04th week of 2016 patent applcation highlights part 39 |
Patent application number | Title | Published |
20160025621 | SYSTEMS AND METHODS FOR PANEL DESIGN IN FLOW CYTOMETRY - Embodiments of the present invention encompass systems and methods for determining detection limits for various antibody-dye conjugates for flow cytometry. Exemplary techniques involve a linear superpositioning approach of spillover-induced enlargements of normally distributed measurement errors. | 2016-01-28 |
20160025622 | SENSING SYSTEMS AND METHODS USING A COUPLING STRUCTURE - A sensor system having coupling structures is disclosed. The system includes an input coupling structure, an interaction region, and an output coupling structure. The input coupling structure is configured to receive emitted light at a selected coupling efficiency and may provide filtering of the emitted light for a selected wavelength. The interaction region is coupled to the input coupling structure and configured to interact the light from the input coupling structure with a specimen. The output coupling structure is coupled to the interaction region and configured to provide interacted light from the interaction region to the detector. | 2016-01-28 |
20160025623 | METHOD FOR DETERMINING A PROPERTY OF A HETEROGENEOUS MEDIUM - A method of determining a property of a heterogeneous medium in motion comprising at least two phases is provided. A light beam is made small in relation to a part of the medium for which a property is to be determined and the bandwidth of the measurement signal is sufficiently high for distinguishing time periods for the measurement signal which are related to the part of the medium for which a property is to be determined. By using the measurement signal for determining the property of the part of the medium for which a property is to be determined for time periods for the measurement signal which are related to that part of the medium, and determining the property by a mathematical calculation using the measurement signal corresponding to that part of the medium, the properties of individual parts of the medium can be determined. | 2016-01-28 |
20160025624 | MOBILE SMART DEVICE INFRARED LIGHT MEASURING APPARATUS, PIMETHOD, AND SYSTEM FOR ANALYZING SUBSTANCES - A handheld infrared spectroscopy device and method of use. The device is a hand-held spectroscopy device, that may be integral to a mobile phone or smart device such as a smart phone, tablet, personal digital assistant, computer or other device that is portable and capable of performing applications. A liquid sample port internal to the device and in close proximity to the device spectrometer performs infrared spectra analysis on liquid samples, allowing both portability as well as highly sophisticated and specific spectral analysis of liquid samples. The device has wireless communication capability, enabling transmission of data and spectral imagery across the globe. | 2016-01-28 |
20160025625 | METAMATERIAL SENSOR PLATFORMS FOR TERAHERTZ DNA SENSING - A sensor platform is provided for interrogating a sample with an electromagnetic (EM) wave. The platform includes: a dielectric material having opposing first and second planar surfaces; a first array of loop elements embedded in the first planar surface of the dielectric material, wherein slots are formed between the loop elements in the first array of loop elements and configured to host a sample material therein; and a second array of loop elements embedded in the second planar surface of the dielectric material and formed symmetrically with respect to the first array of loop elements, wherein slots are also formed between the loop elements of the second array of loop elements. The loop elements in the first array and the second array are comprised of a conductive material. | 2016-01-28 |
20160025626 | SILICON PHOTONIC CRYSTAL NANOBEAM CAVITY WITHOUT SURFACE CLADDING AND INTEGRATED WITH MICRO-HEATER FOR SENSING APPLICATIONS - A silicon photonic crystal nanobeam cavity device is described, including a heater that can set a desired temperature on the cavity device in order to control its resonant wavelength. The device has no cladding, which is advantageous for sensing. Biosensing applications with temperature control can be carried out with the nanobeam cavity device. | 2016-01-28 |
20160025627 | METHOD AND DEVICE FOR DETERMINING A VISUAL RANGE IN DAYTIME FOG - A method is provided for determining a visual range in daytime fog, the method ( | 2016-01-28 |
20160025628 | MOBILE DEVICE WHICH SENSES PARTICULATE MATTER AND METHOD OF SENSING PARTICULATE MATTER WITH THE MOBILE DEVICE - A mobile device which senses particulate matter is provided. The mobile device includes a housing having an air flow path through which air flows when the mobile device is shaken; an inertia sensor that detects acceleration of the mobile device; a light-scattering type sensor that irradiates the air flow path with light and detects particulate matter in air flowing through the air flow path; and a controller that includes a counter for counting the particulate matter detected by the light-scattering type sensor, and a flow rate calculator for detecting an air flow rate of the air flow path based on a detection signal of the inertia sensor. | 2016-01-28 |
20160025629 | METHOD FOR DETERMINING THE SURFACE GLOSS OF A COLOUR STANDARD - The invention relates to a method for determining the gloss of a colour standard comprising the following steps:
| 2016-01-28 |
20160025630 | ANALYTICAL INSTRUMENT SYSTEMS - The invention provides optical instrument systems and methods for analyzing signals from biological arrays, and performing analytical amplification reactions for identifying the presence or absence of a target nucleic acid sequence in a sample to be analyzed. | 2016-01-28 |
20160025631 | FABRICATION OF A FLUORESCENT MATERIAL FOR SENSING AN ANALYTE - An analyte indicator may include a porous base and may be included in an analyte sensor. The analyte indicator may retain its physical, chemical, and optical properties in the presence of compression. The porous base may not vary in opacity. The analyte indicator may include (i) a polymer unit attached or polymerized onto or out of the porous base and (ii) an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit. The analyte sensing element may include one or more indicator molecule. The analyte sensing element may include one or more indicator polymer chains. The analyte indicator may include (i) an indicator polymer chain attached or polymerized onto or out of the porous base and (ii) indicator molecules attached to the indicator polymer chain. | 2016-01-28 |
20160025632 | METHODS AND SYSTEMS FOR SPATIALLY IDENTIFYING ABNORMAL CELLS - The present invention provides compositions and methods for imaging tumor resections. | 2016-01-28 |
20160025633 | USE OF RAMAN SPECTROSCOPY TO MONITOR CULTURE MEDIUM - In one aspect, the disclosure provides a method of defining a Raman signature of a culture component, the method comprising: obtaining a Raman spectrum of a culture component in a non-interfering or minimally-interfering solution, identifying peaks in the Raman spectrum that are associated with the culture component, obtaining a Raman spectrum of a culture medium comprising the culture component, and, removing peaks of the culture component in the Raman spectrum of the culture medium that are distorted compared to the peaks identified in the Raman spectrum of the culture component in a non-interfering or minimally-interfering solution. | 2016-01-28 |
20160025634 | Composite Nanoparticle Structures for Chemical and Biological Sensing - Described herein is a nanoparticle that enhances the interaction of the nanoparticle and/or a molecule/material deposited on the surface of the nanoparticle with light, comprising a pair of stacked metallic disks separated by a non-metallic spacer, wherein: (a) the dimensions of the disks and spacer are smaller than the wavelength of the light; and (b) the nanoparticle enhance the light interaction at least three times greater than that an individual metallic disk. Methods for making the nanoparticle and methods for using the nanoparticle in a variety of assays are also provided. | 2016-01-28 |
20160025635 | DEVICES TO DETECT A SUBSTANCE AND METHODS OF PRODUCING SUCH A DEVICE - Devices to detect a substance and methods of producing such a device are disclosed. An example device to detect a substance includes a housing defining a first chamber and a substrate coupled to the housing. The substrate includes nanostructures positioned within the first chamber. The nanostructures are to react to the substance when exposed thereto. The device includes a first heater positioned within the first chamber. The heater is to heat at least a portion of the substance to ready the device for analysis. | 2016-01-28 |
20160025636 | SUBSTRATES, DEVICES, AND METHODS FOR QUANTITATIVE LIQUID CRYSTAL ASSAYS - The present invention relates to the field of molecular diagnostics, and in particular to diagnostics based on a liquid crystal assay format. In particular, the present invention provided improved substrates and methods of using liquid crystal assays for quantitating the amount of an analyte in a sample. The present invention also provides materials and methods for detecting non-specific binding of an analyte to a substrate by using a liquid crystal assay format. | 2016-01-28 |
20160025637 | MICROWELL ARRAY ARTICLES AND METHODS OF USE - The disclosure provides microstructured articles and methods useful for detecting an analyte in a sample. The articles include microwell arrays. The articles can be used with an optical system component in methods to detect or characterize an analyte. | 2016-01-28 |
20160025638 | TEST STRIP METER WITH A MECHANISM FOR PUSHING THE TEST STRIP AGAINST AN OPTICAL READER - The present invention relates to a system, method, and meter for determining the concentration of an analyte in a fluid sample provided on a test strip. The meter ( | 2016-01-28 |
20160025639 | POINT OF CARE ANALYTICAL PROCESSING SYSTEM - A point of care testing system includes a reader having an incubator disposed within a reader housing, the incubator having a rotor supported for rotation and having a plurality of circumferentially disposed slots. A drive mechanism is configured to rotate the rotor about a center axis A plurality of analytical test elements are sized for fitting in the slots of the incubator either manually or on demand. Each analytical test element commonly includes a support within a cartridge. The support retains at least one of a dry chemistry chip comprising a porous spreading layer disposed in stacked relation with at least one reagent layer or a lateral flow assay device wherein the plurality of test elements can assume a common form factor with multiplexed capability, and in which cartridges are preferably gated to enable random access processing. | 2016-01-28 |
20160025640 | PORTABLE ELECTRONIC ASSAY DEVICE, PORTABLE ASSAY DEVICE AND KIT THEREOF - The present invention is related to a portable electronic assay device, a portable assay device and a kit thereof. The portable electronic assay device is used for determining a result of an assay performed using a test strip comprises a casing, an optical module, a light detector, and a processor. The casing comprises a transmissive part. The optical module emits a detecting light signal and display light signal. The detecting light signal is illuminated to the test strip and the display light signal is illuminated to the transmissive part. The light detector detects light from the test strip so as to obtain a detecting signal. The processor receives the detecting signal compared with a default value so as to obtain an assay result. The assay result is displayed on the transmissive part. Therefore, it provides simple structure of the assay device for displaying the assay result rapidly and correctly. | 2016-01-28 |
20160025641 | DRIP CHAMBER WITH INTEGRATED OPTICS - A drip chamber for an infusion tube that includes a first end arranged to receive a drip tube, a second end including an exit port, at least one wall connecting the first and second ends, a space enclosed by the first and second ends and the at least one wall, and first and second lenses each directly fixed to said at least one wall. | 2016-01-28 |
20160025642 | METHOD AND APPARATUS FOR AUTOMATIC MEASUREMENT OF VARIOUS QUALITIES OF PRINTED SHEETS - Embodiments of the invention relate to the automatic measuring of such qualities of a printed sheet as reflectance excluding specular reflectance, reflectance including specular reflectance, e.g. gloss, transmittance, half-tone coverage, and the like. | 2016-01-28 |
20160025643 | GEMSTONE REGISTRATION SYSTEM - A device for producing a reproducible identification pattern of a polished gemstone includes light directing means for directing a focused beam of light onto a gemstone orientated in a particular known manner to produce an output of the internal refraction and reflection characteristics of the gemstone including reflected light beams having particular locations, sizes and intensities. The device also includes automated means for changing a position of the gemstone relative to the focused beam of light; and also a means for recording the output in a manner to record the relative size and location of the reflected light beams. | 2016-01-28 |
20160025644 | METHOD AND SYSTEM FOR OPTICALLY INSPECTING A MANUFACTURED PART AT A SINGLE INSPECTION STATION HAVING A MEASUREMENT AXIS - A method and system for optically inspecting a manufactured part at a single inspection station having a measurement axis are provided. The system comprises a fixture assembly which includes a rotatable first fixturing component to support a part in a generally vertical orientation and a rotatable second fixturing component mating with and removably connected to the first fixturing component to transmit torque from the first fixturing component to the second fixturing component. The second fixturing component includes a device for holding the part in a generally horizontal orientation and to permit rotation of the horizontally held part about the measurement axis between first and second predetermined angular positions about the axis. The system also comprises an actuator assembly, a backside illumination assembly, a frontside illumination device, a lens and detector assembly and at least one processor to process electrical signals generated by the lens and detector assembly. | 2016-01-28 |
20160025645 | System and Method for Simultaneous Dark Field and Phase Contrast Inspection - An inspection apparatus for simultaneous dark field (DF) and differential interference contrast (DIC) inspection includes an illumination source and a sample stage configured to secure a sample. The inspection apparatus includes a first sensor, a second sensor and an optical sub-system. The optical sub-system includes an objective, one or more optical elements arranged to direct, through the objective, illumination from the one or more illumination sources to a surface of the sample. The objective is configured to collect a signal from the surface of the sample, wherein the collected signal includes a scattering-based signal and/or a phase-based signal from the sample. The inspection apparatus includes one or more separation optical elements arranged to spatially separate the collected signal into a DF signal and a DIC signal by directing the DF signal and the DIC signal along a DF path and DIC path respectively. | 2016-01-28 |
20160025646 | COMPRESSIVE SENSING WITH ILLUMINATION PATTERNING - Methods and systems are provided, which pattern an illumination of a metrology target with respect to spectral ranges and/or polarizations, illuminate a metrology target by the patterned illumination, and measure radiation scattered from the target by directing, at a pupil plane, selected pupil plane pixels from a to respective single detector(s) by applying a collection pattern to the pupil plane pixels. Single detector measurements (compressive sensing) has increased light sensitivity which is utilized to pattern the illumination and further enhance the information content of detected scattered radiation with respect to predefined metrology parameters. | 2016-01-28 |
20160025647 | METHOD FOR DETECTING AND/OR PREVENTING GRIND BURN - The present disclosure provides a method of detecting and preventing grind burn from developing on a gear. The method includes performing acoustic emission testing while the gear is being ground during a grinding operation. The grinding wheel is evaluated during an eddy current test to detect material buildup on the grinding wheel which could cause grind burn. In addition, the method includes collecting swarf from the gear during the grinding operation and inspecting the swarf for an indication of grind burn. | 2016-01-28 |
20160025648 | Virtual Inspection Systems with Multiple Modes - Methods and systems for determining one or more characteristics for defects detected on a specimen are provided. One system includes one or more computer subsystems configured for identifying a first defect that was detected on a specimen by an inspection system with a first mode but was not detected with one or more other modes. The computer subsystem(s) are also configured for acquiring, from the storage medium, one or more images generated with the one or more other modes at a location on the specimen corresponding to the first defect. In addition, the computer subsystem(s) are configured for determining one or more characteristics of the acquired one or more images and determining one or more characteristics of the first defect based on the one or more characteristics of the acquired one or more images. | 2016-01-28 |
20160025649 | METHOD OF INSPECTING FOREIGN SUBSTANCE ON SUBSTRATE - In order to inspect a substrate, an image information of a substrate before applying solder is displayed. Then, at least one inspection region on the substrate is image-captured to obtain an image of the inspection region that is image-captured. Then, image information that is to be displayed is renewed and the renewed image information is displayed. And, in order to inspect a foreign substance, obtained image of the inspection region is compared with a reference image of the substrate. Therefore, an operator can easily catch a region corresponding to a specific region of the image that is displayed, and easily detect a foreign substance on the substrate. | 2016-01-28 |
20160025650 | OVERLAY METROLOGY METHOD AND OVERLAY CONTROL METHOD AND SYSTEM - The present disclosure provides an overlay metrology method, an overlay control method and an overlay control system. The overlay metrology method includes capturing a current layer image of a current overlay mark on a current layer with a current focal length and capturing a previous layer image of a previous overlay mark on a previous layer with a previous focal length. Then, the overlay metrology method further includes combining the current layer image with the previous layer image to form an overlay mark image and determining an overlay error between the current overlay mark and the previous overlay mark based on the overlay mark image. | 2016-01-28 |
20160025651 | LIGHTING DOMES - A lighting dome that can be used to inspect semiconductor wafers can include a small aperture, backlighting, a reflectance gradient and/or a broad spectrum light source. | 2016-01-28 |
20160025652 | APPARATUS AND SYSTEM FOR PEST DETECTION, AND METHOD FOR DETECTING PEST DAMAGE - Provided are apparatus and system for pest detection and a method for detecting pest damage to prevent pest damage in wooden building structures. The apparatus according to one aspect of the present invention comprises: a post-shaped main body extending in a set direction and formed therealong, and comprising a plurality of holes distanced from each other with a wall therebetween, the wall comprising timber which can be despoiled by pest; and a sensor unit allowing attachment and detachment to and from the upper end of the main body. Here, the sensor unit may comprise: a light-emitting unit comprising at least one light-emitting body for irradiating the interior of at least one hole among the plurality of holes; a sensing unit for sensing the light, emitted from the light-emitting unit, in the interior of at least one hole from among the plurality of holes; and a detection unit for outputting a light signal received from the sensing unit as an electrical signal. | 2016-01-28 |
20160025653 | BORESCOPE APPARATUS AND A METHOD OF USING SAME - The present invention relates generally to a borescope or an inspection, scope apparatus and a method of using sane. More particularly, the invention encompasses a borescope having a hollow rigid insertion tube that is mated with a main control unit, or main body. The hollow insertion tube has at least one image sensor, and at least one LED or light source at the distal end of the probing tube to provide image and other information to the main control unit or main body. An opening is made in the wall of the structure to be inspected, and the hollow rigid probe is inserted, and with the light source activated, images within the structure cavity are obtained. After the internal inspection of the cavity has been completed, the probe is extracted, and the hole is closed. The invention also provides a method of using the inventive borescope apparatus. | 2016-01-28 |
20160025654 | APPARATUS AND METHOD FOR INSPECTION OF SUBSTRATE DEFECT - Example embodiments relate to an apparatus and method for inspecting a substrate defect. The substrate defect inspecting apparatus includes a substrate, a light source emitting an infrared beam to the substrate, a detector detecting the infrared beam reflected from the substrate, and a defect analyzer receiving first information and second information from the detector and analyzing defects existing in the substrate. According to at least one example embodiment, the second information is acquired during a later process than the first information. | 2016-01-28 |
20160025655 | Radio-Frequency Nanopore Sensor - An electrically conductive nanoscale pore may be employed as an antenna to provide precise localized measurements of the impedance-altering characteristics of a molecule such as DNA or RNA or the like passing through the pore. The use of radiofrequency measurements promises high-speed analysis of long molecules (polymers). | 2016-01-28 |
20160025656 | Microwave Plasma Spectrometer Using Dielectric Resonator - A dielectric resonator is excited at its natural resonant frequency to produce a highly uniform electric field for the generation of plasma. The plasma may be used as a desolvator, atomizer excitation source and ionization source in an optical spectrometer or a mass spectrometer. | 2016-01-28 |
20160025657 | Methods and Systems for Non-Destructive Analysis of Objects and Production of Replica Objects - In one aspect, the present disclosure provides a method including rotating a rotatable surface with an object positioned thereon to a plurality of angular positions. The method also includes capturing, via an x-ray microtomography device at each of the plurality of angular positions, a tomograph of the object. The method also includes summing each tomograph of the object to create a three-dimensional image of the object. The method also includes using an additive manufacturing machine to create a three-dimensional replica of the object using the three-dimensional image of the object. | 2016-01-28 |
20160025658 | VISIBLE X-RAY INDICATION AND DETECTION SYSTEM FOR X-RAY BACKSCATTER APPLICATIONS - An X-ray backscatter indication and detection system, including an object disposed with respect to a target area targeted by X-rays, such that X-rays that backscatter from the target area strike the surface of the object. The surface of the object includes an X-ray sensitive indicator substance that fluoresces with a visible light when contacted by backscattered X-rays. | 2016-01-28 |
20160025659 | Charged Particle Beam Device, Sample Observation Method, Sample Platform, Observation System, and Light Emitting Member - The purpose of the present invention is to eliminate the effort in placement and extraction of samples in observations using transmitted charged particles. A charged particle beam device ( | 2016-01-28 |
20160025660 | Thermal flow sensor for determining a gas or the composition of a gas mixture as well as its flow velocity - A thermal flow sensor for determining a gas or the composition of a gas mixture as well as its flow velocity, comprising: a substrate onto which at least a first dielectric layer is applied; at least one heating structure that is applied onto the first dielectric layer and serves to heat the gas or the gas mixture; at least a first temperature sensor element that is applied onto the first dielectric layer at a distance from the heating structure and captures the temperature of the gas or gas mixture heated at the heating structure; a control device that controls the heating structure in a first operating mode in such a way that the heating structure shows a predetermined temperature, and controls the heating structure in a second operating mode in such a way that a power input into the heating structure corresponds to a predetermined power; and an evaluation unit which determines at least one physical characteristic of the gas present or the gas mixture on the basis of the operating modes and determines the gas present or the composition of the gas mixture as well as its flow velocity on the basis of this physical characteristic. | 2016-01-28 |
20160025661 | FLOW-MEASURING DIFFERENTIAL CALORIMETER - A differential calorimeter with flux measurement to measure a heat flux emitted by radioactive materials contained in a container, including: a measurement cell including measurement plates distributed around a container reception containment; and a reference cell including reference plates and a reference sample. The reference plates are placed behind the measurement plates from the container when the container is in the reception containment and the reference sample is under the reception containment. | 2016-01-28 |
20160025662 | SYSTEMS AND METHODS OF MONITORING A THERMAL PROTECTION SYSTEM - A method of monitoring a thermal protection system coupled to a structural component is provided. The thermal protection system includes a thermally insulative body and at least one layer of thermochromatic material applied thereon such that the at least one layer is positioned between the thermally insulative body and the structural component. The method includes determining a value of a thermochromatic property of the at least one layer of thermochromatic material, wherein the value of the thermochromatic property is responsive to an amount of heat applied to the at least one layer of thermochromatic material, comparing the value to a baseline value of the thermochromatic property, and determining degradation of the thermal protection system when the value of the thermochromatic property deviates from the baseline value. | 2016-01-28 |
20160025663 | METHOD AND APPARATUS FOR INVESTIGATING PERMITTIVITY IN A TARGET DOMAIN - A method for investigating permittivity within a target domain comprises a step of measuring, for a plurality of pairs of contact element groups, the contact elements of the contact element groups being arranged in capacitance measurement connection with the target domain, an electrical quantity of interest proportional to the capacitance of a capacitor formed by a pair of contact element groups; the contact elements comprising a plurality of electrodes supported between the target domain and an electrically conductive background body limiting the capacitance measurement zone of the electrodes. The contact elements may further comprise the electrically conductive background body. | 2016-01-28 |
20160025664 | Trapped Sacrificial Structures And Methods Of Manufacturing Same Using Thin-Film Encapsulation - Trapped sacrificial structures and thin-film encapsulation methods that may be implemented to manufacture trapped sacrificial structures such as relative humidity sensor structures, and spacer structures that protect adjacent semiconductor structures extending above a semiconductor die substrate from being contacted by a molding tool or other semiconductor processing tool in an area of a die substrate adjacent the spacer structures. | 2016-01-28 |
20160025665 | HUMIDITY SENSOR WITH VOID WITHIN INTERCONNECT AND METHOD OF MANUFACTURING THE SAME - A humidity sensor and a method of manufacturing the same are provided where voids are formed within interconnects configured to facilitate the operation of the device and a humidity sensing material is deposited within the voids to detect the humidity. The accuracy with respect to the measurement of the humidity sensor is improved and manufacturing costs are lowered. The humidity sensor includes a substrate, a first interlayer insulating layer disposed on the substrate, first and second metal electrodes disposed adjacent to each other on the first interlayer insulating layer, an etch stop layer covering the first interlayer insulating layer and the first and second metal electrodes, a second interlayer insulating layer disposed on the first etch stop layer, voids formed within the second interlayer insulating layer, and a humidity sensing material deposited in the voids. | 2016-01-28 |
20160025666 | ELECTRIC FIELD SENSOR - According to embodiments, an electric field sensor having a sensor electrode is constructed of an electrically conductive material and having one or more outwardly protruding pillars. A screen electrode overlies the sensor electrode and has one or more openings which register with the one or more pillars on the sensor electrode. At least one piezoelectric actuator is connected to the screen electrode so that, when excited by a voltage signal, the piezoelectric actuator modulates the screen electrode toward and away from the sensor electrode at the frequency of the periodic voltage signal. An output circuit configured to detect a voltage, a current output, or both, between the sensor electrode and the screen electrode which is proportional in magnitude to the strength of the electric field. | 2016-01-28 |
20160025667 | APPARATUS FOR THE DETECTION OF LIQUIDS OR SUBSTANCES FROM LIQUIDS - An apparatus for detecting liquids or substances from liquids in spatially separate reaction zones using a plug-in module or a chip card for rapid immunological tests, for example, with the help of a reading device. The liquids or substances from liquids are detected by a sensor array and on which at least one diaphragm is arranged. Individual sensors are spatially separated from each other on a plane by means of walls. The diaphragm is filled with liquid that is to be analyzed. Sealed reaction chambers are created when pressure is applied to the diaphragm. Pores in the diaphragm are completely closed in the zone of the walls while the pores are merely reduced in size and liquid can continue to be exchanged in zones directly above the sensors. No liquid can be exchanged between adjacent reaction chambers as long as pressure is applied to and compresses the diaphragm. | 2016-01-28 |
20160025668 | INSTRUMENTED PACKETS FOR TESTING CHARGE STORAGE DEVICES - A sachet includes a first wing made of a flexible material and having a first perimeter region circumscribing a first central region; a second wing made of the flexible material; a hinge connecting the first and second wings along a common boundary; an adhesive material applied to the perimeter region on the first wing; a first electrically conducting electrode formed on the first wing within the central region of the perimeter region; a second electrically conducting electrode formed on the second wing in a region that is opposed to and in alignment with the first contact area on the first wing; an array of contact pads formed on at least one of the first and second wings; first and second conducting traces electrically connecting first and second groups of one or more contact pads among the array of contact pads to the first and second electrodes, respectively. | 2016-01-28 |
20160025669 | STRETCHABLE IONICS FOR TRANSPARENT SENSORS AND ACTUATORS - A class of devices enabled by ionic conductors is highly stretchable, fully transparent to light of all colors, biocompatible or biodegradable, and capable of operation at frequencies beyond 10 kilohertz and voltages above 10 kilovolts. These devices enabled by ionic conductors can be used as large strain actuators, full-range loudspeakers, as strain or pressure sensors and as stretchable interconnects. The electromechanical transduction is achieved without electrochemical reaction. When large stretchability and high optical transmittance are required, the ionic conductors have lower sheet resistance than all existing electronic conductors. | 2016-01-28 |
20160025670 | IMPROVEMENTS RELATING TO TEST DEVICES - The invention relates to test devices such as diagnostic test devices. In particular the invention relates to individually packaged test devices. The invention also relates to methods of manufacturing such individually packaged test devices, use of such individually packaged test devices, and test device cards comprising two or more test devices. In particular, the invention relates to a test device comprising: a test strip having first and second major surfaces and comprising: a proximal portion for bearing contacts for a metering device, an intermediate portion for receiving a sample comprising a test area on the first major surface, the test area comprising at least one test component; a separable distal portion; and in which the test device further comprises: a cover leaf (optionally a removable cover leaf) having a portion (optionally a removable portion) extending over at least part of one of the major surfaces of the test strip so as to seal the test area and having a non-removable portion attached to the separable distal portion of the test strip. | 2016-01-28 |
20160025671 | METHODS FOR GENERATING pH/IONIC CONCENTRATION GRADIENT NEAR ELECTRODE SURFACES FOR MODULATING BIOMOLECULAR INTERACTIONS - Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample. | 2016-01-28 |
20160025672 | ELECTRONIC DEVICE FOR MEASURING BLOOD SUGAR - An operating method of an electronic device may include detecting that a strap with a blood sugar measuring device has been connected to the electronic device, receiving blood sugar related data from the blood sugar measuring device, and executing a health application based on the received data. | 2016-01-28 |
20160025673 | System Error Compensation Of Analyte Concentration Determinations - During analyte analysis, errors may be introduced into an analysis by both the biosensor system used to perform the analysis and by errors in the output signal measured by the measurement device of the biosensor. For a reference sample, system error may be determined through the determination of relative error. However, during an analysis of a test sample with the measurement device of the biosensor system, true relative error cannot be known. A pseudo-reference concentration determined during the analysis may be used as a substitute for true relative error. The present invention introduces the determination of a pseudo-reference concentration determined during the analysis as a substitute for the true relative error and uses an anchor parameter to compensate for the system error in the analysis-determined pseudo-reference concentration. | 2016-01-28 |
20160025674 | LIQUID SAMPLE MEASUREMENT DEVICE, LIQUID SAMPLE MEASUREMENT METHOD, AND BIOSENSOR - It is intended to provide, for example, a liquid sample measurement device capable of measuring the amounts of components of a liquid with a high accuracy. A first voltage is applied to an electrode pair | 2016-01-28 |
20160025675 | METHOD FOR ELECTRONIC BIOLOGICAL SAMPLE ANALYSIS - A biological sample analysis device includes a casing that encloses a biological sample delivery system hydraulically coupled to a sensor, wherein the sensor includes a plurality of Graphene transistors and each transistor covalently bonds with a biomarker causing the electrical properties of the transistor to measurably change when the biomarker is exposed to corresponding antibodies within an infected biological sample. | 2016-01-28 |
20160025676 | COMPOSITIONS AND METHODS FOR IMPROVING RESOLUTION OF BIOMOLECULES SEPARATED ON POLYACRYLAMIDE GELS - Gels, such as polyacrylamide gels, are provided that include linear polyacrylamide in the stacking gel. Native gels that include linear polyacrylamide in the stacker can be used to separate biomolecular complexes, such as protein complexes. Gel cassettes in which the gap width between front and back plates does not vary by more than 5% at the upper edge of the cassette are also provided. The gel cassettes can be used for electrophoretic separation of proteins and protein complexes on native gels, such as native gels that include linear polyacrylamide in the stacker. The native gels can have multiple wells for electrophoresing at least one sample and/or at least one molecular weight standard. | 2016-01-28 |
20160025677 | PARTICLE CONCENTRATION SYSTEM - Methods and systems are provided for concentrating particles (e.g., bacteria, viruses, cells, and nucleic acids) suspended in a liquid. Electric-field-induced forces urge the particles towards a first electrode immersed in the liquid. When the particles are in close proximity to (e.g., in contact with) the first electrode, the electrode is withdrawn from the liquid and capillary forces formed between the withdrawing electrode and the surface of the liquid immobilize the particles on the electrode. Upon withdrawal of the electrode from the liquid, the portion of the electrode previously immersed in the liquid has particles immobilized on its surface. | 2016-01-28 |
20160025678 | Electrochemical Tongue - An electrochemical tongue can be used for detection of metal ions. The reference electrode of the electrochemical tongue can be coated with a polymer. More than one reference electrode can be used, and the electrochemical tongue can be inserted into a cone penetrometer for portable, in situ analysis. | 2016-01-28 |
20160025679 | INTERDIGITATED ELECTRODE CONFIGURATION FOR ION FILTER - An ion filter and a method of manufacturing an ion filter. The method including providing a monolithic structure; selectively removing regions of the structure, to form a pair of electrodes defining at least one ion channel therebetween. The electrodes are preferably mechanically connected at one or more locations by a portion of the structure; wherein the connecting portion of the structure provides a higher electrical impedance than the filter would provide without such a mechanical connection, to thereby electrically separate the electrodes. | 2016-01-28 |
20160025680 | NON-DESTRUCTIVE REAL-TIME MAGNETIC FLUX LEAKAGE IMAGING SYSTEM AND METHOD - A system and method for acquiring three-dimensional images of a magnetic flux leakage present in steel tendons, which are embedded in concrete and/or grout. The inventive method preferably magnetizes the steel tendon. Transducers detect the intensity of the magnetic field along the steel tendon. Using this magnetic intensity, three dimensional images of the magnetic flux leakage are generated using a data acquisition and computing device. Based on these images, a user can determine whether there is a fault, and what type of fault, in the steel tendon at that location, and therefore whether it should be investigated via a more intrusive procedure. The magnetic imaging device is capable of traversing the length of the tendon. As the invention moves along the tendon, images are generated. This allows the user to determine the location and source of a defect in real-time. | 2016-01-28 |
20160025681 | Pipeline Condition Detecting Method and Apparatus - The current invention relates to an apparatus for detecting at least one characteristic of a pipeline. The apparatus includes means for generating a magnetic flux along a portion of a pipeline wall, means for detecting the magnetic field, and at least one proximity sensor. The apparatus further includes means for generating an indication of whether defects are located in the internal or external wall of the pipeline. | 2016-01-28 |
20160025682 | FLEXIBLE EDDY CURRENT PROBE - A flexible eddy current probe and a method of use are provided. A flexible eddy current probe ( | 2016-01-28 |
20160025683 | MANAGING A SOUND SYSTEM - For managing a sound system, a method is disclosed that includes identifying a location for measuring sound, directing light from a light emitter to the location, determining a speckle pattern at the location based on data received from an optical interferometer, and adjusting a sound producer based on the determined speckle pattern. | 2016-01-28 |
20160025684 | DEVICE AND METHOD FOR NONDESTRUCTIVE INSPECTION OF TUBULAR PRODUCTS, ESPECIALLY ON SITE - A device for inspection of a tubular piece includes a cart including plural elemental ultrasound transducers distributed along at least a first direction and a guide which cooperates with an exterior surface of the piece to position the cart such that the first direction essentially corresponds to a direction transverse to the tubular piece. A control electronics, connected to the electroacoustic transducers, includes a memory storing the timed excitation laws and a controller that applies in succession a respective timed excitation law to subsets of mutually adjacent elemental transducers along the first direction. The timed excitation laws are designed so that the elemental transducers of the respective subsets jointly produce incident beams of ultrasonic waves propagating along respective directions inclined relative to a direction normal to the exterior surface of the tubular piece. | 2016-01-28 |
20160025685 | PHANTOM FOR CALIBRATING OBJECT INFORMATION ACQUIRING APPARATUS AND MANUFACTURING METHOD THEREOF - A phantom used for calibrating an object information acquiring apparatus that irradiates light into an object and acquires characteristic information inside the object based on an acoustic wave propagated from the object, the phantom comprises a base material; and a simulated tissue portion that simulates a three-dimensional structure of a tissue inside a living body, wherein the simulated tissue portion is disposed inside the base material, and has a simulated layer, which is a layer simulating optical characteristics of the tissue inside the living body, on the surface thereof. | 2016-01-28 |
20160025686 | METHOD AND SYSTEM OF CONSOLIDATING MULTIPLE PHASED ARRAY INSTRUMENTS - A non-destructive testing and inspection (NDT/NDI) system and method operable to conduct an ultrasonic scanning test on a test object that synchronizes and merges the apertures of two or more NDT sub-instruments in frequency and phase. Disclosed are a method of using a Phased Lock Loop (PLL) as a synchronizing clock/trigger generator, and also a method of using a General Positioning Clock (GPS) and a pulse per second (PPS) output. Both methods combine ultrasonic scanning data acquisition from two or more NDT sub-instruments, and transform the sub-instruments into one bigger NDT instrument. | 2016-01-28 |
20160025687 | NON-INVASIVE METHOD FOR MEASUREMENT OF PHYSICAL PROPERTIES OF FREE FLOWING MATERIALS IN VESSELS - Methods and apparatus for measuring physical properties of material in a vessel are provided. In one example, the method includes capturing a response to a vibration initiated by a source in mechanical communication with the vessel, generating a vibration response spectrum based on the response, and calculating at least one value of at least one physical property of the material based on at least one pre-established relationship between the at least one physical property and one or more characteristics of the vibration response spectrum. | 2016-01-28 |
20160025688 | Diaphragm Valve with Sealing Assembly, Chromatographic System Including Same and Method of Operation Thereof - A valve having a valve cap with a plurality of process conduits extending therethrough, each one of the plurality of process conduits ending in a process port at a valve cap interface. The valve also has a valve body defining a valve body interface facing the valve cap interface, a diaphragm positioned between the valve cap interface and the valve body interface, across the process ports, and a purge line provided through one of the valve cap and the valve body. The valve further comprises a sealing assembly located in the valve body. The sealing assembly is configured and positioned to block fluid leaked through the diaphragm such that the fluid leaked through the diaphragm is discharged via and exit of the purge line of the valve. A chromatographic system including the valve and a method of operation thereof are also provided. | 2016-01-28 |
20160025689 | SAMPLE INJECTOR WITH METERING DEVICE BALANCING PRESSURE DIFFERENCES IN AN INTERMEDIATE VALVE STATE - A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the sample injector comprising a switchable valve, a sample loop in fluid communication with the valve and configured for receiving the fluidic sample, a metering device in fluid communication with the sample loop and configured for introducing a metered amount of the fluidic sample on the sample loop, and a control unit configured for controlling switching of the valve to transfer the sample loop between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device during the intermediate state to at least partially equilibrate a pressure difference in the sample loop between the low pressure state and the high pressure state. | 2016-01-28 |
20160025690 | FLOW PATH SWITCHING VALVE - A stator and a rotor are in contact with each other while maintaining fluid tightness inside a housing including connection ports at an outer surface. The stator includes a port end portion arrangement surface that forms a part of an inner wall surface of the housing and where a plurality of holes that communicate with the connection ports are arranged. The rotor includes a flow path connection surface that is in contact with the port end portion arrangement surface of the stator while maintaining fluid tightness and to which a groove for selectively connecting the holes arranged at the port end portion arrangement surface is formed. At least one of the port end portion arrangement surface and the flow path connection surface is coated with a resin film having chemical resistance and slidability. | 2016-01-28 |
20160025691 | CHROMATOGRAPHY/MASS SPECTROMETRY DATA PROCESSING DEVICE - Using the intensity ratio of peaks on a standard mass spectrum of the target compound and peaks with the same m/z on the measured mass spectrum near the retention time of said compound, a scale factor waveform close to the chromatogram shape based on the target compound alone is computed, and m/z candidates for quantitation are extracted based on the correlation between the measured mass chromatogram of the target compound and the scale factor waveform. Furthermore, an intensity ratio is determined with reference to the m/z peaks showing the greatest scale factor on the measured mass spectrum at the measurement time point showing the greatest scale factor in the scale factor waveform, and m/z candidates for quantitation/confirmation are narrowed down based on whether they fall within an allowable range based on peak intensity ratio on the standard mass spectrum. | 2016-01-28 |
20160025692 | Analysis System - An analysis system is provided with: a storage unit that stores first information associating mass spectrometry result information with an analysis condition concerning ion mobility separation; and a control unit that determines, as a first analysis condition for an ion to be measured, the analysis condition associated with the mass spectrometry result information of the first information corresponding to the mass spectrometry result information of the ion to be measured. | 2016-01-28 |
20160025693 | METHOD FOR DETECTING CRYSTAL GRAIN BOUNDARIES OF GRAPHEME AND DEVICE USING METHOD - Provided are a method of detecting a grain boundary of graphene and a device using the same. | 2016-01-28 |
20160025694 | DEVICE FOR MEASURING THE THERMAL CONDUCTIVITY OF GAS COMPONENTS OF A GAS MIXTURE - A device for measuring thermal conductivity of gas components of a gas mixture in order to determine fractions of the gas components includes a plurality of thermal conductivity sensors, each thermal conductivity sensor being a component of a resistance bridge circuit and being connected to an evaluation unit associated with the device. Each thermal conductivity sensor has a heating element and an integrated temperature measuring element, which elements generate two measuring voltages (U | 2016-01-28 |
20160025695 | METHYLBENZENE GAS SENSOR USING CHROME-DOPED NICKEL OXIDE NANOSTRUCTURES AND METHOD FOR PRODUCING SAME - Provided is a gas sensor comprising a gas-sensitive layer consisting of nickel oxide (NiO) doped with chrome (Cr) so as to selectively detect methylbenzene gas. The gas sensor, according to the present invention, has a gas-sensitive layer consisting of Cr-doped NiO. The gas sensor exhibits superior selectivity for methylbenzene gas when compared to other gases. The gas sensor can be easily and mass produced according to the production method of the present invention and is not affected by the microstructures of the material forming the gas-sensitive layer. The present invention relates to a gas sensor exhibits a negligible sensitivity of benzene, formaldehyde, and alcohol and exhibits significantly high selectivity and sensitivity of methylbenzene gas such as xylene and toluene when the NiO sensor material with a hierarchical structure favorable to gas dispersion and response is doped with Cr. | 2016-01-28 |
20160025696 | Heated Graphite Scrubber to Reduce Interferences in Ozone Monitors - The present invention provides a means of greatly reducing interferences from mercury vapor, UV-absorbing compounds and water vapor in the measurement of ozone by UV absorbance. A heated graphite scrubber destroys greater than 99% of ozone passing through it while reducing biases from typical atmospheric UV-absorbing interferents by large factors compared to conventional ozone scrubbers. Substitution of a heated graphite scrubber in place of traditional ozone scrubbers such as hopcalite, metal oxides and heated silver scrubbers, results in a more accurate measurement of ozone by reducing the responses to UV-absorbing interferences and water vapor. The heated graphite scrubber also may be used in combination with other ozone sensors, such as electrochemical and HMOS sensors, to provide a reference measurement with ozone selectively removed and thus greatly reduce contributions from interfering species in those measurement devices as well. | 2016-01-28 |
20160025697 | METHODS FOR EVALUATING INSECT RESISTANCE IN A PLANT - Methods are provided for evaluating the insect resistance of a plant of interest. Specifically, methods are provided for high-throughput screening of soybean plants for resistance to kudzu bugs and stink bugs, including the brown marmorated stink bug and the southern green stink bug. In some embodiments, infesting emergent soybean seedlings with second instar stink bug nymphs and maintaining the nymphs in a closed environment with the seedling for only about 7 days allows evaluation of the stink bug resistance of a soybean variety of interest. Also provided are insect resistant plants, particularly plants resistant to kudzu bugs and stink bugs, as well as seeds produced by the resistant plants. Plants disclosed herein can be used to transfer the resistant trait into plant lines of interest. | 2016-01-28 |
20160025698 | METHOD FOR DETERMINING ECOLOGICAL RISKS OF POLYCYCLIC AROMATIC HYDROCARBON IN WATER BODY - The present disclosure discloses a method for determining ecological risks of polycyclic aromatic hydrocarbon in a water body. The method may include (1) screening representative species of a water ecological system in a region; (2) obtaining toxicity data of benzoapyrene; (3) calculating benzoapyrene concentration values HC5 of 95% of species in the protected water ecological system; (4) determining types of polycyclic aromatic hydrocarbon pollutants and corresponding environmental concentrations thereof by sampling, and analyzing concentration distribution characteristics of various polycyclic aromatic hydrocarbons; (5) calculating ecological risk quotient values RQi of specific polycyclic aromatic hydrocarbon pollutants; and (6) calculating a total ecological risk quotient value RQt and confirming concrete ecological risks. The method may analyze whether potential risks caused by the polycyclic aromatic hydrocarbon pollutants are acceptable, and determine whether the total level of the ecological risks of the water body needs to be controlled. | 2016-01-28 |
20160025699 | DETERMINATION OF THE DISTRIBUTION OF REACTIVE AND NON-REACTIVE SULFUR IN PETROLEUM AND ITS FRACTIONS - A method to determine the distribution of non-reactive sulfur compounds and reactive sulfur compounds in petroleum samples by separating non-reactive sulfur compounds from reactive sulfur compounds in a petroleum composition includes the step of contacting the petroleum composition with a Ag-containing cation exchange media. The petroleum composition and the Ag-containing cation exchange media are contacted with a non-reactive sulfur compound solvent capable of eluting the non-reactive sulfur compounds in the presence of the Ag-containing cation exchange media and incapable of eluting the reactive sulfur compounds in the presence of the Ag-containing cation exchange media at the conditions of the exchange. The non-reactive sulfur compounds are eluted from the media with the non-reactive sulfur compound solvent to provide a first fraction. The amount of non-reactive sulfur compounds in the first fraction is then determined. | 2016-01-28 |
20160025700 | METHOD AND PROBE FOR MEASURING BUOYANCY IN CONCRETE - The method can determine a density of concrete based on the measured buoyancy of a buoy immersed in fresh concrete contained in a ready mix drum and rotatable therein as the drum is rotated, the method can include obtaining a first measurement of a force applied to the buoy while the buoy is being moved tangentially in the fresh concrete, obtaining a second measurement of a force applied to the buoy while the buoy is being moved tangentially in the fresh concrete by rotation of the cylindrical wall, obtaining an indication of the buoyancy of the buoy in the concrete including factoring out the yield effect based on at least the first measurement and the second measurement. | 2016-01-28 |
20160025701 | Method to sort cells on the basis of radionuclide uptake - A method of sensing radionuclides in cells is provided that includes exposing a cell of interest to a radiolabeled molecule, encapsulating the cell of interest with a chemical sensor in an encapsulant to hold the cell of interest and the chemical sensor in proximity, where the radiolabeled molecule decays to emit an energetic particle, and detecting a fluorescence or optical absorption signal in the chemical sensor induced by the radio molecule decay, using an illumination source and a detector, where single-cell analysis with the radiolabeled molecule is performed. | 2016-01-28 |
20160025702 | SYSTEMS, DEVICES AND METHODS FOR TRANSLOCATION CONTROL - Some embodiments of the present disclosure are directed to systems, methods and devices for controlling the transit of a molecule across a nanopore. Some embodiments are directed to a device comprising a first compartment, a second compartment, a first pair of electrodes comprising a first electrode provided in the first compartment and a second electrode provided in the second compartment, a partition separating the first compartment from the second compartment, an orifice provided in the partition, a second pair of electrodes arranged proximate the orifice, the second pair of electrodes being functionalized with molecules, and a tunnel gap comprising the spacing between the second pair of electrodes. | 2016-01-28 |
20160025703 | Nucleic Acid Probes, their Synthesis and Use - The invention provides a method of probing for a nucleic acid comprising: contacting a nucleic acid solution with an oligonucleotide probe labelled with an electrochemically active marker, providing conditions at which the probe is able to at least partially hybridise with any complementary target sequence which may be present in the nucleic acid solution, selectively degrading either hybridised, partially hybridised or unhybridised nucleic acid probe, and electrochemically determining information relating to the electrochemically active marker. The invention further provides novel molecules with use in methods of the invention. | 2016-01-28 |
20160025704 | METHODS FOR IDENTIFYING NEUROPROTECTIVE PKC ACTIVATORS - The present disclosure is directed to methods of identifying neuroprotective PKC activators comprising analyzing candidate PKC activators to determine if they are non-tumorigenic, non-toxic, accessible to the brain, have α and ε specificity, result in minimal down regulation of the ε isozyme, are synapatogenic, and are anti-apoptotic. The methods disclosed herein may further comprise analyzing candidate PKC activators to determine whether they are neuroprotective against ASPD, protect against in vivo neurodegeneration, enhance learning and memory in normal animal models, induce downstream synaptogenic biochemical events, activate A-β degrading enzymes, inhibit GSK-3β, and/or activate alpha-secretase. | 2016-01-28 |
20160025705 | PROCESS FOR ASSESSING RISK OF SUBSTANCE ADMINISTRATION - A process for assessing risk that administration of a substance will suppress immune competence in a population of subjects is provided. Such a substance may be a substance related to, contained in or derived from a tobacco product or, more generally, a substance concerning which it is desired to assess risk of administration of the substance. | 2016-01-28 |
20160025706 | METHOD OF MEASURING HUMAN CYP3A INDUCIBILITY - A method for measuring human CYP3A inducibility upon administration of a test drug, characterized in that a non-human animal to which a test drug is administered or a population of human cells cultured in a medium containing a test drug is infected with viruses (A) and (B); virus (A) being an adenovirus which is used as a vector and engineered by incorporating thereto a detectable reporter gene and at least 3 human PXR binding regions falling within an untranslated region of a human CYP3A gene, and virus (B) being an adenovirus which is used as a vector and engineered by incorporating thereto a human PXR cDNA; and subsequently expression level of the reporter gene is determined in the non-human animal or the cultured human cells. | 2016-01-28 |
20160025707 | PROCESS FOR THE MEASUREMENT OF THE POTENCY OF GLATIRAMER ACETATE - The subject invention provides a process for measuring the relative potency of a test batch of glatiramer acetate. In addition, the subject invention provides a process for preparing a batch of glatiramer acetate as acceptable for pharmaceutical use. | 2016-01-28 |
20160025708 | METHOD FOR TARGETTING GROWTH AND DEATH OF NEOPLASTIC CELLS BY BURSTS OF ENERGIES FROM CELLULAR ENERGY EMISSIONS - The embodiments herein disclose a non-invasive method of using bursts of energies/electromagnetic field energies from cells to reduce or arrest the growth rate, proliferation of cancer cells/neoplastic cells. The energy from cells induces apoptosis in cancer cells, without harming normal cells beyond their physiologic threshold of survival are provided. The embodiments herein disclose a method for treatment of cancer/neoplastic cell in human or animals within the context of cancer therapeutics. A cell culture plate is incubated. This plate serves as the source of bursts energies/electromagnetic field energies. Further with a device the bursts of energies are targeted to another plate having cells for one week. After one week the microscopic examination is done. The rate of growth of cell is six to seven pulsatile cells per square centimetre. The energy from cells kills cancer cells, induce apoptosis, stimulate growth phase in cell culture and enables harmonics therapy. | 2016-01-28 |
20160025709 | HIGH THROUGHPUT DNA DAMAGE QUANTIFICATION OF HUMAN TISSUE WITH HOME-BASED COLLECTION DEVICE - Kits, methods and systems for providing a service to provide a subject with information regarding the state of a subject's DNA damage. Collection, processing and analysis of samples are also described. | 2016-01-28 |
20160025710 | INTERNAL FOCUS REFERENCE BEADS FOR IMAGING CYTOMETRY - The invention generally relates to analytical and monitoring systems useful for analyzing and measuring cells and biological samples. More particularly, the invention provides systems and methods for internal calibration and focus reference for cytometry imaging. | 2016-01-28 |
20160025711 | FLUORESCENT MARKERS AND METHODS FOR IMAGING DISEASES - Methods and fluorescent probes that detect the presence of diseased cells such as cancer. The fluorescent probes are cloaked, turn-on probes having the fluorescence reporter released only in the presence of enzymes typically over-expressed in diseased and cancerous tissue. Probes include a fluorescent napthalimide reporter with a quinoidal moiety cloak. | 2016-01-28 |
20160025712 | COMPOSITIONS AND METHODS FOR PREDICTING AGE OF ONSET OF A LYSOSOMAL STORAGE DISEASE OR A DISEASE ASSOCIATED WITH A LYSOSOMAL DEFECT - The present invention features diagnostic compositions and methods for predicting the age of onset of a lysosomal storage disease or a disease associated with a lysosomal defect in subject. | 2016-01-28 |
20160025713 | SITE-SPECIFIC LABELING OF AFFINITY TAGS IN FUSION PROTEINS - The present invention provides methods and fluorescent compounds that facilitate detecting and labeling of a fusion protein by being capable of selectively binding to an affinity tag. The fluorescent compounds have the general formula A(B)n, wherein A is a fluorophore, B is a binding domain that is a charged chemical moiety, a protein or fragment thereof and n is an integer from 1-6 with the proviso that the protein or fragment thereof not be an antibody or generated from an antibody. The present invention provides specific fluorescent compounds and methods used to detect and label fusion proteins that contain a poly-histidine affinity tag. These compounds have the general formula A(L)m(B)n wherein A is a fluorophore, L is a linker, B is an acetic acid binding domain, m is an integer from 1 to 4 and n is an integer from 1 to 6. The acetic acid groups interact directly with the positively charged histidine residues of the affinity tag to effectively label and detect a fusion protein containing such an affinity tag when present in an acidic or neutral environment. | 2016-01-28 |
20160025714 | APPARATUS AND METHOD FOR DETECTING AND COUNTING RARE CELLS IN BLOOD - The present invention relates to an apparatus and method for detecting and enumerating a rare cell in blood. The apparatus comprises a sample collector configured to collect a blood sample and receive a complex in which a target antibody and a marker are coupled; a measuring kit connected to the sample collector in such a way that a mixture of the blood sample and the complex is injected into the measuring kit, thereby individually trapping a blood cell; and a detector configured to detect and enumerate the rare cell having an antigen-antibody reaction with the target antibody among the blood cell trapped in the measuring kit. | 2016-01-28 |
20160025715 | MULTIPLEXING WITH SINGLE SAMPLE METERING EVENT TO INCREASE THROUGHPUT - An assay device includes a support, test elements arranged thereover, and a diverter defining a common sample addition area of the device. The diverter conducts respective portions of a fluidic sample from the area to each of the test elements. Another assay device includes the test elements, one a dry slide element, disposed over the support at least partly in proximity to each other to define a common sample addition area. Apparatus for analyzing a sample includes an assay device having the test elements, one a dry slide element. A controller operates a metering mechanism, to apply the sample to the assay device, an incubator, and a measurement device per a timing protocol to determine a characteristic of the sample. Methods for enabling an assay device to perform multiple tests based upon a single sample metering event include are also described. | 2016-01-28 |
20160025716 | MULTISIGNAL LABELING REAGENTS AND PROCESSES AND USES THEREFOR - Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents. | 2016-01-28 |
20160025717 | HYPOSIALYLATION DISORDERS - Methods are disclosed for diagnosing a hyposialylation disorder. Methods are also disclosed for determining the effectiveness of a therapeutic agent for treatment of a hyposialylation disorder in a subject. These methods include measuring an amount of monosialylated Thomsen-Friedenreich (ST) antigen and measuring an amount of non-sialylated Thomsen-Friedenreich antigen (T) in a biological sample, such as a serum or plasma sample from the subject, and determining the ratio of T to ST. | 2016-01-28 |
20160025718 | NOVEL ASSAY - The invention relates to a method for detection of at least two cytokeratins selected from the group consisting of cytokeratin 8, 18 and 19, and/or soluble fragments thereof, in a sample, comprising the steps of contacting said sample with a solid phase having immobilized thereon a first antibody having specificity for cytokeratin 8, a second antibody having specificity for cytokeratin 18 and, optionally,a third antibody having specificity for a first epitope of cytokeratin 19; allowing cytokeratin and/or soluble fragments thereof in said sample to bind to said first, second and optionally third antibodies thereby forming complexes; contacting said complexes with a first labelled antibody having specificity for a dimer of cytokeratin 8 and 18 and optionally a second labelled antibody having specificity for a second epitope of cytokeratin 19; allowing said first and second labelled antibodies to bind to said complexes; and detecting said first labelled antibody and said second labelled antibody bound to said complexes. The invention further relates to a method for quantitative determination of soluble fragments of at least two of cytokeratin 8, 18 and 19 in a sample and to a kit-of-parts for performing the method according to the invention. | 2016-01-28 |
20160025719 | HIGHLY SENSITIVE IMMUNOASSAY FOR RAPID QUANTIFICATION OF MENINGOCOCCAL CAPSULAR POLYSACCHARIDE ANTIGENS - The present disclosure relates to the field of immunoassays for Gram negative bacteria, in particular | 2016-01-28 |
20160025720 | DEVICES AND METHODS OF CELL CAPTURE AND ANALYSIS - The present invention provides a device for isolating target biomolecules or cells from samples, particularly biological samples. In particular, the device comprises a loading mixture, which contains the biological sample and a first binding entity that specifically binds to the target biomolecule or target cell; and a micro-channel coated with a second binding entity that binds directly or indirectly to the first binding entity. Methods of capturing, detecting, and/or evaluating target biomolecules or target cells (e.g. cancer cells) in biological samples are also disclosed. | 2016-01-28 |