06th week of 2022 patent applcation highlights part 37 |
Patent application number | Title | Published |
20220042916 | RAMAN SPECTROSCOPY METHOD AND APPARATUS - Apparatus and methods for acquiring a Raman spectral map of a sample including a material species. The apparatus includes: a pulsed illumination source providing pulsed illumination radiation for exciting the sample and producing scattered radiation; a microscope objective focusing the pulsed illumination radiation onto a region of the sample corresponding to a data point of the map, and collecting emitted radiation from the region; a translation stage translating the sample relative to the microscope objective in at least two directions; a spectral filter spectrally filtering the emitted radiation collected by the objective to obtain a filtered portion of radiation corresponding to a characteristic Raman spectral feature of the material species; a detector receiving the filtered portion and providing output electrical pulses indicative thereof; and readout electronics applying a time gate to the output electrical pulses to distinguish detection events corresponding to the Raman scattered radiation from events associated with photoluminescence. | 2022-02-10 |
20220042917 | REMOTE-EXCITATION TIP-ENHANCED RAMAN SPECTROSCOPY (TERS) PROBE FOR NANOSCALE TERS IMAGING - A method is disclosed for spatial resolution tip-enhanced Raman spectroscopy (TERS) imaging. The method includes physically separating a light excitation region from a Raman signal generation region on a remote-excitation tip-enhanced Raman spectroscopy (RE-TERS) probe. Also disclosed is a method of fabricating a remote-excitation tip-enhanced Raman spectroscopy (TERS) probe, and a system for spatial resolution tip-enhanced Raman spectroscopy (TERS) imaging. The system includes an atomic force microscopy-tip-enhanced Raman spectroscopy (AFM-TERS) system having a RE-TERS probe having a conical tip tapering to a silver nanowire tip (AgNW tip), a silver nanocrystal (AgNC) attached to a side wall of a nanowire, a laser configured to propagate excited surface plasmon polaritons (SPPs) along the nanowire, the nanowire (NW) configured to generate compressed excited surface plasmon polaritons (SPPs), and wherein the conical tip of the nanowire is configured to generate a nano-sized hot spot at a tip apex for TERS excitation. | 2022-02-10 |
20220042918 | CHARACTERISTIC INFORMATION EXTRACTION METHOD, AND RAPID DETECTION METHOD AND SYSTEM OF ORGANIC POLLUTANTS IN COMPLEX SYSTEM - A method for fast extracting an organic pollutant in a complex system is disclosed, which includes following steps. A surface-enhanced Raman scattering (SERS) spectrum of an organic pollutant is divided to obtain P wavelength sub-intervals with overlapping regions. The P wavelength sub-intervals are screened to obtain ω wavelength sub-intervals. The ω wavelength sub-intervals are screened to obtain a required wavelength sub-interval. The required wavelength sub-interval is screened to obtain a required wavelength subset. A method and a system for fast detecting an organic pollutant in a complex system are also disclosed. | 2022-02-10 |
20220042919 | OPTOFLUIDIC DIAGNOSTICS SYSTEM - An optofluidic diagnostic system and methods for rapid analyte detections. The system comprises an optofluidic sensor array, a test plate and an optical detection cartridge. The sensor array supports one or more distinct sensor units, each having a reactor section designed to temporarily enter a series of different kinds of wells in the test plate. One kind of well is a sample reservoir that holds reagent solution to be transferred into the reactor section. Another kind of well is a drainage chamber that removes reagent solution from the reactor section. A third kind of well is a colorant reservoir that holds a colorant reagent transferable into a reactor section. Finally, the sensor unit is transferred to the optical detection cartridge where it is placed into an isolation booth during the optical detection process so that its flat observation face is stationed in a viewing window opposite an optical detector lens. | 2022-02-10 |
20220042920 | BIOSENSORS BASED ON OPTICAL PROBING AND SENSING - Apparatus, sensor chips and techniques for optical sensing of substances by using optical sensors on sensor chips. | 2022-02-10 |
20220042921 | FLUID TEST DEVICE AND MODULE - Embodiments for local and safe testing of injection fluids by drawing a sample of injection fluid into a local test chamber while drawing fluid to be tested into a syringe assembly and testing the sample of the injection fluid are disclosed. A fluid test device can include a syringe assembly, a plunger assembly, and a test module. The test module can determine information about fluid in a syringe assembly when the fluid enters a test chamber in the test module. Fluid may enter the test chamber through a one-way valve while a plunger in the plunger assembly is moved in a suction stroke to draw fluid into an interior of the syringe assembly. Fluid may not enter or be expelled from the test chamber when the plunger does not move or is moved in a compression stroke to expel fluid from the syringe assembly. | 2022-02-10 |
20220042922 | Inspection Compliance Validation System - An inspection compliance validation system for a truck includes a plurality of indicators and a reader. Each indicator is coupled to a vehicle proximate to a respective inspection site of the vehicle and is operationally coupled to an electronic logging device of the vehicle. The electronic logging device is positioned to selectively actuate the indicator to notify a user of an inspection status for an associated inspection site. The reader is configured to receive a signal from a respective indicator corresponding to the inspection status of the associated inspection site and to relay the signal to the electronic logging device to validate that an inspection has been performed. | 2022-02-10 |
20220042923 | STRUCTURED ILLUMINATION OPTICAL INSPECTION PLATFORM FOR TRANSPARENT MATERIALS - A method of imaging surface features with a large (non-microscopic) field-of-view includes projecting a structured illumination pattern onto the transparent target. The surface features modify the structured illumination pattern, and an image of the modified structured illumination pattern is imaged at each of multiple different introduced phase shifts via an imaging device. The method further provides for extracting, from each of the captured phase-shifted images, image components that correspond to frequencies exceeding a cutoff frequency of the imaging device; and using the extracted image components to construct a corrected image of the surface features of the transparent target. The corrected image has a resolution that is greater than a spatially incoherent point-to-point optical resolution of the imaging device. | 2022-02-10 |
20220042924 | DEFECT IDENTIFICATION USING MACHINE LEARNING IN AN ADDITIVE MANUFACTURING SYSTEM - An additive manufacturing system comprises an apparatus arranged to distribute layer of metallic powder across a build plane and a power source arranged to emit a beam of energy at the build plane and fuse the metallic powder into a portion of a part. The system includes a processor configured to steer the beam of energy across the build plane and receive data generated by one or more sensors that detect electromagnetic energy emitted from the build plane when the beam of energy fuses the metallic powder. The received data is converted into one or more parameters that indicate one or more conditions at the build plane while the beam of energy fuses the metallic powder. The one or more parameters are used as input into a machine learning algorithm to detect one or more defects in the fused metallic powder. | 2022-02-10 |
20220042925 | SYSTEM FOR ASCERTAINING OPTICAL CHARACTERISTICS OF GEMSTONE | 2022-02-10 |
20220042926 | MICROSTRIP-TYPE MICROWAVE SENSOR - A microstrip-type microwave sensor for the measurement of the dielectric properties of a solid or liquid material, constituted by a main line and two connected transmission lines integral at one of their extremities to the main line, the main line and two connected transmission lines being spaced from one another by a slot and being made integral with a substrate. The main line is connected to an electrical circuit by each of its two extremities to inject a sinusoidal signal, and wherein said main line has a width giving it an impedance in the range 50 Ohm, the two connected transmission lines being of the same width and of a length equal to one quarter of the wavelength guided in the substrate, the substrate having a height or thickness giving it flexibility or rigidity, the substrate being applied to a metallic support formed of a layer of metallic material. | 2022-02-10 |
20220042927 | ABSORPTION IMAGING APPARATUS AND DETECTOR ARRAY THEREFOR | 2022-02-10 |
20220042928 | X-RAY SINGLE-PIXEL CAMERA BASED ON X-RAY COMPUTATIONAL CORRELATED IMAGING - An X-ray single-pixel camera based on X-ray computational correlated imaging, which belongs to the technical research fields of X-ray computational correlated imaging and X-ray single-pixel imaging. The X-ray single-pixel camera includes: an X-ray modulation system ( | 2022-02-10 |
20220042929 | CT SYSTEM AND DETECTION DEVICE FOR CT SYSTEM - The present application discloses a CT system and a detection apparatus for the CT system. The detection apparatus includes: a high-energy detector assembly including a plurality of rows of high-energy detectors arranged along a predetermined trajectory; a low-energy detector assembly including a plurality of rows of low-energy detectors arranged at intervals along the predetermined trajectory, the low-energy detector assembly and the high-energy detector assembly being disposed in a stack; a number of rows of the low-energy detectors is smaller than a number or rows of the high-energy detectors; and each row of the low-energy detectors covers a row of high-energy detectors. | 2022-02-10 |
20220042930 | PART INSPECTION METHOD USING COMPUTED TOMOGRAPHY - A system and method of inspecting a plurality of objects using a computed tomography (CT) system is provided. The method includes acquiring an image of a fixture used for holding the plurality of objects with the CT system. A first electronic model of the fixture is generated. The objects are placed in the fixture. An image of the fixture and the objects is acquired with the CT system. A second electronic model of the fixture and the objects is generated. A third electronic model of the objects is defined based at least in part on subtracting the first electronic model from the second electronic model. Dimensions of the objects from the third electronic model are compared with a computer aided design (CAD) model. A report is output based at least in part on the comparison of the objects from the third electronic model with the CAD model. | 2022-02-10 |
20220042931 | INDUSTRIAL TOMOGRAPHY APPARATUS AND METHOD FOR CHECKING THE COMPOSITION OF INDUSTRIAL PRODUCTS WHICH COMPRISE A PLURALITY OF PRIMARY PARTS - An industrial tomography apparatus ( | 2022-02-10 |
20220042932 | Estimating Background Radiation from Unknown Sources - Embodiments include a method, comprising: receiving measured radiation obtained from a radiation detector that received radiation through an object; simulating the measured radiation obtained from the radiation detector that received radiation through the object; generating an offset based on the measured radiation and the simulated measured radiation; estimating scatter radiation based on the offset; and estimating primary radiation based on the estimated scatter radiation | 2022-02-10 |
20220042933 | Small-Angle X-Ray Scatterometry - A method for evaluating an array of high aspect ratio (HAR) structures on a sample includes illuminating the sample with an x-ray beam along a first axis parallel to within two degrees to the HAR structures in the array and sensing a first pattern of small angle x-ray scattering (SAXS) scattered from the sample while illuminating the sample along the first axis. The sample is illuminated with the x-ray beam along a second axis that is oblique to the HAR structures in the array, and a second pattern of the SAXS scattered from the sample is sensed while illuminating the sample along the second axis. Information is extracted with respect to the HAR structures based on the first and second patterns. | 2022-02-10 |
20220042934 | X-RAY BASED MEASUREMENTS IN PATTERNED STRUCTURE - A method and system are presented for use in X-ray based measurements on patterned structures. The method comprises: processing data indicative of measured signals corresponding to detected radiation response of a patterned structure to incident X-ray radiation, and subtracting from said data an effective measured signals substantially free of background noise, said effective measured signals being formed of radiation components of reflected diffraction orders such that model based interpretation of the effective measured signals enables determination of one or more parameters of the patterned structure, wherein said processing comprises: analyzing the measured signals and extracting therefrom a background signal corresponding to the background noise; and applying a filtering procedure to the measured signals to subtract therefrom signal corresponding to the background signal, resulting in the effective measured signal. | 2022-02-10 |
20220042935 | METHOD AND APPARATUS FOR MONITORING BEAM PROFILE AND POWER - A system and a method for monitoring a beam in an inspection system are provided. The system includes an image sensor configured to collect a sequence of images of a beam spot of a beam formed on a surface, each image of the sequence of images having been collected at a different exposure time of the image sensor, and a controller configured to combine the sequence of images to obtain a beam profile of the beam. | 2022-02-10 |
20220042936 | IMAGE PROCESSING SYSTEM - Provided is an image processing system capable of estimating a three-dimensional shape of a semiconductor pattern or a particle by solving problems of measurement reduction in a height direction and taking an enormous amount of time at a time of acquiring learning data. The image processing system according to the disclosure stores a detectable range of a detector provided in a charged particle beam device in a storage device in advance, generates a simulated image of a three-dimensional shape pattern using the detectable range, and learns a relationship between the simulated image and the three-dimensional shape pattern in advance. | 2022-02-10 |
20220042937 | METHOD AND SYSTEM FOR DETECTING AND CONTROLLING LONG-RANGE QUANTUM COHERENCE OF MOLECULAR INTERACTIONS - The present disclosure provides a method and system for detecting and controlling the long-range quantum coherence of molecular interactions, e.g., hydrogen bonds, with an electrical current or electromagnetic field, e.g., in a low end of radio frequency range at room temperature. The resonant frequencies of molecular interactions such as hydrogen bonds may be detected and the long-range quantum coherence of the molecular interactions such as hydrogen bonds may be controlled with electrical current or electromagnetic fields. | 2022-02-10 |
20220042938 | SYSTEM AND METHOD FOR HAND-HELD NQR-BASED IN-FIELD SCREENING OF SUBSTANCES - An exemplary integrated nuclear quadrupole resonance-based detection system comprises a front-end device having a hand-held form factor, wherein the front-end device is configured to scan a sample in or near a sample coil using inbuild electronics and acquire a nuclear quadrupole resonance measurement. The system further includes a swappable sample coil that is attached to an opening at a face of the front-end device and is tuned to a resonant frequency of the sample; and a swappable impedance matching network that is attached to the opening at the face of the front-end device and is configured to tune the resonant frequency of the sample coil. The inbuild electronics comprises a wireless transfer module that is configured to communicate the acquired nuclear quadrupole resonance measurement with a back-end device of the integrated nuclear quadrupole resonance-based detection system. Other systems and methods are also provided. | 2022-02-10 |
20220042939 | METHOD AND DEVICE FOR SENSORY MEASUREMENT OF A MATERIAL SAMPLE - In association with a method and a device for sensory measurement of a material sample, a measurement curve is used to detect deviations from the regular measuring characteristics of the device. A corresponding file can be made available to a service technician for evaluation. | 2022-02-10 |
20220042940 | CHECKING METHODS AND SYSTEMS FOR CHECKING A MECHANICAL PIECE MANUFACTURED BY USING A MOLD AND A MANUFACTURING PROCESS IN A FOUNDRY - The checking methods includes the steps of feeding molten metal into the mold ( | 2022-02-10 |
20220042941 | HETEROSTRUCTURE SEMICONDUCTOR, CHEMIRESISTIVE GAS SENSOR MADE THEREOF, AND METHOD OF FABRICATION THEREOF - An example heterostructure semiconductor for sensing a gas comprises a substrate made of nanosheets of a compound of a first metal, wherein the compound of the first metal is sensitive to the gas to be sensed; one or more 1-Dimensional (1D) components fabricated on a surface of the substrate, the 1D components comprising a compound of a second metal, wherein the compound of the second metal is selective to the gas to be sensed; and a 2-Dimensional (2D) layer formed on the surface of the substrate in portions excluding the 1D components, wherein the 2D layer comprises compounds of the first and second metal. Method of fabrication of the heterostructure semiconductor and a chemiresistive sensor made thereof are also disclosed. | 2022-02-10 |
20220042942 | SYSTEMS AND METHODS FOR CONTROLLING OXYGEN LEVELS - Sensors are configured to capture measurement data representing dissolved oxygen (DO) measurements of an environment and capacitance measurements of a medium of the environment. A memory includes computer-executable instructions. One or more processors are communicatively coupled to the one or more sensors and configured to execute the computer-executable instructions to carry out operations comprising: generating, using first measurement data captured by the one or more sensors, a model based on a relationship between the first set of DO measurements and the first set of capacitance measurements; receiving, from the one or more sensors, second measurement data; predicting, using the model and based on the new capacitance measurement, an expected DO measurement; determining whether to use the expected DO measurement or the new DO measurement; and controlling, a valve to cause the determined oxygen input amount to flow into the environment based on the expected DO measurement. | 2022-02-10 |
20220042943 | METHODS AND APPARATUS FOR MEASURING ANALYTES - Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions. | 2022-02-10 |
20220042944 | NANOCHANNEL SYSTEMS AND METHODS FOR DETECTING PATHOGENS USING SAME - A method of detecting a pathogen uses a 3D nanochannel device having top and bottom chambers, and a plurality of nanochannels. The method also includes functionalizing a nanochannel by coupling an oligonucleotide probe to an inner surface thereof. The method further includes adding a lysis buffer and patient sample to the top chamber. Moreover, the method includes extracting an oligonucleotide from the patient sample. In addition, the method includes placing top and bottom electrodes in the top and bottom chambers respectively and applying an electrophoretic bias therethrough. The method also includes applying a selection bias across first and second gating nanoelectrodes to direct flow of the oligonucleotide through the nanochannel. Moreover, the method includes applying a sensing bias through a sensing nanoelectrode. In addition, the method includes detecting an output current from the sensing nanoelectrode, and analyzing the output current from the sensing nanoelectrode to detect the oligonucleotide. | 2022-02-10 |
20220042945 | ELECTROPHORESIS DEVICE CAPABLE OF CARRYING OUT ELECTROPHORESIS ON PLURALITY OF SAMPLES INDEPENDENTLY - Aiming at achievement of timely installation of the cartridge, sequential execution of the pretreatment process in the order of installation of the cartridge, and individual shifting of the process to the electrophoresis process upon completion of the pretreatment process, the electrophoresis device according to the present invention includes a plurality of capillaries each filled with a separation medium, a thermostat chamber for holding the capillaries at a predetermined temperature, an irradiation detector which executes light irradiation and detection in an electrophoresis process using the capillaries, a high voltage power supply unit for voltage application to the capillaries, a liquid feeding mechanism for feeding the separation medium to the capillaries, and an autosampler for conveying containers each holding a reagent or a sample to the capillary. The voltage application to the capillaries by the high voltage power supply unit is controlled for each of the capillaries. | 2022-02-10 |
20220042946 | USING ELECTROPHORESIS FOR DISEASE DETECTION BASED ON CONTROLLED MOLECULAR CHARGE - Electrophoresis is used to identify presence of a target compound in a patient sample based on a charge state of the compound and a label. The charge state of the compound correlates to a total net charge of a binder conjugated to the compound. The bound complex or “bound complex” with the label is then applied to the electrophoresis substrate. An electric potential is applied to the substrate for a time period and causes the labeled bound complex to migrate toward the electrode with opposite charge of the labeled bound complex at a migration velocity to form a migration pattern over the time period. At some time during or at the end of the time period, the labeled bound complex produces a bound complex band as a result of its migration across the substrate. The presence of the compound is identified based on the labeled bound complex band and one or both of the migration pattern and the migration velocity. | 2022-02-10 |
20220042947 | ENDOTOXIN DETECTION DEVICE AND ENDOTOXIN DETECTION METHOD - Provided are a device and a method for rapidly and simply detecting endotoxin without using an expensive reagent. The endotoxin detection device includes: a region containing an electrolyte solution; a partitioning member that partitions the region into two compartments such that the two compartments are in communication via a nanopore; a first electrode that is disposed in a first compartment; a second electrode that is disposed in a second compartment and is electrically connected to the first electrode; an electrolyte solution flow generating means that causes electrolyte solution in the first compartment to move to the second compartment via the nanopore; an application means that applies voltage between the first electrode and the second electrode; and a monitoring means that monitors current. | 2022-02-10 |
20220042948 | GAS ANALYZER APPARATUS AND METHOD FOR CONTROLLING GAS ANALYZER APPARATUS - There is provided a gas analyzer apparatus that analyzes inflowing sample gas. The gas analyzer apparatus includes a filter unit that filters the sample gas, a detector unit that detects the result of filtering, a housing that houses these elements, and a control unit that controls the respective potentials of these elements. The control unit includes a cleaning control unit that sets the respective potentials of the filter unit, the detector unit, and the housing to cleaning potentials that draws in, as plasma for cleaning purposes, process plasma from a source that supplies the sample gas or plasma generated by a plasma generation unit. | 2022-02-10 |
20220042949 | Substance Detection Element - A through hole ( | 2022-02-10 |
20220042950 | System for Providing Power to a Stationary Underwater Control Station - Ultrasonic transmitting elements in an electroacoustical transceiver transmit acoustic energy to an electroacoustical transponder, which includes ultrasonic receiving elements to convert the acoustic energy into electrical power for the purposes of powering one or more sensors that are electrically coupled to the electroacoustical transponder. The electroacoustical transponder transmits data collected by the sensor(s) back to the electroacoustical transceiver wirelessly, such as through impedance modulation or electromagnetic waves. A feedback control loop can be used to adjust system parameters so that the electroacoustical transponder operates at an impedance minimum. An implementation of the system can be used to collect data in a vehicle, such as the tire air pressure. Another implementation of the system can be used to collect data in remote locations, such as in pipes, enclosures, in wells, or in bodies of water. | 2022-02-10 |
20220042951 | METHOD FOR RECONSTRUCTING A THREE-DIMENSIONAL SURFACE USING AN ULTRASONIC MATRIX SENSOR - A method for reconstructing a three-dimensional surface of a part using an ultrasonic matrix sensor including scanning the three-dimensional surface using a matrix sensor at different measurement points located at the intersection of scanning rows and of increment rows at each measurement point, acquiring a temporal row image representing a reflected wave amplitude received by each element from a selected row of the matrix sensor and acquiring a temporal column image representing a reflected wave amplitude received by each element from a selected column of the matrix sensor, constructing a two-dimensional row image for each scanning row on the basis of the temporal row images constructing a two-dimensional column image for each increment row on the basis of the temporal column images, and constructing a three-dimensional image on the basis of the two dimensional row images and of the two-dimensional column images. | 2022-02-10 |
20220042952 | STATE ESTIMATION DEVICE AND STATE ESTIMATION METHOD - A state estimation device calculates a state transition table indicating a state transition assumed in an object every time a connection pattern between partial waveforms is changed, selects a connection pattern from the state transition table on the basis of entropy that is a statistical index of the state transition of the object, and estimates a state of the object at each time and a state transition of the object on the basis of the selected connection pattern. | 2022-02-10 |
20220042953 | SYSTEM AND METHOD FOR REDUCING MOISTURE TO SAMPLE AND TEST A GAS MIXTURE - A system for analyzing a gas mixture is provided. The system includes an enclosure inlet. A moisture trap assembly is coupled to the enclosure inlet. The moisture trap assembly removes excess moisture from a sample at the enclosure inlet. A testing section is coupled to the moisture trap assembly for detecting one or more compounds from the sample. | 2022-02-10 |
20220042954 | METHODS OF MEASURING HYDROPHOBICITY OF CHROMATOGRAPHIC RESINS - In certain embodiments, the present invention provides a method of measuring the level of hydrophobicity of a chromatographic resin. In certain embodiments, the present invention provides a method of selecting a chromatographic resin condition for purifying a protein of interest from a mixture, wherein the protein of interest has low or no aggregation formation during chromatography. In certain embodiments, the present invention provides a method of selecting a chromatographic resin from a plurality of chromatographic resins for purifying a protein of interest from a mixture, wherein the protein of interest has low or no aggregation formation during chromatography. | 2022-02-10 |
20220042955 | PEPTIDE MARKERS FOR AUTHENTICATING EJIAO AND RELATED GELATINS - Provided herein is a method for authenticating animal hide gelatins using peptide markers found animal hide gelatin hydrolysates. The method can be used to authenticate animal hide gelatins derived from donkey hide, horse hide, pig hide, and cattle hide. | 2022-02-10 |
20220042956 | SPECTROPHOTOMETER - A spectrophotometer ( | 2022-02-10 |
20220042957 | Peak Profile for Identifying an Analyte in a Chromatogram - A method of determining an identity of a first analyte in a sample is described that includes passing the first analyte through a chromatographic column and detecting a signal curve of the first analyte by a chromatographic detector, wherein the signal curve includes a peak profile of the first analyte. The peak profile is defined by a plurality of measured data points configured to plot onto a signal coordinate system. The method further includes normalizing the peak profile of the first analyte to form a normalized peak profile, wherein the normalized peak profile includes scaling the plurality of measured data points, and wherein the normalized peak profile is defined by a plurality of normalized data points configured to plot onto a normalized coordinate system, and comparing the normalized peak profile of the first analyte with a normalized peak profile of a second analyte. | 2022-02-10 |
20220042958 | CAPACITIVE HYDROGEN SENSOR - The invention relates to a capacitive sensing material and a method of manufacturing thereof, a capacitive sensing coating formulation, a capacitive chip, a capacitive sensor, a method for manufacturing a coated chip, a method for analysing the composition of a gaseous mixture, a use of particles comprising titanium oxide and platinum for sensing hydrogen, and a use of capacitive sensing material for detecting a gas leak. The capacitive sensing material comprises composite particles wherein porous titanium dioxide is at least in part coated with platinum particles. | 2022-02-10 |
20220042959 | OPTICAL DETECTION TYPE CHEMICAL SENSOR - An optical detection type chemical sensor includes a light source, a detection element and a photodetector. The detection element is constituted of a laminate in which a multilayer film including a chemical detection layer, an optical interference layer, and a half mirror layer is formed on a transparent substrate. At least one of the layers includes a magnetic material. Light from the light source is applied to the detection element under the condition that the light enters inside of the detection element from the rear surface of the transparent substrate on which the laminate is not formed and multiple reflection occurring in the laminate intensifies the magneto-optical effect. A subject is detected by using the photodetector to detect a magneto-optical signal indicating a change in reflected light from the laminate resulting from a change in an optical property resulting from a reaction in the chemical detection layer. | 2022-02-10 |
20220042960 | METHOD FOR DETERMINING PROPERTIES OF FOODS - A method utilizing a digital twin instance in relation to food to query current/future properties thereof. A digital twin instance representing the food is generated from a digital twin template. The digital twin instance has assigned thereto, for a first target variable describing a food property, a mathematical model with a model parameter and an environmental parameter. The digital twin instance has a probability distribution for the model parameter of the first target variable. In the course of the handling of the food until it reaches a shop and/or at the shop, a measurement of the parameter is made, the values thereof being stored and assigned to the twin instance. The mathematical model of the first target variable, the probability distribution of the model parameter and the values of the environmental parameter are used to ascertain a probability distribution with respect to the target variable. | 2022-02-10 |
20220042961 | DETERMINATION AND QUANTIFICATION OF PROTEOSE PEPTONE CONTENT AND/OR BETA-CASEIN CONTENT AND NUTRITIONAL COMPOSITION WITH REDUCED BETA-CASEIN DERIVED PROTEOSE PEPTONE CONTENT - The present invention relates to a method for determining and quantifying β-casein derived proteose peptones and/or β-casein, said method comprising the steps of (i) providing a dairy-based product to be analysed; (ii) subjecting said product using liquid chromatography-mass spectrometry analysis; (iii) determining and/or quantifying said β-casein derived proteose peptones and/or β-casein in said product by detecting compounds of defined m/z values or deconvoluting the mass spectrometry spectra to calculate monoisotopic masses. The present invention also relates to nutritional compositions having a reduced content of β-casein derived proteose peptones and the uses hereof for e.g. treating, preventing and/or ameliorating abdominal pain in an infant. | 2022-02-10 |
20220042962 | METHOD FOR VALIDATION OF SITE-SPECIFIC WATER QUALITY CRITERIA OF RIVER BASIN - A method for validation of site-specific water quality criteria of a river basin includes steps of: analyzing the biota distribution characteristics of a river basin; eliminating non-resident related species from the toxicity database of target pollutants; supplementing toxicity values of site-specific resident sensitive species and endemic species; establishing a resident toxicity database for the river basin; comparing the degrees of fitting of species sensitivity distribution (SSD) models and identifying the optimal SSD model; and validating the water quality criterion value to complete the derivation and validation of the site-specific water quality criteria of the river basin. The method can improve the nativeness of the site-specific water quality criteria of the river basin, be used for the formulation of the site-specific water environment quality standards of the river basin, and provide support for the water quality management of the river basin. | 2022-02-10 |
20220042963 | METHOD FOR IDENTIFYING AND ANALYZING DISSOLVED ORGANIC NITROGEN OF DIFFERENT SOURCES IN WASTEWATER AND APPLICATION OF THE METHOD - A method for identifying and analyzing dissolved organic nitrogen of different sources in wastewater includes extracting DON in wastewater to obtain a DON extract, detecting mass spectrum peaks in the DON extract, pre-processing the spectral data of the wastewater sample; constructing a network relationship of the substance reaction in the wastewater sample; screening the substance reaction relationship of DON; and determining different sources of DON. | 2022-02-10 |
20220042964 | WATER HARDNESS DETECTION PROBE, SENSOR, DETECTION METHOD AND WATER SOFTENER - A water hardness detection probe, sensor, detection method and water softener are provided. The sensor includes a control unit which includes a processing module and a potential detection module. The detection probe includes a first probe and a second probe. When the first and second probes are both exposed in raw water, a potential between the first and second probes is regarded as first potential. When the first probe is in the raw water and the second probe is in softened water, the potential between the first and second probes is regarded as the second potential. The potential detection module measures the potential between the first and second probes. The processing module determines the water hardness of the softened water according to a difference between the first potential and the second potential. The sensor can detect the water hardness of the water softener in real time and eliminate detection deviations. | 2022-02-10 |
20220042965 | BIOSENSOR, BIOSENSOR ARRAY AND DEVICE - A biosensor includes a stretchable substrate, a pixel defining layer on the stretchable substrate and including a first pixel defining layer at least partially defining a first opening and a second pixel defining layer at least partially defining a second opening, a photo-detecting element at least partially in the first opening, and a first light emitting element at least partially in the second opening, wherein an area of the first pixel defining layer is equal to or greater than about twice an area of the first opening. | 2022-02-10 |
20220042966 | NANOPORE DEVICE AND METHODS OF ELECTRICAL ARRAY ADDRESSING AND SENSING - A method of manufacturing and using a nanofluidic NAND transistor sensor array scheme including a plurality of nanopore channel pillars, a plurality of respective fluidic channels, a plurality of gate electrodes, a top chamber, and a bottom chamber includes placing a sensor substrate in an electrolyte solution comprising biomolecules and DNA. The method also includes placing first and second electrodes in the electrolyte solution (Vpp and Vss of the nanofluidic NAND transistor); forming the nanopore channel pillars; placing the gate electrodes and gate insulators in respective walls of the nanopore channel pillars; applying an electrophoretic bias in the first and second electrodes; applying a bias in the gate electrodes; detecting a change in an electrode current in the electrolyte solution caused by a change in a gate voltage; and detecting a change in a surface charge in nanopore channel electrodes in the respective fluidic channels. | 2022-02-10 |
20220042967 | METHOD OF ENCODING DATA ON A POLYNUCLEOTIDE STRAND - Provided herein are methods of encoding data on a polymer. Also provided are methods of reading data encoded on a polymer. Also provided are systems for encoding data on a polymer; systems for reading data encoded on a polymer; and data encoding/data reading platforms. | 2022-02-10 |
20220042968 | SYSTEMS AND METHODS FOR INSERTING A NANOPORE IN A MEMBRANE USING OSMOTIC IMBALANCE - Systems and methods for inserting a nanopore into a membrane covering a well are described herein. The membrane can be bowed outwards by establishing an osmotic gradient across the membrane in order to drive fluid into the well, which will increase the amount of fluid in the well and cause the membrane to bow outwards. Nanopore insertion can then be initiated on the bowed membrane. | 2022-02-10 |
20220042969 | MASS CONTROL SYSTEM FOR CHROMATOGRAPHY - The present invention relates to methods for controlling chromatographic processes in real-time via mass measurement utilizing a variable pathlength spectrophotometer. | 2022-02-10 |
20220042970 | CAPTURE, IDENTIFICATION AND USE OF A NEW BIOMARKER OF SOLID TUMORS IN BODY FLUIDS - A new sensitive cell biomarker of solid tumors is identified in blood. This biomarker can be used to determine presence of solid tumors, rapid determination of treatment response, early detection of cancer, early detection of cancer recurrence, and may be used to determine therapy. | 2022-02-10 |
20220042971 | METHODS FOR QUANTITATION OF INSULIN AND C-PEPTIDE - Methods are described for diagnosing or prognosing insulin resistance in diabetic and pre-diabetic patients, the method comprising determining the amount of insulin and C-peptide in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. | 2022-02-10 |
20220042972 | METHOD OF DETECTING PRESENCE OR ABSENCE OF A CLOT IN A LIQUID SAMPLE ANALYZER - The disclosure relates to a method of detecting a clot in a measurement chamber of a liquid sample analyzer, wherein the liquid sample analyzer comprises at least two analyte sensors, a first analyte sensor, for measuring a first analyte in a liquid sample, and one or more second analyte sensors, for measuring one or more second analytes in the liquid sample in the measurement chamber, the method comprising the steps of, (a) at least partly filling the measurement chamber with a known solution having a composition comprising the first analyte at a pre-determined level, and the second one or more analytes at pre-determined levels, (b) obtaining a first sequence of measurement results by the first analyte sensor, and simultaneously obtaining a second sequence of measurement results by the second, one or more analyte sensors, (c) determining a change of the first sequence of measurement results, (d) determining a change of the second or more sequence of measurement results, and (e) comparing the change of the first sequence of measurement results with the second sequence of measurement results. | 2022-02-10 |
20220042973 | AIRBORNE ORGANIC MATTER DETECTION SYSTEM AND METHOD - An aerosol detection system for detecting airborne organic matter, the detection system including a corridor extending along a longitudinal axis and having first and second ends; an access gate connected to the first end of the corridor and configured to control access of an individual to the corridor; a person detection system located in the corridor and configured to determine the presence of the individual inside the corridor; and a testing set configured to generate an air puff, which directs an exhaled breath of the individual for determining a presence of the airborne organic matter. The corridor has a width w | 2022-02-10 |
20220042974 | REPLACEABLE ALCOHOL SENSOR MODULE - A replaceable alcohol sensor module for use with a breathalyzer. The alcohol sensor module requiring calibration can be removed from the body of the breathalyzer and replaced with a new alcohol sensor module. The alcohol sensor module has at least an alcohol sensor and a circuitry mounted on a PCB that removable connects the replaceable alcohol sensor module to the breathalyzer. The circuitry transmits the signal and/or electrical current generated by the alcohol sensor to a processing unit of the breathalyzer for processing. | 2022-02-10 |
20220042975 | METHODS OF GENERATING ORGANOIDS FOR HIGH THROUGHPUT SCREENING OF DRUGS - Methods of generating organoids on multi-well plates are provided by depositing a polymeric solution comprising cells under conditions which result in a homogenous population of organoids, which can be used for high throughput analysis for drug screening and for determining treatment regimens of a drug. | 2022-02-10 |
20220042976 | MICROFLUIDIC PROXIMAL TUBULE KIDNEY-ON-CHIP - The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine. | 2022-02-10 |
20220042977 | Protein Solubility Screening Kits and Their Use - The present invention provides a multitude of biomacromolecule solubility screening kits, and methods of using such kits. Such kits provide a substantial improvement over presently available kits and methods and provide a substantial decrease in the amounts of biomacromolecules required to run such solubility screening. | 2022-02-10 |
20220042978 | HIGHLY SENSITIVE PARTICLE ENHANCED ASSAY FOR THE QUANTIFICATION OF NT-PROBNP - NT-proBNP can be determined in a biological sample using at least one antibody which recognizes an epitope of NT-proBNP in both a glycosylated and non-glycosylated form of NT-proBNP. Said antibody is preferably an isolated polyclonal antibody or a mixture of monoclonal antibodies coated onto a particle, preferably coated onto said particle in a coating ratio of 6-60%, forming a layer or multiple layers of antibodies on said particle. The assay, realized in the form of a nephelometric or turbidimetric assay, can be applied to a wide range of automated clinical analyzers. | 2022-02-10 |
20220042979 | BIOLOGICAL NANOPARTICLE DETECTING METHOD WITH HIGH SENSITIVITY - The present disclosure discloses a biological nanoparticle detection method with high-sensitivity in which the biological nanoparticle is reacted with a corresponding aptamer-modified copper compound nanoparticle for a period of time; then a surfactant is added to prevent the reactant particles from agglomeration; next, the reaction solution is passed through a filter membrane to enrich the biological nanoparticle-copper compound conjugate, during which small-sized molecules including proteins and uric acid pass directly through the filter membrane; then the filter membrane is washed with PBS, and silver nitrate is added for reaction; and finally a mixed solution of triethylamine hydrochloride, 3,3′,5,5′-tetramethylbenzidine and hydrogen peroxide are added for development, and the color change of the filter membrane is visually observed by naked eyes or by means of a camera. | 2022-02-10 |
20220042980 | Apparatus for Collecting and Detecting an Analyte in a Fluid Sample - The present invention provides an apparatus for detecting an analyte in a fluid sample, comprising a fluid sample collection element, comprising a fluid sample collection element that comprises an absorbing element; a carrier for accommodating a testing element; and a chamber for accommodating a testing element carrier, wherein the testing element carrier is located in the chamber, and the carrier further comprises an extrusion structure that is in contact with the absorbing element and extrudes the absorbing element. | 2022-02-10 |
20220042981 | BIOSENSOR MICROARRAY COMPOSITIONS AND METHODS - Described herein are biosensor microarrays comprising detector polypeptide monolayers substantially free of contaminants. Also provided are methods for generation of such biosensor microarrays by capture of polypeptides by arrays comprising capture moieties and associated sensors. | 2022-02-10 |
20220042982 | ADAPTATION OF NAPPA FOR SURFACE PLASMON RESONANCE IMAGING ANALYSES - Disclosed is a method that combines high throughput and flexible nature of a cell-free protein microarray with the quantitative capability of surface plasmon resonance to detect >400 different protein interactions in <1 hour. A method of detecting interactions between a targeting agent and one or more proteins of interest is disclosed. The method includes producing a set of proteins of interest using a cell-free protein expression system; providing the set of proteins of interest on a protein microarray wherein each spot in the array comprises a protein of interest; contacting the protein microarray with a targeting agent that binds to one or more of the set of proteins of interest; and detecting the binding of the targeting agent to the set of proteins of interest using surface plasmon resonance imaging (SPRi), thereby detecting the targeting agent and one or more proteins of interest in the micro array. | 2022-02-10 |
20220042983 | FLOW ASSAY ANALYZER - Described is a lateral flow high throughput assay device analyzer for preparing and analyzing a plurality of lateral flow assay samples. The analyzer comprises a cartridge stage for supporting an assay cartridge, an elevation adjustment mechanism, and a translation adjustment mechanism for aligning the cartridge stage and assay cartridge relative to a vertical support structure, fluid metering device, and detection device for high throughput lateral flow assay analysis. | 2022-02-10 |
20220042984 | Lateral Flow Assay Device for Detection of Analytes and Method of Detection Thereof - The present invention relates to a lateral flow assay device for detection of an analyte in a sample and a method of detection thereof. The present invention provides a quantitative assay for detection of an analyte in a sample. The present invention also provides a conjugate. The present invention provides a method of diagnosing COVID 19 in a patient. | 2022-02-10 |
20220042985 | SARS-CoV-2 IgG/IgM ANTI-BODY DETECTION KIT - Disclosed is a SARS-CoV-2 IgG/IgM detection kit. The kit includes a disposable test cassette and the disposable test cassette includes a base plate, a sample pad, a reaction pad and an absorbent pad. The sample pad, the reaction pad and the absorbent pad are sequentially connected and are provided on the base plate. The sample pad is coated with a colloidal gold-labeled recombinant SARS-CoV-2 S-RBD protein. The reaction pad is provided with a test line and a quality control line. The test line is coated with a mouse anti-human IgG and a mouse anti-human IgM and the quality control line is coated with a goat anti-mouse IgG. The kit provided herein can be used for rapid test of SARS-CoV-2 IgG/IgM, and has high accuracy, good stability and strong anti-interference performance. | 2022-02-10 |
20220042986 | ELEVATED TEMPERATURE WASH FOR ELECTROPHORESIS - An immunofixation electrophoresis method including separation of proteins (antigens) by electrophoresis, subjecting the separated proteins to various antisera to cause an antibody-antigen reaction and visualizing the results of the antibody-antigen reaction by staining, including a series of blotting and rehydrating steps with an elevated temperature rehydrating solution to remove unbound proteins (antigens), unreacted antisera, and excess stain. | 2022-02-10 |
20220042987 | SEVERE ACUTE RESPIRATORY SYNDROME (SARS) - ASSOCIATED CORONAVIRUS DIAGNOSTICS - The invention relates to the diagnosis of a SARS-associated coronavirus, such as a SARS CoV-2 infection and SARS-CoV infection, using the SARS-CoV and SARS-CoV-2 nucleocapsid proteins and antibodies binding to these proteins. The invention encompasses reagents, methods and kits for the detection of a SARS-associated coronavirus. | 2022-02-10 |
20220042988 | RAPID DIAGNOSIS OF PERITONITIS IN PERITONEAL DIALYSIS PATIENTS - Described is an assay for diagnosing an infection such as peritonitis in a subject. The assay includes a binding molecule, such as an antibody that specifically binds to an inflammatory marker in a sample from the subject, and a second binding molecule that binds to a marker indicative of a pathogen in the sample. For diagnosing peritonitis in a subject, the pathogen will be at least one bacterium and/or fungus. Typically, the assay will be incorporated into a lateral flow device and may include a binding molecule that specifically binds to an antigen indicative of the presence of a specific pathogen species. The described assay(s) may further include filter(s), enriching antigen(s), and buffer(s). Also described are methods of diagnosing and treating peritonitis in a subject who is a peritoneal dialysis patient that include utilizing the herein described assay(s) or assay kit(s) to analyze the subject's peritoneal dialysis effluent. | 2022-02-10 |
20220042989 | TRIAGE BIOMARKERS AND USES THEREFOR - Disclosed are methods, apparatus, kits and compositions for determining the absence of a systemic bacterial infection (sepsis) in patients, particularly ones presenting to hospital emergency departments (ED) as outpatients, by measurement of the host immune response using peripheral blood. The are methods, apparatus, kits and compositions can be used in mammals for diagnosing, making treatment decisions, determining the next procedure or diagnostic test, or management of patients suspected of having an infection, including those presenting with fever or other signs of systemic inflammation. More particularly, peripheral blood RNA and protein biomarkers are disclosed that are useful for distinguishing between the host immune response to bacteria compared to the host immune response to other causes of systemic inflammation including trauma, burns, autoimmune disease, asthma, anaphylaxis, arthritis, obesity and viral infections. As such, the biomarkers are useful for distinguishing bacterial-associated systemic inflammatory response syndrome from non-bacterial systemic inflammation to provide clinicians with strong negative predictive value (>95%) so that sepsis can be excluded as a diagnosis in patients presenting to ED with clinical signs of systemic inflammation. | 2022-02-10 |
20220042990 | METHOD FOR DETECTING CAUSATIVE BACTERIUM OF MASTITIS - An object of the present invention is to elucidate the cause of degradation of the reliability of detecting causative bacteria of environmental mastitis such as | 2022-02-10 |
20220042991 | Viral Assay Method - This invention relates to the rapid determination of the viral titer by contacting a solution comprising viral particles, such as lentiviral particles, comprising a heterologous envelope protein, such as VSV-G, with an immobilised receptor that binds to the envelope protein, and determining the binding of the viral particles to be immobilised receptor using surface plasmon resonance (SPR). | 2022-02-10 |
20220042992 | COMPOSITIONS AND METHODS FOR DETECTION AND TREATMENT OF CORONAVIRUS INFECTION - The present disclosure includes a multiplexed peptide assay to generate an epitope-resolved view of antibody reactivity across all human coronaviruses (CoVs). PepSeq accurately classifies SARS-CoV-2 exposure status and reveals epitopes across the Spike and Nucleocapsid proteins. Two of these represent recurrent reactivities to conserved, functionally-important sites in the S2 subunit of Spike, regions that we show are also targeted for the endemic CoVs in pre-pandemic controls. At one of these sites, we demonstrate that the SARS-CoV-2 response strongly and recurrently cross-reacts with the endemic virus hCoV-OC43. The disclosed epitope-resolved analysis reveals new CoV targets for the development of diagnostics, vaccines and therapeutics, including a site that may have broad neutralizing potential. | 2022-02-10 |
20220042993 | BETARETROVIRUS EPITOPES AND RELATED METHODS OF USE - Methods for determination of risk, previous history and/or presence of a betaretrovirus infection in a subject are described herein. Said methods may comprise incubating a biological sample from the subject, the biological sample comprising immune effector-producing cells, with one or more betaretrovirus-specific epitopes, the betaretrovirus-specific epitopes comprising at least 7 contiguous amino acids according to any one of SEQ ID Nos. 1-36, and measuring the production of immune effectors by the immune effector-producing cells, wherein production of the immune effectors by the immune effector-producing cells determines risk and/or presence of betaretrovirus infection in the subject. Isolated peptides and kits for carrying out the methods are also described. | 2022-02-10 |
20220042994 | SIGNATURES AND DETERMINANTS FOR DIAGNOSING INFECTIONS AND METHODS OF USE THEREOF - A kit is disclosed for distinguishing between bacterial and viral infections. One of the antibodies of the kit specifically binds to TNF-related apoptosis-inducing ligand (TRAIL) protein and another of the antibodies of the kit specifically binds to Procalcitonin (PCT) protein. | 2022-02-10 |
20220042995 | ENZYME QUANTIFICATION - The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number. | 2022-02-10 |
20220042996 | COMPOSITIONS AND METHODS RELATED TO LATROPHILINS AS BIOMARKERS FOR HAEMATOPOIETIC CELL CANCER - Disclosed is the use of latrophilin expression as a biomarker for the diagnosis of haematopoietic cell cancer in a subject, together with methods for diagnosis and a kit for the detection of latrophilin expression on white blood cells collected from a subject. | 2022-02-10 |
20220042997 | METHOD FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF PROSTATE CANCER METASTASIS - The present invention relates to a method for the diagnosis or the prognosis of metastasis in prostate cancer which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for the diagnosis or the prognosis of metastasis in prostate cancer, as well as to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which, comprise determining the c-MAF expression level. Finally, the invention relates to the use of a c-MAF inhibitor as therapeutic target for treating the prostate cancer. | 2022-02-10 |
20220042998 | BIOMARKERS FOR PANCREATIC CANCER - The present invention relates to pancreatic cancers and the use of biomarkers in biological samples for the diagnosis of such conditions, in particular pancreatic ductal adenocarcinoma. The biomarker panel comprises LYVE1, REG1 and TFF1. Methods of treatment are also provided, as well as kits useful in the diagnosis and treatment of pancreatic ductal adenocarcinoma. The present invention is particularly useful in detecting early-stage PDAC. | 2022-02-10 |
20220042999 | Quantitative Centrosomal Amplification Score to Predict Local Recurrence of Ductal Carcinoma In Situ - Embodiments may provide capability to predict the 10-year risk of local recurrence of ductal carcinoma in situ (DCIS) conditions or other non-invasive carcinomas in situ. Embodiments may evaluate the severity and frequency of numerical and structural CA present within DCIS, and may assign a quantitative centrosomal amplification score (CAS) to each sample. For example, a method of determining the risk profile of a carcinoma in situ in a patient may comprise determining severity and frequency of numerical and structural centrosome amplification present within a sample of a carcinoma in situ from the patient and determining at least one centrosome amplification score (CAS) value for the sample based on the determined severity and frequency of numerical and structural centrosome amplification in the sample, wherein the determined at least one CAS value provides a measure of a level of a 10-year risk of local recurrence associated with the carcinoma in situ. | 2022-02-10 |
20220043000 | METHODS AND KITS FOR DETECTING SARS-COV-2 PROTEIN IN A SAMPLE - Disclosed herein are methods, kits, and systems relates for detecting the presence or determining the amount of SARS-CoV-2 nucleocapsid protein in one or more samples obtained from a subject. | 2022-02-10 |
20220043001 | METHODS AND COMPOSITIONS FOR DETECTING MISFOLDED PROTEINS - Various aspects and embodiments of the present disclosure are directed to methods and compositions (e.g., kits) for the identification of subjects with misfolded proteins in their urine. For example, methods and compositions for determining that a urine sample from a pregnant woman contains or does not contain misfolded are provided. In some embodiments, the presence of misfolded proteins in a urine sample from a pregnant woman is an indication of preeclampsia. | 2022-02-10 |
20220043002 | Method and System of Identifying and Quantifying A Protein - Methods and system for identifying and/or quantifying a protein are provided herein. | 2022-02-10 |
20220043003 | ASSAYS FOR DETECTING SARS-COV-2 - The present disclosure relates to methods of detecting a protein from the SARS-CoV-2 virus, or a fragment thereof, in a sample obtained from a subject using a first antibody or antigen-binding fragment thereof that binds to a protein from the SARS-CoV-2 virus, or a fragment thereof, and a second antibody or antigen-binding fragment thereof which binds to a protein from the SARS-CoV-2 virus, or a fragment thereof. | 2022-02-10 |
20220043004 | USES OF IL-40 AND METHODS FOR DETECTING IL-40 ACTIVITY - The technology relates in part to methods for detecting the activity of IL-40 and modified versions thereof. The technology also relates in part to uses of IL-40 for promoting cell differentiation. | 2022-02-10 |
20220043005 | SELENOPROTEIN P IN HEART FAILURE - A method for assessing risk in a subject having heart failure that is (i) risk for getting a cardiovascular event and/or (ii) risk of worsening heart failure condition and/or (iii) assessing risk for mortality, and/or (iv) assessing risk of hospitalization or re-hospitalization due to heart failure, involves:
| 2022-02-10 |
20220043006 | METHOD FOR PREDICTING OR PROGNOSTICATING THE RESPONSE TO THE TREATMENT OF MULTIPLE SCLEROSIS WITH INTERFERON BETA - A method for predicting or prognosticating the response of individuals with multiple sclerosis to treatment with IFNβ, kit or device, and uses. | 2022-02-10 |
20220043007 | DIAGNOSING AND TREATING ALZHEIMERS DISEASE - Described herein are methods, systems and compositions for the diagnosis, prognosis and treatment of dementia and Alzheimer's disease. Also described are methods, systems and compositions to distinguish between Alzheimer's disease and Parkinson's disease. In various embodiments levels of PACAP and/or SIRT3 are analyzed for the diagnosis, prognosis and treatment of dementia and Alzheimer's disease. | 2022-02-10 |
20220043008 | HEMOGLOBIN ASSAY REAGENT, ASSAY KIT AND ASSAY METHOD - An object of the present invention is to provide a hemoglobin measurement reagent and measurement method that allow for more accurate measurement of the amount of hemoglobin by suppressing a decrease in a measured value of hemoglobin triggered by the addition of haptoglobin. The reagent for measuring hemoglobin of the present invention includes: an insoluble carrier immobilizing an anti-hemoglobin antibody; and an insoluble carrier immobilizing an anti-haptoglobin antibody. The method for measuring hemoglobin in a specimen of the present invention includes: a step (1) of mixing a specimen with haptoglobin and forming a hemoglobin-haptoglobin complex to obtain a sample containing the hemoglobin-haptoglobin complex; and a step (2) of bringing the sample obtained in the step (1) into contact with the insoluble carrier immobilizing an anti-hemoglobin antibody and the insoluble carrier immobilizing an anti-haptoglobin antibody to cause immunoagglutination. | 2022-02-10 |
20220043009 | CALIBRATORS AND CONTROLS FOR THE DETERMINATION OF PERCENT GLYCATED HEMOGLOBIN IN A PATIENT'S LIQUID TEST SAMPLE - Non-limiting embodiments of methodologies for preparing diagnostic assay(s) calibrator(s), calibration material(s), and/or control(s), as well as kits, devices, and method(s) of calibration related thereto. | 2022-02-10 |
20220043010 | DYE-BASED LIQUID REAGENT VOLUME INDICATOR FOR USE IN ANALYTE DETECTION ASSAYS - Non-limiting embodiments of a modified devices that comprise at least one dye for determining whether results obtained from the conductance of at least one diagnostic assay are biased, as well as kits and methods of use related thereto. | 2022-02-10 |
20220043011 | VITAMIN D METABOLITE DETERMINATION UTILIZING MASS SPECTROMETRY FOLLOWING DERIVATIZATION - The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry. | 2022-02-10 |
20220043012 | RELEASE REAGENT FOR VITAMIN D COMPOUNDS - A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein and an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin D compounds as well as a kit for detecting a vitamin D compound. | 2022-02-10 |
20220043013 | Multi-Parameter Metabolic Vulnerability Index Evaluations - Disclosed are methods and systems to determine a subject's metabolic vulnerability index (MVX) score using at least one defined mathematical model of risk. The methods comprise evaluating various biomarkers to distinguish various health risks. In one embodiment, the method comprises evaluating biomarkers to determine a relative risk of premature all-cause mortality. The model may include NMR-derived measurements of GlycA, S-HDLP, branched chain amino acids (BCAAs), ketone bodies, total serum protein, and citrate in at least one biosample of the subject. | 2022-02-10 |
20220043014 | MOLECULARLY-IMPRINTED-POLYMER COATED CONDUCTIVE NANOPARTICLES FOR COTININE DETECTION, AND ASSOCIATED DEVICES AND METHODS - A device for detecting cotinine includes (a) a film that includes a plurality of molecularly-imprinted-polymer (MIP) coated conductive nanoparticles having specific affinity for binding with cotinine, and (b) two electrodes in contact with the film for passing electrical current through the film to detect binding with cotinine as a change in electrical conductivity of the film. A MIP coated conductive nanoparticle for detecting cotinine includes (a) a conductive nanoparticle, (b) a silicon dioxide coating formed on the conductive nanoparticle and forming a first shell around the conductive nanoparticle, and (c) an MIP coating formed on the silicon dioxide coating and forming the second shell, wherein the MIP coating includes a polymer molecularly imprinted with cotinine to provide specific affinity for binding of cotinine to the MW coated conductive nanoparticle such that the cotinine is detectable as a change in electrical conductivity of the MW coated conductive nanoparticle. | 2022-02-10 |
20220043015 | Sample Supply System and Methods of Supplying Samples - Disclosed are high-throughput vessel supply systems and methods of supplying sample vessels, such as samples stored in test tubes. A system for supplying a plurality of individual vessels that each contains a sample is disclosed. | 2022-02-10 |