06th week of 2022 patent applcation highlights part 27 |
Patent application number | Title | Published |
20220041916 | Cross-linked plugging agent stimulated by high density brine and preparing method thereof - The present invention disclosed a cross-linked plugging agent stimulated by high density brine which comprises: main agent: 21 wt %-53 wt %, gelling agent: 0.5 wt %-9 wt % and pure water; wherein the saline solution is selected from the group consisting of a Dipotassium phosphate (K | 2022-02-10 |
20220041917 | POLYMER DISPERSIONS FOR WAX INHIBITION DURING STIMULATION TREATMENT - The present invention relates to a method of inhibiting or control wax formation during stimulation treatment of a well. More specifically, the present invention proposes the use of aqueous polymer dispersions suitable as wax inhibitor compositions which are compatible with aqueous fracturing fluids. | 2022-02-10 |
20220041918 | SCALE INHIBITION USING BRANCHED POLYMERS - Disclosed herein is a method for inhibiting scale comprising adding to a fluid that causes scale formation a polycarboxylic acid having a polymer backbone and a plurality of branches from the polymer backbone. | 2022-02-10 |
20220041919 | Biochemical Viscosity Reducer For Heavy Oil And Preparation Method Thereof - A biochemical viscosity reducer for heavy oil and a preparation method thereof. The viscosity reducer includes: | 2022-02-10 |
20220041920 | COMPOSITION OF ORGANIC GEL FORMULATIONS FOR ISOLATION OF HIGH TEMPERATURE AND SALINITY PETROLEUM RESERVOIR ZONES - This disclosure relates to an organic gel formulation composition for blocking fluids in naturally fractured carbonate reservoirs, for salinity conditions up to 31,870.50 ppm of total dissolved solids and temperatures up to 120° C., that is, for the purpose temporarily isolating areas of the reservoirs, that will be treated with chemical and radioactive products to quantify the oil remaining in them, the stability of the gel is controlled in a certain period of time, through the synergic effect of the supramolecular interaction between the components of the gel formulation. A disclosed composition may include 0.3 to 1% by weight of a copolymer of acrylamide butyl tertiary of sulfonic acid and acrylamide, and 0.12 to 0.4% by weight of phenol and from 0.18 to 0.6% by weight of hexamethylenetetramine. | 2022-02-10 |
20220041921 | COMPOSITIONS AND METHODS FOR CONTROLLED DELIVERY OF ACID USING SULFONATE DERIVATIVES - The present application relates to compositions and methods for controlled delivery of acid to a desired location, for instance to a subterranean formation. | 2022-02-10 |
20220041922 | METHODS FOR DELAYING IN SITU ACID GENERATION - Provided herein are methods and compositions for delayed in-situ generation of acids. | 2022-02-10 |
20220041923 | HEAT-SENSITIVE RECORDING MATERIAL - Described are colour developers of formula (I) Ar | 2022-02-10 |
20220041924 | THE PROCESS FOR OBTAINING OF FLUORALKYLATED CARBON QUANTUM DOTS - The invention discloses a simple, scalable and convenient solvothermal method of obtaining fluoralkylated carbon quantum dots—Fluocar® Nano materials, by solvothermal pyrolysis of an organic substance in the presence of fluoroorganic substance that contain fluoroalkyl groups. The obtained material is water- and organic solvents soluble, grafted fluorine is hydrolytically stable, and obtained dots having intense luminescence in a wide range of wavelengths, from blue to NIR. Photoluminescent (PL) spectral map of obtained carbon dots solution is highly sensitive to pH changes and rare earth metal ions concentration in this solution. Also PL-map of such material is sensitive to organic complex moiety (e.g. Acidum salicylicum, and penicillinum). | 2022-02-10 |
20220041925 | LIGHT UPCONVERSION MICROCAPSULE SHELLS - A composition, method, and article of manufacture are disclosed. The microcapsule includes a polymer shell encapsulating a core component. The polymer shell includes light upconversion molecules. The article of manufacture includes the microcapsule. The method includes obtaining light upconversion molecules having sidechains with reactive functional groups, and forming a microcapsule. The microcapsule includes a polymer shell encapsulating a core component. The polymer shell includes light upconversion molecules. The article of manufacture includes the microcapsule. | 2022-02-10 |
20220041926 | Ultrabright Lanthanide-Doped Nanoparticles - An upconversion single molecule probe is provided that includes a core having a nanoparticle seed crystal, where the nanoparticle seed crystal is an upconversion seed crystal, a first shell enveloping the core, and a second shell enveloping the first shell. | 2022-02-10 |
20220041927 | SULFIDE PHOSPHOR AND LIGHT-EMITTING DEVICE COMPRISING THE SAME - The present invention relates to a sulfide phosphor including a parent body containing one or more selected from Ba, Li, and S, and Al and Ga as constituent elements, wherein one or more activators selected from Eu and Ce are employed to the parent body. | 2022-02-10 |
20220041928 | MULTIPLEXED SPECTRAL LIFETIME DETECTION OF PHOSPHORS - New methods and assays for multiplexed detection of analytes using phosphors that are uniform in morphology, size, and composition based on their unique optical lifetime signatures are described herein. The described assays and methods can be used for imaging or detection of multiple unique chemical or biological markers simultaneously in a single assay readout. | 2022-02-10 |
20220041929 | LIGHT-EMITTING BODY, METHOD FOR PRODUCING LIGHT-EMITTING BODY, AND BIOLOGICAL MATERIAL LABELING AGENT - A dispersion that includes water and a light-emitting body dispersed in the water. The light-emitting body contains a nanoparticle of a AgInSe compound semiconductor, and a film to which hydrophilicity is imparted by ultrasonic irradiation on a surface of the nanoparticle. The film has a double structure having a first organic molecular film containing an alkylthiol and a second organic molecular film composed mainly of a fatty acid. The light-emitting body has an emission quantum yield of 10% or more, an emission intensity peak wavelength in the range of 650 to 1000 nm, and a half-width ΔH of 100 nm or less at the emission intensity peak wavelength. | 2022-02-10 |
20220041930 | QUANTUM DOTS AND DEVICES INCLUDING THE SAME - A cadmium free quantum dot including a core including a first semiconductor nanocrystal, and a semiconductor nanocrystal shell disposed on the core, a composition of the semiconductor nanocrystal shell being different from a composition of the first semiconductor nanocrystal, a production method thereof, and a device including the same are disclosed. The semiconductor nanocrystal shell includes a zinc chalcogenide, the zinc chalcogenide includes selenium, tellurium, sulfur, or a combination thereof, and the quantum dot further alkaline an alkaline earth metal. | 2022-02-10 |
20220041931 | Silicon Etching Liquid - An etching solution contains a quaternary ammonium compound as a main component, by which an etching rate for silicon is improved, no adhered substances are formed on an etching surface during etching, and the etching rate does not decrease even after continuous use for a long time. The silicon etching solution contains a phenol compound represented by the following Formula (1), a quaternary ammonium compound, and water, and has a pH of 12.5 or more. | 2022-02-10 |
20220041932 | LOW DIELECTRIC RESIN COMPOSITION, MOLDED ARTICLE, FILM, MULTILAYER FILM AND FLEXIBLE PRINTED WIRING BOARD - The present disclosure provides a low dielectric resin composition having good melt processability and excellent low dielectric characteristics in a high frequency band as compared to low dielectric materials such as liquid crystal polymers. A molded article and a film, each of which is formed from the low dielectric resin composition, a multilayer film obtained by superposing a metal foil on at least one main surface of the film, and a flexible printed wiring board which includes the film are also provided. The present disclosure includes, as a low dielectric resin composition, a resin composition which contains (A) a liquid crystal polymer and (B) a graft-modified polyolefin having a polar group. The low dielectric resin composition has a dielectric constant of 2.80 or less at a frequency of 10 GHz and a dielectric loss tangent of 0.0025 or less at a frequency of 10 GHz. | 2022-02-10 |
20220041933 | LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTAL DISPLAY ELEMENT AND LIQUID CRYSTAL DISPLAY - The invention relates to a liquid crystal composition, a liquid crystal display element and a liquid crystal display comprising the liquid crystal composition, belonging to the field of liquid crystal display. The liquid crystal composition of the present disclosure comprises a compound of formula I and one or more compounds of formula II. The liquid crystal composition can increase the dielectric anisotropy and improve the voltage retention rate. | 2022-02-10 |
20220041934 | METHOD FOR PREPARING NEEDLE COKE FOR ULTRA-HIGH POWER (UHP) ELECTRODES FROM HEAVY OIL - A method for preparing needle coke for ultra-high power (UHP) electrodes from heavy oil is provided. In this method, heavy oil is used as a raw material. The size exclusion chromatography (SEC) is conducted with polystyrene (PS) as a packing material to separate out specific components with a relative molecular weight of 400 to 1,000. The ion-exchange chromatography (IEC) is conducted to remove acidic and alkaline components to obtain a neutral raw material. The neutral raw material is subjected to two-stage consecutive carbonization to obtain green coke, and the green coke is subjected to high-temperature calcination to obtain the needle coke for UHP electrodes. The needle coke has a true density of more than 2.13 g/cm | 2022-02-10 |
20220041935 | Process for Production of Graphite Coke from an Admixture of Coal and Petroleum Based Hydrocarbons - The present invention provides a process for production of graphite coke from an admixture of coal and petroleum-based hydrocarbons. This particularly describes a process wherein a mixture of coal tar pitch and hydrocarbon feedstock such as CLO is purified in a solvent treatment step and the purified mixed feedstock is subjected to thermal cracking to produce high quality graphite/needle coke. This process also provides a synergy in improved coke quality coke formation while using an admixture of coal tar pitch and CLO while subjected to common purification and coking steps. | 2022-02-10 |
20220041936 | HYDROCARBON STREAM SEPARATION SYSTEM AND METHOD - A system and method for separating a hydrocarbon feed stream by flashing the feed stream under vacuum to form a remaining flashed vapor comprising atmospheric hydrocarbons, vacuum distillable hydrocarbons and a non-volatile liquid; condensing the flashed vapor to a liquid using a two-stage condenser and heat recovery system; and recycling a portion of the condensed liquid to be flashed under vacuum. Separation is accomplished by combining atmospheric and vacuum separation in one column. The non-volatile liquid recovered from the vacuum vessel may comprise asphalt. This process also injects steam generated within the process into the vacuum vessel which is condensed in a two-stage condenser system to augment vacuum and aid in separation. The feed stream may comprise diluted bitumen which may be removed using a feed preparation vessel. | 2022-02-10 |
20220041937 | PROCESS FOR POLYMER MIXTURE HYDROCONVERSION - There is a process for the hydroconversion of mixtures of polymers or plastics which comprises the pre-treatment of the mixtures through methods selected from mechanical methods, chemical methods, thermal methods, or combinations thereof forming a pre-treated charge. The pre-treated charge is mixed with a hydrocarbon vacuum residue, optionally pre-heated, to form a reactant mixture. The reactant mixture is fed to a hydroconversion section in slurry phase, together with a catalyst precursor containing Molybdenum, and a stream containing hydrogen, forming a reaction effluent. The effluent is separated into at least one high-pressure and high-temperature separator in a vapour phase and a slurry phase. The separate vapour phase is sent to a gas treatment section with the function of separating a liquid fraction from the gas containing hydrogen and hydrocarbon gases having from 1 to 4 carbon atoms; said liquid fraction comprising naphtha, atmospheric gas oil (AGO), vacuum gas oil (VGO). The slurry phase is then sent to a separation section that has the function of separating the fractions of the Vacuum Gas Oil (VGO), Heavy Vacuum Gas Oil (HVGO), Light Vacuum Gas Oil (LVGO), Atmospheric Gas Oil (AGO), from a stream of heavy organic products which contains asphaltenes, unconverted charge, catalyst and solid formed during the hydroconversion reaction. This stream of heavy organic products is partly recirculated to the hydroconversion section and partly forms a purge stream. | 2022-02-10 |
20220041938 | UPGRADING OF LOW VALUE LIPID FEEDSTOCKS FOR REFINERY PROCESSING - A process is provided for upgrading low value lipid feedstocks for refinery processing. The process includes (a) treating a lipid feedstock comprising at least one fatty acid with a metal oxide catalyst on an oxide support under treating conditions to produce a treated stream, wherein the treating conditions include a temperature in a range of from 400° C. to 700° C.; a pressure in a range of from 0 to 10 MPa; and a liquid hourly space velocity in a range of from 0.1 to 10 h | 2022-02-10 |
20220041939 | PROCESS FOR INTEGRATED PRODUCTION OF RENEWABLE FUELS AND CHEMICALS - The present disclosure provides a versatile process for producing valuable renewable hydrocarbons from triglyceride containing feedstock. The triglyceride containing feedstock is first split to provide a mixture containing fatty acids, glycerol and water, from which a phase separation provides an oily phase, and an aqueous phase. The oily phase containing fatty acids is subjected to fractionation, whereby specific fractions may be refined to products with controlled hydroprocessing. Products may contain paraffinic renewable aviation fuel components, paraffinic renewable base oil, renewable paraffinic diesel fuel components, renewable paraffinic technical fluid, or any combination thereof. | 2022-02-10 |
20220041940 | Process For Co-Conversion Of Waste Plastics And Hydrocarbon Feedstock - The present invention relates to a process for converting the waste plastics along with the petroleum feedstock in a Catalytic Cracking Unit, in particular a Fluid Catalytic Cracking Unit employed in petroleum refineries. The invention also provides a method and hardware system to enable waste plastic to fuel conversion along with hydrocarbon catalytic cracking. The invented process aims to convert any type of waste plastic including polystyrene, polypropylene, polyethylene, metal containing Polyethylene-Polypropylene multilayer plastics & other metal containing plastics along with the petroleum derived feedstock such as vacuum gas oil, reduced crude oil, vacuum residue etc. in catalytic cracking unit. | 2022-02-10 |
20220041941 | MEANS AND METHODS FOR MANAGING AMMONIA, AMINE AND NORMAL SALT FOULING IN OIL PRODUCTION AND REFINING - Methods for use in treating hydrocarbon streams are provided. The methods of the present disclosure include; introducing one or more alcohols into a hydrocarbon stream that includes one or more hydrolyzable chloride compounds; allowing the one or more alcohols to interact with, the one or more hydrolyzable chloride compounds; and increasing: one of a solubility value or a dispersancy value of at least a portion of the hydrolyzable chloride compounds in the hydrocarbon steam. | 2022-02-10 |
20220041942 | METHOD FOR HYDROCARBON PRODUCTION, PURIFICATION METHOD, AND PURIFIER - The present invention relates to a method for producing a hydrocarbon, including a step (Y) of converting a reaction product of at least one sulfur compound selected from the group consisting of hydrogen sulfide and a compound containing a —SH group which are contained in a hydrocarbon with an α,β-unsaturated aldehyde compound into a water-soluble compound in the presence of water, and a step (Z) of separating oil and water. | 2022-02-10 |
20220041943 | DEVICE AND PROCESS FOR THE PRODUCTION OF AROMATICS FROM A BIOMASS PYROLYSIS GAS - A device and process for the conversion of aromatic compounds, includes/uses: a unit for the separation of the xylenes suitable for treating a cut comprising xylenes and ethylbenzene and producing an extract comprising para-xylene and a raffinate; an isomerization unit suitable for treating the raffinate and producing an isomerate enriched in para-xylene which is sent to a fractionation train; a pyrolysis unit suitable for treating biomass, producing a pyrolysis effluent feeding, at least partially, the feedstock, and producing a pyrolysis gas comprising CO and H | 2022-02-10 |
20220041944 | HYDROGEN SULPHIDE AND MERCAPTANS SCAVENGING COMPOSITIONS - The present invention relates to a composition for scavenging hydrogen sulphide and/or mercaptans in hydrocarbon streams, the composition comprising an oxazolidine compound and a synergistic additive. | 2022-02-10 |
20220041945 | Organomodified polysiloxanes and their use for defoaming fuels - Disclosed are organomodified polysiloxanes, compositions, in particular fuel compositions, that include these organomodified polysiloxanes, and the use of the organomodified polysiloxanes for the defoaming of fuels. | 2022-02-10 |
20220041946 | FUEL ADDITIVE COMPOSITION, FUEL COMPOSITION, AND PROCESS FOR PREPARATION THEREOF - The present disclosure describes an additive composition comprising: (a) an organometallic compound; (b) a nitrogen-containing compound; (c) an aryl peroxide; and (d) at least one solvent, wherein the organometallic compound to the nitrogen-containing compound to the aryl peroxide weight ratio is in a range of 7:0.5:0.5-9:1.5:1.5. The addition of additive composition not only synergistically improves the properties of the at least one fuel, such as, LPG for use as torch gas for cutting and welding application, but also reduces the consumption of both fuel and oxygen for cutting applications. The present disclosure is also directed towards a process for preparation of the fuel composition. | 2022-02-10 |
20220041947 | COCONUT SHELL CHARCOAL LOG - A method for fabricating a coconut shell heat producing device. Heat is applied to coconut shells to form carbonized coconut charcoal pieces. The charcoal pieces are ground to form coconut charcoal powder. A moistened blend is created that includes the coconut charcoal powder, a binder and water. The moistened blend is placed into a press. Pressure is applied in the press to form the moistened blend into the heat providing device. The heat providing device includes at least one hole extending through the device. In a preferred embodiment the heat producing device is a coconut shell charcoal log. | 2022-02-10 |
20220041948 | METHOD FOR PRODUCING CHARCOAL - A process for the production of charcoal comprising the steps of: a) feeding biomass, in particular wood chips, into a pyrolysis unit, in which the wood chips are pyrolyzed into a full stream comprising solid, liquid and gaseous material, b) feeding the full stream and a gasifying agent into an oxidation unit, wherein the full stream is oxidized at least partially and transported pneumatically, c) feeding the partially oxidized full stream from the oxidation unit into a reduction unit arranged essentially vertically, the material outlet of the oxidation unit being connected to the reduction unit, with the cross-section of the reduction unit increasing as the distance from the material outlet of the oxidation unit increases, the flow rate of the full stream in the reduction unit being adapted to the material of the full stream and to the shape of the flow cross-section of the reduction unit in such a way that a stable fixed bed kept in suspension is formed in the reduction unit, d) removing the raw charcoal from the reduction unit via an overflow, e) separating gaseous components in a hot gas filter and collecting the charcoal, and f) quenching the collected charcoal with water. | 2022-02-10 |
20220041949 | ANTIOXIDANT MIXTURE FOR HIGH VISCOUS POLYALKYLENE GLYCOL BASESTOCK - The invention relates to a lubricant comprising a polyalkylene glycol basestock, a phenol selected from an ester of 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionic acid with a C | 2022-02-10 |
20220041950 | DURABLE SURFACE COATINGS - Described herein are durable coatings, i.e. for medical devices, and methods of forming the coatings. | 2022-02-10 |
20220041951 | Phosphorylated Dispersants in Fluids for Electric Vehicles - The present disclosure relates to a lubricating fluid for an electric motor system and a method of lubricating gears and cooling a motor in an electric motor system. In particular, the disclosed technology relates to a lubricating fluid, for use in electric motor vehicle, comprising an oil of lubricating viscosity and at least one phosphorylated dispersant exhibiting increased resistivity after aging. | 2022-02-10 |
20220041952 | METHOD OF PREPARING KRILL OIL AND KRILL OIL COMPOSITION - Disclosed is a method of preparing krill oil. A method of preparing krill oil may include providing a dried krill powder; obtaining an extract after adding spirits of wine to the dried krill powder; obtaining a passing solution from which salt and cholesterol are removed by passing the extract through a column; obtaining a krill concentrate by decompression-concentrating the passing solution; and obtaining krill oil by stationarily positioning a mixture obtained by adding spirits of wine to the krill concentrate, layer-separating the stationarily positioned mixture, extracting a supernatant of the layer-separated mixture, and concentrating the extracted supernatant. | 2022-02-10 |
20220041953 | METHOD FOR EXTRACTING AN OIL RICH IN POLYUNSATURATED FATTY ACIDS (PUFA) - The present invention relates to a method for extracting an oil rich in polyunsaturated fatty acids (PUFA), in particular an oil of microorganisms rich in docosahexaenoic acid (DHA, C22:6n3), in particular oils comprising more than 60% of PUFA relative to the total mass of fat. | 2022-02-10 |
20220041954 | PREVENTION OF MCPDE FORMATION IN TRIACYLGLYCERIDE OILS - A method is provided for preventing or reducing the formation of monochloropropanediols (MCPDs) or monochloropropanediol esters (MCPDEs) in triacylglyceride oil, comprising the steps: (a) concentrating insoluble components in liquid triacylglyceride oil by (i) applying a 5 centrifugational force on the triacylglyceride oil whilst maintaining the triacylglyceride oil above its melting temperature; and/or (ii) allowing the insoluble components to settle by gravitational force whilst maintaining the triacylglyceride oil above its melting temperature; (b) separating the triacylglyceride oil from the insoluble components; (c) optionally applying additional refining steps and (d) applying heat treatment to the triacylglyceride oil. A purified 10 triacylglyceride oil obtainable by the method of the invention is also provided. | 2022-02-10 |
20220041955 | CARBOXYLIC ACID ESTER COMPOUND, PRODUCTION METHOD THEREOF, AND FRAGRANCE COMPOSITION - The present invention has an object of providing a carboxylate compound that is useful as a raw material for fragrance compositions and has a fruity aroma, a method for producing the same, and a fragrance composition containing the carboxylate compound. | 2022-02-10 |
20220041956 | SAMPLER FOR A SCENTED WAXY CANDLE AND PROCESS - A sampler is presented for a sample of a scented, waxy candle material. The scented, waxy material is melted and may be diluted with compatible additives and/or liquid (organic oil or hydrocarbon), before being layered to a face of a bottom layer. A top layer ( | 2022-02-10 |
20220041957 | GLUCAMIDE-BASED SURFACTANTS - An N-acylglucamide compound of the formula (I) | 2022-02-10 |
20220041958 | CLEANING COMPOSITIONS FOR CLEANING HARD SURFACES - The disclosure provides a cleaning composition for cleaning a hard surface, comprising: a) an oil and/or fat, wherein the oil and/or fat is from 1% to 20% by weight based on a total weight of the composition; b) a polyol; c) a surfactant, wherein a weight ratio of the surfactant to the oil and/or fat is equal to or greater than 1:5. The disclosure further relates to a method of preparing the cleaning composition and uses thereof. | 2022-02-10 |
20220041959 | CONTACT LENS TREATMENT SOLUTION - The present invention is a contact lens treatment solution containing the following copolymer A and copolymer B in a ratio of A/B=40/1 to 5/1 (by weight). According to the present invention, there can be provided a contact lens treatment solution capable of removing dirt having adhered to contact lens surfaces, capable of improving lubricity of contact lens surfaces and capable of imparting persisting hydrophilicity to contact lens surfaces, by simple immersion treatment. | 2022-02-10 |
20220041960 | AMPHIPHILIC POLYSACCHARIDE DERIVATIVES AND COMPOSITIONS COMPRISING SAME - The disclosure relates to compositions comprising a polysaccharide derivative, wherein the polysaccharide derivative comprises a polysaccharide substituted with a) at least one hydrophobic group, and b) at least one hydrophilic group, wherein the polysaccharide is poly alpha-1,3-glucan, poly alpha-1,6-glucan, or poly alpha-1,3-1,6-glucan. | 2022-02-10 |
20220041961 | COMPOSITIONS COMPRISING BENEFIT AGENT CONTAINING DELIVERY PARTICLE - Compositions that include benefit agent delivery particles, the particles having a core and a shell encapsulating the core, the shell including certain acrylate-based polymers. Processes for making and using such compositions. | 2022-02-10 |
20220041962 | SHAPED BODY COMPRISING A POLYETHYLENE GLYCOL GRAFT COPOLYMER AND THE AROMA CHEMICAL - The presently claimed invention relates to a shaped body comprising at least one graft copolymer (I) comprising a polyether and one or more side chains obtained by the polymerization of compounds of formula (IA) and/or formula (IB) and/or formula (IC); CH | 2022-02-10 |
20220041963 | ANALYSIS DEVICE - An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal. | 2022-02-10 |
20220041964 | ALGAE INCUBATOR - A system for algae incubation including a reactor cell adapted to grow algae, a support buoy secured to the reactor cell, and a floating vessel secured to the reactor cell. | 2022-02-10 |
20220041965 | CELL CULTURE SYSTEM - A cell culture system includes a culture bag made of a flexible packaging material and having a plurality of ports, a medium container that stores a medium to be transferred to the culture bag, and a control part that controls the supply of the medium, tubular members are connected to the respective ports to circularly connect the culture bag and the medium container through the tubular members, the tubular member connected to a first port of the plurality of ports is provided with first supply unit (e.g., pump), and the tubular member connected to a second port of the plurality of ports is provided with second supply unit (e.g., pump), and the control part controls the operation of at least the first supply unit or the second supply unit to circulate the medium in the culture bag and the medium container. | 2022-02-10 |
20220041966 | UNIVERSAL MICROFLUIDIC CULTURE SYSTEM TO ANALYZE AND CONTROL CELL DYNAMICS - Microfluidic devices, systems, and methods. | 2022-02-10 |
20220041967 | REAL-TIME MONITORING OF SINGLE CELL OR EVENTS - The present invention relates to methods and devices for monitoring events occurred in a single cell or examining cell characteristics in a single cell in a massive parallel and real-time manner. In one embodiment, the present invention provides a single-cell culturing system for culturing and monitoring a large number of cells independently at single-cell level. In one embodiment, the present invention provides methods and devices for studying or monitoring single-cell response to an external stimulus in a massive parallel and real-time manner. In one embodiment, the present invention provides methods and devices for studying or monitoring drug response at single-cell level in a massive parallel and real-time manner. | 2022-02-10 |
20220041968 | CELL ADHESION COMPOSITION AND CELL ADHESION SUBSTRATE - A cell adhesion composition according to one aspect of the present invention comprises: an amphiphilic compound; and a conjugate of a DNA and a hydrophilic molecule, wherein the amphiphilic compound has a hydrophobic group that can non-covalently bond to a cell membrane, and a hydrophilic group, and wherein a weight-average molecular weight of the hydrophilic molecule of the conjugate is larger than a weight-average molecular weight of a hydrophilic molecule from which the hydrophilic group of the amphiphilic compound derives. According to such a cell adhesion composition, it is possible to impart a cell adhesion ability to a base material at an arbitrary timing by using light having an arbitrary wavelength. | 2022-02-10 |
20220041969 | CELL CULTURE CHIP - The cell culture chip includes a bottom substrate and a base body part. The base body part includes a plurality of first portions for forming the culture space, and a cavity penetrating the base body part in a region where the first portions are not formed. The first portions each include a recessed region and a plurality of opening grooves that are formed through the base body part from a plurality of places inside the recessed region. In the cavity, at least a part of an end is positioned inside an outer edge of the base body part. The bottom substrate and the first surface of the base body part are bonded together to form the culture space in which the recessed region is sandwiched between the bottom substrate and the base body part. | 2022-02-10 |
20220041970 | CELL CULTURE SUBSTRATE MADE OF NONWOVEN FABRIC MANUFACTURED USING ELECTROSPINNING AND METHOD OF MANUFACTURING THE SAME - A cell culture substrate used for growing mesenchymal stem cells (MSC) while maintaining the differentiation potency of the mesenchymal stem cells includes a nonwoven fabric made of resin fibers spun using an electrospinning method. The nonwoven fabric includes a plurality of resin fibers having outer diameters of 10-50 μm. The plurality of resin fibers are intertangled in random directions. A mesh structure is formed by the intertangled plurality of resin fibers adhering and joining together at locations where the resin fibers contact one another. The mesh structure forms mesh openings that have a substantially elliptical shape with a diameter of 100-200 μm and that are surrounded by curved fibers. Innumerable air bubble pores having diameters of 0.1-3 μm are formed over the entire surface of the fibers making up the nonwoven fabric. | 2022-02-10 |
20220041971 | SEPARATION DEVICE AND METHOD FOR SEPARATING TO-BE-SEPARATED MATERIAL USING SAME - A separation device for separating a solid separation target contained in a suspension obtained by suspension culture of adherent cells by using a fine scaffold material, and a separation method. The separation device has a separation chamber having a first chamber and a second chamber, and the first chamber and the second chamber are divided by a mesh structure for separation. The mesh structure for separation has mesh-holes with a predetermined size to suppress passage of the separation target, and a mesh structure for separation is configured in the separation chamber such that the liquid in the aforementioned suspension has a vertically upward directional component in the advancing direction of the liquid when the liquid passes through the mesh-holes. | 2022-02-10 |
20220041972 | METHOD FOR CLEANING A SOLID SUPPORT OF A FERMENTATION REACTOR COMPRISING A CONTAMINATED POLYURETHANE FOAM - The present invention relates to a process for cleaning a solid support of a fermentation reactor for the production of alcohols by fermentation using a sugary fluid, the solid support comprising a polyurethane foam inoculated with a biomass produced by a solvent-producing strain belonging to the genus | 2022-02-10 |
20220041973 | INTEGRATED CAPSULE SYSTEM FOR REAL-TIME BIOPROCESS MONITORING AND METHOD OF USING THE SAME - An apparatus for monitoring a bioprocess parameter. The apparatus includes: a housing; a bioprocess sensor attached to an outer surface of the housing; a power supply contained within the housing; and an electronics module contained within the housing and in communication with the power supply and the sensor, where the electronics module includes a wireless communication unit. | 2022-02-10 |
20220041974 | SYSTEMS AND METHODS FOR HOLISTIC LOW CARBON INTENSITY FUEL AND ETHANOL PRODUCTION - Systems and methods to provide low carbon intensity (CI) ethanol through one or more targeted reductions of carbon emissions based upon an analysis of carbon emissions associated with a combination of various options for feedstock procurement, feedstock refining, processing, or transformation, and ethanol distribution pathways to end users. Such options are selected to maintain the total CI (carbon emissions per unit energy) of the ethanol below a pre-selected threshold that defines an upper limit of CI for the ethanol. | 2022-02-10 |
20220041975 | System and Method for Creating Tissue - A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue. | 2022-02-10 |
20220041976 | SEPARATION DEVICES, ASSOCIATED METHODS, AND SYSTEMS - A system for isolating a target molecule from a bioprocess fluid includes a single-use disposable separation device having a plurality of perimeter-bonded layers defining one or more mesofluidic channels of the separation device, wherein each layer includes a biocompatible polymer material, wherein the separation device is configured to separate at least a portion of particles from the bioprocess fluid to generate a substantially clarified bioprocess fluid, and a chromatography system fluidically coupled at the outflow of the separation device in a configuration for further processing the clarified bioprocess fluid. | 2022-02-10 |
20220041977 | MATRIX-MEDIATED CELL CULTURE SYSTEM - The invention relates to a matrix-mediated algal cell culture system comprising a porous matrix, a microalgal cell culture comprising cells immobilised on the porous matrix, and a vector including a nucleic acid sequence encoding a heterologous polypeptide of interest, wherein immobilisation of microalgal cells on the porous matrix results in the formation of interstitial spaces between the microalgal cells to allow for increased contact of the microalgal cells with the vector compared with a culture of microalgal cells which are not immobilised on a porous matrix, thereby allowing for more efficient transfection of the microalgal cells with the vector. The invention also relates to methods of screening single species of microalgae and mixed ecology samples for the ability to be transfected using the algal cell culture system, and to methods for the production of heterologous polypeptides using the matrix-mediated cell culture system. | 2022-02-10 |
20220041978 | METASTABLE STATE MIXING - Metastable state spore incubation mixing systems are described. An example system includes a spore container to store spores, a nutrient container, an arrangement of valves and tubes, a reciprocating pump, a mixing tube, and a holding tank. In a drawing phase of the system, a controller can control the reciprocating pump to draw a ratioed volume of the spores, the nutrients, and water through the valves and tubes. During an expelling phase of the system, the controller can control flow control valves to direct the spores, nutrients, and water through the mixing tube and into the holding tank. The controller can also direct a heater to heat the mixture in the holding tank to a predetermined temperature. Once the mixture reaches the temperature, the controller can also direct the system through a number of other phases of operation, including cooling and purging phases. | 2022-02-10 |
20220041979 | LARGE SCALE CELL CULTURE SYSTEM FOR MAKING MEAT AND ASSOCIATED PRODUCTS - Provided is a large-scale cell culture system for producing products without harming animals. Also provided is a method for making meat products using this cell culture system. Further provided is a method for making personal care products using this cell culture system, as well as a method for making nutritional supplements using this cell culture system. | 2022-02-10 |
20220041980 | MAINTENANCE OF DIFFERENTIATED CELLS WITH LAMININS - The present disclosure describes methods of maintaining the phenotype of differentiated cells. Generally, the natural environment of the body is replicated for the differentiated cell. The differentiated cell is plated on a cell culture substrate comprising a laminin, such as laminin-521 or laminin-511. The substrate may also contain a cadherin. This maintains the phenotype of the differentiated cell. | 2022-02-10 |
20220041981 | MULTIPOTENT ADULT STEM CELLS: CHARACTERIZATION AND USE - The present invention relates to biomarkers, methods, and compositions for characterizing and isolating multipotent adult stem cells (MASCs) and uses thereof. | 2022-02-10 |
20220041982 | A SERUM-FREE COMPLETE MEDIUM FOR INDUCING DIFFERENTIATION OF A MESENCHYMAL STEM CELL TO A CORNEAL EPITHELIAL CELL - A serum-free complete medium for inducing differentiation of a mesenchymal stem cell to a corneal epithelial cell in the field of differentiation induction of stem cells, prepared by the following method: uniformly mixing the serum-free complete medium, containing 5-10 μmol of resveratrol, 2-4 μmol of icariin, 1-3 nmol of aspirin, 1-3 nmol of parathyroid hormone, 5-10 nmol of hydrocortisone, 1-3 mg of rapamycin, 2-10 μg of testosterone, 2-10 μg of EPO, 2-10 μg of LIF and the balance of a corneal epithelial cell serum-free medium in per 1 L; and then performing sterilization by filtration. The disclosure uses resveratrol and icariin in combination with aspirin, parathyroid hormone, hydrocortisone, rapamycin, testosterone and growth factors to cooperatively induce directional differentiation, uses nontoxic induction components, is high in induction efficiency and short in induction time, and achieves high induced corneal epithelial cell activity, no cell transplantation rejection, no ethical problem and high safety. | 2022-02-10 |
20220041983 | Hair Follicle Germs, Method for Producing Hair Follicle Germs, and Method for Activating Cells Included in Hair Follicle Germs - Provided are a hair follicle germ having excellent hair growth-related properties, a method of producing a hair follicle germ, and a method of activating cells contained in a hair follicle germ. The hair follicle germ includes: epithelial cells; mesenchymal cells; and mesenchymal stem cells. The method of producing a hair follicle germ includes co-culturing epithelial cells, mesenchymal cells, and mesenchymal stem cells to form a hair follicle germ. | 2022-02-10 |
20220041984 | MOBILIZED PERIPHERAL BLOOD AS A SOURCE OF MODIFIED IMMUNE CELLS - The present invention relates to compositions and methods of generating sources of immune cells and/or stem cells for cell therapy. One aspect of the invention includes a method of generating an immune cell to be modified into an immune cell comprising a chimeric antigen receptor (CAR). Another aspect of the invention includes a method of generating cells, such as immune cells and/or stem cells, for autologous or allogeneic cell therapy. Also included are methods and pharmaceutical compositions comprising the cells for adoptive therapy and treating a condition, such as an autoimmune disease or cancer. | 2022-02-10 |
20220041985 | Methods for Preparing Therapeutically Active Cells Using Microfluidics - The present invention is directed to the use of microfluidics in the preparation of cells and compositions for therapeutic uses. | 2022-02-10 |
20220041986 | Truncated Epiderimal Growth Factor Receptor (EGFRt) for Transduced T Cell Selection - A non-immunogenic selection epitope may be generated by removing certain amino acid sequences of the protein. For example, a gene encoding a truncated human epidermal growth factor receptor polypeptide (EGFRt) that lacks the membrane distal EGF-binding domain and the cytoplasmic signaling tail, but retains an extracellular epitope recognized by an anti-EGFR antibody is provided. Cells may be genetically modified to express EGFRt and then purified without the immunoactivity that would accompany the use of full-length EGFR immunoactivity. Through flow cytometric analysis, EGFRt was successfully utilized as an in vivo tracking marker for genetically modified human T cell engraftment in mice. Furthermore, EGFRt was demonstrated to have cellular depletion potential through cetuximab mediated antibody dependent cellular cytotoxicity (ADCC) pathways. Thus, EGFRt may be used as a non-immunogenic selection tool, tracking marker, a depletion tool or a suicide gene for genetically modified cells having therapeutic potential. | 2022-02-10 |
20220041987 | GENETICALLY-MODIFIED IMMUNE CELLS COMPRISING A MICRORNA-ADAPTED SHRNA (SHRNAMIR) - The present invention encompasses genetically-modified immune cells (and populations thereof) expressing a microRNA-adapted shRNA (shRNAmiR) that reduces the expression of a target endogenous protein. Methods for reducing the expression of an endogenous protein in an immune cell are also provided wherein the method comprises introducing a shRNAmiR that targets the endogenous protein. Using shRNAmiRs for knocking down the expression of a target protein allows for stable knockdown of expression of endogenous proteins in immune cells. | 2022-02-10 |
20220041988 | GENERATION OF FUNCTIONAL AND PATIENT-SPECIFIC THYMIC TISSUE IN VIVO FROM INDUCED PLURIPOTENT STEM CELLS - The disclosed technology includes methods, systems, and devices for generating patient-specific functional thymic epithelial progenitor (TEP) cells. In some implementations, a method may include generating iPSCs from HSC; causing differentiation of the iPSC into thymic epithelial progenitor (TEP) cells, generating thymic epithelial cells by transplantation of the TEP cells into a host, wherein the TEP cells may differentiate into mature functional thymic epithelial cells (TECs). In some implementations, a system may include a cell population of patient specific cells, a population of iPSCs, a culture system for differentiating the iPSCs into a population of patient-specific TEP cells for transfer to a host or the patient to allow the TEP cells to differentiate into mature, functional TEC. | 2022-02-10 |
20220041989 | CELLULAR CULTURE MEDIUM FREE FROM SERUM - The present invention relates to a cell culture medium, in particular for culturing autologous fibroblasts, for use in aesthetic medicine for skin transplantation, said culture medium being serum-free and being characterized in that it contains glucose in a much lower quantity than conventional culture media. | 2022-02-10 |
20220041990 | METHODS, COMPOSITIONS, AND KITS FOR PRODUCING SKELETAL MUSCLE STEM CELLS AND TREATING DISORDERS - Provided herein are, inter alia, are methods, compositions and kits for producing populations of myogenic progenitor cells, and compositions comprising the cell populations derived thereof. Also included are methods and compositions for treating or preventing a muscle disease or disorder in a subject (e.g., Duchenne muscular dystrophy (DMD). | 2022-02-10 |
20220041991 | CELL STRUCTURE INCLUDING SMALL INTESTINAL EPITHELIAL CELLS, METHOD FOR PRODUCING SAME, AND SUBSTRATE HOLDING SAME - The method for producing a cell construct including small intestinal epithelial cells includes: seeding stem cells onto cell culture substrate, the cell culture substrate having surface including cell culture part, wherein the cell culture part includes non-cell-adhesive part, and cell-adhesive part extending continuously or intermittently along periphery of the non-cell-adhesive part and surrounding the non-cell-adhesive part; and culturing the stem cells seeded to differentiate a part of the stem cells into small intestinal epithelial cells. | 2022-02-10 |
20220041992 | Methods and Compositions for the Clinical Derivation of an Allogenic Cell and Therapeutic Uses - Various cells, stem cells, and stem cell components, including associated methods of generating and using such cells are provided. In one aspect, for example, an isolated cell that is capable of self-renewal and culture expansion and is obtained from a subepithelial layer of a mammalian umbilical cord tissue. Such an isolated cell expresses at least three cell markers selected from CD29, CD73, CD90, CD166, SSEA4, CD9, CD44, CD146, or CD105, and does not express at least three cell markers selected from CD45, CD34, CD14, CD79, CD106, CD86, CD80, CD19, CD117, Stro-1, or HLA-DR. | 2022-02-10 |
20220041993 | THREE-DIMENSIONAL TISSUE CONSTRUCT AND METHOD FOR PRODUCING SAME, AND METHOD FOR PRODUCING CELL-CONTAINING COMPOSITION - The present invention relates to a method for producing a three-dimensional tissue construct, the method comprising:
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20220041994 | METHODS TO PRESERVE TUMOR-STROMAL INTERACTIONS IN CULTURE AND THERAPEUTIC PREDICTIVE APPLICATIONS THEREOF - Functional in vitro assays are provided for determining patient specific responsiveness to immunotherapy agents within a clinically actionable time frame. | 2022-02-10 |
20220041995 | SELECTION METHOD OF iPS CELL, PREPARATION METHOD OF iPS CELL, AND CONTROL DEVICE - A selection method of an iPS cell includes: at a reprogramming process to culture a cell including a plurality of combinations of initializing factors labelled with luminescent genes that are different with each other, acquiring a photon number per unit area or a photon number per unit time of each of the luminescent genes of the cell; judging whether the acquired photon number is more than a threshold that is predetermined for the acquired photon number; and when the acquired photon number is more than the threshold, selecting this cell as an objective cell for a next process. | 2022-02-10 |
20220041996 | PERSONALIZED CELLS, TISSUES, AND ORGANS FOR TRANSPLANTATION FROM A HUMANIZED, BESPOKE, DESIGNATED-PATHOGEN FREE, (NON-HUMAN) DONOR AND METHODS AND PRODUCTS RELATING TO SAME - A biological system for generating and preserving a repository of personalized, humanized transplantable cells, tissues, and organs for transplantation, wherein the biological system is biologically active and metabolically active, the biological system having genetically reprogrammed cells, tissues, and organs in a non-human animal for transplantation into a human recipient, wherein the non-human animal does not present one or more surface glycan epitopes and specific sequences from the wild-type swine's SLA is replaced with a synthetic nucleotides based on a human captured reference sequence from a human recipient's HLA. | 2022-02-10 |
20220041997 | Method for rescuing influenza virus and composition therefor - The present invention relates to a new method for rescuing an influenza virus and a composition therefor. The method comprises providing a host cell stably integrated with and expressing influenza virus PA, PB1, PB2 and NP genes, and introducing an influenza virus rescue system in which a stop codon is introduced into the PA, PB1, PB2 and NP genes respectively into the host cell to achieve virus rescue. The produced virus particles can be used as a live attenuated influenza vaccine, which is characterized in that, since the genes encoding the related proteins are mutated, it has no replication and proliferation ability in human and normal animal cells, and replication and proliferation can be achieved only in the host cells constructed above and it can fully stimulate the body immunity and effectively protect the body while ensuring the safety. | 2022-02-10 |
20220041998 | Process And Microorganism For Synthesis Of Adipic Acid From Carboxylic Acids - A method for biosynthesis of polymer precursors, including, adipic acid, 1,6-hexanediol, 6-hydroxyhexanoic and 6-aminocaproic acids from carboxylic acids is provided. A method for biosynthesis of adipic acid from six-carbon dicarboxylic acids having α, β-enoate reductase activity by treatment with an enzyme is provided. The biocatalytic conversion of aliphatic and hydroxycarboxylic acids to corresponding aldehydes, alcohols, and amines using novel carboxylate reductases, aldehyde reductases, and aminotransferases is described. Also provided are genetically engineered microorganisms for use in the biosynthetic processes. | 2022-02-10 |
20220041999 | METHODS TO ENRICH GENETICALLY ENGINEERED T CELLS - Various embodiments are disclosed herein relate to methods for selection of a genetically engineered cell. Some embodiments relate to a cell that is produced with the methods disclosed herein. | 2022-02-10 |
20220042000 | METHODS FOR PREPARING N-ACETYL-L-METHIONINE - The present disclosure relates to a polypeptide having an acyltransferase activity or a microorganism including the same; a composition for preparing N-acetyl-L-methionine, the composition including the polypeptide or microorganism; and a method of preparing N-acetyl-L-methionine using the polypeptide or microorganism. Further, the present disclosure relates to a polynucleotide encoding the polypeptide and an expression vector including the polynucleotide. Since the microorganism including a novel acyltransferase according to the present disclosure has enhanced acyltransferase activity, this microorganism can be efficiently used for producing N-acetyl-L-methionine by acetylating L-methionine. | 2022-02-10 |
20220042001 | IMPROVED HUMAN METHYLTHIOADENOSINE/ADENOSINE DEPLETING ENZYME VARIANTS FOR CANCER THERAPY - Disclosed herein are compositions related to conjugated polypeptides with MTA/ADO-degrading enzyme activity. The conjugated polypeptides are engineered to allow for maximal conjugation while maintaining catalytic activities. Also disclosed are nucleic acids, expression vectors, and host cells related to the conjugated polypeptides. Further disclosed are methods of using the pharmaceutical formulations comprising above to treat cancer. | 2022-02-10 |
20220042002 | ENGINEERED HUMAN EXTRACELLULAR DNASE ENZYMES - The present disclosure provides a library of engineered DNASE proteins (including DNASE1, DNASE1-LIKE 1, DNASE1-LIKE 2, DNASE1-LIKE 3, DNASE2A, DNASE2B) that allows to select drug candidates for developing therapeutics for treating conditions characterized by neutrophil extracellular trap (NET) accumulation and/or release. In accordance with the invention, the selected DNase variant has improved properties, including properties amenable to clinical development, including manufacturing, toxicology, pharmacokinetic, and/or use in therapy. | 2022-02-10 |
20220042003 | Polypeptides Having Alpha-Amylase Activity And Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having alpha-amylase activity, catalytic domains, carbohydrate binding domains and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding domains. | 2022-02-10 |
20220042004 | PENICILLIN-G ACYLASES - The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes. | 2022-02-10 |
20220042005 | METHOD OF PREPARING AN ORGANIC-INORGANIC HYBRID NANOFLOWER - The technical field of enzyme immobilization, and particularly, an organic-inorganic hybrid nanoflower and a preparation method thereof. The organic-inorganic hybrid nanoflower is a flower-like immobilized enzyme formed by self-assembly of a layered rare earth compound as an inorganic carrier and a biological enzyme as an organic component. The layered rare earth compound is Ln | 2022-02-10 |
20220042006 | ADENOVIRUS LIBRARY AND METHODS - Described herein is a method that generally includes infecting a host cell with a rescue adenovirus, wherein the rescue adenovirus genome comprises a loxP site and encodes at least one marker, and wherein the host cell comprises a library of polynucleotides that complement the adenovirus genome marker and encode a detectable polypeptide; incubating the infected host cell under conditions effective to permit recombination between the adenovirus genome and one or more of the library polynucleotides and the production of recombinant adenovirus particles comprising at least on detectable polypeptide; and detecting the at least one detectable polypeptide. Also described are adenovirus libraries constructed using such a method. | 2022-02-10 |
20220042007 | TRANSPOSON END COMPOSITIONS AND METHODS FOR MODIFYING NUCLEIC ACIDS - The present invention provides methods, compositions and kits for using a transposase and a transposon end for generating extensive fragmentation and 5′-tagging of double-stranded target DNA in vitro, then using a DNA polymerase for generating 5′- and 3′-tagged single-stranded DNA fragments without performing a PCR amplification reaction, wherein the first tag on the 5′-ends exhibits the sequence of the transferred transposon end and optionally, an additional arbitrary sequence, and the second tag on the 3′-ends exhibits a different sequence from the sequence exhibited by the first tag. The method is useful for generating 5′- and 3′-tagged DNA fragments for use in a variety of processes, including processes for metagenomic analysis of DNA in environmental samples, copy number variation (CNV) analysis of DNA, and comparative genomic sequencing (CGS), including massively parallel DNA sequencing (so-called “next generation sequencing”). | 2022-02-10 |
20220042008 | COMPOSITIONS OF STREPTAVIDIN-OLIGO CONJUGATES OF pMHC OCCUPANCY - The present disclosure describes pMHC multimer species barcoded with different nucleic acid molecules and the use thereof to determine both the antigen responsiveness and TCR avidity in biological samples and to sequence corresponding T cell transcriptome, T cell proteome, T cell epigenome or the TCR loci. | 2022-02-10 |
20220042009 | SYSTEMS AND METHODS FOR NUCLEIC ACID PREPARATION - The present disclosure provides methods and systems for nucleic acid processing. A method for preparing a sequencing set may include providing a template nucleic acid and amplifying the template nucleic acid to provide a complementary nucleic acid. Next, the complementary nucleic acid may be fragmented and barcoded to produce a first set of barcoded fragments comprising a plurality of first barcoded fragments. Next, the plurality of first barcoded fragments may be fragmented to yield a second set of barcoded fragments comprising a plurality of second barcoded fragments. | 2022-02-10 |
20220042010 | METHODS FOR DETERMINING INCREASED RISK OF CANCER DEVELOPMENT AND TREATING THE SAME - The present invention is directed to a method for treating cancer in a subject determined as having the presence of a G | 2022-02-10 |
20220042011 | ANTISENSE OLIGONUCLEOTIDES TARGETING CARD9 - The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to CARD9 pre-mRNA intron and exon sequences, which are capable of inhibiting the expression of CARD9 protein. Inhibition of CARD9 expression is beneficial for a range of medical disorders including inflammatory bowel disease, pancreatitis, IgA nephropathy, primary sclerosing cholangitis, cardiovascular disease, cancer and diabetes. | 2022-02-10 |
20220042012 | INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN, ACID LABILE SUBUNIT (IGFALS) AND INSULIN-LIKE GROWTH FACTOR 1 (IGF-1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF - The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the insulin-like growth factor binding protein, acid labile subunit (IGFALS) gene or the insulin-like growth factor 1 (IGF-1) gene, methods of using such double stranded RNAi agents to inhibit expression of an IGFALS gene or an IGF-1 gene, and methods of treating subjects having an IGF system-associated disorder. | 2022-02-10 |
20220042013 | COMPOSITIONS AND THEIR USES DIRECTED TO HUNTINGTIN - Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing Huntington's Disease (HD) progression using an antisense compound targeted to huntingtin. Additionally provided are methods of delaying or preventing the onset of Huntington's Disease (HD) in an individual susceptible to Huntington's Disease (HD). Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. | 2022-02-10 |
20220042014 | APOLIPOPROTEIN C3 (APOC3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF - The present invention relates to RNAi agents, e.g., double stranded RNA (dsRNA) agents, targeting the apolipoprotein C3 gene (APOC3). The invention also relates to methods of using such RNAi agents to inhibit expression of an APOC3 gene and to methods of preventing and treating an APOC3-associated disorder, e.g., hypertriglyceridemia, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, polycystic ovary syndrome, kidney disease, obesity, type 2 diabetes mellitus (insulin resistance), hypertension, artherosclerosis and pancreatitis. | 2022-02-10 |
20220042015 | CONJUGATED OLIGONUCLEOTIDES FOR TISSUE SPECIFIC DELIVERY - Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution with enhanced in vivo silencing efficacy. | 2022-02-10 |