08th week of 2021 patent applcation highlights part 10 |
Patent application number | Title | Published |
20210052740 | CLOTTING FACTOR VARIANTS AND THEIR USE - Disclosed herein are novel variants of clotting factors VII, VIII, and IX and their use, for example, in methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B. | 2021-02-25 |
20210052741 | GENE THERAPY METHODS AND COMPOSITIONS USING AUXOTROPHIC REGULATABLE CELLS - The present disclosure provides compositions and methods for producing and using modified auxotrophic host cells for improved gene therapy involving administration of an auxotrophic factor. | 2021-02-25 |
20210052742 | Retinal Promoter and Uses Thereof - Disclosed is a promoter for driving expression in the retina. The promoter sequence comprises at least NEFH promoter conserved region A and optionally one or more of NEFH conserved regions D, F, D1, K, B, C and E. Also disclosed are uses of the promoter for directing expression to retinal ganglion cells and uses for the treatment of ocular diseases. | 2021-02-25 |
20210052743 | CD59 FOR INHIBITING INFLAMMASOME ACTIVATION - Methods and kits are provided for inhibiting inflammasome activation in cells of a subject or an inflammation-affected eye in a subject by administering to the subject a composition including a nucleotide sequence encoding a membrane independent CD59 protein operably linked to a promoter for expression and secretion of the membrane independent CD59 protein in the cells or the inflammation-affected eye, the composition inhibiting inflammasome activation. | 2021-02-25 |
20210052744 | Bicistronic AAV Vector for RNA Interference in ALS - The present invention relates to a bicistronic expression vector for silencing a gene specifically in astrocytes and neurons, comprising two expression cassettes comprising a first and a second silencer sequence, respectively, wherein the expression of said first silencer sequence within astrocytes is regulated by an astrocyte-specific promoter and the expression of said second silencer sequence within neurons is regulated by a neuron-specific promoter. In a preferred embodiment, said first and second silencer sequences are SOD1 silencer sequences. Pharmaceutical composition comprising said bicistronic vector and the use of the same in the treatment of motoneuron diseases are further described. | 2021-02-25 |
20210052745 | GRANULOCYTE COLONY-STIMULATING FACTOR (GCSF) GENE THERAPY FOR TREATING NEUROLOGICAL DISEASES - Gene therapy using expression vectors containing a granulocyte colony-stimulating factor (GCSF) gene are able to protect cells in a cell-based as well as animal-based models for ischemic stroke | 2021-02-25 |
20210052746 | SELECTIVE HYDROGEN SULFIDE PROBE AND USES THEREOF - Provided herein is a compound of formula I: | 2021-02-25 |
20210052747 | SPECIFIC CONJUGATION LINKERS, SPECIFIC IMMUNOCONJUGATES THEREOF, METHODS OF MAKING AND USES SUCH CONJUGATES THEREOF - The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)-or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders. | 2021-02-25 |
20210052748 | NOVEL COMPOUND, ANTIINFLAMMATORY DRUG COMPRISING THE COMPOUND AND CYCLOOXYGENASE-2 INHIBITOR COMPRISING THE COMPOUND - A compound is disclosed that can be used as an anti-inflammatory agent, a cyclooxygenase-2 inhibitor, a therapeutic agent for brain diseases, or a MRI contrast medium. The compound can have the structure represented by chemical formula 1. | 2021-02-25 |
20210052749 | AMPHIPHILIC POLYMER NANO MICELLE CONTAINING POLY-3,4-DIHYDROXYPHENYLALANINE CHELATED FERRIC IONS - The disclosure discloses an amphiphilic polymer nano micelle containing poly-3,4-dihydroxyphenylalanine chelated ferric ions, in which ferric ions are chelated with a catechol structure on a side chain of a biodegradable poly-3,4-dihydroxyphenylalanine block. The disclosure also provides a method for preparing the above micelle, comprising: complexing an amphiphilic polymer containing poly-3,4-dihydroxyphenylalanine with a ferric ion compound, and obtaining the amphiphilic polymer nano micelle containing poly-3,4-dihydroxyphenylalanine chelated ferric ions through a solvent replacement method. The micelle prepared by the disclosure is used as a Fe | 2021-02-25 |
20210052750 | ASEPTIC PROCESS FOR AZIDO-FUNCTIONALIZED LIGAND CONJUGATION TO SIZE-ISOLATED MICROBUBBLES VIA STRAIN-PROMOTED AZIDE-ALKYNE CYCLOADDITION - The current inventive technology includes system, methods and compositions for the generation of a cloaked microbubble having buried-ligand architecture (BLA) that may allow the cloaked microbubble to circumvent potentially deleterious immunogenic, or other unwanted chemical responses in a host. The current inventive technology may also includes systems and methods to isolate monodisperse size populations of microbubbles for enhanced therapeutic and diagnostic applications. | 2021-02-25 |
20210052751 | Ultrasound Gel Composition - A method for conducting an ultrasound session using an ultrasound probe system includes the steps of providing an ultrasound gel for use in combination with the ultrasound probe system, the ultrasound gel defining a composition including 1-10% by weight of Carbopol; 0.001-0.02% by weight of fungistat; 0.001-0.02% by weight of NaOH; 0.001-0.02% by weight of chlorhexidine; 1-5% by weight of glycerin up; 90-95% by weight of purified water; 0.001-0.02% by weight of curacao; 0.1-0.8% by weight of aloe vera leaf juice; 0.01-0.03% by weight of citric acid; 0.001-0.02% by weight of EDTA disodium; 0.001-0.02% by weight of phenoxyethanol; 0.001-0.02% by weight of ethylhexylglycerin; and 0.001-0.02% by weight of methylisothiazolinone; and selectively applying the ultrasound gel on an ultrasound site and operating the ultrasound probe system thereon. | 2021-02-25 |
20210052752 | CONDURITOL AZIRIDINE DERIVATIVES AND USES THEREOF - The present application relates to conduritol aziridines of Formula (I), and uses thereof, for example, of | 2021-02-25 |
20210052753 | METHODS AND APPARATUSES FOR PRESSURIZED PURIFICATION AND INFUSION OF PLANT MATTER AND CELLULOSE-BASED ORGANIC CELLULAR MATERIAL - A method includes heating a vacuum chamber to a first predetermined temperature, and providing an organic plant material within the vacuum chamber. A vaporizer is heated to a second predetermined temperature, and is in fluid communication with the vacuum chamber. The vacuum chamber is evacuated to a a first predetermined, sub-atmospheric pressure using a vacuum pump. A liquid reagent is injected into the vaporizer such that the liquid reagent transforms into a gaseous/aerosolized reagent. The gaseous/aerosolized reagent is introduced into the vacuum chamber. After waiting a predetermined duration, a sterilization of the organic plant material is achieved. The vacuum chamber is then vented to atmospheric pressure, and the vacuum chamber is again evacuated, to a second predetermined, sub-atmospheric pressure, to remove a reagent residue from the organic plant material, followed by a second venting of the vacuum chamber to atmospheric pressure. | 2021-02-25 |
20210052754 | AUTONOMOUS PORTABLE UNIT FOR CLEANING, DISINFECTING AND SANITISING ALL TYPES OF OBJECT, COMPRISING A LANCE INCORPORATING A STEAM GENERATOR AND A TANK OF SANITISER TO BE SPRAYED - A portable unit having a lance incorporating a steam generator and a sanitizer tank, which can improve the sanitizing and disinfection of surfaces with steam, and having a set of lines and power supply cable and a human-machine interface, which enables the supply of the fluids and electrical energy either in situ on any local network that has a water and power supply and a centralized air-blowing/suction device, or on a user-portable module that incorporates autonomous arrangement for managing the fluids and electricity. | 2021-02-25 |
20210052755 | CHARGING AND SANITATION SYSTEM CONVERSION KIT - The invention relates to systems, devices, and methods for storing, charging, sterilizing, transporting and networking mobile computing devices, such as tablet computing devices, phones, virtual reality headsets and, more particularly to a kit for modifying an existing charging cabinet to provide ultraviolet light to sterilize the tablet computing devices, phones, virtual reality headsets. | 2021-02-25 |
20210052756 | DISPLAY APPARATUS AND CONTROL METHOD THEREOF - A display apparatus, including a display panel; a touch sensor provided on the display panel and configured to detect a user touch input; an ultraviolet (UV) light source provided on an edge portion of the display panel and configured to emit UV light to the display panel from the edge portion of the display panel; and a controller electrically connected to the display panel, the touch sensor, and the UV light source, wherein the controller is configured to, based on a determination that the user touch input is not detected, control the UV light source to emit the UV light toward the display panel. | 2021-02-25 |
20210052757 | DISINFECTION BEHAVIOR TRACKING AND RANKING - A low dose disinfection and control system that utilizes empirical and theoretical data to compare performance, sensor data, stored patterns, historical usage, use intensity indexes over time and tracking information to provide a sophisticated data collection system for disinfection. The data can be used to dynamically control UV treatment parameters. This tracking is designed to enable a learning and feedback tool that helps to modify behavior and the understanding of infection. The present invention provides a system for integrating UV treatment into products. The product may include an outer layer of UV transmissive material forming an external touch surface. The UV disinfection system includes a UV source internal to the product. In use, the internal UV source produces UV-C light that passes into and permeates the outer layer to treat the touch surface. A UV reflective layer may be disposed beneath the outer layer. | 2021-02-25 |
20210052758 | ROOM DECONTAMINATION SYSTEM, METHOD AND CONTROLLER - A room decontamination systems, controllers and methods for decontaminating a room. The room decontamination system may be a UV room decontamination system that uses UV radiation to perform a decontamination operation in the room. A controller may determine whether safe conditions for decontamination exist and initiate a decontamination operation on the basis of whether they exist. Determination of safe conditions for decontamination may be based on light actuation detection and/or sensor data, which may include presence detector data and door sensor data. Determination of safe conditions for decontamination may include a determination of whether sensors are functioning properly. The controller may also determine whether decontamination operations are required on the basis of the historical condition data, for example on the basis of whether the room has been occupied since the last decontamination operation. | 2021-02-25 |
20210052759 | SYSTEM FOR MEASURING THE TEMPERATURE IN A SEVERE ATMOSPHERE ENVIRONMENT WITH ENERGY SAVINGS - A system for measuring temperature in a sterilization autoclave includes a temperature transducer positionable inside a sterilization chamber of the autoclave and a receiver positionable outside the sterilization chamber. The receiver includes a reception antenna and a receiving electronic circuit connectable with a process controller of the autoclave. The receiving electronic circuit is configured to receive a temperature signal through the reception antenna, provide a control signal as a function of the temperature signal and transmit the control signal to the process controller. The temperature transducer includes a hermetically closable transducer housing, temperature probes, a transmission antenna, an electronic transduction circuit, a primary battery and an activation device. | 2021-02-25 |
20210052760 | PHOTOBIOMODULATION DEVICE - A light source device including a light emitting element for emitting a light having the following characteristics: a wavelength ranging from 435 to 520 nm, and a power density greater than 20 mW/cm | 2021-02-25 |
20210052761 | INCENSE MATERIAL AND METHOD OF MANUFACTURE THEREOF - A method of manufacturing an incense material includes creating a mixture having five parts sawdust powder, one part adhesive, and at least six parts water. The method further includes baking the mixture and cooling the mixture to form the incense material. | 2021-02-25 |
20210052762 | AROMA DIFFUSING SYSTEM - An aroma diffusing system according to an example embodiment includes an aroma diffusing device and a mobile device. The aroma diffusing device includes a wireless communication module. The aroma diffusing device is equipped with first through n-th aroma capsules selected among a plurality of aroma capsules, which emit respective aromatic substances having different scents from each other. The mobile device is connected to the aroma diffusing device through a wireless communication. The mobile device independently controls an intensity of the emission of the aromatic substance of each of the first through n-th aroma capsules, which are installed in the aroma diffusing device, to determine a combination of scents diffused from the aroma diffusing device. The mobile device controls the intensity of the emission of the aromatic substance of each of the first through n-th aroma capsules by digitizing the intensity to an integer value. | 2021-02-25 |
20210052763 | COMPACT DUAL-INTAKE DIFFUSER - A dual-intake diffuser that has a housing, a selectively attachable base, a selectively attachable cap, a wick, and a diffuser element. The selectively attachable base and selectively attachable cap are configured to receive a composition. The diffuser element is configured to diffuse liquid at an opening in the cap. The diffuser system may include a connector and lighting element. | 2021-02-25 |
20210052764 | AIR STERILIZER UNIT - The present invention relates to air sterilizer unit having at least one inlet and at least one outlet comprising (a) a filter housing having an interior space wherein at least one UCV light source adapted for radiating microorganisms, is located, and at least one filter with a capacity to reduce or remove microorganisms from ambient air, wherein the filter is UVC resistant and is located between the UVC light source and the at least one outlet, (b) an air transportation unit, wherein the air transportation unit is adapted to move ambient air from the at least one inlet into the filter housing, and being exposed to the UVC light and through the at least one filter, and through the at least one outlet. | 2021-02-25 |
20210052765 | AIR CLEANER SYSTEM - An air-purifier system is provided that generates an ionic wind that is comfortable for the persons in a space to obtain a comfortable environment. The air-purifier system includes an air purifier having a first electrode that has first electrode-structures where each has a first conductive area that is substantially shaped as a circular ring between a first hollow and second hollow, a second electrode that has second electrode-structures where each has a third hollow that is larger in diameter than the first hollow and is substantially shaped as a circle between a third hollow and a fourth hollow a holder to fix the electrodes with a gap therebetween, and a third electrode that has third electrode-structures where each extends along the central axis of the first and the second electrode-structure; a sensor that measures environmental data in a space where the air purifier is provided; and a controller that controls the operations of the air purifier based on the environmental data that are measured by the sensor. | 2021-02-25 |
20210052766 | CHITOSAN DRESSING FOR CONTROL OF GASTROINTESTINAL BLEEDING - The present invention relates to a biocompatible, foldable, thin profile, low mass and high surface area, chitosan dressing, optionally modified with catechol, and suitable for treating bleeding in a physiological environment, e.g. gastrointestinal tract. The characteristics and structures of the chitosan dressing are provided. Methods of making and using the chitosan dressing are also provided. | 2021-02-25 |
20210052767 | ANTIMICROBIAL FIBER COMPRISING SILVER, FABRIC AND WOUND DRESSING COMPRISING THE ANTIMICROBIAL FIBER, AND METHODS FOR MANUFACTURING THE FIBER, THE FABRIC, AND THE WOUND DRESSING - A wound dressing, including fibers containing silver ions. The fibers are manufactured by dissolving silver nitrate into a polymer solution in the substantial absence of light, and then extruding the obtained solution into fibers by wet spinning process. The silver content of the wound dressing is between 0.01-10% by weight, and preferably 0.1-7% by weight. | 2021-02-25 |
20210052768 | VITAMIN C-CONTAINING POLYCAPROLACTONE MICROSPHERE FILLER AND PREPARATION METHOD THEREFOR - The present disclosure relates to a polycaprolactone microsphere containing vitamin C, a filler including the same and a preparation method therefor. Provided is a polycaprolactone microsphere filler obtained by encapsulating vitamin C in polycaprolactone microspheres, which, when injected into a living body, exhibits a rapid collagen formation effect as well as a high tissue restoration property and maintains the effects for a long period of time, thereby showing excellent restoration or volume expansion or wrinkle improvement properties of soft tissues such as cheeks, breasts, nose, lips, and buttocks and reducing wrinkles. | 2021-02-25 |
20210052769 | RESORBABLE IMPLANTABLE DEVICE BASED ON CROSSLINKED GLYCOSAMINOGLYCANS, AND PROCESS FOR THE PREPARATION THEREOF - Disclosed is a process for the preparation of hydrogels consisting of crosslinked glycosaminoglycans, which comprises: a) reacting at least one hybrid cooperative complex obtained by heating aqueous solutions of low- and high-molecular-weight glycosaminoglycans at 80-160° C. with a diepoxide as crosslinker in a ratio with the complex ranging between 0.1 and 1 equivalents, preferably between 0.2 and 0.4 equivalents, the concentration by weight of the complex in the solution ranging between 1% and 15%, preferably between 2% and 10%; b) purifying by dialysis, ultrafiltration and diafiltration. | 2021-02-25 |
20210052770 | COMPOSITION FOR BONE GRAFTING, COMPRISING NUCLEIC ACIDS, BONE GRAFT MATERIAL AND CATIONIC POLYMER, AND BONE GRAFT KIT FOR MANUFACTURING SAME - The present invention relates to a composition for bone grafting, comprising nucleic acids, a bone graft material, and a cationic polymer, and a bone graft kit for manufacturing the same. The composition for bone grafting, of the present invention, has been confirmed to promote the formation of a cushioning force that can respond to physiological stress and the formation of new bones at grafted sites, and has been confirmed to improve bone grafting convenience, and thus is expected to be effectively usable in the treatment of bone diseases. | 2021-02-25 |
20210052771 | NANOPARTICULATE MINERALIZED COLLAGEN GLYCOSAMINOGLYCAN SCAFFOLD WITH AN ANTI-RESORPTION FACTOR - Compositions including a collagen glycosaminoglycan scaffold and osteoprotegerin are described. The compositions are useful in methods for promoting osteogenesis and attenuating bone resorption. | 2021-02-25 |
20210052772 | IMPLANTABLE DEVICE COMPRISING A TEXTILE COMPONENT COMPRISING MULTIFILAMENT YARNS AND/OR SPUN YARNS MADE OF FIBERS COMPLETELY OR PARTIALLY COATED IN CYCLODEXTRIN POLYMER - The present invention relates to an implantable device comprising a textile component at least partially coated with a host polymer coating, said host polymer coating comprises a polymer of cyclodextrin(s) and/or derivatives of cyclodextrin(s) and/or inclusion complex(es) of cyclodextrin and/or inclusion complex(es) of cyclodextrin derivatives. Advantageously, said textile component comprises multifilament yarns and/or spun yarns made of fibers, at least a part of the filaments and/or fibers each having a diameter less than or equal to 25 micrometers. | 2021-02-25 |
20210052773 | IONIC POLYMER COMPOSITIONS - The present disclosure pertains to ionic polymer compositions, including semi- and fully interpenetrating polymer networks, methods of making such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging for such articles. | 2021-02-25 |
20210052774 | FIXED-SHAPE TISSUE MATRIX AND RELATED METHODS - The present disclosure provides tissue products produced from a combination of three-dimensional biologic scaffolds and acellular tissue matrices. The tissue products may include features for suture or fixation reinforcement. The tissue products may harness various properties of different acellular tissue matrices and different three-dimensional biologic scaffolds to provide improved composite structures with desired mechanical and/or biologic properties. | 2021-02-25 |
20210052775 | METHOD OF MANUFACTURING PARTICULATE TISSUE PRODUCTS - The present disclosure relates to a method for manufacturing particulate tissue products. The methods can include cutting a sheet of tissue matrix into elongated strips. In various embodiments, the method for manufacturing particulate tissue product further includes bundling the strips and slicing the bundle into particulate tissue product. The particulates may have improved properties, such as a uniform size distribution. | 2021-02-25 |
20210052776 | MESENCHYMAL STEM CELLS OR STROMAL CELLS HARBORING MODIFIED RNAS ENCODING VEGF AND BMP POLYPEPTIDES - This disclosure relates to compositions including mesenchymal stem or stromal cells (MSCs) that harbor one or more modified RNA molecules encoding a bone morphogenetic protein (BMP), e.g., human BMP, and one or more modified RNA molecules encoding vascular endothelial growth factor (VEGF), e.g., human VEGF or VEGF-A, or first and second separate pluralities of MSCs, wherein each MSC in the first plurality of MSCs harbors one or more modified RNA molecules encoding BMP, and wherein each MSC in the second plurality of MSCs harbors one or more modified RNA molecules encoding VEGF; and a carrier, e.g., a solid or semi-solid carrier. The disclosure also relates to methods and uses of these compositions to treat bone defects. | 2021-02-25 |
20210052777 | METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DIABETES - The present invention is directed to, inter alia, a scaffold-cell construct including a biocompatible polymer (e.g., poly-l-lactic acid (PLLA) and polylactic glycolic acid (PLGA)) and recombinant cells having increased GLUT4 levels and/or activity. The invention is further directed to methods for reducing glucose levels in a subject in need thereof. Also provided are methods of producing the scaffold-cell construct of the invention. | 2021-02-25 |
20210052778 | FABRICATING A CARBON NANOFIBER YARN NERVE SCAFFOLD - A carbo nanofiber nerve scaffold includes a cylindrical helix, a bundle of aligned carbon nanofiber yarns, and a carbon nanofiber sheet. The cylindrical helix includes a surgical suture material, and the cylindrical helix defines an interior of the carbon nanofiber nerve scaffold. The bundle of aligned carbon nanofiber yarns is disposed within the interior of the cylindrical helix. The carbon nanofiber sheet is disposed around the cylindrical helix on a side of the cylindrical helix opposite of the interior. | 2021-02-25 |
20210052779 | COMPOSITIONS AND METHODS FOR PREPARING AND USING NON-IMMUNOGENIC FAST ANNEALING MICROPOROUS ANNEALED PARTICLE HYDROGELS - Non-degradable, non-immunogenic microporous hydrogel compositions are provided. Such hydrogel compositions consist of flowable hydrogel particles comprising a bioinert polymeric backbone, including for example a poly(ethylene glycol)(PEG)-based polymeric backbone, an annealing component comprising a physiologically-stable, radically polymerizable alkene, including for example methacrylamide, and a heparin compound. Methods of treating glottic incompetence and/or providing laryngeal reconstruction are also provided. Such methods consist of providing a subject suffering from glottic incompetence and/or in need of laryngeal reconstruction, and administering a non-degradable, non-immunogenic microporous hydrogel composition disclosed herein. | 2021-02-25 |
20210052780 | BIOIMPLANT - Provided is a bioimplant which is capable to inhibit the biofilm formation over a long period of time after an operation. The bioimplant of the present invention comprises a base material of metal, ceramic, or plastic and a thermal spraying film of a calcium phosphate-based material formed at least partially thereon and the silver concentration in the thermal-spray film is 0.05 wt % to 3.00 wt %. | 2021-02-25 |
20210052781 | Transfer Ring - Transfer rings for use in coating substrates and methods of utilizing same are disclosed. The transfer rings disclosed herein are useful in efficiently moving a plurality of substrates between different process chambers. For instance, the transfer rings are designed to collectively move a plurality of stents between coating and sintering chambers. | 2021-02-25 |
20210052782 | ELECTROSPUN-COATED MEDICAL DEVICES - Compositions comprising electrospun fibers and pharmaceutical agents encapsulated thereto are provided. Further, articles such as medical devices and methods of use of said fibers, including, but not limited to coating of medical tubes, are provided. | 2021-02-25 |
20210052783 | COATINGS FOR IMPLANTABLE DEVICES - Intraocular pressure sensors, systems, and methods of use. Implantable intraocular pressure sensing devices that are hermetically sealed and adapted to wirelessly communicate with an external device. The implantable devices can include a hermetically sealed housing, the hermetically sealed housing including therein: an antenna in electrical communication with a rechargeable power source, the rechargeable power source in electrical communication with an ASIC, and the ASIC in electrical communication with a pressure sensor. | 2021-02-25 |
20210052784 | OSTOMY BAG WITH A SLIPPERY SURFACE - An ostomy bag having a polymeric surface is prepared by forming a polyphenol layer on the surface, forming a silanization layer on the polyphenol layer and forming a lubricant layer entrenched over the silanization layer. The silanization layer is polymerized from a solution including: (i) a polymerizable silane or siloxane or combination thereof; (ii) a solvent; and (iii) an acid catalyst. The silanization layer comprises an array of silanes or siloxanes or a combination thereof each having ends anchored to the polyphenol layer and opposite ends extending away from the polyphenol layer. | 2021-02-25 |
20210052785 | Ear and Nose Secretion Extractor Apparatus - An ear and nose secretion extractor apparatus for removing mucus and cerumen includes a headband configured to be worn on a crown of a user's head. A housing is coupled to the headband and defines a housing cavity. A pump and a battery are coupled to the housing within the housing cavity. A nasal arm is coupled to the housing. A pair of nasal collection chambers is coupled to the nasal arm. A pair of nasal nozzles is coupled to the pair of nasal collection chambers. A pair of aural arms is coupled to the headband. A pair of aural collection chambers is coupled to the pair of aural arms. The pair of aural collection chambers is in fluid communication with the pump. The pump creates suction through the nasal nozzles. The pair of aural nozzles is configured to be inserted into a user's ears. | 2021-02-25 |
20210052786 | PORTABLE DEVICE WITH DISPOSABLE RESERVOIR FOR COLLECTION OF INTERNAL FLUID AFTER SURGERY FROM A PLURALITY OF SITES SIMULTANEOUSLY - A system, method, and apparatus for the collection of surgical/wound fluid from a subject patient with the capability of simultaneous fluid removal from a plurality of such wounds and/or wound through the utilization of a single pump device worn by such a patient. Such a system, method, and apparatus allow for such a single pump device to collect surgical/wound fluid within a single site collection component attached to or associated with such a single pump device. Multiple fluid transfer lines may be incorporated with the single pump device leading to such plurality of wounds and/or wound sites for greater versatility and comfort for the subject patient, as well as cleaner removal capabilities than in the standard apparatus systems and method currently undertaken within the industry. | 2021-02-25 |
20210052787 | Collection Liner - A collection liner for a medical or a surgical operation includes a closed flexible bag portion. The closed flexible bag portion has a width direction (W) and a length direction (L). The closed flexible bag portion includes an upper part of the bag portion in the length direction and a lower part of the bag portion in the length direction. The lower part of the bag portion is folded inside the upper part of the bag portion in such a manner that the entire lower volume of the lower part is upside down inside the upper part. | 2021-02-25 |
20210052788 | A SYSTEM FOR MANAGING INSTILLATION THERAPY ON MULTIPLE WOUNDS WITH A SINGLE FLUID SOURCE - A valve arrangement for administering an instillation and/or negative pressure therapy through at least a first wound dressing and a second wound dressing includes a valve arrangement including a first flow path, a first valve, a second flow path, and a second valve. The first flow path extends between a source port and a first wound dressing port structured for fluid communication with the first wound dressing. The first valve is positioned in the first flow path. The second flow path extends between the source port and a second wound dressing port structured for fluid communication with the second wound dressing. The second valve is positioned in the second flow path. | 2021-02-25 |
20210052789 | System And Method For Treating Haemorrhagic Fluid For Autotransfusion - The invention relates to a system, and the associated method for using said system, for treating haemorrhagic fluid previously taken from a patient for the purpose of autotransfusion, comprising a unit for treating ( | 2021-02-25 |
20210052790 | Breast Pump Kit - Embodiments of a breast pump kit are disclosed herein. The breast pump kit can include one or more of a breast pump shield and a breast pump milk bag. According to various embodiments, the breast pump shield can include a body portion that has a breast engagement portion that can receive at least a portion of a breast of a user. The breast pump shield also can include a suction chamber located in proximity to the breast engagement portion. Milk can pass into the suction chamber and into the breast pump milk bag. A one-way valve can prevent reverse flow of fluids from the breast pump milk bag into the breast pump shield. The breast pump kit also can include a cover that can seal the breast pump shield, if desired. | 2021-02-25 |
20210052791 | ROTARY BLOOD PUMP FOR REGULATING A HEMODYNAMIC PARAMETER SUCCESSIVELY TO DIFFERENT TARGET VALUES - A blood pump for supporting the heart may be provided that includes: a rotor with delivery elements; a rotor drive; a pressure sensor; and a regulating device that regulates a pressure or a hemodynamic parameter by means of control of the rotor drive. The pressure and/or the hemodynamic parameter may be determined by means of one or a plurality of hemodynamic sensors and/or from operating parameters of the pump. The regulating device may be suitable for regulating a hemodynamic parameter successively, such as periodically, to different target values. Using such regulation, the blood pump may be operated in an optimized manner, and operation of the blood pump may be varied in a targeted and patient-protective manner in order to attain certain goals. | 2021-02-25 |
20210052792 | VENTRICULAR ASSISTANCE ASSEMBLY WITH STABILIZED CARDIAC PUMP - A ventricular assist assembly, for assisting a heart, | 2021-02-25 |
20210052793 | CIRCULATORY SUPPORT PUMP CENTERING ANCHORING & CENTERING DEVICE - Embodiments in the present disclosure relate to an anchoring and centering device for a circulatory support pump. An exemplary apparatus comprises an expandable anchoring device extending along a longitudinal axis, wherein the expandable anchoring device is arranged about a central axis. A distal portion of the expandable anchoring device defines an annulus through which the cardiac pump can be arranged and to which the cardiac pump can be releasable coupled. A proximal portion of the expandable anchoring device is configured to circumferentially expand to an unconstrained configuration that has a cross-sectional diameter greater than a diameter of the annulus. The exemplary apparatus also includes a constraining member arranged over the expandable anchoring device to constrain the expandable anchoring device in a constrained configuration for delivery of the anchoring apparatus. | 2021-02-25 |
20210052794 | FLEXIBLE DRIVE CABLE WITH RIGID AXIAL SHAFT - Apparatus and methods are described, including a left-ventricular assist device that includes an impeller, and a frame disposed around the impeller, the frame having a length of more than 25 mm when disposed in a non-radially constrained configuration. A rigid axial shaft extends from a proximal end of the frame to a distal end of the frame. A motor is disposed outside a body of a subject, and drives the impeller to pump blood within the subject's body, by rotating. A drive cable extends from outside the subject's body to the axial shaft. The drive cable imparts rotational motion from the motor to the impeller by rotating. The drive cable is a flexible cable comprising a plurality of coiled wires. Other applications are also described. | 2021-02-25 |
20210052795 | CATHETER PUMP ARRANGEMENT AND FLEXIBLE SHAFT ARRANGEMENT HAVING A CORE - The invention relates to a flexible shaft arrangement having a flexible hollow shaft which has an end at the drive side and an end at the output side, wherein the hollow shaft is reinforced sectionally between these ends by a core extending in its interior. Stiffer and more flexible sections can hereby be selectively positioned within the shaft arrangement. | 2021-02-25 |
20210052796 | Pressure Detector - A pressure detector is provided that includes a case connectable to a flow route for liquid, and a membrane member attached inside the case and with which a liquid-phase portion to be supplied with the liquid in the flow route and a gas-phase portion to be supplied with gas are separated from each other, the membrane member being displaceable in accordance with a pressure of the liquid supplied to the liquid-phase portion, the pressure detector detecting the pressure of the liquid in the flow route by detecting a pressure in the gas-phase portion with a pressure detection sensor. The pressure detector includes a hydrophobic portion that allows gas to pass through but blocks liquid from passing through, the hydrophobic portion being provided between the gas-phase portion and the pressure detection sensor. | 2021-02-25 |
20210052797 | Pressure Detector - A pressure detector that includes a case connectable to a flow route for liquid, and a membrane member provided in the case and with which a liquid-phase portion to be supplied with the liquid in the flow route and a gas-phase portion to be supplied with gas are separated from each other, the membrane member being displaceable in accordance with a pressure of the liquid supplied to the liquid-phase portion, the pressure detector detecting the pressure of the liquid in the flow route by detecting a pressure in the gas-phase portion. The gas-phase portion has an opening through which the gas is allowed to be introduced or discharged in accordance with the displacement of the membrane member, and a secured portion secured for the introduction or discharge of the gas through the opening during the displacement of the membrane member toward a side of the gas-phase portion. | 2021-02-25 |
20210052798 | RECIRCULATING DIALYSATE FLUID CIRCUIT FOR MEASUREMENT OF BLOOD SOLUTE SPECIES - A blood based solute monitoring system for measuring at least one blood solute species that has a first recirculation flow path in communication with a dialyzer. The first recirculation flow path is configured to allow a fluid to recirculate through a dialyzer such that the concentration of at least one solute species in the fluid becomes equilibrated to the solute species concentration of the blood compartment of the dialyzer. The blood solute monitoring system has at least one sensor to measure a fluid characteristic. | 2021-02-25 |
20210052799 | Blood Purification Apparatus - A blood purification apparatus that includes a blood circuit including an arterial blood circuit provided with an arterial puncture needle and a venous blood circuit provided with a venous puncture needle with which an access vessel is puncturable, the blood circuit allowing blood of the patient to extracorporeally circulate; a blood purifier connected to the arterial blood circuit and to the venous blood circuit and that purifies the blood flowing through the blood circuit; a blood pump provided to the arterial blood circuit; a recirculating-blood-detecting unit capable of detecting recirculating blood when the blood of the patient is caused to extracorporeally circulate through the blood circuit by activating the blood pump, the recirculating blood being blood once returned to the patient from the venous blood circuit and reintroduced into the arterial blood circuit; and a recirculation-rate-calculating unit capable of calculating recirculation rate, the recirculation rate being a proportion of the recirculating blood in the blood flowing in the arterial blood circuit. The blood purification apparatus includes a control unit capable of executing a treatment mode in which blood purification treatment is performed with the blood purifier while the blood of the patient is caused to extracorporeally circulate through the blood circuit by activating the blood pump in a state of normal connection where an upstream part of the access vessel is punctured with the puncture needle at a distal end of the arterial blood circuit and a downstream part of the access vessel is punctured with the puncture needle at a distal end of the venous blood circuit; and a measurement mode in which the detection of recirculating blood by the recirculating-blood-detecting unit and the calculation of recirculation rate by the recirculation-rate-calculating unit are performed while the blood of the patient is caused to extracorporeally circulate through the blood circuit by activating the blood pump in a state of reverse connection where the downstream part of the access vessel is punctured with the puncture needle at the distal end of the arterial blood circuit and the upstream part of the access vessel is punctured with the puncture needle at the distal end of the venous blood circuit, the calculated recirculation rate being used in calculating blood flow rate in the access vessel that is calculable in the measurement mode | 2021-02-25 |
20210052800 | Pressure Detector - A pressure detector that includes a case connectable to a flow route for liquid, and a membrane member attached inside the case and with which a liquid-phase portion to be supplied with the liquid in the flow route and a gas-phase portion to be supplied with gas are separated from each other, the membrane member being displaceable in accordance with a pressure of the liquid supplied to the liquid-phase portion, the pressure detector detecting the pressure of the liquid in the flow route by detecting a pressure in the gas-phase portion. The pressure detector includes an inlet port including a connecting portion connectable to the flow route for the liquid, and a flow-route portion through which the liquid flows into an inlet opening of the liquid-phase portion; and an outlet port including a connecting portion connectable to the flow route for the liquid, and a flow-route portion through which the liquid having flowed into the liquid-phase portion is discharged from an outlet opening. At least one of the flow-route portion of the inlet port and the flow-route portion of the outlet port is configured such that an incoming direction or an outgoing direction of the liquid is inclined with respect to an attaching plane defined for the membrane member. | 2021-02-25 |
20210052801 | Pressure Detector - A pressure detector including a case connectable to a flow route and attachable to a predetermined attaching surface; and a membrane member attached inside the case and with which a liquid-phase portion to be supplied with the liquid in the flow route and a gas-phase portion to be supplied with gas are separated from each other, the membrane member being displaceable in accordance with a pressure of the liquid supplied to the liquid-phase portion, the pressure detector detecting the pressure of the liquid in the flow route by detecting a pressure in the gas-phase portion. The pressure detector includes an inlet port including a connecting portion connectable to the flow route, and a flow-route portion through which the liquid flows into an inlet opening of the liquid-phase portion; and an outlet port including a connecting portion connectable to the flow route, and a flow-route portion through which the liquid having flowed into the liquid-phase portion is discharged from an outlet opening. The outlet opening is positioned in a part of the liquid-phase portion that includes a highest point in a vertical direction in a state where the case is attached to the predetermined attaching surface, and the outlet port extends obliquely upward from the outlet opening. | 2021-02-25 |
20210052802 | SYSTEMS AND METHODS FOR IMPLODING LEUKEMIA CELLS - A system for imploding leukemia cells of a patient includes (a) a first vessel for containing a volume of blood received from the patient, and (b) drive circuitry cooperatively coupled with at least one transducer to produce ultrasound energy that spatially decoheres and disperses throughout the volume, to implode the leukemia cells throughout the volume via absorption of the ultrasound energy by the leukemia cells. The transducer may be an immersible transducer configured to be immersed in the blood. The system may include a second vessel for containing a liquid, within which the ultrasound energy is decohered and dispersed and from which at least a portion of the ultrasound energy is transmitted to the first vessel to implode the leukemia cells. | 2021-02-25 |
20210052803 | THERAPEUTIC COMPOSITIONS FOR VIRAL-ASSOCIATED DISEASE STATES AND METHODS OF MAKING AND USING SAME - A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject. | 2021-02-25 |
20210052804 | SYSTEM AND METHOD FOR IRRADIATING BIOLOGICAL FLUIDS - An irradiation device includes a fluid treatment chamber having first and second opposing sides configured to receive a biological fluid container therebetween, and at least one light source disposed adjacent at least one of the first and second sides of the fluid treatment chamber. The at least one light source includes a light guide having a front planar surface that defines in part the at least one of the first and second sides of the fluid treatment chamber, and at least one light emitting diode (LED) disposed at an edge of the light guide outside the fluid treatment chamber and configured to direct light into the light guide. The light guide has a back surface opposite the front planar surface, the back surface with one or more reflectors that depend into the light guide in the direction of the front surface. | 2021-02-25 |
20210052805 | SYSTEM AND METHODS FOR AUTOMATIC DILUTION OF WHOLE BLOOD TO INCREASE PLASMA CLARITY - A method and device are provided for centrifugally separating plasma from whole blood in which whole blood is introduced into a flow circuit having a blood access device connected to a first tubing for drawing whole blood from a blood source and for flowing whole blood to a centrifugal separation chamber; a volume of saline is added to the whole blood as it flows through the first tubing to dilute the whole blood; the volume of saline added to the whole blood is tracked; the whole blood having the volume of saline added thereto is separated in the centrifugal separation chamber so that an interface is created between the plasma and added saline and the cellular components of the whole blood; the separated plasma and added saline is flowed from the centrifugal separation chamber to a collection container; and a volume for the plasma and added saline in the collection container is determined. The device includes a programmable controller configured operate a first pump to flow saline from the container of saline through the second tubing segment to the first tubing segment, track a volume of saline flowed from the container of saline through the second tubing segment to the first tubing segment, flow separated plasma and added saline from the separation chamber through the third tubing segment to the collection container, and determine a volume for the plasma and added saline in the collection container. | 2021-02-25 |
20210052806 | APPARATUS FOR PREVENTING BACKFLOW - An apparatus for preventing backflow includes a body forming an accommodating portion which forms a transport passage of a fluid inward, wherein the accommodating portion comprises a double backflow prevention chamber to prevent backflow of the fluid, and a double backflow prevention member provided in the accommodating portion and stepwise implementing opening and closing of the double backflow prevention chamber, In particular, the accommodating portion includes an inflow chamber provided at an upper portion of the body and into which the fluid flows; a discharge chamber through which the fluid is discharged to a lower portion of the inflow chamber; and the double backflow prevention chambers respectively provided at the lower portion of the inflow chamber and the upper portion of the discharge chamber. | 2021-02-25 |
20210052807 | FLUIDIC MEDICAL TREATMENT IDENTIFICATION - Disclosed are various embodiments for identification of medical fluid treatment to a medical patient. Systems and their operations are disclosed to identify a fluidic treatment protocol among a plurality of medical infusion lines. The system includes medical infusion pumps, illuminating medical infusion lines, and computing resources to initiate identification. Fluidic medical treatment is prone to error, cognitive load is elevated in healthcare operations, the various embodiments disclosed herein are systems and methods to decrease error and reduce cognitive load by identifying as a visual cue the medical fluid treatment protocol. | 2021-02-25 |
20210052808 | METHOD FOR CALIBRATING A SYRINGE PUMP, SYRINGE PUMP AND APPARATUSES - The present disclosure describes a medical syringe pump and a method for calibrating a medical syringe pump. In some cases the medical syringe pump is configured and/or prepared to execute the method according to the present disclosure, or has been calibrated accordingly. This disclosure also describes a blood treatment apparatus which comprises such syringe pump or is connected to such syringe pump. Furthermore, the present disclosure describes a digital storage medium and/or a computer program product as a computer program. | 2021-02-25 |
20210052809 | System For Syringe Engagement To An Injector - An injector system for injecting fluid includes a syringe and an injector. The syringe includes a body and a plunger movably disposed within the body. The plunger has at least one flexible leg extending toward the rearward end of the body. The injector has a housing with a front plate, a drive member at least partially disposed within the housing and operable to engage the plunger, and a syringe release assembly operable to release the syringe. The syringe assembly includes a syringe release gear that forms an enclosure for receiving the syringe when the syringe is fully seated within the housing and a plunger release tube surrounding at least a portion of the drive member. The plunger release tube has a first end rotationally engaged with the syringe release gear. Rotation of the syringe release assembly releases the at least one flexible leg from the drive member. | 2021-02-25 |
20210052810 | FLOW RATE CONTROL DEVICE FOR SUPPLYING LIQUID CHEMICAL - Provided is a flow rate control device for supplying liquid chemicals. The device according to an embodiment of the present disclosure includes a housing unit which is placed at the location from which liquid chemicals are supplied and comprises an inflow conduit on one side to which the liquid chemicals flow in and an outflow conduit from which the flowed-in liquid chemicals whose flow rate is controlled flow out; and a control unit which is integrated with the housing unit and comprises an inflow space which comes in contact with an inflow hole at a terminal portion of the inflow conduit, an outflow space which comes in contact with an outflow hole at a terminal portion of the outflow conduit and a control path which is connected between the inflow space and the outflow space to control the flow rate of the flowed-in liquid chemicals, wherein the control path has a controlled inner diameter and a controlled length according to the flow rate a use r aims at. | 2021-02-25 |
20210052811 | THERAPEUTIC APPLICATIONS OF ARTIFICIAL CEREBROSPINAL FLUID AND TOOLS PROVIDED THEREFOR - Described herein is the use of CSF, more particularly external CSF or CSF-like compositions for the treatment and prevention of different diseases. More particularly, the application provides for the administration of CSF to the intrathecal space or the cerebral ventricles of a patient to increase intracranial pressure and/or CSF flow. | 2021-02-25 |
20210052812 | AUTO-INJECTION DEVICE - The present application discloses a device that is designed to inject into a user medicinal or non-medical substance upon activation. The device is light and compact, suitable for wearing or carrying by a user. The device comprises a needle, a syringe, and two sets of springs. The syringe comprises a plunger and a chamber for storing an injection substance. The needle is configured to be coaxial and in communication with the syringe. Each set of springs may comprise one or more springs. The first set of springs is configured to push the needle and the second set of springs is configured to move the plunger. In one exemplary embodiment, the device is enclosed in a sealed case and the device may be made to resemble a watch. | 2021-02-25 |
20210052813 | A DRUG DELIVERY SYSTEM - A drug delivery system including: an oblong housing including a setting structure to set a dose of a drug via an angular position; and a sensor structure to determine the dose, including a magnet and a magnetic sensor, arranged so that at least one of an angular position and a displacement of the magnetic sensor relative to the magnet may be determined as a function of the electrical resistance of the magnetic sensor. The sensor structure is arranged in relation to the setting structure so that the angular position of the setting structure is determined as a function of the angular position and/or the displacement of the magnetic sensor. A sensor structure is also described including: a flexible foil, including a magnetic sensor, in a cylindrical shape configuration comprising an axis; and a magnet arranged at a line parallel to or collinear with the axis. | 2021-02-25 |
20210052814 | CONTAINER FOR AN INJECTABLE MEDICAMENT - A container for an injectable medicament is provided. The container can include an elongated body having a tubular-shaped sidewall extending along a longitudinal axis and having a distal end and a proximal end. The container can include an outlet at the distal end and a bung arranged inside the elongated body, sealingly engaged with the sidewall and slidable along the longitudinal axis relative to the sidewall. The container can include an interior volume to receive the injectable medicament and being confined by the sidewall, the outlet, and the bung. The container can include a measuring arrangement arranged in or on the bung. The measuring arrangement can include a signal generator configured to emit a measurement signal into or through the interior volume, the measurement signal being capable to stimulate or to excite a resonance of the container. The measuring arrangement can include a signal detector configured to detect a feedback signal indicative of a resonating interaction of the measurement signal with at least one of the sidewall, the outlet or the interior volume. | 2021-02-25 |
20210052815 | DEVICE FOR ADMINISTERING A FLUID - A device for administering a fluid is provided, with
| 2021-02-25 |
20210052816 | PREFILLED SYRINGE AND METHOD OF STERILIZING A PREFILLED SYRINGE - A prefilled syringe is disclosed that includes a barrel, a stopper displaceable within and defining a sealed chamber in an interior of the barrel, a liquid filled in the chamber of the barrel, and a plunger extending within the barrel. The stopper expels the liquid out of the barrel via an orifice when being forwarded towards the orifice by the plunger such that a volume of the chamber is reduced. The plunger includes a proximal portion, a distal portion and a rod portion extending between the proximal portion and the distal portion. The plunger is shaped to form a pathway between an opening of the barrel and a segment where the proximal portion of the plunger is neighboring the stopper such that a sterilizing agent can be provided through the opening of the barrel to the segment where the proximal portion of the plunger is neighboring the stopper. | 2021-02-25 |
20210052817 | CONTAINER FOR AN INJECTABLE MEDICAMENT - A container for an injectable medicament can include an elongated body having a tubular-shaped sidewall extending along a longitudinal axis and having a distal end and a proximal end. The container can include an outlet at the distal end. The container can include a bung arranged inside the elongated body, sealingly engaged with the sidewall and slidable along the longitudinal axis relative to the sidewall. The container can include an interior volume to receive the injectable medicament and being confined by the sidewall, the outlet, and the bung. The container can include a measuring arrangement arranged in or on the bung. The measuring arrangement can include a signal generator configured to emit an electromagnetic measurement signal into or through the interior volume and a signal receiver configured to detect a feedback signal being indicative of an interaction of the measurement signal with at least one of the sidewall, the outlet or the interior volume. | 2021-02-25 |
20210052818 | Medical and Dental Safety Syringe - A plunging unit for a syringe is provided comprising (i) a plunger comprising a plunger head connected to a thumb rest by a shaft; and (ii) a pusher housing comprising a finger rest and an internal channel connecting a plunger-receiving end of the housing to a barrel-receiving end of the housing, wherein the plunger-receiving end is adapted to receive the plunger head into the channel and the barrel-receiving end is adapted to engage a barrel of a carpule housing unit. The plunging unit includes an aspirator comprising an actuator connected to a spring-loaded piston that is situated within the pusher housing, wherein the actuator is adjacent to the plunger-receiving end of the pusher housing such that the shaft of the plunger is moveable through the actuator and the spring-loaded piston, the actuator being moveable between a resting position and an activated position in which the actuator is pushed downwardly against the bias of the spring-loaded piston to engage with and push a carpule forward within the carpule housing unit. | 2021-02-25 |
20210052819 | DOSAGE MEASUREMENT SYSTEM - The disclosure relates to a dosage measurement system for a medicament delivery device. The medicament delivery device includes a medicament reservoir and a dispensing mechanism. The dispensing mechanism includes a dispensing member that is moveable axially to dispense medicament from the medicament reservoir. The dosage measurement system includes a sensor unit and a processor. The sensor unit is configured to measure the axial displacement of the dispensing member. The processor is configured to determine a dosage dispensed from the medicament reservoir based on the measured axial displacement of the dispensing member. | 2021-02-25 |
20210052820 | Automated Drug Delivery Systems And Methods - Automated drug delivery systems and related methods are disclosed herein. In some embodiments, these systems can reduce or eliminate infusion inconsistencies. An exemplary system can include a syringe actuator which can be controlled via electrical, mechanical, pneumatic, and/or hydraulic means to precisely infuse and/or withdraw material from a patient. | 2021-02-25 |
20210052821 | COMPLIANT TRANSMISSION SYSTEM - A compliant transmission system includes a rotatable wave generator and a sleeve fitted on the wave generator. The rotatable wave generator has an external surface including pattern extending both annularly and in a longitudinal direction. The sleeve is configured to be deformable and to be impressed on its outer surface with waves extending along the longitudinal direction during rotation of the pattern of the wave generator within the sleeve. | 2021-02-25 |
20210052822 | GLUCOSE RESPONSIVE COMPOSITE GEL COMPOSITION, METHOD FOR PRODUCING SAME, INSULIN DELIVERY MICRONEEDLE INCLUDING SAID GLUCOSE RESPONSIVE COMPOSITE GEL COMPOSITION, AND PRODUCTION METHOD THEREOF - A gel composition which can be used suitably for a microneedle that can release insulin according to the glucose concentration in a self-regulated manner and a microneedle using the same. An insulin delivery microneedle comprises a base part fabricated with silk fibroin, at least one needle part integrally provided on the base part, and an insulin reservoir. At least a tip portion of the needle part comprises a composite gel composition comprising a copolymer comprising a phenylboronic acid-based monomer unit and silk fibroin. | 2021-02-25 |
20210052823 | RECEPTACLE FOR SEVERING AND RETAINING THE NEEDLE TIP OF A HYPODERMIC SYRINGE - A receptacle for severing and retaining the needle tip of a hypodermic syringe includes a highly compact outer housing, which is shaped to define a substantially enclosed interior cavity, and a knife blade fixedly mounted within the interior cavity. The outer housing includes a flattened base and a hollow, hemicylindrical cover that are permanently secured together. In operation, the needle tip of a used syringe is inserted through coaligned, tear-shaped openings formed in both the cover and the knife blade. Through manipulation of the hypodermic syringe, the needle tip is drawn into contact with a sharpened, beveled edge that immediately defines the opening in the knife blade. Through the application of sufficient force against the sharpened edge, the needle tip is severed from the remainder of the syringe and thereby remains safely and securely retained within the interior cavity. | 2021-02-25 |
20210052824 | INJECTION DEVICE - An injection device, comprising an interface for mounting on a syringe body, the interface comprising an internal passage delimited by an inner wall, a needle and a sheath for receiving said needle, said sheath comprising an outer wall provided with a contact portion of said sheath in contact with an attachment portion of the inner wall of the interface, wherein the contact portion comprises a first bead and in that the attachment portion comprises a second bead, the first and second beads each forming a ring protruding respectively on the contact portion and the attachment portion, the first bead being in contact with the second bead. | 2021-02-25 |
20210052825 | PEN NEEDLE COVER | 2021-02-25 |
20210052826 | Rectal Injection Device And Method Of Operation Thereof - A rectal injection device configured to inject a liquid into the tissues around the internal anal sphincter of a rectum. The rectal injection device comprises: i) an elongated tube having a distal end and a proximal end; ii) a rounded head coupled to the distal end of the elongated tube; iii) a needle extending from the proximal end of the elongated tube into the rounded head, wherein a tip of the needle is aligned with a hole in the rounded head; and iv) an actuator mechanism configured to move the needle to a deployed position in which the tip of the needle extends through the hole and into the anal tissues and to move the needle to a retracted position in which the tip of the needle is withdrawn within the rounded head. | 2021-02-25 |
20210052827 | SYSTEMS AND METHODS FOR CONTROLLING NEEDLE PENETRATION - A needle adjustment device is provided. The needle adjustment device includes a stopping component and an actuator. The stopping component is configured to establish a maximum penetration depth of a needle. The actuator is fixedly coupled to the needle and movable proximally and distally to one or more positions and to adjust a penetration depth of the needle depth up to the maximum penetration depth. | 2021-02-25 |
20210052828 | CONNECTION OF A STOPPER AND PISTON IN A FLUID DELIVERY DEVICE - A device for delivering fluid to a user includes a fluid reservoir for holding the fluid, the fluid reservoir defining an internal volume and a stopper positioned in the internal volume of the fluid reservoir, wherein the stopper is formed with a cavity. The device further includes a piston having a distal end received within the cavity of the stopper and an actuator coupled to the piston for driving the piston into the internal volume of the fluid reservoir. Also, the device includes a coupling device for engaging the piston in the cavity of the stopper at a desired position and a sensor for determining whether the piston is engaged in the cavity of the stopper at the desired position. | 2021-02-25 |
20210052829 | Methods, Inhalation Device, and Computer Program - A method of controlling the generation of an aerosolised composition in an inhalation device having a heater arranged to heat an aerosolisable composition, the method comprising: controlling the power delivered to the heater such that the heater is heated from an ambient temperature to a first temperature, wherein the first temperature is below a temperature at which the aerosolisable composition is aerosolised; delivering a predetermined amount of power to the heater such that the temperature of the heater is increased from the first temperature to a second temperature, wherein the second temperature is greater than or equal to a temperature at which at least a portion of the aerosolisable composition is aerosolised. | 2021-02-25 |
20210052830 | USE OF ANTISTATIC MATERIALS IN THE AIRWAY FOR THERMAL AEROSOL CONDENSATION PROCESS - The disclosure teaches the use of antistatic materials in the airway for thermal aerosol generation devices. The present disclosure teaches the use of antistatic materials for drug delivery in any drug that may be susceptible to charging during aerosol generation. | 2021-02-25 |
20210052831 | NEBULIZER - A nebulizer capable of connecting with a mouthpiece is provided. The nebulizer includes a container, a nebulizing part, a first tube and a second tube. The container is configured to accommodate a liquid. The nebulizing part includes a chamber and a nebulizing element communicating with the container and nebulizing the liquid in the chamber. The first tube connected with the nebulizing part includes a first channel communicating with the chamber and introducing an outside airflow. The second tube is connected with the nebulizing part and the mouthpiece. A second channel of the second tube communicates with the chamber and the mouthpiece. The second tube has an expanding part at a junction of the second channel and the chamber. | 2021-02-25 |
20210052832 | INHALER WITH COMPOSITE POROUS SUPPORT ELEMENT - An inhaler article includes a body ( | 2021-02-25 |
20210052833 | MOUTHPIECE OF A NEBULIZER, AND PORTABLE NEBULIZER THEREOF - The present disclosure discloses a mouthpiece of a nebulizer, comprising an aerosol inflow port, and an aerosol outflow port; wherein an aerosol passage is formed between the aerosol inflow port and the aerosol outflow port, such that in a normal spraying state, the aerosol enters the aerosol passage from the aerosol inflow port and is discharged from the aerosol outflow port; and at least one temporary liquid reservoir is provided inside the mouthpiece, such that when condensation of the aerosol reversely flows back towards the aerosol inflow port, at least part of the condensation of the aerosol flows back into the temporary liquid reservoir. Besides, the present disclosure further discloses a portable nebulizer adopting the mouthpiece. The present disclosure provides an advantage of causing the nebulizer to produce a better anti-backflow effect. | 2021-02-25 |
20210052834 | AEROSOL-GENERATING SYSTEM COMPRISING A RUPTURING PORTION - An aerosol-generating system is provided, including an aerosol-generating device including a heater element, and an aerosol-generating article configured to engage with the aerosol-generating device, the aerosol-generating article including a medicament source, a volatile delivery enhancing compound source, and at least one frangible barrier sealing the medicament source and the volatile delivery enhancing compound source, the aerosol-generating system further including a rupturing portion forming part of the aerosol-generating device or the aerosol-generating article, the aerosol-generating system being configured to allow relative sliding movement between the rupturing portion and the at least one frangible barrier to rupture the at least one frangible barrier. | 2021-02-25 |
20210052835 | METHOD FOR CONTROLLING TEMPERATURE OF HEATER OF AEROSOL GENERATION DEVICE FOR EACH INTERVAL AND AEROSOL GENERATION DEVICE FOR IMPLEMENTING SAME METHOD - Provided is an aerosol generating device including a heater configured to generate an aerosol by heating an aerosol generating substance; and a controller configured to control power supplied to the heater, wherein the controller distinguishes a first section, a second section, and a third section and controls power supplied to the heater, and calculates a control reference ratio by using at least two from among the first section, the second section, and the third section and controls power supplied to the heater based on the calculated control reference ratio. | 2021-02-25 |
20210052836 | APPARATUS AND METHOD FOR MANIPULATING CHARACTERISTICS OF INHALED AIR - Exemplary embodiments are directed to an apparatus for manipulating one or more characteristics of air to be inhaled. The apparatus includes an outer housing including an outer surface, a hollow interior, and at least one opening formed in the outer housing and extending between the outer surface and the hollow interior. The apparatus includes a manipulation enclosure disposed within the hollow interior of the outer housing, the manipulation enclosure capable of receiving therein an air characteristic manipulation component. A substantially continuous channel is formed between the manipulation enclosure and the outer housing. | 2021-02-25 |
20210052837 | HUFF COUGH SIMULATION DEVICE - A respiratory treatment device having an inlet configured to receive exhaled air into the device, an outlet configured to permit exhaled air to exit the device, a valve moveable in response to a threshold exhalation pressure at the inlet between a closed position where the flow of air from the inlet to the outlet is restricted, and an open exhalation position where the flow of air from the inlet to the outlet is less restricted, and a valve brace configured to support the valve, wherein a position of the valve brace relative to the valve is selectively adjustable to increase or decrease the threshold exhalation pressure. | 2021-02-25 |
20210052838 | SYSTEM AND VENTILATOR FOR NONINVASIVE DETECTION OF INFECTION DURING VENTILATION - A system for noninvasive measurement of body temperature during ventilation, comprising a temperature sensor, a ventilator, an interface between ventilator and temperature sensor, a processing unit, a data storage unit, a user interface, an interface to a remote alarm, a remote alarm, a ventilation tube having a patient interface, and a respiratory gas sensor. The ventilator is configured to identify phases of inspiration and expiration by means of the respiratory gas sensor and to convey respiratory gas during inspiration and expiration. The system is configured to ascertain a sensor signal by means of the temperature sensor and the processing unit and to check whether the sensor signal is representative of body temperature and to process and/or to save such body temperature signals and to compare them with saved rules or threshold values. | 2021-02-25 |
20210052839 | ANTERIOR INTERFACE PRESSURE MONITORING DURING VENTILATION - Systems and methods for monitoring delivered interface pressure comprise measuring inhalation and exhalation data to determine a virtual delivered interface pressure by a ventilator. While air pressure delivered to a patient through NIV or HFO therapy is important to patient comfort, ventilators only directly measure inhalation and exhalation data without direct measurements of delivered interface pressure. Knowledge of the delivered interface pressure may allow clinicians to more quickly titrate inhalation flow and exhalation pressure without sacrificing patient comfort. Additionally, knowledge of the delivered interface pressure in breathing circuits with high leak rates may reduce nuisance alarms that often sound when a delivered interface pressure is unknown. Associating delivered interface pressure with adjustable inhalation and exhalation parameters may allow continued monitoring of delivered interface pressure in addition to keeping delivered interface pressure within a desired range, thus optimizing patient-ventilator interaction. | 2021-02-25 |