11th week of 2016 patent applcation highlights part 10 |
Patent application number | Title | Published |
20160074483 | THERAPEUTIC PEPTIDE-EXPRESSING CELLS - Provided herein are cells for in vivo expression of therapeutic proteins or peptides, methods of making and using the same. | 2016-03-17 |
20160074484 | NUCLEOTIDE PHOSPHATE DISSIPATION AS A TREATMENT FOR VASCULAR DISORDERS - The present invention provides a method of treating or preventing immunoinflammatory, vascular, thrombotic or ischemic disorders in a subject, the method comprises administering to the subject an agent which dissipates nucleotide phosphates or generates a product which stimulates adenosine receptors. The present invention also provides a method of treating or preventing immunoinflammatory, thrombotic or ischemic disorders in a subject by inhibiting leukocyte infiltration into a site which comprises administering to the subject an effective amount a described agent. Agents described for use in the methods of the invention include CD73, a fragment a mutant, or a modified form thereof. | 2016-03-17 |
20160074485 | METHODS FOR TREATING OSTEOARTHRITIS PAIN - Methods for alleviating osteoarthritis-associated symptoms by selecting a treatment-eligible patient and local administration of a clostridial derivative, such as a botulinum toxin, to an osteoarthritis-affected site are disclosed herein. | 2016-03-17 |
20160074486 | THERAPEUTIC COMPOSITION WITH A BOTULINUM NEUROTOXIN - The present invention pertains to pharmaceutical compositions which comprise botulinum toxin from | 2016-03-17 |
20160074487 | ARGININE DEIMINASE WITH REDUCED CROSS-REACTIVITY TOWARD ADI - PEG 20 ANTIBODIES FOR CANCER TREATMENT - The present invention relates generally to isolated to arginine deiminase (ADI) proteins that have reduced cross-reactivity with anti-ADI-PEG 20 antibodies as compared to ADI-PEG 20, but which can have functional characteristics comparable to or better than ADI-PEG 20, compositions comprising the ADI proteins, and related methods of treating arginine-dependent diseases or related diseases such as cancer. | 2016-03-17 |
20160074488 | METHODS AND COMPOSITIONS INVOLVING FIBRILLIZING POLYPEPTIDES FOR NANOFIBERS - Embodiments of the invention are directed to fibrillar adjuvants. For example, epitopes assembled by a synthetic peptide domain into nanofibers comprising a β-fibrillization peptide may elicit high antibody titers in the absence of any adjuvant. In certain embodiments, multiple different antigens may be integrated into polypeptide nanofibers, providing biomaterials with modular and precise composition of bioactive proteins. | 2016-03-17 |
20160074489 | STIMULATION OF IMMUNITY TO TUMOR SPECIFIC AND ENDOTHELIAL SPECIFIC PROTEINS BY IN VIVO DC ATTRACTION AND MATURATION - Treatment of cancer is disclosed through administration of proteins or specific peptides in vivo, in a matter eliciting monocyte or dendritic cell migration in order to allow uptake of said administrated proteins or peptides, followed by administration of a maturation signal in vivo. The invention provides for treatment of cancer through induction of anticancer immunity and/or immunity towards tumor associated blood vessels. | 2016-03-17 |
20160074490 | FORMULATION AND METHOD FOR PREPARING SPECIFIC T CELL, AND METHOD FOR PREPARING THE FORMULATION - The present invention provides a formulation and method for preparing specific T cells, and a method for fabricating the formulation is also disclosed. The formulation can induce specific T cell responses, and comprises at least a cell population of dendritic killer cells presenting specific antigens. In addition, the method mentioned above for preparing specific T cells comprises following steps. A T cell population is provided, and then a formulation of preparing specific T cells is mixing with the T cell population. After cultivating, the specific T cells are harvested. Furthermore, the method for fabricating the above formulation comprises the following steps. First, a cell population of dendritic killer cells is provided. A target sample is then provided, and a step of making the cell population of the dendritic killer cells is co-cultivated with the target sample. After co-cultivating, a cell population of dendritic killer cells presenting specific antigens is harvested. | 2016-03-17 |
20160074491 | METHODS AND COMPOSITIONS FOR INDUCING AN IMMUNE RESPONSE TO EGFRvIII - The present invention relates to methods of inducing a T-cell response against a EGFRvIII in a subject. These method comprise administering to a subject a composition which expresses at least one immunogenic polypeptide, the amino acid sequence of which comprise a plurality of EGFRvIII polypeptide sequences, the sequence of which each comprise EEKKGNYV (SEQ ID NO: 3), and/or administering the polypeptide itself. | 2016-03-17 |
20160074492 | Oral Vaccine For Borrelia - The present invention relates to vaccines for control of | 2016-03-17 |
20160074493 | IMMUNOGENIC COMPOSITIONS CONTAINING ESCHERICHIA COLI H7 FLAGELLA AND METHODS OF USE THEREOF - Immunogenic compositions containing | 2016-03-17 |
20160074494 | CANCER THERAPY - The present invention resides in the preparation of a medicament to aid in the treatment of cancer. According to the invention there is a whole cell | 2016-03-17 |
20160074495 | Inactivated Bacterial Cell Formulation - The invention relates to the use of lactic acid-producing bacteria to boost the immune system. | 2016-03-17 |
20160074496 | CLOSTRIDIUM DIFFICILE VACCINE AND METHODS OF USE - Embodiments of the present disclosure include vaccine compositions comprising a TcdB toxin or toxoid derived therefrom. The TcdB toxin may be derived from a hypervirulent strain of | 2016-03-17 |
20160074497 | STAPHYLOCOCCUS LIVE CELL VACCINES - protein A variants, defective in immunoglobulin binding, elicit protective immunity against staphylococcal disease. The present invention includes methods for preventing or ameliorating staphylococcal infections, particularly hospital acquired nosocomial infections. As such, the invention contemplates vaccines for use in both active and passive immunization embodiments. In certain embodiments the vaccine is an isolated recombinant staphylococcal bacteria that expresses a variant Protein A (SpA variant) comprising (a) at least one amino acid substitution that disrupts Fc binding and (b) at least a second amino acid substitution that disrupts VH3 binding variant in at least one of SpA A, B, C, D, and/or E domains. | 2016-03-17 |
20160074498 | COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF Ebp PILUS-RELATED DISEASES - The present invention relates to compositions comprising EbpA and methods of use thereof. Specifically, methods useful in the treatment and prevention of EbpA-associated infections. | 2016-03-17 |
20160074499 | ANTI-INFLAMMATORY, SKIN-REGENERATIVE, WHITENING, ANTIOXIDANT, OR WOUND-HEALING COMPOSITION CONTAINING CULTURE MEDIUM OF ADSC-T CELLS IN WHICH T-ANTIGEN IS INTRODUCED INTO ADIPOSE-DERIVED STEM CELL AS ACTIVE INGREDIENT - The present invention relates to an anti-inflammatory, skin-regenerative, whitening, antioxidant, or wound-healing composition containing a culture medium of adipose-derived stem cell-T (ADSC-T) cells as an active ingredient, in which T-antigen is introduced into an adipose-derived stem cell. The culture medium of ADSC-T cells, according to the present invention, has remarkable effects for treating or inhibiting inflammation by alleviating atopic dermatitis, which is an autoimmune disease, and inhibiting NF-κB activities through an increase of an Iκbα expression. Additionally, the culture medium, according to the present invention, exhibits: excellent skin regenerative effects by having effects of enhancing skin collagen elasticity and reducing wounds, in a collagen culture; excellent skin whitening effects by inhibiting tyrosinase activities and melanin production; and excellent anti-oxidation effects by inhibiting DPPH radical activities. Furthermore, the present invention has remarkable wound-healing effects by enhancing cell mobility of fibroblast, and is thus useful for anti-inflammation, skin-regeneration, whitening, anti-oxidation, or healing wounds. | 2016-03-17 |
20160074500 | INFECTIOUS DNA VACCINES AGAINST CHIKUNGUNYA VIRUS - Described herein are i-DNA™ vectors and vaccines and methods for using the same. The i-DNA™ generates live attenuated vaccines in eukaryotic cells in vitro or in vivo for pathogenic RNA viruses, particularly chikungunya virus (CHIKV). When iDNA is injected into the vaccine recipient, RNA of live attenuated virus is generated by in vivo transcription in the recipient's tissues. This initiates production of progeny attenuated viruses in the tissues of the vaccine recipient, as well as elicitation of an effective immune response protecting against wild-type, non-attenuated virus. | 2016-03-17 |
20160074501 | Flavivirus virus like particle - Provided is a virus like particle comprising one or more flavivirus structural proteins, and a composition or vaccine comprising thereof, its use in the prevention or treatment of flavivirus infection. The flavivirus structural protein contains at least one amino acid alteration in the envelope region. Examples of flavivirus contains dengue virus. | 2016-03-17 |
20160074502 | RECOMBINANT SUBUNIT DENGUE VIRUS VACCINE - The present invention provides dengue virus vaccines and immunogenic compositions for administration to human subjects. The vaccine compositions of the present invention comprise recombinantly produced monomeric and/or dimeric forms of truncated dengue virus envelope glycoprotein that, when formulated together with an adjuvant and a pharmaceutically acceptable carrier, induce balanced tetravalent immune responses. In preferred embodiments of the compositions described herein, the DEN4 protein component is a dimeric form of DEN4. The compositions are designed to be acceptable for use in the general population, including immunosuppressed, immunocompromised, and immunosenescent individuals. Also provided herein are methods of inducing a protective immune response in a human patient population by administering the compositions described herein to the patients. | 2016-03-17 |
20160074503 | Porcine Reproductive and Respiratory Syndrome Virus Compositions and Uses Thereof - Provided herein are embodiments relating to porcine reproductive and respiratory syndrome (PRRS) virus, compositions comprising the virus, and methods of using the virus. The virus may be used to immunize a mammal, including swine. Methods for generating an immune response against PRRS virus in swine by administering a composition comprising the virus are provided. | 2016-03-17 |
20160074504 | NANOEMULSION INFLUENZA VACCINE - The present invention relates to methods for inducing an immune response to influenza in a subject comprising administering a nanoemulsion vaccine composition comprising an influenza immunogen or protein. | 2016-03-17 |
20160074505 | Method and System for Targeting the Microbiome to Promote Health and Treat Allergic and Inflammatory Diseases - A method and system for targeting the microbiome to promote health involves exposing an expectant mother to a mixture of farm derived manure-containing soil to reduce the chances her baby will suffer allergies and autoimmune diseases. City dwelling expectant mothers are exposed to immunologic agents and allergens in a fashion (e.g., via exposure to farm animal manure-containing soils) that charges their immune system and that of their fetus(es) so that their babies, once born, are provided with immunity against a variety of autoimmune diseases, including allergies commonly and increasingly experienced in modern urban environments. | 2016-03-17 |
20160074506 | DELIVERY OF SELF-REPLICATING RNA USING BIODEGRADABLE POLYMER PARTICLES - Particle compositions comprising adsorbed RNA replicons as well as methods of making and using the same are described. | 2016-03-17 |
20160074507 | METHOD FOR PREPARING VIRAL PARTICLES WITH CYCLIC DINUCLEOTIDE AND USE OF SAID PARTICLES FOR INDUCING IMMUNE RESPONSE - The present invention relates to methods for preparing virus-like particles comprising immunogenic cyclic dinucleotides. | 2016-03-17 |
20160074508 | COMPOSITIONS FOR STIMULATION OF MAMMALIAN INNATE IMMUNE RESISTANCE TO PATHOGENS - Embodiments of the invention are directed to methods of treating, inhibiting or attenuating a microbial infection in an individual who has or is at risk for developing such an infection, comprising the step of administering an effective amount of a StIR composition to the individual. | 2016-03-17 |
20160074509 | METHODS AND COMPOSITIONS RELATED TO IMMUNOGENIC FIBRILS - Embodiments of the invention are directed to fibrillar adjuvants. Epitopes assembled into nanofibers by a short synthetic fibrillization domain elicited high antibody titers in the absence of any adjuvant. | 2016-03-17 |
20160074510 | METHOD AND DEVICE TO DELIVER ANTIFIBRINOLYTIC DRUGS TO IMPEDE TUMOR GROWTH AND INCREASE THE RADIO SENSITIVITY OF CANCEROUS TISSUE - Antifibrinolytic agents/drugs are applied to a cancerous area to impede tissue growth and increase the radio sensitivity of cancerous tissue. Various techniques are described for administering the antifibrinolytic agent. | 2016-03-17 |
20160074511 | RECOMBINANT SELF-ASSEMBLING PROTEIN COMPRISING TARGET-ORIENTED PEPTIDE AND USE THEREOF - The present invention relates to a recombinant self-assembled protein comprising a target-oriented peptide and a use thereof. The recombinant self-assembled protein according to the present invention, comprising a target-oriented peptide, does not require an additional process for providing target-orientedness, and is thus capable of delivering a desired drug to a target tissue or target cell without using additives, such as chemical binders or stabilizers; therefore, the protein can be used for photothermal therapy, drug delivery, imaging, or the like. In particular, according to the present invention, it is to possible to prepare gold-protein nanoparticle fusions in which uniform high-density gold nanoparticles having target-orientedness are bound to protein surfaces, without an additional process of surface stabilization or process for providing target-orientedness. Compared with conventional gold nanoparticles, the gold-protein nanoparticle fusions according to the present invention show structural stability against pH variation and concentration variation, and also have excellent target-orientedness; therefore, the fusions can bring a dramatic enhancement to the utilization of gold nanoparticles in photothermal therapy. | 2016-03-17 |
20160074512 | PROTON INDUCED BORON CAPTURE THERAPY - The present disclosure recites a method of treating biological tissues. The method includes using a proton beam includes irradiating a proton beam to a biological tissue containing a reactant. The reactant includes a first composite and a second composite. The first composite reacts with at least one proton from the proton beam and then releases at least one neutron inside the biological tissue. The second composite reacts with the at least one said neutron to release at least one α particle or γ rays, and said α particle or said γ rays to react with the biological tissue. | 2016-03-17 |
20160074513 | Long-Acting Semi-Solid Lipid Formulations - What is described is a semi-solid controlled release composition comprising a semi-solid lipid pharmaceutical active agent in a solution or a homogenous suspension, methods of using the composition for treating a disease, and methods of manufacturing the composition. | 2016-03-17 |
20160074514 | Lipids for Therapeutic Agent Delivery Formulations - The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes. | 2016-03-17 |
20160074515 | VISCOSITY-REDUCING EXCIPIENT COMPOUNDS FOR PROTEIN FORMULATIONS - The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions. | 2016-03-17 |
20160074516 | Ionically Crosslinked Polyelectrolytes as Underwater Adhesives as Controlled Release Vehicles - Underwater adhesive materials, methods of making the same, and methods of using the same are described. | 2016-03-17 |
20160074517 | AQUEOUS FORMULATIONS OF SPARINGLY WATER-SOLUBLE ACTIVE INGREDIENTS COMPRISING AS SOLUBILIZER A MIXTURE OF POLOXAMERS DIFFERING IN HYDROPHOBICITY - Use of a mixture | 2016-03-17 |
20160074518 | INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN THE PI OF WHICH IS BETWEEN 5.8 AND 8.5 AND A SUBSTITUTED CO-POLYAMINO ACID - A composition in the form of an injectable aqueous solution, the pH of which is between 6.0 and 8.0, including at least (a) a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5; and (b) a co-polyamino acid bearing carboxylate charges and substituted with hydrophobic radicals. In one embodiment, the compositions also include a prandial insulin and/or a gut hormone. | 2016-03-17 |
20160074519 | CROSSLINKED HYALURONIC ACID COMPOSITIONS - Crosslinked hyaluronic acid compositions are disclosed herein. More specifically, the hyaluronic acid is crosslinked with a biologically active compound selected from amino acids, amino esters, hydroxy acids, hydroxy esters, vitamins, stabilizers and mixtures thereof. The crosslinking is conveniently achieved by means of an extrusion process. | 2016-03-17 |
20160074520 | WOUND HEALING COMPOSITIONS COMPRISING BIOCOMPATIBLE CELLULOSE HYDROGEL MEMBRANES AND METHODS OF USE THEREOF - The present invention provides a wound healing composition comprising a biocompatible hydrogel membrane wherein the hydrogel membrane has one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The invention further provides methods of treating a wound in a subject in need thereof, comprising contacting the wound with a biocompatible cellulose hydrogel membrane of the invention. | 2016-03-17 |
20160074521 | PEPTIDE-MEDIATED INTRAVESICAL DELIVERY OF THERAPEUTIC AND DIAGNOSTIC AGENTS - The present invention relates to compositions comprising therapeutic and/or diagnostic anionic agents together with cationic peptides and their use in methods for delivering the anionic agents to bladder cells. | 2016-03-17 |
20160074522 | IMMUNITY INDUCER FOR SACCHARIDE ANTIGENS - The present invention provides an immunity inducer and an immunity inducing method using same. The immunity inducer has an immunopotentiation effect on any target oligosaccharide antigen, in particular oligosaccharide antigens included in mammal-derived glycoprotein N-linked sugar chains; is capable of providing a monoclonal antibody having high specificity to and affinity with target oligosaccharide antigens; and has as an effective component thereof a glycolipid including a target oligosaccharide antigen (R) and indicated by general formula (2), or a salt thereof. General formula (2): R—Z—Y—CH(NH—CO—(CH | 2016-03-17 |
20160074523 | PRODRUGS OF NAPROXEN AND DICLOFENAC - The present invention relates to a compound of formula (I): wherein R | 2016-03-17 |
20160074524 | A LARGE SCALE PROCESS FOR PREPARING POLY (GLUTAMYL-GLUTAMATE) CONJUGATES - Described herein are processes of making biocompatible water-soluble polymers conjugates. In particular, large scale processes of making poly(L-γ-glutamyl-glutamate) conjugates that can be useful for a variety of drug delivery applications are described herein. | 2016-03-17 |
20160074525 | NOVEL SINGLE CHEMICAL ENTITIES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES - In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at the 2′-position of the ribose rings and/or the terminal 3′- and/or 5′-positions of the oligonucleotide; 3) optionally, one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide. | 2016-03-17 |
20160074526 | SSTR-TARGETED CONJUGATES ENCAPSULATED IN PARTICLES AND FORMULATIONS THEREOF - Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases. | 2016-03-17 |
20160074527 | PYRROLOBENZODIAZEPINES AND ANTIBODY DISULFIDE CONJUGATES THEREOF - A compound of formula I: | 2016-03-17 |
20160074528 | ANTHRACYCLINE DISULFIDE INTERMEDIATES, ANTIBODY-DRUG CONJUGATES AND METHODS - The invention provides antibody-drug conjugates comprising an antibody conjugated to an anthracycline drug moiety via a disulfide linker, anthracycline disulfide intermediates, and methods of using the antibody-drug conjugates. | 2016-03-17 |
20160074529 | ANTI-WALL TEICHOIC ANTIBODIES AND CONJUGATES - The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same. | 2016-03-17 |
20160074530 | Nanoparticles for Drug Delivery Comprising Albumin Having a Polymer Chain Coupled Thereto - The invention provides a dispersion of assemblies. The assemblies comprise an albumin derivative comprising albumin having a polymer chain coupled thereto, wherein the assemblies comprise a core comprising the polymer chains and a shell comprising the albumin. A process for making the dispersion and methods of using the dispersion are also described. | 2016-03-17 |
20160074531 | METHODS AND COMPOSITIONS FOR ATTENUATING GENE THERAPY ANTI-VIRAL TRANSFER VECTOR IMMUNE RESPONSES - Provided herein are methods and related compositions for administering viral transfer vectors and antigen-presenting cell targeted immunosuppressants. | 2016-03-17 |
20160074532 | METHODS AND COMPOSITIONS FOR ATTENUATING GENE EDITING ANTI-VIRAL TRANSFER VECTOR IMMUNE RESPONSES - Provided herein are methods and related compositions for administering viral transfer vectors and antigen-presenting cell targeted immunosuppressants. | 2016-03-17 |
20160074533 | VECTOR ENCODING THERAPEUTIC POLYPEPTIDE AND SAFETY ELEMENTS TO CLEAR TRANSDUCED CELLS - A composition comprising: a stably integrating delivery vector; a modified mammalian thymidylate kinase (tmpk) activator polynucleotide wherein the modified mammalian tmpk polynucleotide encodes a modified mammalian tmpk polypeptide that increases phosphorylation of a prodrug relative to phosphorylation of the prodrug by wild-type mammalian tmpk polypeptide to a drug; and/or a targeting polynucleotide encoding a cell surface polypeptide that selectively binds a toxic binding agent. The disclosure also relates to use of these compositions in methods of treatment of diseases such as Fabry disease. | 2016-03-17 |
20160074534 | GENE THERAPY COMPOSITION FOR USE IN DIABETES TREATMENT - New gene therapy constructions and compositions are the subject of present invention. The gene therapy compositions consist in adeno-associated vectors which jointly express insulin (Ins) and glucokinase (Gck) genes. The new gene therapy constructions are useful for treatment of diabetes either in dogs or human beings. | 2016-03-17 |
20160074535 | COMPOSITIONS AND METHODS FOR THE EXPRESSION OF CRISPR GUIDE RNAS USING THE H1 PROMOTER - The presently disclosed subject matter provides compositions and methods for the expression of CRISPR guide RNAs using the H1 promoter. In particular, compositions and methods are provided for the use of the H1 promoter to express CRISPR guide RNA (gRNA) with altered specificity of the 5′ nucleotide, as well as use of the H1 promoter sequence as a bidirectional promoter to express Cas9 nuclease and the gRNA simultaneously. Compositions and methods are also provided for the expression and regulation of gRNA expression in vivo through the use of RNA ribozymes and regulatable aptazymes. | 2016-03-17 |
20160074536 | SYSTEMS AND METHODS FOR INTRA-TARGET MICRODOSING (ITM) - Systems and methods for intra-target microdosing are disclosed. According to an aspect, a method for intra-target microdosing includes administering a microdose of drug into target tissue within a subject. The method also includes measuring efficacy of the administered drug to the target tissue. | 2016-03-17 |
20160074537 | Immunoconjugates for the Treatment of Tumours - A pharmaceutical composition comprising a conjugate of a cytokine and a tumor targeting moiety (TTM) and a pharmaceutically acceptable excipient, wherein the cytokine is present in an amount which does not induce a negative feedback mechanism. | 2016-03-17 |
20160074538 | NANOPARTICLES FOR MAGNETIC RESONANCE IMAGING APPLICATIONS - A method of preparing a coated nanoparticle can include decomposing a compound to produce a nanoparticle, oxidizing the nanoparticle to produce an oxidized nanoparticle, and coating the oxidized nanoparticle with a zwitterionic ligand to produce the coated nanoparticle. The coated nanoparticle or the nanoparticle can be used in magnetic resonance imaging. | 2016-03-17 |
20160074539 | TARGETING CONSTRUCTS - Gas-filled microvesicles associated with a polypeptide comprising a sequence of amino acids, said sequence exhibiting binding affinity for selectins, particularly p-selectin. The gas-filled microvesicles can be used in ultrasound imaging. | 2016-03-17 |
20160074540 | METAL COMPLEXES AND THEIR FLUORINATION - A method of labelling biological molecules with | 2016-03-17 |
20160074541 | Prosthetic Compounds for Labeling Internalizing Biomolecules - Prosthetic compounds are disclosed that are effective for radiolabeling biomolecules with 18F. Representative biomolecules include antibodies (e.g., monoclonal antibodies (mAbs) and nanobodies (sdAbs)), antibody fragments, and peptides that may have an affinity for particular types of cells, such as cancer cells. The prosthetic compounds effectively address the art-recognized difficulties associated with the retention of radioactivity within the targeted cells, due to internalization of the biomolecule, followed by proteolytic degradation. Representative prosthetic compounds include (i) a succinimidyloxycarbonyl moiety, (ii) a radioactive moiety bearing 18F, and (iii) a charged moiety, i.e., a moiety that is charged under the physiological conditions of the internal cell environment. | 2016-03-17 |
20160074542 | SYSTEMS AND METHODS FOR CLEANING AND DISINFECTING ALLOGRAFT MATERIAL - There is disclosed a system for cleaning and disinfecting allograft material. In an embodiment, the system includes a sterile bag and a motorized paddle blender. The sterile bag having an outer wall configured to withstand blending forces, at least one paddle contact section, and an allograft retaining section separate from the at least one paddle contact section. The motorized paddle blender having at least one paddle configured to apply blending forces on the sterile bag on the at least one paddle contact area, a motorized portion to actuate the at least one paddle, and a door component configured to hold the sterile bag adjacent the at least one paddle. The at least one paddle and the allograft retaining section are configured to prevent the paddle from contacting the allograft material when the blending forces are applied on the sterile bag on the at least one paddle contact area. | 2016-03-17 |
20160074543 | SANITIZED ANIMAL BEDDING MATERIAL AND PROCESS - The present invention provides compositions and methods for sanitization or sterilization of, or reduction or elimination of microbes from, PFR material, in particular material for use as an animal bedding. In another aspect, the invention provides sanitized or sterilized material, and especially animal bedding material, prepared using the described compositions and methods. | 2016-03-17 |
20160074544 | WASTE REMEDIATION - A system including a steam generation system and a chamber. The steam generation system includes a complex and the steam generation system is configured to receive water, concentrate electromagnetic (EM) radiation received from an EM radiation source, apply the EM radiation to the complex, where the complex absorbs the EM radiation to generate heat, and transform, using the heat generated by the complex, the water to steam. The chamber is configured to receive the steam and an object, wherein the object is of medical waste, medical equipment, fabric, and fecal matter. | 2016-03-17 |
20160074545 | STERILIZATION APPARATUS FOR PORTABLE ELECTRONIC DEVICE - A sterilization apparatus for a portable electronic device may include: a case having an opening receiving a portable electronic device; an ultraviolet (UV) irradiation unit arranged in the case, and configured to sterilize the portable electronic device by irradiating UV light onto the portable electronic device; a door connected to the case for opening and closing the opening of the case; and a display unit connected to the portable electronic device, and configured to display an image outputted from the portable electronic device. | 2016-03-17 |
20160074546 | Mobile Ultraviolet Sterilization Systems and Methods - Sterilization units and systems and related assemblies, devices, and methods are disclosed. The sterilization units may be mobile and used in a variety of locations. The sterilization units and systems use germicidal ultraviolet-C light to kill or render non-viable bacteria and viruses. The various sterilization units and systems disclosed herein may have improved ultraviolet light distribution and/or improved ability to direct and focus the ultraviolet light in a desired area. The sterilization units and systems may optionally be made of non-magnetic materials such that the sterilization units and systems may be used in the vicinity of MRI equipment without causing complications or damage to the MRI equipment. | 2016-03-17 |
20160074547 | Ultraviolet Illuminator for Footwear Treatment - An ultraviolet (UV) footwear illuminator for footwear treatment is disclosed. In one embodiment, the UV footwear illuminator includes an insert adapted for placement in an article of footwear. At least one UV radiation source is located in the insert and is configured to emit UV radiation in the footwear through a transparent window region formed in the insert. A control unit is configured to control at least one predetermined UV radiation characteristics associated with the radiation emitted from each UV radiation source. A power supply is configured to power each UV radiation source and the control unit. | 2016-03-17 |
20160074548 | Diffusive Light Illuminator - A diffusive illuminator is provided. The diffusive illuminator includes a set of light sources and a light guiding structure including a plurality of layers. At least some of the layers can be formed of a fluoropolymer and at least one layer can be formed of a transparent fluid. The light guiding structure also includes an emission surface through which diffused light exits. The light guiding structure can further include diffusive elements associated with at least one of the plurality of layers. Each diffusive element can diffuse the light to within forty percent of Lambertian distribution. The diffusive elements can be arranged based on a desired uniformity of the diffused light at a target distance corresponding to a surface to be illuminated. The diffusive illuminator can emit ultraviolet light, and can be implemented as part of a disinfection system. | 2016-03-17 |
20160074549 | ACTIVATED DISINFECTANT HYDROGEN PEROXIDE COMPOSITIONS - Activated hydrogen peroxide disinfecting compositions are provided especially for low-foaming applications. A concentrate for dilution by an end-user is provided, which includes a hydrogen peroxide source, a non-surfactant organic sulfonic acid or salt thereof, a non-ionic surfactant, and an optional organic acid. Also provided is a ready-to-use hydrogen peroxide, disinfectant solution including a biocidal amount of hydrogen peroxide, a non-surfactant organic sulfonic acid or salt thereof, a non-ionic surfactant, water as solvent and an optional organic acid. An end-user can disinfect a surface of microorganisms by contacting the surface with the disinfecting composition for an amount of time effective to kill a majority of the microbes located on the surface. | 2016-03-17 |
20160074550 | ODOR ADSORBENT - Described is an odor adsorbent, in particular for use in absorptive hygiene articles, comprising: a) peroxomonosulfuric acid and/or salts thereof and also b) zeolite. Also described are water-absorbing polymeric particles wherein the particles are laden with a mixture comprising a) peroxomonosulfuric acid and/or salts thereof and also b) zeolite, and wherein the water-absorbing polymeric particles preferably comprise a crosslinked polymer based on partially neutralized acrylic acid, and more particularly are surface-postcrosslinked. | 2016-03-17 |
20160074551 | DISPOSABLE ABSORBENT PAD - A menstruation pad member adapted to be used in and out of water is provided. The pad member may provide a plurality of barriers, including a liquid-absorbent core sheet and a liquid-impermeable dressing sheet may be bonded together and sandwiched between a paper backing and an outline structural paper. The paper backing and the structural paper may be removed in use, wherein a user seals the liquid-impermeable dressing sheet about, circumscribing the vagina, with the liquid-absorbent core sheet upward facing, positioned within the vagina. | 2016-03-17 |
20160074552 | A DISCONTINUOUS HYDROCOLLOID ARTICLE - A discontinuous hydrocolloid article is disclosed that provides for a high rate of water absorption and a high rate of water vapor transmission. Also, disclosed is a method of making a discontinuous hydrocolloid article. In one embodiment, the discontinuous hydrocolloid article comprises a plurality of cross-linked polymer strands comprising a hydrophobic polymer and a hydrocolloid dispersed throughout the hydrophobic polymer and a plurality of joining strands. Each polymer strand repeatedly contacts an adjacent joining strand at bond regions. | 2016-03-17 |
20160074553 | DRESSING FOR COMPROMISED WOUND HEALING - The invention relates to a bioactive medical product, or dressing, characterised in that it comprises at least an inner layer formed by a hydrogel and an outer layer formed by a biodegradable and bioabsorbable polyurethane, said inner layer being impregnated with an N-terminal peptide of 20 amino acids of pro-adrenomedullin and the outer layer being impregnated with nanoparticles of bemiparin encapsulated in a biodegradable copolymer or polymer. The active components can be dosed in a sequential and controlled manner with this composition. The invention also relates to a method for producing the two-layer dressing and to the use thereof in medicine, said dressing being specially designed to treat and promote the healing of wounds, such as compromised wounds and ulcers, particularly in patients with diabetes and reduced blood supply. | 2016-03-17 |
20160074554 | EMULSIONS OR MICROEMULSIONS FOR USE IN ENDOSCOPIC MUCOSAL RESECTIONING AND/OR ENDOSCOPIC SUBMUCOSAL DISSECTION - The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection. | 2016-03-17 |
20160074555 | Antipathogenic Compositions - Compositions useful as bone fillers or dental composites are provided which may include a sterilizing agent. | 2016-03-17 |
20160074556 | SIMPLE COACERVATES AND METHODS OF USE THEREOF - Described herein is the synthesis of adhesive from simple adhesive coacervates and their uses thereof. The adhesives are produced by (a) preparing a solution comprising (1) a polyelectrolyte, wherein the polyelectrolyte comprises a polyanion or polycation but not a combination thereof, the polyeletrolyte comprises at least one crosslinking group, and (2) a sufficient amount of a complimentary counterion to produce a simple adhesive coacervate; and (b) crosslinking the simple adhesive coacervate to produce the adhesive. The adhesives have numerous medical and non-medical applications. | 2016-03-17 |
20160074557 | COMPOSITIONS AND METHODS FOR MODIFYING IN VIVO CALCIFICATION OF HYDROGELS - Provided herein according to some embodiments of the invention are methods of inhibiting or preventing calcification of hydrogels. Such methods may include combining the hydrogel with a buffer solution having a pH lower than 7.4; forming hydrogel by crosslinking alginate in a solution comprising a bisphosphonate compound; and/or forming hydrogel by crosslinking polyanionic polymer with a polyvalent cation that is not Ca | 2016-03-17 |
20160074558 | DEVICES, SYSTEMS, AND METHODS FOR THE FABRICATION OF TISSUE - Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry. | 2016-03-17 |
20160074559 | ANTIMICROBIAL WRAPS FOR MEDICAL IMPLANTS - Biodegradable antimicrobial films are provided that are solid at room temperature and substantially liquefy in situ after implantation into a mammal, such as a human patient. Methods of using the films to cover a medical device, such as a breast implant, prior to insertion into a subject are also provided. | 2016-03-17 |
20160074560 | ANTIMICROBIAL CATHETERS - Antimicrobial catheters and medical devices are provided. In some aspects, a low durometer aliphatic polyether polyurethane may be impregnated with a first antimicrobial agent (e.g., minocycline and rifampin) and coated with a second antimicrobial agent (e.g., chlorhexidine, gendine, or gardine). The antimicrobial catheters may display improved flexibility and resistance to kinking. Methods of producing the antimicrobial catheters are also provided. | 2016-03-17 |
20160074562 | DRUG ELUTING STENT WITH A BIODEGRADABLE RELEASE LAYER ATTACHED WITH ELECTRO-GRAFTED PRIMER COATING - The present invention provides a drug eluting stent including a metallic stent framework, an electro-grafted primer coating disposed on the stent framework; and a biodegradable polymer coating hosting a drug disposed on the electro-grafted primer coating and a method of manufacturing said biodegradable drug eluting stent. | 2016-03-17 |
20160074563 | MEDICAL DEVICES WITH REDUCED THROMBOGENICITY - A plasma-activated coating (PAC) process covalently binds enzymes in their bioactive state, has low thrombogenicity and can be robustly applied to medical devices, resisting delamination when deployed in vivo. Applying this process to attachment of proteins such as enzymes that inhibit thrombosis and anticoagulants such as heparin or heparin fragments, one can produce medical devices and other materials for use in vascular applications having a number of benefits including covalent attachment, not requiring intermediate linkers or chemistry; substrate independent works on polymers, metals, ceramics, 3D shapes like stents, valves, etc.; bioactivity is retained; surface may retain greater bioactivity over time in vivo; Simultaneously supports endothelialisation; can be stored for long periods, following freeze drying, and retains effectiveness when rehydrated and; surface is able to bind many fibrinolytic enzymes such as streptokinase, urokinase, tPA, plasmin). | 2016-03-17 |
20160074564 | WOUND MANAGEMENT - A method and apparatus are disclosed for delivering at least one agent to a wound site. The method includes the steps of providing a delivery tube having an outlet at a wound site, covering the wound site with a drape and introducing agent at an agent inlet port of the delivery tube. The agent passes along the delivery tube through the drape to the wound site. The agent can be a wide variety or mixture of fluids such as but not limited to pain relief medicament, anti-biotics, saline solution and/or hydrating fluid. | 2016-03-17 |
20160074565 | PORTABLE HEMODIALYSIS MACHINE AND DISPOSABLE CARTRIDGE WITH FLOW SENSOR - A portable hemodialysis system is provided including a disposable cartridge and a reused dialysis machine. The disposable cartridge includes a dialysate flow path and a blood flow path which flow in opposite directions through a dialyzer. The disposable cartridge further includes a filter for removing waste products from the dialysate as well as one or more flow sensors for measuring the flow of dialysate in the dialysate flow path. The preferred flow sensor includes a rotatable spoked wheel in the dialysate flow path which is rotated by the flow of dialysate. The spoked wheel includes one or more magnets which are rotated with the rotation of the spoked wheel. The flow sensor further includes a magnetic field sensor in the reused dialysis machine which is connected to a processor for monitoring the rotation of the spoked wheel to determine flow of fluid in the dialysate flow path. | 2016-03-17 |
20160074566 | PORTABLE HEMODIALYSIS MACHINE AND DISPOSABLE CARTRIDGE WITH DIALYSIS RESERVOIR LEVEL SENSOR - A portable hemodialysis system is provided including a disposable cartridge and a reused dialysis machine. The disposable cartridge includes a dialysate flow path and a blood flow path which flow in opposite directions through a dialyzer. The disposable cartridge includes a filter for removing waste products from the dialysate. The reused dialysis machine possesses a reservoir for dialysate, various sensors including a reservoir level sensor assembly, and a processor connected to the various sensors for controlling and monitoring hemodialysis treatment. The reservoir level sensor assembly includes a vertically extending electrode array for transmitting electrical signals to the processor detecting whether the reservoir possesses sufficient dialysate for therapy, and for detecting whether there is a fault condition during therapy such as a loss of dialysate in the reservoir or an increase in fluid in the reservoir which may indicate a failure in the dialysis membrane. | 2016-03-17 |
20160074567 | PORTABLE HEMODIALYSIS ASSEMBLY WITH AMMONIA SENSOR - A portable hemodialysis system is provided including a disposable cartridge and a reused dialysis machine. The disposable cartridge includes a dialysate flow path and a blood flow path which flow in opposite directions through a dialyzer. The disposable cartridge includes a filter for removing waste products from the dialysate, and pressure and fluid flow sensors for measuring the pressure and fluid flow in the dialysate flow path and blood flow path. Preferably, the filter has a vapor membrane for releasing gases including ammonia, but not liquids such as the dialysate. The reused dialysis machine possesses a reservoir for dialysate, an ammonia sensor adjacent to the vapor membrane, a level sensor, a blood leak sensor, a venous blood line pressure sensor, a venous blood line bubble detector, pump motors, and a processor connected to the motors and sensors for controlling and monitoring hemodialysis treatment. | 2016-03-17 |
20160074568 | PORTABLE HEMODIALYSIS MACHINE AND DISPOSABLE CARTRIDGE WITH BLOOD LEAK SENSOR - A portable hemodialysis system is provided including a disposable cartridge and a reused dialysis machine. The disposable cartridge includes a dialysate flow path and a blood flow path which flow in opposite directions through a dialyzer. The disposable cartridge includes a filter for removing waste products from the dialysate. The reused dialysis machine possesses a reservoir for dialysate, various sensors including a blood leak sensor assembly, and a processor connected to the various sensors for controlling and monitoring hemodialysis treatment. The blood leak sensor assembly includes a light source for emitting light through the dialysate flow path and a light sensor for receiving light having passed through the dialysate flow path. The processor is connected to the light source for determining whether blood has leaked from the blood flow path into the dialysate flow path. Preferably, the light source emits light having two peak wavelengths. | 2016-03-17 |
20160074569 | Polymeric Whole Blood Hollow Fiber Membrane Filter Medium and Use Thereof For Separating Blood Plasma/Serum From Whole Blood - A whole blood hollow fiber membrane filter medium is made of a polymeric material having pores of a pore size that ensures permeability to blood plasma or serum but retains blood cells. The whole blood hollow fiber membrane filter medium is used for filtering a whole blood sample so that blood plasma or serum passes through the whole blood hollow fiber membrane filter medium and blood cells are retained. The obtained blood plasma shows no hemolysis. | 2016-03-17 |
20160074570 | BLOOD PURIFYING FILTER AND BLOOD PURIFYING APPARATUS - Provided are a blood purifying filter and a blood purifying apparatus having the same. The blood purifying filter includes a plasma separation filter separating plasma from blood, a hemodialysis filter configured in parallel with the plasma separation filter to remove toxins and waste products from blood, a housing providing installation space for the plasma separation filter and the hemodialysis filter, and plasma inlet and outlet ports provided in the housing. The housing further includes a wall, a lower cap and an upper cap which are coupled to the plasma separation filter and the hemodialysis filter. | 2016-03-17 |
20160074571 | CONTROL UNIT AND METHOD FOR DETERMINING THE PRESSURE IN A BLOOD VESSEL, IN PARTICULAR IN AN ARTERIOVENOUS FISTULA - The invention relates to a control unit ( | 2016-03-17 |
20160074572 | Needle Dispensing and Storing Apparatus for Medicament Delivery Device - A flip-open multi-pack assembly is provided which can contain a plurality of new pen needles, such as through the provision of a rectangular or tube-shaped shaped, hinged shell housing, wherein new pen needles can be stored in a plurality of user accessible openings each having a sterility barrier formed, for example, by covers that cover the non-patient end of the openings in which the new pen needles are contained. Used pen needles can be returned and stored in openings accessible by rotatably opening the shell housing. One or more of the openings within first and second opposite ends of the housing shell can be provided with a slidable internal holder within the device and are configured to releasably secure the inner shield of the new pen needle, and to then be pulled forward when the new pen needle is removed and lock at a forward position, and thereby create an interior space, accessible from an opposite end when the hinged housing is opened, for a used pen needle to be inserted and stored. | 2016-03-17 |
20160074573 | SYSTEM AND METHOD THAT MATCHES DELAYED INFUSION AUTO-PROGRAMS WITHMANUALLY ENTERED INFUSION PROGRAMS AND ANALYZES DIFFERENCES THEREIN - A system and method that identifies delayed infusion programs at an infusion pump or with a first computer and an infusion pump. The first computer receives an infusion auto-program from a remote source, transmits the infusion auto-program to the infusion pump, and sends a stale auto-program to the infusion pump. The infusion pump receives a manual infusion program, saves and executes the manual infusion program, and compares the stale auto-program to the manual infusion program to identify potential matches between the stale auto-program and the manual infusion program. The infusion pump evaluates the potential matches and determines if the potential matches are within a predefined tolerance, continues to execute the at least one manual infusion program on the infusion pump if the potential matches are within the predefined tolerance, and remotely saves differences in the manual infusion program and the at stale auto-program in a remote server for later analysis. | 2016-03-17 |
20160074574 | ROTATABLE ELECTRICAL CONNECTORS - A rotatable electrical connector can include a base housing having a bottom surface, a top housing that is rotatably engaged with the base housing, and a plurality of contact pads that are arranged radially within the base housing. The contact pads each have a top surface and a bottom surface. A plurality of signal pins are individually associated with the plurality of contact pads; and each of the signal pins correspondingly project outwardly from the bottom surface of an associated contact pad and outwardly from the bottom surface of the base housing. A center ground pad, having a top surface and a bottom surface, is provided within the base housing. A ground pin projects outwardly from the bottom surface of the center ground pad and outwardly from the bottom surface of the base housing. A plurality of conductors is arranged radially within the top housing. The conductors individually correspond to the plurality of contact pads within the base housing. Each of the conductors has (i) a bottom surface that is capable of being in rotatable contact with the top surface of each of the contact pads and (ii) a top surface that projects outwardly from the top housing. A ground conductor is centrally located within the top housing and is surrounded by the plurality of conductors. The ground conductor has a bottom surface that is in rotatable contact with the top surface of the center ground pad in the base housing, and a top surface that projects outwardly from the top housing. | 2016-03-17 |
20160074575 | BOLUS DRUG DELIVERY DEVICE - A supplemental pain medication device may be placed in parallel with a basal rate controller for providing a temporary increased level of pain medication to a patient on demand. a trigger of the supplemental pain medication device must be initially depressed in order to allow fluid to flow through the device so that an upper body of the device which is attached to a plunger may slide into a lower body which is attached to a reservoir. When the upper body is slid into the lower body, the plunger also slides into the reservoir to pump fluidic pain medication out of the device. | 2016-03-17 |
20160074576 | PORTABLE PUMP FOR INTRAVENOUS FLUIDS - A device includes at least one housing, a first input line operatively connected to a fluid source that is external to the at least one housing, and a second input line operatively connected to the fluid source. The device further includes a first fluid reservoir operatively connected to the first input line and a second fluid reservoir operatively connected to the second input line. An output line is operatively connected to the first fluid reservoir and the second fluid reservoir. An actuator is configured to facilitate a flow of fluid from the fluid source, through the first input line and second input line, and through the first fluid reservoir and second fluid reservoir. Each of the first and second input lines remains operatively connected to the fluid source during operation of the actuator. | 2016-03-17 |
20160074577 | FLUID DISPENSING DEVICE WITH A FLOW DETECTOR - A portable therapeutic fluid delivery device with a flow detector comprising a heating element and two temperature sensors is presented. Upon activation of the heating element, a flow condition of the fluid inside the delivery tube is determined based on a signal provided by the temperature sensors. A temperature gradient within the therapeutic fluid is detected. The determined flow condition can be one of: air bubbles within the delivery tube, occlusion within the delivery tube, or leakage within the delivery tube. The device can have two parts, for example, a reusable part and a disposable part. Upon pairing of these parts, the heating element and the temperature sensors touch the delivery tube. | 2016-03-17 |
20160074578 | MINIATURE PORTABLE MULTIFUNCTIONAL INFUSION DEVICE - A miniature portable multifunctional infusion device includes a liquid bottle ( | 2016-03-17 |
20160074579 | ADDITION TO A MEDICAL APPLICATOR - The presently disclosed subject matter relates to an addition to a medical applicator in general and in particular to an addition to a medical applicator for applying on a surface a curable liquid substance having multi components. | 2016-03-17 |
20160074580 | Attachment Device For Medical Fluid Container - An attachment device for connecting a fluid path set to a medical container includes a body having a pointed distal end configured for puncturing a membrane of the medical container and a proximal end configured for connecting to the fluid path set. The attachment device further includes a fluid channel extending along a longitudinal axis of the body between the distal end and the proximal end. The fluid channel is configured for delivering a medical fluid between the medical container and the fluid path set. At least one deflectable retaining element projects from the body of the attachment device between the distal end and the proximal end. The at least one retaining element is configured from non-removably retaining the attachment device with the medical container after the attachment device is connected to the medical container. | 2016-03-17 |
20160074581 | Modulated Drug Delivery - A method of delivering a therapeutic and/or diagnostic agent to tissue is provided including the steps of inserting a catheter into a bodily cavity, the catheter having a proximal balloon and a distal balloon, inflating the proximal and distal balloons to create a chamber between the proximal and distal balloons, delivering the therapeutic and/or diagnostic agent to the chamber, measuring fluid pressure in the chamber, measuring at least one fluid dynamic characteristic of a subject, and adjusting the delivery of the therapeutic and/or diagnostic agent based at least in part on the measured volumetric pressure in the chamber and the at least one fluid dynamic characteristic of the subject. | 2016-03-17 |
20160074582 | METHOD OF OPERATING A CONTROL DEVICE FOR CONTROLLING AN INFUSION DEVICE - Method of operating a control device for controlling an infusion device A method of operating a control device ( | 2016-03-17 |
20160074583 | METHODS AND SYSTEMS FOR PRESENTING A COMBINATION TREATMENT - Methods, computer program products, and systems are described that include accepting an indication of a schedule for administration of a bioactive agent to an individual and presenting an indication of an artificial sensory experience at least partly based on the accepting an indication of the schedule for administration of the bioactive agent to the individual. | 2016-03-17 |