10th week of 2016 patent applcation highlights part 34 |
Patent application number | Title | Published |
20160069806 | Illumination of Integrated Analytical Systems - An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed. | 2016-03-10 |
20160069807 | IMAGING SYSTEM - An imaging system includes: a first lighting device for irradiating an imaging target object with visible light; a second lighting device for irradiating the imaging target object with near-infrared light; and an image sensor for photodetecting visible light caused by the visible light and coming from the imaging target object and fluorescence caused by the near-infrared light and coming from the imaging target object during a predetermined shutter open period every frame of a predetermined period. The image sensor outputs photodetection signals corresponding to photodetection amounts of the visible light and the fluorescence. The imaging system also includes a controller that generates a composite image of a visible image and a fluorescence image based on the photodetection signals, and has a lighting controller that turns on the second lighting device with optical power corresponding to the shutter open period in synchronism with the shutter open period. | 2016-03-10 |
20160069808 | FLUORESCENCE IMAGING AUTOFOCUS SYSTEMS AND METHODS - Quantitative fluorescence imaging systems and methods using angular illumination to obtain automatic focus information. Laser scanning (e.g., point or line scanning) with angular illumination in combination with an area imaging sensor, such as with a bi-telcentric scanner, is used to determine sample height (relative to a detection axis orthogonal to a platform holding the sample) and also correct for sample height in subsequent scans. | 2016-03-10 |
20160069809 | Cervical Sample Preparation For Reduced Variability In Raman Spectroscopy - A method of performing a spectroscopy process on a fixed biological sample is described. The method comprises the steps of: (i) treating the fixed biological material to cause oxidation of haemoglobin present in the fixed biological material, and (ii) performing spectroscopy on the treated fixed biological sample. The method is particularly suitable for cervical sample preparation for reduced variability in Raman spectroscopy. | 2016-03-10 |
20160069810 | SURFACE ENHANCED RAMAN SPECTROSCOPY DETECTION OF GASES, PARTICLES AND LIQUIDS THROUGH NANOPILLAR STRUCTURES - Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the nanopillars forming metallic bulbs on the top end of the nanopillars. These structures can have enhanced optical detection when functionalized with biological agents, or can detect gases, particles and liquids through interaction with the metal layer on the nanopillars. | 2016-03-10 |
20160069811 | GOLD NANOROD/POLYMER NANOCOMPOSITES AND SENSORS BASED THEREON - A nanocomposite structure includes:
| 2016-03-10 |
20160069812 | DUAL FUNCTION HEAT INDICATOR AND METHOD OF MANUFACTURE - A dual-function heat indicator for monitoring two or more modes of heat exposure is described. A manufacturing process for the dual-function heat indicator is also described. Dual-function heat indicators as described may be useful for monitoring the exposure of host products, with which the dual-function heat indicators may be associated, to cumulative ambient heat exposure and to a peak ambient heat exposure, and for other purposes. | 2016-03-10 |
20160069813 | INSPECTION OF MACHINED HOLES - A method includes obtaining an image of a feature machined in a component with an imaging device, determining, by a computing device, a quality of the feature in the component based on the image of the feature, and storing, by the computing device, an indication of the quality of the feature in combination with a unique identifier for the feature in a non-transitory computer-readable medium. | 2016-03-10 |
20160069814 | ARTICLE EDGE INSPECTION - Provided herein is an apparatus, including a photon emitter and a photon detector array. The photon emitter is configured to emit photons onto an entire surface edge of an article. The photon detector array is configured to receive scattered photons from the entire surface edge of the article, and includes a number of photon detectors. The scattered photons are photons emitted from the photon emitter that are scattered from features of the surface edge of the article. | 2016-03-10 |
20160069815 | APPARATUSES AND METHODS FOR MAGNETIC FEATURES OF ARTICLES - Provided herein is an apparatus including a photon emitter configured to emit photons onto a surface of an article. In addition, the apparatus includes a photon detector array configured to receive photons scattered from surface features and magnetic features of the article. The photon detector array is configured to provide information for mapping the magnetic features. | 2016-03-10 |
20160069816 | DEFECT DETECTION METHOD AND DEFECT DETECTION DEVICE AND DEFECT OBSERVATION DEVICE PROVIDED WITH SAME - The disclosed device, which, using an electron microscope or the like, minutely observes defects detected by an optical appearance-inspecting device or an optical defect-inspecting device, can reliably insert a defect to be observed into the field of an electron microscope or the like, and can be a device of smaller scale. The electron microscope, which observes defects detected by an optical appearance-inspecting device or an optical defect-inspecting device, has a configuration incorporating an optimal microscope that re-detects defects, and a spatial filter and a distribution polarization element are inserted at the pupil plane when making dark-field observations using this optical microscope. The electron microscope, which observes defects detected by an optical appearance-inspecting device or an optical defect-inspecting device, has a configuration incorporating an optimal microscope that re-detects defects, and a distribution filter is inserted at the pupil plane when making dark-field observations using this optical microscope. | 2016-03-10 |
20160069817 | System and Method for Detecting Heliostat Failures Using Artificial Light Sources - A system and method for detecting heliostat failures in a concentrating solar plant, the system comprising a plurality of stationary lights and cameras mounted to towers that surround, or are situated within, a field of heliostats. Heliostats may be commanded via a control system to move to a position wherein light may be expected to be reflected from a given stationary light to a given camera, whereupon a first set of images of the heliostat are taken. Heliostats may then be commanded via the control system to move to a position wherein light may no longer be expected to be reflected from said stationary light to said camera, whereupon a second set of images of the heliostat are taken. An image processor may search the first and second set of images to determine if reflected light is present. If reflected light from said stationary light is not found in the images, the heliostat may be determined to have experienced a failure mode. Failed heliostats may then be flagged for inspection, repair, or replacement. | 2016-03-10 |
20160069818 | Device and System for Monitoring the Sludge Level in a Septic Tank System - A device and system for monitoring the sludge level in a septic system tank, wherein a plurality of monitoring devices are positioned within a septic tank being monitored. Each monitoring device preferably includes a base unit, and a probe arm extending down from the base unit into the septic tank, wherein each probe arm includes a light emitting diode arm and a dark sensor photocell arm. | 2016-03-10 |
20160069819 | VEHICLE LAMP DEVICE AND ABNORMALITY DETECTOR OF LIGHT SOURCE THEREOF - An abnormality detector for a light source includes a laser diode which emits an excitation light and a fluorescent substance which is excited by the excitation light to generate a fluorescent light. The abnormality detector includes a first photo sensor which is sensitive to a wavelength of the excitation light, a second photo sensor which is sensitive to a wavelength of the fluorescent light, a first current-voltage conversion circuit which outputs a first detection signal based on an output of the first photo sensor, a second current-voltage conversion circuit which outputs a second detection signal based on an output of the second photo sensor, and a determination unit which determines whether an abnormality occurs based on the first detection signal and the second detection signal. | 2016-03-10 |
20160069820 | SYSTEM AND METHOD FOR SURFACE INSPECTION - A system includes a vessel floating on a body of water. The system also includes at least one conduit extending from the vessel to below the body of water. The system also includes a scanning device disposed within the at least one conduit. The scanning device includes at least one two-dimensional (2D) line scanner and a rotary encoder coupled to the at least one 2D line scanner. The scanning device is configured to generate three-dimensional (3D) image data of a surface of the at least one conduit or at least one component disposed within the at least one conduit. | 2016-03-10 |
20160069821 | DEVICE FOR TESTING DUCTS | 2016-03-10 |
20160069822 | METHOD AND DEVICE FOR DETERMINING AT LEAST ONE CONCENTRATION OF COAL PARTICLES IN A GAS FLOW - The present embodiments relate to a device and a method for determining at least one concentration of coal particles in a gas flow flowing through a channel, wherein at least part of the gas flow having coal particles contained therein is measured by at least one microwave sensor and at least one measurement signal characterizing the concentration of the coal particles is provided, wherein an autocorrelation function of the measurement signal is determined and at least one distance value characterizing a distance of a point of the gas flow belonging to the concentration from the microwave sensor is determined in dependence on the autocorrelation function. | 2016-03-10 |
20160069823 | METHOD AND APPARATUS FOR CONTROLLING FLUENCE IN COMPUTED X-RAY IMAGING - The present invention pertains to a system and method for X-ray imaging wherein a targeted fluence at the detector for projection images can be achieved at a plurality of projection angles around the imaging subject by control of exposure times implemented during image acquisition. Exposure time for a second projection image may be determined by the fluence in a first projection image, and in a third projection image by the fluence in a second projection image, where projection images are acquired within two degrees of one another. An acquisition parameter calculation can be configured to calculate acquisition parameters, such as said exposure times, to achieve the targeted fluence in projection images and can be coupled to a rotation controller that implements the acquisition parameters by controlling a relative angle between the imaging subject and X-ray image acquisition device. | 2016-03-10 |
20160069824 | Nonaqueous Radiopaque Fluid and Associated Imaging System and Method - An imaging system including an imaging device having a field of view, an object positioned in the field of view, the object defining a void, and a nonaqueous radiopaque fluid in the void. | 2016-03-10 |
20160069825 | METHOD AND APPARATUS FOR MEASURING SCATTERING INTENSITY DISTRIBUTION - It is an object of the present invention to provide a method and an apparatus for measuring a scattering intensity distribution capable of measuring a scattering intensity distribution in a reciprocal space in a short time. The method or apparatus for measuring a scattering intensity distribution causes X-rays emitted from an X-ray source ( | 2016-03-10 |
20160069826 | Sample Plate for An X-Ray Powder Diffraction Apparatus - A sample plate for use in an X-ray powder diffraction apparatus, the sample plate comprising a body having an exterior circumference which rotatable about a central axis, and a self contained rotating mechanism for rotating a sample holder containing a powder about a longitudinal axis, wherein the longitudinal axis intersects central axis; and wherein rotation about the central axis and rotation about the longitudinal axis occur simultaneously. | 2016-03-10 |
20160069827 | X-RAY FLUORESCENCE ANALYZER AND MEASUREMENT POSITION ADJUSTING METHOD THEREFORE - An X-ray fluorescence analyzer is provided with: a sample stage on which a sample subjected to an analysis is mounted; an X-ray source configured to irradiate the sample with primary X-rays; a detector configured to detect fluorescent X-rays emitted from the sample irradiated with the primary X-rays; an imaging unit configured to capture an image of a predetermined field-of-view area on the sample stage; a display unit configured to display the field-of-view area of the image captured by the imaging unit; and a pointer irradiation unit configured to irradiate the sample stage with a visible light at an irradiation position within an area that is outside the field-of-view area and near the field-of-view area. | 2016-03-10 |
20160069828 | HAND-HELD TEST METER WITH INTEGRATED THERMAL CHANNEL - A hand-held test meter includes an electrically and thermally insulating case (“ETIC”) with an outwardly facing surface, a test meter electrical component (“TMEC”) with a thermal contact portion disposed within the electrically-insulating case, and at least one thermal channel. The thermal channel includes a proximal contact portion with a proximal contact surface, a distal contact portion with a distal surface, and a channel portion connecting the proximal contact portion and the distal contact portion. The thermal channel is integrated with the ETIC such that the thermal channel extends through the ETIC from the outwardly facing surface and to the thermal contact portion of the TMEC. The extension is such that the proximal contact surface of the thermal channel is outside of the ETIC and the distal surface of the thermal channel is in contact with the thermal contact portion of the TMEC. The thermal channel is thermally conductive and electrically-insulating. | 2016-03-10 |
20160069829 | HARDWARE AND METHOD FOR IMPLEMENTATION OF IN SITU ACOUSTIC THERMOGRAPH INSPECTIONS - A system and method include an acoustic thermography stack and a frame that the stack is slidably mounted to. The frame includes an end frame portion with a blade stop, and an air cylinder provides force to move the stack up and down a rail of the frame such that a turbine blade may be clamped between a cap of the stack and the blade stop. The clamped blade is excited using the stack, and an infrared camera is used to detect critical indications in the blade. | 2016-03-10 |
20160069830 | CONDUCTIVITY MEASUREMENT METHOD THAT SLOWS DOWN CONDUCTOR OXIDATION - A conductivity measurement method for measuring the conductivity of a fluid in a washing chamber in an electrical washing machine using a water quality sensor consisting of a control unit and first and second conductors by alternatively changing the electric potential of the first and second conductors and repeatedly measuring the conductivity of the fluid in the washing chamber between the first and second conductors upon each electric potential alternation. | 2016-03-10 |
20160069831 | Sensor Module and Method for Producing the Sensor Module - A sensor module has a first sensor element and a second sensor element. The first sensor element and the second sensor element are accommodated in a common housing of the sensor module. The sensor module includes a conductor structure that comprises an electrode structure and a separate connection structure. The connection structure is connected in an electrically conductive manner to the first sensor element and the electrode structure is allocated to the second sensor element. | 2016-03-10 |
20160069832 | CO-FACIAL ANALYTICAL TEST STRIP WITH STACKED UNIDIRECTIONAL CONTACT PADS - An analytical test strip (“ATT”) for use with a test meter includes a first insulating layer, with a first insulating layer upper surface, and a first electrically conductive layer (“ECL”) disposed thereon. The first ECL includes a first electrode portion (“EP”) and an electrical contact pad in electrical communication with the first EP. The ATT also includes a patterned spacer layer disposed above the first ECL that includes (i) a distal portion defining a bodily fluid sample-receiving chamber therein that overlies the first EP and (ii) an insulating proximal portion with a second ECL disposed thereon. The second ECL includes an interlayer contact portion and an electrical contact pad. A third ECL of the ATT includes a second EP and a proximal portion that overlies the interlayer contact portion. The second EP is disposed overlying and exposed to the sample-receiving chamber in an opposing relationship to the first EP. | 2016-03-10 |
20160069833 | Portable Hand-Held Oxygen Monitor - A portable hand-held oxygen monitor for monitoring oxygen in a weld zone includes a user interface having an alphanumeric display and one or more user interface buttons. An audiovisual alarm includes an indicator light and an audio output device, the indicator light being separate and distinct from the alphanumeric display. The oxygen monitor implements an oxygen monitoring mode responsive to activation of one or more of the user interface buttons, wherein (1) a gas sample is obtained, (2) a digital gas sample oxygen level value is generated, and (3) the gas sample oxygen level value is compared to a stored oxygen level alarm value, and the audiovisual alarm is activated if the gas sample oxygen level value is less than the oxygen level alarm value. The activating includes illuminating the indicator light and generating sound from the audio output device to alert a monitor user that is safe to weld. | 2016-03-10 |
20160069834 | BIOSENSOR AND MOLECULAR IDENTIFICATION MEMBER - [Problem to be Solved] Provided is a higher sensitive biosensor, in which a trace amount of non-invasively collected body fluid sample can be used, and even in a case where such a trace amount of sample is used, or even in a case where the concentration of an object substance to be measured in a sample is low, the object substance can be measured with high accuracy. [Solution] A biosensor | 2016-03-10 |
20160069835 | ANALYSIS METHOD AND ANALYSIS SYSTEM - A method for analyzing a sample using capillary electrophoresis is provided. By the method, following steps are performed. First, an original sample and an anionic group-containing compound are fixed to form a mixed sample, where the original sample contains an analysis component to be analyzed and a sub component other than the analysis component. Then, an aggregate of the sub component and the anionic group-containing compound is removed from the mixed sample. Then, electrophoresis is performed in a capillary tube with respect to a complex in which the analysis component and the anionic group-containing compound are bound to each other, while the mixed sample is continuously supplied. | 2016-03-10 |
20160069836 | ION MOBILITY SPECTROMETER CHAMBER - A FAIMS ion mobility spectrometer chamber with a high repeatability of dimensions, permitting stable gas flow, mechanical rigidity, excellent thermal conductivity, and high temperature stability of gas flow. The heating resistor, ionizer electrodes, HV detector electrodes and collecting electrodes, and conducting contacts, are applied in the form of layers of precious metals on ceramic plates. The heating resistor is located on the outer surface of the top and bottom ceramic plate in the form of a resistive layer of ruthenium dioxide. On the inner surface of each of the top and bottom ceramic plates, there are gas ionizer electrodes in the form of a layer of radioactive nickel, HV electrodes and collecting electrodes, in the form of layers of gold. The conducting contacts are made of a palladium-silver layer, whereas on the edge surfaces of the ceramic plates there are edge contacts, which are made of silver paste. | 2016-03-10 |
20160069837 | OBJECT INFORMATION ACQUIRING APPARATUS - An object information acquiring apparatus includes: a matching solution that is prepared by adding, to a solvent, a solute having a higher hydrophilicity than the solvent, and propagates an acoustic wave generated from an object; a plurality of acoustic wave detection elements that receives the acoustic wave via the matching solution; a support that supports the plurality of acoustic wave detection elements so that directional axes of at least a part of the acoustic wave detection elements converge, and holds the matching solution; a position control unit that changes the positional relationship between the object and the support; and an acquisition unit that acquires characteristic information on the object based on the reception result for each positional relationship of the plurality of acoustic wave detection elements. | 2016-03-10 |
20160069838 | SYSTEM AND METHOD FOR INSPECTING FASTENERS - A fastener probe assembly includes a disc configured to rotate about a first axis of a fastener, an ultrasound probe coupled to the disc, and an encoder configured to determine an orientation of the ultrasound probe relative to the first axis of the fastener during an inspection of the fastener. The ultrasound probe is configured to interface with an axial end of the fastener, to emit ultrasound signals into the axial end of the fastener, and to receive ultrasound signals from the fastener. | 2016-03-10 |
20160069839 | SYSTEM AND METHOD FOR INSPECTING FLANGE CONNECTIONS - A system includes a probe assembly configured to inspect components of an assembled flange connection when the probe assembly is disposed within a bore of the components. The probe assembly includes a shaft configured to be aligned with an axis of the assembled flange connection, one or more ultrasound probes coupled to the shaft, and one or more encoders. The one or more ultrasound probes are configured to interface with an interior surface of the bore of the components, to emit ultrasound signals into the components, and to receive ultrasound signals from the components. The one or more encoders are coupled to the shaft and are configured to determine a position of the one or more ultrasound probes relative to a reference point of the assembled flange connection during an inspection of components of the assembled flange connection. | 2016-03-10 |
20160069840 | METHODS AND SYSTEMS TO IDENTIFY AND MANAGE RECYCLABLE MATERIALS - A method to identify and manage recyclable materials provides a recyclable material with a quartz crystal identification element configured to oscillate at a predetermined frequency associated with the recyclable material. A mobile device detects the oscillation frequency of the quartz crystal, identifies the recyclable material based on the detected oscillation frequency, and sends that information to a controller. | 2016-03-10 |
20160069841 | NOVEL SEGMENTED STRIP DESIGN FOR A MAGNETOSTRICTION SENSOR (MsS) USING AMORPHOUS MATERIAL FOR LONG RANGE INSPECTION OF DEFECTS AND BENDS IN PIPES AT HIGH TEMPERATURES - The invention relates to a continuous monitoring system which will monitor the pipes without the need of shutting down of the plants. The major issues in designing such a system using magnetostriction as per prior art is the loss of magnetization of the permanent magnets used to provide the magnetic bias and also the disbonding of interfaced adhesives with which the magnetostrictive ribbons are bonded at high temperatures. The invention identifies a novel sensor which can be taken up to high temperatures without any loss of signal strength, this is achieved by generating guided waves using a special amorphous magnetostrictive ribbons. L (0, 2) mode waves are generated using these ribbons to monitor pipes working at high temperatures as per the invention. | 2016-03-10 |
20160069842 | SYSTEM AND METHOD FOR PIPE AND CEMENT INSPECTION USING BOREHOLE ELECTRO-ACOUSTIC RADAR - An example method for pipe inspection in a subterranean formation using borehole electro-acoustic radar may include emitting mechanical energy from a mechanical energy source disposed in a pipe, which may cause the pipe to vibrate. Electromagnetic (EM) energy from an electromagnetic energy source disposed in the borehole may then be transmitted and received. A vibration signature of the medium may be identified by comparing the transmitted EM energy to the received EM energy. This may include determining the phase difference between the transmitted and received EM energy, which can be correlated to the vibration of the pipe. | 2016-03-10 |
20160069843 | Sample Disk For Ultrasonic Disk Testing Installations - A sample disc for ultrasonic disc testing equipment includes a cut-out defining a lateral face extending along a radius of the sample disc and along an axis of symmetry of the sample disc. At least one planar sample defect is created through this lateral face of the disc. | 2016-03-10 |
20160069844 | CONTROLLABLE INJECTOR SAMPLE DILUTION FOR A LIQUID CHROMATOGRAPHY SYSTEM - Described are a method and a system for injecting a sample into a flow of a liquid chromatography system. The method includes combining a flow of a sample and a flow of a mobile phase to create a diluted sample in the system flow. The volumetric flow rate of the sample is controlled to be at a value that yields a desired dilution ratio for the diluted sample. The particular value at which the volumetric flow rate is maintained can be determined from the desired value of the dilution ratio and the volumetric flow rate of the mobile phase. System embodiments include a syringe that can be used to provide a sample solution at a controllable volumetric flow rate for combination with a high pressure mobile phase. | 2016-03-10 |
20160069845 | THERMALLY MODULATED VARIABLE RESTRICTOR FOR NORMALIZATION OF DYNAMIC SPLIT RATIOS - A chromatography system includes a separation column that separates a sample carried by a compressible mobile phase flow into analytes and a splitter in fluidic communication with the separation column to receive and divide the compressible mobile phase flow into first and second mobile phase streams in accordance with a split ratio. A thermally modulated variable restrictor is coupled between the splitter and a detector. The restrictor receives the first mobile phase stream from the splitter and has a temperature element in thermal communication with the first mobile phase stream to exchange heat therewith. A controller, in communication with the restrictor, dynamically adjusts a temperature setting of the temperature element of the restrictor to adjust the heat exchange between the thermally modulated variable restrictor and the first mobile phase stream in order to keep the split ratio constant throughout a chromatographic run. | 2016-03-10 |
20160069846 | Methods and Apparatus for Analyzing Samples and Collecting Sample Fractions - Methods and apparatus for analyzing a sample using at least one detector are disclosed. | 2016-03-10 |
20160069847 | Systems And Methods To Determine Body Drug Concentration From An Oral Fluid - Oral fluid for drug testing has several advantages over other specimens: (1) It may be collected noninvasively and under direct supervision; (2) its drug concentration reflects blood-drug concentrations; and (3) it can be processed by conventional drug screening and confirmation methods. This technology provides a system that measures the quantity of a drug (without needing a priori knowledge of the drug) in an oral fluid specimen and translates this level to a blood plasma drug concentration. The method first measures the concentration of a drug in an oral fluid sample. Next, a processor calculates the blood plasma concentration from the measured oral fluid drug concentration. Finally, this blood plasma drug level is utilized to calculate a total body drug concentration. | 2016-03-10 |
20160069848 | LIQUID CHROMATOGRAPH MASS SPECTROMETER - In a liquid chromatograph mass spectrometer (LC/MS) for performing mass spectrometry of fractionated samples prepared with a multi-dimensional LC or similar LC with high separatory capability, fractionated sample useful information which shows the degree of usefulness of various substances with respect to retention time is prepared from prior information which includes, for example, elution characteristics in the LC depending on the kind of column or other factors or the degree of ease of ionization in the MS. During a measurement, the preparative separation of an eluate and the preparation of fractionated samples are not performed within a period of time which has been judged to be useless based on the fractionated sample useful information. By selecting fractionated samples at each dimension of the multi-dimensional LC, the number of fractionated samples to be eventually subjected to mass spectrometry can be significantly reduced. | 2016-03-10 |
20160069849 | OXOANION CONCENTRATION DETERMINATION USING ALUMINUM REAGENTS - To determine the concentration of an oxoanion in an aqueous solution, an aluminum reagent is added to the aqueous solution to form an optical analysis solution. Addition of the aluminum reagent may or may not form an alumino-oxoanion hydroxide hydrate precipitate. Light is directed into the optical analysis solution to determine an optical response of the optical analysis solution. Thereafter, the concentration of the oxoanion in the aqueous solution is determined based on the optical response of the optical analysis solution. For example, the concentration of the oxoanion may be calculated using a molar ratio relating oxoanion concentration to aluminum reagent concentration, when the aluminum reagent concentration corresponds to an inflection point of the optical response of the optical analysis solution. | 2016-03-10 |
20160069850 | RESONANT CO2 SENSING WITH MITIGATION OF CROSS-SENSITIVITIES - Various exemplary embodiments relate to a device to measure carbon dioxide (CO | 2016-03-10 |
20160069851 | Schema To Reduce RF Traffic and Increase the Network Capacity for Large Wireless Gas Sensor Networks - An apparatus including a wireless transceiver of the gas monitoring processor that receives gas readings and a plurality of gas detectors at different locations within the predetermined geographical area that each periodically measure a current gas level at a respective location of the gas detector wherein for each gas reading of the gas detector, a processor of the gas detector compares the current gas level with a previously measured gas level, if the current gas level is different than the previous gas level, then the gas detector wirelessly transmits a message including the current gas level to the wireless transceiver of the gas monitoring processor and if the current gas level is unchanged from the previous gas level, then the gas detector transmits a beacon message to the wireless transceiver of the gas monitoring processor as an indication that the current gas level is unchanged from the previous gas level. | 2016-03-10 |
20160069852 | Device and Process for Oil Quality Monitoring Based on Light Waves - A system and a process for detecting oil quality includes a light source configured to generate light within an oil container and a sensor configured to detect light from the light source after it has traversed through the oil in the oil container and generate an output signal. The system and process further includes a monitor configured to receive the output signal from the sensor and determine an oil quality of an oil in the oil container. | 2016-03-10 |
20160069853 | DEVICE, SYSTEM AND METHOD FOR DETERMINING THE TEMPERATURE AND ORIENTATION OF A MEDIUM - A device, system and method for remotely determining the temperature and orientation of at least one medium is provided. The device may form a body adapted to penetrate a medium, wherein the body houses a thermal sensor, an accelerometer sensor, a gyroscopic sensor, each electronically connected to a wireless transmitter extending from the body. The plurality of sensors may be adapted to determine the continuous temperature, relative position and orientation of the penetrated medium, all relative to time, while the wireless transmitter is adapted to transmit the plurality such determinations to at least one remote device. The resulting system enables a user to remotely monitoring a level of doneness for a plurality of media in terms of their respective temperatures, orientations, and positioning relative to the time spent on or in at least one heating element. | 2016-03-10 |
20160069854 | Method for Recovering Metal and Kit for Recovery of Metal for Use in the Same - A method for recovering a metal, capable of recovering a metal easily without requiring the use of an organic medium, is provided. A first complex between a first chelating agent and a metal present in a sample is formed in a first mixture prepared by mixing the first chelating agent and the sample. Then, the first complex is recovered from the first mixture, and a second complex between the metal derived from the first complex and a second chelating agent is formed in a second mixture prepared by mixing the first complex and an aqueous solution of the second chelating agent. The aqueous solution is under the pH conditions where the first chelating agent can be insoluble in the aqueous solution. Then, a liquid fraction containing the second complex is recovered from the second mixture. Thus, the metal can be recovered. | 2016-03-10 |
20160069855 | METHOD AND SYSTEM FOR DETECTION OF FUEL QUALITY USING ENGINE POWER OUTPUT AND NOx EMISSION VALUES - A method and a system for detecting a fuel quality in a vehicle including a first determination unit to determine a correction factor k | 2016-03-10 |
20160069856 | SYSTEM AND METHOD FOR MONITORING A FLUID | 2016-03-10 |
20160069857 | Evaluating Effectiveness of Ceramic Materials for Hydrocarbons Recovery - Example methods and systems are described for evaluating an effectiveness of ceramic particles to recover heavy oil from a subterranean region. In some aspects, a heavy oil recovery evaluation system includes a vessel containing a mixture of heavy oil and sand, the vessel including a chamber to receive a plurality of ceramic particles and water, a probe connected to the vessel to transfer energy from an energy source for energizing the plurality of ceramic particles, wherein the energized ceramic particles convert the water into steam to recover the heavy oil from the mixture, and a computer system connected to the vessel to evaluate an effectiveness of the plurality of ceramic particles to recover heavy oil from the mixture. | 2016-03-10 |
20160069858 | RAPID ALLERGY TESTING METHOD - The present invention provides a method for testing an allergy capable of rapidly and highly accurately testing an allergic reaction. The method can determine whether or not a patient has an allergy or whether or not an agent that may be allergenic to a patient has an allergenicity (an allergic reactivity) in the patient. The method may comprise the steps of causing migration of leukocytes separated from a healthy human or cells of an established cell line with a chemotactic factor contained in a sample such as body fluid or blood of the patient to be tested or a sample stimulated with the agent that may be allergenic to the patient and analyzing the cell kinetics such as migration velocity, migration distance, and migration direction. | 2016-03-10 |
20160069859 | MULTISTRIP CARTRIDGE - A test meter for analyzing a body fluid sample applied to a test strip includes an outer housing having an opening, an actuator, and a cartridge positioned adjacent the outer housing. The cartridge further includes a dispensing member connected to the actuator, a plurality of stacked test strips biased toward the dispensing member, and a cartridge outer housing that is adjacent at least a portion of the dispensing member. Each time the actuator is actuated, the dispensing member is rotated to cause movement of one test strip from the plurality of stacked test strips through the opening, and another test strip is biased toward the dispensing member. | 2016-03-10 |
20160069860 | ASSAYS FOR IDENTIFYING COMPOUNDS THAT MODULATE BITTER TASTE - The present invention is based on applicants' discovery, disclosed herein, of agonists for the TAS2R receptors TAS2R1, TAS2R4, TAS2R9, TAS2R13, TAS2R14, TAS2R16, TAS2R38, TAS2R39, TAS2R44, TAS2R46, and TAS2R60. The assignment of agonists to these receptors makes assays for identifying compounds that modulate bitter taste possible. For example, the present invention provides methods of identifying compounds that inhibit the bitter taste due to these agonists. The present invention also provides methods of identifying compounds that selectively inhibit the bitter taste due to these agonists. The present invention further provides methods of identifying compounds that mimic the bitter taste due these agonists. The present invention also provides methods of identifying compounds that enhance the bitter taste due to these agonists. | 2016-03-10 |
20160069861 | SENSORS AND METHODS FOR CAPTURING TARGETED CELLS - A sensor for selectively capturing a targeted cell type in a fluid includes an engineered surface. The engineered surface includes a substrate, a non-adhesive element disposed on at least a portion of a substrate, and an adhesive element disposed on the substrate. The sensor also includes a flow channel in operative contact with the engineered surface; and a detector configured to detect the targeted cell type captured on the engineered surface. Also described is a method for selectively capturing target cell types using the engineered surface. | 2016-03-10 |
20160069862 | Botulinum Assay with Synaptobrevin Substrate Moiety - Compositions and methods for analyzing intracellular BoNT protease activity, and especially BoNT/B, BoNT/G, BoNT/D, and/or BoNT/F protease activity are provided. Cells express at least two recombinant hybrid proteins each of which includes a fluorophore and a membrane anchoring peptide, and at least one of which includes a BoNT protease recognition and cleavage sequence positioned to release a fluorophore upon cleavage. Analysis is performed by monitoring fluorescence following exposure to a BoNT. | 2016-03-10 |
20160069863 | DEVICES AND METHODS FOR SINGLE CELL ANALYSIS - The present disclosure provides systems, methods, and devices for the simultaneous determination of a single cell's response to a stimuli and characterization of its cell response. The present disclosure further provides methods for detection of disease state, clinical management of a subject suffering from a disease, drug screening, prediction of drug response, and stands to help direct drug and diagnostic development for the treatment of disease. | 2016-03-10 |
20160069864 | Reagents and Methods for Cancer Treatment and Prevention - The invention generally relates to the prevention and/or treatment of cancer, and, more specifically, to the treatment of tumors, including solid tumors and their metastases, without radiation or standard chemotherapeutic agents. In one embodiment, the invention involves a method comprising: a) providing a subject with tumor cells, b) removing at least a portion of said tumor cells from said subject to create removed cells, c) treating at least a portion of said removed cells ex vivo, using stimulating agents, including thapsigargin and/or thapsigargin-related compounds, so as to create treated tumor cells; and d) introducing said treated tumor cells (or fragments thereof) in vivo into the same subject to generate anticancer therapeutic effects. | 2016-03-10 |
20160069865 | GM1 GANGLIOSIDOSIS HUMAN CELL MODEL AND USE THEREOF - The present invention relates to a method for preparing a GM1 gangliosidosis human cell model based on induced pluripotent stem cells (iPSCs) and iPSCs originated neural progenitor cells, and a use of the GM1 model above for the development of a GM1 gangliosidosis treating agent. The iPSCs originated from GM1 patient fibroblasts can be differentiated into neural progenitor cells (NPCs) and neurosphere cells that can emulate the characteristics shown in GM1 patient, so that the said cells can be efficiently used for the investigation of intracellular GM1 symptoms such as the GM1 gangliosidosis and lysosome accumulation and the gene expression pattern change. So, the GM1 cell model of the present invention can be efficiently used for the study of GM1 development mechanism and the study for the development of a therapeutic agent for the disease. The present inventors also established the inflammasome inhibitor rhIL1RA or Z-YVAD-FMK by using the above GM1 cell model and further confirmed that it can be efficiently used as a relieving/treating agent of GM1 gangliosidosis. | 2016-03-10 |
20160069866 | INHIBITION OF THE BETA3 SUBUNIT OF L-TYPE CA2+ CHANNELS - The present invention provides reagents and methods for identifying inhibitors of the L-type Ca | 2016-03-10 |
20160069867 | METHOD FOR SCREENING SKIN BARRIER FUNCTION ENHANCING AGENT BASED ON EPIDERMAL SERINE RACEMASE AND/OR D-SERINE LEVEL, AND SKIN BARRIER FUNCTION EVALUATION METHOD - The object of the invention is to develop a screening method for drugs having effects of increasing skin barrier function in in vitro experimentation, and to evaluate skin barrier function for skin. Serine racemase activity and/or expression level are used as an indicator to allow screening of candidate drugs. | 2016-03-10 |
20160069868 | MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF FIBROSIS - The present invention relates to methods and assays for identifying agents useful in the treatment of fibrotic diseases, in particular diseases related to fibroblast migration and differentiation. The invention provides polypeptide and nucleic acid TARGETs, siRNA sequences based on these TARGETs and antibodies against the TARGETs. The invention is further related to pharmaceutical composition comprising siRNA sequences based on the TARGETs and antibodies against the TARGETs for use in the treatment of fibrotic disease. The invention further provides in vitro methods for inhibition of fibroblast migration and differentiation. | 2016-03-10 |
20160069869 | Ectoparasite Detection - Ectoparasite infestation of a substrate like bedding is detected by contacting a sample from the substrate with a polyclonal ectoparasite antibody generated from a whole ectoparasite immunogen, under conditions wherein the antibody specifically binds ectoparasite antigen in the sample. | 2016-03-10 |
20160069870 | SOLID-PHASE SUPPORT, LIGAND-BINDING SOLID-PHASE SUPPORT, METHOD FOR DETECTING OR SEPARATING TARGET SUBSTANCE, AND METHOD FOR PRODUCING THE SOLID-PHASE SUPPORT - A solid-phase support, formed by binding a chain polymer at least to the surface, wherein the chain polymer is a block polymer comprising a first block constituted from repetitions of a hydrophilic structural unit and a second block constituted from repetitions of a structural unit having a reactive functional group, a content ratio of the number of moles “a” of the reactive functional group contained in the chain polymer and the number of moles “b” of the whole structural unit contained in the chain polymer, (a/b), is from 0.03 to 0.25, and a density of the chain polymer occupying the surface of the solid-phase support is 0.1 polymers/nm | 2016-03-10 |
20160069871 | MAGNETIC BEAD, LIGAND-BINDING BEAD, METHOD FOR DETECTING OR SEPARATING TARGET SUBSTANCE, AND METHOD FOR PRODUCING THE MAGNETIC BEAD - A magnetic bead, formed by binding a chain polymer at least to the surface, in which the chain polymer is a chain polymer which has a hydrophilic repeating unit, and has a group comprising a reactive functional group at the end of the side, to which the magnetic bead does not bind, through an imino group or an N-substituted imino group, and a density of the chain polymer occupying the surface of the magnetic bead is 0.1 polymers/nm | 2016-03-10 |
20160069872 | METHODS FOR CONDUCTING MULTIPLEXED ASSAYS - The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions. | 2016-03-10 |
20160069873 | FLOW CHANNEL DEVICE AND DETECTION METHOD USING SAME - A flow channel device includes a flow channel section and an introduction channel section. The flow channel section includes a flow channel in which a detection object flows and a wall surface surrounding the flow channel. The introduction channel section includes an introduction channel having a first end connected to the flow channel and a second end connected to an introduction port, and a wall surface surrounding the introduction channel. At least a part of the wall surface surrounding the introduction channel is a curved surface protruding toward the introduction channel. | 2016-03-10 |
20160069874 | ASSAY DEVICE - The disclosure relates to a method and device for detecting and quantifying biological molecules such as cell surface or intracellular ligands/receptors in a dynamic system with high sensitivity and specificity; the method of using such platform optionally in combination with an optical detection system and kits comprising the optical platform. | 2016-03-10 |
20160069875 | Labelled Silica Nanoparticles for Immunochromatographic Reagent, Immunochromatographic Test Strip Using the Same, and Immunochromomatographic Fluorescence-Detecting System or Radiation-Detecting System - Labelled silica nanoparticles for immunochromatographic reagent, comprising silica nanoparticles containing a labelled substance. | 2016-03-10 |
20160069876 | SYSTEMS, METHODS, AND WORKFLOWS FOR OPTOGENETICS ANALYSIS - The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both of the optical reporter and actuator may be based on genetically-encoded rhodopsins incorporated into the cell. The invention provides all optical methods that may be used instead of, or as a complement to, traditional patch clamp technologies and that can provide rapid, accurate, and flexible assays of cellular physiology. | 2016-03-10 |
20160069877 | Detection of Specific Antigens in a Population of Antigens - Methods for detecting the presence or absence of, and for quantifying, one set of cells in a mixed cell population of at least two sets of cells especially Rh positive cells in a mixed population with Rh negative cells, as is found in a fetal maternal hemorrhage (FMH). | 2016-03-10 |
20160069878 | SEMI-AUTOMATED WHOLE BLOOD IMMUNO-POTENCY ASSAY - The present invention relates to a rapid, semi-automated whole blood assay to quantify the potency of cultured stem cells and biologicals in inhibiting monocyte and inducing T cell activation. Such an assay allows the quantification of the anti-inflammatory potency of therapeutic stem cell products for individual patients. | 2016-03-10 |
20160069879 | METHOD FOR MEASURING ALPHA-GALACTOSIDASE CONCENTRATION - The purpose of this invention is to provide novel methods of measuring concentrations of α-galactosidase in blood, serum, plasma, cells, or tissues. For solution of this purpose, concentrations of α-galactosidase are measured using a MUSTag method in the blood, serum, plasma, cells, or tissues. | 2016-03-10 |
20160069880 | PROTEINS - The present invention relates to the identification of membrane proteins associated with B-cell non-Hodgkin's lymphoma, breast cancer, cervical cancer, colorectal cancer, gastric cancer, glioblastoma, hepatocellular carcinoma, lung cancer, lymphoid leukaemia (particularly acute T-cell leukaemia and chronic lymphocytic leukaemia), melanoma, neuroblastoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer, renal cell cancer and retinoblastoma which have utility as markers and for treatment of said cancers and which also form biological targets against which antibodies such as therapeutic antibodies (or other affinity reagents) or other pharmaceutical agents can be made. | 2016-03-10 |
20160069881 | METHODS FOR DETECTING MOLECULES IN A SAMPLE - The present invention relates to a method for detecting molecules. The method employs: at least two primary antibodies, wherein the first primary antibody binds to a first site on a molecule and the second primary antibody binds to a second site on a molecule, wherein the second site is different from the first site and wherein the first and second primary antibodies are immunologically distinct; at least two secondary antibodies, wherein the first secondary antibody is labelled with a fluorescence resonance energy transfer (FRET) donor and binds to the first primary antibody; and the second secondary antibody is conjugated or fused to an enzyme and binds the second primary antibody, wherein the first secondary antibody does not bind the second primary antibody and the second secondary antibody does not bind the first primary antibody; a conjugate comprising a FRET acceptor and a substrate specific for the enzyme, wherein when the substrate reacts with the enzyme, an activated conjugate forms, which activated conjugate binds to electron rich moieties on a molecular surface adjacent to the enzyme; wherein the method comprises: contacting a sample with the at least two primary antibodies; contacting the sample with the at least two secondary antibodies; performing a wash step; contacting the sample with the conjugate; and detecting any FRET signal generated by the FRET acceptor. | 2016-03-10 |
20160069882 | INHIBITORS OF PROTEINS SPECIFIC FOR THE SECRETOME OF A CHONDROCYTE FOR USE IN THE TREATMENT OF BREAST CANCER METASTASIS - The present invention relates to a method for identifying inhibitors of breast cancer metastasis based on a screening with proteins that are specific for the secretome of a chondrocyte, preferably cytokines and/or chemokines. The ligands as identified lead to a decrease of the migration and/or a re-differentiation of a breast cancer cell and/or a reduction of the number and/or size of breast cancer metastases. The present invention further relates to a method for detecting breast cancer metastasis, comprising the step of detecting at least one protein that is specific for the secretome of a chondrocyte, and for methods for treating and/or preventing breast cancer metastasis in a patient in need thereof, comprising the step of administering an effective amount of at least one ligand for one protein that is specific for the secretome of a chondrocyte to said patient in need thereof. | 2016-03-10 |
20160069883 | BIOMARKERS FOR DETECTION OF BREAST CANCER - Methods are provided for predicting and diagnosing the presence of breast cancer, as well as for assessing the therapeutic efficacy of a cancer treatment and determining whether a subject potentially is developing cancer. | 2016-03-10 |
20160069884 | BIOMARKERS FOR DISTINGUISHING BETWEEN AGGRESSIVE PROSTATE CANCER AND NON-AGGRESSIVE PROSTATE CANCER - The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing aggressive prostate cancer. In one embodiment, a method for identifying patients as having or likely to have aggressive prostate cancer comprises the steps of (a) performing an assay on a biological sample obtained from the patient to detect fucosylated prostate specific antigen (PSA), transmembrane prostate androgen-induced protein, kallikrein-2, lipid phosphate phosphohydrolase 3, heparan-sulfate 6-O-sulfotransferase, prostatic acid phosphatase (PAP), nuclear RNA export factor 2, and protein POF1B; and (b) identifying the patient as having or likely to have aggressive prostate cancer if there is a statistically significant difference in the levels of fucosylated PSA, transmembrane prostate androgen-induced protein, kallikrein-2, lipid phosphate phosphohydrolase 3, heparan-sulfate 6-O-sulfotransferase, PAP, nuclear RNA export factor 2, and protein POF1B as compared to corresponding levels in a control sample that correlates to non-aggressive prostate cancer. | 2016-03-10 |
20160069885 | Detection of Early-Stage Pancreatic Adenocarcinoma - Described herein are compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human PAM4 antibodies. The subject antibodies show a number of novel and useful diagnostic characteristics, such as binding with high specificity to pancreatic and other cancers, but not to normal pancreatic tissues and binding to a high percentage of early stage pancreatic cancers. In preferred embodiments, the antibodies bind to pancreatic cancer mucins. The antibodies and fragments are of use for the detection and diagnosis of early stage pancreatic cancer. In preferred embodiments, the anti-pancreatic cancer antibodies can be used for immunoassay of serum samples, wherein the immunoassay can detect a marker for early stage pancreatic cancer in serum. More preferably, the serum is extracted with an organic phase, such as butanol, before immunoassay. | 2016-03-10 |
20160069886 | BIOMARKERS FOR EARLY DETECTION OF OVARIAN CANCER - Biomarker proteins that can be used in the diagnosis of early-stage ovarian cancer (OC) are described. The biomarker panels not only permit the distinction of patients with ovarian neoplasia (benign or malignant) from normal subjects, but they also allow the identification of patients with early-stage (stage I/II) ovarian cancer from those patients with benign ovarian tumors or normal individuals. The invention additionally provides methods for detecting and treating various cancers, including cancer of the ovary using OC-related molecules. | 2016-03-10 |
20160069887 | BIOMARKERS FOR PROGNOSIS - The invention relates to biomarkers for determining the prognosis of cancer patients. By determining the level of the biomarker HR23B in the cell or patient, and optionally determining the levels of one or more of the biomarkers HDAC6, LC3 and HSP90, the invention provides a method for determining the susceptibility of a cell or a patient of interest to entering an autophagocytic state upon treatment with a drug. The invention also provides a method of determining susceptibility of a cell or patient to treatment with a drug. Entering an autophagocytic state is thought to be a tumour cell survival mechanism, whereby the tumour cell avoids apoptosis. The methods of the invention may therefore be helpful for determining whether a patient should be treated and for determining the prognosis upon drug treatment. | 2016-03-10 |
20160069888 | METHOD FOR THE DIAGNOSTIC OF CANCER AND ENZYME-LINKED IMMUNOASSAY (ELISA) KIT FOR ITS APPLICATION - The invention relates to the field of medical diagnostics, immunology and oncology, in particular to the new tumor markers, useful in the early diagnosis of cancer and methods for cancer diagnostics. A new antigen for ELISA to detect antibodies associated with malignancies, namely, mature human plasminogen or human plasminogen fragments containing kringles. We propose a method of diagnosing cancer at an early stage by detecting autoantibodies of type IgA, IgG, IgM to human plasminogen or its fragments in a samples of human blood plasma or sera. | 2016-03-10 |
20160069889 | COMPOSITIONS AND METHODS FOR APTAMER SCREENING - Methods are provided for selecting aptamers that are specific to a target of interest from amongst a library of potential aptamer sequences. Aptamers disclosed can be used to detect and/or characterize biological entities of interest, e.g. microvesicles and/or surface antigens. Further disclosed are biomarkers that can be used for diagnosing different disorders including different types of cancer. | 2016-03-10 |
20160069890 | MOLECULAR LABELING METHODS - The disclosed methods involve deglycosylating a target molecule to remove target carbohydrates to create vacant glycosylation acceptor sites and then using glycosyltransferases to incorporate replacement carbohydrates into those sites. The methods also involve using glycosytransferases to incorporate new carbohydrates into vacant glycosylation acceptor sites without having to perform in vitro deglycosylation. The replacement or new carbohydrates include a click chemistry moiety that reacts to a click chemistry moiety on a label. | 2016-03-10 |
20160069891 | DIAGNOSTIC BIOMARKER TO IDENTIFY WOMEN AT RISK FOR PRETERM DELIVERY - The invention relates to biomarkers associated with preterm delivery. More specifically, the invention provides methods of measuring biomarkers found in women that are at risk for preterm delivery. | 2016-03-10 |
20160069892 | ANALYSIS OF AMINO ACID COPOLYMER COMPOSITIONS - Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard. | 2016-03-10 |
20160069893 | Methods and Compositions for Analyzing Proteins - Methods, compositions and kits are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone a post-translational modification. A mixture comprising the sample and a first reagent comprising a cleavage-inducing moiety and a first binding agent for a binding site on a target polypeptide is subjected to conditions under which binding of respective binding moieties occurs. The binding site is the result of post-translational modification activity involving the target polypeptide. The method may be employed to determine the target polypeptide itself. In another embodiment the presence and/or amount of the target polypeptide is related to the presence and/or amount and/or activity of an agent such as an enzyme involved in the post-translational modification of the target polypeptide. The interaction between the first binding agent and the binding site brings the cleavage-inducing moiety into close proximity to a cleavable moiety, which is associated with the polypeptide and is susceptible to cleavage only when in proximity to the cleavage-inducing moiety. In this way, an electrophoretic tag for each of the polypeptides may be released. Released electrophoretic tags are separated and the presence and/or amount of the target polypeptides are determined based on the corresponding electrophoretic tags. | 2016-03-10 |
20160069894 | METHODS FOR AFFINITY MATURATION-BASED ANTIBODY OPTIMIZATION - Provided herein is a rational method of affinity maturation to evolve the activity of an antibody or portion thereof based on the structure/affinity or activity relationship of an antibody. The resulting affinity matured antibodies exhibit improved or optimized binding affinity for a target antigen. | 2016-03-10 |
20160069895 | IMMUNOGENIC MUTANT PEPTIDE SCREENING PLATFORM - The present disclosure provides methods of identifying a disease-specific immunogenic peptide through a series of selection steps. Immunogenic epitopes identified by methods of the present disclosure are applicable for use in peptide-based immunotherapy, preferably cancer therapy. Furthermore, the methods of the present disclosure may be performed in a high-throughput manner and serve as a means of personalized vaccine development and therapy. Also provided are compositions of immunogenic peptides as well as methods of treatment comprising said compositions. | 2016-03-10 |
20160069896 | DIAGNOSIS OF AUTOIMMUNE DISEASES USING A SPECIFIC ANTIBODY PROFILE - Methods and kits for diagnosing systemic lupus erythematosus (SLE) or scleroderma in a subject are provided. Particularly, the present invention relates to a specific antibody reactivity profile useful in diagnosing SLE or scleroderma in a subject. | 2016-03-10 |
20160069897 | SELECTION OF FAB FRAGMENTS USING RIBOSOMAL DISPLAY TECHNOLOGY - The invention relates to a method for generating and selecting Fab fragments using ribosomal display and cell-free protein synthesis. The invention also provides a ribosomal display reaction system for generating Fab fragment complexes. The compositions of a Fab fragment complex and a library thereof are also provided. | 2016-03-10 |
20160069898 | Methods for Determining Responsiveness to an Anti-CD47 Agent - Methods and kits are provided for determining whether an individual is responsive to an anti-CD47 agent and for determining whether an individual is maintaining responsiveness to an anti-CD47 agent by assaying biological samples for the level of at least one biomarker in a biological sample. | 2016-03-10 |
20160069899 | Electrophysiological assays using oocytes that express human enac and the use of phenamil to improve the effect of enac enhancers in assays using membrane potential reporting dyes - In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human taste tissue. The present invention further relates to amphibian oocyte-based medium-throughput electrophysiological assays for identifying human ENaC modulators, preferably ENaC enhancers. Compounds that modulate ENaC function in a cell-based ENaC assay are expected to affect salty taste in humans. The assays described herein have advantages over existing cellular expression systems. In the case of mammalian cells, such assays can be run in standard 96 or 384 well culture plates in high-throughput mode with enhanced assay results being achieved by the use of a compound that inhibits ENaC function, preferably an amiloride derivative such as Phenamil. In the case of the inventive oocyte electrophysiological assays (two-electrode voltage-clamp technique), these assays facilitate the identification of compounds which specifically modulate human ENaC. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit hENaC function. Compounds that enhance or block human ENaC channel activity should thereby modulate salty taste in humans. | 2016-03-10 |
20160069900 | IMMUNOASSAY FOR SOLUBLE PD-L1 - The present disclosure describes two matched antibody pairs for use in a sandwich immunoassay for detecting and quantifying soluble PD-L1 in liquid samples, as well as an electrochemiluminescence sandwich immunoassay that has been optimized and validated with one of the matched pairs. | 2016-03-10 |
20160069901 | Methods for Identifying Modulators of Ion Channels - The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels. | 2016-03-10 |
20160069902 | MEASURING CIRCULATING THERAPEUTIC ANTIBODY, ANTIGEN AND ANTIGEN/ANTIBODY COMPLEXES USING ELISA ASSAYS - The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease. | 2016-03-10 |
20160069903 | METHOD FOR DETECTING CELLS - The present invention relates to methods for detecting the chromatin state of a cell based on recording a super resolution image of nucleosome organization and correlating said imaged with size of nucleosomal clutches, nucleosomal density and/or number of nucleosomes per nucleosomal clutches. Additionally, the invention relates to a kit comprising a first antibody capable of specifically binding to a histone protein and a photo switchable fluorophore linked-secondary antibody and the use of the kit of the invention for detecting the chromatin state of a cell and isolating a cell in an open chromatin state or in a close chromatin state. The invention also relates to a device adapted to detect the chromatin state of a cell. | 2016-03-10 |
20160069904 | Methods for Early Diagnosis of Kidney Disease - The invention provides reagents and methods for diagnosing kidney disease in a human or animal. | 2016-03-10 |
20160069905 | Compositions and Methods for Detection of Defensins in a Patient Sample - Methods, devices and compositions for diagnosing, predicting and monitoring a urinary tract infection in a subject are described. The detection, prediction and monitoring of a urinary tract infection in a subject by detection of HD5 in the urine of a subject is described. | 2016-03-10 |