12th week of 2009 patent applcation highlights part 50 |
Patent application number | Title | Published |
20090075815 | Fine Tetrahedral Palladium Particle and Process for Producing Fine Metallic Particle - An object of the present invention is to provide tetrahedral fine palladium particles having a high degree of shape selectivity, and a process for producing fine metal particles. | 2009-03-19 |
20090075816 | IMAGE PROCESSING METHOD AND IMAGE PROCESSING APPARATUS - To provide an image processing method including at least one of recording an image onto a thermoreversible recording medium in which transparency or color tone reversibly changes depending upon temperature, by applying a laser beam with the use of a CO | 2009-03-19 |
20090075817 | THERMOSENSITIVE RECORDING MATERIAL - A thermosensitive recording material including a support, a thermosensitive recording layer composed mainly of a leuco dye and a developer, provided on one surface of the support, and a back layer provided on the other surface of the support, wherein the back layer contains an isobutylene-maleic anhydride copolymer ammonium salt, and at least one of an aziridine compound, and a cross-linked product of the isobutylene-maleic anhydride copolymer ammonium salt and the aziridine compound. | 2009-03-19 |
20090075818 | Nanosilver for preservation and treatment of diseases in agriculture field. - A nano silver active material disclosed for use in agriculture. The active material prevents and treats major diseases in agricultural field. | 2009-03-19 |
20090075819 | Indanyl- and Tetrahydronaphtyl-amino-thiourea Compounds for Combating Animal Pests - The present invention relates to Indanyl- and Tetrahydronaphtyl-amino-thiourea compounds of formula I | 2009-03-19 |
20090075820 | Buffer System for Swimming Pools and Related Structures - The specification discloses water treatments for reducing the rate of growth of algae in water bodies such as swimming pools including the steps of providing a volume of water within a man made vessel having a pH value; and dissolving an algaecidal buffer into the volume of water in an amount sufficient to reduce the rate of growth of algae in the water, wherein the algaecidal buffer comprises a borate salt which when dissolved in the water buffers the pH value of the water to a value in a range from about 6.5 to about 8.8. | 2009-03-19 |
20090075821 | PLANT GROWTH REGULATOR AND A METHOD OF PRODUCIDNG THE REGULATOR - A plant growth regulator and a method for preparation thereof are provided; the plant growth regulaor comprises cinnamic acid as an active component, wherein cinnamic acid is dissolved or dispersed in an aqueous medium in high concentrations. The regulator prevents useless growth of young plants such as seedlings or nursery plants, and useless growth of potted plants (Bonsai); namely it is effective for dwarfing a plant; it can improve the quality of gardening plants and horticultural or agricultural yields. Since cinnamic acid is a naturally occurring substance, the plant growth regulator comprising the acid has high concern for environment and no problems in safety and health of human bodies. | 2009-03-19 |
20090075822 | Method of Altering the Alkaloid Composition in Poppy Plants - The method of altering the alkaloid composition of a poppy plant comprising the step of applying an effective amount of acylcyclohexanedione compound or agriculturally acceptable salt thereof to said poppy plant or locus thereof. Further, the present invention also provides the method of altering the alkaloid composition of a poppy plant comprising the step of applying an effective amount of methyl jasmonate or agriculturally acceptable salt thereof to said poppy plant or locus thereof. | 2009-03-19 |
20090075823 | PROCESS FOR PREPARING PYRIDINAMINES AND NOVEL POLYMORPHS THEREOF - The present invention relates to an improved process for the synthesis and purification of 3-chloro-N-(3-chloro-5-tri-fluoromethyl-2-pyridyl)-a,a,a-trifluoro-2,6-dinitro-p-toluidine (fluazinam) and other pyridinamines, which implements methyl isobutyl ketone (MIBK) as the reaction solvent. The process of the invention overcomes the drawbacks of prior art methods, by reducing the side reactions such as hydrolysis, eliminating the need for difficult and labor-intensive purification methods, and providing pure products in higher yields. The present invention relates to novel crystalline polymorphic forms fluazinam, and to mixtures of the polymorphs. The present invention also provides methods for preparing the novel polymorphs, as well as pharmaceutical compositions comprising same, and methods of using the polymorphs as pesticidal agents for combating noxious living organisms on agricultural and horticultural crops. | 2009-03-19 |
20090075824 | Laser Ablation Target and Method of Manufacturing the Same - To provide an RE-based oxide superconducting sintered body that can be used as a target applicable to a laser ablation method without bonding it to a backing plate, and a manufacturing method of the same. Each kind of powder or solution is prepared, and when a composition formula of an RE-based oxide superconductor is expressed by REaBabCucOx, raw materials are weighed and mixed so as to satisfy a+b+c=6, 0.95 | 2009-03-19 |
20090075825 | SYSTEMS, METHODS, AND APPARATUS FOR CONTROLLING THE ELEMENTS OF SUPERCONDUCTING PROCESSORS - A computer system employs a network that between a data programming system and one or more superconducting programmable devices of a superconducting processor chip. Routers on the network, such as first-, second- and third-stage routers direct communications with the superconducting programmable devices. A superconducting memory register may load data signals received from a first-stage router into corresponding superconducting programmable devices. The system may employ additional superconducting chips, first-, second- or third-stage routers. | 2009-03-19 |
20090075826 | Methods and apparatuses for sorting objects in forensic DNA analysis and medical diagnostics - The present invention relates to an apparatus and method of sorting objects and identifying the objects in a forensics sample, including using holographic optical trapping to sort objects from contaminants, and performing (single cell) PCR-based STR analysis on the objects to determine their identification. In addition, the chip used as a support for sorting the objects can also be used for performing single cell PCR-based STR analysis. In another embodiment, a microfluidics chip is used to stream the sample and sort the objects, before single cell PCR-based STR analysis is performed. The chip used for sorting utilizing HOT in the absence or presence of microfluidic streaming and sorting can also be the same as that used for the single cell PCR-based STR analysis. | 2009-03-19 |
20090075827 | DIAGNOSTIC METHODS AND AGENTS - The present invention relates generally to a method and agents for profiling or stratifying an individual or group of individuals with respect to a neurological, psychiatric or psychological condition, phenotype or state, including a sub-threshold neurological, psychiatric or psychological condition, phenotype or state. More particularly, the present invention utilizes genetic means to profile or stratify individuals with respect to a neurological, psychiatric or psychological condition, phenotype or state. The present invention enables the identification of individuals at risk of these disorders thus affording the opportunity for early intervention. In addition, the subject invention allows the prediction of drug or other treatment response and adverse reactions. | 2009-03-19 |
20090075828 | INTEGRATED PROTEIN CHIP ASSAY - The present invention relates to novel methodologies for performing multiplexed assays with high precision and sensitivity. In particular, the present invention relates to improving assay sensitivity and precision by combining the normalization of multiplexed assay data using an internal standard with scattered application of samples and standards replicates throughout sample wells on a slide or set of slides as well as scattered replicates of arrayed probes in a single well. These compositions and methods can be used to perform multiplexed assays for analytes in patient and other test samples. In particular, these methods have applications for Quantitative Multi-analyte Immunoassays (QMI) to measure proteins in human serum and plasma. | 2009-03-19 |
20090075829 | Plant polymorphic markers and uses thereof - The present invention is in the field of plant genetics. More specifically, the invention relates to nucleic acid markers associated with | 2009-03-19 |
20090075830 | SYSTEM FOR IDENTIFYING AND ANALYZING EXPRESSION OF ARE-CONTAINING GENES - The present invention relates to a gene discovery system and gene expression systems specific for genes encoding ARE-containing mRNAs. In one aspect, the present invention relates to computational methods of selecting coding sequences of ARE-genes from databases using a one or more ARE search sequences. The ARE search sequences are from 10 to 80 nucleotides in length and comprise a sequence which is encompassed by one of the following two sequences: (a) WU/T(AU/TU/TU/TA)TWWW, SEQ ID NO. 1, wherein none or one of the nucleotides outside of the parenthesis is replaced by a different nucleotide, and wherein W represents A, U, or T; and (b) U/T(AU/TU/T/U/T)n, SEQ ID NO. 2 wherein n indicates that the search sequence comprises from 3 to 12 of the tetrameric sequences contained within the parenthesis. The method comprises extracting from the databases, those nucleic acids whose protein coding sequences are upstream and contiguous with a 3′ untranslated region (UTR) that comprises one of the ARE search sequences. The present invention also relates to methods of selectively amplifying RNA and cDNA molecules using primers derived from and complementary to the consensus 5′ sequence motifs and primers derived from and complementary to the ARE search sequence. The present invention also relates to methods of selectively amplifying ARE genes which employ a 3′ primer which is from 15 to 50 nucleotides and length and comprises from 2 to 10 pentamers having the sequence TAAAT. The pentameric sequences in the primers are either overlapping or non-overlapping. The 3′ primers are used in the reverse transcription step of the methods, the polymerase chain reaction (PCR) amplification step of the methods, or in both the reverse transcription step and the PCR amplification step of the methods. The present invention also relates to methods of making libraries which comprise portions of the ARE genes that are selectively amplified by the present methods and to methods of making microarrays which comprise probes that hybridize under stringent conditions to portions of the protein coding sequences of the ARE genes that are selectively amplified by the present methods. The present invention also relates to libraries and the microarrays that are made by such methods. | 2009-03-19 |
20090075831 | METHOD FOR DIFFERENTIATING BETWEEN THE NON-INFECTIOUS AND INFECTIOUS CAUSES OF MULTIPLE ORGAN FAILURE - The present invention relates to the use of gene expression profiles obtained in vitro from patient samples for differentiating between the non-infectious and infectious causes of multiple organ failure. The invention also relates to a method for measuring gene expression profiles in vitro and the use of said gene expression profiles and/or of the probes used therein for screening active substances against the non-infectious and/or infectious causes of multiple organ failure. | 2009-03-19 |
20090075832 | Compositions and Methods for Classifying Biological Samples - The present invention relates to autoantibodies and the detection thereof with peptide epitopes. The invention also relates to autoantibody patterns and their correlation with biological class distinctions. | 2009-03-19 |
20090075833 | ADRB2 CANCER MARKERS - The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ADRB2 markers for cancer. | 2009-03-19 |
20090075834 | Aptamers and methods for their in vitro selection and uses thereof - The present method is an improved in vitro selection protocol that relies on magnetic separations for DNA aptamer production that is relatively easy and scalable without the need for expensive robotics. The ability of aptamers selected by this method to recognize and bind their target protein with high affinity and specificity, and detail their uses in a number of assays is also described. Specific TTF1 and His6 aptamers were selected using the method described, and shown to be useful for enzyme-linked assays, Western blots, and affinity purification. | 2009-03-19 |
20090075835 | METHODS AND SYSTEMS FOR THE DETECTION OF MICRODELETION AND MICRODUPLICATION SYNDROMES - Methods for diagnosing the presence or absence of a genetic disorder in a patient are provided, wherein the genetic disorder is associated with a chromosomal abnormality at 1q41q42 and/or 16p11.2p12.2, and wherein the genetic disorder is not Fryns syndrome or congenital diaphragmatic hernia (CDH). Materials, such as microarrays for use in microarray CGH, and kits for use in such methods are also provided. | 2009-03-19 |
20090075836 | SCREENING FOR MODULATORS OF METALATION PATHWAYS FOR METALLOPROTEINS - The present invention is directed to compositions and methods for screening of metalation pathways for the metalation of metalloproteins. | 2009-03-19 |
20090075837 | FRAMELESS MULTIPLEXED MICROARRAYS - The present invention relates to novel methods for the quantitative detection of molecules in an array. In particular, the present invention relates to methods and apparatuses for producing a frameless array. In another embodiment, the present invention relates to a composition comprising nitrocellulose that is useful of producing a frameless array. In another embodiment, the present invention relates to a method for detecting a molecular interaction. In yet another embodiment, the present invention relates to kits useful for practicing the methods and apparatuses of the present invention. The present invention provides improved methods and apparatuses for the high throughput analysis of molecular interactions and quantitative detection. | 2009-03-19 |
20090075838 | Biological Analysis Arrangement and Approach Therefor - Characteristics of a chemical or biological sample are detected using an approach involving light detection. According to an example embodiment of the present invention, an assaying arrangement including a light detector is adapted to detect light from a sample, such as a biological material. A signal corresponding to the detected light is used to characterize the sample, for example, by detecting a light-related property thereof. In one implementation, the assaying arrangement includes integrated circuitry having a light detector and a programmable processor, with the light detector generating a signal corresponding to the light and sending the signal to the processor. The processor provides an output corresponding to the signal and indicative of a characteristic of the sample. | 2009-03-19 |
20090075839 | Novel streptococcus pneumoniae open reading frames encoding polypeptide antigents and uses thereof - The present invention relates to newly identified open reading frames comprised within the genomic nucleotide sequence of | 2009-03-19 |
20090075840 | Methods And Compositions For Generating Mixtures Of Nucleic Acid Molecules - In some embodiments, the present disclosure provides methods of making a mixture of nucleic acid molecules, the methods comprising the steps of: synthesizing on a substrate a population of nucleic acid molecules wherein each synthesized nucleic acid molecule comprises a substrate-attached proximal nucleic acid molecule, a distal nucleic acid molecule, and a cleavable linker linking the proximal nucleic acid molecule to the distal nucleic acid molecule, and harvesting distal nucleic acid molecules from the substrate by cleaving the cleavable linker under conditions that do not release the proximal nucleic acid molecule. Related compositions and kits are also provided. | 2009-03-19 |
20090075841 | NUCLEIC ACIDS ARRAYS AND METHODS OF USE THEREFOR - Compilations of nucleic acids, articles of manufacture which are surfaces comprising multiple blocks of arrays comprising such compilations, methods of use of the compilations and arrays for detection of chromosomal disorders, such as a chromosomal aneuploidies, deletions, amplifications, and diagnosis and prognosis of syndromes associated with a contiguous gene abnormality and kits are provided. | 2009-03-19 |
20090075842 | NEOGLYCORANDOMIZATION AND DIGITOXIN ANALOGS - The present invention provides methods of producing libraries of compounds with enhanced desirable properties and diminished side effects as well as the compounds produced by the methods. In preferred embodiments, methods of the present invention use a universal chemical glycosylation method that employs reducing sugars and requires no protection or activation. In a preferred embodiment, the invention provides a library of neoglycoside digitoxin analogs that includes compounds with significantly enhanced cytotoxic potency toward human cancer cells and tumor-specificity, but are less potent Na | 2009-03-19 |
20090075843 | Biological Sensor System - Disclosed is a system using each of the descrete emitters in a III-nitride micro-emitter array as a light source for measuring the properties of independent samples of biological materials deposed on a micro-array using some form of detecting device, e.g, a detector array or charge-coupled device. In embodiments the emitter array produces deep ultraviolet in investigating protein-protein interactions or to detect biological and chemical molecules with high specificity by monitoring changes in a protein's intrinsic fluorescence. | 2009-03-19 |
20090075844 | Method and composition for controlling inorganic fluoride scales - The productivity of hydrocarbons from hydrocarbon-bearing calcareous or siliceous formations is enhanced by contacting the formation with a well treatment composition which contains a hydrofluoric acid source, a boron containing compound and a phosphonate acid, ester or salt thereof. | 2009-03-19 |
20090075845 | Degradable Polymers for Wellbore Fluids and Processes - A viscosifying agent for wellbore fluids is described including a polymer polymerized using at least two pre-polymers “A” and “B”, the polymer being capable of essentially fully degrading into soluble fragments after the initiation of a breaking process. | 2009-03-19 |
20090075846 | Compositions for Treating a Well Penetrating a Subterranean Formation and Uses Thereof - Fluid producing wells may be treated with a water-in-oil emulsion for the removal or inhibition of unwanted solid particulates, including pipe dope, asphaltenes and paraffins. Such emulsions are of particular applicability in the displacement of oil base drilling muds and/or residues from such muds from producing wells. The water-in-oil emulsions may optionally contain a dispersing agent as well as a surfactant. | 2009-03-19 |
20090075847 | DRILLING FLUID LUBRICANT AND METHOD OF USE - A method for increasing drilling rates by reducing torque and drag in hostile environments such as high pressure, high temperature, and horizontal wells is provided by adding chemically and thermally inert spherical carbon beads to the drilling fluid. | 2009-03-19 |
20090075848 | ENVIRONMENTALLY COMPATIBLE DEFOAMING COMPOSITION FOR USE IN FLUIDS - Defoaming compositions for reducing the amount of gas present in a fluid such as a cement composition are provided. In an embodiment, a defoaming composition includes a carboxylic acid compound or an ester of a carboxylic acid compound; an alpha olefin compound; and an alcohol compound. | 2009-03-19 |
20090075849 | OIL-SOLUBLE MOLYBDENUM DERIVATIVES DERIVED FROM HYDROXYETHYL-SUBSTITUTED MANNICH BASES - The present disclosure relates to organic molybdenum complexes prepared by reacting a Mannich base with a source of molybdenum. The complexes may be useful in lubricating oil compositions as at least one of an antioxidant, a deposit control additive, and a friction modifier. The organic molybdenum complexes may show a reduced tendency to color finished oils. | 2009-03-19 |
20090075850 | ASHLESS HYDRAULIC FLUID OR PAPER MACHINE OIL - An ashless lubricating oil, comprising a base oil having greater than 90 wt % saturates, less than 10 wt % aromatics, a viscosity index greater than 130, low sulfur, and a sequential number of carbon atoms. The lubricating oil has a VI between 155 and 300, greater than 680 minutes in a rotary pressure vessel oxidation test, and a kinematic viscosity at 40° C. from 19.8 to 748 cSt. An ashless paper machine oil, comprising a base oil having a sequential number of carbon atoms, wherein the oil has a defined viscosity index and high oxidation stability. Also, an ashless lubricating oil, comprising a base oil having a viscosity index greater than 150, wherein the base oil is made from a blend of petroleum-based wax and Fischer-Tropsch derived wax. | 2009-03-19 |
20090075851 | NOVEL SILOXANE CONTAINING BLOCK COPOLYMERS, PROCESS FOR THEIR PREPARATION AND THEIR USE FOR LUBRICANTS - The invention relates to novel polyester-polysiloxane block copolymers, to a process for their preparation and to the use of these polymers as a base oil or as an additive in lubricants, especially silicone oils. | 2009-03-19 |
20090075852 | Low Ash Engine Oil Composition - The present invention provides a low ash engine oil composition which, despite the low ash content, has engine detergency which enables the composition to pass severe detergency tests for diesel engine oils. The engine oil composition contains 0.6 percent by mass or less of a sulfated ash and comprises a low ash engine oil composition with a sulfated ash content of 0.6 percent by mass or less, which comprises: a lubricating base oil with a % C | 2009-03-19 |
20090075853 | RELEASE ADDITIVE COMPOSITION FOR OIL FILTER SYSTEM - A slow release liquid additive concentrate for use in an engine oil filter and a method for extending an oil drain interval for an engine. The additive concentrate has therein at least one detergent and at least one antioxidant. The additive concentrate has a tan delta of greater than about 5. | 2009-03-19 |
20090075854 | HAIR CLEANSING COMPOSITIONS - A hair cleansing composition comprises the following ingredients (A) to (C):
| 2009-03-19 |
20090075855 | Delivery Cartridge - A dishwasher detergent delivery cartridge comprises a plurality of unit dose elements of a dishwasher detergent composition, the composition being a substantially coherent mass and comprising at least 20 wt % of methyl glycine diacetic acid and/or a salt thereof and/or of glutamic diacetic acid and/or a salt thereof. | 2009-03-19 |
20090075856 | Encapsulated Bleaching Agent Particles - A shelf-stable liquid agent or detergent containing a bleaching agent in the form of a finely particulate bleaching agent encapsulated in a crosslinkable polymer matrix. | 2009-03-19 |
20090075857 | Clear Detergent or Cleaning Agent Having a Flow Limit - The invention relates to an aqueous detergent or cleaning agent, containing one or more surfactants, a polyacrylate as a thickening agent, a solvent component comprising dipropylene glycol, in addition to other usual detergent and cleaning agent substances. The thus obtained aqueous detergent or cleaning agent is clear, transport and storage stable, has a flow limit and can disperse particles in a stable manner and over a long period of time. | 2009-03-19 |
20090075858 | PROCESS FOR TREATING INCLINED HARD SURFACE - The present invention relates to a process of treating a hard surface with a composition comprising polyalkoxylate trisiloxane. More specifically, it relates to a process of treating an inclined or vertical hard surface, wherein a composition comprising polyalkoxylate trisiloxane is applied onto said hard surface. | 2009-03-19 |
20090075859 | FRAGRANCE COMPOSITION - A fragrance composition containing 0.0005 to 10% by mass of a decalin alcohol as component (a) represented by formula ( | 2009-03-19 |
20090075860 | TRANSDERMAL ABSORPTION ENHANCER - An object of the present invention is to provide a transdermal absorption enhancer by which various active ingredients are transdermally absorbed. In accordance with a transdermal absorption enhancer of the present invention which effective ingredient is lyotropic liquid crystal which has been utilized as a basic material for pharmaceutical preparations for external application and for cosmetics, transdermal absorption of a macromolecular substance and a water-soluble substance was able to be improved. | 2009-03-19 |
20090075861 | SYSTEMS AND METHODS OF REMOVING AND MANAGING HEAVY METALS - Systems and methods remove and manage heavy metals. In one implementation, an exemplary method can be applied to food processing and food consumption to remove heavy metals such as mercury, lead, uranium and cadmium before absorption by a living organism. The exemplary method exposes the food to a heavy-metal binding ligand, such as a concentrated protein or phytic acid, to form a heavy-metal chelate, and then allows the chelate to separate from the food. In another implementation, an exemplary probe possesses innovative molecular layers on its surface to detect and quantify heavy metals by attracting and binding traces of the heavy metals on a ligand layer. | 2009-03-19 |
20090075862 | METHOD FOR PROVIDING GLUTAMINE - A method of providing glutamine to a patient. A nutritional composition which includes whey protein, or a protein mixture which simulates the amino acid profile of whey protein, as a protein source is enterally administered to the patient. The whey protein may be a hydrolyzed whey protein. The patient may be a stressed patient, pre-term baby, or athlete. | 2009-03-19 |
20090075863 | Periosteal Tissue Grafts - This document relates to methods and materials involved in making and using periosteal tissue grafts in vivo. For example, materials and methods for obtaining grafts comprising periosteal tissue are provided. | 2009-03-19 |
20090075864 | COMBINATION THERAPY COMPRISING GLUCOSE REABSORPTION INHIBITORS AND RETINOID-X RECEPTOR MODULATORS - Combination therapy comprising RXR modulators and glucose reabsorption inhibitors useful for the treatment of diabetes and Syndrome X are disclosed. | 2009-03-19 |
20090075865 | Novel medicament for ameliorating dyskinesia - A novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from said protein is provided. The novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, according to the present invention is suitably applicable to diseases with decrease in motor function. | 2009-03-19 |
20090075866 | METHOD TO ENHANCE HEMODYNAMIC STABILITY USING OXYGEN CARRYING COMPOSITIONS - The present invention relates to methods for enhancing the hemodynamic stability of an individual undergoing surgery by administering a composition comprising a hemoglobin-based oxygen carrier. In one embodiment, the present invention relates to the use of polyalkylene oxide modified hemoglobins with reduced cooperativity and a high oxygen affinity to enhance oxygen offloading as a preventative measure to avoid hemodynamic stability-related complications during surgery. | 2009-03-19 |
20090075867 | Triazine compounds and compositions thereof for the treatment of cancers - Compounds useful in the treatment of metastatic melanoma and other cancers containing a triazine ring scaffold are described. These compounds may be classified into two groups: (1) two disubstituted triazine rings are covalently linked by an organic linker to each other and (2) one trisubstituted triazine ring. | 2009-03-19 |
20090075868 | Synthetic peptide materials for joint reconstruction, repair and cushioning - In joint reconstruction, repair and cushioning applications, a synthetic polypeptide material is useful that contains cross-linked polypeptides that are modeled on human elastin or other fibrous proteins. The polypeptides comprise at least three consecutive beta-sheet/beta-turn structures and at least one amino acid residue that participates in cross-linking. | 2009-03-19 |
20090075869 | HCV NS3 protease inhibitors - The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections. | 2009-03-19 |
20090075870 | DEUTERIUM-ENRICHED CASPOFUNGIN - The present application describes deuterium-enriched caspofungin, pharmaceutically acceptable salt forms thereof, and methods of treating using the same. | 2009-03-19 |
20090075871 | Modified Thioredoxin - The present invention relates to a human modified thioredoxin composed of any of the following polypeptides: (a) a polypeptide modified by alteration or chemical modification of a cysteine residue at position 35 with another amino acid in an amino acid sequence of SEQ ID NO:2; and (b) a polypeptide having an amino acid sequence having one or more substituted, deleted, inserted or added amino acids in positions except for positions 32 and 35, preferably positions 32 to 35 in the amino acid sequence of SEQ ID NO:2, and having an apoptosis-inducing activity. | 2009-03-19 |
20090075872 | METHODS AND MEANS - This invention relates to methods and means for the stimulation of phagocytosis and in particular to the phagocytosis of apoptotic cells, and discloses a role for the protein product of the apoE gene (apolipoproteinE) as a regular of apoptotic cell clearance. ApoE mimetics and other compounds which stimulate the clearance of apoptotic cells may be useful in the treatment of a range of disorders. One aspect of the invention provides a method of identifying and/or obtaining a compound for the treatment of a condition associated with decreased endogenous apoE activity in an individual comprising: determining the ingestion of apoptic cells by a macrophage in the presence of a test compound. An increase in apoptic cell ingestion in the presence relative to the absence of test compound may be indicative that the compound may be useful in the treatment of a condition associated with decreased endogenous apoE activity. | 2009-03-19 |
20090075873 | Gastrin compositions and formulations, and methods of use and preparation - The present invention concerns six novel variants of alternative splicing of the CD40 receptor. | 2009-03-19 |
20090075874 | Methods for construction and screening of libraries of chemokine variants - The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral diseases, as well as clues for preventing and/or curing inflammatory or malignant diseases. | 2009-03-19 |
20090075875 | PROTECTION AGAINST LUNG FIBROSIS BY UP-REGULATING THE FUNCTION OR EXPRESSION OF CAVEOLIN-1 - Disclosed are compositions and methods for the treatment of fibrosis. Also disclosed are methods of screening for agents that treat fibrosis. | 2009-03-19 |
20090075876 | Altered insulin-like growth factor binding proteins - Altered IGFBPs are able to bind IGF, but the release is inhibited by resistance to protease cleavage and/or reduced binding to extracellular matrix (ECM). Alterations have been made in IGFBP-2 to the linker domain in particular and to two amino acid motifs found to be important for ECM binding. IGF-1 mediated proliferation of cancer cells have been inhibited by use of the altered IGFBPs. | 2009-03-19 |
20090075877 | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides - The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or versants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides. | 2009-03-19 |
20090075878 | Methods for Generating and Screening Fusion Protein Libraries and Uses Thereof - The invention provides methods for generating fusion protein libraries, such as immunotoxin libraries. The invention also relates to libraries of recombinant cells encoding nucleic acid sequences comprising fusion proteins. In addition, the invention relates to the libraries themselves and the use of the libraries to screen for fusion proteins that are specific for target cells, such as cancer cells. Further, the invention relates to methods of improving fusion proteins and to the improved fusion proteins. | 2009-03-19 |
20090075879 | Novel Peptide Compositions and the Use Thereof, in Particular, in the Preparation of Active Pharmaceutical Compositions Against the Hepatitis C Virus - The invention relates to novel peptide compositions. In particular, the invention relates to a peptide composition comprising at least two peptides which are selected from among the following peptides: a peptide A having at least the amino acid sequence of SEQ ID No1, a peptide B having at least the amino acid sequence of SEQ ID No45, a peptide C having at least the amino acid sequence of SEQ ID No127, and a peptide D having at least the amino acid sequence of SEQ ID No 174. The inventive compositions can be used, in particular, in the preparation of active pharmaceutical compositions against the hepatitis C virus. | 2009-03-19 |
20090075880 | Albumin Fusion Proteins - The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention. | 2009-03-19 |
20090075881 | FIBRIN GEL FOR CONTROLLED RELEASE OF PDGF AND USES THEREOF - The present invention relates, in general, to fibrin sealants, which contain platelet derived growth factor (PDGF) for controlled release in situ for therapeutic applications, including musculoskeletal disorders, soft tissue disorders and vascular diseases. | 2009-03-19 |
20090075882 | RECEPTOR-MEDIATED UPTAKE OF AN EXTRACELLULAR BCL-XL FUSION PROTEIN INHIBITS APOPTOSIS - Apoptosis-modifying fusion polypeptides, and the corresponding nucleic acid molecules, are disclosed. Pharmaceutical compositions comprising these polypeptides, and the use of these polypeptides to modify apoptosis, are also provided. | 2009-03-19 |
20090075883 | Compositions for the treatment of cancer, and methods for testing and using the same - A composition comprising leukotoxin proteins isolated from a bacterium is provided. In this composition, greater than 85% of the leukotoxin proteins are chemically modified at a basic amino acid residue, and the proteins induce cell death in myeloid leukocytes, while remaining substantially non-toxic to lymphoid leukocytes, lymphocytes, and red blood cells. Also provided is a method of selectively inducing cell death in myeloid leukocytes. The method comprises contacting the myeloid leukocytes with a composition comprising leukotoxin proteins. These leukotoxin proteins may be isolated from the NJ | 2009-03-19 |
20090075884 | HUMAN IL-17F AND OTHER IL-17F-RELATED PROTEINS AND METHODS RELATED THERETO - Polynucleotides encoding human CTLA-8 and related proteins are disclosed. Human CTLA-8 proteins and methods for their production are also disclosed. Methods of treatment using human CTLA-8 proteins, rat CTLA-8 proteins and herpesvirus herpes CTLA-8 proteins are also provided. | 2009-03-19 |
20090075885 | ANTITUMOR EFFECT OF MUTANT BIK - The present invention regards mutant forms of Bik that comprise anti-cell proliferation and/or pro-apoptotic activities. In particular embodiments, the Bik polypeptides comprise a substitution at Thr33 and Ser35 and, in some embodiments, phosphorylation at these sites is inhibited. In more particular embodiments, these forms are useful for cancer therapy, particularly when administered in combination with liposomes. In embodiments wherein a mutant Bik polynucleotide is administered for cancer therapy, the polynucleotide may be regulated in a tissue-specific manner. | 2009-03-19 |
20090075886 | Dendritic cell stimulatory factor - Flt3-ligand can be used to generate large numbers of dendritic cells from hematopoietic progenitor and stem cells. Flt3-ligand can be used to augment immune responses in vivo, and expand dendritic cells ex vivo. Such dendritic cells can then be used to present tumor, viral or other antigens to naive T cells, can be useful as vaccine adjuvants. | 2009-03-19 |
20090075887 | Treatment with Kallikrein Inhibitors - Methods, kits and compositions are disclosed that include a non-naturally occurring kallikrein inhibitor and optionally a viscosupplement for the treatment of joint pathology. | 2009-03-19 |
20090075888 | Cardiovascular and Brain Cell Therapy Using Intracellular Ryanodine Receptor Modulation by the Estrogen Receptor Beta - The present invention includes compositions and methods for screening for a candidate substance with ryanodine receptor (RyR)-modulatory activity, the method including: determining the ion-conducting ability and ability to change the concentration of the free cytoplasmic intracellular Ca | 2009-03-19 |
20090075889 | IREN PROTEIN, ITS PREPARATION AND USE - There are provided DNA sequences encoding TRAF binding proteins, proteins encoded thereby, and their use in the treatment or prevention of pathological conditions associated with NF-κB induction, or an activity mediated by a TRAF. | 2009-03-19 |
20090075890 | Long lasting synthetic exendin-4 peptide conjugates and methods of use thereof - Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases. | 2009-03-19 |
20090075891 | Methods and dressings for sealing internal injuries - Disclosed are solid and frozen haemostatic materials and dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings. | 2009-03-19 |
20090075892 | Synthetic pulmonary surfactant peptides - The present invention is directed to a reconstituted surfactant comprising a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide analog of the native surfactant protein SP-B. The invention is also directed to the pharmaceutical compositions thereof and to a use thereof in the treatment or prophylaxis of RDS and other respiratory disorders. | 2009-03-19 |
20090075893 | Inhibition of Angiogenesis by Neutrophil Alpha-Defensins - The present invention relates to the inhibition of angiogenesis by neutrophil alpha-defensins. Further, the present invention relates to methods involving the inhibition of endothelial cell adhesion to the extracellular matrix, endothelial cell apoptosis, and endothelial cell angiogenesis mediated by alpha-defensins. | 2009-03-19 |
20090075894 | Novel Bacillus Thuringiensis Gene with Coleopteran Activity - The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of | 2009-03-19 |
20090075895 | Stabilised Solid Composition of Modified Factor VII - The invention concerns a composition comprising; i) Modified Factor VII; ii) an agent suitable for keeping the pH of said composition in the range of 4 to 7 when said composition is dissolved in water; and iii) a moisture content of at the most 3%. | 2009-03-19 |
20090075896 | NOVEL ANTIHYPERTENSIVE PEPTIDE AND USE THEREOF - The present invention provides a novel antihypertensive peptide. Also provided are pharmaceutical and food compositions containing the antihypertensive peptide for treating hypertension or cardiovascular disease. | 2009-03-19 |
20090075897 | Peptides derived from the C2 domain of epsilon PKC and methods of use, thereof - Peptides derived from the C2 regions of εPKC and methods of use, thereof, are described. These peptides modulate the activity of εPKC in an animal model of acute ischemic heart disease. | 2009-03-19 |
20090075898 | Complement C3A Derived Peptides and Uses Thereof - Peptides corresponding partially to positions 55-64 of the sequence of the complement component peptide C3a are capable of preventing and treating mast cell- and basophil-mediated disorders by inhibiting IgE- or IgG-mediated triggering and/or by inhibiting the FcεRI- and/or FcγR-induced secretory response, while obviating the anaphylatoxic response. These peptides are useful for prevention and/or treatment of allergic disorders where mucosal-type and/or serosal-type mast cells and/or basophils are involved such as asthma, allergic dermatosis, and gastrointestinal allergies. | 2009-03-19 |
20090075899 | Inhibiting collagen-induced platelet aggregation and activation with peptide variants - The present invention provides peptides consisting of L- and/or D-amino acids and combinations thereof, which affect platelets by action on the collagen receptor, glycoprotein VI (GPVI). More specifically, however, the peptides act on the GPVI-FcRγ signaling complex. The invention also provides lipid and sugar conjugated peptides comprising L- or D-amino acids. The invention still further provides a method of designing of the peptides and lipid- and/or sugar-conjugated peptides comprising L- or D- amino acids. The present invention further relates to the therapy of various disease states involving the use of these peptides and compounds. Specifically, the peptides and compounds are useful in the treatment and/or prevention of a disease or condition involving platelet activation and aggregation, and more particularly, collagen-induced platelet activation and aggregation. They also are useful in the production of medical devices comprising peptide matrices (i.e., for example, cardiovascular stents). | 2009-03-19 |
20090075900 | Therapeutic agent for motor neuron disease - An object of the present invention is to provide an agent effective for the treatment and/or prevention of motor neuron disease such as amyotrophic lateral sclerosis (ALS). The present invention provides a therapeutic and/or preventive agent for motor neuron disease comprising the following oligopeptide shown in any of (a) to (c) or a pharmaceutically acceptable salt thereof as an active ingredient: (a) an oligopeptide consisting of the amino acid sequence represented by Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala (SEQ ID NO: 1); (b) an oligopeptide consisting of an amino acid sequence having a deletion, substitution, insertion, or addition of one or several amino acids in Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala (SEQ ID NO: 1), and having an activity that inhibits neuronal cell death caused by a mutant superoxide dismutase-1 gene; and (c) a modified oligopeptide from the oligopeptide (a) or (b). | 2009-03-19 |
20090075901 | PEPTIDES FOR ACTIVATION AND INHIBITION OF DELTAPKC - Peptides able to inhibit or activate the translocation or function of δPKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for δPKC-selective agonists and antagonists. | 2009-03-19 |
20090075902 | INHIBITING THE SIGNS OF AGING BY INHIBITING NF-KAPPA B ACTIVATION - The present invention relates to methods and compositions for reducing and/or delaying one or more signs of aging which comprise inhibiting NF-kappa B activation. It is based, at least in part, on the discovery that a peptide which inhibits IKK-β interaction with NEMO, linked to a transducing peptide, inhibits the development of various indicia of senescence in a murine model of aging, Ercc1 | 2009-03-19 |
20090075903 | METHOD OF USING SUBSTANCE P ANALOGS FOR TREATMENT AMELIORATION OF MYELODYSPLASTIC SYNDROME - Myelodysplastic syndromes can be treated or ameliorated by the administration of substance P analogs as disclosed herein. | 2009-03-19 |
20090075904 | Protein Hydrolysate Enriched In Peptides Inhibiting DPP-IV And Their Use - Disclosed is a protein hydrolysate having DPP-IV inhibiting activity, the hydrolysate being enriched in peptides having a length of 2-8 amino acids comprising at least one proline residue, an isolated peptide derivable from such a protein hydrolysate, or a mixture thereof, and the use of such protein hydrolysate or isolated peptide for the manufacture of a medicament, food supplement, beverage or food product for prophylaxis and/or treatment of a DPP-IV mediated condition, in particular chosen from the group of obesity, type 2 diabetes mellitus and an immunological disorder. | 2009-03-19 |
20090075905 | Anticancer compounds and methods - The testing of tumor cells, including human tumors capable of metastases, in assays employing fibronectin-depleted substrates is described. Ex vivo induction of cells, including biopsied human cells, is performed with invasion-inducing agents. Additionally, anti-cancer chemotherapeutics are described. Specifically, chemotherapeutic agents which have anti-metastatic and anti-growth properties are described including non-peptide compositions of matter. | 2009-03-19 |
20090075906 | OLIGOPEPTIDES AND COMPOSITIONS CONTAINING THE OLIGOPEPTIDES - Oligopeptides according to formula (I) and/or (II), R | 2009-03-19 |
20090075908 | Agent For Strengthening Calcium Containing Tissue and Use Thereof - The present invention has an object to provide an agent for strengthening calcium-containing tissues, which can be safely applied; and its use: The present invention solves the object by providing an agent for strengthening calcium-containing tissues, which comprises one or more flavones, flavonols, flavanones, flavanonols, anthocyanidins, flavanols, chalcones, and aurones. | 2009-03-19 |
20090075909 | Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds - The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds of this invention can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases, for example, bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. The present invention also relates to pharmacological compositions containing these monosaccharide derivatives, as well as methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or auto immune disorders. | 2009-03-19 |
20090075910 | DEUTERIUM-ENRICHED FONDAPARINUX - The present application describes deuterium-enriched fondaparinux, pharmaceutically acceptable salt forms thereof, and methods of treating using the same. | 2009-03-19 |
20090075911 | Ester Derivatives of Hyaluronic Acid for the Preparation of Hydrogel Materials by Photocuring - The present invention relates to hyaluronic acid ester derivatives, whose carboxylic groups are partially esterified with hydroxy groups of propiophenone derivatives, to the hydrogel materials consisting of the said hyaluronic acid ester derivatives, to their preparation process by photocuring of the hyaluronic acid ester derivatives, and their use in the biomedical, sanitary and surgical fields, and in the medical field as controlled release systems for drugs. | 2009-03-19 |
20090075912 | Use of Timosaponin BII in the Preparation Of A Medicament or Product for the Prevention and Treatment of Stroke - The invention disclosed the use of timosaponin BII in the preparation of a medicament or product for the prevention and treatment of stroke. The experiments prove that timosaponin BII can improve the neurological symptoms of cerebral ischemic rat, reduce infarct size, relieve brain water edema, improve hemorheology, reduce inflammatory injury of cerebral ischemia. | 2009-03-19 |
20090075913 | GLYCOSIDE HAVING 4-METHYLERGOST-7-EN-3-OL SKELETON AND HYPERGLYCEMIA IMPROVING AGENT - 3-O-β-D-Glucopyranosyl-4-methylergost-7-en-3-ol or a composition containing 0.001% by mass or more of the aforementioned compound, which is an extract of a plant of the family Liliaceae containing the compound or a fraction thereof, is used as an active ingredient of a hyperglycemia improving agent. | 2009-03-19 |
20090075914 | DEUTERIUM-ENRICHED ODIPARCIL - The present application describes deuterium-enriched odiparcil, pharmaceutically acceptable salt forms thereof, and methods of treating using the same. | 2009-03-19 |
20090075915 | 6,11-BICYCLOLIDES: BRIDGED BIARYL MACROLIDE DERIVATIVES - The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: | 2009-03-19 |