06th week of 2022 patent applcation highlights part 12 |
Patent application number | Title | Published |
20220040414 | DIABETES THERAPY MANAGEMENT SYSTEMS, METHODS, AND DEVICES - Diabetes management systems include an insulin delivery device and a monitoring device for detecting at least one characteristic relating to the insulin delivery device. Monitoring devices may comprise pen caps. | 2022-02-10 |
20220040415 | MEDICATION DELIVERY DEVICE WITH GEAR SET DOSAGE SYSTEM - A medication delivery device is disclosed including a rack-and-pinion plunger drive system. The drive system includes an output drive having a pawled end movably coupled with the ratchet teeth of the plunger, and a pinion drive coupled between the housing, the output drive and an actuator. Actuator is longitudinally movable between dose set and delivery positions. Movement of the actuator causes rotation of the pinion drive along the rack to translate the output drive member with the pawled end that is engaged with the plunger ratchet teeth to distally advance the plunger. The device may include one or more of an end of dose mechanism to limit travel of the actuator, a load brake system to stop travel of the plunger under high input forces, a dose detection system, and a dose selector to vary the amount of dose set. | 2022-02-10 |
20220040416 | Displacement Device, Testing Device and Method for Leakage Testing of a Connection of a Tip Cap with a Syringe - The present invention relates to a displacement device, DD, for providing a displacement of a syringe closure system for a syringe relative to the syringe, a testing device, TD, and a method for leakage testing of a connection of a syringe closure system for a syringe with the syringe. | 2022-02-10 |
20220040417 | Nocireceptor Blockade - Systems, Methods and Devices to apply concomitant cold and vibratory stimulus immediately prior to injection to reduce pain, in a simple and mechanically advantaged device actuatable by a user's non-dominant hand or a third party. | 2022-02-10 |
20220040418 | A DOSING REGULATOR AND RECOMMENDATIONS ENGINE - A vibrating mesh nebuliser. The nebuliser ( | 2022-02-10 |
20220040419 | FILTER CARTRIDGE ASSEMBLIES - A filter cartridge for a surgical gas delivery system is disclosed which includes a housing having a front end and a rear end and defining a first interior flow path extending downstream from a first inlet at the rear end of the housing to a first outlet at the front end of the housing, and a second interior flow path extending upstream from a second inlet at the front end the housing to a second outlet at the rear end of the housing, a first pleated filter element operatively associated with the first interior flow path, a second pleated filter element operatively associated with the second interior flow path, and a carbon filter disc operatively associated with the second interior flow path and positioned adjacent a downstream side of the second pleated filter element. | 2022-02-10 |
20220040420 | DRY POWDER INHALER - The present invention provides an inhaler comprising a housing which contains a blister strip having a plurality of blisters which contain powdered medicament for inhalation; a mouthpiece through which the medicament is inhaled by a user; an indexing wheel for indexing the blister strip; an opening mechanism for opening the blisters; an actuator which is movable between a first position and a second position in order to operate the indexing wheel and the opening mechanism; and a coupling mechanism for coupling the actuator to the indexing wheel so that the indexing wheel rotates together with the actuator during part of the motion of the actuator; characterized in that the coupling mechanism comprises a shuttle that rotates on the same axis as, and translates axially relative to, the indexing wheel. | 2022-02-10 |
20220040421 | A MULTI-USERS MEDICAL CANNABIS DISPENSER - Provided is a multi-users cannabis dispenser comprising: a vessel comprising at least two compartments, each compartment configured to contain at least one cannabis composition comprising at least one active component; at least one dispensing unit associated with said at least one compartment, said dispensing unit configured to controllably release from said compartments a metered dose of said composition contained therein; a control unit comprising a data input unit configured to receive data relating to a specific user, data indicating a metered dose of one or more said cannabis compositions to be administered to said specific user and/or to receive data relating to a specific cannabis composition, data indicating a metered dose of said specific composition to be administered to said specific user and configured to control the dispensing unit to release at least one said metered dose. Further provided are methods of use of the multi-users cannabis dispenser. | 2022-02-10 |
20220040422 | AEROSOL DELIVERY DEVICE AND METHOD UTILIZING A FLAVORING RESERVOIR - Disclosed herein is a device configured to impart flavoring to an airstream admitted the device prior to the airstream reaching an aerosol generator of the device, the device thereby operable to deliver a flavored aerosol from an outlet. | 2022-02-10 |
20220040423 | MOBILE INHALER AND A CONTAINER FOR USING THEREWITH - A mobile inhaler is provided and a container for using therewith. The mobile inhaler comprises: a mouthpiece comprising at least one inhaling opening; a body element connected to the mouthpiece and comprising a housing for holding a DC power source; a power conversion unit comprising an inverter operative to convert a DC voltage provided by a DC power source, into a higher AC voltage; a nebulizer comprising an ultrasonic vibrator and a mesh, wherein the ultrasonic vibrator is activated by the AC voltage, and wherein the nebulizer is adapted to enable converting into aerosol droplets at least part of a liquid comprised in an enclosure, and the aerosol droplets to be directly inhaled from the mouthpiece; and an enclosure adapted to enable holding a liquid, and characterized in that it provides a connection to enable fluid transfer from the enclosure to the nebulizer. | 2022-02-10 |
20220040424 | NASAL CAVITY SAMPLING METHODS AND APPARATUS - Disclosed herein, are compositions, methods, systems, and apparatus for collecting biological material from the nasal cavity of a subject or the olfactory region of a subject's nasal cavity. In some embodiments, the biological material is collected from a targeted sub-region of the nasal cavity, such as a targeted sub-region of the olfactory region, wherein such biological material is specific to the targeted sub-region. In some embodiments, the biological material collected from a targeted sub-region is preserved according to its localization. In some embodiments, the biological material comprises cerebrospinal fluid, one or more microbes of the patient's microbiome, one or more components of the patient's metabolome, one or more pathogens, and/or one or more biomarkers of interest. In some embodiments, a specific formulation is delivered to the region in the nasal cavity for facilitating biological material collection located therein. | 2022-02-10 |
20220040425 | Flow Triggered Gas Delivery - A fluid delivery system provides fluid, such as supplement oxygen, to a patient in response to inhalation. The fluid delivery system includes a valve assembly that is triggered by sensing onset of inspiration by measuring a change in temperature of air flow in a nasal or oral cannula, mask or helmet. | 2022-02-10 |
20220040426 | Flow Triggered Gas Delivery - A fluid delivery system provides fluid, such as supplement oxygen, to a patient in response to inhalation. The fluid delivery system includes a valve assembly that is triggered by sensing onset of inspiration by measuring a change in temperature of air flow in a nasal or oral cannula, mask or helmet. | 2022-02-10 |
20220040427 | DEVICE AND PROCESS FOR MEASURING THE LUNG COMPLIANCE - A device and a process determine a value indicative of a respective regional compliance of lungs of a patient (P) in a plurality of different regions of the lungs. An airway pressure sensor ( | 2022-02-10 |
20220040428 | Ventilation Devices and Systems and Methods of Using Same - A ventilation system having a mask, a blowing assembly, and a processor. The mask has a mask body and a pressure sensor operatively associated with the mask body and configured to measure pressure within the mask. The mask body defines an inlet opening and a plurality of leak openings. The blowing assembly is positioned in fluid communication with the inlet opening of the mask body and configured to direct air to the inlet opening of the mask body. The processor is positioned in operative communication with the blowing assembly and the pressure sensor of the mask. The processor is configured to selectively control the blowing assembly based upon at least the measured pressure within the mask. | 2022-02-10 |
20220040429 | AIRWAY MANAGEMENT SYSTEM WITH SELECTIVELY PRESSURIZED VALVE - Devices, systems, and methods of facilitating airway management with reduced risk of release of droplets and aerosolized pathogens from the lungs of a patient are disclosed, including a bronchoscope adapter for an endotracheal tube, an endotracheal tube with integral bronchoscope adapter, an endotracheal intubation mask system, a laryngeal mask airway-specific mask system, and a quick-seal laryngeal mask airway-specific mask system. | 2022-02-10 |
20220040430 | RESPIRATORY MASK SEALING INTERFACE - A sealing interface includes an inner cushion and an outer sheath. The outer sheath substantially seals against the facial contours of the user. The inner cushion and the outer sheath each have a nasal bridge region, left and right cheek regions and either one of an upper lip region or a chin region. In use these regions are aligned with the corresponding nasal bridge region, left and right cheek regions and either the upper lip region or the chin region of a user. The inner cushion includes a hinged region. The hinged region is adapted to flex substantially independently of the inner cushion cheek regions. | 2022-02-10 |
20220040431 | GAS WASHOUT VENT FOR PATIENT INTERFACE - A gas-washout vent includes a housing with a first wall with one or more passages through the wall configured to provide fluid communication with a portion of the patient interface system exposed to a therapy pressure. The passages include respective first openings on a first surface of the first wall. The housing at least partially defines a second opening in communication with ambient atmosphere. A diffusing material is located at least partially within the housing to be adjacent the first surface. A surface of the diffusing material facing the first surface is spaced away from the first surface by a gap that extends to provide a fluid communication between all of the first openings and between all of the first openings and the second opening. The housing is configured so that air is prevented from flowing out of the housing at all areas directly opposite each of the first openings. | 2022-02-10 |
20220040432 | PATIENT INTERFACE - A patient interface includes a first body that rests on a first portion of a patient's face, a second body that rests on a second portion of the patient's face, and a bridge linking the first and second bodies. The patient interface includes an attachment structure that couples with a complementary fixation structure positioned on the patient's face to secure the patient interface to the patient's face. The complementary fixation structure can be configured to assist in retaining a feeding tube in position relative to the patient's face or to the patient interface. | 2022-02-10 |
20220040433 | PATIENT INTERFACE SYSTEMS - A patient interface structure for delivery of respiratory therapy to a patient include a cushion assembly that has an elastomeric piece with a mouth seal portion configured to seal around the patient's mouth and a nasal seal portion configured to seal against at least an underside of the patient's nose. The cushion assembly also has a cushion clip that is chemically or mechanically bonded to the elastomeric piece and forms at least part of a plenum chamber with the elastomeric piece. The cushion clip is more rigid than the elastomeric piece. A front plate that is more rigid than the elastomeric piece and has a plurality of headgear attachment points is attachable to the cushion clip by way of a snap fit connection. A gas passage extends along a posterior surface of the front plate and includes an inlet opening configured to connect to an air delivery tube or a connector for an air delivery tube. | 2022-02-10 |
20220040434 | Fresh Air/Oxygen Portable Breathing Device With or Without Aromas and Methods of Use - The present invention provides a portable, light-weight, breathing device and methods of use for delivering pristine, fresh air or varying high concentrations of oxygen with or without aroma, i.e., essential oils for stimulating appetite, boosting mood or decreasing stress and anxiety. The breathing device comprises an air container having a breathing air bag therein which contains the fresh air or the varying concentrations of oxygen optionally with the one or more essential oils, tubing for delivering the fresh air or oxygen to a breathing mask, and a plurality of movable valves included in the mask which directs air or oxygen into or out of the mask depending on whether the user is inhaling or exhaling. The breathing device also comprises the use of a can of compressed fresh air or oxygen with or without aroma to be used with an air reservoir or with an expandable air bag. | 2022-02-10 |
20220040435 | APPARATUS FOR MEASURING PROPERTIES OF GASES SUPPLIED TO A PATIENT - The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermistor), of gases flowing through a heated tube, supplying gases to a patient, which utilises the heating wire within the tube. | 2022-02-10 |
20220040436 | VALVE MODULE AND FILTER - A filter for an apparatus for delivering a flow of gas, the filter comprising: a filter body, wherein the filter body has a main compartment and a sub-compartment at least partly within the main compartment, wherein the main compartment is in fluid communication with a main compartment gases inlet and the sub-compartment is in fluid communication with a sub-compartment gases inlet; and a filter medium associated with both the main compartment and the sub-compartment, and that is arranged to filter gases in, or exiting, the main compartment and the sub-compartment. | 2022-02-10 |
20220040437 | ZONE HEATING FOR RESPIRATORY CIRCUITS - Some embodiments provide for an inspiratory limb for a breathing circuit that includes a first segment that comprises a first heater wire circuit and a second segment that comprises a second heater wire circuit. The inspiratory limb can include an intermediate connector that includes a connection circuit that electrically couples the first heater wire circuit to the second heater wire circuit. The inspiratory limb can be configured to operate in two modes wherein, in a first mode, electrical power passes through the first electrical connection to provide power to the first heater wire circuit without providing power to the second heater wire circuit, and in a second mode, electrical power pass through the first electrical connection to provide power to both the first heater wire circuit and the second heater wire circuit. | 2022-02-10 |
20220040438 | Devices And Methods For Engaging Indexed Valve And Pressurized Canister Assembly With Collar And For Linear Actuation By Plunger Assembly Into Fluid Communication With Device For Regulating Drug Delivery - A valve assembly comprising a housing and a valve, the valve being disposed within the housing, a first indexed member integral to the housing, the first indexed member adapted to be complementary to a second indexed member, and a radio frequency identification device adapted to communicate with a radio frequency receiver, the valve being configured to align with a canister, seal the canister and open in a single movement. A drug containment device having said valve assembly is also disclosed. | 2022-02-10 |
20220040439 | HUMIDIFIED GASES DELIVERY APPARATUS AND METHODS FOR CONTROLLING SAME - The invention relates to a method of determining water level in a humidifier chamber that is part of a humidified gases delivery apparatus and system. The method comprising the steps of delivering power to a heater plate, varying the power delivered to the heater plate, measuring the rate of change of temperature and determining the level of water based on the heating characteristics of the volume of water within the chamber, in particular determining the level of water within the chamber based on the rate of change of temperature and the supplied power. | 2022-02-10 |
20220040440 | HUMIDIFIER RESERVOIR - An apparatus for humidifying a flow of pressurised, breathable air includes varying a first pressure of the flow of breathable gas to vary a level of thermal engagement between the conductive portion of the reservoir and the heater plate, varying a height of the variable portion varies a level of thermal engagement between the conductive portion of the reservoir and the heater plate, use of a humidifier reservoir base component with a maximum water capacity substantially equal to the predetermined maximum volume of water of the humidifier reservoir or the use of intersecting inlet and outlet axes. | 2022-02-10 |
20220040441 | HUMIDIFIER RESERVOIR - An integrated respiratory pressure therapy device and humidifier for pressurising and humidifying breathable air to treat a respiratory disorder in a patient, includes a blower configured to pressurise the breathable air; a water reservoir configured to hold a volume of water to be used for humidification of the breathable air, the water reservoir comprising a water reservoir base, a water reservoir lid connected to the water reservoir base, and a compliant portion. The compliant portion is constructed from an elastomeric material and configured to seal between the water reservoir base and the water reservoir lid. A water reservoir dock forms a cavity configured to partially receive the water reservoir. The water reservoir lid includes a protrusion and the water reservoir dock includes a recess configured to releasably engage one another to secure the water reservoir to the water reservoir dock. | 2022-02-10 |
20220040442 | HUMIDIFIER RESERVOIR - An integrated respiratory pressure therapy device and humidifier for pressurising and humidifying breathable air to treat a respiratory disorder in a patient, includes a blower configured to pressurise the breathable air; a water reservoir configured to hold a volume of water to be used for humidification of the breathable air, the water reservoir comprising a water reservoir base, a water reservoir lid connected to the water reservoir base, and a compliant portion. The compliant portion is constructed from an elastomeric material and configured to seal between the water reservoir base and the water reservoir lid. A water reservoir dock forms a cavity configured to partially receive the water reservoir. The water reservoir lid includes a protrusion and the water reservoir dock includes a recess configured to releasably engage one another to secure the water reservoir to the water reservoir dock. | 2022-02-10 |
20220040443 | HUMIDIFIER RESERVOIR - An apparatus for humidifying a flow of pressurised, breathable air includes varying a first pressure of the flow of breathable gas to vary a level of thermal engagement between the conductive portion of the reservoir and the heater plate, varying a height of the variable portion varies a level of thermal engagement between the conductive portion of the reservoir and the heater plate, use of a humidifier reservoir base component with a maximum water capacity substantially equal to the predetermined maximum volume of water of the humidifier reservoir or the use of intersecting inlet and outlet axes. | 2022-02-10 |
20220040444 | Flow Triggered Gas Delivery - A fluid delivery system provides fluid, such as supplement oxygen, to a patient in response to inhalation. The fluid delivery system includes a valve assembly that is triggered by sensing onset of inspiration by measuring a change in temperature of air flow in a nasal or oral cannula, mask or helmet. | 2022-02-10 |
20220040445 | Flow Triggered Gas Delivery - A fluid delivery system provides fluid, such as supplement oxygen, to a patient in response to inhalation. The fluid delivery system includes a valve assembly that is triggered by sensing onset of inspiration by measuring a change in temperature or fluid flow of air flow in a nasal or oral cannula, mask or helmet. | 2022-02-10 |
20220040446 | INJECTION MOLDED CANNULA AND METHOD FOR MAKING SAME - A method, including the operations of molding a hollow cannula to create flash on the cannula at parting lines of a mold, retaining the flash on the cannula, and installing the cannula with the flash in a medical device. | 2022-02-10 |
20220040447 | Multi-Lumen Intravascular Catheters with inner Converging Lumens for Multiple Guidewire Control - Catheter systems with multiple inner lumens that converge at the catheter distal tip are preloaded with at least two guidewires. The catheters offers sequential probing with two or more guidewires, therefore improving on procedural speed and accuracy. The catheters comprise proximal and distal regions enabling angled lumens to merge into a common lumen with a diameter slightly larger to the largest of the two proximal lumens. The confluence of the two proximal lumens comprises a single lumen with a reduced profile and cross sectional area. The lumens merge with the larger lumen at an angle greater than zero degrees, and the distal tip has a diameter equal to the diameter of the smaller proximal lumen. The proximal region serves as a directed passageway for different guidewires that enter the catheter through two proximal lumens and which may be reoriented through a convergence region for sequential exiting of the catheter tip. | 2022-02-10 |
20220040448 | VENOUS ACCESS CATHETERS AND METHODS FOR PORTAL VENOUS SYSTEM CATHETERIZATION - The present invention contemplates devices and methods to administer nutritional compositions and/or therapeutic drugs directly into a portal venous system. For example, total parenteral nutrition therapy may be administered directly into the hepatic portal venous system thus circumventing known side effects of conventional parenteral administration. Alternatively, hepatic diseases and disorders may be treated using locally administered therapeutic drugs. Devices capable of direct portal venous system administration include, but are not limited to, a direct portal access catheter or a transjugular access catheter. | 2022-02-10 |
20220040449 | MINIMALLY INVASIVE CATHETER - Minimally invasive catheter relates to the field of eversible catheters. It is primarily intended for use as a urinary catheter, but is also usable in other fields. As a urinary catheter this minimally invasive catheter | 2022-02-10 |
20220040450 | MAGNETIC CONNECTOR FOR STEERABLE MEDICAL DEVICE - In a robot-assisted steerable medical device, such as a catheter, a magnetic connector hub is configured to establish mechanical and magnetic connection between a drive cable and an actuator, or between multiple modules in a single insert-and-twist motion. The connector hub creates a magnetic breakaway feature for automatically decoupling the actuator from the drive cable, while the catheter remains attached. This prevents damage to the catheter/tool and/or patient when an excessive force is applied, and adds a safety element and helps protect the patient. And when the breakaway occurs the system can be automatically reengaged catheter without damage, so that normal operation can resume. Connection can also be broken at any point in the operation based on threshold forces or emergency situations. | 2022-02-10 |
20220040451 | CATHETER HAVING TISSUE-ENGAGING DEVICE - An elongated catheter includes a tissue-engaging device configured to be urged to move and contact a first surface of the first biological wall. The tissue-engaging device extends from the distal catheter section. The tissue-engaging device is configured to be urged to puncture through the first biological wall. The tissue-engaging device is also configured to be urged to contact the first biological wall without impinging the second biological wall, after the tissue-engaging device has punctured through the first biological wall. | 2022-02-10 |
20220040452 | MEDICAL DEVICES WITH MULTI-PLANE ARTICULATION - Medical devices that provide for selected curve deflection in multiple planes such that three-dimensional shapes can be formed in the medical devices by placing a pull wire extending through the catheter in tension, as well as methods of manufacturing and using the medical devices. The medical devices may include selected portions in which the location of the pull wire changes circumferentially and/or radially to provide for the selected curve deflection. The medical devices may include, in addition to, or in place of changes in pull wire location, selected portions having exhibiting changes in rigidity to provide for the selected curve deflection. | 2022-02-10 |
20220040453 | MEDICAL DEVICES WITH MULTI-PLANE ARTICULATION - Medical devices that provide for selected curve deflection in multiple planes such that three-dimensional shapes can be formed in the medical devices by placing a pull wire extending through the catheter in tension, as well as methods of manufacturing and using the medical devices. The medical devices may include selected portions in which the location of the pull wire changes circumferentially and/or radially to provide for the selected curve deflection. The medical devices may include, in addition to, or in place of changes in pull wire location, selected portions having exhibiting changes in rigidity to provide for the selected curve deflection. | 2022-02-10 |
20220040454 | Optimized Catheter Sheath for Rx Catheter - A catheter configured for placement within a bodily lumen, comprises: a catheter sheath defining a first lumen for medical tools; and an exchange segment defining a second lumen for a guidewire. A proximal end of the exchange segment is joined with a distal end of the catheter sheath in a lengthwise direction forming an angle therebetween, such that the second lumen is laterally offset by a distance and angled with respect to the first lumen. When the catheter is placed within a patient's anatomy, the catheter sheath and/or the exchange segment straightens out so that the axis of the second lumen and the axis of the first lumen become substantially parallel to each other. The offset distance between the axes of sheath and exchange segment depends mainly on the diameter of the guidewire to be used, on the diameter of the sheath, and the angle of the junction. | 2022-02-10 |
20220040455 | FIXING DEVICE FOR FIXING A CATHETER ASSEMBLY TO A PATIENT - A device for fixing a catheter assembly to a patient has a receiving unit for connection to a skin surface of the patient. A receiving recess is arranged on the receiving unit to receive a portion of the catheter assembly. A closure unit is movable relative to the receiving recess between an opened state, in which the receiving recess is open for receipt and/or removal of the portion of the catheter assembly, and a closed state, in which the receiving recess is at least partially closed by the closure unit. The closure unit is joined non-releasably to the receiving unit. The receiving unit, at least in part, has shape elasticity such that the closure unit is movable between the opened state and the closed state by elastic deformation of the receiving unit. The device can be used in infusion therapy. | 2022-02-10 |
20220040456 | CATHETER ASSEMBLY - A catheter assembly is disclosed, which includes a catheter; a catheter hub fixed to a base end portion of the catheter; an inner needle having a needlepoint, inserted into the catheter; a needle hub coupled to the inner needle; a needle support portion configured to support the inner needle through the catheter on a leading end side beyond the catheter hub, the needle support portion having a pair of support arms openable and closeable in a different direction to an axis of the inner needle; a restraining portion capable of restraining the pair of support arms in a closed state and releasing a restraint of the pair of support arms; and wherein the restraining portion is movable with respect to the pair of support arms by a distal movement of the catheter hub relative to the inner needle, which releases the restraint with respect to the pair of support arms. | 2022-02-10 |
20220040457 | DEVICES AND METHODS FOR TREATING A STRICTURE ALONG THE BILIARY AND/OR PANCREATIC TRACT - Medical devices and systems for treating a stricture along the biliary and/or pancreatic tract are disclosed. An example medical device may include a guidewire for use along the biliary and/or pancreatic tract. The guidewire may include an elongate core member having a proximal end region and a distal end region. A coil member may be disposed along the distal end region. An actuation member may be coupled to the coil member. The actuation member may be configured to shift the coil member between a first configuration and a compressed configuration. The coil member may be configured to be advanced across a biliary and/or pancreatic stricture when in the compressed configuration. A sleeve may be disposed over the coil member. | 2022-02-10 |
20220040458 | MECHANIZED SURGICAL DRAIN AND METHOD OF USE - A drainage system that includes a mechanized surgical drain and drive mechanism for draining body matter from a body cavity. The mechanized surgical drain comprises a carrier mechanism within a surgical drain tube. The drive mechanism provides motion capabilities to a carrier mechanism within the lumen of the surgical drain tube. The motion capabilities of the carrier mechanism inhibits occlusion of the surgical drain tube by dislodging body matter and moving the body matter through the surgical drain to a suction port for removal to a collection container. | 2022-02-10 |
20220040459 | Apparatus for Minimally-Invasive Prevention and Treatment of Hydrocephalus and Method for Use of Same - An apparatus for minimally-invasive, including non-invasive, prevention and/or treatment of hydrocephalus and method for use of the same are disclosed. In one embodiment of the apparatus, a housing is sized for superjacent contact with a skull having a fontanel. Within the housing, a compartment includes a pressure applicator, such as a fluid-filled bladder, under the control of a pressure regulator. The pressure applicator is configured to selectively apply an external pressure to the fontanel. The compartment includes a pressure sensor configured to measure intracranial pulse pressure of the fontanel. Further, in one embodiment, the apparatus can cause pulse pressure modulation by adjusting the intracranial pulse pressure via the pressure applicator. This enables a non-invasive measurement of the pulse pressure and modulation thereof in infants, for example. | 2022-02-10 |
20220040460 | SYSTEMS AND METHODS FOR TREATING A STRICTURE ALONG THE BILIARY AND/OR PANCREATIC TRACT - Systems and methods for treating a stricture, for example along the biliary and/or pancreatic tract, are disclosed. An example system may include a handle having a base, a first carriage translatable relative to the base, and a second carriage translatable relative to the base. A sheath may be coupled to the first carriage. The system may also include a catheter shaft having a proximal end region and a steerable distal end region. The proximal end region may be coupled to the second carriage. A needle may be releasably coupled to the handle. The needle may be configured to pass through tissue into a position along the biliary and/or pancreatic tract. The system may also include a steering member having a first end coupled to the steerable distal end region of the catheter shaft and a second end disposed adjacent to the handle. | 2022-02-10 |
20220040461 | MULTI-LUMEN DRUG DELIVERY DEVICES AND METHODS - Drug delivery devices are provided herein and include an elongated, elastic body extending between a first end and a second end, wherein the elastic body comprises a water permeable wall structure having defining an elongated drug reservoir lumen extending between the first and second ends. One or more secondary lumens are structured (e.g., positioned, sized, shaped, and optionally filled) to be effective to retard or prevent in vivo diffusion of (i) water into the drug reservoir lumen and/or (ii) solubilized drug out of the drug reservoir lumen. | 2022-02-10 |
20220040462 | A SYSTEM AND METHOD FOR PREPPING LIQUID - The system comprises of a fluid container, a replaceable applicator head and a compatible, viscous antiseptic solution. The primary advantage is substantially drip free application. The system is non-vented and non-collapsible. The fluid container is non-compressible and comprises a prepping solution, a threaded spout and a container seal. The applicator head consists of a body to which a foam pad is attached and a channel through which the solution flows into the foam when the applicator head is connected to the fluid container. The applicator head when fixed onto the fluid container breaks the seal and creates a continuous channel that is non-vented for the solution to flow into the foam pad. | 2022-02-10 |
20220040463 | SILICON CARBIDE NANONEEDLES AND FABRICATION THEREOF - A product includes an elongated carbon-containing pillar having a bottom and a tip opposite the bottom. The width of the pillar measured 1 nm below the tip is less than 700 nm. A method includes masking a carbon-containing single crystal for defining masked regions and unmasked regions on the single crystal. The method also includes performing a plasma etch for removing portions of the unmasked regions of the single crystal, thereby defining a pillar in each unmasked region, and performing a chemical etch on the pillars at a temperature between 1200° C. and 1600° C. for selectively reducing a width of each pillar. | 2022-02-10 |
20220040464 | NANOPATTERNED MEDICAL DEVICE WITH ENHANCED CELLULAR INTERACTION - A medical device for delivering a drug compound through a | 2022-02-10 |
20220040465 | MICRONEEDLE ARRAY ASSEMBLY, DRUG DELIVERY DEVICE AND METHOD FOR ADMINISTERING LIQUID ACROSS A BROAD AREA AT LOW PRESSURE - A uniformity control membrane can be securely engaged against an upstream side of a microneedle array and configured so that resistance to flow through the uniformity control membrane is substantially greater than the resistance to flow through the microneedle array. These differences in flow resistance can facilitate uniform administration of a liquid formulation into the patient's skin across a broad area and at a relatively low pressure, such as by way of capillary action. The administration of the liquid formulation into the patient's skin across the broad area can result from the liquid formulation being administered by way of at least a majority of the microneedles of the microneedle array. | 2022-02-10 |
20220040466 | Microneedle Systems and Apparatus - A medical system. The medical system includes at least one compartment for a fluid, a fluid path and at least one microneedle fluidly connected to the at least one compartment by the fluid path. A medical infusion system is also disclosed. The system includes a wearable housing, at least one non-pressurized compartment for a fluid contained within the housing, at least one fluid path fluidly connected to the at least one compartment and at least one microneedle fluidly connected to the at least one compartment by the fluid path wherein the fluid path extends through the microneedle. | 2022-02-10 |
20220040467 | LINEAR DRIVE FOR PIGMENTATION DEVICES - A linear drive for pigmentation devices, comprising a stator, an air gap which is provided in the stator and is formed so as to be offset in a defined manner, an electric coil within the stator, said coil being designed to produce a concentration of the magnetic flux in the air gap as a result of the coil being energized, an armature which is designed to carry out sliding axial movements in the stator, and a permanent magnet which is captively connected to the armature. | 2022-02-10 |
20220040468 | Tamper Resistant and Medical Connector Device - The tamper resistant medical connector device | 2022-02-10 |
20220040469 | ROTARY ACTIVATED UNIVERSAL CONNECTOR CAP - Universal disinfecting connector, connector or cap can interface with male, female, female stopcock, and female hemodialysis threaded fittings, therefore encompassing an entire spectrum of disinfecting connectors. Disinfecting connector or cap includes a configuration of structural elements that provide a universal rotary cap incorporating rotary-activated interfaces and design features allowing the cap to be configured to selectively present any one of a plurality of connection types, or interfaces, for engaging, coupling, or capping, a corresponding type of a male or a female connector or luer. | 2022-02-10 |
20220040470 | REMOVABLE MECHANICAL CIRCULATORY SUPPORT FOR SHORT TERM USE - Mechanical circulatory supports configured to operate in series with the native heart are disclosed. In an embodiment, an intravascular propeller is installed into the descending aorta and anchored within via an expandable anchoring mechanism. The propeller and anchoring mechanism may be foldable so as to be percutaneously deliverable to the aorta. The propeller may have foldable blades. The blades may be magnetic and may be driven by a concentric electromagnetic stator circumferentially outside the magnetic blades. The stator may be intravascular or may be configured to be installed around the outer circumference of the blood vessel. The support may create a pressure rise between about 20-50 mmHg, and maintain a flow rate of about 5 L/min. The support may have one or more pairs of contra-rotating propellers to modulate the tangential velocity of the blood flow. The support may have static pre-swirlers and or de-swirlers. The support may be optimized to replicate naturally occurring vortex formation within the descending aorta. | 2022-02-10 |
20220040471 | SYSTEMS AND METHODS FOR TRANSSEPTAL DELIVERY OF THERAPEUTIC DEVICES - A system and method used to deliver a percutaneous ventricular assist device (pVAD) or other cardiac therapeutic device to a site within the heart, such as a site at the aortic valve. A flexible device is percutaneously introduced into a vasculature of a patient and positioned to run from a femoral vein, through the heart via a transseptal puncture, and to a femoral artery. The venous-side end of the flexible device is withdrawn out the venous vasculature superior to the heart, and a pVAD is secured to the flexible device. The pVAD is pushed in a distal direction while the arterial-side end of the flexible device is pulled in the proximal direction to advance the pVAD to the target site. A left ventricle redirector aids in orienting the pVAD and preventing migration of the flexible member towards delicate structures of the heart during advancement of the pVAD. | 2022-02-10 |
20220040472 | ANTI-SUCTION BLOOD PUMP INLET - A heart pump assembly includes an impeller blade coupled to a rotor or a drive shaft, a cannula, a distal projection coupled to a distal end of the cannula and a blood inlet having a plurality of apertures. The plurality of apertures is radially oriented and disposed about a circumference of the cannula. The plurality of apertures includes at least a first ring of apertures which are proximal to the distal projection and a second ring of apertures which are proximal of the first ring of apertures. The plurality of apertures can allow the heart pump assembly to continue to function if anatomical structures or tissue become suctioned to a portion of the heart pump. | 2022-02-10 |
20220040473 | NERVE STIMULATION DEVICES AND METHODS FOR TREATING CARDIAC ARRHYTHMIAS - Systems and methods for treating and/or averting cardiac arrhythmias, such as atrial fibrillation, are provided. A device comprises a housing including an energy source, a contact surface and an electrode. The energy source is configured to transmit an electrical impulse to the electrode through the outer skin surface to a vagus nerve of the patient. The electrical impulse comprises bursts of about 2 pulses to about 20 pulses with each of the bursts having a frequency of about 3 Hz to about 100 Hz. The electrical impulse modulates the vagus nerve to treat a cardiac arrhythmia of the patient. A system includes a sensor for detecting a physiological parameter of a patient's heart, such as heart rate variability, and a controller configured to activate the stimulator based on the physiological parameter to cause the stimulator to generate the electrical impulse. | 2022-02-10 |
20220040474 | RING ELECTRODE FOR A MEDICAL DEVICE - One aspect relates to a process for preparing a ring electrode including the steps of a) providing a monolithic metal precursor, wherein the monolithic metal precursor includes an outer tube forming a first cavity of the precursor, and wherein the outer tube has a wall including in one section an inner tube forming a second cavity of the precursor; b) preparing a composite precursor by inserting a first sacrificial core element into the first cavity of the precursor provided in a) and a second sacrificial core element into the second cavity of the precursor provided in a); c) forming the composite precursor obtained in b) to obtain a formed composite having a smaller outer diameter than the composite precursor obtained in b); d) separating a composite disk from the formed composite obtained in c); e) removing the first and the second sacrificial core element from the composite disk obtained in d). | 2022-02-10 |
20220040475 | ELASTIC NEURAL ELECTRODE AND METHOD FOR FABRICATING THE SAME - An elastic neural electrode is provided, having at least one planar metal layer which comprises conductive material and which is placed on an elastomer layer (PDMS), wherein, for reinforcement of the electrode, a high-tensile-strength polymer layer, in particular parylene layer is applied directly onto the at least one metal layer, the high-tensile-strength polymer layer, in particular parylene layer being the outermost layer of the electrode. | 2022-02-10 |
20220040476 | RESORBABLE IMPLANT FOR STIMULATING TISSUE, SYSTEMS INCLUDING SUCH IMPLANT, AND METHODS OF USING - A system for stimulating tissue generally comprises a resorbable implant. The resorbable implant includes a substrate, at least one contact, and a transceiver, wherein the substrate, the at least one contact, and the transceiver are resorbable. The system also includes a controller configured to communicate with the transceiver of the resorbable implant and a power supply connected to the controller. The controller delivers power to the resorbable implant from the power supply. The resorbable implant delivers electrical stimulation to tissue when the resorbable implant receives power. | 2022-02-10 |
20220040477 | MULTICHANNEL IONTOPHORETIC DEVICES FOR DENTAL AND DERMAL APPLICATIONS - An iontophoretic device including a multichannel driver connected to multiple electrodes, a medication reservoir positioned distal to the multiple electrodes and including multiple reservoir chambers, and a resistive barrier material at least partially surrounding one or more of the multiple electrodes and one or more of the multiple reservoir chambers, the resistive barrier material configured to provide a least resistive current flow path running from an active electrode to a tissue contact point most proximal to the active electrode. | 2022-02-10 |
20220040478 | METHOD AND APPARATUS FOR DELIVERY OF THERAPEUTIC AGENTS - Methods and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a subject. The present disclosure comprises apparatus for the controlled administration of the therapeutic agent through an orifice to the subject, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and an electrical signal generator operatively connected to the electrodes. | 2022-02-10 |
20220040479 | WIRELESS IMPLANT FOR MOTOR FUNCTION RECOVERY AFTER SPINAL CORD INJURY - A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant. | 2022-02-10 |
20220040480 | COMPACT AURICULAR STIMULATION DEVICE - Disclosed are nerve stimulation assemblies adapted to apply stimulation signals to a person's nervous system. The assemblies are adapted to apply such signals to nerves terminating on the outer ear of a person, for example, the auricular branch of the vagus nerve. The assemblies comprise an ear canal extension adapted to fit within an ear canal of the person, a housing connected with the extension, and an electrode arm connected with the housing by a connection member. The connection member is adapted to articulate the electrode arm to position the electrode arm relative to the outer ear. An electrode is connected with a distal end of the arm. When the arm is articulated to a selected orientation and the extension is fitted in the ear canal, the electrode is in electrical contact with a portion of the outer ear innervated by a selected peripheral nerve, such as the vagus nerve. | 2022-02-10 |
20220040481 | MAGNET MANAGEMENT MRI COMPATIBILITY - An implantable medical device, including a magnet and a body encompassing the magnet, wherein the implantable medical device includes structural components in the body configured to move away from one another upon initial rotation of the magnet relative to the body when the magnet is subjected to an externally generated magnetic field, thereby limiting rotation of the magnet beyond the initial rotation. | 2022-02-10 |
20220040482 | MODULAR IMPLANT POSITION MANIPULATOR SYSTEM - This document discusses, among other things, systems and methods for device-assisted manipulation of an implant's position in a patient, such as for delivering and positioning a cochlear implant. An exemplary modular system includes an implant position manipulator (IPM) unit reversibly engaging an elongate member of an implant, and a user control device for applying driving force to the IPM unit to regulate the motion of the implant. The system may include sensors providing feedback on the position or the motion of the implant, or the force or friction applied to the implant during the implantation procedure. | 2022-02-10 |
20220040483 | VAGUS NERVE STIMULATION PRE-SCREENING TEST - Diagnostic screening tests that can be used to identify if a patient is a good candidates for an implantable vagus nerve stimulation device. One or more analyte, such as a cytokine or inflammatory molecule, can be measured from a blood sample taken prior to implantation of a vagus nerve stimulator to determine the patient's responsiveness to VNS for treatment of an inflammatory disorder. | 2022-02-10 |
20220040484 | SYSTEMS AND METHODS FOR MANAGING ATRIAL-VENTRICULAR DELAY ADJUSTMENTS - A system and method for managing atrial-ventricular (AV) delay adjustments are provided and includes electrodes configured to be located proximate to an atrial (A) site and at least one of a left bundle branch (LBB) site or a HIS site. An IMD has a header that includes a right atrial (RA) header port, a right ventricular (RV) header port and a left ventricular (LV) header port. The system includes memory configured to store program instructions and one or more processors that, when configured to execute the program instructions measure an AV interval corresponding to an interval between an atrial paced (Ap) event or an atrial sensed (As) event and a sensed ventricular (Vs) event. The system sets a candidate AV delay based on the AV interval and a bundle branch adjustment (BBA) value, measures a QRS characteristic of interest (COI) while utilizing the candidate AV delay in connection with delivering a pacing therapy by the IMD and adjusts the BBA value and reset the candidate AV delay based on the BBA value as adjusted. The system repeats the adjust, reset and measure to obtain a collection of QRS COIs and corresponding candidate AV delays, selects one of the candidate AV delays, that corresponds to a select one of the QRS COIs, as a BBA AV delay and manages the pacing therapy, utilized by the IMD, based on the BBA AV delay. | 2022-02-10 |
20220040485 | IMPLANTABLE LEAD MIGRATION MONITORING USING ECAP - Systems, devices, methods, and techniques are described for using evoked compound action potential (ECAP) signals to monitor lead position and/or detect lead migration. An example system includes sensing circuitry configured to sense an ECAP signal, and processing circuitry. The processing circuitry controls the sensing circuitry to detect, after delivery of an electrical stimulation pulse, a current ECAP signal, and determines one or more characteristics of the current ECAP signal. The processing circuitry also compares the one or more characteristics of the current ECAP signal to corresponding one or more characteristics of a baseline ECAP signal, and determines, based on the comparison, a migration state of the electrodes delivering the electrical stimulation pulse. Additionally, the processing circuitry outputs, based on the migration state, an alert indicative of migration of the electrodes. | 2022-02-10 |
20220040486 | Electrical Stimulation Systems Based on Stimulation-Evoked Responses - Methods and systems for implanting stimulation leads in a patient's brain are disclosed. The methods and systems use sensed evoked resonant neural activity (ERNA) evoked in neural regions of the brain to guide the implantation and positioning of the stimulation lead(s). In addition to providing surgical support during lead implantation, the ERNA information can be used to facilitate stimulation parameter fitting and maintenance of effective therapeutic stimulation. | 2022-02-10 |
20220040487 | AN INTELLIGENTLY, CONTINUOUSLY AND PHYSIOLOGICALLY CONTROLLED PACEMAKER AND METHOD OF OPERATION OF THE SAME - A pacemaker control system includes a pacemaker; a plurality of sensors which are internal to the pacemaker, a plurality of sensors which are external to the pacemaker, a circuit for entering patient reports; and a circuit for using artificial intelligence to process outputs from the plurality sensors internal and external to the pacemaker and from the circuit for entering patient reports, which are collectively identified as a labeled dataset, to reiteratsvely learn a function which determines the labeled dataset most likely to provide optimal pacemaker function for the patient. The means for using artificial intelligence comprises a database of archive outputs from the plurality sensors internal and external to the pacemaker and from the means for entering patient reports for the patient used for optimization of rate modulation to intelligently, continuously and physiologically control the pacemaker. | 2022-02-10 |
20220040488 | SYSTEMS AND METHODS FOR EXTENDING THE LIFE OF AN IMPLANTED PULSE GENERATOR BATTERY - Systems and methods for extending the life of an implanted pulse generator battery are disclosed. A representative method for establishing charge parameters for a battery-powered implantable medical device includes receiving a patient-specific therapy signal parameter and, based at least in part on the patient-specific therapy signal parameter, determining a discharge rate for a battery of the implanted medical device. The method can further include determining a therapy run time, based at least in part on the discharge rate. The method can still further include determining at least one battery charging parameter, based at least in part on the run time. | 2022-02-10 |
20220040489 | SYSTEM AND METHOD FOR TREATING SCAR TISSUE OF A BIOLOGICAL SUBJECT USING RADIO FREQUENCY WAVES AND MANIPULATION - A system and method for treating tissue of a biological subject, including a radio frequency wave generator configured for generating a radio frequency wave at a therapeutically beneficial wavelength, a power supply configured for supplying power to the generator for generation of the wave, a controller configured for setting the wavelength, and a director configured for directing the wave to the tissue to achieve a therapeutically beneficial outcome for the subject. Preferably, the wave generates heat at a therapeutically beneficial temperature. Preferably, the director is configured for directing the wave to the tissue by placement of the director adjacent the tissue and movement of the director across the tissue in alternating general directions applied at various therapeutically beneficial speeds, various therapeutically beneficial distances, and various therapeutically beneficial time intervals within a desired treatment area of the tissue. | 2022-02-10 |
20220040490 | Reagents and methods for cancer treatment using Magnetic particle - Methods, system and reagents to treat cancer using magnetic particle are disclosed. The method comprises giving patient magnetic particle in combination with TLR agonist type composition and optionally later followed by immune check point inhibitor treatment at therapeutical effective amount. The magnetic particle and TLR agonist type composition is given by intratumoural injection. | 2022-02-10 |
20220040491 | Methods and Systems for Non-Invasive Focalized Deep Brain Stimulation - Systems and methods for providing brain stimulation (e.g., deep brain stimulation) are provided. A brain stimulation method includes applying a first magnetic field at a first location external of a brain, the first magnetic field having a waveform of a first frequency. The method further includes applying a second magnetic field at a second location external of the brain, the second magnetic field having a waveform of a second frequency. The second frequency is different from the first frequency such that temporal interference is generated at a focal point internal to the brain. | 2022-02-10 |
20220040492 | BRAIN IMMUNOREGULATION AND INCREASED HUMAN LIFE SPAN THROUGH TRANSCRANIAL ELECTROMAGNETIC TREATMENT - The present disclosure describes a method of regulating (re-balancing) the brain's immune system to decrease occurrence and/or severity of age-related diseases and increase life span. According to the method, an array of electromagnetic emitters are positioned proximal to the subject. An electromagnetic wave generator generates electromagnetic waves at a predetermined set of parameters. In an example of the emitters positioned proximal to the subject's head, the brain's immune function is normalized/rebalanced in an area under the electromagnetic emitters by applying the electromagnetic waves to the subject through the electromagnetic emitters. With either head or body placement of emitters, a rebalancing of the brain's cytokines/immune mediators occurs, which should result in less occurrence or severity of age-related diseases and, thus, increase human life span. Alternatively, electromagnetic treatment may increase human life span through other mechanism(s) or effects that work independent of, or in concert with, a reduced occurrence/severity of age-related diseases. | 2022-02-10 |
20220040493 | Phototherapy Systems, Methods of Using a Phototherapy System, and Methods of Manufacturing a Phototherapy System - Example phototherapy systems, methods of using a phototherapy system, and methods of manufacturing a phototherapy system are described. An example phototherapy system includes a handle and a phototherapy light source. The phototherapy light source is attached to the handle, adapted to emit a light in a therapeutic wavelength, and includes a plasma lamp. The plasma lamp can be disposed between sheets of transparent material, including quartz. The phototherapy light source can be adapted to emit a light in a UVB wavelength between about 300 nanometers and about 320 nanometers and can have an output of between about 15 mW/cm | 2022-02-10 |
20220040494 | ADJUSTABLE ILLUMINATORS AND METHODS FOR PHOTODYNAMIC THERAPY AND DIAGNOSIS - An illuminator for photodynamically diagnosing or treating a surface includes a plurality of panels. The illuminator further includes a plurality of light sources, each mounted to one of the plurality of panels. The plurality of light sources are configured to irradiate the surface with substantially uniform intensity visible light. The illuminator also includes a heat source configured to emit heat to a patient. The heat increases the generation of a photoactivatable agent and thus shortens the time needed to complete photodynamic therapy | 2022-02-10 |
20220040495 | STOMATITIS TREATMENT DEVICE - A stomatitis treatment device which is equipped with a light emitting means inside a housing to enable inflammations on the roof of the mouth and the upper side of the tongue to be treated, and to which a coupling module is attached to allow inflammations occurring on the lower side of the bottom of the mouth, etc. to be treated, is proposed. The stomatitis treatment device allows the roof of the mouth, the tongue, and the bottom of the mouth to be simultaneously irradiated with light for treatment by attaching and detaching the coupling module to and from the housing having the cell regeneration lamp therein, and thus can be used by patients having severe stomatitis with multiple lesions. | 2022-02-10 |
20220040496 | SYSTEMS AND METHODS FOR PREVENTING, MITIGATING, AND/OR TREATING DEMENTIA VIA VISUAL STIMULATION THAT BINDS HIGHER ORDER BRAIN REGIONS, REDUCES NEURODEGENERATION AND NEUROINFLAMMATION, AND IMPROVES COGNITIVE FUNCTION - Devices, systems, and methods for treating dementia or Alzheimer's disease in a subject in need thereof. In one example, chronic visual stimuli having a frequency of about 30 Hz to about 50 Hz, and more specifically about 40 Hz, are non-invasively delivered to the subject to entrain gamma oscillations in multiple brain regions of the subject, including the prefrontal cortex (PFC) and the hippocampus. The entrained gamma oscillations modulate neuronal activity across multiple brain regions (e.g., facilitate functional binding of neural networks at low gamma frequencies) to induce various neuroprotective effects (e.g., amelioration of amyloid plaques and tau hyper-phosphorylation) and reduce neurodegeneration. Neuronal activity mediated by the chronic visual stimuli reduces an immune response in microglia and ameliorates aberrantly modified genes and proteins involved in membrane trafficking, intracellular transport, synaptic function, neuroinflammation and DNA damage response. Behavior modification including enhanced learning and memory is observed. | 2022-02-10 |
20220040497 | INTERNAL ULTRAVIOLET THERAPY - A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separated by a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space. In some examples, the UV light source is configured to emit light with wavelengths with significant intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway. | 2022-02-10 |
20220040498 | METHODS OF INCREASING RESPONSE TO CANCER RADIATION THERAPY - Disclosed herein are methods of increasing response to radiation therapy in subjects afflicted with cancer. In some embodiments, the method comprises reducing the ability of an immune suppressor cell (e.g., MDSC) to migrate to the microenvironment of the cancer. In some embodiments, the method further comprises suppressing the migration of the immune suppressor cell to a non-malignant cell and/or suppressing the malignant transformation of the non-malignant cells. | 2022-02-10 |
20220040499 | BIODEGRADABLE ADHESIVE WITH RADIOISOTOPES - A radioactive biodegradable adhesive system can include a first component and a second component. The second component can include a radioactive material. The first component and the second component are configured to polymerize to form a radioactive bolus. A method for treating a patient in need of brachytherapy can include providing the radioactive biodegradable adhesive system. The first component and the second component can be applied to a predetermined location to form the radioactive bolus at the predetermined location. | 2022-02-10 |
20220040500 | SYSTEM AND METHOD FOR PASSIVE ION RADIOTHERAPY TREATMENT PLANNING AND DELIVERY - A method of generating a radiotherapy plan for ion therapy, wherein the beam ( | 2022-02-10 |
20220040501 | METHOD AND SYSTEM OF EVALUATING A RADIATION THERAPY TREATMENT PLAN - A method of evaluating a radiation therapy (RT) treatment plan for a treatment volume, divided into sub-volumes and having a target volume and one or more organs at risk, OAR. It includes obtaining a RT treatment plan; calculating the linear energy transfer, LET, in each sub-volume; dividing the dose distribution into doses of a first category and a second category in each sub-volume, wherein the first category comprises doses with energy depositions with an LET below a first LET threshold and the second category comprises doses with energy depositions with an LET above a second LET threshold; determining amounts of doses of the first and of the second category in each sub-volume; and performing an analysis of the quality of the RT treatment plan by metrics based on the obtained distribution of doses of the first and of the second category in the target volume and in the OAR. | 2022-02-10 |
20220040502 | DEVICES AND METHODS FOR ENDOLUMINAL DELIVERY OF EITHER FLUID OR ENERGY FOR DENERVATION - Described herein are methods and devices for selectively applying either fluids (e.g., anesthetics, nerve-blockers, etc.) or energy, such as radiofrequency or ultrasound energy, to a target tissue from within a blood vessel while minimizing the amount of fluid or energy applied to non-target tissue. The catheters described herein may include an elongate body, a directional injector, and one or more holdfasts for securing the catheter. In addition, catheters can include energy applying features for delivering energy to the target tissue. | 2022-02-10 |
20220040503 | ENERGY BASED FAT REDUCTION - Systems and methods for non-invasive fat reduction can include targeting a region of interest below a surface of skin, which contains fat and delivering ultrasound energy to the region of interest. The ultrasound energy generates a thermal lesion with said ultrasound energy on a fat cell. The lesion can create an opening in the surface of the fat cell, which allows the draining of a fluid out of the fat cell and through the opening. In addition, by applying ultrasound energy to fat cells to increase the temperature to between 43 degrees and 49 degrees, cell apoptosis can be realized, thereby resulting in reduction of fat. | 2022-02-10 |
20220040504 | ELECTRICAL CONTROL SYSTEMS FOR POWERED AIR-PURIFYING RESPIRATORS - This disclosure describes electrical control and power supply systems for powered air-purifying respirators (PAPRs). An exemplary electrical control system for a PAPR may be adapted to control the supply of power between a battery and a blower motor of a filtration unit of the PAPR. The electrical control system may include a plurality of integrated circuits that are capable of meeting minimum operating times while balancing power usage of various “off-the-shelf” components of the filtration unit. | 2022-02-10 |
20220040505 | MODULAR PORTABLE MULTI-CREW LIFE SUPPORT SYSTEM - A modular, multi-crew life support system and a method of assembling the system involve a fan to draw in ambient air. The system includes one or more assemblies that produce conditioned air from the ambient air, and a housing to support an oxygen source. The system also includes a port configured as an inlet from the oxygen source to augment the conditioned air, and a duct to disperse a result of augmenting the conditioned air as output air to support two or more occupants of an enclosure. | 2022-02-10 |
20220040506 | Mask Device with Improved Comfort, Airflow, Humidity, and Temperature Characteristics and Providing a Means for Conducting Facial Exercises - The present application describes a mask, configured to be worn on a face of an individual, that has a porous mask frame made of a polymer, one or more fans positioned on the porous mask frame, a mask covering made of one or more layers of non-woven fabric, an energy source in electrical communication with the one or more fans and positioned on at least one of the mask frame or the mask covering. Alternatively, there one or more fans may be positioned on the masking covering without the aid of the mask frame. | 2022-02-10 |
20220040507 | SYSTEMS AND METHODS FOR AUTOMATED RESPIRATOR - There is provided a computing device comprising: at least one processor; and a memory comprising instructions that, when executed by the at least one processor, cause the at least one processor to: receive data indicative of a gas characteristic in a sealed space formed by a face of the wearer and a negative pressure reusable respirator; determine performance of a respirator seal check by the wearer; determine that the negative pressure reusable respirator is being worn by a wearer; perform one or more actions in response to determining that the respirator is being worn by the wearer and the wearer has not performed a respirator seal check that satisfies one or more safety rules; and alter the one or more actions in response to determining that the negative pressure reusable respirator is being worn by the wearer and the wearer has performed a respirator seal check that satisfies one or more safety rules. There is also provided a system using such computing device. | 2022-02-10 |
20220040508 | WEARABLE AIR CLEANING DEVICE - Filtered, clean air can be provided via a personalized airflow to a user, to reduce inhalation of unwanted particles, bioaerosoles, and the like, while providing greater comfort than passive PPE. Various systems and methods are disclosed herein, for filtering and cleaning air via a smart, wearable device. For example, a headset in accordance with this disclosure can detect unwanted particulate matter, harmful compounds, bioaerosols, and other ambient conditions, and dynamically adjust an airflow to form an airshield that is distributed over a user's nose and mouth so as to reduce inhalation of contaminated air by as much as 70%. Various embodiments may utilize filters, disinfection modules, pressure sensors, movement sensors, ambient sensors, and contaminant sensors housed within wearable, portable devices. | 2022-02-10 |
20220040509 | LOCKING MANIFOLD FOR CHEMICAL OXYGEN GENERATOR - A manifold for a chemical oxygen generator (COG) includes a locating plate configured to interface with a COG and a plenum body rotatably attached to the locking plate. The plenum body has an inlet for receiving oxygen and at least one output port in pneumatic communication with the inlet. The manifold includes a lock for immobilizing the plenum body with respect to the locating plate in at least a first position. In another aspect, a COG is provided. The COG may have a housing and a locking manifold. | 2022-02-10 |
20220040510 | WEB HARNESS SYSTEM WITH LEG COMPONENTS - A web harness system includes a web harness belt. The web harness belt including: multiple layers, and a first elastomer layer portion and a second elastomer portion that each connected to a ballistic material layer of the multiple layers. A webbing is connected through the web harness belt. The webbing forms a leg harness portion that includes: a first leg extension connected to a rear lower web support element, a second leg extension is connected to the rear lower web support element; a right leg adjustment belt is connected to the rear lower web support element and a first right leg extension element; and a left leg adjustment belt is connected to the rear lower web support element and a first left leg extension element. | 2022-02-10 |
20220040511 | SELF-SEALING MULTI-SEGMENT RETRACTABLE FIRE CURTAIN - A multi-curtain assembly includes: first and second curtain segments, each having a leading edge and side edge; an edge fastener having first and second fastener portions proximate the side edge of the first and second curtain segments, respectively, the first fastener portion of the first curtain segment being connectable to the second fastener portion of the second curtain segment to produce a seam as the curtain segments are moved to their closed positions; a motor driving one or more of the barrel assemblies; a synchronizing mechanism synchronizing the barrel assemblies. An overlap fastener, arranged proximate edges of the curtain segments in an overlap region, has aligning portions that align as the side edges are brought into alignment by the edge fastener, to mask at least one side of the fastener seam as the fastener portions are connected to each other. | 2022-02-10 |
20220040512 | METHOD AND AQUEOUS COMPOSITION FOR PREVENTING WILDFIRE - The present application provides a method for preventing wildfire in a target, the method comprising providing an aqueous composition comprising fire retardant and fibrillar cellulose and applying the aqueous composition to the target. The present application also provides an aqueous composition comprising fire retardant and fibrillar cellulose, and a container comprising the aqueous composition. The present application also provides use of the aqueous composition for preventing wildfire. | 2022-02-10 |
20220040513 | FIREFIGHTING FLUID STORAGE DEVICE, BATTERY PACK, AND ELECTRIC VEHICLE - An electric vehicle, a battery pack, and a firefighting fluid storage device are disclosed, which relate to the technical field of energy storage devices. The firefighting fluid storage device includes: a box body, where the box body includes an inner cavity and a fluid outlet, the inner cavity is configured to accommodate a firefighting fluid, and the fluid outlet communicates with the inner cavity; and a gas generation component, where the gas generation component is mounted to the box body and configured to release a gas to the inner cavity. When the gas generation component releases the gas, the firefighting fluid moves toward the fluid outlet under the action of the gas. | 2022-02-10 |