08th week of 2012 patent applcation highlights part 34 |
Patent application number | Title | Published |
20120045732 | DENTAL PASTE DISPENSING DEVICE AND METHOD OF USE - A dental paste dispensing device having a modified dispensing end for atraumatic contact with soft tissue is disclosed. The dispensing device has a metal needle with an attachment end adapted to be attached to a capsule containing the dental paste and a dispensing end with a terminal edge for dispensing the dental paste to a location in a patient mouth containing soft tissue, wherein the dispensing end includes an atraumatic modification. The modification comprises one of a non-metal coating on an outer surface of the dispensing end, a plastic tip member over the dispensing end, or a decreasing diameter at the terminal edge from a first point on the outer surface to a distal-most point of the outer surface. | 2012-02-23 |
20120045733 | Dental Appliance - The dental appliance includes a pouch for an index finger with a dentifrice carrying pad. The pouch covers the index finger to at least a midsection region. The dentifrice pad is atop the user's finger pad surface. The pouch has an elongated tail which extends proximally to at least beyond the thumb of the user. The tail has one or many thumb holes, located at a proximal region, and the user, upon insertion of his or her finger in the pouch, pulls the tail and insert his or her thumb in the thumb hole. Therefore, the thumb hole is adapted to encircle the thumb of the user when the pouch is mounted on the user's index finger. The tail may be elastic. The dentifrice pad (with dry powder) sometimes includes bumps or ridges. Alternatively, the tail may be long to wrap around the wrist of the user. | 2012-02-23 |
20120045734 | Dental Wedge Device With Guiding Wire - A dental wedge device for pulling between teeth. The device features a wedge component having a first end and a second end, the first end being generally pointed; and a generally flexible guiding wire. The guiding wire traverses the wedge component and the first end of the guiding wire extends from the first end of the wedge component and the second end of the guiding wire extends from the second end of the wedge component. In some embodiments, one or more knots are disposed along a portion of the guiding wire that traverses the wedge component. | 2012-02-23 |
20120045735 | IMPLANT REPAIR SYSTEM AND METHOD - A dental implant system includes bone growth promoting material configured for disposal within a body cavity about an implant. A protective element is configured to overlay the bone growth promoting material. Methods of use are also disclosed. | 2012-02-23 |
20120045736 | ANCHORING IMPLANT - An implant includes a collar configured for disposal within tissue. The collar defines an axial bore. A shaft extends between a first end and a second end. The shaft is configured for disposal with the bore of the collar. A base defines an axial bore having an inner surface configured for engagement with the shaft such that the base is axially movable relative to the shaft. At least one arm extends between the collar and the base. The at least one arm is movable via axial movement of the base relative to the shaft between a first position and a second position such that the at least one arm is expanded in a configuration to engage tissue. Methods of use are also disclosed. | 2012-02-23 |
20120045737 | METAL/PLASTIC HOUSING - A metal/plastic housing useable for releasable denture attachment to an o-ring abutment of a dental implant, within which an elastomeric o-ring is seatable, wherein the elastomeric o-ring is an elastomeric orthodontic o-ring. | 2012-02-23 |
20120045738 | METHOD FOR ENHANCING VIABILITY OF PERIODONTAL TISSUE CELLS - In a method for enhancing viability of periodontal tissue cells associated with more than one tooth, the periodontal tissue cells are irradiated simultaneously by an LED (light emitting diode) module having a light emitting range covering the associated teeth, wherein the irradiating energy is between 0.1 J/cm | 2012-02-23 |
20120045739 | ORAL HYGIENE TOOL - An oral hygiene tool comprising a wand extending from an end to an attachment end, an absorbent swab connected to the wand at the attachment end; where the absorbent swab collects a layer of saliva within a mouth of a person, a textured bottom of the absorbent swab, a domed top connected to an opposite portion of the absorbent swab form the textured bottom, wherein the domed top and the textured bottom of the absorbent swab collect the layer of saliva while the wand moves the absorbent swab over a plurality of surfaces to clean within the mouth. | 2012-02-23 |
20120045740 | NON-INVASIVE DETERMINATION OF NEUROTRANSMITTER INDICATION AND APPLICATIONS USING SAME - An indication of a level of a neurotransmitter in an individual or for a group may be non-invasively determined. The neurotransmitter may be oxytocin. The determined indicator may be used to determine actions to increase effectiveness of an organization. | 2012-02-23 |
20120045741 | Peri-Mid - An architecture is presented that provides a behavior monitoring and communication system. The system comprises behavior monitoring, cueing and communication devices designed to efficiently teach children and others self-monitoring skills with minimum adult intervention. The behavior monitoring, cueing and communication devices comprise at least one detection device that detects predefined behavior, such as positive or disruptive behaviors, and at least one monitoring device that monitors the predefined behavior. The system is programmed and overseen by the instructor or teacher from any location in the room through the use of the monitoring device. Further, the monitoring device can control and monitor more than one detection device simultaneously. | 2012-02-23 |
20120045742 | HEMORRHAGE CONTROL SIMULATOR - A simulator trains for hemorrhage control using hemostatic agents, tourniquets, and/or other hemorrhage control techniques in a simulator that works with a wide variety of existing human surrogates. The simulator merges a live video feed of the surrogate and trainee's hands (or objects interacting with the surrogate) with a computer-generated visual representation of the wound and hemorrhaging blood to provide an immersive display experience to the trainee without requiring different surrogates for different simulated wounds. The trainee may wear pulse-generating glove(s) that simulate the patient's pulse where the trainee's finger tip contacts the surrogate. A sensorized substrate (e.g., load sensors, haptic output generators) may automatically be moved between the trainee and the surrogate to sense interaction with the surrogate and provide haptic feedback. The substrate may replace the surrogate altogether. The simulator may alternatively simulate events and objects other than wounds and humans. | 2012-02-23 |
20120045743 | ORGAN MODEL - A material for forming an organ model containing an aqueous gel, which comprises polyvinyl alcohol having an average degree of polymerization of 300 to 3500 and a degree of saponification of not less than 90% by mole, and silica particles; a method for producing a material for forming an organ model, comprising cooling an aqueous polyvinyl alcohol solution which contains polyvinyl alcohol having an average degree of polymerization of 300 to 3500 and a degree of saponification of not less than 90% by mole and silica particles, to a temperature of −10° C. or lower, and thawing the resulting formed aqueous gel; and an organ model at least provided with a surface layer comprising the material for forming an organ model. Thus, it is possible to provide: an organ model which has a hydrophilic property similar to an organ of a human body, gives such an incision feel that an incised portion spreads just similar to a living human organ and, therefore can be appropriately used in, for example, exercising surgical procedures; a material for forming an organ model appropriately usable for the organ model; and a method for producing the same. | 2012-02-23 |
20120045744 | Collaborative University Placement Exam - An exemplary proficiency examination system includes a collaborative system allowing multiple administrators across multiple educational institutions to add questions to a bank of questions from which an administrator at a single educational institution may select for a proficiency examination. The questions may be used in a placement examination for placing students into a class of an appropriate skill level. | 2012-02-23 |
20120045745 | REMOTE CLASS SERVICE SYSTEM - Disclosed is a remote class service system, which enables active learning and lecture through bidirectional communication between a student and a lecturer who are remote from each other. | 2012-02-23 |
20120045746 | ELECTRONIC CLASS SYSTEM - Disclosed is an electronic class system which enables a digitalized class, wherein breaking from a conventional class method or an examination method using paper teaching materials for class and a blackboard for writing class contents, the digitalized class uses an electronic pen which is a digitalized writing tool for generating writing data, a computer which communicates with the electronic pen to receive the writing data generated by the electronic pen, and a smart board which serves as a blackboard on which the writing data received by the computer is projected as beams. | 2012-02-23 |
20120045747 | KIT FOR DETECTING HEPATITIS B VIRUS AND METHOD FOR DETECTING HEPATITIS B VIRUS USING THE SAME - A kit for detecting HBV in a test sample is disclosed. In addition a method is described for the real-time detection of HBV in a test sample using the kit. According to method of detection, the results of the detection can be rapidly identified with a reduced number of copies of a sample in real-time. | 2012-02-23 |
20120045748 | Particulate labels - A methodology for bioassays and diagnostics in which a particulate label (ranging in size from nm-scale molecular assemblages to organisms on the scale of tens or hundreds of microns), such as, but not limited to, nanoparticles, bacteria, bacteriophage, Daphnia, and magnetic particles, serve carriers for analytes bound by molecular recognition elements such as antibodies, aptamers, etc. The described methodology is generally applicable to most pathogen assays and molecular diagnostics and also leads to enhanced sensitivity and convenience of use. | 2012-02-23 |
20120045749 | METHODS OF CATEGORIZING AN ORGANISM - The invention generally relates to methods of identifying and categorizing organisms and more specifically methods of generating and using patterns of chromosomal variation in order to classify organisms. | 2012-02-23 |
20120045750 | KIT FOR DETECTING HIV-2 AND METHOD FOR DETECTING HIV-2 USING THE SAME - A kit for detecting HIV-2 strains in a test sample is disclosed. In addition a method is described for the real-time detection of HIV-2 strains in a test sample using the kit. According to method of detection, the results of the detection can be rapidly identified with a reduced number of copies of a sample in real-time. | 2012-02-23 |
20120045751 | Generic Sample Preparation - The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner. | 2012-02-23 |
20120045752 | FIBER SAMPLER FOR RECOVERY OF BIOAEROSOLS AND PARTICLES - A bioparticle collection device and an aerosol collection system. The bioparticle collection device includes a collection medium including a plurality of fibers formed into a fiber mat and configured to collect bioparticles thereon, and includes a viability enhancing material provider disposed in a vicinity of the plurality of fibers and configured to provide a viability enhancing material to the collected bioparticles to maintain viability of the bioparticles collected by the fiber mat. The aerosol collection system includes an aerosol pumping device configured to entrain particles in an gas stream, an aerosol saturation device configured to saturate the particles in the gas stream with a biocompatible liquid, and an aerosol collection medium downstream from the aerosol saturation device and including a plurality of fibers formed into a fiber mat for collection of the saturated aerosol particles. | 2012-02-23 |
20120045753 | SEQUENCES DIAGNOSTIC FOR SHRIMP PATHOGENS - Primers have been isolated that are diagnostic for the detection of the white spot syndrome virus (WSSV). The primers are based on a new portion of the WSSV genome and may be used in primer directed amplification or nucleic acid hybridization assay methods. | 2012-02-23 |
20120045754 | NOVEL GOLD NANOSTRUCTURES AND METHODS OF USE - The invention is drawn to novel nanostructures comprising hollow nanospheres and nanotubes for use as chemical sensors, conduits for fluids, and electronic conductors. The nanostructures can be used in microfluidic devices, for transporting fluids between devices and structures in analytical devices, for conducting electrical currents between devices and structure in analytical devices, and for conducting electrical currents between biological molecules and electronic devices, such as bio-microchips. | 2012-02-23 |
20120045755 | HER-2 BINDING ANTAGONISTS - There is disclosed a pharmaceutical composition for treating solid tumors that overexpress HER-2, comprising an agent selected from the group consisting of (a) an isolated polypeptide having from about 50 to 79 amino acids taken from the sequence of SEQ ID NO. 1 or SEQ ID NO:12, wherein the polypeptide binds to the extracellular domain ECD of HER-2 at an affinity of at least 10 | 2012-02-23 |
20120045756 | METHODS AND COMPOSITIONS FOR SEQUENCE-SPECIFIC PURIFICATION AND MULTIPLEX ANALYSIS OF NUCLEIC ACIDS - Methods and materials for determining the presence of at least one nucleic acid in a sample are provided, said methods comprising (1) a purification step using sequence specific hybrid capture; (2) an amplification step; and (3) a detection step comprising contacting the target nucleic acid with a plurality of detectably labeled nucleic acid detection probes, wherein each (a) bears a different detectable label from the other detection probes, and/or (b) has a different melting temperature from probes bearing the same detectable label. Also disclosed are compositions and kits for use in such a method. | 2012-02-23 |
20120045757 | APPARATUS AND METHODS FOR ANALYSING FLUORESCENT PARTICLES - According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample. | 2012-02-23 |
20120045758 | IMPRINTING IN VERY SMALL EMBRYONIC-LIKE (VSEL) STEM CELLS - Methods for determining a degree of pluripotency in a first putative stem cell relative to a second putative stem cell are provided. In some embodiments the methods include comparing the imprinting status in the first versus the second putative stem cell of a locus selected from among Igf2-H19, Rasgrf1, lgf2R, Kcnq1, and Peg1/Mest. Also provided are methods for distinguishing very small embryonic like (VSEL) stem cells from hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), methods for isolating VSELs from sources expected to include VSELs, methods for assessing the purity of a very small embryonic like stem cell (VSEL) preparation, and kits that include oligonucleotide primers that can be employed in the practice of the claimed methods. | 2012-02-23 |
20120045759 | Methods for detecting nucleic acid hybridization - Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens. | 2012-02-23 |
20120045760 | Single Nucleotide Polymorphism Within An Intronic P53 Binding Motif of the Prkag2 Gene - The present invention relates to single nucleotide polymorphism (SNP). In particular, it relates to a SNP within an intronic p53 binding motif of the PRKAG2. Nucleic acid molecules and methods for aiding assessment of a patient's risk of developing cancer by determining the patient's genotype for a p53 binding motif within the PRKAG2 gene are included in the present invention. | 2012-02-23 |
20120045761 | PROBES AND PRIMERS FOR DETECTION OF CHIKUNGUNYA - The present disclosure gives a detailed description of methods for determining the presence of Chikungunya viral nucleic acids in blood/serum/plasma samples by employing “Oligonucleotide” probes. The designed “Oligonucleotide” probes can be used for qualitative or quantitative detection of Chikungunya virus in an infected sample by employing Real time PCR. | 2012-02-23 |
20120045762 | LMNA GENE AND ITS INVOLVEMENT IN HUTCHINSON-GILFORD PROGERIA SYNDROME (HGPS) AND ARTERIOSCLEROSIS - Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal protein. In addition to the novel Lamin A variant protein and nucleic acids encoding this variant, methods of using these molecules in detecting biological conditions associated with a LMNA mutation in a subject (e.g., HGPS, arteriosclerosis, and other age-related diseases), are also described. Oligonucleotides and other compounds for use in examples of the described methods are also provided, as are protein-specific binding agents, such as antibodies, that bind specifically to at least one epitope of a Lamin A variant protein preferentially compared to wildtype Lamin A, and methods of using such antibodies in diagnosis, treatment, and screening. | 2012-02-23 |
20120045763 | Antibodies Against Cells of Fetal Origin - This invention relates to antibodies that specific bind to fetal CD36+ cells in preference to binding to maternal CD36+ cells and methods for using these antibodies to detect and separate fetal cells from adult biological fluids including maternal peripheral blood. | 2012-02-23 |
20120045764 | METHOD OF EXPANDING HUMAN HEPATOCYTES IN VIVO - Described herein is a method of expanding human hepatocytes in vivo using an immunodeficient mouse which is further deficient in fumarylacetoacetate hydrolase (Fah). The method comprises transplanting human hepatocytes into the immunodeficient and Fah-deficient mice, administering an IL-1R antagonist to the mouse and allowing the hepatocytes to expand. Alternatively, the method includes transplanting human hepatocytes into the immunodeficient and Fah-deficient mice, wherein the mouse is further deficient for IL-1R and allowing the hepatocytes to expand. The method also allows serial transplantation of the human hepatocytes into secondary, tertiary, quaternary or additional mice. | 2012-02-23 |
20120045765 | COMPOSITE LIQUID CELLS - A sample handling method may include drawing an encapsulating liquid from an encapsulating-liquid input; discharging the drawn encapsulating liquid (a) onto a free surface of a carrier liquid in a carrier-liquid conduit comprising a stabilisation feature and (b) proximate to the stabilisation feature, the encapsulating liquid being immiscible with the carrier liquid, so that the discharged encapsulating liquid does not mix with the carrier liquid, floats on top of the carrier liquid, and is immobilised by the stabilisation feature; drawing a sample liquid from a sample-liquid input; and discharging the drawn sample liquid, the sample liquid being immiscible with the encapsulating liquid and with the carrier liquid, so that the sample liquid does not mix with the encapsulating liquid or with the carrier liquid. | 2012-02-23 |
20120045766 | JARID1B FOR TARGET GENE OF CANCER THERAPY AND DIAGNOSIS - The present invention relates to the roles played by the JARID1B genes in cancers and features a method for treating cancers by administering a composition comprising a double-stranded molecule against the JARID1B genes or a vector encoding them. The present invention also features methods for diagnosing cancers by detecting the expression of JARID1B. To that end, JARID1B serves as a serological biomarker for cancers. Also, disclosed are methods of identifying candidate agents for treating or preventing cancer or inhibiting cancer cell growth, using the expression of JARID1B in the cancer cells or the cell proliferation resulted from expression of JARID1B as an index. | 2012-02-23 |
20120045767 | MAGNETIC BEADS HAVING SURFACE GLYCOCONJUGATES AND USE THEREOF - Magnetic beads that include polyvalent ligands comprising various carbohydrates are described. Methods for fabricating such magnetic beads are also provided as well as methods of their use to capture and enrich pathogen cell population for subsequent culture, lysis and identification. | 2012-02-23 |
20120045768 | METHODS AND COMPOSITIONS TO DETECT AND DIFFERENTIATE SMALL RNAS IN RNA MATURATION PATHWAY - Methods to specifically detect and differentiate one or more small RNAs in miRNA maturation pathway. | 2012-02-23 |
20120045769 | CELLULAR ASSAY EMPLOYING DETECTABLE PROTEIN - Provided herein are assays useful, for example, for determining the activity of a protein involved in a cellular process. In some embodiments, the activity of the protein is assessed using a nucleic acid tag, and in particular, by detecting the presence of a nucleic acid tag. Such assays can be used, for example, to study the effects of test compounds as modulators, e.g., inhibitors, agonists and antagonists, of protein activity. | 2012-02-23 |
20120045770 | LUNG TISSUE MODEL - The present invention provides for an engineered three dimensional (3D) pulmonary model tissue culture which is free of any artificial scaffold. | 2012-02-23 |
20120045771 | METHOD FOR ANALYSIS OF NUCLEIC ACID POPULATIONS - The invention relates to a method for isolation of target molecules from a nucleic acid population. | 2012-02-23 |
20120045772 | Affinity Hydrogel and Label Independent Detection Methods Thereof - A biosensor article including a substrate having polymer modified surface, the polymer comprising the formula (I) | 2012-02-23 |
20120045773 | CELL ADHESION INHIBITOR AND APPLICATIONS THEREOF | 2012-02-23 |
20120045774 | Lipoprotein Associated Phospholipase A2, Inhibitors Thereof and Use of the Same in Diagnosis and Therapy - The enzyme Lp-PLA | 2012-02-23 |
20120045775 | PHOSPHOSPECIFIC PAK ANTIBODIES AND DIAGNOSTIC KITS - The present invention relates to the use of phosphorylated p21-activated protein kinases (PAK), especially PAK4, as biomarkers of tumorogenesis. The present invention contemplates the use of phosphospecific antibodies for detecting phosphorylated PAK from mammalian biopsies, as well as screening assays for identifying compounds that modulate PAK activity. Also contemplated is a method for determining a subset of a given population that is amenable to treatment with a compound that modulates PAK activity. | 2012-02-23 |
20120045776 | MONOCLONAL ANTIBODY DS6, TUMOR-ASSOCIATED ANTIGEN CA6, AND METHODS OF USE THEREOF - The present application describes a monoclonal antibody selected from the group consisting of monoclonal antibody DS6, monoclonal antibodies that specifically bind to the antigen or epitope bound by monoclonal antibody DS6, and fragments of the foregoing that specifically bind to the antigen or epitope bound by monoclonal antibody DS6. Methods of use of such antibodies and the isolated antigen bound by such antibodies are also described. | 2012-02-23 |
20120045777 | NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES - The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes. | 2012-02-23 |
20120045778 | ELISA FOR HAPTOGLOBIN-MATRIX METALLOPROTEINASE 9 COMPLEX AS A DIAGNOSTIC TEST FOR CONDITIONS INCLUDING ACUTE INFLAMMATION - A method for detecting a haptoglobin-matrix metalloproteinase 9 (Hp-MMP9) complex in a biological sample. The sample includes incubating the biological sample with a capture reagent immobilized on a solid support to bind Hp-MMP9 to the capture reagent. The capture reagent includes a monoclonal antibody that binds MMP9. The method detects Hp-MMP9 bound to the immobilized capture reagent by contacting the bound Hp-MMP9 with a detectable antibody that binds to Hp. | 2012-02-23 |
20120045779 | METHOD FOR DIAGNOSING ENDOMETRIOSIS AND DIAGNOSTIC KIT FOR ENDOMETRIOSIS - It is an object of the present invention to provide: a method for determining endometriosis, in which a blood sample from a subject can be used, and which is capable of determining endometriosis with higher sensitivity and higher precision than those of a conventional method using only a conventional endometriosis marker such as CA125; and a diagnostic kit for carrying out the method of the present invention. The method for determining endometriosis according to the present invention comprises: a step of analyzing an expression of at least one selected from among an anti-syntaxin autoantibody, an anti-PDIK1L autoantibody and an anti-enolase autoantibody; and a step of determining the presence or absence of the onset of endometriosis based on results of said expression analysis. | 2012-02-23 |
20120045780 | SIGNAL BIOMARKERS - Diagnostics relating to C-type natriuretic and erythropoietin signal peptides and fragments, and kits, uses and applications therefor. | 2012-02-23 |
20120045781 | PATHOLOGY BIOMARKER ASSAY - Methods of diagnosis or of quantitation of pathological conditions comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a biofluid sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of pathology. The immunoassay is conducted by a method comprising: contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope. Neo-epitopes from, collagen type I, collagen type III, collagen type IV, collagen type V, collagen type VI, elastin, biglycan, decorin, lumican, versican, C-reactive protein, ApoE and laminins are described. | 2012-02-23 |
20120045782 | IMATINIB IMMUNOASSAY - Novel conjugates and immunogens derived from imatinib and monoclonal antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of imatinib or its pharmacologically active salts in biological fluids. | 2012-02-23 |
20120045783 | Method of determining tropomyosin in chitosan - A method capable of easily determining with high accuracy a protein in chitosan, the protein having a potential relevance to the development of an allergy, specifically tropomyosin and the content of the peptide. According to the method, tropomyosin is determined by immunoassay with the chitosan being in a state dissolved in an aqueous solution of an organic acid. The method also provides chitosan, which has a measurement value of the protein, specifically tropomyosin, not higher than a predetermined value as measured by the determination method and is assessed to have only a low risk of inducing the allergy. | 2012-02-23 |
20120045784 | BIOTINIDASE ASSAY - The present technology discloses biotinidase assay, biotinidase substrates (I) and a kit wherein the biotinidase substrate includes a label molecule separated from the biotin carbamoyl group by a linker X longer than about 4 Å but shorter than about 27 Å. | 2012-02-23 |
20120045785 | Hybrid Prokaryotic-Eukaryotic Tubulins and Use Thereof - The present invention embraces hybrid | 2012-02-23 |
20120045786 | OPTO-FLUIDIC MICROSCOPE DIAGNOSTIC SYSTEM - An image sensor integrated circuit may contain image sensor pixels. Channels containing a fluid with cells or other material may be formed on top of the image sensor. The image sensor pixels may form imagers. Each imager may be located in a respective one of the channels. Reactant chambers may be used to expose the particles in the fluid to reactant. The imagers may gather images of the cells or other particles as the fluid passes over the imagers following exposure to the reactant. Spent sample chambers at the ends of the channels may be used to collect the fluid after the fluid has passed over the imagers. Image data from the imagers may be processed by control circuitry on the image sensor integrated circuit and external equipment. | 2012-02-23 |
20120045787 | FLEXIBLE MICRO-CARRIER SYSTEM - Micro-carrier systems may be used to carry and identify sample materials through an analysis system. Analysis systems may include an image sensor integrated circuit containing image sensor pixels. A channel containing a fluid with particles such as cells may be formed on top of the image sensor. Micro-carriers may be used to carry the cells in the fluid. Micro-carriers may have identifier regions and active regions. Identifier regions may include coded information identifying cells, fluid samples, or other materials carried in the active region. Active regions may carry reagents, trapping agents, cells or other sample materials. Active regions may be formed on a surface of a micro-carrier or may be formed in a cavity inside the micro-carrier. Micro-carriers may include magnetic control structures that can be used to guide, rotate, accelerate or position micro-carriers. | 2012-02-23 |
20120045788 | Device for sample preparation - A pipette tip or tube containing chromatographic media contained and held in place in said tube by using low melting point porous polymer particles. Such pipette tips or tubes can be used for sample preparation, filtration and synthesis of small molecules and biomolecules. | 2012-02-23 |
20120045789 | Method for Screening of Antiviral Agents - A method for screening for an antiviral agent capable of blocking a viral viroporin by determining whether a test agent can rescue expression of a fragment of a viral viroporin in a Single Protein Production system of | 2012-02-23 |
20120045790 | MICRODISSECTION METHOD AND INFORMATION PROCESSING SYSTEM - In a first aspect, a method for use in biology, histology, and pathology, comprises: providing a digital first image ( | 2012-02-23 |
20120045791 | METHOD AND A BLOOD OXYGEN TESTER FOR DETECTING THE ARTERIAL OR VENOUS BLOOD - A method and a blood oxygen tester for determining whether a blood sample is arterial or venous blood are disclosed. A blood oxygen tester for determining whether a blood sample is arterial or venous blood includes a housing and a blood sample receptacle defined by the housing. A blood oxygen sensor is in communication with the blood sample receptacle and a test result indicator is in communication with the blood oxygen sensor. The indicator is responsive to the blood oxygen sensor for indicating whether a tested blood sample is arterial blood or venous blood. | 2012-02-23 |
20120045792 | DRIED BLOOD SPOTTING PAPER DEVICE AND METHOD - A dried blood-spotting device includes a carrier card having a window therethrough along with a punchable glass fiber paper disposed in the window for a uniform absorption of a blood droplet sample into a homogeneous circular sport. The glass fiber paper is configured for enabling improved analysis for small molecules by a liquid chemotography/mass spectroscopy of punched specimens of the sample absorbed glass fiber paper. | 2012-02-23 |
20120045793 | EXPRESSION CONSTRUCTS COMPRISING FUNGAL PROMOTERS - The present invention provides promoters derived from a filamentous fungus. These promoters have application in the fields of molecular biology, microbiology, fungal genetics and production of biofuels and other products. | 2012-02-23 |
20120045794 | PREPARATION OF PROTECTIVE ANTIGEN - A polynucleotide sequence is provided comprising a nucleic acid sequence encoding recombinant Protective Antigen (rPA). | 2012-02-23 |
20120045795 | METHOD FOR PRODUCING A CELL CAPABLE OF HIGH-YIELD PRODUCTION OF HETEROPROTEINS - The present invention provides a cell capable of high-yield production of polypeptides and a method for producing the same. | 2012-02-23 |
20120045796 | NUCLEIC ACID HOTSTART TECHNOLOGY - The present invention relates to molecules used as hotstarts for polymerases, including among others the DNA polymerase and reverse transcriptase. | 2012-02-23 |
20120045797 | NUCLEIC ACID AMPLIFICATION PROCEDURE - The invention provides methods for amplification of polynucleotide sequences using primers containing single-Cstranded RNA. The methods employ use of an enzyme capable of cleaving single-stranded RNA, such as RNase I, to degrade a first RNA-containing primer prior to addition of a second RNA-containing primer. The invention also provides compositions and kits pl. for practicing the amplification methods, as well as methods which use the amplification products. | 2012-02-23 |
20120045798 | METHOD AND DEVICE FOR ELECTROWETTING GENETIC ANALYSIS - It relates to a method for amplifying at least one nucleotide molecule contained in a sample (E) comprising the following successive steps consisting of (a) subjecting said sample (E) to a 1st amplification step on an area (Z | 2012-02-23 |
20120045799 | THERMOCYCLER SEAL COMPOSITION, METHOD, AND APPLICATION - An immiscible mixture of wax and silicone oil is provided for application to the inner surface of a thermocycle reactor tube. The mixture is a solid at typical room temperatures and under typical product storage conditions, but at temperatures above the melting point of the mixture (e.g., >46° C. and therefore, at or above 90° C. (which is typical of the first stage of a PCR thermocycle)) the mixture melts and covers the exposed surface of the solution undergoing the thermocycle, thereby sealing the reaction against evaporation and/or condensation over the duration of the multiple thermocycles typical of a PCR reaction. Upon cooling of the reaction tube, the resulting amplicons can then extracted from below the sealing layer. | 2012-02-23 |
20120045800 | Microalgae Biofuel Production System - A system for processing oil from algae is disclosed. Specifically, the system recycles byproducts of the process for use as nutrients during algae growth and oil production. The system includes a conduit for growing algae and an algae separator that removes the algae from the conduit. Also, the system includes a device for lysing the algae and an oil separator to remove the oil from the lysed matter. Further, the system includes a biofuel reactor that receives oil from the oil separator and synthesizes biofuel and glycerin. Moreover, the algae separator, oil separator and biofuel reactor all recycle byproducts back to the conduit to support further algae growth. | 2012-02-23 |
20120045801 | RECOMBINANT RALSTONIA EUTROPHA CAPABLE OF PRODUCING POLYLACTIC ACID OR POLYLATIC ACID COMPOLYMER, AND METHOD FOR PRODUCING POLYLACTIC ACID OR POLYLATIC ACID COPOLYMER USING SAME - Provided are a recombinant | 2012-02-23 |
20120045802 | Liquid fractionation method for producing biofuels - A method for producing biofuels is provided. A method of making biofuels includes dewatering substantially intact algal cells to make an algal biomass, sequentially adding solvent sets to the algal biomass, and sequentially separating solid biomass fractions from liquid fractions to arrive at a liquid fraction comprising neutral lipids. The method also includes esterifying the neutral lipids, separating a water miscible fraction comprising glycerin from a water immiscible fraction comprising fuel esters, carotenoids, and omega-3 fatty acids. The method also includes obtaining a C16 or shorter fuel esters fraction, a C16 or longer fuel ester fraction, and a residue comprising carotenoids and omega-3 fatty acids. The method includes hydrogenating and deoxygenating at least one of (i) the C16 or shorter fuel esters to obtain a jet fuel blend stock and (ii) the C16 or longer fuel esters to obtain a diesel blend stock. | 2012-02-23 |
20120045803 | METHOD FOR PRODUCTION OF SUBSTANCE IN CANDIDA UTILIS USING XYLOSE AS CARBON SOURCE - Disclosed is a yeast strain of | 2012-02-23 |
20120045804 | CONVERSION OF HEXURONIC ACID TO HEXARIC ACID - The present invention relates to a method and microbial host strain for converting a hexuronic acid to a hexaric acid. In particular, the invention relates to the con-version of D-galacturonic acid to meso-galactaric acid (mucic acid). The invention also concerns an isolated nucleotide sequence. According to the present method a microbial host strain genetically modified to express uronate dehydrogenase enzyme (EC 1.1.1.203) is contacted with a biomaterial comprising hexuronic acid and the con-version products are recovered. By using the recombinant microorganisms of the present invention it is possible to treat biomaterials comprising hexuronic acids and thereby decrease the amount of hexuronic acids released to the environment. | 2012-02-23 |
20120045805 | SYSTEM AND METHOD FOR THE SYNTHESIS OF THERMOPLASTIC BIOPOLYMER - The various embodiments herein provide a system and a method of synthesis of thermoplastic biopolymer such as poly-β-hydroxy butyric acid wherein the activated sludge and synthetic waste water are acclimatized in a sequential batch reactor. The diazotrophs are reacted with CO | 2012-02-23 |
20120045806 | ENZYMATIC SYNTHESIS OF NOOTKATONE - Polypeptide with an amino acid sequence according to SEQ ID No. 1 or a variant in which up to 10% of the amino acids have been altered by insertions, deletions or substitution. | 2012-02-23 |
20120045807 | PROCESS FOR PRODUCING CHEMICALS USING MICROBIAL FERMENTATION OF SUBSTRATES COMPRISING CARBON MONOXIDE - A process for converting a substrate such as carbon monoxide to useful chemicals has been developed. The process involves providing a substrate comprising CO to a bioreactor which contains a culture of one or more micro-organisms and anaerobically fermenting the substrate to produce 2,3-butanediol (BDO). The BDO is next converted to one or more of butane, butadiene and/or methyl ethyl ketone which in turn can be converted to other compounds. The source of the CO can be an industrial process such as the ferrous metal products manufacturing. The microorganism can be | 2012-02-23 |
20120045808 | PRODUCTION METHOD FOR 1,3-PROPANEDIOL USING RECOMBINANT MICROBIAL STRAIN HAVING GLYCEROL OXIDATION METABOLIC PATHWAY BLOCKED - Provided is a method of producing 1,3-propanediol by culturing a recombinant strain in which the glycerol oxidative pathway had been blocked, and more particularly a method of producing 1,3-propanediol by two-step culture of a recombinant strain in which the oxidative pathway that produces byproducts in the glycerol metabolic pathway had been blocked. When the recombinant strain in which the glycerol oxidative pathway that produces byproducts had been blocked is cultured in two steps, 1,3-propanediol can be produced with improved yield without producing products that result in an increase in purification costs. | 2012-02-23 |
20120045809 | Engineered Microorganisms for the Production of One or More Target Compounds - The present invention provides recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms comprise isobutanol producing metabolic pathway with one or more isobutanol pathway enzymes localized in the mitochondria. In various embodiments described herein, the recombinant microorganisms may be Crabtree-negative yeast microorganisms, microorganisms of the | 2012-02-23 |
20120045810 | METHOD FOR PRODUCTION OF BIO-ETHANOL USING WATERMELON SEEDS - Provided is a method for production of bioethanol using watermelon seeds and, more particularly, a method for producing bioethanol with high production yield using watermelon seeds, including: sterilizing watermelon seeds, which are usually discarded as food waste from domestic houses, supermarkets, farm houses, etc., at 121° C. for 10 to 20 minutes under anaerobic conditions; finely grinding the sterilized watermelon seeds; adding glacial acetic acid to the ground seeds to remove linoleic acid therefrom; and inoculating the treated seeds free from linoleic acid with a strain for ethanol fermentation such as | 2012-02-23 |
20120045811 | EGVII Endoglucanase and Nucleic Acids Encoding the Same - The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVII, recombinant EGVII proteins and methods for producing the same. | 2012-02-23 |
20120045812 | PRODUCTION OF ISOPRENE UNDER NEUTRAL pH CONDITIONS - Embodiments of the present disclosure relate to a process for producing isoprene from a starch substrate by saccharification and/or fermentation. The saccharification is effectively catalyzed by a glucoamylase at a pH in the range of 5.0 to 8.0. At a pH of 6.0 or above, the glucoamylase possesses at least 50% activity relative to its maximum activity. The saccharification and fermentation may be performed as a simultaneous saccharification and fermentation (SSF) process. | 2012-02-23 |
20120045813 | GENE ENCODING A PROTEIN HAVING AN ABILITY TO ENHANCE A SELENATE REDUCTION ACTIVITY - According to the present invention, a protein having an ability to enhance a selenate reduction activity, a gene encoding it, and a method for selenate reduction using them are provided | 2012-02-23 |
20120045814 | Method of Producing Synthetic Petroleum From Coal or Hydrocarbons or From C,H or Oxygen Using a Host Microorganism - The invention relates to a method of making microorganisms capable of producing petroleum from coal, or wood or certain other fossil fuels or raw materials, wherein gene sequences responsible for such production are isolated from microorganisms capable of such production, and transfected into suitable hosts, with better productivity or viability. The invention also includes using the same process to make elemental carbon, hydrogen and oxygen from organic or inorganic sources, including natural water or salt-water sources, petroleum, coal, other fossil fuel materials or other hydrocarbon sources, including turf, grass, glucose, rubber, sapropel, sapropelites, slates and wood; and it further includes making fossil fuels from water or from carbon, hydrogen and oxygen. In the alternative, the appropriate gene sequence can be used to make probes which can be used to find other gene sequences in other microorganisms which can optimize production. | 2012-02-23 |
20120045815 | CRYSTAL STRUCTURE OF GLUTAMINYL CYCLASE - A novel crystal structures of human and murine glutaminyl cyclase (QC, EC 2.3.2.5), methods of preparing the crystals, as well as the use of said crystal structures for identifying inhibitors of human and murine glutaminyl cyclase. | 2012-02-23 |
20120045816 | Novel Glycosylated Polypeptides - Provided herein are glycosylated polypeptide compositions with substantially reduced Neu5Gc content. The glycosylated polypeptides compositions with substantially reduced Neu5Gc content can be obtained from cell sources cultured with Neu5Gc competitor or from non-human animal sources fed a diet supplemented with Neu5Gc competitor. Also provided herein are methods of treating a human subject with said compositions. | 2012-02-23 |
20120045817 | Compositions And Methods Comprising Alpha-Amylase Variants With Altered Properties - Described are compositions and methods relating to variant alpha-amylases having altered biochemical properties and advantageous performance characteristics as compared to a reference alpha-amylase. The variants are suitable for use in various industrial applications such as starch conversion, ethanol production, laundry, dishwashing, pulp and paper production, textile desizing, and/or sweetener production. | 2012-02-23 |
20120045818 | Plant-Based Production of Heterologous Proteins - Described herein are viral amplicon-based protein expression systems and methods useful for producing heterologous proteins, such as enzymes, by agroinfiltration. The methods involve producing an | 2012-02-23 |
20120045819 | BINDING MOLECULES FOR HUMAN FACTOR VIII AND FACTOR VIII-LIKE PROTEINS - It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure. | 2012-02-23 |
20120045820 | NEW ANTIBIOTIC-SENSITIVE LACTIC ACID BACTERIA STRAINS - Many probiotic Bifidobacteriacea contains an active tetW that renders the cells resistant to tetracycline. This may present a risk of a horizontal transfer of functional antibiotic genes. The present invention relates to a method of obtaining novel tetracycline-sensitive strains of the genus of Bifidobacteriacea ( | 2012-02-23 |
20120045821 | METHODS AND COMPOSITIONS FOR GENETIC ENGINEERING OF CYANOBACTERIA TO PRODUCE ETHANOL - Provided herein are compositions and methods for genetic engineering of cyanobacteria to produce ethanol. In one aspect, the present invention provides a polynucleotide construct comprising a copper ion inductive promoter and a sequence encoding a pyruvate decarboxylase (pdc) enzyme. In another aspect, the present invention provides a genetically engineered cyanobacterium comprising the polynucleotide construct of the invention, wherein the cyanobacterium is capable of producing ethanol after a period of fermentation. In yet another aspect, the present invention discloses a method of producing ethanol by genetically modifying cyanobacteria using the polynucleotide construct of the invention. | 2012-02-23 |
20120045822 | Cleaning System Comprising An Alpha-Amylase And A Protease - Described are compositions and methods involving a | 2012-02-23 |
20120045823 | Method and Apparatus for Collecting Biological Materials - A method and apparatus can separate and concentrate a selected component from a multi-component material. The multi-component material may include a whole sample such as adipose tissue, whole blood, or the like. The apparatus generally includes a moveable piston positioned within a separation container and a withdrawal tube that is operable to interact with a distal end of the collection container past the piston. Material can be withdrawn through the withdrawal tube. | 2012-02-23 |
20120045824 | Device for early diagnostics of cancer - Method of cancer treatment with direct contact between proteins secreted by cancer tumor and patient's blood T-lymphocytes including the stage of weakening during some time humoral system of immunity by medical preparation, in particular by immunodepressant against this system, without weakening cellular system of immunity. | 2012-02-23 |
20120045825 | DIAGNOSTIC TEST TAPE FOR LIQUID SAMPLES - A diagnostic test tape for liquid samples is provided comprising a flexible transport tape and a plurality of test fields applied to the transport tape that are distributed in the longitudinal direction of the tape, where said test fields comprise a detection layer and a spreading net spanning the detection layer for a planar uptake of liquid sample, wherein the spreading net is formed from a lattice-like fabric comprising fabric threads that cross at right angles. In order to prevent the fabric from arching up under tape tension it is proposed that the fabric is oriented obliquely to the transport tape such that all fabric threads run obliquely to the longitudinal direction of the tape. | 2012-02-23 |
20120045826 | KITS AND DEVICES FOR DETECTING ANALYTES - The invention provides devices that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient detection of individual microscopic targets at low magnification for highly sensitive testing. The invention does not require washing steps and thus allows sensitive and specific detection while simplifying manual operation and lowering costs and complexity in automated operation. In short, the invention provides devices that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests. | 2012-02-23 |
20120045827 | SEPARATION OF ANTIGEN-SPECIFIC MEMORY B CELLS WITH A CONJUGATED BIOPOLYMER SURFACE - The present invention provides materials and methods for the isolation of immune cells. In one embodiment, the present invention provides a device for the isolation and separation of antigen-specific memory B cells. Immune cells will be separated by flowing the cells along a ligand-conjugated biopolymer surface. The ligand may be distributed in a concentration gradient along the z-axis of the biopolymer surface. Cells that display receptors specific for the ligands on the biopolymer will interact with the ligands and roll along the surface in the fashion of leukocyte rolling. Additive adhesive interactions will cause differential cell separation and eventual immobilization. | 2012-02-23 |
20120045828 | Apparatus for Magnetic Separation of Cells - Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput. | 2012-02-23 |
20120045829 | IDENTIFICATION OF ANTIGENIC PEPTIDES FROM MULTIPLE MYELOMA CELLS - Multiple myeloma (MM) is a clonal B cell malignancy and remains essentially incurable by conventional anti-tumor therapy. Patients with MM have a median survival of only three years. MM is characterized by proliferation and accumulation of mature plasma cells in the bone marrow (BM) leading to bone destruction, BM failure, anemia, and reduced immune function. The identification of MHC Class I, HLA-A2, associated peptides presented on multiple myeloma cells is an important step in developing immunotherapies for MM. Presented here are methods for creating activated T lymphocytes that are cytotoxic to both peptide loaded T2 target cells and multiple myeloma cell lines. | 2012-02-23 |
20120045830 | STEM CELL AGGREGATE SUSPENSION COMPOSITIONS AND METHODS OF DIFFERENTIATION THEREOF - The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof. | 2012-02-23 |
20120045831 | POLY(LACTIC-GLYCOLIC)ACID CROSS LINKED ALENDRONATE (PLGA-ALN) A SHORT TERM CONTROLLED RELEASE SYSTEM FOR STEM CELL DIFFERENTIATION AND DRUG DELIVERY - The present invention relates to a bisphosphonates and synthetic polymeric carriers to form a sustained release system. The present invention also provides a method for preparing a sustained release system, comprising activation of the synthetic polymeric carriers and the cross linking reaction. The present invention further provides methods for enhancing stem cell differentiation into osteogenic lineage and chondrogenic lineage, which comprise culturing a population of stem cells in specific micro-environments. | 2012-02-23 |