06th week of 2011 patent applcation highlights part 38 |
Patent application number | Title | Published |
20110033821 | Rotatable Endodontic Instruments and Methods for their Manufacture - A quasi-hyperbolic endodontic instrument having a cylindrical, elongated shaft with a radius that varies as a smooth, continuous curve along the length of the shaft and is larger near the distal portion of the file than near the proximal end of the file. The distal radius may be 10% or more larger than the proximal radius. This design provides a flexible file that minimizes the possibility of breaking, and ensures that if breakage does occur, it will occur near the handle, allowing the broken bit to be easily removed from the tooth canal. The instrument may further, or instead, have a metal cable connecting the cutting head to the handle to help reduce metal fatigue. | 2011-02-10 |
20110033822 | Endodontic File - An endodontic instrument eliminates the need for conventional flutes by employing a tapered tip having an axially extending relief surface such as a flat permitting the passage of liquid and the ejection of debris from the tooth. In one embodiment, an abrasive surface of the tapered tip is produced by electrical discharge machining which provides randomly arrayed microscopic pits directly in the metallic surface of the instrument. | 2011-02-10 |
20110033823 | ROTATABLE ULTRASONIC DENTAL TOOL - The present invention describes an ultrasonic dental insert capable of enhanced operating efficiency. A first transducer generates ultrasonic vibrations. A connecting body has a proximal end and a distal end having a tip attached thereto. The proximal end is attached to the first transducer so as to receive the ultrasonic vibrations therefrom and to transmit the ultrasonic vibrations toward the tip attached to the distal end. The ultrasonic dental insert may be inserted into a handpiece for providing electromagnetic energy to the first transducer to generate the ultrasonic vibrations. The ultrasonic insert, when seated in the handpiece, is substantially decoupled, on a rotary axis, from the handpiece. A rotary force need only be applied to the insert to rotate it in the handpiece. At least one light source substantially proximate or distal to the tip may also be provided. | 2011-02-10 |
20110033824 | USE OF SERICIN FOR IMPROVING THE FEELING IN USE OF DENTURE - The purpose is to prevent, ameliorate or relieve various conditions induced in the dried oral cavity or to improve the stability of a denture during use. A solution for treating a denture or a denture stabilizer comprising sericin can be used. | 2011-02-10 |
20110033825 | DENTAL IMPLANT - A dental implant system for supporting a cosmetic tooth prosthesis includes an elongated body adapted to be disposed in a jaw bone of a patient. The elongated body includes a distal end and a proximal end and extends along a longitudinal axis. The elongated body includes a tapered outer surface that tapers along the longitudinal axis distally from the proximal end of the elongated body. The outer surface of the tapered elongated body includes a plurality of barbs for securing the elongated body in the jaw bone of the patient. | 2011-02-10 |
20110033826 | IMPLANT ROOT FOR TOOTH IMPLANTING - An improved implant root for tooth implanting, a coarse threaded portion of the implant root is formed to have at least two helical treated surfaces extending from the bottom to the top of the implant root of the coarse threaded portion each being treated with a roughened coating (for example, covered with a hydroxyapatite coating) and extending in the whole length of the coarse threaded portion and each extending in the vertical direction. The areas of the roughened coatings can thus be increased in favor of fast growth of a bone of a denture base after implanting into the bone to envelop the implant root; this can shorten the curing process from implanting the implant root to mounting a crown. | 2011-02-10 |
20110033827 | Method of using dental material and composite dental material formed by using hydroxyapatite - A dental material formed by using a hydroxyapatite, which is suitable for performing a guided bone regeneration (GBR) method in the implant therapy of dentistry. Also, a composite dental material which is a bioabsorbable film provided integrally with hydroxyapatite is capable of rapidly attracting osteoblast and blocking fibroblast. The dental material is a membrane for a guided bone regeneration method of guiding a bone formation by preventing invasion by anaplastic fibroblast by covering a bone developing site with a blocking membrane and filling the bone developing site with osteoblast, wherein a main body of the blocking membrane is formed by using hydroxyapatite having osteoconductive capability of rapidly attracting osteoblast for the purpose of disposing the hydroxyapatite at a bone developing site side of the membrane main body. | 2011-02-10 |
20110033828 | DENTAL POST AND METHOD FOR ITS FABRICATION - A dental post consisting of fibre-reinforced material with substantially uniformly directed fibers and mountable in a tooth root canal for fixing a dental prosthetic structure on a tooth stump and a method for its fabrication. | 2011-02-10 |
20110033829 | Evaluation and Assessment System - An evaluation system for detecting an anomalous response to a particular question from a plurality of questions is described. For each of the plurality of questions, data relating to a score, a trainee's confidence level in his response, and the elapsed time are stored. An anomaly processor processes the score, confidence level and elapsed time data for a set of questions taken from the plurality of questions. An output is produced indicating whether or not an anomalous response to a particular question is detected, which can be used by a computerised training system to determine whether or not the trainee passes the assessment. | 2011-02-10 |
20110033830 | CTS PEP PREVENTION EDUCATIONAL PRODUCTS - Carpal Tunnel Syndrome (CTS) and Cumulative Trauma Disorders (CTD's, also known by other names such as repetitive stress injuries [RSI's] and other such names, have emerged as a significant occupational health problem. The present invention is to provide systems, devices, products, methods and software programs, which will remind individuals, such as keyboard operators, on a regularly scheduled basis, and to recommend certain preventive exercises and the like. Once the system and the software is designed and implemented, a study will then be instituted to measure its effectiveness in workplaces, especially those that have experienced a high incidence of problems such as carpal tunnel syndrome. The recommendations for specific actions, such as posture and exercises, will be based on work already established in the medical and occupational literature and journals, as well as the continuous research conducted by medical experts in the field. The development of a relatively inexpensive method of controlling, reducing and preventing the incidence of these disorders is important to prevent injuries and to save money on insurance premiums, payments to injured workers, loss of productivity, loss of productive workers from the workplace as well as the need to retrain injured workers. Furthermore, the invention relates to an electronic device or chip that would act as the heart of the above system, and could be used as an embedded chip in various products. | 2011-02-10 |
20110033831 | METHOD AND APPLIANCE FOR DISTRACTION FROM AN UNWANTED IMPULSE - Apparatus for distracting a user from an unwanted impulse, such as an impulse to eat, having an elastic bracelet to be stretched and then released at once upon feeling the unwanted impulse by the user, thereby snapping the user, resulting in causing pain to the user, thereby distracting the user from the impulse. The stretching may be carried out each time to the same level. The level may be indicated by an indicator capable of registering only a certain stretching level of the bracelet. The stretching may be to any desired level. The stretching level may be determined using a gauge. | 2011-02-10 |
20110033832 | ADMINISTRATION INSTRUMENT FOR MEDICAL USE - The present invention relates to an administration instrument for medical use that can perform injection of a drug solution with stability and with great reliability. For example, at the administration, it is possible to prevent a force that presses the injection button from acting in a direction of inserting the needle that is inserted into the skin deeper, and enables the administration under a stable state where the needle does not wobble, thereby alleviating physical and mental pain of the administration patient. | 2011-02-10 |
20110033833 | PUMP WITH THERAPY COACHING - An apparatus comprising a pump, an input configured to receive information related to a user, a user interface, and a controller communicatively coupled to the pump, the input, and the user interface. The controller includes a timing module configured to initiate delivery of a drug in time and to adjust delivery according to the received information. Other devices, systems, and methods are disclosed. | 2011-02-10 |
20110033834 | ETEACHER - ELECTRONIC TEACHER FOR CONVEYING COMPLEX CONTENT FOR LEARNING - Embodiments provide methods, devices, and programs that simulate a teacher who teaches a complex program system to a student in private lessons. Embodiments may further provide customized feedback and reinforcement to students. Teaching units and action trees for learning are also discussed. | 2011-02-10 |
20110033835 | TRAINING DEVICE - A training device capable of converting kinetic energy of an agent into electric energy while applying to the agent a resistance force of a variation behavior appropriate to a motion behavior of the agent. According to the training device, a strength and a direction of a resistance force applied to the agent can be varied via a regenerative braking on a motor according to at least one of a variation behavior of a relative posture between an upper body and a leg of the agent and a temporal variation behavior of the relative posture therebetween. | 2011-02-10 |
20110033836 | METHODS FOR DETERMINING THE PRESENCE OF ANTIBODIES BLOCKING VIRAL INFECTION - The present invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient infected by the virus; (b) co-transfecting into a first cell (i) the nucleic acid of step (a), and (ii) a viral expression vector which lacks a nucleic acid encoding an envelope protein, and which comprises an indicator nucleic acid which produces a detectable signal, such that the first cell produces viral particles comprising the envelope protein encoded by the nucleic acid obtained from the patient; (c) contacting the viral particles produced in step (b) with a second cell in the presence of the compound, wherein the second cell expresses a cell surface receptor to which the virus binds; (d) measuring the amount of signal produced by the second cell in order to determine the infectivity of the viral particles; and (e) comparing the amount of signal measured in step (d) with the amount of signal produced in the absence of the compound, wherein a reduced amount of signal measured in the presence of the compound indicates that the compound inhibits entry of the virus into the second cell. | 2011-02-10 |
20110033837 | IMMORTALIZED HUMAN CD4-POSITIVE CELL AND ITS USE FOR DETERMINING THE PHENOTYPE OF A HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 - The invention relates to an immortalized CD4-positive cell. According to the invention, this cell comprises a gene encoding a CXCR4 chemokine receptor that is capable of serving as a coreceptor for entry of a Human Immunodeficiency Virus Type 1 (HIV-I) into the cell, and a gene encoding a CCR5 receptor that is not capable of serving as a coreceptor for entry of a Human Immunodeficiency Virus Type 1 into the cell. The invention furthermore relates to a method for the phenotypical characterization of a HIV-I, comprising providing such a cell, adding an HIV-I to the cell under conditions that allow for the entrance of the HIV-I into the cell and the replication of the virus in the cell, and measuring the replication of the HIV-I in the cell. | 2011-02-10 |
20110033838 | SURFACE ANTIGEN PROTEIN MUTANT OF HEPATITIS B VIRUS SURFACE ANTIGEN - The disclosure relates, in some embodiments, to sequences of a novel mutant or variant of the hepatitis B surface antigen (HBsAg) and methods for detecting this genome and protein variant, and antibodies directed against it, from patients' samples. | 2011-02-10 |
20110033839 | Methods of Detecting Signatures of Disease or Conditions in Bodily Fluids - Methods and compositions for diagnosing the presence of a cancer cell in an individual are provided. Methods and compositions for identifying a tumor-specific signature in an individual having cancer are also provided. Methods and compositions for diagnosing the presence of an infectious agent in an individual and/or for identifying an infectious agent-specific signature in an infected individual are provided. Methods and compositions for diagnosing the presence of a disease in an individual are also provided. Methods and compositions for identifying a disease-specific signature in an individual having the disease are also provided. | 2011-02-10 |
20110033840 | VIRAL DETECTION LIPOSOMES AND METHOD - A method of generating pathogen detecting liposomes includes a step of providing molecular beacons with fluorescing components. The molecular beacons include either strands of RNA or DNA and the fluorescing components include an emitter and a quencher. The method further uses nanodroplet technology to encapsulate the molecular beacons within a lipid membrane. Subsequently, receptors are assembled in association with the membrane. | 2011-02-10 |
20110033841 | METHODS AND KITS FOR DIAGNOSIS, PROGNOSIS OR MONITORING OF EPSTEIN-BARR VIRUS (EBV)-ASSOCIATED CANCER - Disclosed is a non-invasive method for diagnosis, prognosis or monitoring of Epstein-Barr virus (EBV)-associated cancer by detecting and/or quantifying EBV associated nucleic acid fragments in a urine sample from an individual. Kits for diagnosis, prognosis or monitoring of cancer are also disclosed. | 2011-02-10 |
20110033842 | Skin Sampling Kit Which Stores Nucleic Acids In Stable Status, Genetic Test Methods By Using The Kit And Their Practical Application - The present invention relates to a new skin gene card for genetic test, a method for acquiring DNA and RNA and performing various genetic tests using the same, and practical applications thereof. More specifically, the inventors of the present invention have developed a skin gene card capable of acquiring samples from human skin, hair or mucosa simply, safely and quickly and enabling stable long-term storage and transport of DNA and RNA included in the acquired sample at room temperature. Various genetic tests may performed using the acquired DNA and RNA, including polymerase chain reaction (PCR), reverse transcription (RT)-PCR, real-time PCR, sequencing, hybridization, DNA chip analysis, single-nucleotide polymorphism (SNP) assay, gene mutation assay, promoter methylation assay, gene expression assay, etc. The genetic skin test result may be utilized for disease prognosis, nutrigenomic test, pharmacogenomic test, forensic test such as personal identification, diagnosis of genetic diseases, diagnosis of skin diseases, or the like. In addition, through an objective evaluation of the skin or hair condition, a personalized cosmetic and skin care system may be established for practical application in beauty care, cosmetology, dermatology, and clinical practice. | 2011-02-10 |
20110033843 | METHOD FOR IN VITRO TESTING OF COMPOUNDS FOR ASSESSING THERAPEUTIC VALUE IN THE TREATMENT OF MULTIPLE SCLEROSIS AND OTHER DISEASES WHEREIN FOAMY CELLS ARE INVOLVED IN THE DISEASE ETIOLOGY - The invention provides a method for assessing or determining activity of a test Compound on modulation of gene product levels comprising culturing cells, contacting at least one of the cultured cells with a lipid-rich fraction, contacting at least one of the cultured cells with the test Compound, determining the presence of a gene product of at least one cell of the cultured cells and, optionally, determining the presence of the gene product of at least one cultured cell not contacted with the test Compound. To assess human conditions most fully, it is preferred that the cell is of human origin, for example, a peripheral blood monocyte taken from a healthy donor. | 2011-02-10 |
20110033844 | USE OF LYSOSOMAL CARBOXYPEPTIDASE C (PRCP) AS A THERAPEUTIC OR DIAGNOSTIC TARGET - The invention provides a human PRCP which is associated with the cardiovascular diseases, hematological diseases, neurological diseases and cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases and cancer. The invention also features compounds which bind to and/or activate or inhibit the activity of PRCP as well as pharmaceutical compositions comprising such compounds. | 2011-02-10 |
20110033845 | Methods For Amplification of Nucleic Acids Using Spanning Primers - The teachings relate to methods and kits for detecting whether target nucleic acid sequences are present and/or quantitating target nucleic acid sequences. | 2011-02-10 |
20110033846 | Concurrent Analysis of Multiple Patient Samples Using Solid Phase Addressable Multiplex Test with High Signal-to-Noise Ratio - Contemplated systems and methods allow analysis of multiple and distinct patient samples using a labeling scheme that entirely avoids carry-over of a label or reagent to the analytic platform, typically an addressable solid phase. In preferred aspects, a hybridization portion, a fluorophore, and/or a quencher are removed by a 5′-3′-exonuclease activity of a polymerase from a reporter oligonucleotide to so remove the oligonucleotide from the pool of molecules that bind to the solid phase and/or or to provide signal differentiation by removal of a fluorophore or quencher. | 2011-02-10 |
20110033847 | Methods for the characterization of microorganisms on solid or semi-solid media - The present invention relates to methods and systems for scanning, detecting, and monitoring microorganisms on solid or semi-solid media using intrinsic fluorescence (IF) measurements. The methods are further directed to detection, characterization and/or identification of microorganisms on a solid or semi-solid media using intrinsic fluorescence (IF) measurements that are characteristic of said microorganisms. | 2011-02-10 |
20110033848 | EPIGENETIC METHODS - The present invention provides methods for obtaining epigenetic information for a polyploid subject, the method including the steps of obtaining a biological sample from the subject, the sample containing: (i) at least one paternally-derived DNA molecule and/or associated protein and/or, (ii) at least one maternally-derived DNA molecule and/or associated protein, analyzing any one or more of the paternally- or maternally-derived DNA molecules or associated proteins for the presence or absence of modifications, wherein the step of analyzing determines whether any two modifications are present in cis on one chromosome, or in trans across two sister chromosomes. | 2011-02-10 |
20110033849 | OVINE IDENTIFICATION METHOD - The invention relates to method for identifying an ovine with a genotype indicative of one or more altered performance traits, the method including the step of detecting, in a sample derived from the ovine, the presence of at least one allele of the CP34 simple sequence repeat (SSR) marker, or at least one allele of a marker in linkage disequilibrium (LD) with CP34, wherein the presence of the allele is indicative of the altered performance traits in the ovine. | 2011-02-10 |
20110033850 | COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION - Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed. The methods involve forming a mixture comprising a linear sequence of a tRNA anticodon stem loop fragment that is not capable of forming a stem-loop, a target nucleic acid molecule capable of binding to the tRNA anticodon stem loop fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule. | 2011-02-10 |
20110033851 | NUCLEIC ACID AMPLIFICATION - Provided herein is a method for the selective amplification of a target nucleotide sequence located within a nucleic acid molecule, the method comprising contacting the nucleic acid molecule (“template” molecule) with (i) at least one facilitator oligonucleotide, wherein the facilitator oligonucleotide includes at least one modification at or near its 3′ terminus such that 3′ extension from the facilitator oligonucleotide is blocked, and (ii) two or more oligonucleotide primers, at least one of which is an initiator primer modified such that the presence of the modification prematurely terminates complementary strand synthesis, wherein the facilitator oligonucleotide and the initiator primer bind to substantially the same or adjacent regions of the template nucleic acid molecule and the facilitator oligonucleotide further comprises sequences complementary to the target sequence 3′ to the binding location of the initiator primer; and carrying out thermocyclic, enzymatic amplification such that the specific target sequence is selectively amplified. | 2011-02-10 |
20110033852 | PRESENT INVENTION RELATES TO METHODS FOR PREDICTION OF THE THERAPEUTIC SUCCESS OF BREAST CANCER THERAPY - The present invention relates to a method for predicting a clinical response of a patient suffering from or at risk of developing gynecologic cancer towards a given mode of treatment, said method comprising the steps of: a) obtaining a biological sample from said patient; b) determining the expression level of at least one gene selected from the group comprising ALCAM, Osteopontin, Her-2/neu, EGFR, uPA/PAI-1 and/or ESR1, in particular of ALCAM and/or Osteopontin, in said sample; c) comparing the pattern of expression level (s) determined in (b) with one or several reference pattern (s) of expression levels; and d) predicting therapeutic success for said given mode of treatment in said patient or implementing therapeutic regimen in said patient from the outcome of the comparison in step (c). | 2011-02-10 |
20110033853 | CSNKS As Modifiers of the RAC Pathway and Methods of Use - Human CSNK genes are identified as modulators of the RAC pathway, and thus are therapeutic targets for disorders associated with defective RAC function. Methods for identifying modulators of RAC, comprising screening for agents that modulate the activity of CSNK are provided. | 2011-02-10 |
20110033854 | METHODS AND COMPOSITIONS FOR LONG FRAGMENT READ SEQUENCING - The present invention is directed to methods and compositions for long fragment read sequencing. The present invention encompasses methods and compositions for preparing long fragments of genomic DNA, for processing genomic DNA for long fragment read sequencing methods, as well as software and algorithms for processing and analyzing sequence data. | 2011-02-10 |
20110033855 | METHOD FOR QUANTIFYING TARGET NUCLEIC ACID MOLECULES AND KIT FOR QUANTIFYING TARGET NUCLEIC ACID MOLECULES - The present invention is to provide a method for highly sensitively and precisely quantifying nucleic acid molecules in a sample. The method for quantifying target nucleic acid molecules in a nucleic acid-containing sample comprises: (a) preparing a sample solution comprising a nucleic acid-containing sample, a first nucleic acid molecule probe comprising a sequence complementary to the target nucleic acid molecule and conjugated with a first marker, and a second nucleic acid molecule probe comprising a sequence complementary to the first nucleic acid molecule probe and conjugated with a second marker; (b) denaturing nucleic acid molecules in this sample solution; (c) hybridizing them; (d) forming a covalent bond between two nucleic acid strands in the hybrid under a same condition, regarding the temperature and the salt concentration, as that of the hybrid formation; and (e) quantifying the target nucleic acid molecules by detecting a time course change in an optical characteristic of the first marker or the second marker in the sample solution, wherein an optical characteristic of at least either one of the first marker and the second marker is changed depending on whether or not the first nucleic acid molecule probe and the second nucleic acid molecule probe are hybridized. | 2011-02-10 |
20110033856 | METHODS RELATING TO AROMATASE INHIBITOR PHARMACOGENETICS - Methods for aiding in determining therapeutic efficacy of an aromatase inhibitor in a subject are provided according to embodiments of the present invention which include detecting expression and/or function of at least one UDP-glucuronosyltransferase having activity to modify at least one aromatase inhibitor and/or metabolite of the aromatase inhibitor by glucuronidation, wherein detection of expression and/or function of the UDP-glucuronosyltransferase is correlated with therapeutic efficacy of the aromatase inhibitor in the subject. Detection of UDP-glucuronosyltransferase expression and/or function includes detection of a UDP-glucuronosyltransferase gene deletion polymorphism in the subject | 2011-02-10 |
20110033857 | PEPTIDE SEQUENCE THAT PROMOTES TUMER INVASION - An isolated sequence SGSSEEKQNAVSSEET (OPNcPEP) SEQ ID NO: | 2011-02-10 |
20110033858 | siRNA DETECTION METHOD - PolydG is added to the terminal overhangs of an siRNA. Next, a primer containing a polydC sequence added with a tag sequence is annealed and cDNA is synthesized by a reverse transcription reaction. Quantitative PCR is performed between a primer carrying the same sequence as the tag sequence, and a primer containing the same sequence as the siRNA sequence to be detected. The amount of siRNA of interest can be determined from a calibration curve produced using known amounts of short-chain dsDNA. | 2011-02-10 |
20110033859 | RNAi INHIBITION OF INFLUENZA VIRUS REPLICATION - The invention relates to compositions and methods for modulating the expression of influenza viral genes, and more particularly to the downregulation of influenza viral genes by chemically modified oligonucleotides. | 2011-02-10 |
20110033860 | Method For Searching Target Base Sequence Of Rna Interference, Method For Designing Base Sequence Of Polynucleotide For Causing Rna Interference, Method For Producing Double-Stranded Polynucleotide, Method For Inhibiting Gene Expression, Base Sequence Processing Apparatus, Program For Running Base Sequence Processing Method On Computer, Recording Medium, And Base Sequence Processing System - In the present invention, a sequence segment conforming to the following rules (a) to (d) is searched from the base sequences of a target gene of RNA interference and, based on the search results, siRNA capable of causing RNAi is designed, synthesized:
| 2011-02-10 |
20110033861 | METHOD FOR DIAGNOSING SPINAL MUSCULAR ATROPHY - A method for diagnosing spinal muscular atrophy is provided. The method includes providing a biological sample of a subject containing a nucleotide of SMN gene, amplifying SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a universal multiplex PCR using the nucleotide as a template and the primers to obtain fragments of the SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8, labeling the fragments of the SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a fluorescent primer to obtain fluorescence-labeled exon fragments, and analyzing the fluorescence-labeled exon fragments by a capillary electrophoresis. If the SMN1/SMN2 ratios in exon 7 and 8 are different, it indicates that the subject is susceptible to spinal muscular atrophy. Additionally, if the peak of certain exon fragment appears crossed, it indicates an intragenic mutation in the exon. | 2011-02-10 |
20110033862 | METHODS FOR CELL GENOTYPING - Methods for cell genotyping are disclosed herein. A method for determining the genomic data of one or a small number of cells, or from fragmentary DNA, where a limited quantity of genetic data is available may include adding one or more targeted primers to a whole genome amplification of a cell, increasing the accuracy with which key alleles are measured in the context of a whole genome amplification. The genetic material from a single cell may be divided into fractions, each of which may be separately genotyped, allowing the reconstruction of the cells haplotype. The genetic material from a single cell may be divided into fractions, each of which may be separately genotyped, and the distribution of the various alleles in the different fractions may be used to determine the ploidy state of one or a plurality of chromosomes in the cell. | 2011-02-10 |
20110033863 | RNA-SELECTIVE HYBRIDIZATION REAGENT AND USE OF THE SAME - Provided is a nucleoside derivative which has a high affinity for RNA. Use is made of a nucleoside derivative represented by either formula (1) or formula (2). (In formulae (1) and (2), Z represents a carbon atom or a nitrogen atom; R | 2011-02-10 |
20110033864 | PROLIFERATIVE DISEASE DETECTION METHOD - In the present invention, the methylation of the genomic DNA a Zar1 gene specifically found in proliferative disease is used as a marker. Specifically, the present invention provides a method for detecting proliferative disease, which comprises detecting the methylation of the genomic DNA of a Zar1 gene in a biological sample. There is thereby provided a method for detecting proliferative disease, using a marker having a high detection rate and a low false positive rate. | 2011-02-10 |
20110033865 | NOVEL METHOD FOR DIAGNOSING PREGNANCY-RELATED COMPLICATIONS - A method for diagnosing pregnancy-related complications in a pregnant woman is provided. The method includes the following steps: (a) determining the level of Placental Protein 17 (PP17) in a bodily substance obtained from the pregnant woman; and (b) comparing the determined level of PP17 to a standard level of PP17, a significant modification in the level of PP17 indicating the existence of a pregnancy-related complication in the pregnant woman. A diagnostic kit is also described. | 2011-02-10 |
20110033866 | Resonance Energy Transfer Assay with Cleavage Sequence and Spacer - A molecular construct comprises a donor label, an acceptor label, a linker peptide disposed between the donor and the acceptor, the linker having a cleavage site sequence, and a spacer between at least one of (a) the donor and the cleavage site sequence and (b) the acceptor and the cleavage site sequence. Preferably, the construct is selected from the group consisting of CFP-(SGLRSRA)-SNAP-25-(SNS)-YFP, and CFP-(SGLRSRA)-synaptobrevin-(SNS)-YFP. In preferred embodiments, the linker peptide is a substrate of a botulinum neurotoxin selected from the group consisting of synaptobrevin (VAMP), syntaxin and SNAP-25, or a fragment thereof that can be recognized and cleaved by the botulinum neurotoxin. Advantageously, the spacer increases the electronic coupling between the donor label and the acceptor label relative to a corresponding construct without the spacer. | 2011-02-10 |
20110033867 | Use of biomarkers for detecting ovarian cancer - The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject. | 2011-02-10 |
20110033868 | USE OF A NITRATED PROTEIN OR PEPTIDE SEQUENCE FOR THE IMPLEMENTATION OF A METHOD OF DIAGNOSIS - The present invention relates to the use of quantitative assay, in particular in vitro, in a biological sample, of the degree of nitration of tyrosine residues of a particular nitrated protein or physiological peptide sequence, for the implementation of a method of in vitro diagnosis of the state of severity and progressiveness of a chronic or acute pathology associated with nitrating stress. | 2011-02-10 |
20110033869 | Enzyme Triggered Redox Altering Chemical Elimination (E-Trace) Immunoassay - The present invention is directed to electronic methods of detecting target analytes such that upon binding of the target analyte a shift in electrochemical potential is seen. This assay relies on the use of an electroactive moiety (“EAM”) that is attached to an electrode and comprises a self-immolative moiety, whose presence gives the EAM a first E0, and whose absence, upon irreversible cleavage gives the EAM a second E0. This difference is detected, and if such change occurs, it is an indication of the presence of a target analyte. | 2011-02-10 |
20110033870 | HYBRIDOMA PRODUCING ANTIBODIES TO LAWSONIA INTRACELLULARIS - The present invention relates to the field of animal health and in particular to | 2011-02-10 |
20110033871 | METHOD FOR THE DETERMINATION OF TRICHINELLA INFECTIONS AND DIAGNOSTIC COMPOSITION FOR SUCH METHODS - Method for the determination of | 2011-02-10 |
20110033872 | METHOD AND APPARATUS FOR DETECTING UNDESIRED MEASUREMENT CONDITIONS - The invention relates to a method and apparatus for detecting undesired measurement conditions in a sample container. The method comprises measuring a fluorescent property of the sample container comprising a sample substrate with impregnated blood sample and incubation buffer to which the blood sample is to be eluted, and determining, based on temporal and/or spectral characteristics of the fluorescent property, whether the fluorescent property is characteristic to a sample container comprising a sample substrate and incubation buffer under said undesired measurement conditions or to a sample container suitable for optical measurement of analyte contained in the sample. Thus undesired measurement condition can be a floating sample substrate or a foreign body in the sample container. By means of the invention, reliability of neonatal screening, for example, can be increased. | 2011-02-10 |
20110033873 | PROTEINIC MARKER FOR EARLY DIAGNOSIS OF LIVER CANCER - The present invention relates to proteomic markers for early detection of hepatocellular carcinoma, compositions for detecting changes of these proteomic markers, kits for detection of hepatocellular carcinoma, methods for detecting proteomic markers including these compositions, methods for screening drugs for hepatocellular carcinoma using these proteomic markers, and antibodies specific for these proteomic markers. | 2011-02-10 |
20110033874 | BIOMARKERS - The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac transplant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by measuring ANP signal peptide levels in a sample taken from a subject shortly after onset of, or presentation with the disorder or transplant rejection. Also provided are antibodies useful in the methods of the invention. | 2011-02-10 |
20110033875 | GLYCOPROTEIN CANCER BIOMARKER - The invention relates to glycoproteins having a cancer-specific glycoform. Cancer-specific glycoforms are useful in diagnostics and therapeutics. | 2011-02-10 |
20110033876 | METHOD FOR DIAGNOSING PULMONARY ARTERY HYPERTENSION - The invention relates to an in vitro method for detecting pulmonary arterial hypertension (PAHT), or the risk of developing PAHT, which includes determining the presence and/or amount of anti-tenascin C antibodies in a biological sample from a patient. | 2011-02-10 |
20110033877 | Method for Evaluation or Selection of Adiponectin Secretion Regulator - Provided is a method for conveniently and rapidly evaluating or selecting an adiponectin secretion regulator. | 2011-02-10 |
20110033878 | LUMINESCENT SUBSTRATE FOR LICIFERASE - The present invention relates to a compound having a structure analogous to firefly luciferin. In particular, the invention relates to a heterocycle compound which produces a luminescence at a light wavelength different from that of firefly luciferin in nature. The present invention provides a heterocycle compound of following general formula I. In the above general formula, R | 2011-02-10 |
20110033879 | DIRECT ASSAY OF CHOLESTEROL IN SKIN REMOVED BY TAPE STRIPPING - Skin cholesterol is measured by applying an adhesive tape onto a selected area of the skin to adhere the tape to the selected skin area and stripping the tape off the selected skin area to obtain a sample representative of the outer stratum corneum layer of the skin, the sample adhering to the tape so as to have exposed skin constituents. The sample is assayed using a detector reagent that specifically binds to cholesterol and in addition has an indicator component that allows quantitation of the amount of cholesterol present in the exposed skin constituents. | 2011-02-10 |
20110033880 | FAD-CONJUGATED GLUCOSE DEHYDROGENASE GENE - An object of the present invention is to provide: a novel gene (polynucleotide) encoding an FAD-conjugated glucose dehydrogenase having excellent properties that it has excellent reactivity to glucose, excellent thermal stability, and excellent substrate-recognition performance and also has a low activity for maltose; a process for the production of the enzyme using a transformant cell transfected with the gene; and a method for the determination of glucose, a reagent composition for use in the determination of glucose, a biosensor for use in the determination of glucose and others, each characterized by using the enzyme obtained. The invention relates to a polynucleotide encoding an FAD-conjugated glucose dehydrogenase, comprising a polypeptide containing an amino acid sequence: X1-X2-X3-X4-X5-X6 (wherein X1 and X2 independently represent an aliphatic amino acid residue; X3 and X6 independently represent a branched amino acid residue; and X4 and X5 independently represent a heterocyclic amino acid residue or an aromatic amino acid residue); and others. | 2011-02-10 |
20110033881 | SYSTEM FOR DETECTING MICROBIAL CONTAMINATION - The present invention relates to a system for detecting microbial contamination of a liquid specimen comprising a device for concentrating micro-organisms from a liquid specimen, having (i) a hyperbaric chamber, (ii) a filter housing comprising a liquid-permeable bed of an adsorbent material and adapted for being fluidly connected to said hyperbaric chamber, and (iii) a means for pressurizing said hyperbaric chamber, said system further comprising a kit for detection of micro-organisms adsorbed to said adsorbent material, wherein said kit is based on enzymatic detection using chromogenic and/or fluorescent substrate analogues. | 2011-02-10 |
20110033882 | VARIANTS OF THE BACILLUS LICHENIFORMIS ALPHA-AMYLASE - Variants of | 2011-02-10 |
20110033883 | IMAGING DYES AND USE THEREOF - Use of a metal complex having the formula: [M(L | 2011-02-10 |
20110033884 | PD-1, A Receptor for B7-4, and Uses Therefor - Disclosed is a method for modulating an immune response by modulating signaling via PD-1. The immune response may be downregulated by increasing signaling via PD-1, or may be upregulated by decreasing signaling via PD-1. Agents which are useful for stimulating signaling via PD-1 to downregulate an immune response include an activating antibody that recognizes PD-1, a form of B7-4 that binds to an inhibitory receptor, and a small molecule that binds to PD-1. Agents which are useful for inhibiting signaling via PD-1 to upregulate an immune response include a blocking antibody that recognizes PD-1, a non-activating form of B7-4, an antibody that recognizes B7-4, and a soluble form of PD-1. Also disclosed is a method for modulating the interaction of B7-4 with an inhibitory receptor on an immune cell. The method comprises contacting an antigen presenting cell which expresses B7-4 with an agent such as a form of B7-4, a form of PD-1, or an agent that modulates the interaction of B7-4 and PD-1. Also disclosed is a method for inhibiting activation of an immune cell via a non-apoptotic mechanism by increasing the activity or expression of PD-1 in the immune cell. The disclosed methods for modulating an immune response are useful, for instance as therapeutic treatment of a subject with conditions that would benefit from immune response modulation. For instance, a condition such as a tumor, a neurological disease, or an immunosuppressive disease, would be treated by upregulating an immune response, and conditions such as a transplant, an allergy, or an autoimmune disorder would benefit from downregulation of an immune response. Assays for identifying compounds which modulate the activity of, or signaling via, B7-4, or PD-1, especially which modulate the binding of B7-4 or PD-1 to a target molecule are also disclosed. Further disclosed are a vaccine and also other compositions which contain agents that modulate signaling via PD-1. | 2011-02-10 |
20110033885 | METHOD FOR MANUFACTURING A TISSUE-ENGINEERED CONSTRUCT - Method for manufacturing a tissue-engineered construct, such as a heart valve, comprising the steps of providing a-cell-seeded scaffold in a bioreactor chamber which bioreactor chamber is divided by the cell-seeded scaffold into a first compartment and a second compartment, subjecting the cell-seeded scaffold to a flow of nutrient medium within the bioreactor chamber for developing the cell-seeded scaffold to a tissue structure and next to the tissue construct, applying a dynamic pressure difference to the developing tissue structure by the flow of nutrient medium to induce dynamic strain on the tissue structure. | 2011-02-10 |
20110033886 | GDF-15 AS BIOMARKER IN TYPE 1 DIABETES - The present invention relates to a method of predicting if a diabetes type 1 patient will suffer from one or more complications selected from cardiovascular complications, terminal renal failure, and death, the method including (a) determining the amount of GDF-15 in a sample of a diabetes type 1 patient; and (b) comparing the amount of GDF-15 determined in step (a) to a reference amount and establishing a prediction. Also encompassed by the present invention are devices and kits for carrying out the aforementioned methods. | 2011-02-10 |
20110033887 | Three-Dimensional Microfabricated Bioreactors with Embedded Capillary Network - In an aspect, the present invention uses projection micro stereolithography to generate three-dimensional microvessel networks that are capable of supporting and fostering growth of a cell population. For example, provided is a method of making a microvascularized bioreactor via layer-by-layer polymerization of a photocurable liquid composition with repeated patterns of illumination, wherein each layer corresponds to a layer of the desired microvessel network. The plurality of layers are assembled to make a microvascular network. Support structures having different etch rates than the structures that make up the network provides access to manufacturing arbitrary geometries that cannot be made by conventional methods. A cell population is introduced to the external wall of the network to obtain a microvascularized bioreactor. Provided are various methods and related bioreactors, wherein the network wall has a permeability to a biological material that varies within and along the network. | 2011-02-10 |
20110033888 | METHOD FOR PRODUCING SWEET JUICE FROM LIGNOCELLULOSIC BIOMASS WITH IMPROVED ENZYME RECYCLE - The present invention relates to a method of producing sweet juice from lignocellulosic substrate, wherein enzymatic hydrolysis is carried out by performing cellulase supplementation with supported β-glucosidases used in a reactor separate from the lignocellulose enzymatic hydrolysis reactor. | 2011-02-10 |
20110033889 | APPARATUS AND METHOD FOR HYDROLYSIS OF A PROTEIN CONTAINING RAW MATERIAL AND APPLICATION OF THE RESULTING HYDROLYSIS PRODUCTS - Apparatus and methods for hydrolyzing protein-containing raw material into water soluble protein and other products. The apparatuses and methods comprise an optional collection or processing stage in which protein-containing raw material, such as fish or animal carcasses from food production plants, are collected and optionally processed. The raw material is then reacted with one or more enzymes to hydrolyze the protein present, after which the one or more enzymes are inactivated and the components separated. The processes and apparatuses, which can be run as a batch processes or, advantageously as a continuous processes, can yield water soluble protein, oils, bone meal and other products that have utility as food or food additives. | 2011-02-10 |
20110033890 | METHOD FOR THE SECRETORY PRODUCTION OF HETEROLOGOUS PROTEIN IN ESCHERICHIA COLI - The present invention relates to a signal sequence peptide for the improvement of extracellular secretion efficiency of a heterologous protein in | 2011-02-10 |
20110033891 | MUSSEL BIOADHESIVE - The present invention relates to a bioadhesive derived from mussel. In particular, it relates to a novel | 2011-02-10 |
20110033892 | NOVEL MEMBERS OF THE CAPSAICIN/VANILLOID RECEPTOR FAMILY OF PROTEINS AND USES THEREOF - The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing hVR-1, hVR-2, and rVR-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an hVR-1, hVR-2, and rVR-2 gene has been introduced or disrupted. The invention still further provides isolated hVR-1, hVR-2, and rVR-2 proteins, fusion proteins, antigenic peptides and anti-hVR-1, anti-hVR-2, and anti-rVR-2 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. | 2011-02-10 |
20110033893 | IMPROVED METHODS FOR PROTEIN PRODUCTION - Methods for low cell-density bacterial protein expression that can achieve levels of up to 180 mg/l using a simple and low cost strategy. Full codon optimization is unnecessary to improve expression of viral genes rich in | 2011-02-10 |
20110033894 | ENGINEERING SURFACE EPITOPES TO IMPROVE PROTEIN CRYSTALLIZATION - Methods and systems for engineering surface epitopes, based on protein sequence characteristics with statistically significant influence on the likelihood of x-ray structure solution, to improve protein crystallization, as well as related material, are disclosed. | 2011-02-10 |
20110033895 | Method For Producing Human Antibodies With Properties Of Agonist, Antagonist, or Inverse Agonist - A method for obtaining agonist, antagonist and inverse agonist, to a given physiological receptor is disclosed. For the method, use is made of in silico design synthetic immunogens, which are caused to act in vitro on human lymphocyte-containing cell populations. A preferred receptor is human CD152, particularly the regions of CDR1, CDR2 and CDR3 that elicit antibodies serving as antagonist, inverse agonist and agonist, respectively. Also provided is a method in the treatment of human peripheral lymphocytes for use in the screening of CD152 ligands that yield pharmacological effects. | 2011-02-10 |
20110033896 | METHOD FOR MANUFACTURING AN AQUEOUS GLUCOSE SOLUTION FROM PLANTS OF THE TRITICEAE SPECIES - The present invention relates to a method for manufacturing an aqueous glucose solution from the starch components of Triticeae grains, for example from rye, triticale or in particular wheat grains. The invention also relates to a glucose-based fermentation method for manufacturing organic compounds in which the glucose manufactured for fermentation is produced from the starch components of Triticeae grains by way of a method according to the invention. | 2011-02-10 |
20110033897 | Method for the Obtainment of Hydrolytic Enzymes, Hydrolytic Method for Producing Fermentable Sugars, Additives comprising Fermentable Sugars, and Process for Producing Ethanol from Sugar Cane Bagasse - The present invention provides industrial methods involving the hydrolysis of sugar cane bagasse, including methods for producing hydrolytic enzymes, for hydrolysis of sugar cane bagasse, for the production of additives comprising fermentable sugars and the respective additives, and methods of producing ethanol. The invention methods comprised the submerged culture of | 2011-02-10 |
20110033898 | METHOD FOR PRODUCING 5'-GUANYLIC ACID - 5′-guanylic acid (GMP) is produced efficiently by allowing a microorganism to react with xanthylic acid (XMP), wherein said microorganism is able to convert xanthylic acid into 5′-guanylic acid and has been modified so that the nagD gene does not function normally and 5′-guanylic acid synthetase activity is enhanced. | 2011-02-10 |
20110033899 | CONVECTION POLYMERASE CHAIN REACTION METHOD - The invention relates to a method for rapid detection of specific nucleic acid fragments with the aid of a PCR, consisting in amplifying target products in a special DNA thermocycler, provided with a special reaction thermal unit, which makes it possible to obtain, in reaction vessels in the form of standard polypropylene test tubes, a sloping temperature gradient directed at an angle to the direction of gravity. The amplification time is of 1-5 minutes. The inventive method can be recommended for DNA diagnostics, also field conditions, in medicine, veterinary sciences, in sanitary and epidemiological studies for detecting agents of dangerous infections, including potential bio-terrorist attacks, in criminalistics for identifying criminals in the food industry for detecting food products from genetically modified organisms, for testing raw material quality etc. | 2011-02-10 |
20110033900 | Trichoderma Reesei Glucoamylase and Homologs Thereof - The present invention is related to glucoamylases having at least 80% sequence identity to a | 2011-02-10 |
20110033901 | COMPOSITIONS OF AND METHODS OF USING SULFATASES FROM FLAVOBACTERIUM HEPARINUM - This invention is related, in part, to sulfatase enzymes and methods of their use. | 2011-02-10 |
20110033902 | L-CYSTEINE-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING L-CYSTEINE - L-Cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has L-cysteine-producing ability and has been modified so that the activity of a protein encoded by a tolC gene, for example, a protein defined in the following (a) or (b), is increased in a medium, and by collecting L-cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof from the medium:
| 2011-02-10 |
20110033903 | Isolated population of plant single cells and method of preparing same - This invention is a method of minimizing the variation of cell growth and production through homogeneous cell line development. To be more specific, it is the method of isolating and proliferating single cell clone from cambium to promote the stability of the plant-derived biologically active substances production by solving the problems of decrease in cell growth and the productivity during the long term culture. | 2011-02-10 |
20110033904 | METHOD FOR PREPARING ORTHODIHYDROXYISOFLAVONES USING A BIOTRANSFORMATION SYSTEM - Disclosed herein is a method for preparing ortho-dihydroxyisoflavones using a biotransformation system. More specifically, disclosed is a method for preparing ortho-dihydroxyisoflavones, which comprises biotransforming daidzein or genistein by actinomycete microorganisms, particularly | 2011-02-10 |
20110033905 | PROCESS FOR PRODUCING OPTICALLY-ACTIVE ORTHO-SUBSTITUTED MANDELIC ACID COMPOUND - The present invention provides a process of asymmetrically reducing an ortho-substituted phenylglyoxalic acid compound to produce a corresponding optically-active ortho-substituted mandelic acid compound by using a microorganism having an ability of reducing the ortho-substituted phenylglyoxalic acid compound into the optically-active ortho-substituted mandelic acid compound, or a treated product thereof. | 2011-02-10 |
20110033906 | METHOD FOR PRODUCING USEFUL SUBSTANCE FROM CELLULOSE-CONTAINING MATERIAL - The present invention provides a method for producing a useful substance efficiently from cellulose without using any cellulase preparation. According to the disclosures of the present specification, in the production of a useful substance from a cellulose-containing material, the cellulose-containing material is brought into contact with an ionic liquid to cause the ionic liquid to permeate the cellulose-containing material, and a carbon source comprising the cellulose in the cellulose-containing material is simultaneously saccharified and fermented by a cellulase-producing microorganism in the presence of the ionic liquid. | 2011-02-10 |
20110033907 | YEAST STRAINS FOR IMPROVED ETHANOL PRODUCTION - Novel strains of yeast and methods for improved ethanol production utilizing the yeast strains are disclosed. In particular, the novel yeast strains | 2011-02-10 |
20110033908 | METHODS FOR SELECTIVELY PRODUCING HYDROGEN AND METHANE FROM BIOMASS FEEDSTOCKS USING AN ANAEROBIC BIOLOGICAL SYSTEM - The present invention provides a method for selective production of hydrogen and methane from a biomass feedstock in a reactor vessel maintained under anaerobic conditions by controlling moisture concentration in the reactor vessel. The method comprises the steps of introducing a biomass feedstock into the reactor vessel maintained under anaerobic conditions; introducing a bacterial inoculum into the reactor vessel to facilitate digestion of the biomass feedstock; setting a moisture concentration of the contents of the reactor vessel at a first moisture level; and collecting hydrogen gas from the reactor vessel. The method may further comprise maintaining the moisture concentration at a first moisture level or within a first moisture range. The method may additionally comprise increasing the moisture concentration of the contents of the reactor vessel to a second moisture concentration; and collecting methane gas from the reactor vessel. Switching between hydrogen and methane production is controlled by adjusting the moisture concentration of the contents of the reactor vessel. | 2011-02-10 |
20110033909 | MEANS AND METHODS FOR CLONING NUCLEIC ACID SEQUENCES - The invention provides means and methods for efficiently cloning nucleic acid sequences of interest in micro-organisms that are less amenable to conventional nucleic acid manipulations, as compared to, for instance, | 2011-02-10 |
20110033910 | CELL SELECTION APPARATUS, AND CELL SELECTION METHOD USING THE SAME - The cell selection apparatus includes: a cell selection vessel which has a pair of electrodes and a sheet-like insulating material having a plurality of micropores, with a recognition molecule bindable to the specific substance being disposed on a bottom face of the micropore; and a power supply, wherein the power supply includes a cell-immobilization power supply and a cell-taking power supply. The cell selection method uses the cell selection apparatus, including; introducing cells into a cell selection area; immobilizing these cells in the micropores; effecting a binding reaction between the specific substance and the recognition molecule; thereafter, taking out a cell of which the specific substance is not or is weakly bound to the recognition molecule, from the micropore; otherwise alternatively, leaving a cell of which the specific substance on the surface of the cell is strongly bound to the recognition molecule, behind in the micropore. | 2011-02-10 |
20110033911 | Episomal fusion gene - The present invention relates to an episomal structure expressing a functional oncogene, whereby said oncogene is a fusion gene of two chromosomal gene fragments. More specifically, the invention relates to a NUP214-ABL1 fusion product, important in the development of T-cell acute lymphoblastic leukemia, to methods to detect the fusion and to methods to prevent the oncogenic activity of said fusion product. | 2011-02-10 |
20110033912 | Photobioreactor and a process for enhancing growth of photosynthetic organisms - A photobioreactor apparatus in which a reaction chamber contains a slurry of water, nutrients and photosynthetic organisms. The sidewall of the reaction chamber is constructed of translucent material, thereby permitting light to be conveyed into the slurry to promote photosynthesis. The interior of the reaction chamber is in fluid communication with a gas dispenser. A lift member is disposed in the reaction chamber and gas is introduced in the slurry beneath the lift member, thereby providing buoyancy to lift the lift member, thereby providing agitation and movement of the slurry within the photobioreactor and enhancing growth of photosynthetic organisms. | 2011-02-10 |
20110033913 | METHOD AND APPARATUS FOR THEMICROBIOLOGICAL REMOVAL OF MERCURY FROM CONTAMINATED MATERIALS, - The present invention relates to microorganisms able to reduce mercury ion to metallic mercury; in particular, it refers to systems, apparatuses such as a stirred bioreactor and methods for microbiological mercury removal from contaminated materials, such as, e.g., contaminated environmental matrices, like soil and sediments. The contaminated material is mixed with selected microrganisms capable to enable enzymatic reduction of mercury in ionic form to elemental mercury. | 2011-02-10 |
20110033914 | In Vitro Model of Latent Mycobacterial Infection - A method of inducing latency in | 2011-02-10 |
20110033915 | In Vitro Model of Latent Mycobacterial Infection - A method of inducing latency in | 2011-02-10 |
20110033916 | ORGAN TRANSPORT CONTAINER SYSTEM - An organ transport container system for storing and transporting therein an organ coupled to a perfusion system for preserving the viability of the organ for implantation by perfusing the organ with a perfusion liquid. The container system includes a cartridge for carrying the organ and a receptacle for holding a volume of the perfusion liquid and for removably holding therein the cartridge in a transport position. The cartridge has a holder for supporting the organ and relay conduit extending between an artery connector for sealingly connecting the relay conduit to an artery of the organ in the holder and an inlet. An outlet of a passage through the receptacle wall or bottom and the inlet are positioned and arranged such that the outlet and the inlet are sealingly coupled to each other when the cartridge is brought in the transport position, for allowing preservation liquid supplied via the supply conduit to be relayed to the artery via the relay conduit when the cartridge is in the transport position. | 2011-02-10 |
20110033917 | SENSOR WITH LONG-TERM STABILITY FOR BIOPROCESSES - A sensor for registering a measured variable of a medium, especially in a bioprocess. The sensor includes a sensor body, wherein at least one surface section of the sensor body can be supplied with the medium, and wherein a condition of this surface section affects the measured value. The sensor is characterized by the fact that the surface section contains a substance with biocidal properties. | 2011-02-10 |
20110033918 | ROTATING BIOREACTOR - Articles and methods for growing tissues and organs using bioreactors, including rotating bioreactors, are provided. In some embodiments, a bioreactor is configured to provide a first and second chamber, such as an inner and an outer chamber, respectively. The chambers may be co-axially arranged with respect to each other. A wall of the bioreactor defining the two chambers may be formed at least in part from a scaffold derived from a length of a hollow or tubular tissue or organ. Such a bioreactor can be used to form biocompatible structures for tissue engineering and organ replacement, such as cellular tissues, organ-like structures, and/or complete organs, within the bioreactor. | 2011-02-10 |
20110033919 | METHOD OF REDUCING TEMPERATURE DIFFERENCE BETWEEN A PAIR OF SUBSTRATES AND FLUID REACTION DEVICE USING THE SAME - A method of reducing a temperature difference between a high-temperature and a low-temperature substrate includes interposing a heat transfer facilitating layer which has a higher thermal conductivity than air and can hold particles between the substrates, and maintaining close contact between the high-temperature substrate, the heat transfer facilitating layer, and the low-temperature substrate, wherein formation of an air layer can be at least substantially prevented between the high-temperature substrate and the heat transfer facilitating layer, and between the low-temperature substrate and the heat transfer facilitating layer. A fluid reaction device includes a microfluidic reaction chip which accommodates a fluid, a heater, and a heat transfer facilitating layer which is interposed between the microfluidic reaction chip and the heater, the heat transfer facilitating layer has a higher thermal conductivity than air and can hold particles, wherein formation of an air layer can be prevented. | 2011-02-10 |
20110033920 | COMPOSITIONS AND METHODS FOR USE IN RECOMBINATIONAL CLONING OF NUCELIC ACIDS - The present invention relates generally to compositions and methods for use in recombinational cloning of nucleic acid molecules. In particular, the invention relates to nucleic acid molecules encoding one or more recombination sites or portions thereof, to nucleic acid molecules comprising one or more of these recombination site nucleotide sequences and optionally comprising one or more additional physical or functional nucleotide sequences. The invention also relates to vectors comprising the nucleic acid molecules of the invention, to host cells comprising the vectors or nucleic acid molecules of the invention, to methods of producing polypeptides using the nucleic acid molecules of the invention, and to polypeptides encoded by these nucleic acid molecules or produced by the methods of the invention. The invention also relates to antibodies that bind to one or more polypeptides of the invention or epitopes thereof. The invention also relates to the use of these compositions in methods for recombinational cloning of nucleic acids, in vitro and in vivo, to provide chimeric DNA molecules that have particular characteristics and/or DNA segments. | 2011-02-10 |