11th week of 2011 patent applcation highlights part 44 |
Patent application number | Title | Published |
20110065577 | Substituted pyridin-4-yl-methyl sulfonamides as fungicides - The present invention relates to pyridin-4-ylmethyl sulfonamides of formula I | 2011-03-17 |
20110065578 | Substituted Pyridin-4-ylmethyl Sulfonamides - The present invention relates to the use of pyridin-4-ylmethyl sulfonamides of formula (I) (I) wherein R | 2011-03-17 |
20110065579 | Herbicidal Composition Comprising Glyphosate, Glufosinate or Their Salts - The present invention relates to a herbicidal composition which comprises:
| 2011-03-17 |
20110065580 | Use of Succinate Dehyrogenase Inhibitors for Increasing the Content of Desired Ingredients in Crops - The present invention relates to the use of succinate dehydrogenase Inhibitors for increasing the content of desired ingredients in crops, such as fruits and vegetables and to a method for increasing the content of desired ingredients in crops by applying a succinate dehydrogenase inhibitor to the crops prior to the harvest of the crop or of its fruits or vegetables. | 2011-03-17 |
20110065581 | Liquid Compositions Containing S-(+)-Abscisic Acid in Combination with Selected Lipophilic Agents and Methods of their Preparation - The present invention generally relates to liquid compositions of S-(+)-abscisic acid containing selected lipophilic agents, and methods of their preparation for agricultural use. | 2011-03-17 |
20110065582 | ENVIRONMENTALLY FRIENDLY SLOW-RELEASE PESTICIDE FORMULATIONS - The present invention relates to a slow-release pesticide system in agrarian applications that includes but is not limited solely to insecticide, fungicide and herbicide formulations. The system includes a pesticide incorporated into vesicles that is formed by neutral lipids (thereby enhancing the water solubility of the pesticide). The vesicles that incorporate the pesticide are, in turn, adsorbed, on a clay mineral. The formulations are appropriate for pesticide molecules of any type (hydrophobic, acid and basic). Said pesticide formulation allows slow release of the active ingredient, thereby reducing the risk of pollution of groundwater and surface water. | 2011-03-17 |
20110065583 | METHOD FOR INCREASING THE PRODUCTION OF PLANT BIOMASS AND/OR SEEDS AND METHOD FOR PRODUCING PLANT CAPABLE OF PRODUCING INCREASED AMOUNT OF BIOMASS AND/OR SEEDS - The production of biomass and/or seeds is further increased. The production of biomass and/or seeds by a plant can be further increased by supplying glutathione to a plant into which a gene encoding protein phosphatase 2C having characteristic consensus sequences has been introduced. | 2011-03-17 |
20110065584 | Superconducting magnet coil system with quench protection for the prevention of excessive localized currents - A superconducting high-field magnet coil system comprising several radially nested main coil sections ( | 2011-03-17 |
20110065585 | SYSTEMS, METHODS AND APPARATUS FOR MEASURING MAGNETIC FIELDS - SQUIDs may detect local magnetic fields. SQUIDS of varying sizes, and hence sensitivities may detect different magnitudes of magnetic fields. SQUIDs may be oriented to detect magnetic fields in a variety of orientations, for example along an orthogonal reference frame of a chip or wafer. The SQUIDS may be formed or carried on the same chip or wafer as a superconducting processor (e.g., a superconducting quantum processor). Measurement of magnetic fields may permit compensation, for example allowing tuning of a compensation field via a compensation coil and/or a heater to warm select portions of a system. A SQIF may be implemented as a SQUID employing an unconventional grating structure. Successful fabrication of an operable SQIF may be facilitated by incorporating multiple Josephson junctions in series in each arm of the unconventional grating structure. | 2011-03-17 |
20110065586 | SYSTEMS, METHODS AND APPARATUS FOR SUPERCONDUCTING DEMULTIPLEXER CIRCUITS - A switching cell for a demultiplexer circuit includes a superconducting input signal path, at least two superconducting output signal paths, and transformers located between an intersection node and respective ends of the output signal paths. Flux applied via the transformers can influence which direction a signal propagates. The switching cell may also include power input nodes. Switching cells may be arranged in various configurations, for example a binary tree or H-tree. A superconducting inductor ladder circuit can perform a digital-to-analog conversion. Flux storage structures may be used with individual switching cells. Latching qubits may be employed. Buffer rows of switching cells may be used to reduce or eliminate cascade error. | 2011-03-17 |
20110065587 | EPITOPE TESTING USING SOLUBLE HLA - The present invention relates generally to a methodology for assaying the binding of a peptide to an individual, specific, soluble HLA molecule. | 2011-03-17 |
20110065588 | SENSOR ARRAYS AND NUCLEIC ACID SEQUENCING APPLICATIONS - Embodiments of the present invention provide devices methods for sequencing DNA using arrays of reaction regions containing electronic sensors to monitor changes in solutions contained in the reaction regions. Test and fill reaction schemes are disclosed that allow DNA to be sequenced. By sequencing DNA using parallel reactions contained in large arrays, DNA can be rapidly sequenced. | 2011-03-17 |
20110065589 | Devices and Methods of Anonymously Deconvoluting Combined Patient Samples And Combined Patient Assays - Individual patient- and disease-specific test results are obtained from a mixture of one or more distinct tests from multiple combined and distinct patient samples or reactions. In an especially preferred aspect, multiple reaction products from oligonucleotides having unique identifier portions are prepared or received from a clinician and combined for hybridization on a chip. Test results are deconvoluted using a deconvolution table in which associative data are employed to provide access to the individual patient- and disease-specific test results. | 2011-03-17 |
20110065590 | Method and Apparatus for Performing Microassays - A method and apparatus for analyzing a plurality of substances. A platen is provided having two substantially parallel planar surfaces and a plurality of through-holes. An optical arrangement analyzes light emanating from the through-holes. The through-holes may be individually addressable, and may have volumes less than 100 nanoliters. Samples may be accurately dispensed, diluted and mixed in accordance with embodiments of the invention, and may be plated onto walls of the through-holes, and then subsequently resuspended prior to characterization, or, alternatively, retained in the through-holes by surface tension. | 2011-03-17 |
20110065591 | BIOCHIP AND TARGET DNA QUANTITATIVE METHOD - A biochip used for quantitative analysis of a target DNA contained in a sample, includes a type I chamber that includes: a primer that is designed to bind to the target DNA; a internal standard DNA of a first amount that has a sequence different from a sequence of the target DNA, and is amplifiable with the primer; and a fluorescent probe that is designed to bind to a part of an PCR product of the target DNA and to a part of an PCR product of the internal standard DNA, and fluoresces differently for the PCR product of the target DNA and the PCR product of the internal standard DNA, and a type II chamber including: the internal standard DNA of a second amount different from the first amount; and the primer and the fluorescent probe. | 2011-03-17 |
20110065592 | RAPID METHOD FOR IDENTIFYING POLYPEPTIDE-NUCLEIC ACID INTERACTIONS - The invention relates to a method for analysing interactions of a nucleic acid with at least one polypeptide, comprising (a) providing a reaction vessel with a composition comprising cross-linked complexes comprising at least one nucleic acid and at least one polypeptide; (b) immobilizing at least part of the cross-linked complexes to the reaction vessel; (c) at least partially reversing said cross-links in said immobilized complexes by performing a heat incubation step thereby at least partially releasing the nucleic acids from the complexes; (d) analyzing the released nucleic acid. wherein steps (a) to (d) are performed in one reaction vessel. Also provided are specific reaction vessels and kits. | 2011-03-17 |
20110065593 | Computer Methods and Devices for Detecting Kidney Damage - Methods and devices for diagnosing, monitoring, or determining a renal disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining a renal disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described. | 2011-03-17 |
20110065594 | Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual - A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source. | 2011-03-17 |
20110065595 | Method and Test Kit for the Rapid Identification and Characterization of Cells - The invention relates to a rapid method for the characterization and identification of prokaryotic or eukaryotic cells present in a test sample, using an enzyme characterizing a specific strain of cells as a dual marker for cell viability in the presence of a cell inhibitory agent, and as a structural marker for cell identification. The method of the invention is based on change in the enzymatic activity of the enzyme in a tested sample in the presence of different cell inhibitory agents and/or different recognition-agents, preferably, antibodies. The invention further provides kits for rapid characterization and identification of prokaryotic or eukaryotic cells present in a test sample. | 2011-03-17 |
20110065596 | DIRECTED EVOLUTION USING PROTEINS COMPRISING UNNATURAL AMINO ACIDS - The invention provides methods and compositions for screening polypeptide libraries that include variants comprising unnatural amino acids. In addition, the invention provides vector packaging systems and methods for packaging a nucleic acid in a vector. Compositions of vectors produced by the methods and systems are also provided | 2011-03-17 |
20110065597 | SINGLE MOLECULE PROTEOMICS WITH DYNAMIC PROBES - Methods are disclosed utilizing single-molecule proteomics with dynamic probes to accomplish a variety of protein analytic applications. A panel of probes, when used in combination, can resolve and quantify a proteome in a simple assay detecting transient binding to single protein targets. | 2011-03-17 |
20110065598 | Methods and Devices for Detecting Diabetic Nephropathy and Associated Disorders - Methods and devices for diagnosing, monitoring, or determining diabetic nephropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining diabetic nephropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described. | 2011-03-17 |
20110065599 | Methods and Devices for Detecting Kidney Damage - Methods and devices for diagnosing, monitoring, or determining kidney damage in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney damage using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described. | 2011-03-17 |
20110065600 | SEQUENCES ASSOCIATED WITH TDP-43 PROTEINOPATHIES AND METHODS OF USING THE SAME - Nucleic acids and peptides and methods of using thereof to identify subjects at risk for a TDP-43 proteinopathy are disclosed An array is also disclosed which contains the nucleic acids and peptides | 2011-03-17 |
20110065601 | IDENTIFICATION OF DISCRIMINANT PROTEINS THROUGH ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING AN INDIVIDUAL - A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source. | 2011-03-17 |
20110065602 | METHOD FOR DETECTION OF GENE TRANSCRIPTS IN BLOOD AND USES THEREOF - The present invention relates generally to the identification of biomarkers of conditions including disease and non disease conditions as well as identifying compositions of biomarkers. The invention further provides a method of diagnosing disease, monitoring disease progression, and differentially diagnosing disease. The invention further provides for kits useful in diagnosing, monitoring disease progression and differentially diagnosing disease. | 2011-03-17 |
20110065603 | Method for a Highly Sensitive Detection and Quantification of Biomolecules Using Secondary Ion Mass Spectrometry (SIMS) and Related Technologies - The present invention relates to a method for detecting and quantifying the presence or absence of a number of biomolecules in a sample using the SIMS technique and arrays for use in said method. | 2011-03-17 |
20110065604 | Element Defined Sequence Complexity Reduction - A method for providing defined mixtures of nucleic acids is described. In certain embodiments, the method uses oligonucleotide probes attached to a solid support as a sequence-specific affinity agent to isolate and facilitate the amplification of defined nucleic acid fragment mixtures. | 2011-03-17 |
20110065605 | METHOD FOR BIOMARKER AND DRUG-TARGET DISCOVERY FOR PROSTATE CANCER DIAGNOSIS AND TREATMENT AS WELL AS BIOMARKER ASSAYS DETERMINED THEREWITH - The invention relates to a method for the determination of a cancer diagnostic/therapeutic biomarker assay and drug-targets including the following steps: (a) identification of potential candidate protein/peptide biomarkers and drug-targets based on the measurement of protein/peptide constituent concentrations in tissue sample proteomes as well as serum, plasma or any other derivatives of blood, or blood itself sample proteomes derived from healthy non-human mammalian individuals as well as from cancerous non-human mammalian individuals and qualitatively selecting as potential candidate protein/peptide biomarkers those which show a pronounced differential behaviour between healthy and cancerous sample proteomes; (b) optional verification of the potential candidate protein/peptide biomarkers as identified in step (a) by quantitative mass spectrometric measurement of the potential candidate protein biomarkers in serum, plasma or any other derivatives of blood, or blood itself sample proteomes derived from healthy non-human mammalian individuals as well as from cancerous non-human mammalian individuals and selecting as candidate protein/peptide biomarkers those which show a mass-spectrometrically measurable quantitative differential behaviour between healthy and cancerous sample proteomes; (c) validation of the candidate protein/peptide biomarkers as identified in step (a), or as optionally verified in step (b), by mass spectrometric measurement and/or antibody-based assays such as an Enzyme-Linked Immunosorbent Assay (ELISA) determination of the candidate protein biomarkers in serum, plasma or any other derivatives of blood, or blood itself sample proteomes derived from healthy human individuals as well as from cancerous human individuals and selecting as protein/peptide biomarkers those which show a mass-spectrometrically measurable and/or antibody-based assay detectable differential behaviour between healthy and cancerous sample proteomes; (d) application of statistical methods to uncover single or groups of protein/peptide biomarkers as validated in step (c) as signatures for the detection of patients with cancer. The invention furthermore relates to specific biomarker assays for the highly reliable diagnosis of cancer, specifically of localized or non-localized prostate cancer, using human serum, plasma or any other derivatives of blood, or blood itself. | 2011-03-17 |
20110065606 | PRODUCTION OF NUCLEIC ACID - The present invention provides a process for the production of nucleic acid encoding a target protein, which comprises: (a) providing an array of RNA or DNA molecules including one or more encoding the target protein; (b) generating a target protein from the array to form RNA-protein or DNA-protein complexes in which the RNA or DNA molecule is non-covalently or covalently bound to the complex; (c) separating the complexes into compartments wherein most or all of the compartments contain no more than one complex; (d) subjecting the complexes to reaction conditions which allow target protein activity; and (e) selecting nucleic acid encoding the target protein on the basis of the activity associated therewith, wherein when the complex is a DNA-protein complex in which the DNA is non-covalently bound, step b) is performed in the absence of separate compartments for each complex. | 2011-03-17 |
20110065607 | CENTROID MARKERS FOR IMAGE ANALYSIS OF HIGH DENISTY CLUSTERS IN COMPLEX POLYNUCLEOTIDE SEQUENCING - Improved compositions, methods, apparatus, and kits for high-throughput nucleic acid amplification, detection and sequencing are disclosed. A nucleic acid cluster having an identifiable center is produced by generating on a solid support an immobilized nucleic acid complement from a template, one of which comprises a detectable label; and amplifying the complement and the template to obtain a nucleic acid cluster on the support, the cluster having a substantially central location marked by the detectable label and a surrounding region comprising immobilized copies. Also disclosed are nucleotide sequence determination in nucleic acid clusters so produced, center position annotation in the clusters, assignment of sequence information to overlapping clusters, and related compositions and methods. | 2011-03-17 |
20110065608 | Devices for Detecting Renal Disorders - Devices for diagnosing, monitoring, or determining a renal disorder in a mammal are described. In particular, devices for diagnosing, monitoring, or determining a renal disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described. | 2011-03-17 |
20110065609 | Methods and Kits for the Diagnosis of Rheumatoid Arthritis - The present invention relates to the identification and use of proteins with clinical relevance to rheumatoid arthritis (RA). In particular, the invention provides the identity of marker proteins that specifically react with RA-associated autoantibodies. Also provided are methods, arrays and kits for using these proteins in the diagnosis of RA, and in the selection and/or monitoring of treatment regimens. | 2011-03-17 |
20110065610 | Synthetic Polypeptide Libraries and Methods for Generating Naturally Diversified Polypeptide Variants - The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence. | 2011-03-17 |
20110065611 | Apparatus for treatment of light-sensitive biopolymers - A method of fabricating a device comprising an array of test locations defined on a substrate with each test location comprising one or more identical oligonucleotides affixed to the substrate. The method comprises the steps of:
| 2011-03-17 |
20110065612 | LOW INTERFACIAL TENSION SURFACTANTS FOR PETROLEUM APPLICATIONS - The invention relates to a class of novel surfactants that have utility in the recovery and/or extraction of oil. | 2011-03-17 |
20110065613 | OIL-BASED INSULATING PACKER FLUID - A packer or annular fluid includes a hydrocarbon fluid; and a gelling agent; wherein the packer fluid is a yield power law fluid. A method for preparing a packer fluid includes preparing a mixture of a hydrocarbon fluid, and a gelling agent; heating the mixture to a selected temperature; and shearing the mixture. A method for emplacing a packer fluid into an annulus includes preparing the packer fluid that includes a hydrocarbon fluid and a gelling agent, wherein the packer fluid is a yield power law fluid; and pumping the packer fluid into the annulus. | 2011-03-17 |
20110065614 | CORROSION INHIBITOR FOR ACID STIMULATION SYSTEMS - An oil well being subjected to an acid stimulation may be treated with a corrosion inhibitor including an Ammonium Iodide Ion Source, a first carbonyl containing compound having a general formula: | 2011-03-17 |
20110065615 | REDUCED MOLYBDENUM GREASE FORMULATION - Extreme pressure additives may be added to greases to improve their lubricating properties, particularly to decrease friction and wear of parts that are exposed to very high pressures. Molybdenum disulfide is frequently used as an extreme pressure additive. However, molybdenum disulfide is expensive, has limited availability, and may have adverse environmental effects. This invention discloses an extreme pressure additive and grease formulation where the amount of molybdenum disulfide is reduced through the addition of calcium carbonate while the performance characteristics of the grease are maintained or improved. The extreme pressure additive may comprise about 20% molybdenum sulfide and about 80% calcium carbonate, by weight. | 2011-03-17 |
20110065616 | SHAPE MEMORY COMPOSITION COMPRISING STARCH - The present invention relates to a method of forming a composition with a shape in memory from a composition comprising 30% to 100% of starch and/or starch derivatives, compositions with a shape in memory which can be obtained by this method and use of these compositions. | 2011-03-17 |
20110065617 | METAL CONTAINING HYDRAULIC COMPOSITIONS - The present invention relates to a lubricating composition containing an oil of lubricating viscosity, a metal containing antiwear agent and a metal containing dispersant. The invention further provides for a method for lubricating a hydraulic system. | 2011-03-17 |
20110065618 | LUBRICANT OIL COMPOSITION FOR INTERNAL COMBUSTION ENGINE - The lubricating oil composition for an internal combustion engine of the invention comprises a lubricating base oil having a urea adduct value of not greater than 4% by mass and a viscosity index of 100 or greater, an ash-free antioxidant containing no sulfur as a constituent element, and at least one compound selected from among ash-free antioxidants containing sulfur as a constituent element and organic molybdenum compounds. | 2011-03-17 |
20110065619 | FUEL AND ENGINE OIL COMPOSITION AND ITS USE - A composition is provided that contains a major amount of a base oil and a minor amount of at least one butylene oxide-modified alkyl-bis-ethoxylated monoamine, wherein the alkyl group have carbon atoms in the range of 8 to 22 and ethylene oxide to butylenes oxide is in a ratio in the range of about 3:1 to about 2:1. The composition provides improved friction modification in fuel and in lubricating oils. | 2011-03-17 |
20110065620 | TERNARY AZEOTROPES CONTAINING 1,1,2,2,3,4,5,5,5-DECAFLUORO-3-METHOXY-4-(TRIFLUOROMETHYL)-PENTANE AND COMPOSITIONS MADE THEREFROM - Compositions are provided that include blends that consist essentially of 1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)pentane, trans-1,2-dichloroethylene, and a third component. The third component is selected from methanol, ethanol, isopropanol, t-butanol, and 1-propanol. The blends form ternary azeotropes. Provided compositions can be useful for cleaning electronic parts, as coating solvent components, as heat transfer fluids, and as lubricants. | 2011-03-17 |
20110065621 | MATERIAL FOR CLEANING A SUBSTRATE - Material for cleaning using a tri-state body are disclosed. A substrate having a particle deposited thereon is provided. A tri-state body that has a solid portion, liquid portion, and a gas portion is generated. A force is applied over the tri-state body to promulgate an interaction between the solid portion and the particle. The tri-state body is removed along with the particle from the surface of the substrate. The interaction between the solid portion and the particle causes the particle to be removed along with the tri-state body. | 2011-03-17 |
20110065622 | NOVEL NITRILE AND AMIDOXIME COMPOUNDS AND METHODS OF PREPARATION FOR SEMICONDUCTOR PROCESSING - Semiconductor processing compositions comprising amidoxime compounds having two or more amidoxime functional groups and their use in semiconductor processing to remove photoresist, polymeric materials, etching residues and copper oxides from semiconductor substrates, particularly substrates comprising copper, low-k dielectric material, titanium nitride, and/or titanium oxynitride. | 2011-03-17 |
20110065623 | SOLID CLEANING PRODUCTS - Solid cleaning products suitable for use as a floor cleaner are disclosed. Methods of making and using solid cleaning products are also disclosed. | 2011-03-17 |
20110065624 | FLUID LAUNDRY DETERGENT COMPOSITION - Compact fluid laundry compositions comprising polymer deposition aids and multivalent water-soluble builders and/or chelants can be stabilized using external structurant systems. | 2011-03-17 |
20110065625 | EXTERNAL STRUCTURING SYSTEM FOR LIQUID LAUNDRY DETERGENT COMPOSITION - Liquid or gel-form detergents can be externally structured with a structuring system comprising crystallizable glyceride(s) emulsified with an alkanolamine-neutralized anionic surfactant. Crystallizable glyceride(s) of use include hydrogenated castor oil. The liquid or gel-form detergents may be packaged in unit dose form. | 2011-03-17 |
20110065626 | DETERGENT COMPOSITION - The present invention relates to a liquid detergent comprising less than 40% total water or non-amino functional solvent, alkyl benzene sulphonate surfactant comprising greater than 20% of the 2 phenyl isomer and a gel breaker selected from the group consisting of amino alcohol compounds having a molecular weight above 61 g/mol, wherein the composition has a ratio of total surfactant to total solvent of greater than 1:1. | 2011-03-17 |
20110065627 | Transdermal delivery of medicaments with combinations of cetylated fatty fatty ester penetrant complexes - This invention describes a topical delivery mechanism that contains a mixture of cetylated fatty esters that act as transdermal carriers of desired therapeutic molecules. The proposed cetyl fatty ester penetrant-complex (Base CFEP-complex) contains specific cetyl fatty esters, polar solvents, a carrier base (gel, cream, lotion, patch or stick gel), antioxidants and the desired pharmaceutical, cosmetic or antigenic response eliciting molecules that are efficaciously delivered by selectively varying component ratios in the complex. The invention proposes the use of transdermal delivery of medications such as those used in treatment of urinary incontinence, testosterone deficiency, arthritic and joint pain and other pains such as pain in the neck, lower back, back, knees, headaches, and other types of inflammatory pains, peripheral neuropathic pain, pain associated with repetitive strain injuries such as myofacial pain, rapid treatment of epileptic seizures, soluble antigens in the immuno-therapeutic treatment of allergies, actives in the treatment of foot cracks and elbow cracks, actives in the treatment of facial and other wrinkles in the form of anti-aging creams and gels and other topically delivered therapies. | 2011-03-17 |
20110065628 | Medication Combinations for the Treatment of Alcoholism and Drug Addiction - The present invention provides for the use of combinations of drugs to treat addictive disorders. More specifically, the present invention provides compositions and methods for treating disorders using combinations of drugs such as topiramate, ondansetron, and naltrexone. | 2011-03-17 |
20110065629 | ENTERAL NUTRIENT - The present invention relates to an enteral nutrient for inflammatory bowel disease patients, including an active hexose correlated compound obtained by culturing mycelia of basidiomycetes. The enteral nutrient of the present invention is an enteral nutrient which is expected to exhibit an advantageous effect of AHCC on cancer patients and an action of alleviating inflammation in inflammatory bowel diseases, and to exhibit an action of inhibiting inflammation in patients who are suffering from ulcerative colitis or Crohn's disease and thus have difficulty with oral nutritional intake. | 2011-03-17 |
20110065630 | USE OF A OCTREOTIDE AS A THERAPEUTIC AGENT - The present invention is directed to the use of the peptide compound D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent. | 2011-03-17 |
20110065631 | PROCESS FOR PREPARATION OF HIV PROTEASE INHIBITORS - A process for the synthesis of bisfuran intermediates of formula (0) useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed. Furthermore disclosed is a HIV protease inhibitor of formula (IV) as well as various intermediates thereof. | 2011-03-17 |
20110065632 | PHARMACEUTICAL COMPOSITIONS OF SOMATOSTATIN-DOPAMINE CONJUGATES - The present invention is directed to improvements in compositions containing a somatostatin-dopamine conjugate which retains both somatostatin and dopamine activity in vivo, methods for preparing such compositions, and method of using such compositions to treat mammals. In particular, the present invention relates to a pharmaceutical composition comprising Dop2-DLys(Dop2)-cyclo[Cys-Tyr-DTrp-Lys-Abu-Cys]-Thr-NH | 2011-03-17 |
20110065633 | ESTER-BASED PEPTIDE PRODRUGS - Prodrug formulations of bioactive polypeptides are provided wherein the bioactive polypeptide has been modified by the linkage of a dipeptide to the bioactive polypeptide through an ester linkage. The prodrugs disclosed herein in some embodiments have extended half lives of at least 1.5 hours (e.g., at least 10 hours), and more typically greater than 20 hours and less than 70 hours, and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability. | 2011-03-17 |
20110065634 | GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE - The present invention relates to compounds of general formula (I), wherein ring A, ring B, R | 2011-03-17 |
20110065635 | METHODS AND COMPOSITIONS FOR MODULATING INSULIN REGULATION - The present invention provides a combination of compounds capable of modulating xenin activity and, insulin secretion and weight gain. The invention also provides methods for modulating GIP activity and insulin secretion in a subject, by modulating xenin activity in the subject. | 2011-03-17 |
20110065636 | Screening and Therapy for Lymphatic Disorders Involving the FLT4 Receptor Tyrosine Kinase (VEGFR-3) - The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects. | 2011-03-17 |
20110065637 | Method to reduce SLOSH energy absorption and its damaging effects through the reduction of inelastic collisions in an organism - A first embodiment can be a method to reduce SLOSH energy absorption within an organism by reducing the inelastic collisions. A fluid containing organism can utilize an embodiment of the method wherein one or more of reversibly increasing pressure within the organs or cells, reversibly increasing the volume within the organs or cells, reversibly altering vascular, molecular, or cell wall stiffness, or reversibly altering vascular, molecular, or cell wall configuration within said organism may reduce these collisions. | 2011-03-17 |
20110065638 | NOVEL CRUSTACEAN ANDROGENIC GLAND HORMONE - The present invention relates to a novel crustacean androgenic gland hormone. More specifically, the invention relates to an androgenic gland hormone derived from | 2011-03-17 |
20110065639 | COMPOSITIONS AND METHODS FOR VISUALIZING AND ELIMINATING CANCER STEM CELLS - The present invention relates generally to the field of cancer diagnosis and treatment, and more particularly to compositions and methods that may be useful for eliminating cancer cells with stem-like characteristics. The disclosed compositions and methods may also be useful for managing breast cancer, ovarian cancer, cervical cancer or endometrial (uterine) cancer with metastases; and visualizing the cancer cells in patient's body. The compositions of the instant invention include human prolactin receptor antagonist G129R. | 2011-03-17 |
20110065640 | ANTI-INVASIVE AND ANTI-ANGIOGENIC COMPOSITIONS - A peptide compound having the sequence Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu [SEQ ID NO:2] or a substitution variant, addition variant or other chemical derivative thereof inhibits cell invasion, endothelial tube formation or angiogenesis in vitro. A number of substitution variants and addition variants of this peptide, preferably capped at the N- and C-termini, as well as peptidomimetic derivates, are useful for treating diseases and conditions mediated by undesired and uncontrolled cell invasion and/or angiogenesis. Pharmaceutical compositions comprising the above peptides and derivatives are administered to subjects in need of such treatment in a dosage sufficient to inhibit invasion and/or angiogenesis. The disclosed compositions and methods are particularly useful for suppressing the growth and metastasis of tumors. | 2011-03-17 |
20110065641 | POLYPEPTIDE AND DNA THEREOF USEFUL AS A NEOVASCULAR MARKER - A marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease and cancer, the method of detection of the marker and a diagnosis kit of the diseases are provided. Additionally, therapeutic agents of the diseases are provided. | 2011-03-17 |
20110065642 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE AND/OR CORNEAL AND CONJUNCTIVAL LESION - The present invention provides a pharmaceutical composition for the treatment of dry eye and/or corneal and conjunctival lesion which comprises a recombinant human serum albumin produced by a recombinant yeast obtained by transforming a yeast with a gene for human serum albumin. Further, the present invention provides a method for the treatment of dry eye and/or corneal and conjunctival lesion, which comprises administering an effective amount of a recombinant human serum albumin produced by a recombinant yeast obtained by transforming a yeast with a gene for human serum albumin to a subject in need of the treatment of eye and/or corneal and conjunctival lesion. | 2011-03-17 |
20110065643 | Clusterin Pharmaceuticals and Treatment Methods Using the Same - Disclosed are pharmaceutical compositions comprising clusterin and polypeptides substantially the same as clusterin and treatment methods for inflammatory diseases and dry eye disease. The pharmaceutical compositions include an isolated clusterin or an isolated polypeptide substantially the same as clusterin. The clusterin is preferably secreted clusterin. The method of treating dry eye disease includes administering to a patient in need an effective amount of a pharmaceutical composition comprising an isolated clusterin or an isolated polypeptide substantially the same as clusterin. The method of treating a disease state characterized by inflammation includes administering to a patient having the disease state an amount of isolated clusterin or a protein substantially the same as clusterin effective to decrease the activity of a matrix metallproteinase selected from the group consisting of MMP-9, MMP-2 and MMP-7. | 2011-03-17 |
20110065644 | COMPOSITIONS COMPRISING HUMAN PCSK9 AND APOLIPOPROTEIN B SIRNA AND METHODS OF USE - The present invention provides siRNA nucleic acid molecules that inhibit PCSK9 or apolipoprotein B expression. Methods of using the nucleic acid molecules are also provided. | 2011-03-17 |
20110065645 | Compositions and Methods for Modulating Neuron Degeneration and Neuron Guidance - Methods for inhibiting degeneration of a neuron, methods of treating a neurodegenerative disease, methods for promoting degeneration of a neuron are provided, methods for modulating neuron cell guidance of a neuron, as well as compounds useful in the methods of the invention, such as a Wnt compound, a Fzd3 dephosphorylating agent, a Fzd3 phosphorylating agent, or a SHH compound as disclosed herein. | 2011-03-17 |
20110065646 | Use of a Homeoprotein of the Bicoid Family for Preventing or Treating Retinal Ganglionic Neuron Degeneration - The invention relates to the use of a homeoprotein of the bicoid family, in particular of the Otx family, for enhancing the survival of cultivated retinal ganglion neurones, and for preventing or treating ganglion neuron degeneration particularly occurring in glaucoma. | 2011-03-17 |
20110065647 | NOVEL PEPTIDES ISOLATED FROM SPIDER VENOM, AND USES THEREOF - The presently described subject matter relates to isolated spider venom peptides, which are used as potent and selective ion channel blockers, and to a composition and methods for treatment of pain. | 2011-03-17 |
20110065648 | ADVANTAGEOUS MU-OPIATE RECEPTOR PEPTIDE COMPOUNDS - The subject invention provides advantageous new salts of mu-opiate receptor peptides. These salts have been found to have excellent properties in terms of their activity. | 2011-03-17 |
20110065649 | USE OF MULTIVALENT SYNTHETIC LIGANDS OF SURFACE NUCLEOLIN FOR TREATING CANCER OR INFLAMMATION - A method for treating disorders involving deregulation of cell proliferation and/or angiogenesis comprising the administration of an effective amount of a multivalent synthetic compound comprising a support on which at least 3 pseudopeptide units are grafted, said compound being of formula (I). | 2011-03-17 |
20110065650 | Methods of Inhibiting Tumor Cell Proliferation - The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. The invention also provides methods for preventing tumor progression in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization. Furthermore, the invention provides methods for inhibiting tumor cell growth in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization in tumor cells in the animal. | 2011-03-17 |
20110065651 | HETEROCYCLIC SUBSTITUTED PIPERAZINES WITH CXCR3 ANTAGONIST ACTIVITY - The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: | 2011-03-17 |
20110065653 | TAT-UTROPHIN AS A PROTEIN THERAPY FOR DYSTROPHINOPATHIES - Disclosed is a fusion protein including a full-length TAT-utrophin or an anti-dystrophinopathic fragment thereof, a method of treating dystrophinopathies (including Duchenne muscular dystrophy) using the fusion protein, a pharmaceutical composition for treating dystrophinopathies in mammals comprising the fusion protein, and nucleic acid constructs for expressing the fusion protein. | 2011-03-17 |
20110065654 | COMPOSITIONS AND METHODS FOR ALZHEIMER'S DISEASE - The present invention concerns methods and compositions of use for treatment of Alzheimer's Disease (AD). In certain embodiments, the methods concern preparation of phage-display single chain antibody libraries and screening against amyloid-beta (Aβ) protein or peptide. Anti-Aβ antibodies are selected and sequenced. In certain embodiments, synthetic Aβ binding peptides are designed and prepared, using portions of the anti-Aβ antibody sequences. The antibodies and peptides are of use for treatment of AD or for treatment of individuals at risk of developing AD. Compositions comprising anti-Aβ antibodies or Aβ binding peptides are also disclosed. | 2011-03-17 |
20110065655 | THERAPEUTIC COMPOSITION TO TREAT LESIONS CAUSED BY HERPES SIMPLEX VIRUS - The present invention is generally directed toward therapeutic compositions for treating infections caused by Herpes Simplex Virus (“HSV”). The therapeutic compositions meet a long felt need in the art of providing a treatment for lesions that result from HSV that drastically reduce the duration of a cold sore when vesicles have already appeared and a treatment that will prevent the outbreak of a lesion and formation of vesicles when applied in the prodormal stage. The therapeutic compound comprises a mixture of Acyclovir (“ACV”), Penciclovir (“PCV”), and 2-Deoxy-D-Glucose (“2-DDG”). The therapeutic compositions of the present invention include multiple formulations of the three active ingredients and may also include inactive ingredients. | 2011-03-17 |
20110065656 | DOPAMINERGIC MIMETICS - A method is described for providing acute symptomatic relief to a subject with Parkinson's Disease (PD) or other CNS disorders resulting from dopamine deficiency in the brain comprising administering to said subject an amount of a ketogenic material sufficient to produce a ketosis in the subject sufficient to provide therapeutic benefit in such neurological disorders. Preferred materials produce a ketosis is such that the total concentration of acetoacetate and (R)-3-hydroxybutyrate in the blood of the subject is raised to between 0.1 and 30 mM. | 2011-03-17 |
20110065657 | Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases - Polyhydroxylated aromatic compounds, and compositions containing them, are useful for the treatment of amyloidosis, especially Alzheimer's disease, and for the treatment of diseases characterized by α-synuclein fibril formation, especially Lewy body disease and Parkinson's disease. | 2011-03-17 |
20110065658 | METHOD FOR TREATING HYPERURICEMIA EMPLOYING AN SGLT2 INHIBITOR AND COMPOSITION CONTAINING SAME - Methods are provided for treating hyperuricemia, employing an SGLT2 inhibitor alone, or in combination with a supply of carbohydrate, and/or in combination with an inhibitor of uric acid synthesis. Additionally, pharmaceutical compositions comprising an SGLT2 inhibitor with a supply of carbohydrate or an inhibitor of uric acid synthesis or a supply of carbohydrate and an inhibitor of uric acid synthesis are provided in the instant invention and are provided for use in the inventive methods. | 2011-03-17 |
20110065659 | PROTOPANAXADIOL-TYPE GINSENOSIDE COMPOSITIONS AND USES THEREOF - Provided herein are ginsenoside compositions comprising at least 10% (w/w) of a protopanaxadiol type of ginsenoside suitable for administration to a subject. Also provided are methods using the ginsenoside compositions for reducing acetaldehyde concentrations, preventing or ameliorating a symptom of elevated acetaldehyde concentration, or reducing the risk of diseases or disorders caused by the intake of ethyl alcohol. | 2011-03-17 |
20110065660 | Chemosensory Receptor Ligand-Based Therapies - Provided herein are methods for treating diabetes, obesity, and other metabolic diseases, disorders or conditions comprising chemosensory receptor ligands. Also provided herein are chemosensory receptor ligand compositions and the preparation thereof for the methods of the present invention. | 2011-03-17 |
20110065661 | PHARMACOPERONES FOR CORRECTING DISEASE STATES INVOLVING PROTEIN MISFOLDING - This application relates to methods of identifying pharmacoperone agents that can restore function to a misfolded protein, such as a misfolded protein that causes disease. Also disclosed are methods of using such pharmacoperone agents to treat a disease or disorder that results from the misfolded protein. | 2011-03-17 |
20110065662 | Compounds, Compositions, and Methods for Protecting Brain Health in Neurodegenerative Disorders - Aspects of the invention relate to compounds, extracts and compositions thereof, and methods of using of the same, to treat neurodegenerative disorders and/or improve brain health. In certain embodiments, said compounds are pomegranate flavonoids. | 2011-03-17 |
20110065663 | ANTI-CANCER COMBINATION THERAPY - The present invention relates to a combination of therapeutic agents comprising: (a) a cytosine-based anti-cancer drug and/or a purine-based anticancer drug and (b) a therapeutic agent selected from the group consisting of thymidine phosphorylase inhibitors, and antibiotics against Mollicutes bacteria. The present invention also relates to the simultaneous, separate or sequential use of said combination for the treatment of cancer in mammals, especially in humans. The present invention also relates to methods of treatment of cancer, preferably in mammals infected with Mollicutes bacteria. | 2011-03-17 |
20110065664 | KINASE PROTEIN BINDING INHIBITORS - The invention relates to phosphorylation inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating cell proliferative disorders, especially cancer. | 2011-03-17 |
20110065665 | STABILIZATION OF VITAMIN B12 - The invention relates to preparations comprising vitamin B | 2011-03-17 |
20110065666 | METHOD OF PRODUCING A BRAN PRODUCT - The present invention relates to a method of manufacturing a cereal bran product containing beta-glucan. According to the method, a plastic mass is formed from cereal bran by means of a thermo-mechanical treatment, and the mass is brought into contact with an enzyme that breaks up beta-glucan, with or without an enzyme that breaks up starch. After inactivating the enzyme, the bran is dried and, when so needed, ground. The cereal bran product manufactured according to the method has an essentially inextensible structure in a water environment. The product is suitable to be added to aqueous foodstuffs or to foodstuffs, the manufacture of which employs water. | 2011-03-17 |
20110065667 | PHENYLPYRAZOLE DERIVATIVES - The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases. | 2011-03-17 |
20110065668 | PHENYLPYRAZOLE DERIVATIVES - The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases. | 2011-03-17 |
20110065669 | OXAZOLOBENZIMIDAZOLE DERIVATIVES - The present invention is directed to oxazolobenzimidazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved. | 2011-03-17 |
20110065670 | Skin Beautifier - A skin beautifier contains sphingomyelin, which is a phospholipid, as an effective ingredient. In addition, skin-beautifying food or feed contains sphingomyelin as an effective ingredient. The present invention provides a skin beautifier and skin-beautifying food or feed supplying effects on beauty, such as skin-moisturizing and protecting effects, skin-roughness-preventing and improving effects, and a wrinkle-preventing effect, by oral ingestion thereof. | 2011-03-17 |
20110065671 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS - The present invention relates to Bicyclic Heterocycle Derivatives of formula (I), compositions comprising a Bi-cyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR1 19 in a patient. | 2011-03-17 |
20110065672 | BISPHOSPHONATE-PROSTATIC ACID PHOSPHATASE INHIBITOR CONJUGATES TO TREAT PROSTATE CANCER BONE METASTASIS - The present invention concerns conjugate compounds comprising a bisphosphonate covalently bonded to a prostatic acid phosphatase inhibitor and compositions comprising such conjugates. Methods for treating and inhibiting prostate cancer bone metastases, and determining whether a conjugate is useful for such treatment are also provided. In some instances, the bisphosphonate is alendronate, and it is covalently bonded to either tartaric acid or glyceric acid. | 2011-03-17 |
20110065673 | NOVEL LEUKOTRIENE RECEPTOR AGONIST - It is an object of the present invention to provide a leukotriene receptor antagonist that can be conveniently prepared from a natural source. | 2011-03-17 |
20110065674 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION - The invention relates to methods and compositions for improving cognitive function by using a combination of valproic acid and analogs and derivatives thereof (“valproate”) and an acetylcholinesterase inhibitor (AChEI). In particular, it relates to the use of a combination of a valproate and an AChEI in treating age-related cognitive impairment in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for Mild Cognitive Impairment (MCI), Age-Associated Memory Impairment (AAMI) or Age-Related Cognitive Decline (ARCD). | 2011-03-17 |
20110065675 | AZO DYE RELATED SMALL MOLECULE MODULATORS OF PROTEIN-PROTEIN INTERACTIONS - Azo dyes and suramin-related small molecules are effective in inhibiting the CD40/CD154 protein-protein interaction, an important co-stimulatory interaction involved in the activation of immune responses mediated by T- and B-cells. The compounds were found to be active as indicated by their IC | 2011-03-17 |
20110065676 | COMBINATION THERAPIES COMPRISING PAR1 ANTAGONISTS WITH NAR AGONISTS - The present invention is directed to a pharmaceutical composition comprising an effective amount of at least one PAR1 antagonist, at least one NAR agonist, optionally, an effective amount of at least one cardiovascular agent, and, optionally, a pharmaceutically acceptable carrier. The present invention also provides for the use of theses pharmaceutical compositions to treat various diseases associated with thrombosis. | 2011-03-17 |
20110065677 | Methods of Treating Inflammation with Compositions Comprising Lecithin Oils and NSAIDS for Protecting the Gastrointestinal Tract and Providing Enhanced Therapeutic Activity - A novel pharmaceutical composition is provided by which nonsteroidal anti-inflammatory drugs (NSAIDs) are added directly to phospholipid-containing oil such as lecithin oils or to a bio-compatible oil to which an phospholipid has been added to make a NSAID-containing formulation that possess low gastrointestinal (GI) toxicity and enhanced therapeutic activity to treat or prevent inflammation, pain, fever, platelet aggregation, tissue ulcerations and/or other tissue disorders. The composition of the invention are in the form of a non-aqueous solution, paste, suspension, dispersion, colloidal suspension or in the form of an aqueous emulsion or microemulsion for internal, oral, direct or topical administration. | 2011-03-17 |