monitor the biological status of the mesothelial lining of the peritoneal cavity in a patient, to predict development of a pathology of the mesothelium in an otherwise asymptomatic patient, and/or to assess the risk and suitability of a therapeutic method. In particular, the method can be used to assess negative effects of peritoneal dialysis on the biological integrity of the peritoneum, and thus to determine the time point when peritoneal dialysis treatment should be discontinued in favor of hemodialysis in a patient with kidney dysfunction, in order to avoid the development of peritoneal hypertrophy and other progressive mesothelial disorders such as encapsulating peritoneal sclerosis. | 2010-01-28 |
20100022027 | GENE 763 OF PHYTOPATHOGENIC FUNGUS MAGNAPORTHE GRISEA AND USE THEREOF FOR IDENTIFYING FUNGICIDAL COMPOUNDS - The invention concerns a novel nucleic acid fragment of the genome of rice pathogenic fungus | 2010-01-28 |
20100022028 | HUMAN OX2 RECEPTORS - Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors or agonists thereof. | 2010-01-28 |
20100022029 | HOMOCYSTEINE IMMUNOASSAY - In immunoassays such as homocysteine immunoassays, it is known that the measured values can be dispersed due to the influence of inhibiting substances present in a biological sample on the immunoreaction. The present invention provides among other things a method whereby the influence of the immunoreaction inhibiting substances is easily and efficiently suppressed or eliminated, and also provides a kit used for such a method. The influence of the immunoreaction inhibiting substances is suppressed or eliminated when the analyte (e.g., homocysteine) contained in the biological sample is reacted with the antibody in the presence of extrinsic polyanion. | 2010-01-28 |
20100022030 | DRY ETCH STOP PROCESS FOR ELIMINATING ELECTRICAL SHORTING IN MRAM DEVICE STRUCTURES - The present invention relates generally to semiconductor fabrication and particularly to fabricating magnetic tunnel junction devices. In particular, this invention relates to a method for using the dielectric layer in tunnel junctions as an etch stop layer to eliminate electrical shorting that can result from the patterning process. | 2010-01-28 |
20100022031 | SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURING THE SAME - Provided is a semiconductor device, including a silicon substrate, a first insulating film formed on the silicon substrate, a first conductive plug formed in an inside of a first contact hole of the first insulating film, an underlying conductive film having a flat surface formed on the first conductive plug and in the circumference thereof, a crystalline conductive film formed on the underlying conductive film, and a capacitor in which a lower electrode, a dielectric film made of a ferroelectric material, and an upper electrode are laminated in this order on the crystalline conductive film. | 2010-01-28 |
20100022032 | METHOD OF FORMING ORGANIC FERROELECTRIC FILM, METHOD OF MANUFACTURING MEMORY ELEMENT, MEMORY DEVICE, AND ELECTRONIC APPARATUS - A method of forming an organic ferroelectric film configured to include an organic ferroelectric material with a crystalline property as a principal material includes (a) forming a low crystallinity film having a crystallinity lower than a crystallinity of the organic ferroelectric film on one surface of a substrate, and (b) forming the organic ferroelectric film from the low crystallinity film. The step (a) includes applying a liquid material containing the organic ferroelectric material on the one surface of the substrate and then drying the liquid material, and the step (b) includes heating and pressurizing the low crystallinity film to enhancing the crystallinity in the low crystallinity film while fairing the low crystallinity film. | 2010-01-28 |