05th week of 2011 patent applcation highlights part 43 |
Patent application number | Title | Published |
20110027816 | BIOSENSOR SYSTEM, SENSOR CHIP, AND METHOD OF MEASURING ANALYTE CONCENTRATION IN BLOOD SAMPLE - The present invention provides a biosensor system that can prevent a measurement error caused by the temperature of the environment in use from occurring. A biosensor system | 2011-02-03 |
20110027817 | TAU PROTEIN SCREENING ASSAY - This invention is directed to methods for determining if a test compound can ameliorate tau protein induced reduction of long term potentiation in a neural structure. The invention is also directed to methods for determining if a test compound can re-establish or rescue synaptic function in a neural structure following damage by tau proteins. Also encompassed by disclosures in this invention are methods to determine if a test compound can increase synaptic function in a neural structure contacted with tau proteins and methods for determining if a test compound is capable of treating Alzheimer's disease or other tauopathies in a subject. | 2011-02-03 |
20110027818 | APPARATUS AND METHOD FOR DETECTING ZINC IONS - The present invention provides apparatuses and methods for determining zinc ion concentration in a fluid sample. Some apparatuses of the invention include (i) a light source designed to emit an excitatory light at a first known wavelength that activates a fluorescent emission having a second and different wavelength by at least one selected fluorescent reporter probe that generates a different fluorescent response when bound to zinc ion; (ii) at least one sample-holding component adapted to hold a liquid sample in a pathway of the excitatory light; (iii) a photodetector for measuring fluorescent emission intensity generated by fluorescent reporter probe bound to zinc ion within the liquid sample; and (iv) electronic means for creating a data signal that correlates with fluorescent emission intensity generated by fluorescent reporter probe bound to zinc ion in the liquid sample to the free zinc ion concentration. Such apparatuses and methods can be used to determine the presence of or the risk of having prostate cancer in a subject. | 2011-02-03 |
20110027819 | USE OF SFRP-3 IN THE ASSESSMENT OF HEART FAILURE - Disclosed is a method for assessing heart failure in vitro including the steps of measuring in a sample the concentration of the marker SFRP-3, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration determined in for SFRP-3 and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of SFRP-3 as a marker protein in the assessment of heart failure, a marker combination comprising SFRP-3 and a kit for measuring SFRP-3. | 2011-02-03 |
20110027820 | ENGINEERING ENZYMES THROUGH GENETIC SELECTION - The embodiments of the present disclosure provide a versatile system, and methods of using, that allow for the selection of variant nuclear receptor ligand binding domains, or for the selection of variant enzymes, or combinations thereof, that may have an enhanced ability to synthesize a nuclear receptor ligand or a precursor thereof. The present disclosure provides yeast cells comprising: a yeast transcription modulating system comprising a nucleic acid expression system encoding a nuclear receptor ligand-binding domain operably linked to a DNA-binding domain, a second nucleic acid expression system encoding an adapter polypeptide comprising a coactivator domain operably linked to a yeast transcriptional activator, a heterologous enzyme system for generating a nuclear receptor ligand, and a selective genetic locus expressed in the presence of the recombinant nuclear receptor polypeptide and a nuclear receptor ligand specifically bound to the recombinant nuclear receptor polypeptide. The present disclosure further methods of use of the modified yeast cell system for identifying variant nuclear receptor ligand binding domains or variant enzymes synthesizing a nuclear receptor ligand. | 2011-02-03 |
20110027821 | METHOD OF BIOASSAYING YOKUKANSAN - The invention intends to find out a bioassay system with an in-vitro test capable of ensuring the higher quality of yokukansan, and provides a bioassay method for yokukansan, comprising adding glutamate in an amount sufficient to induce cell death and yokukansan to a medium for culturing cells, and evaluating pharmacological activity value of yokukansan from viability of the cultured cells in the medium. | 2011-02-03 |
20110027822 | SYSTEMIC LUPUS ERYTHEMATOSUS - This document relates to methods and materials involved in diagnosing SLE. For example, this document relates to methods and materials involved in diagnosing SLE, diagnosing severe SLE, and assessing a mammal's susceptibility to develop severe SLE. For example, this document provides nucleic acid arrays that can be used to diagnose SLE in a mammal. Such arrays can allow clinicians to diagnose SLE based on a simultaneous determination of the expression levels of many genes that are differentially expressed in SLE patients as compared to healthy controls. In addition, methods and materials for assessing SLE activity, determining the likelihood of experiencing active SLE, and detecting SLE treatment effectiveness are provided herein. | 2011-02-03 |
20110027823 | METHOD AND REAGENTS FOR DETECTING THE PRESENCE OR ABSENCE OF STAPHYLOCOCCUS AUREUS IN A TEST SAMPLE - A presence/absence test for | 2011-02-03 |
20110027824 | Method And Apparatus For Analyzing Body Fluids - A system and method for analyzing a specimen containing particles that can be difficult to differentiate. The system and method determines a first collective count of a selected group of particles in the specimen, treats at least a portion of the specimen to alter a subgroup of the selected group of particles, determines a second collective count of any of the selected group of particles in the treated portion of the specimen, and subtracts the second collective count from the first collective count to determine a differentiation count for the subgroup of particles altered by the treating of the specimen. The system and method is described with the example of determining concentrations of red and white blood cells in a specimen (e.g. spinal fluid), using auto-particle recognition techniques, without attempting to distinguish and count red versus white blood cells co-existing in the same specimen portion. | 2011-02-03 |
20110027825 | HIGH RESOLUTION CLASSIFICATION - The present invention relates to a method of determining pulse height distribution by using an apparatus comprising: an analogue to digital pulses height categorisation unit comparing the pulse to analogue threshold voltages and counting each event within each pulse height category using a micro controller. The method may comprise the steps of i) selecting a first set of threshold voltages, ii) performing a first measurement using the first set of threshold voltages, iii) selecting a new set of threshold voltages different from the first set of threshold voltages, iv) performing a new measurement using the new set of threshold voltages, v) determining cell size distribution based on the first measurement and the new measurement. The present invention further relates to an apparatus comprising an analogue to digital pulses height categorisation unit comparing the pulse to analogue threshold voltages, a micro controller configured for counting each event within each pulse height category, the micro controller further configured for i) selecting a first set of threshold voltages, ii) performing a first measurement using the first set of threshold voltages, iii) selecting a new set of threshold voltages different from the first set of threshold voltages, iv) performing a new measurement using the new set of threshold voltages, v) determining cell size distribution based on the first measurement and the new measurement. | 2011-02-03 |
20110027826 | LEUKOCYTE ANALYSIS METHOD AND ANALYSIS REAGENT FOR USE IN THE METHOD - The present invention provides a method for analyzing leukocytes, by which the leukocytes can be classified and measured stably with high accuracy even when a dilution ratio of a sample containing the leukocytes is low or a flow velocity during the analysis is slow, and an analysis reagent used for the analysis method. The analysis method of the present invention includes the steps of mixing a sample containing leukocytes and erythrocytes and an analysis reagent containing a surfactant that reacts with leukocytes; and measuring the leukocytes by passing a mixed solution of the sample and the analysis reagent through a fine through-hole, measuring a signal detected when the mixed solution passes through the fine through-hole, and classifying and counting the leukocytes in the sample. The analysis reagent further contains a nonionic surfactant, and the nonionic surfactant has a sugar residue as a hydrophilic region and an aliphatic chain as a hydrophobic region. | 2011-02-03 |
20110027827 | INTEGRATED SYSTEM FOR PRODUCTION OF BIOFUEL FEEDSTOCK - Disclosed is a culture system for the production of algae biomass to obtain lipid, protein and carbohydrate. By integrating heterotrophic processes with a phototrophic process in parallel, this system provides year around production in colder climates. By integrating heterotrophic processes with a phototrophic process in series, this system creates a two-stage, separated mixed-trophic algal process that uses organic carbon and nutrients for the production of seed in the heterotrophic process, followed by release of cultured seed in large-scale phototrophic culture for cell biomass accumulation. Organic carbon source including waste materials can be used to feed the heterotrophic process. The production capacity ratio between the heterotrophic and the phototrophic processes can be adjusted according to season and according to the availability of related resources. The systems are used for producing and harvesting an algal biofuel feedstock as well as other potential high-value products. The sequence and approach enhances utilization of carbon and nutrient waste-streams, provides an effective method for controlling contamination, adds flexibility in regard to production and type of available products, and supplies greater economic viability due to maximized use of available growth surface areas. | 2011-02-03 |
20110027828 | Enzymatic Modification in a Continuously Regenerated Packed Bed Column - A process for the modification of a substrate comprising passing the substrate through a packed bed column of a specific volume of immobilized enzyme wherein the substrate enters the column at or near one end of the column (the ‘inlet end’) and the modified substrate exits at or near the opposite end of the column (the ‘outlet end’), a portion of the volume of immobilized enzyme is periodically removed at or near to the inlet end of the column, and an equivalent portion of immobilized enzyme is periodically added at or near to the outlet end of the column. | 2011-02-03 |
20110027829 | Methods and Compositions - The invention relates to a tRNA synthetase capable of binding N | 2011-02-03 |
20110027830 | USE OF AN ASPARTIC PROTEASE (NS24) SIGNAL SEQUENCE FOR HETEROLOGOUS PROTEIN EXPRESSION - The invention relates to heterologous polypeptide expression and secretion by filamentous fungi and vectors and processes for expression and secretion of such polypeptides. More particularly, the invention discloses the use of a signal sequence form an aspartic protease obtained from | 2011-02-03 |
20110027831 | PRODUCTION OF SIALYLATED N-GLYCANS IN LOWER EUKARYOTES - The present invention relates to eukaryotic host cells which have been modified to produce sialylated glycoproteins by the heterologous expression of a set of glycosyltransferases, including sialyltransferase and/or trans-sialidase, to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. Novel eukaryotic host cells expressing a CMP-sialic acid biosynthetic pathway for the production of sialylated glycoproteins are also provided. The invention provides nucleic acid molecules and combinatorial libraries which can be used to successfully target and express mammalian enzymatic activities (such as those involved in sialylation) to intracellular compartments in a eukaryotic host cell. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. | 2011-02-03 |
20110027832 | USE OF TAQ POLYMERASE MUTANT ENZYMES FOR NUCLEIC ACID AMPLIFICATION IN THE PRESENCE OF PCR INHIBITORS - The present invention generally relates to detection of a target nucleic acid in standard PCR, real-time PCR, RT PCR, and real-time RT PCR. One aspect of the invention provides mutant DNA polymerase enzymes that are resistant to PCR inhibitors, such as dye, blood, and soil. Another aspect of the invention provides for methods of real-time PCR assays using mutant DNA polymerase enzymes resistant to PCR inhibitors with samples containing dye, blood, and/or soil. Another aspect of the invention provides for methods of standard PCR assays using mutant DNA polymerase enzymes resistant to PCR inhibitors with samples containing blood and/or soil. | 2011-02-03 |
20110027833 | THERMOSTABLE TYPE-A DNA POLYMERASE MUTANTS WITH INCREASED POLYMERIZATION RATE AND RESISTANCE TO INHIBITORS - The present invention provides mutants of DNA polymerases having an increased rate of incorporation of nucleotides into nucleic acids undergoing polymerization and having an enhanced resistance to inhibitors of DNA polymerase activity. The mutant polymerases are well suited for fast PCR applications, for PCR amplification of targets in samples that contain inhibitors of wild-type polymerases, and for fast PCR amplification of samples containing DNA polymerase inhibitors. In exemplary embodiments, the mutants are mutants of Taq DNA polymerase. | 2011-02-03 |
20110027834 | Carry-Over Protection in Enzyme-Based Dna Amplification Systems Targeting Methylation Analysis - The invention refers to a method for providing a decontaminated template nucleic acid for enzymatic amplification reactions suitable for DNA methylation analysis. This method is characterized by the following steps: a) incubating a nucleic acid with a chemical reagent or an enzyme-containing solution, whereby the unmethylated cytosine bases are converted into uracil bases, b) mixing the template nucleic acid from step a) with the components required for an enzyme-mediated amplification reaction, including at least two oligonucleotides, whereby at least one of said oligonucleotides comprises i) at least one sequence part that hybridizes with a sequence of the template nucleic acid to be amplified, and ii) at least one sequence part that constitutes a recognition site for a DNA cleaving enzyme that cleaves DNA downstream of said recognition site and c) adding to this mixture a DNA cleaving enzyme, which specifically binds to the at least one sequence part that is a recognition site, and d) incubating the mixture, whereby nucleic acids containing said recognition site for a DNA cleaving enzyme are degraded. | 2011-02-03 |
20110027835 | METHODS OF MODIFYING NUCLEIC ACIDS IN HOST CELLS - A method of double crossover homologous recombination in a host cell comprising: a first homologous recombination event between a donor DNA molecule comprising a first element of a selectable allele and an acceptor DNA molecule comprising a second element of the selectable allele in the host cell, thereby to form a product of the first homologous recombination event in the host cell; and a second homologous recombination event within the product of the first homologous recombination event, thereby to form a product of the second homologous recombination event in the host cell which confers a selectable phenotype on the host cell, wherein the selectable phenotype arises following and in dependency on the formation of a selectable allele from the first and second elements of the selectable allele. | 2011-02-03 |
20110027836 | Glucoamylase Variants - The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates. | 2011-02-03 |
20110027837 | PROCESSING BIOMASS - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce ethanol and/or butanol, e.g., by fermentation. | 2011-02-03 |
20110027838 | Sphingomonas Strains Producing Greatly Increased Yield Of PHB-Deficient Sphingan (Diutan) - PHB-deficient | 2011-02-03 |
20110027839 | MIXTURE OF CULTURE PRODUCTS OF FILAMENTOUS FUNGI OR DRIED PRODUCT THEREOF, WHICH EXHIBITS CELLULOLYTIC ACTIVITY, AND METHOD FOR PRODUCING GLUCOSE USING THE SAME - An objective of the present invention is to provide a method for enzymatically saccharifying a cellulosic substance in an extremely efficient, simple, and inexpensive manner. A solution to the object is a mixture or a dried product thereof exhibiting cellulolytic activity containing a culture liquid or a supernatant liquid of a genus | 2011-02-03 |
20110027840 | MICROORGANISM PRODUCING GLUTAMIC ACID IN HIGH YIELD AND A PROCESS OF PRODUCING GLUTAMIC ACID USING THE SAME - Disclosed herein are mutant strains, KCCM-10784P and KCCM-10785P, which are obtained through gene manipulation of | 2011-02-03 |
20110027841 | METHOD FOR PREPARATION OF OXYLIPINS - The invention provides methods of producing oxygenated derivatives of polyunsaturated fatty acids (PUFAs). | 2011-02-03 |
20110027842 | Method for Producing Monosaturated Glycerides - A process for producing a glyceride product which is enriched in monounsaturated fatty acids relative to the starting glyceride comprising the steps: (a) alcoholysis of triglycerides employing lipolytic enzymes selective for saturated fatty acids and/or lipolytic enzymes selective for the 1-position, the 3-position or both positions in a glyceride; and (b) separation of fraction A which is enriched in saturated fatty acid esters from fraction B which is enriched in monounsaturated glycerides. | 2011-02-03 |
20110027843 | METHOD FOR PRODUCING POLYHYDROXYALKANOATE - A method for producing polyhydroxyalkanoate (PHA), comprising (i) culturing in a culture medium comprising terephthalic acid and/or a salt thereof and/or an ester thereof one or more bacterial strains which are capable of accumulating PHA from terephthalic acid or a salt or ester thereof and which are selected from | 2011-02-03 |
20110027844 | METHOD FOR PRODUCING QUINONES - A method for conveniently and efficiently producing quinones, and particularly menaquinone, from a microorganism is provided. The present invention relates to a method for producing quinones, comprising culturing a microorganism that produces quinones in the presence of a porous carrier. | 2011-02-03 |
20110027845 | ENHANCED ETHANOL AND BUTANOL PRODUCING MICROORGANISMS AND METHOD FOR PREPARING ETHANOL AND BUTANOL USING THE SAME - The present invention relates to a recombinant microorganism having an enhanced ability to produce ethanol and butanol and a method for preparing ethanol and butanol using the same, and more particularly to a recombinant microorganism having an enhanced ability to produce ethanol and butanol, into which a gene encoding CoA transferase and a gene encoding alcohol/aldehyde dehydrogenase are introduced, and to a method for preparing ethanol and butanol using the same. The recombinant microorganism according to the present invention, obtained by manipulating metabolic pathways of microorganisms, is capable of producing butanol and ethanol exclusively without producing any byproduct, and thus is useful as a microorganism producing industrial solvents and transportation fuel. | 2011-02-03 |
20110027846 | CONTROL OF BACTERIA IN FERMENTATION PROCESSES - A method of producing a fermentation-based product comprises fermenting a sugar-containing medium with yeast in the presence of an organic biocide and a quaternary ammonium compound, in amounts sufficient to reduce or control a bacterial population in the sugar-containing medium. The additives enable reduction or elimination of antibiotics while still showing desirably reduced percent infection, process variability and interference with yeast viability. | 2011-02-03 |
20110027847 | HEXOSE-PENTOSE COFERMENTING YEAST HAVING EXCELLENT XYLOSE FERMENTABILITY AND METHOD FOR HIGHLY EFFICIENTLY PRODUCING ETHANOL USING THE SAME - Genetic recombinant yeast expressing xylose reductase (XR), (wild-type or mutant) xylitol dehydrogenase (XDH), and xylulokinase (XK) and a method for highly efficiently producing ethanol from xylose using the yeast are provided. | 2011-02-03 |
20110027848 | METHOD OF PRODUCING COUPLED RADICAL PRODUCTS FROM BIOMASS - A method that produces coupled radical products from biomass. The method involves obtaining a lipid or carboxylic acid material from the biomass. This material may be a carboxylic acid, an ester of a carboxylic acid, a triglyceride of a carboxylic acid, or a metal salt of a carboxylic acid, or any other fatty acid derivative. This lipid material or carboxylic acid material is converted into an alkali metal salt. The alkali metal salt is then used in an anolyte as part of an electrolytic cell. The electrolytic cell may include an alkali ion conducting membrane (such as a NaSICON membrane). When the cell is operated, the alkali metal salt of the carboxylic acid decarboxylates and forms radicals. Such radicals are then bonded to other radicals, thereby producing a coupled radical product such as a hydrocarbon. The produced hydrocarbon may be, for example, saturated, unsaturated, branched, or unbranched, depending upon the starting material. | 2011-02-03 |
20110027849 | Formation Pretreatment with Biogenic Methane Production Enhancement Systems - Systems for enhanced in-situ or perhaps even ex-situ biogenic methane production from hydrocarbon-bearing formations ( | 2011-02-03 |
20110027850 | In situ precipitation of calcium carbonate (CaCO3) by indigenous microorganisms to improve mechanical properties of a geomaterial - A method for increasing the concentration of calcium carbonate in a geomaterial that contains indigenous microorganisms capable of hydrolyzing urea to ammonia, which method includes enriching the geomaterial with a source of nutrients, adding urea to the geomaterial which is hydrolyzed to ammonia and which raises the pH of the geomaterial, and adding a source of calcium ions to the geomaterial. Carbonate ions obtained by the hydrolysis of the urea combine with calcium ions to form calcium carbonate. | 2011-02-03 |
20110027851 | COMPOSITIONS, METHODS AND USES FOR BIOSYNTHETIC PLASMID INTEGRATED CAPTURE ELEMENTS - Embodiments herein report compositions, systems and methods for making and using plasmid vectors and nanotube complexes. In certain embodiments, compositions, systems and methods herein include making plasmid vectors having aptamer inserts. In some embodiments, methods disclosed herein may be used to rapidly generate large quantities of plasmid vectors having aptamer inserts directed to a particular target agent. Other aspects concern plasmid constructs associated with organic semiconductors. Yet other aspects concern complexes of nanotubes associated with dsDNA aptamers and tracking molecules. | 2011-02-03 |
20110027852 | Processing lignocellulosic biomass to fixed, high levels of dry matter content. - The invention relates in general to methods of processing lignocellulosic biomass and to methods of pre-treatment of lignocellulosic pretreated with steam biomass. In particular, the invention provides methods which fix moisture levels in lignocellulosic biomass to levels near the inherent water holding capacity of the material. | 2011-02-03 |
20110027853 | Phantom for the experimental in-vitro validation of radiation procedures under the influence of motion, taking into account the biological effective dose - A phantom device for in-vitro validation of radiation procedures under motion influence in consideration of an effective biological dose includes a phantom having a first biological detector with a first biological sample. The first biological sample includes a plurality of culturing and irradiation elements. Each of the culturing and irradiation elements are provided with a respective biological sub-sample so that the first biological detector is configured as a spatially resolving biological detector. A first motion device is configured to move the first biological detector so as to simulate a motion of a target volume. | 2011-02-03 |
20110027854 | METHOD FOR CONCENTRATING VIRUSES, METHOD FOR CONCENTRATING CELLS OR BACTERIA, AND MAGNETIC COMPOSITE - A method for concentrating viruses includes applying a magnetic force to a mixture containing: sugar chain-immobilized magnetic metal nano-particles each having a structure in which a sugar chain-immobilized metal nano-particle is bound to a first magnetic nano-particle; second magnetic particles with mean particle size larger than that of the sugar chain-immobilized magnetic metal nano-particles; and a specimen. Each sugar chain-immobilized metal nano-particle has a structure where a ligand-conjugate is bound to a metal nano-particle via sulfur atoms. The ligand-conjugate has a structure where a linker compound's amino group is connected to a sugar chain having a reducing terminal. The linker compound includes, in molecules thereof, an amino group, sulfur atoms, and a hydrocarbon chain having carbon-nitrogen bonds. This allows short-time concentration of viruses in a sufficient amount almost equal to that of centrifugation concentration, allowing safely and effectively concentrating target viruses, resulting in prompt, easy, and highly sensitive detection and identification of viruses. | 2011-02-03 |
20110027855 | Maize Cellulose Synthases and Uses Thereof - The invention provides isolated cellulose synthase nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering cellulose synthase levels in plants. The invention further provides recombinant expression cassettes, host cells, and transgenic plants comprising said nucleic acids. | 2011-02-03 |
20110027856 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY - The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful. | 2011-02-03 |
20110027857 | Methods of improving the introduction of DNA into bacterial cells - The present invention relates to methods of improving the introduction of DNA into bacterial host cells. | 2011-02-03 |
20110027858 | Method of Modifying Fungal Morphology - Provided is a method of modifying fungal morphology. The method comprises introducing an amount of a surfactant to a fungus, or to a growing mixture comprising a fungus, wherein said amount of a surfactant is sufficient to induce a change in the morphology of said fungus. | 2011-02-03 |
20110027859 | METHOD FOR PRODUCING AMINOPEPTIDASE - Disclosed is an efficient method for production of aminopeptidase. The method comprises either transforming host bacteria with an aminopeptidase gene and with a neutral protease gene, or transforming some part of host bacteria with an aminopeptidase gene while transforming the other part of the host bacteria with a neutral protease gene, culturing in a medium the hose bacteria transformed with the aminopeptidase gene and with the neutral protease gene, or culturing a mixture of the host bacteria transformed with the aminopeptidase gene and the host bacteria transformed with the neutral protease gene, to let both the aminopeptidase and the neutral protease be expressed, and collecting the aminopeptidase thus produced from the culture mixture. | 2011-02-03 |
20110027860 | GENE ENCODING CHONDROITINASE ABC AND USES THEREFOR - Nucleic acid sequences coding for the chondroitinase ABC gene and isolated chondroitinase ABC protein produced in a host cell transformed with a nucleic acid vector directing the expression of a nucleotide sequence coding for chondroitinase ABC protein are described. Chondroitinase ABC prepared by chemical synthesis is also described. Monoclonal and polyclonal antibodies which are specifically reactive with chondroitinase ABC protein are disclosed. The isolated chondroitinase ABC can be used in methods of treating intervertebral disc displacement, promoting neurite regeneration, and detecting galactosaminoglycans. | 2011-02-03 |
20110027861 | Desiccated Biologics And Methods Of Preparing The Same - The present invention provides compositions comprising desiccated biologics comprising a cell, protein, virus, nucleic acid, carbohydrate, or lipid, or any combination thereof, along with at least one membrane penetrable sugar, and at least one membrane impenetrable sugar, wherein the moisture content is from 5% to 95%, and to methods of preparing the same, and to methods of treating animals using the same. | 2011-02-03 |
20110027862 | SAMPLE STABILIZATION - This disclosure relates to reagents, compositions, methods for stabilising RNA in an RNA-containing sample by contacting the sample with guanidine and a metal ion to form a stabilised RNA-containing composition in which the metal ion is present at a concentration which is no more than 20 mM, and the metal ion is derived from a metal other than from a Group 1 or Group 2 metal. | 2011-02-03 |
20110027863 | LABORATORY VESSEL WITH SHIFTABLE VESSEL CLOSURE - The present invention pertains to vessels with a vessel closure, and in particular to laboratory vessels with a shiftable closure assembly. The laboratory vessel comprises a container comprising an outwardly extending neck with an opening which provides access to the interior of said container, at least one guiding device comprising a guided member and a guiding member, a closure assembly comprising a vessel closure and at least one guided member which is part of said at least one guiding device, which is characterized in that said vessel closure is arranged to be shifted away from said opening to provide access to the interior of the container, wherein said at least one guiding device guides the shifting of the closure assembly and retains it in connection with the container even in the position in which the vessel closure is removed from the opening. | 2011-02-03 |
20110027864 | PROCESS FOR PREPARING 2-HYDROXY-4-SUBSTITUTED PYRIDINES - A process for preparing a 2-hydroxy-4-substituted pyridine compound using a microbiological method, a novel microorganism, and a novel compound are provided. | 2011-02-03 |
20110027865 | EVERNINOMICIN BIOSYNTHETIC GENES - This invention is directed to nucleic acids which encode the proteins that direct the synthesis of the orthosomycin everninomicin and to use of the nucleic acids and proteins to produce compounds exhibiting antibiotic activity based on the everninomycin structure. The DNA sequence for the gene clusters responsible for encoding everninomicin biosynthetic genes, which provide the machinery for producing everninomicin, are provided. Thus, this invention provides the nucleic acid sequences needed to synthesize novel eveminomicin-related compounds based on eveminomicin, arising from modifications of the DNA sequence designed to change glycosyl and modified orsellinic acid groups contained in everninomicin. A | 2011-02-03 |
20110027866 | CARRIER PIECE AND METHOD FOR PREPARING CULTURE MEDIA - The method provides a simple, accurate and inexpensive way to prepare culture media for conducting microbiological analysis with an absolute minimum of facilities, extraneous equipment and time consuming procedures. The invention introduces the use of a carrier piece that is suitable for carrying a reactant material for combining with growth media. The carrier piece may be formed using (non-)porous, (non-)absorbent material, including paper, plastic, gum, fabric, or acetate. The carrier piece carries a single one or a combination of various reactant materials that are released into the medium or medium/test sample mixture upon contact therewith. The reactant materials may include, among other things, nutrients, inhibitors, including antibiotics and bile salts, enzyme substrates, and/or a catalyst for a gelling agent contained in the growth medium. The growth medium, the carrier piece with the appropriate reactant material(s), and the test sample can be easily packaged and sold separately or as a kit and used anywhere. | 2011-02-03 |
20110027867 | Methods and compositions for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs - This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in viva | 2011-02-03 |
20110027868 | APPARATUS AND METHOD FOR DEHYDRATING BIOLOGICAL MATERIALS - An apparatus for dehydrating a liquid sample of biological material has a microwave waveguide that is open to the atmosphere. It has a microwave generator, means for introducing a container of the material into the waveguide, means for evacuating the container, means for rotating the container and means for removing the container from the waveguide. It can include means for moving the container through the waveguide and for sealing it. In a dehydration method, a container of the liquid sample is put into the open waveguide, evacuated, rotated at high speed and microwaved. The container of dehydrated material is then removed from the waveguide. The apparatus and method are particularly suitable for dehydrating vaccines. | 2011-02-03 |
20110027869 | Compositions for Chemical and Biological Defense - One aspect of the present invention relates to reactive compositions and methods of use thereof, wherein a metal oxide cluster is used to connect a reactive group (or groups) to the surface of a substrate. In certain embodiments, the reactive group in the compositions decomposes organophosphate agents through nucleophilic hydrolysis. In certain embodiments, the reactive group in the compositions is bactericidal. Remarkably, the use of metal oxide clusters in the disclosed compositions and methods permits incorporation of higher quantities of nucleophilic and bactericidal groups without the difficulties associated with having to pretreat the substrate prior to its association with the reactive groups. | 2011-02-03 |
20110027870 | BIOMASS CARRIERS, METHOD AND APPARATUS FOR MANUFACTURE THEREOF AND FLUID TREATMENT SYSTEMS AND METHODS UTILIZING SAME - A biomass carrier including a multiplicity of generally elongate plastic biomass attachment strips joined to each other at least one location therealong, the multiplicity of generally elongate plastic biomass attachment strips being mutually arranged to define a generally deformable biomass carrier including generally outer disposed biomass attachment strips and generally inner disposed biomass attachment strips. Apparatus and methods for manufacture of the biomass carrier as well as fluid treatment systems and methods using the biomass carrier are also disclosed. | 2011-02-03 |
20110027871 | Apparatus for Demineralizing Osteoinductive Bone - The invention is directed to an apparatus for producing demineralized osteoinductive bone. The apparatus demineralizes bone by subjecting bone, including, for example, ground bone, bone cubes, chips, strips, or essentially intact bone, to either a rapid high volume pulsatile acidification wave process or to a rapid continuous acid demineralization process. The pulsatile acidification wave process includes subjecting bone to two or more rapid pulse/drain cycles in which one or more demineralizing acids is rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel. The continuous acid demineralization process includes subjecting bone to a continuous exchange of demineralizing acid solution in which the demineralizing acid solution is recirculated from the container holding the bone through an ion exchange media. Calcium and phosphate are thereby removed from the bone to produce a regenerated acid, and the regenerated acid is returned to the container holding the bone. Both processes allow bone to be rapidly demineralized to a precise and specific desired residual calcium level without sacrificing osteoinductivity. | 2011-02-03 |
20110027872 | CANTILEVER FOR MEASURING INTRA-CELLULAR AND INTER-CELLULAR MICROSPACES - A cantilever for measuring intra-cellular and inter-cellular microspaces of the present invention includes a support portion, a lever portion provided to the support portion so as to protrude therefrom, and a probe portion provided near a free end of the lever portion. The probe portion includes a conductive probe made of a carbon-based material, and an insulating film to coat a periphery of the conductive probe. | 2011-02-03 |
20110027873 | MICRO-NANO FLUIDIC BIOCHIP FOR ASSAYING BIOLOGICAL SAMPLE - Disclosed is a micro-nano fluidic biochip for assaying a biological sample comprising a first substrate, a second substrate and a third substrate which are sequentially stacked from bottom to top, wherein an upper channel assembly disposed on the second substrate is coupled with the lower channel assembly provided on the first substrate, to form a microfluidic channel, and the microfluidic channel has nano interstices formed at both sides thereof, the nano interstices having a height less than that of the center of the channel. | 2011-02-03 |
20110027874 | Packed Bed for Nucleic Acid Capture and Amplification - A system for nucleic acid capture and amplification comprising introducing a sample potentially containing the nucleic acid into a packed bed wherein the nucleic acid adheres to the packed bed, introducing an amplification mix into the packed bed, and thermal cycling the packed bed and the nucleic acid between denaturation and annealing temperatures for PCR amplification. One embodiment provides an apparatus for DNA capture and amplification comprising a tubing or housing having a cavity, bed media in the cavity, and a heater operatively connected to the tubing or housing. | 2011-02-03 |
20110027875 | Inexpensive, Vertical, Production Photobioteactor - A production photobioreactor for culturing microalgae has a primarily vertical orientation of parallel transparent columns or tubes connected in a closed loop serpentine fashion. Generally no pump is required. The flow is maintained by gas diffusion in alternate columns (up columns) having a rate and volume as to provide an air lift with sufficient rate and volume to cause fluid to rise and cascade into adjacent “down” columns. Adequate mixing in the down columns is engendered by a bubble flow at a rate less than that of the up columns. | 2011-02-03 |
20110027876 | CRYOPREPARATION CHAMBER FOR MANIPULATING A SAMPLE FOR ELECTRON MICROSCOPY - The present invention relates to a cryopreparation chamber ( | 2011-02-03 |
20110027877 | RECIPIENT DEVICE AND METHOD TO PROTECT IN VITRO CULTURED EMBRYOS AND CELLS AGAINST ATOMOSPHERIC SHOCK - A recipient device comprises a base ( | 2011-02-03 |
20110027878 | RANDOM HOMOZYGOUS GENE PERTURBATION TO ENHANCE ANTIBODY PRODUCTION - The invention reflects enhanced antibody expression of an antibody of interest by cell lines transformed by random homozygous gene perturbation methods to either increase or decrease the expression pattern of a gene of the cell line other than the antibody of interest. The transformed cell line exhibits specific productivity rates, SPR, for the RHGP transformed cell liens of 1.5 or more, as compared with the antibody expressing cell line parents prior to transformation by RHGP. A knock out or anti-sense construct may be devised to reduce expression of the target gene, a promoter may be inserter to enhance expression of the target gene. The antibodies expressed by the transformed cell lines exhibit the binding properties of their parent cell lines prior to transformation with RHGP, and increase Total Volumetric Production of said antibody by said cells in a given volume. | 2011-02-03 |
20110027879 | Adipose-derived stem cells and lattices - The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures. | 2011-02-03 |
20110027880 | CELL CULTURE SYSTEM FOR PANCREATIC ISLANDS - Three-dimensional (3D) insulin-producing cell clusters derived from stem cells (preferably human embryonic stem cells) are provided by this invention, together with a method for their production using a microgravity bioreactor cell culture system. | 2011-02-03 |
20110027881 | PRODUCTION METHOD OF IMMUNE CELLS - A production method of T cells is disclosed which includes generating iPS cells from immune cells and differentiating the iPS cells into desired immune cells. In this method, 4 different genes Oct4, Sox2, Klf4 and c-Myc are introduced into immune cells for generation of iPS cells, and the iPS cells are then differentiated into immune cells by coculture with OP9 cells. Source immune cells are taken from a patient, and the produced desired immune cells are injected into the patient for medical treatment. | 2011-02-03 |
20110027882 | Methods and Compositions for Treating Neurological Disease - This invention relates to methods and compositions for treating neurological disease, and more particularly to methods of delivering iRNA agents to neural cells for the treatment of neurological diseases. | 2011-02-03 |
20110027883 | RNA INTERFERENCE MEDIATING SMALL RNA MOLECULES - Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a | 2011-02-03 |
20110027884 | COMBINATION OF INSULIN AND ASCORBATE TO ENHANCE WOUND HEALING - Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation. | 2011-02-03 |
20110027885 | SYSTEM AND METHOD FOR MICROMANIPULATING SAMPLES - A system and method for micromanipulating samples are described to perform automatic, reliable, and high-throughput sample microinjection of foreign genetic materials, proteins, and other molecules, as well as drawing genetic materials, proteins, and other molecules from the sample. The system and method overcome the problems inherent in traditional manual micromanipulation that is characterized by poor reproducibility, human fatigue, and low throughput. The present invention is particularly suited for adherent cell microinjection but can be readily extended to aspiration, isolation, and electrophysiological measurements of microorganisms, unicellular organisms, or cells. | 2011-02-03 |
20110027886 | METHOD OF INDUCING DIFFERENTIATION OF EMBRYONIC STEM CELLS INTO HEMANGIOBLAST - The present invention relates to a composition for inducing embryonic stem cell differentiation comprising a MEK/ERK (mitogen-activated protein kinase kinase/extracellular regulated kinase) signal transduction inhibitor and BMP (bone morphogenetic protein), and a method for inducing differentiation of embryonic stem cells into mesodermal cells using the same. Further, the mesodermal cells obtained by the above method are able to differentiate into various mesenchymal tissue cells. In particular, the present invention relates to a method for inducing differentiation into hemangioblast by culturing the mesodermal cells obtained by the above method in the presence of VEGF (vascular endothelial cell growth factor) and bFGF (basic fibroblast growth factor). The differentiated hemangioblasts can be further differentiated into vascular endothelial cells, vascular smooth muscle cells, and hematopoietic stem cells under various culture conditions. | 2011-02-03 |
20110027887 | METHOD OF DYNAMICALLY CULTURING EMBRYONIC STEM CELLS - The present invention is of a method of dynamically generating human embryoid bodies which can be used for generating lineage specific cells and cell lines. Specifically, the present invention can be used to generate ESC-differentiated cells for cell-replacement therapy. | 2011-02-03 |
20110027888 | Coated Fibers for Culturing Cells - A coated fiber for cell culture includes a fiber core having an exterior surface and a polymeric coating suitable for culturing cells disposed on at least a portion of the exterior surface of the fiber core. A polypeptide may be conjugated to the polymeric coating. A method for forming the coated fiber includes coating a polymer layer to an exterior surface of a fiber core to produce the coated fiber. The coating may occur as the fiber is being drawn. | 2011-02-03 |
20110027889 | Synthetic Microcarriers for Culturing Cells - A coated microcarrier for cell culture includes a microcarrier base and a polymeric coating grafted to the base via a polymerization initiator. A method for forming the coated microcarrier includes (i) conjugating a polymerization initiator to the microcarrier base to form an initiator-conjugated microcarrier base; (ii) contacting the initiator-conjugated microcarrier base with monomers; and (iii) activating the initiator to initiate polymerization and graft the polymer to the base. | 2011-02-03 |
20110027890 | MATERIAL FOR CELL CULTURE - A ligand construct containing at least two, identical or different, ligand molecules which are capable of binding to a cell surface receptor, the ligand molecules being coupled via a spacer, wherein the ligand construct has at least one functional group for binding substrates. According to the ligand construct of the present invention, the immobilization of the ligand construct to various artificial substrates is facilitated, so that an artificial matrix can be easily prepared on an optimal substrate, whereby cells can be stably cultured. | 2011-02-03 |
20110027891 | MAMMALIAN CELL CULTURE MEDIA WHICH COMPRISE SUPERNATANT FROM COHN FRACTIONATION STAGES AND USE THEREOF - The present invention relates to mammalian cell culture media which comprise supernatant from some of the fractions of human plasma fractionation according to the Cohn method, more specifically, the supernatant of fractions I and II+III. When said supernatant is added as a culture medium supplement it provides various nutrients and factors for the effective maintenance and/or proliferation of the cultured mammalian cells. In addition, the present invention relates to the preparation process and use of said medium in the culture of mammalian cells. | 2011-02-03 |
20110027892 | METHODS AND SYSTEMS FOR IDENTIFICATION, EXTRACTION, AND TRANSFER OF ANALYTICAL DATA FOR PROCESS CONTROL - Disclosed are methods, apparatuses, and systems, for (1) providing reliable identification of analytes from an HPLC or other analytical instrument, (2) ensuring data integrity during transfer of analytical data from the instrument to, for example, a control application or other destination, and (3) near-immediate transfer of the data after analysis. Embodiments include methods, apparatuses, and systems that automatically identify a subset of analytes from a plurality of analytes able to be analyzed by a liquid chromatograph (or similar instrument) and that automatically extract a subset of result data from the instrument, where the result data relates to a liquid mixture sample from a reactor (or other source) and where the subset of data corresponds to the subset of analytes. The subset of data may then be used to control a reactor process, or other process, by, for example, transferring the subset of data to a control application. | 2011-02-03 |
20110027893 | Method and apparatus for automated determining of chemical oxygen demand of a liquid sample - A method and apparatus for automated determining of the chemical oxygen demand of a liquid sample, comprising steps as follows: mixing the liquid sample with sulfuric acid; introducing a carrier gas, especially air, into the liquid sample-sulfuric acid mixture; adding an oxidizing agent to the liquid sample-sulfuric acid mixture to form a reaction mixture; heating (especially under reflux conditions) the reaction mixture at the boiling temperature of the reaction mixture for a predetermined time period; photometrically determining consumption of an oxidizing agent in the reaction mixture; and ascertaining therefrom the chemical oxygen demand of the liquid sample, wherein all steps are automatedly performed in an analytical system with the assistance of an evaluating and control unit. | 2011-02-03 |
20110027894 | BIOMARKERS FOR DETECTION OF EARLY- AND LATE-STAGE ENDOMETRIAL CANCER - Biomarker proteins that can be used in the diagnosis of early-stage endometrial cancer are described. Methods of screening for endometrial cancer, as well as methods of detecting and monitoring the status of endometrial cancer are provided. The biomarkers can be used to detect a variety of endometrial cancers, including endometroid carcinoma, clear cell carcinoma and serous carcinoma. | 2011-02-03 |
20110027895 | DETERMINATION METHOD OF MAGNESIUM CONTENT IN ALUMINIUM ALLOY - The present invention discloses a method for determination of magnesium content in aluminum alloy, including: dissolving an aluminum alloy sample, using one or more compounds selected from the group consisting of mercapto-containing compound, acetone cyanohydrin, β-aminoethyl mercaptan, triethanolamine, tetraethylenepentamine, ethylene diamine and oxydol as masking agent, using eriochrome black T or methyl thymol blue as indicator, and using EDTA or CDTA to titrate the sample. | 2011-02-03 |
20110027896 | CHROMOPHORE AND POLYMER CAPABLE OF DETECTING THE PRESENCE OF VARIOUS NEUROTOXINS AND METHOD OF USE - Applicants have produced a chromophore and a polymer that are highly sensitive to the presence of various agents, including organophosphates, pesticides, neurotoxins, metal ions, some explosives, and biological toxins. The detection is accomplished by detecting a change in the fluorescence characteristics of the chromophore or polymer when in the presence of the agent to be detected. The chromophore and polymer may be incorporated into sensors of various types, and they are adaptable for potential field use in areas where detection of these types of agents is desired. | 2011-02-03 |
20110027897 | Biomarker to Measure Drug Efficacy in Enteropathic Disease - The response of a patient with an enteropathic disease to therapy, particularly a candidate therapy in a clinical trial setting, is assessed by detecting the ability of the patient to metabolize an orally administered CYP3A substrate. The CYP3A metabolism may be monitored in a variety of ways. Conveniently, the appearance of a metabolite of the CYP3A substrate is detected in a patient sample over a period of time following oral administration, e.g. in urine, plasma, breath, saliva, etc. The CYP3A substrate is optionally labeled, e.g. with an isotopic, fluorescent, etc. label. | 2011-02-03 |
20110027898 | METHODS AND ARTICLES FOR STRAND-SPECIFIC POLYNUCLEOTIDE DETECTION WITH CONJUGATED POLYMERS - The invention further relates to conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. In some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein. | 2011-02-03 |
20110027899 | HAZARDOUS CHEMICALS DETECTOR & METHODS OF USE THEREOF - Embodiments of the invention are directed to an apparatus and method for detecting explosive compounds by air sampling followed by subjecting the air sample to a detection method. In one embodiment, a test area is sampled by drawing air from the vicinity of the test area, heating or irradiating the air sample and subjecting the irradiated sample to a detection method. With respect to nitrogen-containing explosive compounds, heating or irradiating the air sample produces nitrogen dioxide (NO | 2011-02-03 |
20110027900 | Thiol quantitation assays and related methods - The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair. | 2011-02-03 |
20110027901 | METHODS AND DEVICES FOR DETECTING THE PRESENCE OF AN ANALYTE IN A SAMPLE - Sensor assay methods for detecting the presence of an analyte in a sample are provided. Aspects of the methods include providing a sensor, e.g., a proximity sensor, in contact with an assay composition that includes a sample and a proximity label. Next, a capture probe configured to bind to the proximity label and the analyte is introduced into the assay composition to produce a labeled analyte. Following capture probe introduction, a signal is obtained from the sensor to detect the presence of the labeled analyte in the sample. Also provided are sensor devices, including hand-held devices, and kits that find use in practicing the subject methods. | 2011-02-03 |
20110027902 | STRUCTURE FOR INTRODUCING A PLURALITY OF SOLUTIONS, MICRO FLUIDIC DEVICE HAVING SAID STRUCTURE AND METHOD FOR INTRODUCING SOLUTION - The present invention relates to a structure (a solution introducing structure) for introducing a plurality of solutions (a sample and/or a reagent solution) in highly accurate volume, in high amount and simply, into a channel, in particular a channel of a micro fluidic device, a micro fluidic device having said structure, a method for introducing a solution using said device, a method for separation of a substance, and a method for separating a complex between an analyte or analogue thereof, and a substance binding to said analyte or analogue thereof (hereinafter may be abbreviated as a complex forming substance or CFS) which is obtained by reacting a plurality of solutions introduced by these, and said CFS or analogue not involved in formation of said complex, rapidly, simply and in high accuracy, along with a method for measuring an analyte or an analogue thereof in a sample in high sensitivity. | 2011-02-03 |
20110027903 | FECAL SAMPLING DEVICE AND METHOD - A specimen sampling device having a first panel including multiple apertures (e.g., a first, second and third aperture) for receiving samples; a second panel having a removable tab at least partially aligned with the first, second and third apertures for receiving the samples, the removable tab accessible from an exterior of the device. A method of obtaining a fecal sample is also disclosed. | 2011-02-03 |
20110027904 | SAMPLE MIXING ON A MICROFLUIDIC DEVICE - Mixing structures for use on sample processing devices are disclosed. The mixing structures include one or more mixing chambers in fluid communication with a process chamber, such that changing the rotational speed of the sample processing device forces sample material into and out of the mixing chamber to achieve mixing of the sample material. The mixing chambers are in fluid communication with the process chambers through mixing ports that are located on the distal sides of the process chambers with respect to the axis about which the sample processing device is rotated. | 2011-02-03 |
20110027905 | Systems and Methods for Collection and Analysis of Analytes - Systems and methods are provided for collecting and analyzing analytes. One embodiment of the invention includes a system for collecting analyte. The system comprises a sampling section disposed on a collection platform and an air source that provides an analyte to be sorbed by the sampling section. The sampling section can be formed of a low pressure drop configuration of sorbent material | 2011-02-03 |
20110027906 | METERING DOSES OF SAMPLE LIQUIDS - A device and method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture. | 2011-02-03 |
20110027907 | SSL7 MUTANTS AND USES THEREFOR - The invention relates to SSL7 mutants which have no, or at least reduced, ability to bind to IgA. The mutants have significant application in the purification or isolation of C5 from samples and in the identification or detection, including quantitation, of C5 in samples. Use of the mutants has the benefit of minimising or preventing simultaneous isolation and/or detection of IgA in a sample, simplifying and improving methods relying on wild type SSL7. | 2011-02-03 |
20110027908 | DEVICE FOR DETECTION OF ANTIGENS AND USES THEREOF - Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed. | 2011-02-03 |
20110027909 | Chimera Compositions and Methods of Use - This invention is directed to novel compositions, process methods, research tools, and use of these in the identification and development of novel therapeutic and/or diagnostic products. The compositions of the invention are chimera proteins that in essence recreate and/or potentiate one or more protein complex interactions that occur in vivo in the modulation of biological processes. | 2011-02-03 |
20110027910 | SCREENING - A method of producing a conformational specific binding partner of a GPCR, the method comprising: a) providing a mutant GPCR of a parent GPCR, wherein the mutant GPCR has increased stability in a particular conformation relative to the parent GPCR; b) providing a test compound; c) determining whether the test compound binds to the mutant GPCR when residing in a particular conformation; and d) isolating a test compound that binds to the mutant GPCR when residing in the particular conformation. Methods of producing GPCRs with increased stability relative to a parent GPCR are also disclosed. | 2011-02-03 |
20110027911 | SOLUBILIZATION AND STUDY OF MEMBRANE PROTEINS - Provided are methods for solubilizing a membrane protein in order to provide substantially homogeneous membrane proteins that are solubilized within reverse micelle systems at concentrations that are suitable for analytical study of such membrane proteins, including nuclear magnetic resonance spectroscopy. Also provided are substantially homogeneous membrane proteins that are solubilized within a reverse micelle system, as well as methods for the study of solubilized membrane proteins, and for the screening of drug candidates that target such membrane proteins. | 2011-02-03 |
20110027912 | PURIFIED SERUM ALBUMIN, AND IMMUNOLOGICAL MEASUREMENT METHOD - An object of the present invention is to provide: a purified serum albumin having less lot-to-lot variation; and an immunoassay method utilizing the purified serum albumin, in which high reactivity and less non-specific reactions are achieved. | 2011-02-03 |
20110027913 | MULTIPLEXED NANOSCALE ELECTROCHEMICAL SENSORS FOR MULTI-ANALYTE DETECTION - Provided are nanoscale devices suitable for multiplexed, parallel detection of multiple analytes and methods for fabricating such devices. | 2011-02-03 |
20110027914 | SAMPLE PLATE SYSTEMS AND METHODS - A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate. | 2011-02-03 |
20110027915 | METHOD OF PRODUCING INSOLUBLE CARRIER PARTICLES, INSOLUBLE CARRIER PARTICLES, MEASUREMENT REAGENT, SPECIMEN ANALYZING TOOL, AND IMMUNOTURBIDIMETRIC ASSAY - The present invention provides a measurement reagent that is capable of suppressing nonspecific aggregation even when the amount of antibody to be carried is increased, and is capable of measuring in a wide measurement concentration range with high measurement sensitivity; an immunoturbidimetric assay using the same; and a method of producing thereof. A method of producing an insoluble carrier particle of the present invention is a method of producing an insoluble carrier particle carrying an antibody or an antigen on a particle surface thereof. The method includes a sensitization reaction processes in which the antibody or the antigen is brought into contact with the insoluble carrier particle in the presence of an amino acid with a charged polar side chain in a sensitization reaction solution. The insoluble carrier particles obtained by the producing method of the present invention show favorable dispersibility because nonspecific aggregation is suppressed. As can be seen from Examples 1-1 to 1-4 in FIG. | 2011-02-03 |