06th week of 2016 patent applcation highlights part 26 |
Patent application number | Title | Published |
20160040209 | FAST QUANTIFICATION OF ENZYME ACTIVITY BY ELECTROANALYSIS - The internally calibrated electrochemical continuous enzyme assay (ICECEA) was developed for the fast determination of enzyme activity unit. The assay uses integration of enzyme-free pre-assay calibration with the actual enzyme assay in one continuous experiment. Such integration results in a uniquely shaped amperometric trace that allows for the selective and sensitive determination of enzymes. | 2016-02-11 |
20160040210 | METHOD AND APPARATUS FOR IDENTIFICATION OF BACTERIA - An automated system for identifying in a biological sample microorganisms and their antimicrobial susceptibility (AST). The system provided an automated platform for preparing, from a single biological sample, inoculates for both ID and AST. The system loads a plate for ID testing as samples are being prepared for AST testing. The system tracks the sample and the inoculates from the samples to link the test results to the sample and the patients from whom the sample was obtained. | 2016-02-11 |
20160040211 | CULTURE MEDIUM METHOD AND DEVICE - Culture medium devices and systems are shown and described. In one embodiment, the device comprises a culture medium adapted for test fluid inoculation without the concerns associated with a spreading step. In particular examples, a printed grid on the outer surface of a culture device is visible on the inner surface for colony counting after a test has been developed. The result is a device that allows for detection, identification, and transportation of various microorganisms without preparation or spreading steps, and more particularly to a culture medium in which a test fluid inoculated thereto diffuses rapidly. | 2016-02-11 |
20160040212 | Methods for the Detection of DNA-RNA Proximity in Vivo - Disclosed is a method for detecting spatial proximity relationships between RNA and DNA molecules in a cell. The method includes: providing a sample of RNA and DNA wherein the RNA and fDNA have ends capable of joining to other DNA and RNA, respectively; joining at least one end of the fragmented RNA to the end of at least one fragmented DNA, to create at least one joined RNA-DNA hybrid molecule, wherein the join encodes the information about the proximity of the RNA and DNA in the cell; reverse transcribing the at least one joined rRNA-DNA hybrid molecule to create least one target join DNA molecule that retains the information of the join, and determining the sequence of the target join thereby detecting spatial proximity relationships between RNA and DNA molecules in a cell. | 2016-02-11 |
20160040213 | SYSTEMS AND METHODS FOR DETECTING THE PRESENCE OF A SELECTED VOLUME OF MATERIAL IN A SAMPLE PROCESSING DEVICE - Systems and methods for processing sample processing devices. The system can include a sample processing device comprising a detection chamber, a motor configured to rotate the sample processing device about an axis of rotation, and an optical module operatively positioned relative to the sample processing device and configured to determine whether a selected volume of material is present in the detection chamber of the sample processing device. The method can include rotating the sample processing device about an axis of rotation, and determining whether a selected volume of material is present in the detection chamber, while rotating the sample processing device. In some embodiments, determining whether a selected volume of material is present can be performed by optically interrogating the detection chamber for an optical property of the material. | 2016-02-11 |
20160040214 | Nucleic Acid Quantitation Method - The present method relates to methods of quantifying nucleic acids, and in particular to the use of a universal reference nucleic acid to generate a calibration curve from which the level of a target nucleic acid in a sample can be calculated. | 2016-02-11 |
20160040215 | Methods for Pathogen Detection and Enrichment from Materials and Compositions - Provided are methods and compositions for characterization of bacterial compositions for the maintenance or restoration of a healthy microbiota in the gastrointestinal tract of a mammalian subject, and the resulting characterized compositions. Provided are methods of characterizing bacterial compositions including subjecting the compositions to various detecting processes. | 2016-02-11 |
20160040216 | SYSTEMS AND METHODS TO ASSES MICROBIOMES AND TREATMENTS THEREOF - Systems and methods to assess the health of various microbiomes and to identity species therein are disclosed. Described assessments and identifications can inform treatment decisions if a microbiome is determined to have a less than optimal balance of bacterial species within it; the presence of one or more negative species; and/or the absence of one or more positive species. | 2016-02-11 |
20160040217 | METHODS AND KITS TO DETECT AND GENOTYPE CRYPTOCOCCUS SPECIES - Embodiments of the invention provide a method of genotyping a | 2016-02-11 |
20160040218 | Selective Purification of RNA and RNA-Bound Molecular Complexes - Disclosed are methods for isolating a target nucleic molecule of interest from a sample. The methods include contacting a sample comprising a target nucleic molecule of interest with at least one single stranded nucleic acid targeting probe comprising a nucleic acid sequence between about 30 nucleotide and the length of the target nucleic acid length that hybridizes to the target nucleic molecule of interest under highly stringent hybridization conditions. The probe comprises a capture moiety covalently linked to one or more nucleotide bases in the probe. The targeting probes can be captured with a specific binding agent that specifically binds the capture moiety, thereby isolating the target nucleic molecule of interest. In some embodiments, the sample is further contacted with a crosslinking agent before contacting the sample with a targeting probe. Thus, complexes formed with the target nucleic acid can also be isolated. | 2016-02-11 |
20160040219 | PROBES FOR IMPROVED MELT DISCRIMINATION AND MULTIPLEXING IN NUCLEIC ACID ASSAYS - Methods and compositions for the detection and quantification of nucleic acids are provided. In certain embodiments, methods involve the use of cleavable probes that comprise a ribonucleotide position that is susceptible to endoribonuclease (e.g., RNase H) cleavage in the presence of target nucleic acid molecules. Probes of the embodiments may also comprise non-natural nucleotide linked to a reporter and/or quenching moiety. | 2016-02-11 |
20160040220 | METHODS FOR THE DETECTION OF BREAKPOINTS IN REARRANGED GENOMIC SEQUENCES - Methods for detecting the amplifications of sequences in the BRCA1 locus, which sequences have ends consisting of or are framed with sequence stretches present at least twice in the BRCA1 locus, and which amplification results in at least two or at least three, especially three, tandem copies of the amplified sequence; methods for determining a predisposition to diseases or disorders associated with these amplifications, including predisposition to ovarian cancer or breast cancer and methods for detecting amplifications with similar features in other loci and/or for predicting breakpoints of such amplifications. | 2016-02-11 |
20160040221 | IDENTIFICATION OF BIOLOGICALLY AND CLINICALLY ESSENTIAL GENES AND GENE PAIRS, AND METHODS EMPLOYING THE IDENTIFIED GENES AND GENE PAIRS - A method of obtaining cut-off expression values should be selected so as to maximise the separation of the respective survival curves of the two groups of patients. Pairs of genes are statistically significant genes are generated by generating a plurality of models, each of which represents a way of partitioning a set of subjects based on the optimal cut-off expression values of the pair of genes. Those gene pairs are identified for which one of the models has a high prognostic significance. Novel survival significant gene sets forming functional modules which could be used to develop specific prognostic and predictive tests are derived. | 2016-02-11 |
20160040222 | Systems And Methods For Baseline Correction Using Non-Linear Normalization - Systems and methods are provided for calibrating emission data or other information signals collected during a polymerase chain reaction (PCR), amplification reaction, assay, process, or other reaction. Calibration of multiple detectable materials can be achieved during a single cycle or run, or during a plurality of runs of the reaction. A reading from every well, container, or other support region of a sample support does not have to be taken. Interpolation can be used to determine values for emission data or other information signals that were not taken, or are unknown, using detected emission data, or other detected information signals. By calibrating the detected emission data and the interpolated data, a more accurate reading of emission data or information signal can be obtained. | 2016-02-11 |
20160040223 | SINGLE NUCLEOTIDE DETECTION METHOD - A method for determining the sequence of nucleotide bases in a polynucleotide analyte is provided. It is characterised by the steps of (1) generating a stream of single nucleotide bases from the analyte; (2) producing captured molecules by reacting each single nucleotide base with a capture system; (3) amplifying at least part of the captured molecule to produce a plurality of amplicons characteristic of the single nucleotide base; (4) labelling the amplicons with a corresponding probe having a characteristic detectable element and (5) detecting a property characteristic of the detectable element. | 2016-02-11 |
20160040224 | SINGLE NUCLEOTIDE DETECTION METHOD - A method for determining the sequence of nucleotide bases in a polynucleotide analyte is provided. It is characterised by the steps of (1) generating a stream of single nucleotide bases from the analyte by pyrophosphorolysis; (2) producing captured molecules by reacting each single nucleotide base with a capture system labelled with detectable elements in an undetectable state; (3) releasing the detectable elements from each captured molecule in a detectable state and (4) detecting the detectable elements so released and determining the sequence of nucleotide bases therefrom. The method can be used advantageously in sequencers involving the use of microdroplets. | 2016-02-11 |
20160040225 | MODIFIED NUCLEOTIDE LINKERS - Some embodiments of the present application relate to novel modified nucleotide linkers for increasing the efficiency of nucleotide incorporation in Sequencing by Synthesis applications. Methods of preparing these modified nucleotide linkers are also provided herewith. | 2016-02-11 |
20160040226 | MANIPULATION OF MICROPARTICLES IN MICROFLUIDIC SYSTEMS - An array of transportable particle sets is used in a microfluidic device for performing chemical reactions in the microfluidic device. The microfluidic device comprises a main channel and intersecting side channels, the main channel and side channels forming a plurality of intersections. The array of particle sets is disposed in the main channel, and the side channels are coupled to reagents. As the particle sets are transported through the intersections of the main channel and the side channels, reagents are flowed through the side channels into contact with each array member (or selected array members), thereby providing a plurality of chemical reactions in the microfluidic system. | 2016-02-11 |
20160040227 | PARALLEL POLYMER SEQUENCING METHODS - The present invention relates to a method of sequencing a target polynucleotide by enzymatic and/or chemical means. The sequencing method includes a method for characterizing multiple alleles in a sample, a method of calculating confidence levels in ascertained sequences, a method for comparing polynucleotide sequences and a method of resolving ambiguities in a polynucleotide sequence. It also provides methods for appropriately preparing samples, for immobilising template molecules, for organising the template molecules and to conduct the sequencing of many molecules in parallel. The method involves analysing molecules as members of an array. Many target polynucleotides or many segments of a single target polynucleotide can be sequenced simultaneously. In a preferred embodiment the method involves analysing individual molecules within an array and base calls are based on the signals from two or more molecules. A method to prevent non-specific signal in sequencing is also provided. The invention is readily automated, both for small-scale and large-scale operation and relevant algorithms and the composition of kits and systems are provided. | 2016-02-11 |
20160040228 | SEQUENCING STRATEGIES FOR GENOMIC REGIONS OF INTEREST - The disclosure relates to methods for determining the sequence of a genomic region of interest comprising a target nucleotide sequence comprising: providing a DNA comprising a genomic region of interest, fragmenting the DNA, separating the DNA fragments, fragmenting and ligating the DNA fragments to provide for ligated fragments of the DNA fragments (or ligated DNA subfragments), and determining at least part of the sequences of at least part of the ligated DNA subfragments that comprise the target nucleotide sequence. | 2016-02-11 |
20160040229 | SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION - The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease. | 2016-02-11 |
20160040230 | Compositions, Devices, Systems, and Methods for Using a Nanopore - Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof. | 2016-02-11 |
20160040231 | SINGLE MOLECULE NUCLEIC ACID SEQUENCE ANALYSIS PROCESSES AND COMPOSITIONS - Improved solid supports and methods for analyzing target nucleotide sequences are provided herein. Certain improvements are directed to efficiently preparing nucleic acids that comprise nucleotide sequences identical to or substantially identical to one or more target nucleotide sequences, or complement thereof. The prepared nucleic acids include a reference sequence that facilitates sequence analysis. The solid supports and methods provided herein minimize the number of steps required by published sequence analysis methodologies, and thereby offer improved sequence analysis efficiency. | 2016-02-11 |
20160040232 | METHODS AND COMPOSITIONS FOR DETECTING NON-HEMATOPOIETIC CELLS FROM A BLOOD SAMPLE - The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a non-hematopoietic tumor cell, in a blood sample via, inter alia, removing red blood cells (RBCs) from a blood sample using a non-centrifugation procedure, removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; and assessing the presence, absence and/or amount of said enriched non-hematopoietic cell. | 2016-02-11 |
20160040233 | ADVANCED DETECTION OF SEPSIS - The present invention relates to methods, monitors and systems, useful, for example, for advanced detection of sepsis in a subject. | 2016-02-11 |
20160040234 | METHODS OF SEQUENCING THE IMMUNE REPERTOIRE - The invention provides a non-invasive technique for the detection and quantification of the immune repertoire, in a biological sample containing a plurality of distinct cell populations. Methods are conducted using sequencing technology to detect and enumerate immune repertoire within a heterogeneous biological sample. | 2016-02-11 |
20160040235 | Methods for Diagnosing and Treating Diseases Caused by Genetic Copy Number Variants of Ultra-Conserved Elements - Methods for inducing cell apoptosis by cellular comparison of genetic copy number variants of ultra-conserved elements. | 2016-02-11 |
20160040236 | SYSTEMS AND METHODS FOR CHARACTERIZATION OF MULTIPLE SCLEROSIS - Methods and systems to characterize multiple sclerosis in a subject, e.g., in a subject a progressive form of MS are disclosed. | 2016-02-11 |
20160040237 | KIR3DL1 ALLELE CLASSIFICATION KIT AND METHOD - Disclosed herein are single nucleotide polymorphisms (SNPs) characteristic of functional subgroups of KIR3DL1. Also disclosed herein are methods for classifying KIR3DL1 alleles by using a series of oligonucleotide primers and PCR reaction conditions uniquely designed to identify group-specific SNPs from genomic DNA. The compositions and methods disclosed herein are useful in clinical settings and research laboratories, and enable prospective assessment of prognoses of various diseases and selection of most appropriate donors for HCT. | 2016-02-11 |
20160040239 | METHODS FOR PREDICTING CARDIOVASCULAR RISKS AND RESPONSIVENESS TO STATIN THERAPY USING SNPS - Methods and compositions for the effect of Cholesteryl ester transfer protein (CETP) polymorphisms on mRNA splicing, statin treatment outcome, response to CETP inhibitor drugs, and myocardial infarction risk are described. | 2016-02-11 |
20160040240 | CACNA1C ALLELE AND TREATMENT OF MOOD DISORDERS - Provided herein are methods of determining a treatment regimen for a subject with a mood disorder and methods of identifying a patient with a mood disorder as amenable to treatment with a calcium channel blocker (CCB). In exemplary embodiments, the methods comprise (a) analyzing a sample obtained from a subject with a mood disorder for the presence of allele [A] of CACNA1C, wherein allele [A] comprises the sequence of the polymorphic marker rs1006737. | 2016-02-11 |
20160040241 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING CORONARY HEART DISEASE - The invention pertains to a method of determining a statin dosage for an individual in need of treatment with a statin, comprising determining a SLCO1B1 genotype from a nucleic acid sample of the individual, said genotype comprising the presence or absence of the SLCO1B1-056 polymorphism, and determining an ApoE genotype or phenotype identifying an ApoE polymorphism selected from the group consisting of ApoE2, ApoE3, ApoE4, and any combination thereof, wherein the combination of a SLCO1B1 genotype identifying the presence of the SLCO1B1-056 C polymorphism and the ApoE genotype or phenotype identifying one of the ApoE3/4 or ApoE4/4 genotypes indicates the statin dosage. | 2016-02-11 |
20160040242 | Methods and Kits for Detecting Nucleic Acid Mutants in Wild-Type Populations - This disclosure relates to amplification and detection of a rare variant or variants of a DNA sequence in an abundant variant of the sequence, such as detection of a low-level somatic mutations and minority alleles in an excess of normal nucleic acid target sequences. | 2016-02-11 |
20160040243 | METHODS AND NUCLEOTIDE FRAGMENTS OF PREDICTING OCCURRENCE, METASTASIS OF CANCERS AND PATIENTS' POSTOPERATIVE SURVIVAL IN VITRO - Provided in the present invention are a method using in vitro measurement of the content of methylation or demethylation of GFRal CpG islands to estimate a risk of tumorigenesis and of tumor metastasis, or postoperative life expectancy, and a nucleotide sequence used. | 2016-02-11 |
20160040244 | METHOD FOR DETECTING GASTRIC POLYP AND GASTRIC CANCER MARKER GENE OF GASTRIC POLYP AND GASTRIC CANCER-SPECIFIC METHYLATION - The present invention relates to the novel use of syndecan-2 (SDC2; NM_002998) gene as a gastric polyp- and gastric cancer-specific methylation biomarker, and more particularly, to the use of the syndecan-2 gene as a biomarker that enables gastric polyp and gastric cancer to be diagnosed in an early stage by measuring the methylation level thereof. The present invention has an effect in that the methylation of the CpG island of the gastric polyp- and gastric cancer-specific marker gene can be detected to thereby provide information for diagnosing gastric cancer. The use of the methylation detection method according to the present invention or the diagnostic composition, kit or nucleic acid chip according to the present invention makes it possible to diagnose gastric cancer at an early transformation stage, thus enabling the early diagnosis of gastric cancer. In addition, the method of the present invention enables gastric cancer to be effectively diagnosed in an accurate and rapid manner compared to conventional methods. | 2016-02-11 |
20160040245 | CIRCULATING TUMOR CELL DIAGNOSTICS FOR DETECTION OF NEUROENDOCRINE PROSTATE CANCER (NEPC) - The present invention describes a method for detecting NEPC in a patient afflicted with prostate cancer comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characterization of nucleated cells in a blood sample obtained from the patient to detect circulating tumor cells (CTC), and (b) determining presence or absence of a CTC subpopulation associated with NEPC comprising detecting a measurable feature of each biomarker in a panel of morphological and protein biomarkers, wherein the presence of the CTC subpopulation associated with NEPC is indicative of NEPC. In other embodiments, the biomarkers for the CTC subpopulation associated with NEPC comprise small size, absence of Androgen Receptor (AR | 2016-02-11 |
20160040246 | DETECTING NEOPLASM - Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer. Accordingly, provided herein is technology for pancreatic cancer screening markers and other gastrointestinal cancer screening markers that provide a high signalto-noise ratio and a low background level when detected from samples taken from a subject (e.g., stool sample). As described herein, the technology provides a number of methylated DNA markers and subsets thereof (e.g., sets of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or more markers) with high discrimination for G1 neoplasms overall and/or at individual tumor sites. | 2016-02-11 |
20160040247 | METHOD FOR THE DIAGNOSIS, PROGNOSIS, AND TRATMENT OF CANCER METASTASIS - This study describes a method to determine the likelihood of the development of metastasis in a subject suffering from cancer, in addition to a method to design a customized therapy in a subject suffering from cancer, in particular breast, colon, lung, kidney and thyroid cancer, based on the determination of the expression level of one or more genes whose expression is modulated by an increase in c-MAF expression. It also describes a method for the identification of marker genes with a propensity for metastatic cancer based on inducing the modulation of the c-MAF expression Finally, the use of PTHLH and PODXL inhibitors and RERG activators in the treatment and/or prevention of the cancer, in particular breast, colon, lung, kidney and thyroid cancer. | 2016-02-11 |
20160040248 | METHOD TO IMPROVE EXPRESSION AND OTHER BIOLOGICAL ANALYSIS - A method to verify single data points by substituting multiple data points that predict the original value measured is described. This is applied to determining gene expression levels. | 2016-02-11 |
20160040249 | METHODS FOR THE DETECTION OF SEQUENCE AMPLIFICATION IN THE BRCA1 LOCUS - Methods for detecting the amplifications of sequences in the BRCA1 locus, which sequences have ends consisting of or are framed with sequence stretches present at least twice in the BRCA1 locus, and which amplification results in at least two or at least three, especially three, tandem copies of the amplified sequence; methods for determining a predisposition to diseases or disorders associated with these amplifications, including predisposition to ovarian cancer or breast cancer and methods for detecting amplifications with similar features in other loci. | 2016-02-11 |
20160040250 | TERT PROMOTER MUTATIONS IN CANCER - The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions related to certain promoter mutations in cancer. In one embodiment, a method for treating a subject having thyroid cancer comprises the steps of (a) obtaining a biological sample from the subject; (b) performing an assay on the sample obtained from the subject to identify a mutation at 1 295 228 C>T (C228T) and 1 295 250 C>T (C250T), corresponding to −124 C>T and −146 C>T from the translation start site in the promoter of the telomerase reverse transcriptase (TERT) gene; (c) identifying the subject as having or likely to develop aggressive thyroid cancer if the C228T and/or C250T mutation is identified; and (d) treating the subject with one or more treatment modalities appropriate for a subject having or likely to develop aggressive thyroid cancer. | 2016-02-11 |
20160040251 | BIOMARKERS FOR THE IDENTIFICATION OF CHEMOSENSITIVITY - The instant application provides biomarkers for the identification of chemosensitivity in patient having cancer, in a particular embodiment the invention provides MST for the identification of chemosensitivity in breast cancer patient, wherein a reduced expression of XIST in the breast cancer cells of the patient indicates that the breast cancer stem cells in the patient may be successfully treated with HDAC inhibitor. | 2016-02-11 |
20160040252 | METHODS AND COMPOSITIONS FOR TREATING CANCER - The invention is directed to methods, reagents, and kits for the detection of MAPK/ERK pathway mutations in a patient diagnosed for cancer. In one embodiment, the invention comprises a sensitive and selective method to identify mutations to the BRAF, KRAS, and NRAS genes in a single reaction. In another aspect of this embodiment, the invention comprises primers and C probes for the detection of the BRAF, KRAS, and NRAS mutations using a single nucleotide primer extension assay. In another embodiment the invention is used to identify and select patients amenable for treatment with an ERK inhibitor. | 2016-02-11 |
20160040253 | METHOD FOR MANUFACTURING GASTRIC CANCER PROGNOSIS PREDICTION MODEL - The present invention relates to a novel model for predicting a prognosis capable of predicting the prognosis of gastric cancer, and more specifically, to manufacturing a prediction model for predicting a clinical result after a resection during gastric cancer surgery through genetic mutation comparative analysis. | 2016-02-11 |
20160040254 | PROGNOSTIC AND DIAGNOSTIC METHODS BASED ON QUANTIFICATION OF SOMATIC MICROSATELLITE VARIABILITY - Prognostic and diagnostic methods based on somatic microsatellite variability measurements are described. Somatic microsatellite variability measurements can be used to identify defects in DNA repair pathways in a biological sample and to predict or identify one or more pathologies. The methods may statistically compare somatic microsatellite variability between a sample from a cell line or subject with that of a reference sample with defined pathological characteristics and/or defined lesions in DNA repair pathways. The methods are useful for determining the probability that an individual may develop a pathology, such as a cancer, within a specific time frame, and/or are useful as a diagnostic test. The methods have clinical utility in that somatic variability can be evaluated and/or measured as an indication of the amount of genomic instability (e.g., microsatellite and non-microsatellite/SNP), which can then be used as a clinical diagnostic to make clinical decisions, especially in the area of cancer. | 2016-02-11 |
20160040255 | Polynucleotide Primers For Detecting PIK3CA Mutations - A polynucleotide comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 3 to 16, 18, 20 to 33, 35 or 37 to 39. A method of detecting the presence or absence of a mutation in the PIK3CA gene, wherein the mutation is one of H1047R, H1047L, E542K and E545K, and preferably ARMS primers are combined with Scorpion primers. | 2016-02-11 |
20160040256 | METHODS, COMPOSITIONS, AND KITS FOR DETECTING ALLELIC VARIANTS - In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating sequence variation between different alleles. More specifically, in some embodiments, the present invention provides for compositions, methods and kits for quantitating rare (e.g., mutant) allelic variants, such as SNPs, or nucleotide (NT) insertions or deletions, in samples comprising abundant (e.g., wild type) allelic variants with high specificity and selectivity. In particular, in some embodiments, the invention relates to a highly selective method for mutation detection referred to as competitive allele-specific TaqMan PCR (“cast-PCR”). | 2016-02-11 |
20160040257 | NOVEL FUNGAL STRAIN BEAUVERIA SP. MTCC 5184 AND A PROCESS FOR THE PREPARATION OF ENZYMES THEREFROM - A fungal strain | 2016-02-11 |
20160040258 | Lactose Recovery - The present invention relates to a method of recovering lactose from a lactose-containing liquid source comprising providing a lactose-containing liquid source, crystallising the lactose in the lactose-containing liquid source to generate one or more lactose-containing liquid streams, recovering a lactose-containing extract from the one or more lactose-containing liquid streams by subjecting the one or more lactose-containing liquid streams to filtration to remove cells, proteins, polypeptides, polysaccharides, lipid, ions or salts. The method also includes processing the lactose-containing liquid streams using at least nanofiltration, ultrafiltration and/or centrifugal separation and recycling the lactose-containing extract into the lactose-containing liquid source. | 2016-02-11 |
20160040259 | METHOD FOR MIXED BIOMASS HYDROLYSIS - Methods and systems are disclosed for the hydrolysis of mixed biomass. The methods include forming a mixture of at least two modified biomass feedstocks to achieve various benefits, such as maximizing sugar yields and minimizing the formation of degradation products. | 2016-02-11 |
20160040260 | METHOD FOR TREATING A SUBSTRATE MADE OF ANIMAL FIBERS WITH SOLID PARTICLES AND A CHEMICAL FORMULATION - The invention discloses a method for treating an animal substrate comprising: agitating the moistened animal substrate with a treatment formulation and a solid particulate material in a sealed apparatus wherein the treatment formulation comprises a tanning agent or a tannery process agent. The method can comprise applying the tanning agent or tannery process agent to the animal substrate wherein at least some of the agent so applied originates from the treatment formulation. There is also disclosed an animal substrate obtained by the method. The treatment formulation can be aqueous. | 2016-02-11 |
20160040261 | BLAST FURNACE OPERATION METHOD AND LANCE - A method is provided for operating a blast furnace by blowing a solid reducing material, a flammable gaseous reducing material and a combustible gas into a blast furnace from tuyeres through a lance into a blast furnace, wherein a parallel type lance prepared by bundling three independent blowing tubes in parallel and integrally housing them into an outer tube is used, and either one or both of the gaseous reducing material and the combustible gas and the solid reducing material are simultaneously blown through the respective blowing tubes, while the blowing tube for the solid reducing material and the blowing tube for the gaseous reducing material are positioned above the blowing tube for the combustible gas in the blowing through the parallel type lance as well as a lance structure thereof. | 2016-02-11 |
20160040262 | SURFACE HARDENABLE STAINLESS STEELS - Alloys, a process for preparing the alloys, and manufactured articles including the alloys are described herein. The alloys include, by weight, about 11.5% to about 14.5% chromium, about 0.01% to about 3.0% nickel, about 0.1% to about 1.0% copper, about 0.1% to about 0.2% carbon, about 0.01% to about 0.1% niobium, 0% to about 5% cobalt, 0% to about 3.0% molybdenum, and 0% to about 0.5% titanium, the balance essentially iron and incidental elements and impurities | 2016-02-11 |
20160040263 | RAIL MANUFACTURING METHOD AND MANUFACTURING EQUIPMENT - Rail manufacturing method performs, on at least a head of the rail that is hot after hot-rolled at an austenite region temperature or higher or after heated to the austenite region temperature or higher, forced cooling: for 10 seconds from start of the forced cooling so that a cooling rate at a surface of the head becomes 1° C./s to 20° C./s; during a period after a lapse of 10 seconds from the start until heat generation during transformation begins at the surface so that the cooling rate becomes 1° C./s to 5° C./s; during transformation from beginning to end of the heat generation during transformation so that the cooling rate becomes lower than 1° C./s or a temperature-rising rate becomes 5° C./s or lower; and during a period after the end of the heat generation during transformation until temperature at the surface becomes 450° C. or lower so that the cooling rate becomes 1° C./s to 20° C./s. | 2016-02-11 |
20160040264 | STEEL FOR BLADES AND METHOD FOR PRODUCING THE SAME - An object of the present invention is to provide steel for blades with a significantly improved carbide concentration and a method for producing the same. The steel for blades has a metal composition consisting of, by mass, 0.55% to 0.8% C, not more than 1.0% Si, not more than 1.0% Mn, 12.0% to 14.0% Cr, and the balance of Fe with inevitable impurities, wherein the number of carbides in a ferrite structure of the steel for blades is 600 to 1,000 per an area of 100 μm | 2016-02-11 |
20160040265 | ROTARY DEGASSER AND ROTOR THEREFOR - A device for dispersing gas into molten metal includes an impeller, a drive shaft having a gas-transfer passage therein, and a first end and a second end, and a drive source. The second end of the drive shaft is connected to the impeller and the first end is connected to the drive source. The impeller includes a first portion and a second portion with a plurality of cavities. The first portion covers the second portion to help prevent gas from escaping to the surface without entering the cavities and being mixed with molten metal as the impeller rotates. When gas is transferred through the gas-transfer passage, it exits through the gas-release opening(s) in the bottom of the impeller. At least some of the gas enters the cavities where it is mixed with the molten metal being displaced by the impeller. Also disclosed are impellers that can be used to practice the invention. | 2016-02-11 |
20160040266 | PLATINUM GROUP METAL REFINING - A process for refining platinum group metals (PGM) first removes concentrations of base metals (BM) from the PGM through precipitation of the BM by increasing alkalinity in the dissolving aqueous solution. A large fraction of the aqueous solution is distilled before increasing alkalinity. Os is recovered from the distillate The aqueous solution is heated following precipitation of the BM; and the PGM is loaded on borane containing reduction resins. The loaded resins are washed; and the PGM is stripped from the resins with gaseous oxygen. The stripped PGM are then processed using only substituted quaternary ammonium salt (SQAS) as the refining reagent. The waste solutions from the refining are all combined together; solvent is removed; residual PGM is recycled in the process; and concentrated SQAS is recovered for further refining. Pt, Pd and Ru are refined from acidic SQAS solutions by reducing the metals from the solutions with H | 2016-02-11 |
20160040267 | PRODUCTION OF COPPER-67 FROM AN ENRICHED ZINC-68 TARGET - An apparatus including a heating element and a sublimation vessel disposed adjacent the heating element such that the heating element heats a portion thereof. A collection vessel is removably disposed within the sublimation vessel and is open on an end thereof. A crucible is configured to sealingly position a solid mixture against the collection vessel. | 2016-02-11 |
20160040268 | A method for extracting rare-earth metals - The present invention relates to a method for complex processing of apatite concentrate resulting in producing concentrate of rare earth metals (REM) and plaster from phosphogypsum, a waste of sulphuric acid technology for producing phosphoric acid from apatite. The method comprises recrystallization of hemihydrate or anhydrite of calcium sulphate into dihydrate of calcium sulphate in the presence of a soluble calcium salt at concentrations of 0.075-3.75 M (in terms of Ca | 2016-02-11 |
20160040269 | REFILL FOR A BALL-POINT PEN AND USE THEREOF - The invention relates to a refill for a ball-point pen, comprising an ink cartridge and a ball, said ball being arranged in a writing tip provided at the front end of the ink cartridge, wherein at least the writing tip of the ink cartridge consists of a copper-zinc alloy of the following composition (wt. %): 28.0 to 36.0% Zn, 0.5 to 1.5% Si, 1.5 to 2.5% Mn, 0.2 to 1.0% Ni, 0.5 to 1.5% Al, 0.1 to 1.0% Fe, optionally also up to a maximum of 0.1% Pb, optionally also up to a maximum of 0.2% Sn, optionally also up to a maximum of 0.1% P, optionally also up to a maximum of 0.08% S, the rest being Cu and inevitable impurities, with mixed silicides containing iron, nickel and manganese being embedded in the matrix. | 2016-02-11 |
20160040270 | ELECTRIC AND ELECTRONIC PART COPPER ALLOY SHEET WITH EXCELLENT BENDING WORKABILITY AND STRESS RELAXATION RESISTANCE - An electric and electronic part copper alloy sheet with excellent bending workability and stress relaxation resistance is made from a copper alloy containing 1.5 to 4.0 percent by mass of Ni, Si satisfying a Ni/Si mass ratio of 4.0 to 5.0, 0.01 to 1.3 percent by mass of Sn, and the remainder composed of copper and incidental impurities, wherein the average crystal grain size is 5 to 20 μm, the standard deviation of the crystal grain size satisfies 2σ<10 μm, and the proportion of the number of particles having a particle diameter of 90 to 300 nm in Ni—Si dispersed particles having a particle diameter of 30 to 300 nm is 20% or more, where the particles are observed in a cross-section defined by a direction perpendicular to a sheet surface and a direction parallel to a rolling direction. | 2016-02-11 |
20160040271 | Silver-Bismuth Powder,Conductive Paste and Conductive Film - To provide a silver-bismuth powder, which includes: silver; and bismuth, wherein a mass ratio (silver:bismuth) of the silver to the bismuth is 95:5 to 40:60, wherein a cumulative 50% point of particle diameter (D50) of the silver-bismuth powder in a volume-based particle size distribution thereof as measured by a laser diffraction particle size distribution analysis is 0.1 μm to 10 μm, and wherein an oxygen content of the silver-bismuth powder is 5.5% by mass or less. | 2016-02-11 |
20160040272 | DIE-CASTABLE NICKEL BASED SUPERALLOY COMPOSITION - A die-cast nickel based superalloy includes 4.5-5.5 wt % Tungsten (W), 1.5-2.5 wt % Columbium (Cb), 4.5-5.5 wt % Tantalum (Ta), 0.5-5.0 wt % Titanium (Ti), and 0.5-3.0 wt % Aluminum (Al), | 2016-02-11 |
20160040273 | HIGH-STRENGTH LOW-SPECIFIC-GRAVITY STEEL SHEET HAVING SUPERIOR SPOT WELDABILITY - A steel sheet including, by mass %, C: more than 0.100% and 0.500% or less, Si: 0.0001% or more and less than 0.20%, Mn: more than 0.20% and 0.50% or less, Al: 3.0% or more and 10.0% or less, N: 0.0030% or more and 0.0100% or less, Ti: more than 0.100% and 1.000% or less, P: 0.00001% or more and 0.0200% or less, S: 0.00001% or more and 0.0100% or less, and a remainder including Fe and impurities, in which a sum of a C content and a Ti content satisfies 0.2002016-02-11 | |
20160040274 | THICK STEEL SHEET HAVING EXCELLENT CTOD PROPERTIES IN MULTILAYER WELDED JOINTS, AND MANUFACTURING METHOD FOR THICK STEEL SHEET - Provided are a thick steel plate with which a welded joint having good CTOD property is formed by low-to-medium heat input multipass welding and a method for producing the thick steel plate. | 2016-02-11 |
20160040275 | High Strength Thin Steel Sheet for the Superior Press Formability and Surface Quality and Galvanized Steel Sheet and Method for Manufacturing the Same - A high strength thin steel sheet that is mainly used for structural members and inner and outer panels for a vehicle, a galvanized steel sheet, and methods of manufacturing the same. The high strength thin steel sheet for superior press formability includes, by weight percent, 0.06 to 0.4% C, 1.0 to 5.0% Mn, 0.05 to 2.5% Si, 0.01 to 2.0% Ni, 0.02 to 2% Cu, 0.01 to 0.04% Ti, 0.05 to 2.5% Al, 0.005 to 0.1% Sb, 0.0005 to 0.004% B, 0.007% or less N, and balance Fe and inevitable impurities, and meeting relation of Ni+0.5×Mn+0.3×Cu>0.9, which is defined as Ni*, and Al/Ni*<1.3 at a same time, and relation of Ti≧0.028×Al. This thin steel sheet is galvanized or galvannealed. | 2016-02-11 |
20160040276 | HEAT-RESISTANT Ni-BASED ALLOY AND METHOD FOR MANUFACTURING SAME - The present invention is a heat-resistant Ni-base alloy including a Ni—Ir—Al—W alloy having essential additive elements of Ir, Al, and W added to Ni, wherein the heat-resistant Ni-base alloy includes Ir: 5.0 to 50.0 mass %, Al: 1.0 to 8.0 mass %, and W: 5.0 to 20.0 mass %, the balance being Ni, and a γ′ phase having an L1 | 2016-02-11 |
20160040277 | NI-BASED SUPERALLOY WITH EXCELLENT UNSUSCEPTIBILITY TO SEGREGATION - A subject for the invention is to diminish the occurrence of streak-type segregation in producing a material comprising a Ni-based superalloy. The invention relates to a Ni-based superalloy having excellent unsusceptibility to segregation, characterized by comprising: 0.005 to 0.15 mass % of C; 8 to 22 mass % of Cr; 5 to 30 mass % of Co; equal or greater than 1 and less than 9 mass % of Mo; 5 to 21 mass % of W; 0.1 to 2.0 mass % of Al; 0.3 to 2.5 mass % of Ti; up to 0.015 mass % of B; and up to 0.01 mass % of Mg, with the remainder comprising Ni and unavoidable impurities. | 2016-02-11 |
20160040278 | SLURRY FOR THERMAL SPRAYING, THERMAL SPRAYED COATING, AND METHOD FOR FORMING THERMAL SPRAYED COATING - A thermal spray slurry of the present invention contains ceramic particles having an average particle size of 200 nm or more and 5 μm or less. Precipitates formed when 700 mL of the thermal spray slurry is placed in a 16.5-cm-high cylindrical vessel having a volume of 1 L and is allowed to stand still at room temperature for 1 week are made to disappear by disposing, at a temperature of 20° C. or higher and 30° C. or lower, the cylindrical vessel so as for the central axis of the cylindrical vessel to be horizontal and by rotating the cylindrical vessel at a rotation speed of 100 rpm for 120 minutes around the central axis of the cylindrical vessel to stir the thermal spray slurry in the cylindrical vessel. | 2016-02-11 |
20160040279 | SURFACE-COATED BORON NITRIDE SINTERED BODY TOOL - In a surface-coated boron nitride sintered body tool, at least a cutting edge portion contains a cubic boron nitride sintered body and a coating layer formed on a surface of the cubic boron nitride sintered body. A layer B of the coating layer is formed by alternately laminating one or more layers of each of two or more thin-film layers having different compositions. A B1 thin-film layer as one of the thin-film layers is formed by alternately laminating one or more layers of each of two or more compound layers having different compositions. Each of the compound layers has a thickness not less than 0.5 nm and less than 30 nm. A B2 thin-film layer as one of the thin-film layers different from the B1 thin-film layer has a thickness more than 30 nm and less than 200 nm. | 2016-02-11 |
20160040280 | Wear Resistant Vapor Deposited Coating, Method of Coating Deposition and Applications Therefor - A low friction top coat over a multilayer metal/ceramic bondcoat provides a conductive substrate, such as a rotary tool, with wear resistance and corrosion resistance. The top coat further provides low friction and anti-stickiness as well as high compressive stress. The high compressive stress provided by the top coat protects against degradation of the tool due to abrasion and torsional and cyclic fatigue. Substrate temperature is strictly controlled during the coating process to preserve the bulk properties of the substrate and the coating. The described coating process is particularly useful when applied to shape memory alloys. | 2016-02-11 |
20160040281 | Spallation-Resistant Thermal Barrier Coating - A coated article has: a metallic substrate ( | 2016-02-11 |
20160040282 | GETTER STRUCTURE AND METHOD FOR FORMING SUCH STRUCTURE - A getter structure and method wherein a layer of seed material is deposited on a predetermined region of a surface of a structure under conditions to form a plurality of nucleation sites on a surface of the structure. The nucleation sites have an average height over the surface area of the predetermined region of less than one molecule thick. Subsequently a getter material is deposited over the surface to form a plurality of getter material members projecting outwardly from the nucleation sites. | 2016-02-11 |
20160040283 | SURFACE-COATED CUTTING TOOL - A surface-coated cutting tool of the present invention includes: a hard coating layer which is vapor-deposited on a surface of a tool body made of tungsten carbide-based cemented carbide and has an average thickness of 2 mm to 10 mm, in which (a) the hard coating layer comprises a layer made of complex nitride of Al, Cr, and B in which a ratio (atomic ratio) of the amount of Cr is 0.2 to 0.45 and a ratio (atomic ratio) of the amount of B is 0.01 to 0.1 to the total amount of Al, Cr, and B, and (b) in an area within 100 mm from an edge tip on a flank face of the surface-coated cutting tool, the hard coating layer has a granular crystal grain structure and the average grain size of granular crystal grains is 0.1 mm to 0.4 mm on the surface of the hard coating layer. | 2016-02-11 |
20160040284 | PRESSURE MODULATED COATING - A method or control strategy in a coating apparatus for use in a coating process can include controlling differential gas pressures among multiple selected localized zones in a coating chamber with respect to each other. The controlled differential gas pressure of the multiple selected localized zones is used to influence how a coating deposits on at least one component. The localized zones can be selected from a first localized zone around the component, a second localized zone adjacent the source of coating material, a third localized zone that diverges from the second localized zone toward the first localized zone, and a fourth localized zone that circumscribes at least the third localized zone | 2016-02-11 |
20160040285 | SURFACE COATED CUTTING TOOL - A hard coating layer on a cutting tool includes at least a Ti and Al complex nitride or carbonitride layer and has an average layer thickness of 1 to 20 μm. In a case where a composition of the complex nitride or carbonitride layer is expressed by: (Ti | 2016-02-11 |
20160040286 | PARTICLE IMPROVEMENT FOR SINGLE WAFER APPARATUS - An apparatus includes a susceptor, a first piping, a second piping, a liquid source, a third piping and a gas source. The susceptor is suitable for placing a wafer, and the first piping is configured to dispense a chemical to the wafer on the susceptor. The second piping communicates with the first piping. The liquid source is configured to deliver a cleaning liquid to the first piping through the second piping to wash a portion of the first piping. The third piping communicates with the first piping. The gas source is configured to flow a purge gas to the first piping through the third piping to purge the portion of the first piping. | 2016-02-11 |
20160040287 | Tungsten Film Forming Method - A tungsten film forming method includes forming a tungsten film on a surface of a substrate to be processed by sequentially supplying a WCl | 2016-02-11 |
20160040288 | APPARATUS FOR IN SITU DEPOSITION OF MULTILAYER STRUCTURES VIA ATOMIC LAYER DEPOSITION AND ULTRA-HIGH VACUUM PHYSICAL OR CHEMICAL VAPOR DEPOSITION - An apparatus for in situ fabrication of multilayer heterostructures is provided comprising a first vacuum chamber adapted for atomic layer deposition and comprising a first stage docking assembly configured to dock a detachable stage configured to support a substrate; a second vacuum chamber adapted for ultra-high vacuum physical or chemical vapor deposition and comprising a second stage docking assembly configured to dock the detachable stage; a load lock vacuum chamber between the first and second vacuum chambers and comprising a third stage docking assembly configured to dock the detachable stage, the load lock vacuum chamber coupled to the first vacuum chamber via a first shared valve and coupled to the second vacuum chamber via a second shared valve; and a substrate transport vacuum chamber comprising a substrate transfer device, the substrate transfer device configured to detachably couple to the detachable stage and to transfer the substrate supported by the detachable stage in situ between the first vacuum chamber, the second vacuum chamber and the load lock vacuum chamber. | 2016-02-11 |
20160040289 | BIS(ALKYLIMIDO)-BIS(ALKYLAMIDO)MOLYBDENUM MOLECULES FOR DEPOSITION OF MOLYBDENUM-CONTAINING FILMS - Bis(alkylimido)-bis(alkylamido)molybdenum compounds, their synthesis, and their use for the deposition of molybdenum-containing films are disclosed. | 2016-02-11 |
20160040290 | ROLL-TO-ROLL ELECTROLESS PLATING SYSTEM FOR CONTROLLED SUBSTRATE DEPTH - A roll-to-roll electroless plating system for controlled substrate depth includes electroless plating solution disposed within an electroless plating bath, a conveyor system configured to convey a roll-to-roll substrate material through the electroless plating solution, a first depth setting roller disposed at an entry location of the roll-to-roll substrate material to the electroless plating solution, and a second depth setting roller disposed at an exit location of the roll-to-roll substrate material from the electroless plating solution. A diameter of the first and the second depth setting rollers is selected to dispose the roll-to-roll substrate material at a predetermined depth of the electroless plating solution. | 2016-02-11 |
20160040291 | ROLL-TO-ROLL ELECTROLESS PLATING SYSTEM WITH MICRO-BUBBLE INJECTOR - A roll-to-roll electroless plating system including a reservoir containing plating solution. A web advance system advances a web of media though the plating solution in the reservoir, wherein a plating substance in the plating solution is plated onto predetermined locations on a surface of the web of media. A distribution system injects an inert gas into the plating solution to reduce the amount of dissolved oxygen. The distribution system includes an injector having a converging tube segment, a diverging tube segment downstream of the converging tube segment, a throat formed at a junction of the converging tube segment and the diverging tube segment, and an inlet for the inert gas in proximity to the throat. | 2016-02-11 |
20160040292 | ROLL-TO-ROLL ELECTROLESS PLATING SYSTEM WITH LOW DISSOLVED OXYGEN CONTENT - A roll-to-roll electroless plating system including a sump containing a first volume of a plating solution, and a pan containing a second volume of the plating solution, the second volume being less than the first volume. A web advance system advances a web of media though the plating solution in the pan, wherein a plating substance in the plating solution is plated onto predetermined locations on a surface of the web of media. A pan-replenishing pump moves plating solution from the sump to the pan through a pipe. A distribution system injects an inert gas into the plating solution to reduce the amount of dissolved oxygen. | 2016-02-11 |
20160040293 | METHOD FOR ROLL-TO-ROLL ELECTROLESS PLATING WITH LOW DISSOLVED OXYGEN CONTENT - A method of electrolessly plating a web of media, including advancing the web of media from an input roll through a pan of plating solution to a take-up roll, wherein a plating substance in the plating solution is plated onto predetermined locations on a surface of the web of media. The plating solution is circulated from a sump to the pan and back to the sump through enclosed pipes, such that plating solution in the enclosed pipes is not exposed to air. An amount of dissolved oxygen in the plating solution is measured, and an inert gas is injected into the plating solution at a rate that is controlled according to the measured amount of dissolved oxygen. | 2016-02-11 |
20160040294 | METHOD OF CONTROLLING OXYGEN LEVELS FOR ELECTROLESS PLATING OF CATALYTIC FINE LINES OR FEATURES - A method of controlling oxygen levels for electroless plating of catalytic fine lines or features includes selecting a substrate that includes a plurality of catalytic lines or features that are part of or are disposed on the substrate. The plurality of catalytic lines or features include at least one catalytic fine line or feature and at least one catalytic standard line or feature. A dissolved oxygen concentration of an electroless plating solution is regulated to a candidate controlled oxygen level. The candidate controlled oxygen level is set to a smallest value in a regulated range in a first pass of the method. The substrate is submerged in the solution for a period of time sufficient to initiate plating of the at least one catalytic standard line or feature. The substrate is evaluated and candidate controlled oxygen level is incremented or the previous value is selected as the regulated oxygen level. | 2016-02-11 |
20160040295 | METHOD FOR ACTIVATING A COPPER SURFACE FOR ELECTROLESS PLATING - The present invention relates to method for activating a copper or copper alloy surface for depositing a metal or metal alloy layer by electroless (autocatalytic) plating thereon wherein the formation of undesired voids is suppressed. The copper or copper alloy surface is contacted with palladium ions, at least one phosphonate compound and halide ions followed by electroless (autocatalytic) deposition of a metal such as palladium or a metal alloy such as a Ni—P alloy. | 2016-02-11 |
20160040296 | ELECTROLESS GOLD PLATING LIQUID - The present invention relates to an electroless gold plating liquid, which may form gold plating without corrosion of a base metal by performing substitution and reduction reactions in the same bath, and satisfy both weldability of lead-free soldering and wire bonding characteristics, and has excellent stability such that a gold deposition rate may be continuously maintained. | 2016-02-11 |
20160040297 | Chemical Conversion Coated Plated Steel Sheet and Method for Producing Same - The present disclosure relates to a chemically treated zinc-based plated steel sheet that is superior in weather resistance, water resistance, blackening resistance and film adhesion. A chemical conversion film having a thickness 0.5-10 μm is formed by coating and drying a chemical treatment solution on a surface of an aluminum-containing zinc-based alloy plated steel sheet. The chemical treatment solution contains a fluororesin containing 0.05-5% by weight of a hydrophilic functional group selected from the group consisting of a carboxyl group and a sulfonic acid group and 7-20% by weight of a fluorine atom, the fluororesin in which a number-average molecular weight is 1,000-2,000,000, and an oxoate, a fluoride, a hydroxide, an organic salt, a carbonate or a peroxygenated salt of a group 4A metal. | 2016-02-11 |
20160040298 | CHEMICAL CONVERSION AGENT AND METAL SURFACE TREATMENT METHOD - Provided is a chemical conversion agent that, with respect to an aluminum metal material, etc., contributes to superior corrosion and moisture resistance, contributes to superior adhesion with a laminate film, and contributes to superior hydrofluoric acid and alkali resistance. The chemical conversion agent includes: one or more type of metal element (A) selected from a group comprising of zirconium, titanium, and hafnium; vanadium element (B); and a resin (C). The resin (C) includes a polyvinyl alcohol resin (C1). The ratio (Wa/Wb) of the weight-based total content (Wa) of the metal element (A) relative to the weight-based content (Wb) of vanadium element (B) is 0.1-15, and the ratio ((Wa+Wb)/Wc1) of the weight-based total content (Wa+Wb) of the metal element (A) and the vanadium element (B) relative to the weight-based total content (Wc1) of the polyvinyl alcohol resin (C1) is 0.25-15. | 2016-02-11 |
20160040299 | METHOD FOR PREPARING A CARBIDE CERAMICS MULTILAYER COATING ON, AND OPTIONALLY IN, A PART MADE OF A CARBON-CONTAINING MATERIAL USING A REACTIVE MELT INFILTRATION RMI TECHNIQUE - A method preparing a metals carbides multilayer coating on at least one surface of a first carbon layer of a substrate, or under the surface inside the first carbon layer, by a reactive melt infiltration technique, includes: a) putting the surface into contact with a solid metal disilicide MSi | 2016-02-11 |
20160040300 | Azole Compounds as Corrosion Inhibitors - A composition for application to a metal substrate comprises a metal cation, an azole compound and an aqueous carrier. A composition for coating a substrate comprises a carrier comprising an epoxy carrier, a urethane carrier, or a fluorinated urethane carrier, and an azole compound. A coated substrate includes the composition for application to a metal substrate and a coating on the composition. A method of fabricating a coated substrate comprises applying the composition to a substrate, allowing the composition to dry to form a conversion coating, and applying a coating on the conversion coating. | 2016-02-11 |
20160040301 | Composition and Method for Treating White Rust - A composition and method of inhibiting white rust on galvanized steel in water system. The composition preferably comprises two parts, a first part comprising oleylamine and optionally comprising 2-diethylaminoethanol and cyclohexylamine, and a second part comprising phosphonobutane tricarboxylic acid, tolytrizole, and a polymer, and optionally comprising a tracer or sodium hydroxide. A preferred composition comprises two commercially available products, Cetamine V217 S and Chem-Aqua 31155. A preferred method of inhibiting white rust comprises adding the two parts of the composition or two commerically available products to the water in a water system to be treated in an amount sufficient to provide a concentration of the first part of around 200-500 ppm and of the second part of around 50-150 ppm. | 2016-02-11 |
20160040302 | ANODE FOR CATHODIC PROTECTION AND METHOD FOR MANUFACTURING THE SAME - It is described a metal anode for cathodic protection in form of mesh ribbon having meshes whose holes are of rhomboidal shape, characterised by having such holes of rhomboidal shape arranged with the major diagonal oriented along the direction of the ribbon length and by the fact that the side edges along the ribbon length are free from cutting protrusions. It is also described a method for obtaining such anode. | 2016-02-11 |
20160040303 | Techniques for Photocatalytic Hydrogen Generation - Techniques for photocatalytic hydrogen generation are provided. In one aspect, a hydrogen producing cell is provided. The hydrogen producing cell includes an anode electrode; a photocatalytic material adjacent to the anode electrode; a solid electrolyte adjacent to a side of the photocatalytic material opposite the anode electrode; and a cathode electrode adjacent to a side of the solid electrolyte opposite the photocatalytic material. A solar hydrogen producing system including at least one solar concentrating assembly having the hydrogen producing cell, and a method for producing hydrogen using the hydrogen producing cell are also provided. | 2016-02-11 |
20160040304 | ELECTROCHEMICAL HYDROXIDE SYSTEMS AND METHODS USING METAL OXIDATION - There are provided methods and systems for an electrochemical cell including an anode and a cathode where the anode is contacted with a metal ion that converts the metal ion from a lower oxidation state to a higher oxidation state. The metal ion in the higher oxidation state is reacted with hydrogen gas, an unsaturated hydrocarbon, and/or a saturated hydrocarbon to form products. | 2016-02-11 |
20160040305 | APPARATUS AND METHOD FOR THE PRODUCTION OF AN ACID SUPER OXIDATION SOLUTION AND AN ALKALINE SOLUTION WITH INDEPENDENT FLOWS WITH ORP FROM AQUEOUS SOLUTIONS - This invention includes an electrolysis chamber and method for producing controlled flow acid electrolyzed water and controlled flow alkaline electrolyzed water with independent flows from aqueous solutions. Its objective is to produce controlled flow acid water with an oxide reduction potential (ORP) between +1100 and +1200 mV and a pH between 1.5 and 2.9 with a stability and shelf life of over a year, and controlled flow alkaline electrolyzed water with a pH between 9.0-11.0 and an ORP between −700 mV to −800 mV with a shelf life of more than a year. | 2016-02-11 |
20160040306 | ELECTROCHEMICAL PROCESS AND SYSTEM FOR PRODUCING GLUCOSE - An electrochemical process and system for producing glucose and glucose precursors are described. The process and system allow for the production of glucose from carbon dioxide and water, requiring only melanin, or a precursor, derivative, analog, or variant of melanin, and electromagnetic energy, such as visible or invisible light energy. | 2016-02-11 |
20160040307 | HYDROGEN ENERGY SUPPLY SYSTEM USING OCEAN CURRENT POWER GENERATION - A hydrogen energy supply system including 10 or more water wheel impeller type power generation devices that are supported to float in water by first floating bodies and generate electric power by using ocean currents; a second floating body on which a seawater electrolysis device, a hydrogen liquefaction device, and a liquid hydrogen tank are arranged; a hydrogen transporting ship that accommodates the liquid hydrogen stored in the liquid hydrogen tank and transports it by sea to land; an overland liquid hydrogen tank that stores the liquid hydrogen supplied from the hydrogen transporting ship; a small cylinder that accommodates the liquid hydrogen supplied from the overland liquid hydrogen tank; and a hydrogen transporting vehicle that transports the small cylinder to a consumer on land. | 2016-02-11 |
20160040308 | ELECTROLYSIS CELL AND METHOD FOR OPERATING AN ELECTROLYSIS CELL - An electrolysis cell, having an anode, a cathode, and a membrane that is situated between the anode and the cathode and contacts the anode via an anode contact area and contacts the cathode via a cathode contact area, wherein the cathode contact area is greater than the anode contact area, the membrane has a surface oriented toward the cathode that is greater than the cathode contact area, and the electrolysis cell has cathodically polarized surfaces that are in direct contact with the electrically conductive water. This invention also relates to a method for operating an electrolysis cell in natural water and a use of such an electrolysis cell for disinfecting water are also proposed. | 2016-02-11 |
20160040309 | LIQUID ACTIVATION AND ELECTROLYTIC APPARATUS AND LIQUID ACTIVATION AND ELECTROLYTIC METHOD - A liquid activation and electrolytic apparatus includes: a liquid activation apparatus that includes a liquid activator with a black radiation sintered body radiating electromagnetic waves and an electromagnetic wave converging body and assembled bodies integrated together with the black radiation sintered body on the outside, the electromagnetic wave converging body on the inside, and a liquid activation region by the electromagnetic waves formed on the inside of the electromagnetic wave converging body and activates, in the above region, a liquid portion of a liquid electrolytic solution; and an electrolytic unit that includes an electrolysis container using a titanium or platinum electrode as a negative electrode and a platinum electrode as a positive electrode and containing the electrolytic solution and a power source applying a variable direct-current voltage to the negative and positive electrodes and performs the electrolysis of the electrolytic solution with the activated liquid portion in the electrolysis container. | 2016-02-11 |