11th week of 2013 patent applcation highlights part 45 |
Patent application number | Title | Published |
20130065765 | DEGRADABLE SUPERABSORBENT POLYMERS - The present disclosure relates to degradable superabsorbent materials based on acetals of glyoxylic acid and derivatives thereof with polyvinyl alcohol, and methods of making the polymers. The polymers are used to make superabsorbent particles, coatings, sheets, and fibers. Formulations and articles including the superabsorbent polymers, particles, coatings, sheets, and fibers are also disclosed. | 2013-03-14 |
20130065766 | ELECTRICITY TRANSMISSION COOLING SYSTEM - A cooling system includes a first section of high temperature superconducting (HTS) cable configured to receive a first flow of coolant and to permit the first flow of coolant to flow therethrough. The system may further include a second section of high temperature superconducting (HTS) cable configured to receive a second flow of coolant and to permit the second flow of coolant to flow therethrough. The system may further include a cable joint configured to couple the first section of HTS cable and the second section of HTS cable. The cable joint may be in fluid communication with at least one refrigeration module and may include at least one conduit configured to permit a third flow of coolant between said cable joint and said at least one refrigeration module through a coolant line separate from said first and second sections of HTS cable. | 2013-03-14 |
20130065767 | Method for manufacturing a magnet coil configuration using a slit band-shaped conductor - A magnet coil configuration ( | 2013-03-14 |
20130065768 | RANDOM ARRAY SEQUENCING OF LOW-COMPLEXITY LIBRARIES - The invention is directed to a method of sequencing low-complexity amplicons randomly arrayed at high density on a surface. Methods of the invention include preparing amplicons for sequencing by a sets of primers that ensure initial signals front different amplicons on the surface will be evenly distributed among the different nucleotides being added in a sequencing by synthesis operation. | 2013-03-14 |
20130065769 | SALIVARY BIOMARKERS FOR GASTRIC CANCER DETECTION - Disclosed herein are biomarkers related to gastric cancer. The presently identified salivary biomarkers create the basis for a gastric cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed gastric cancer assay in clinical, diagnostic and therapeutic uses is also included. | 2013-03-14 |
20130065770 | Methods and Compositions for Tagging and Identifying Polynucleotides - The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the oligonucleotide tags of polynucleotides selected in such assays. Words, or subunits, of oligonucleotide tags index submixtures in successively more complex sets of submixtures (referred to herein as “tiers” of submixtures) that a polynucleotide goes through while successive words are added to a growing tag. By identifying each word of an oligonucleotide tag, a series of submixtures is identified including the first submixture that contains only a single polynucleotide, thereby providing the identity of the selected polynucleotide. The analysis of the words of an oligonucleotide tag can be carried out in parallel, e.g. by specific hybridization of the oligonucleotide tag to its tag complement on an addressable array; or such analysis can be carried out serially by successive specific hybridizations of labeled word complements, or the like. | 2013-03-14 |
20130065771 | Apparatus and method for parallel collection and analysis of the proteome and complex compositions - This invention relates to a kit and a method for the collection and analysis of complex protein mixtures. More particularly, the invention relates to a kit comprising a single barrel filtration well or a multi-well filtration plate wherein each well comprises an upper filtration zone; a lower filtration zone; a conical flow director zone; and, an elution tip, wherein the upper filtration zone and the lower filtration zone are separated by a retainer ring disposed within the lower filtration zone. The upper filtration zone comprises an upper collection zone, a sponge zone, and a deep bed filtration zone; and, the lower filtration zone comprises the retainer ring, a supported hydrophilic membrane and a lower bed filtration media. When used with an array of selected buffer solutions, the multi-well filtration plate can provide accurate, automated, high-throughput protein analysis by affinity chromatography. | 2013-03-14 |
20130065772 | PROGNOSTIC MOLECULAR SIGNATURE OF SARCOMAS, AND USES THEREOF - Described herein are methods and compositions that can be used for diagnosis and treatment of soft tissue sarcoma cancer phenotypes and soft tissue sarcoma cancer-associated diseases. Also described herein are methods that can be used to identify modulators of soft tissue sarcoma cancer. | 2013-03-14 |
20130065773 | Microfluidic Device and Methods of Using Same - A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses. | 2013-03-14 |
20130065774 | DNA RECOMBINATION JUNCTION DETECTION - The present invention provides methods, compositions and kits for detecting the presence or absence of an integrated insertion polynucleotide. | 2013-03-14 |
20130065775 | Methods for diagnosing skin diseases - The present invention relates to methods for diagnosing cornification disorders and metabolic diseases. More specifically, the present invention relates to an in vitro method for diagnosing and/or predicting a cornification disorder in a subject, comprising determining the presence or the absence of a genetic variation in the Patatin-like phospholipase domain-containing protein 1 (PNPLA1) gene sequence in a biological sample from said subject, as compared with the PNPLA1 gene sequence of a healthy non-carrier subject, wherein the presence of said genetic variation indicates that said subject suffers from or is at risk of suffering from said cornification disorder. The method according to the invention allows for example diagnosing ichthyosis in dogs of the Golden Retriever breed. | 2013-03-14 |
20130065776 | SELECTIVE ENRICHMENT OF NON-METHYLATED NUCLEIC ACIDS - The present invention relates to a method for selectively amplifying non-methylated sequences of a DNA comprising the steps of (i) providing a sample comprising a DNA which is methylated at least one site, (ii) treating the DNA in the sample with a methylation-dependent nuclease, and (iii) amplifying the DNA cut using the methylation-dependent nuclease. In addition, the invention relates to kits for use in the method according to the invention. The method according to the invention can be used for selectively preparing to (selectively accumulating) non-methylated sequence segments of genomic DNA and for analysing the global methylation pattern in genomic DNA. | 2013-03-14 |
20130065777 | NANOSTRUCTURE BIOSENSORS AND SYSTEMS AND METHODS OF USE THEREOF - A sensor scheme combining nano-photonics and nano-fluidics on a single platform through the use of free-standing photonic crystals is described. By harnessing nano-scale openings, both fluidics and light can be manipulated at sub-wavelength scales. The convective flow is actively steered through the nanohole openings for effective delivery of the analytes to the sensor surface, and refractive index changes are detected in aqueous solutions. Systems and methods using cross-polarization measurements to further improve the detection limit by increasing the signal-to-noise ratio are also described. | 2013-03-14 |
20130065778 | MicroRNA Signatures Predicting Responsiveness To Anti-HER2 Therapy - The invention provides miRNA signatures and methods of making and using thereof. MiRNA signatures determine the responsiveness of HER2 expressing breast tumors to anti-HER2 treatment, such as the targeted drug therapy trastuzumab. | 2013-03-14 |
20130065779 | METHOD AND REAGENT FOR DIAGNOSIS AND/OR EVALUATION OF PROGRESSION OF GRAFT-VERSUS-HOST DISEASE - Disclosed is a method of diagnosing graft-versus-host disease, comprising measuring the level of CCL8 protein in a sample obtained from a subject as an indicator for the diagnosis or course of graft-versus-host disease. Also a diagnostic reagent for graft-versus-host disease comprising an anti-CCL8 antibody is disclosed. The method of the present invention enables diagnosis of the onset of graft-versus-host disease and monitoring of the progress, in particular, differential diagnosis between graft-versus-host disease and an infectious disease. The present invention also provides a method for treating graft-versus-host disease utilizing the anti-CCL8 antibody. | 2013-03-14 |
20130065780 | Label-Free Multiplexing Bioassays Using Fluorescent Conjugated Polymers and Barcoded Nanoparticles - Label-free, multiplexed DNA assay using fluorescent conjugated polymers as a detection probe to illustrate hybridization on metallic striped nanorods are disclosed. Different DNA capture probes are encoded by the different reflectivity of Au and Ag stripe patterns. The integration of fluorescent conjugated polymers as detection moieties with metallic striped nanorods for multiplexed detection of clinically important cancer marker proteins in an immunoassay format is also provided. | 2013-03-14 |
20130065781 | GENE SETS FOR DETECTION OF ULTRAVIOLET A EXPOSURE AND METHODS OF USE THEREOF - Ultraviolet radiation (UVR) has profound effects on human skin. However, its effects on the global transcriptome in vivo have not been well characterized. In addition, the contribution of the UVA component of UVR has not been previously assessed in vivo. Disclosed herein is the identification of sets of genes that are either up-regulated or down-regulated in response to UVA exposure. The gene sets described herein can be used to accurately identify skin samples that have been exposed to UVA and to assess the ability of a sun protection product to block the effects of UVA. | 2013-03-14 |
20130065782 | Renal Cell Carcinoma Biomarkers and Uses Thereof - The subject disclosure concerns methods for evaluation of renal cell carcinoma (RCC). Such methods include a method of determining of a diagnosis of the individual as having or not having RCC; determination of a prognosis of a future course of RCC; determination of disease burden; or determination of recurrence of RCC in an individual who had been apparently cured of RCC. The methods each involve the detection of the value of at least one biomarker of Table 1. The biomarker value is used, in some of the methods, to determine whether the individual does or does not demonstrate evidence of disease, and in another method, to determine the degree or a score indicative of the individual's extent of disease. | 2013-03-14 |
20130065783 | MICROARRAYS BASED ON ENZYME-MEDIATED SELF-ASSEMBLY - Provided herein are systems and related methods comprising (i) short stretches (e.g., 9 to 24 bases) of single-stranded nucleic acid (e.g., DNA) capture probes coated with RecA and, in some instances, bound to a solid substrate, and (ii) double-stranded nucleic acid (e.g., DNA or RNA) target(s). | 2013-03-14 |
20130065784 | MULTIPHASE MICROARRAYS AND USES THEREOF - The present invention relates to solution microarrays. In particular, the present invention relates to an aqueous 2-phase system for solution microarrays and uses thereof. Additional embodiments are described herein. | 2013-03-14 |
20130065785 | PROGNOSIS OF OESOPHAGEAL AND GASTRO-OESOPHAGEAL JUNCTIONAL CANCER - The present invention relates to a method of aiding in the prognosis of a subject with oesophageal and/or gastro-oesophageal junctional (GOJ) adenocarcinoma, the method comprising the steps of: (a) providing a sample from the subject, (b) determining the expression level of biomarkers TRIM44 and SIRT2 in said sample, and either (i) determining the expression level of biomarker PAPPS2 in said sample; or (ii) determining the expression level of biomarkers WT1 and EGFR in said sample; (c) comparing the expression level of each of said biomarkers to a corresponding reference standard, (d) determining the biomarkers of (b) whose expression is dysregulated compared to the reference standard, (e) inferring from the dysregulated biomarkers identified in (d) the prognosis of 5-year survival, wherein the greater the number of said biomarkers which are dysregulated, the greater the reduction in prognosis of 5-year survival. The invention also relates to kits, uses and devices. | 2013-03-14 |
20130065786 | METHOD FOR BREAST CANCER RECURRENCE PREDICTION UNDER ENDOCRINE TREATMENT - The present invention relates to methods, kits and systems for the prognosis of the disease outcome of breast cancer, said method comprising:
| 2013-03-14 |
20130065787 | REAL TIME PCR ASSAY FOR DETECTION OF BACTERIAL RESPIRATORY PATHOGENS - Methods for detecting | 2013-03-14 |
20130065788 | ASSAY MODULES HAVING ASSAY REAGENTS AND METHODS OF MAKING AND USING SAME - We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state. | 2013-03-14 |
20130065789 | COMPOSITIONS AND METHODS FOR CLASSIFYING LUNG CANCER AND PROGNOSING LUNG CANCER SURVIVAL - The application provides methods of prognosmg, diagnosing, screening and classifying lung cancer patients into poor survival groups or good survival groups. A number of altered genomic regions have been identified that distinguish subtype of lung adenocarcinoma (ADC), specifically between bronchioloalveolar carcinoma (BAC) and invasive ADC with BAC features (AWBF), and genes and biomarkers whose expression are altered in individuals with pulmonary ADC according to different survival outcomes. The amplification and/or deletion of these genomic regions, and/or the biomarker expression profiles can be used to classify patients with ADC into a BAC group with excellent survival outcome, or an invasive ADC with BAC features group with higher risk of developing metastatic recurrence and poorer survival outcome. The application also includes kits for use in the methods of the application. | 2013-03-14 |
20130065790 | ASSAYS, COMPOSITIONS AND METHODS FOR DETECTING DRUG RESISTANT MICRO-ORGANISMS - The present invention relates to assays, compositions and methods for the detection and discrimination of specific gene sequences encoding antibiotic resistance in a sample. The nucleotide sequences encoding antibiotic resistance genes are uniquely identified. In particular, these sequences are hybridized to capture probes, enabling real-time PCR. For this purpose, the capture probes may also be covalently linked to amplification primers. Alternatively, detection of amplified products with hybridization to capture probes may be performed after amplification by hybridization to capture probes bound to a solid support such as microarrays and microspheres (beads). Finally, detection of amplification products during amplification in real-time using capture probes may be combined with detection of such amplification products after amplification using the same and/or different capture probes. | 2013-03-14 |
20130065791 | METHODS AND KITS FOR DIAGNOSING COLORECTAL CANCER - The invention pertains to a method for early detection and screening of colorectal cancer in human subjects based on RNA isolated from blood obtained from said subject. According to the invention, the abundance of at least 3, 5, 8, 30, 60, 102, 202, 55, 1002 or 1002 RNAs listed in tables 1 to 13 is measured. Using the invention, an accurate and noninvasive screening and diagnosis tool for colorectal cancer is provided with a sensitivity of at least 80% and a specificity of 85% that has high clinical utility and the potential for broad adoption. | 2013-03-14 |
20130065792 | INDUCIBLE EXPRESSION OF SGLT5, METHODS AND KITS USING THE SAME - The present invention pertains to the function of SGLT5 as a sodium dependent co-transporter of mannose and/or fructose. The invention provides nucleic acids and host cells for inducible expression of SGLT5. Based on an inducible expression system the invention provides methods, assays and test kits for the identification of compounds interacting with SGLT5, especially with human SGLT5. | 2013-03-14 |
20130065793 | Methods and Compositions for Tagging and Identifying Polynucleotides - The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the oligonucleotide tags of polynucleotides selected in such assays. Words, or subunits, of oligonucleotide tags index submixtures in successively more complex sets of submixtures (referred to herein as “tiers” of submixtures) that a polynucleotide goes through while successive words are added to a growing tag. By identifying each word of an oligonucleotide tag, a series of submixtures is identified including the first submixture that contains only a single polynucleotide, thereby providing the identity of the selected polynucleotide. The analysis of the words of an oligonucleotide tag can be carried out in parallel, e.g. by specific hybridization of the oligonucleotide tag to its tag complement on an addressable array; or such analysis can be carried out serially by successive specific hybridizations of labeled word complements, or the like. | 2013-03-14 |
20130065794 | PROCESS FOR MAKING AN ARRAY - There is disclosed a method of making an array for cell assays comprising the step of providing an array of structures on a substrate, each of said structures having a pre-defined topography thereon, and wherein at least one structure has a different topography from at least one other structure. | 2013-03-14 |
20130065795 | ARRAY OF MICROMOLDED STRUCTURES FOR SORTING ADHERENT CELLS - An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe). | 2013-03-14 |
20130065796 | Advanced Mixing System for Integrated Tool Having Site-Isolated Reactors - An integrated processing tool is described comprising a full-wafer processing module and a combinatorial processing module. Chemicals for use in the combinatorial processing module are fed from a delivery system including a set of first manifolds. An output of each first manifold is coupled to at least one mixing vessel. An output of each mixing vessel feeds more than one of a set of second manifolds. An output of each set of second manifolds feeds one of multiple site-isolated reactors of the combinatorial processing module. | 2013-03-14 |
20130065797 | AUTOMATED SAMPLE HANDLING INSTRUMENTATION, SYSTEMS, PROCESSES, AND METHODS - The present invention provides a processing station for automatically processing a biological sample, a system for automated real-time inventory control of consumables within a biological sample handling or assay instrument, a high throughput random access automated instrument for processing biological samples, an automated instrument for processing or analysis of a sample, and processes for automated mucoid detection and elimination. Methods of using the disclosed instruments, mucoid detection processes, and systems to process and/or analyze samples are also disclosed. | 2013-03-14 |
20130065798 | WATER-BASED DRILLING FLUID COMPOSITION HAVING A MULTIFUNCTIONAL MUD ADDITIVE FOR REDUCING FLUID LOSS DURING DRILLING - Embodiments of the invention provide a drilling, drill-in, and completion water-based mud composition containing micro or nanoparticles for use in hydrocarbon drilling. The water-based drilling mud composition includes water present in an amount sufficient to maintain flowability of the water-based drilling mud composition, and drilling mud, which includes particles. The particles are selected from microparticles, nanoparticles, and combinations thereof. The water-based drilling mud composition also includes an effective amount of a multi-functional mud additive, which includes psyllium seed husk powder. The water-based drilling mud composition is operable to keep the particles stabilized and dispersed throughout the drilling mud composition in the absence of a surfactant. | 2013-03-14 |
20130065799 | Additives For Inhibition Of Gas Hydrate Formation - The invention provides for the use of copolymers comprising 1 to 99 mol % of structural units of the formula (1) | 2013-03-14 |
20130065800 | COATED AND CURED PROPPANTS - Solid proppants are coated with a coating that exhibits the handling characteristics of a pre-cured coating while also exhibiting the ability to form particle-to-particle bonds at the elevated temperatures and pressures within a wellbore. The coating includes a substantially homogeneous mixture of (i) at least one isocyanate component having at least 2 isocyanate groups, and (ii) a curing agent comprising a monofunctional alcohol, amine or amide. The coating process can be performed with short cycle times, e.g., less than about 4 minutes, and still produce a dry, free-flowing, coated proppant that exhibits low dust characteristics during pneumatic handling but also proppant consolidation downhole for reduced washout and good conductivity. Such proppants also form good unconfined compressive strength without use of an bond activator, are substantially unaffected in bond formation characteristics under downhole conditions despite prior heat exposure, and are resistant to leaching with hot water. | 2013-03-14 |
20130065801 | COMPONENT WITH A SLIDING SURFACE FOR BEARING ANOTHER COMPONENT, AND METHOD FOR PRODUCING A SLIDING LAYER - Particles, embedded into a sliding layer, have a coating, within which a lubricant, e.g., a liquid, is contained. A component with the sliding layer provides a sliding surface that can be used as a backup bearing to ensure emergency operating properties, for example, of a shaft that is mounted in a main bearing. When the shaft strikes the bearing surface, the coating of the particles that are exposed on the bearing surface are destroyed and the lubricant can exit. Advantageously, the sliding properties of the sliding surface are thereby improved. | 2013-03-14 |
20130065802 | TRANSMISSION OIL COMPOSITION FOR PUSH BELT CONTINUOUSLY VARIABLE TRANSMISSION - Disclosed is a transmission oil composition for use in a push belt continuously variable transmission (CVT). The push belt CVT oil composition includes a hydrogenated base oil or a synthetic base oil admixed with a viscosity control agent, a dispersing agent, a friction control agent and other additives at specific ratios and provides improved friction characteristics, durability, thermal stability, oxidation stability and transmission performance. It can be used at various temperature ranges and can provide improved transmission efficiency (fuel efficiency). | 2013-03-14 |
20130065803 | BLOWN AND STRIPPED BLEND OF SOYBEAN OIL AND CORN STILLAGE OIL - A method for producing a high viscosity, low volatiles blown stripped oil blend is provided. The method may include the steps of: (i) obtaining an oil blend of corn stillage oil and soybean oil having a weight ratio of corn stillage oil to soybean oil of from about 1:2 to 3:1; (ii) heating the oil blend to at least 90° C.; (iii) passing air through the heated oil blend to produce a blown oil having a viscosity of at least 50 cSt at 40° C.; and (iv) stripping the blown oil from step (iii) to reduce an acid value of the blown oil to less than 5.0 mg KOH/gram. | 2013-03-14 |
20130065804 | OIL COMPOSITION, AND TRACE AMOUNT OIL SUPPLY TYPE CUTTING/GRINDING PROCESSING METHOD - The present invention provides an oil composition comprising a lubricating base oil, and an alkylene oxide adduct of a hydroxy acid having a hydrophile-lipophile index of 8 to 15, wherein the oil composition is used for cutting/grinding processing by minimal quantity lubrication system. Further, the present invention provides a cutting/grinding processing method by minimal quantity lubrication system, comprising a step of supplying the oil composition of the present invention in the form of mist together with a compressed fluid to processing sites of a workpiece. | 2013-03-14 |
20130065805 | Food Grade Compressor Lubricant - The invention relates to an improved food-grade-lubricant useful as hydraulic oil, circulating oil, drip oil, general purpose oil, grease base oil, cable oil, chain oil, spindle oil, gear oil, and compressor oil for equipment in the food service industry. Specifically, it relates to a composition comprising at least one polyalphaolefin base fluid, at least one food grade polyolester base fluid, and at least one food grade performance additive. | 2013-03-14 |
20130065806 | PREPARATION OF NITRONES - A method for producing a nitrone of formula (I) | 2013-03-14 |
20130065807 | FRAGRANCE SUBSTANCE MIXTURES CONTAINING CERTAIN ISOLONGIFOLENYL METHYL ETHERS - The present invention primarily relates to fragrance substance mixtures, preferably perfume oils, comprising
| 2013-03-14 |
20130065808 | BIODEGRADABLE PERSONAL CLEANSING COMPOSITIONS AND METHODS RELATING TO SAME - A personal cleansing composition includes a surfactant, a thickener, emulsifier and at least one particulate dispersed in the thickener, the at least one particulate being formed of a substantially biodegradable substance. The at least one particulare may include a soy meal based polymer. The soy meal based polymer is both stable and biodegradable. The at least one particulate includes a group of suspended particles added to mechanically scrub the skin of a user or used as a textural ingredient to modify the feel, spreadability or slip of a product. The soy meal based polymer is useful in personal cleansing compositions as an exfoliant, a scrub, a film former or as a filler. The half-life of the composition may be modified as necessary based on the shelf-life of the product. | 2013-03-14 |
20130065809 | STRIPPING COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME - Provided are compositions suitable for stripping coatings from a surface. The compositions may include a solvent and an organic functional amine. The solvent may be benzyl alcohol. The compositions may further include at least one surfactant. The compositions may include at least two surfactants present in the composition at a ratio of about 1:1 to each other. Also provided are methods of stripping a coating from a surface, the method including applying to the surface a composition according to the invention. | 2013-03-14 |
20130065810 | Novel Fungal Protease and Use Thereof - The present invention is related to a fungal serine protease enzyme, which comprises an amino acid sequence of the mature Fe_RF6318 enzyme having an amino acid sequence of SEQ ID NO: 15. The serine protease is obtainable from | 2013-03-14 |
20130065811 | STABLE WATER-SOLUBLE UNIT DOSE ARTICLE - The need for a means to formulate fluid compositions for use in water-soluble unit dose articles having higher levels of water is met by incorporating a di-amido gellant into the fluid composition. The di-amido gellant also simplifies the addition of ingredients to water-soluble unit dose articles, such as microcapsules, that are typically added as aqueous suspensions or slurries. | 2013-03-14 |
20130065812 | WATER-DILUTABLE SOLID CONCENTRATE - A solid composition for cleaning or fragrancing includes at least one ethoxylated alcohol, at least one C12-C24 saturated fatty acid sodium salt, water, at least one glycol, and at least one water insoluble component. The solid composition can have a weight ratio of water to glycol to C12-C24 saturated fatty acid sodium salt between about 2:2.5:1 and about 3:4:1. | 2013-03-14 |
20130065813 | FLUID FABRIC ENHANCER COMPOSITIONS - Fluid fabric enhancer compositions comprising external structurants and processes for making and using same are provided. Such fluid fabric enhancer compositions can have a rich impression, stabilize/suspend performance ingredients such as perfume microcapsules, be easily poured/dosed and minimizes residue build up in laundry machine dispensers. In addition, such compositions have tunable rheologies. | 2013-03-14 |
20130065814 | INDUCTIVE PRODUCTION OF PLURIPOTENT STEM CELLS USING SYNTHETIC TRANSCRIPTION FACTORS - The present invention relates to use of synthetic factors in reprogramming somatic cells to become induced pluripotent stem cells and other cell lineages. Specifically, the present application relates to fusion proteins containing proteins encoded by cell totipotency-related genes and transcription regulatory domains, their coding sequences, expression vectors, and compositions. The present application also relates to methods for reprogramming somatic cells to become induced pluripotent stem cells and other cell lineages, and cells containing the fusion proteins or the coding sequences. | 2013-03-14 |
20130065815 | Fn 14/TRAIL Fusion Proteins - Fusion proteins which act on the TWEAK and TRAIL signaling axes are provided. The proteins are useful in the treatment or amelioration of autoimmune diseases, particularly multiple sclerosis, as well as other diseases such as alloimmune diseases and cancer. | 2013-03-14 |
20130065816 | ANALOGS OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND METHODS FOR THEIR USE - This invention relates to novel analogs of pituitary adenylate cyclase-activating polypeptide (PACAP), which are agonists for the PACAP/vasoactive intestinal peptide (VIP) receptors: PAC1, VPAC1 and VPAC2 receptors. These PACAP analogs can be used as prophylactic/therapeutic agents for a wide range of medical disorders, including (but not limited to) cancer and autoimmune disease. These PACAP analogs can be coupled to suitable radionuclides and used in the localization, diagnosis and treatment of disseminated cancers and metastatic tumors, or coupled to small molecule therapeutics and used as vectors for targeted drug delivery. This invention also provides pharmaceutical compositions of one or more PACAP-like compounds of the invention either alone or in combination with one or more other prophylactic/therapeutic agents. | 2013-03-14 |
20130065817 | POLYPEPTIDE ACTING TO ENHANCE ISCHEMIC DISEASES - Disclosed is a polypeptide of use in the development of reagents or medicines favourable to application for prevention or treatment of ischemic disorders such as conditions caused by ateriosclerosis. The polypeptide has at least one part containing an amino acid of sequence ID 1, and also enhances expression levels of the amino acid in mammalian blood vessels removed from ischemic conditions by means of blood reperfusion. | 2013-03-14 |
20130065818 | Arylamide Compounds And Compositions And Uses Thereof - The present invention discloses ophthalmic and otic compositions of facially amphiphilic antimicrobial polymers and oligomers and their uses, including their use in methods for treating and preventing ophthalmic infections and otic infections in humans and animals. | 2013-03-14 |
20130065819 | TARGET OF EGR1 (TOE1) POLYPEPTIDES FOR INHIBITION OF HIV - Described are methods and compositions for preventing and/or treating HIV infection, as well as in vitro and in vivo methods of inhibiting HIV replication, inhibiting HIV viral transcription, inhibiting the viral Tat protein, and inhibiting HIV LTR expression. The methods involve administering a Target of Egr1 (TOE1) polypeptide, fragment or deletion mutant thereof, either to a subject in need of treatment or to a cell infected with an HIV virus. Compositions may comprise the described polypeptide, or an encoding polynucleotide thereof. | 2013-03-14 |
20130065820 | SYNTHETIC MYOSTATIN PEPTIDE ANTAGONISTS - The present invention relates to novel synthetic myostatin antagonists, comprising a synthetic mature myostatin peptide, wherein the peptide comprises at least two cysteine residues at positions | 2013-03-14 |
20130065821 | COMPOSITION FOR PREVENTING AND IMPROVING METABOLIC SYNDROME - A method for improving blood HDL/LDL cholesterol ratio, reducing blood triglyceride level, reducing blood sugar level, and/or reducing body weight, that includes ingesting a composition containing a concentrated soybean germ product. The soybean germ product includes soybean germ protein; 1.0% by weight or less of saponin relative to the total weight of the soybean germ product; and 0.5% by weight or less of isoflavone relative to the total weight of the soybean germ product. | 2013-03-14 |
20130065822 | COMPOSITIONS FOR MASKING THE FLAVOR OF NUTRIENTS AND METHODS FOR MAKING SAME - Nutritional compositions and methods of making and using the nutritional compositions are provided. In a general embodiment, the present disclosure provides nutritional compositions having whey protein micelles and leucine. The nutritional compositions provide a sufficient amount of leucine to improve protein synthesis in humans, while also maintaining a low-viscosity fluid matrix and acceptable organoleptic properties. | 2013-03-14 |
20130065823 | Supplement for Strengthening the Muscles of a Human - A protein and amino acid supplement for strengthening the muscles of a human, the supplement comprises of: a Creatine monohydrate; a vitamic C; a hydrolyzed collagen; and a hydrolyzed casein. The supplement may further comprise of L-glutamine, ribose, taurine, alpha lipoic acid, methyl sulfonyl methane. The supplement may further comprise of glucosamine sulfate and chondroitin sulfate. | 2013-03-14 |
20130065824 | CONTROLLING THE TEXTURE OF HIGH-PROTEIN NUTRITIONAL COMPOSITIONS COMPRISING MICELLAR CASEIN - Medical dairy products are highly concentrated in proteins and minerals. Formulation of such products is challenging, since viscosities can easily increase during processing and storage. It was found that using one or more chelating agents selected from the group consisting of a phosphoric acid, citric acid, a soluble phosphate salt, a soluble citrate salt, or a mixture thereof, the viscosity and the transparency of an aqueous micellar casein composition, comprising 6 to 20 g/100 ml of micellar casein and having a pH of about 6 to 8 could be controlled independently of each other. It was found that products become more viscous after addition of phytate, citrate, or orthophosphate, and that the viscosity depends on concentration and type of phosphate. Addition of hexametaphosphate leads to gel formation. In contrast, high concentrations of uridine monophosphate can be added without significantly affecting the viscosity. | 2013-03-14 |
20130065825 | Compositions and Methods for Delaying Senescence or Cell Death in Neurons - The described invention provides methods and compositions for enhancing the enzymatic activity of Sirtuin family members by using Leptin, Leptin analogs, Leptin derivatives, or Leptin agonists. The described invention further provides compositions and methods for delaying senescence or cell death in neurons using the compositions. | 2013-03-14 |
20130065826 | Injectable solution at pH 7 Comprising at least one basal insulin whose PI is between 5.8 and 8.5 - A composition in the form of an injectable aqueous solution, the pH of which is between 6.0 and 8.0, includes at least a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5; and a dextran substituted by radicals carrying carboxylate charges and hydrophobic radicals. Single-dose formulations at a pH of between 7 and 7.8 includes a basal insulin whose isoelectric point is between 5.8 and 8.5 and a prandial insulin. | 2013-03-14 |
20130065827 | Crystalline Peptide Epoxyketone Immunoproteasome Inhibitor - The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. | 2013-03-14 |
20130065828 | PHARMACEUTICAL COMBINATION FOR USE IN GLYCEMIC CONTROL IN DIABETES TYPE 2 PATIENTS - The present invention refers to a pharmaceutical combination for use in glycemic control in diabetes type 2 patients. | 2013-03-14 |
20130065829 | PEPTIDES AND SUPPORTED PEPTIDES FOR TREATING SKIN DISEASES - The present invention provides peptides and supported peptides for treating proliferative diseases. In particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein is BBI. | 2013-03-14 |
20130065830 | Dopamine Neuron Stimulating Peptide-11 Protection From Complex 1 Mitochondrial Inhibitors - The present invention relates to the use of novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (GDNF) peptides (or “Amidated Dopamine Neuron Stimulating peptides (ADNS peptides)”), for treating brain diseases and injuries that result in dopaminergic deficiencies and mitochodrial dysfunction, e.g., reduced complex I enzyme activity. | 2013-03-14 |
20130065831 | METHOD FOR THE PRODUCTION OF CONJUGATES OF INSULIN-LIKE GROWTH FACTOR-1 AND POLY(ETHYLENE GLYCOL) - The present invention relates to a fusion protein comprising IGF-I or an IGF-I variant N-terminally linked to the C-terminus of a propeptide. The invention relates also to a method involving the use of the aforementioned fusion protein in the production of a lysine-PEGylated IGF-I or IGF-I variant. The method comprises the steps of cultivating a prokaryotic host cell comprising an expression vector containing a nucleic acid encoding the fusion protein and causing the cell to express the fusion protein, recovering and PEGylating said fusion protein, cleaving said PEGylated fusion protein with IgA protease, and recovering lysine-PEGylated IGF-I or IGF-I variant. The invention relates also to a lysine-PEGylated IGF-I or IGF-I variant produced using the above method. In addition, the invention relates to a method for treating a neurodegenerative disorders like Alzheimer's Disease using the lysine-PEGylated IGF-I or IGF-I variant and a composition comprising the lysine-PEGylated IGF-I or IGF-I variant. | 2013-03-14 |
20130065833 | ALKYLATED SP-B PEPTOID COMPOUNDS AND RELATED LUNG SURFACTANT COMPOSITIONS - SP-B peptoid compounds, lung surfactant compositions and related surfactant replacement therapies. Such SP-B peptoids can mimic lung surfactant protein B, and can be used in conjunction with biomimetic SP-C compounds over a range of lung surfactant compositions. | 2013-03-14 |
20130065834 | MODULATORS OF PROTEASOME ACTIVITY - Methods of modulating proteasome activity, increasing life span and neurogenesis are provided herein. | 2013-03-14 |
20130065835 | PROGNOSTIC TESTS FOR DEVELOPMENT OF DERMAL STRETCH MARKS AND IMPLICATIONS FOR THE PREVENTATIVE TREATMENT THEREOF - Various methods of assessing the regenerative potential of dermal tissue in a patient may be determined and methods to determine the potential development of stretch marks in a patient are provided. Through the analysis of a series of dermal tissue samples, a method of monitoring the aging process of the dermal tissue of a patient is possible. Damaged or stretched marked skin may also be used in the development of various diagnostic therapies relating to the inducement of the extracellular matrix components of the skin due to the loss of elastic fibers generally found in stretch marked skin. | 2013-03-14 |
20130065836 | BIOMARKER FOR GASTRIC CANCER - The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the BCL6B gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing BCL6B gene expression or activity. | 2013-03-14 |
20130065837 | INTEGRIN INTERACTION INHIBITORS FOR THE TREATMENT OF CANCER - Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interact with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etoposide. | 2013-03-14 |
20130065838 | SAP VARIANTS AND THEIR USE - Polypeptides are susceptible to denaturation or enzymatic degradation in the blood, liver or kidney. Due to the low stability of some polypeptides, it has been required to administer polypeptide drugs in a sustained frequency to a subject in order to maintain an effective plasma concentration of the active substance. Furthermore, pharmaceutical compositions of therapeutic peptides preferably have a shelf-life of several years in order to be suitable for common use. However, peptide compositions are inherently unstable due to sensitivity towards chemical and physical degradation. In part, the invention provides SAP variant proteins, compositions, pharmaceutical preparations and formulations having a prolonged in vivo half-life, prolonged shelf-life, or rather increased in vitro stability, or increased manufacturing efficiency compared to human SAP. Advantages of increased plasma half-life include, but are not limited to, reducing the amount and/or frequency of dosing. | 2013-03-14 |
20130065839 | TREATMENT OF T-CELL MEDIATED DISEASES - The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions. | 2013-03-14 |
20130065840 | METHOD AND PEPTIDE FOR REGULATING CELLULAR ACTIVITY - Method and peptide for regulating cellular activity includes a panel of synthesized peptides that have biological effects on inhibiting or enhancing cellular activity. Selected peptides can be used as therapy to reduce and/or inhibit, or initiate and/or enhance, an inflammatory response in a subject. | 2013-03-14 |
20130065841 | PROCESS FOR A FOLATE-TARGETED AGENT - The invention described herein pertains to an improved process for preparing the folate-targeted conjugate EC 145 and to the conjugate EC 145 prepared using the improved process, as well as to a pharmaceutical composition comprising the conjugate EC 145 prepared using the improved process. | 2013-03-14 |
20130065842 | COMPOUNDS AS RORyT MODULATORS AND USES THEREOF - Heterocyclic compounds, and pharmaceutical compositions thereof, are disclosed as RORγt modulators that have a formula represented by the following: | 2013-03-14 |
20130065843 | Phenolic Compositions Derived From Apple Skin And Uses Thereof - Described herein are phenolic compositions derived from apple skins. In particular, described herein are flavonoid-rich fractions derived from apple skin extract. The compositions are useful in the prevention and treatment of conditions associated with oxidative stress and/or inflammation, including certain neurodegenerative diseases. Methods of producing the compositions are also described. | 2013-03-14 |
20130065844 | Compositions of Stable Tiacumicins - The present invention is related to pharmaceutical compositions of one or more tiacumicins that exhibit improved stability, and methods of treatment using such formulations. The formulations contain one or more tiacumicins, such as difimicin, and one or more antioxidants, such as butylated hydroxytoluene, and, optionally, one or more pharmaceutically acceptable excipients. | 2013-03-14 |
20130065845 | Triazole Compounds and Methods of Making and Using the Same - The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. | 2013-03-14 |
20130065846 | PARASITICIDAL COMPOSITIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES THEREOF - This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof. | 2013-03-14 |
20130065847 | ENDOPARASITICIDAL COMPOSITIONS - The invention relates to a synergistic composition for controlling endoparasites in and on animals, which comprises a combination of
| 2013-03-14 |
20130065848 | LEVOISOVALERYLSPIRAMYCIN I, II OR III, PREPARATIONS, PREPARTATION METHODS AND USES THEREOF - Disclosed are levoisovalerylspiramycin I, II or III, preparations, preparing methods and uses thereof. The preparations comprise levoisovalerylspiramycin I, II or III and pharmaceutically acceptable carrier and/or adjuvant, wherein the purity of levoisovalerylspiramycin I, II or III is above 90 wt %. The levoisovalerylspiramycin I, II or III has a good antibacterial activity, and the preparations include solution for injection, powder for injection or lyophilized powder for injection. | 2013-03-14 |
20130065849 | BIPHOTONIC PHOTOSENSITIZERS, NANOPARTICLES CONTAINING THE SAME AND THEIR USE AS DRUGS - The invention relates to compounds of formula (I) | 2013-03-14 |
20130065850 | TREATMENT OF VIRAL INFECTIONS BY MODULATION OF HOST CELL METABOLIC PATHWAYS - Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated. | 2013-03-14 |
20130065851 | ANTI-VIRAL FORMULATIONS - The present disclosure relates generally to the field of anti-viral therapy and prophylaxis. Formulations and agents are provided which inhibit viruses of the Orthomyxoviridae family and ameliorate symptoms and conditions caused by viral infection. The present disclosure teaches the control of influenza virus infection and spread and amelioration of conditions caused thereby. The formulations and agents may be processed as medicaments or as health supplements for more general application such as in the form of consumer goods or consumer foods. | 2013-03-14 |
20130065852 | ANALYSIS OF SULFATED POLYSACCHARIDES - The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described. | 2013-03-14 |
20130065853 | CONTRACEPTIVE METHODS AND COMPOSITIONS - The invention encompasses compositions and methods for use in preventing pregnancy. | 2013-03-14 |
20130065854 | PLANT DISEASE CONTROL COMPOSITION AND ITS USE - A composition comprising a carboxamide compound represented by following formula (I), wherein R | 2013-03-14 |
20130065855 | FUNGICIDE N-[(TRISUBSTITUTEDSILYL)METHYL]-CARBOXAMIDE DERIVATIVES - The present invention relates to fungicidal N-[(trisubstitutedsilyl)methyl]carboxamide or its thiocarboxamide derivative, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions. | 2013-03-14 |
20130065856 | TENOFOVIR ALAFENAMIDE HEMIFUMARATE - A hemifumarate form of 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine (tenofovir alafenamide), and antiviral therapy using tenofovir alafenamide hemifumarate (e.g., anti-HIV and anti-HBV therapies). | 2013-03-14 |
20130065857 | NOVEL DXR INHIBITORS FOR ANTIMICROBIAL THERAPY - The present invention generally concerns particular methods and compositions for antimicrobial therapy. In particular embodiments, the compositions target DXR. In specific embodiments, the compositions are electron-deficient heterocyclic rings. | 2013-03-14 |
20130065858 | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS - The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases. | 2013-03-14 |
20130065859 | SUBSTITUTED 2-(CHROMAN-6-YLOXY)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS - The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, | 2013-03-14 |
20130065860 | 3-(4-(5-PHENYL-1 ,2,4-OXADIAZOL-3-YL)PHENOXY)PROPAN-2-OL DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS - The present invention relates to novel oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors. | 2013-03-14 |
20130065861 | COMPOUNDS (CYSTEIN BASED LIPOPEPTIDES) AND COMPOSITIONS AS TLR2 AGONISTS USED FOR TREATING INFECTIONS, INFLAMMATIONS, RESPIRATORY DISEASES ETC. - The invention provides a novel class of compounds viz. generally lipopeptides like Pam3CSK4, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 2. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness a vaccine. | 2013-03-14 |
20130065862 | FORMULATIONS AND USES OF 2-HYDROXY-5-PHENYLAZOBENZOIC ACID DERIVATIVES - A method of increasing the bioavailability of balsalazide by administration of an oral dosage form with food is provided, as well as an article of manufacture comprising an oral dosage form of balsalazide in a suitable container and associated with printed labeling which describes the increased bioavailability of the medication in the container when taken with food. | 2013-03-14 |
20130065863 | NITROXYL (HNO) RELEASING COMPOUNDS AND USES THEREOF IN TREATING DISEASES - Disclosed is a compound of the formula (I) or a pharmaceutically acceptable salt thereof: (I) in which R | 2013-03-14 |
20130065864 | NOVEL IRIDIUM/RHODIUM ANTI-CANCER COMPOUNDS - The present invention relates to novel iridium and/or rhodium containing complexes for use as a cytotoxic, such as an anti-cancer agent. There is also provided a method of preparing said compounds. | 2013-03-14 |
20130065865 | BARRIER FILM-FORMING GERMICIDAL COMPOSITION FOR CONTROLLING MASTITIS - A long-lasting persistent, uniform film-forming skin protecting germicidal composition provides a long-lasting persistent barrier film when applied to skin. The compositions have particular utility as barrier teat dips for protecting cows against mastitis. A barrier film-forming agent is selected from the modified or hydrolyzed polysaccharides, particularly a hydrolyzed or modified starch, such as dextrin and maltodextrin. The barrier film-forming agent is stably solubilized in a solvent that dries to form the long-lasting persistent uniform film over the animal skin. The compositions also contain antimicrobial agents that fight against microbes that manage to penetrate the protective barrier film. Particularly, advantageous is that all the materials used are safe food additive and cost effective over the traditional barrier film forming agents. | 2013-03-14 |