12th week of 2009 patent applcation highlights part 54 |
Patent application number | Title | Published |
20090076218 | Low VOC Thermosetting Polyester Acrylic Resin for Gel Coat - Low VOC thermosetting polyester acrylic resins are made by esterification of unsaturated epoxide such as glycidyl methacrylate, and a polyacid which is the half-ester formed by reacting an acid or its anhydride with a polyol is disclosed. The obtained low viscosity resin is useful for making a low or zero VOC gel coat with excellent hydrolytic and weather resistance. | 2009-03-19 |
20090076219 | COMPOSITION FOR IMAGE RECORDING, IMAGE RECORDING INK SET, AND RECORDING APPARATUS - A composition for image recording includes a curable material that is curable by an external stimulus, and an oil absorbing material. | 2009-03-19 |
20090076220 | UNDERFILL FORMULATION AND METHOD OF INCREASING AN ADHESION PROPERTY OF SAME - An underfill formulation includes a solvent ( | 2009-03-19 |
20090076221 | REMOVAL OF BRANCHED DIBENZOTHIOPHENES FROM HYDROCARBON MIXTURES VIA CHARGE TRANSFER COMPLEXES WITH A TAPA-FUNCTIONALIZED ADSORBENT - A process for producing an adsorbent where a metal oxide is reacted with an alkoxy silane to produce an epoxy-functionalized metal oxide. This product is reacted with an amino-substituted propionic acid and a nitro-substituted fluorenone, and this product is grafted to the epoxy-functionalized metal oxide. This grafted product is the adsorbent, which may be contacted with a hydrocarbon mixture having at least one sulfur containing compound in order to remove this sulfur containing compound. Also disclosed is a process for adding polymerization groups to an adsorbent. | 2009-03-19 |
20090076222 | CLEAR FUNCTIONAL COATING FOR ELASTOMERS - A coating composition comprising a polycarbonate-based polyurethane, and a polyester-based polyurethane, which is substantially free of siloxane compounds, wherein when the coating composition is applied to a substrate, dried, and crosslinked, it has a delta E of less than 3.0 after exposure to 1240kJ/m2 of ultraviolet light. In a more preferred embodiment of the present invention, the delta E is less than 2.0. | 2009-03-19 |
20090076223 | SHAPE MEMORY POLYMER WITH POLYESTER AND POLYACRYLATE SEGMENTS AND PROCESS FOR ITS PRODUCTION AND PROGRAMMING - The invention relates to a shape memory polymer, to a process for its production and to a process for its programming. The inventive shape memory polymer has at least two switching segments with different transition temperatures (T | 2009-03-19 |
20090076224 | Composite Material Comprising Flourine-Containing Rubber, Fuel-Impermeable Sealing Material Comprising Same, and Process for Preparing Composite Material - The present invention provides a novel fluorine-containing rubber composite material having both of excellent fuel impermeability and excellent cold resistance, a fuel impermeable sealing material comprising the composite material and a process for preparing the composite material. The fluorine-containing rubber composite material comprises crosslinked particles of fluorine-containing silicone rubber dispersed in a fluorine-containing rubber. It is preferable that the fluorine-containing rubber comprises a vinylidene fluoride/tetrafluoroethylene/perfluoro vinyl ether copolymer, and the composite material has cold resistance of not more than −35° C. and fuel permeability of not more than 500 g·mm/m | 2009-03-19 |
20090076225 | VULCANIZABLE HALOGENATED ELASTOMER COMPOSITIONS - The invention provides compositions comprising nitrogen containing chelating agents, which can be used to reduce the effects of zinc contamination on the vulcanization rates of polymercapto based cure systems for halogenated elastomers. Such chelating agents are effective at eliminating vulcanization rate inconsistencies due to zinc contamination, without inducing negative changes to the vulcanization reaction or the subsequent physical properties of the halogenated elastomer vulcanizate. The invention also provides methods of curing a halogenated elastomer using the inventive compositions, and for articles prepared from the same. | 2009-03-19 |
20090076226 | CATALYSTS FOR METATHESIS REACTIONS - Novel catalysts for metathesis reactions, in particular for the metathesis of nitrile rubber, are provided. | 2009-03-19 |
20090076227 | PROCESS FOR THE METATHETIC DEGRADATION OF NITRILE RUBBER - The metathetic degradation of nitrile rubber can be improved by use of a combination of metal-carbene complex catalysts with specific transition metal additives. | 2009-03-19 |
20090076228 | POLYISOCYANATE MIXTURES - The invention relates to liquid polyisocyanate mixtures, to a process for their preparation and to their use in single- and two-component polyurethane coating compositions. | 2009-03-19 |
20090076229 | Imide-naphthoxazine copolymer - An imide-naphthoxazine copolymer comprising a repeating unit represented by General Formula (1) below: | 2009-03-19 |
20090076230 | Process for preparing compositionally uniform copolymers - This invention relates to semi-batch type copolymerization processes. More specifically, the processes of the present invention are directed to the production of compositionally uniform copolymers, including the production of such copolymers from dissimilar monomers, e.g., from monomers with significantly different reactivity ratios. | 2009-03-19 |
20090076231 | Production of polymers in a conical reactor - The present invention provides a process for the preparation of polymer which comprises the steps of i) feeding an aqueous mixture comprising a monoethylenically unsaturated monomer or a mixture of monoethylenically unsaturated monomers and an initiator into the top of a reactor ii) polymerizing the monoethylenically unsaturated monomer to form a gel-like aqueous mixture comprising the polymer, iii) squeezing the gel-like aqueous mixture comprising the polymer out of the bottom of the reactor using inert gas, wherein the reactor is either a vertical fully conical reactor having an angle (alpha) between top diameter (d | 2009-03-19 |
20090076232 | PROCESS FOR OPERATING A CONTINUOUS REMOVAL OF A TARGET PRODUCT X IN THE FORM OF FINE CRYSTALS OF THE TARGET PRODUCT X - A process for operating a continuous removal of a target product X in the form of fine crystals of a liquid phase P comprising the target product X and constituents other than the target product X by cooling suspension crystallization in the secondary chamber of an indirect heat exchanger to which liquid phase P flows continuously with simultaneous continuous flow through the primary chamber of the indirect heat exchanger with a coolant, and continuous withdrawal of a crystal suspension S having a degree of crystallization Y from the secondary chamber in two operating states I and II, wherein the coolant temperature is lower, the mass flow of liquid phase P is greater and the molar proportion of the constituents other than the target product X in the liquid phase P in operating state II is greater than in operating state I. | 2009-03-19 |
20090076233 | HYBRID POLYMER AND METHOD FOR PRODUCTION THEREOF - A novel hybrid polymer has a structure in which a polyolefin segment and a polar polymer segment are connected not via a bonding group containing a heteroatom. A method of the invention produces the hybrid polymer with industrial advantages. | 2009-03-19 |
20090076234 | PROCESS OF FREE-RADICAL POLYMERIZATION OR CROSSLINKING IN THE PRESENCE OF A SELECTED ORGANIC PEROXIDE PREPARED BY AN EX SITU PROCESS - The invention relates to free-radical polymerization and free-radical cross-linking and more particularly provides a process of free-radical polymerization or cross-linking wherein at least one polymerizable monomer or at least one compound to be cross-linked is contacted in the presence of at least one selected organic peroxides, characterized in that the organic peroxide is prepared continuously by an ex situ process with the aid of a closed plate exchanger. In the process according to the invention, it's possible to introduce the above selected organic peroxide continuously during the polymerization or cross-linking reaction. | 2009-03-19 |
20090076235 | COPOLYMERIZABLE METHINE AND ANTHRAQUINONE COMPOUNDS AND ARTICLES CONTAINING THEM - This invention relates to polymerizable ultraviolet light absorbers and yellow colorants and their use in ophthalmic lenses. In particular, this invention relates to polymerizable ultraviolet light absorbing methine compounds and yellow compounds of the methine and anthraquinone classes that block ultraviolet light and/or violet-blue light transmission through ophthalmic lenses. | 2009-03-19 |
20090076236 | HIGH-DENSITY POLYETHYLENE COMPOSITIONS AND METHOD OF MAKING THE SAME - The instant invention is a high-density polyethylene composition, and method of making the same. The high-density polyethylene composition of the instant invention includes an ethylene alpha-olefin copolymer having a density in the range of 0.935 to 0.952 g/cm | 2009-03-19 |
20090076237 | Factor VIII Polymer Conjugates - The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same. | 2009-03-19 |
20090076238 | Mono-or Poly-Quarternary Polysiloxanes - Monoquaternary or polyquaternary polysiloxanes are useful as surface finishing components, for example, in cosmetic formulas for skin and hair care, in polishes for the treatment of hard surfaces, in formulas for the drying of automobiles and other hard surfaces after machine washing, for the treatment of textiles and textile fibers, as separate softeners for textiles following the washing whereof with nonionic or anionic/non-ionic detergent formulas, or as softeners in formulas for textile washing based on non-ionic or anionic/non-ionic surfactants, whereby amino groups are used in the form of amines or amine salts as a function of pH value. | 2009-03-19 |
20090076239 | HIGH PERFORMANCE POLYURETHANE ELASTOMERS FROM MDI PREPOLYMERS WITH REDUCED CONTENT OF FREE MDI MONOMER - Polyurethane prepolymers having a reduced amount of unreacted monomeric diisocyanate, particularly diphenylmethane diisocyanate (MDI), prepared by distilling the prepolymer reaction product in the presence of at least one inert solvent whose boiling point is slightly below that of the monomeric diisocyanate; and to high performance cast polyurethane elastomers from the thus obtained prepolymers using diamine and/or diol chain extenders. | 2009-03-19 |
20090076240 | COMPOUNDS HAVING ISOCYANATE FUNCTIONAL GROUP SUBSTITUENTS AND COATING COMPOSITIONS COMPRISED THEREOF - Novel compounds having an average isocyanate functionality of greater than 2 are synthesized by the reaction of a (poly)isocyanate having an average functionality of greater than 2, with a compound X comprising a function B(H) | 2009-03-19 |
20090076241 | BIOMIMETIC COMPOUNDS AND SYNTHETIC METHODS THEREFOR - Synthesis methods for creating polymeric compounds comprising dihydroxyphenyl derivatives (DHPD), or DHPp i.e. polymers modified with DHPD, with desired surface active effects are described. The polymer backbone of DHPp has structural or performance features that can be tailored to control physical properties of DHPp, allowing it to be useful for different applications i.e. tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings. | 2009-03-19 |
20090076242 | CATALYST FOR POLYESTER POLYCONDENSATION AND METHOD FOR PRODUCING POLYESTER RESIN USING THE SAME - The invention provides: a polycondensation catalyst for polyester production, which contains titanium atoms, alkaline earth metal atoms and phosphorus atoms, has high reactivity and excellent long-term storage stability, can be easily produced industrially, and has an advantage in cost; a polyester resin obtained with the catalyst; and a molded article. These are: a polymerization catalyst for polyester production containing titanium atoms, alkaline earth metal atoms and phosphorus atoms and having a specific constitution; a polyester resin obtained with the catalyst; and a molded article. | 2009-03-19 |
20090076243 | Process For Production Of Phosphate Polymer - The present invention relates to a production method including step 1 of using a specified organic hydroxy compound (1) and a phosphating agent (2) at a specified ratio and adding the phosphating agent (2) to a reaction system containing the organic hydroxy compound (1), the temperature of the reaction system is kept at 0° C. to 100° C. from the start to the end of the addition of the phosphating agent (2), and step (II) of using the polymerizable phosphate composition obtained in the step (I) and containing the phosphate and the polymerization inhibitor in such a condition that they are heated to a predetermined temperature to undergo a polymerization reaction to obtain a phosphate polymer. | 2009-03-19 |
20090076244 | Beta Helical Peptide Structures Stable in Aqueous and non-Aqueous Media and Methods for preparing same - Disclosed is a method of making peptide structures that are stable in aqueous and non-aqueous media where a first linear peptide chain comprising alternating | 2009-03-19 |
20090076245 | HIV-1 Subtype Isolate Regulatory/Accessory Genes, and Modification and Derivatives Thereof - The invention describes HIV-1 subtype isolate regulatory/accessory genes, and modifications and derivatives thereof. The genes which are described are the tat, nef and rev genes. Consensus amino acid sequences are also disclosed. The invention also relates to a vaccine including two or more of the nucleotide sequences, and nucleotide sequences from the pol and/or gag genes of HIV-1. | 2009-03-19 |
20090076246 | MODULATION OF EXON RECOGNITION IN PRE-MRNA BY INTERFERING WITH THE SECONDARY RNA STRUCTURE - The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA thereof. Further provided are methods for altering the secondary structure of an mRNA to interfere with splicing processes and uses of the oligonucleotides and methods in the treatment of disease. Further provided are pharmaceutical compositions and methods and means for inducing skipping of several exons in a pre-mRNA. | 2009-03-19 |
20090076247 | HIGH PRESSURE REFOLDING OF MONOCLONAL ANTIBODY AGGREGATES - Methods for refolding antibodies, particularly monoclonal antibodies, from aggregated and/or denatured preparations by subjecting the antibody preparation to high hydrostatic pressure are provided. Refolded preparations of antibodies produced by the methods described herein are also provided. | 2009-03-19 |
20090076248 | Plus end-directed microtubule motor required for chromosome congression - The invention provides isolated nucleic acid and amino acid sequences of | 2009-03-19 |
20090076249 | Antibodies against CD38 for treatment of multiple myeloma - Isolated human monoclonal antibodies which bind to human CD38, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the human antibodies, and therapeutic and diagnostic methods for using the human antibodies. | 2009-03-19 |
20090076250 | Substance that Specifically Recognizes PD-1 - Compounds that can recognize selectively both PD-1 protein and a membrane protein co-existing with PD-1 on a cell membrane, and can transmit a suppressive signal of PD-1. The compounds are useful for medical treatment and/or prevention of diseases caused by immune abnormality. | 2009-03-19 |
20090076251 | FcGammaRIIB Specific Antibodies and Methods of Use Thereof - The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, more particularly the extracellular domain of FcγRIIB with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA, and block the Fc binding site of FcγRIIB. The present invention also encompasses the use of an anti-FcγRIIB antibody or an antigen-binding fragment thereof, as a single agent therapy for the treatment, prevention, management, or amelioration of a cancer, preferably a B-cell malignancy, particularly, B-cell chronic lymphocytic leukemia or non-Hodgkin's lymphoma, an autoimmune disorder, an inflammatory disorder, an IgE-mediated allergic disorder, or one or more symptoms thereof. The present invention also encompasses the use of an anti-FcγRIIB antibody or an antigen-binding fragment thereof, in combination with other cancer therapies. The present invention provides pharmaceutical compositions comprising an anti-FcγRIIB antibody or an antigen-binding fragment thereof, in amounts effective to prevent, treat, manage, or ameliorate a cancer, such as a B-cell malignancy, an autoimmune disorder, an inflammatory disorder, an IgE-mediated allergic disorder, or one or more symptoms thereof. The invention further provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention with a vaccine composition. The invention further provides methods of treating cancer and/or regulating immune complex-mediated cell activation by administering the antibodies of the invention to enhance an immune response. The invention also provides methods of breaking tolerance to an antigen by administering an antigen-antibody complex and an antibody of the invention. | 2009-03-19 |
20090076252 | Continuous process for production of oil seed protein isolate - Oil seed protein isolates, particularly canola protein isolate, are produced continuously from oil seed meals, preferably at a high purity level of at least about 100 wt % (N×6.25), by a process wherein oil seed protein is continuously extracted from oil seed meal, the resulting protein solution is continuously concentrated, preferably to a protein content of at least about 200 g/L, and the concentrated protein solution is continuously mixed with chilled water having a temperature below about 15° C. to form protein micellar, which are settled in the settling vessel to provide a protein micellar mass (PMM) while supernatant overflows the vessel. The PMM, when accumulated to a desired degree, may be separated from supernatant and dried. The supernatant may be processed to recover additional oil seed protein isolate. | 2009-03-19 |
20090076253 | MACROLIDE DERIVATIVES - Compounds represented by formula (I) and the formula (IV) have an inhibitory activity of MMP-9 production, therefore, are useful as a medicine agent with fewer side effects than conventional MMP enzyme activity inhibitors, as a prophylactic and therapeutic drug for oncogenic angiogenesis, chronic rheumatoid arthritis, vascular intimal thickening after a percutaneous coronary transluminal angioplasty, vascular atherosclerosis, hemorrhagic apoplexy, acute myocardial infarction, chronic heart failure, aneurysm, lung cancer metastasis, adult respiratory distress syndrome, asthma, interstitial pulmonary fibrosis, chronic rhinosinusitis, bronchitis or chronic obstructive pulmonary disease (COPD). | 2009-03-19 |
20090076254 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF - Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HT | 2009-03-19 |
20090076255 | Nucleic acid molecules and other molecules associated with plants - Expressed Sequence Tags (ESTs) isolated from lily are disclosed. The ESTs provide a unique molecular tool for the targeting and isolation of novel genes for plant protection and improvement. The disclosed ESTs have utility in the development of new strategies for understanding critical plant developmental and metabolic pathways. The disclosed ESTs have particular utility in isolating genes and promoters, identifying and mapping the genes involved in developmental and metabolic pathways, and determining gene function. Sequence homology analyses using the ESTs provided in the present invention, will result in more efficient gene screening for desirable agronomic traits. An expanding database of these select pieces of the plant genomics puzzle will quickly expand the knowledge necessary for subsequent functional validation, a key limitation in current plant biotechnology efforts. | 2009-03-19 |
20090076256 | DEGRADATION-RESISTANT MONONUCLEOSIDE PHOSPHATE COMPOUNDS - The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that has been modified by attaching a degradation-resistant substituent on the terminal phosphate of a polyphosphate mononucleotide. By attaching this degradation-resistant substituent, the stability from degradation matches or exceeds those of certain dinucleotides. The mononucleoside phosphate compounds of the present invention are useful in preventing and treating epithelial tissue diseases or diseases or disorders associated with platelet aggregation. | 2009-03-19 |
20090076257 | Ester Derivatives of Hyaluronic Acid for the Preparation of Hydrogel Materials by Photocuring - The present invention relates to hyaluronic acid ester derivatives, whose carboxylic groups are partially esterified with hydroxy groups of propiophenone derivatives, to the hydrogel materials consisting of the said hyaluronic acid ester derivatives, to their preparation process by photocuring of the hyaluronic acid ester derivatives, and their use in the biomedical, sanitary and surgical fields, and in the medical field as controlled release systems for drugs. | 2009-03-19 |
20090076258 | Method for synthesizing oligosaccharides and glycosylation - The invention relates to an enzymatic method for synthesizing oligosaccharides, whereby one saccharide group of a sucrose analogue each is transferred onto an acceptor molecule, for example for glycosylating a hydroxyl compound, a saccharide, peptide, or a drug. According to the inventive method, an enzymatic synthesis of β-D-fructofuranosyl-a-D-aldopyranoside is carried out in a first step, and in a second step one of the saccharide groups is enzymatically transferred onto the acceptor molecule. | 2009-03-19 |
20090076259 | Fluoridation Process - The invention relates to an improved process for the fluoridation of sugar derivatives in which a controlled amount of water is present in the solvent. | 2009-03-19 |
20090076260 | HYDROGENATION PROCESS - The invention relates to an improved process for the production of a sugar alcohol from the corresponding sugar through catalytic hydrogenation. Especially, the invention relates to a process for reducing the interference of sugar-derived aldonic acids in the hydrogenation process by adjusting the hydrogenation conditions so that the activity of the catalyst is maintained. In one embodiment of the invention, the process of the invention is carried out by adjusting the hydrogenation temperature by starting the hydrogenation at a lower temperature and then gradually rising the temperature to the final hydrogenation temperature. In another embodiment of the invention, the process of the invention is carried out by adding small-molecular monocarboxylic acids to the hydrogenation solution. | 2009-03-19 |
20090076261 | Novel process for preparing sucrose-6-esters - A process for preparing a sucrose-6-ester, a key intermediate to sucralose. The process contains (a) reacting sucrose with a di(hydrocarbyl)tin oxide or a 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl)distannoxane in the presence of a secondary alcohol and an organic polar aprotic solvent, to prepare a mixture comprising 1,3-di-(6-O-sucrose)-1,1,3,3-tetra(hydrocarbyl)distannoxane and the secondary alcohol; and (b) adding an acylating agent to the mixture, thereby acylating the 1,3-di-(6-O-sucrose)-1,1,3,3-tetra(hydrocarbyl)distannoxane to prepare a sucrose-6-ester. | 2009-03-19 |
20090076262 | PROCESS FOR PREPARING QUETIAPINE AND QUETIAPINE FUMARATE - The invention comprises a process for preparing quetiapine and/or its salts, including, quetiapine fumarate. The process generally comprises reacting dibenzothiazepinone (dibenzo[bf][1,4]thiazepin-11(10H)-one) with phosphorous oxychloride in the presence of triethylamine in an aromatic organic solvent such as toluene or, preferably, xylene at reflux temperature to obtain an aromatic hydrocarbon solution of 11-chloro-dibenzo[bf][1,4]thiazepine. Thereafter, the 11-chloro-dibenzo[bf][1,4]thiazepine is reacted with 2-(2-piperazin-1-ylethoxy)-ethanol to yield, following several processing steps, quetiapine. Compound I can then be further reacted with fumaric acid at elevated temperature to yield quetiapine fumarate. The resulting quetiapine fumarate obtained is suitable for use in pharmaceutical preparations. | 2009-03-19 |
20090076263 | ELIMINATION OF HETEROGENEOUS OR MIXED CELL POPULATION IN TUMORS - Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor. | 2009-03-19 |
20090076264 | DEUTERIUM-ENRICHED RIVAROXABAN - The present application describes deuterium-enriched rivaroxaban, pharmaceutically acceptable salt forms thereof, and methods of treating using the same. | 2009-03-19 |
20090076265 | Method for producing melamine - The invention concerns a method for producing melamine by dissolving urea, in which solid, liquid or gaseous media other than the gas mixture consisting of the components formed during the reaction is used to desublime the melamine from the gas phase. | 2009-03-19 |
20090076266 | COPPER-CATALYZED C-H BOND ARYLATION - The present invention is a one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using a combination of aryl halides, a substrate, and a copper salt as catalyst. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores and explosives. | 2009-03-19 |
20090076267 | TRANSITION METAL PHOSPHINE COMPLEX, METHOD FOR PRODUCING SAME, AND ANTICANCER AGENT CONTAINING TRANSITION METAL PHOSPINE COMPLEX - There is provided a novel transition metal phosphine complex having excellent anticancer activity. The transition metal phosphine complex is represented by general formula (1): | 2009-03-19 |
20090076268 | Facile assembly of fused benzofuro-heterocycles - This invention concerns the synthesis of polycyclic structural components of pharmacological compounds, including the synthesis of fused benzofuro-heterocycles, through selective palladium-catalyzed cross-coupling and intramolecular cyclization. | 2009-03-19 |
20090076269 | PURINONE DERIVATIVES AS HM74A AGONISTS - The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease. | 2009-03-19 |
20090076270 | Drying process for preparing crystalline solid famciclovir - The present invention provides a drying process for preparing crystalline solid famciclovir form I comprising the steps of: i) preparing a wet crystalline form of famciclovir; ii) drying the wet crystalline form of famciclovir at a temperature of below 50° C. until the crystalline form contains less than 15% (wt/wt) wetness; and iii) drying the wet crystalline form of famciclovir at a temperature of above 50° C. until the wet crystalline form of famciclovir contains less than 0.05% (wt/wt) water to obtain crystalline solid famciclovir form I. | 2009-03-19 |
20090076271 | Process for preparing intermediates of HMG-CoA reductase inhibitors - The present invention relates to intermediates of rosuvastatin and processes for the production thereof. | 2009-03-19 |
20090076272 | Polymorphs of eszopiclone malate - The present invention provides crystalline Eszopiclone malate form II, crystalline Eszopiclone form V, processes from preparing the crystalline Eszopiclone malate form II or V, pharmaceutical compositions comprising the crystalline Eszopiclone malate form II or V and methods of treating insomnia comprising administering the crystalline Eszopiclone malate form II or V. | 2009-03-19 |
20090076273 | SOLUBLE AMIDE & ESTER PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS - The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers. | 2009-03-19 |
20090076274 | BENZOXAZINONE DERIVATIVES, PREPARATION THEREOF AND USES IN THE TREATMENT OF CNS AND OTHER DISORDERS - Intermediates useful in the preparation of compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: | 2009-03-19 |
20090076275 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS - Provided herein are compounds of the formula (I): | 2009-03-19 |
20090076276 | ISOQUINOLINE COMPOUND AND PHARMACEUTICAL USE THEREOF - The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and/or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction. | 2009-03-19 |
20090076277 | Process for the preparation of pyridine-methylsulfinyl compounds - A process for the preparation of a compound of formula (I), or a salt thereof, | 2009-03-19 |
20090076278 | METHINE DYES AND USES OF THE SAME - The present invention provides novel organic compounds, which absorb the light in the ultra violet and the infrared regions, have improved light tolerance and solubility in solvents, and have thermal tolerance suitable for uses to which the organic compounds are applied, and provides uses of the same. The above objects are solved by providing indolenine compounds and methine dyes, which have a bis-indolenine skeleton composed of two indolenine rings linked together at their respective C-3 positions via a divalent linking group, and by providing optical recording media containing the methine dyes. | 2009-03-19 |
20090076279 | REACTION PRODUCTS OF MERCAPTOBENZOTHIAZOLES, MERCAPTOTHIAZOLINES, AND MERCAPTOBENZIMIDAZOLES WITH EPOXIDES AS LUBRICANT ADDITIVES - A composition comprising:
| 2009-03-19 |
20090076280 | PROCESSES FOR PRODUCTION OF OPTICALLY ACTIVE PPAR-ACTIVATING COMPOUNDS AND INTERMEDIATES FOR PRODUCTION THEREOF - The invention provides a process for producing an optically active butyric acid compound and a production intermediate therefor at high yield and high purity. | 2009-03-19 |
20090076281 | PROCESS FOR THE PREPARATION OF LOSARTAN AND ITS SALTS - The invention relates to the preparation of losartan and losartan potassium. More particularly, the invention relates to the preparation of losartan and losartan potassium in a simplified process that provides higher purity losartan potassium and losartan potassium having larger crystal sizes. The invention further includes formulating into readily usable dosage units for the therapeutic treatment (including prophylactic treatment) of mammals, including humans. | 2009-03-19 |
20090076282 | 3-TRIAZOLYLPHENYL SULFIDE DERIVATIVE AND INSECTICIDE/ACARICIDE/NEMATICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT - To provide novel 3-triazolylphenyl sulfide derivatives having excellent soil treatment activity as insecticides, miticides or nematicides for agricultural and horticultural plants. | 2009-03-19 |
20090076283 | Method of crystallizing carvedilol phosphate and the product thereof - The present invention provides for a crystalline polymorph of Carvedilol phosphate salt and a process for making the same. | 2009-03-19 |
20090076284 | PROCESS FOR CONTINUOUSLY REMOVING A TARGET PRODUCT X IN THE FORM OF FINE CRYSTALS - A process for continuously removing a target product X in the form of fine crystals from a liquid phase P comprising the target product X and constituents other than the target product X by cooling suspension crystallization in the secondary chamber, into which the liquid phase P flows continuously, of an indirect heat exchanger with simultaneous continuous flow of a coolant through the primary chamber of the indirect heat exchanger and continuous withdrawal of a crystal suspension S having a degree of crystallization Y from the secondary chamber, in which the degree of crystallization Y is adjusted on the basis of a heat balance conducted continuously with the aid of a process computer. | 2009-03-19 |
20090076285 | PROCESS FOR THE TREATMENT OF AN AQUEOUS MIXTURE COMPRISING A DIPOLAR APROTIC COMPOUND - The invention relates to a process for the treatment of an aqueous mixture comprising a dipolar aprotic compound, comprising: a) an adsorption step, in which the aqueous mixture is brought into contact with a porous adsorbent, whereby the porous adsorbent is chosen such that the dipolar aprotic compound adsorbs to it more readily than water; b) a desorption step, in which the porous adsorbent is brought into contact with a desorbing agent, whereby a recovery solution is formed comprising the desorbing agent and the dipolar aprotic compound. | 2009-03-19 |
20090076286 | PROCESS FOR OPERATING A CONTINUOUS REMOVAL OF A TARGET PRODUCT X IN THE FORM OF FINE CRYSTALS - A process for continuously removing a target product X in the form of fine crystals from a liquid phase P comprising the target product X and constituents other than the target product X by cooling suspension crystallization in an indirect heat transferee, in which the crystal suspension formed is conducted out of the heat transferer first into a mixed buffer tank and, from there, fed to an apparatus for separating the crystal suspension into crystals and liquid phase, and wherein external measures dissipade the oversaturation of the crystal suspension fed to the buffer vessel with target product X. | 2009-03-19 |
20090076287 | METHOD OF OBTAINING DERIVATIVES OF 4-(N-ALKYLAMINE)-5,6-DIHYDRO-4H-THIENO-[2,3-B]-THIOPYRAN - The invention is aimed at a compound of formula (I) wherein n is 0, 1 or 2, R | 2009-03-19 |
20090076288 | PROCESS FOR ISOLATION OF DESIRED ISOMERS OF NEBIVOLOL INTERMEDIATES - The present invention relates to a simple and commercially viable process for separation of desired isomers of nebivolol intermediates from a mixture containing undesired isomers of nebivolol intermediates. Thus, (+)-[2R*[1S*,5S*(S*)]]+[2R*[1S*,5R*(R*)]]-α,α′-[phenylmethyliminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] is dissolved in diisopropyl ether at reflux temperature and cooled to below about 30° C. to obtain the desired (+)-[2R*[1S*,5S*(S*)]]-α,α′-[phenylmethyliminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]. | 2009-03-19 |
20090076289 | Methods of Making Epothilones - The invention provides novel compounds that may be used as intermediates in the preparation of epothilones, epothilone analogs and derivative, as well as new synthetic methods for producing the intermediates and products. | 2009-03-19 |
20090076290 | SELECTIVE OXIDATION OF TRITERPENES EMPLOYING TEMPO - The present invention provides a process of preparing betulin-28-aldehyde from betulin. The process includes contacting betulin with a compound of formula (I), e.g., TEMPO (2,2,6,6-tetramethylpiperidine 1-oxyl) for a period of time effective to provide betulin-28-aldehyde. The present invention also provides a process of preparing betulinic acid. The process includes contacting betulin with a composition that includes: sodium hypochlorite (NaOCl); sodium chlorite (NaClO | 2009-03-19 |
20090076291 | PHOTOACTIVE ADHESION PROMOTER - An adhesion promoter to help reduce semiconductor process effects, such as undesired line edge roughness, insufficient lithographical resolution, and limited depth of focus problems associated with the removal of a photoresist layer. A photoactive adhesion promoter (PAG) is described which helps reduce these and other undesired effects associated with the removal of photoresist in a semiconductor manufacturing process. | 2009-03-19 |
20090076292 | Rosuvastatin intermediates and process for the preparation of rosuvastatin - Provided are intermediates and process for the preparation of statins, preferably rosuvastatin. | 2009-03-19 |
20090076293 | PROCESSES FOR PREPARING DIARYL AND/OR ALKYLARYL CARBONATES FROM DIALKYL CARBONATES - Processes comprising: reacting a dialkyl carbonate and an aromatic hydroxy compound in the presence of a transesterification catalyst in a first reaction column, the first reaction column comprising a top section, a bottom section, a rectifying section in an upper portion of the column and a reaction zone below the rectifying section; feeding a bottom product from the first reaction column to a further reaction column; the bottom product comprising a diaryl carbonate, an alkylaryl carbonate, or both, and residual unreacted dialkyl carbonate and aromatic hydroxy compound; the further reaction column comprising a top section, a rectifying section in an upper portion of the column and a reaction zone below the rectifying section; and reacting the residual reacted dialkyl carbonate and aromatic hydroxy compound in the further reaction column; feeding a process stream to a distillation column, the process stream comprising a mixture of unreacted dialkyl carbonate and one or more reaction-product alcohols drawn from the first reaction column, the further reaction column, or both, such that the unreacted dialkyl carbonate is separated from the one or more reaction-product alcohols; and recycling the separated, unreacted dialkyl carbonate to the first reaction column; wherein the further reaction column comprises one or more condensers, and heat of condensation from the one or more condensers is fed back into the process. | 2009-03-19 |
20090076294 | CONTROLLED NUCLEATION OF SOLUTES IN SOLUTIONS HAVING NET CHARGE TO PROMOTE CRYSTAL GROWTH - This application is concerned with the controlled nucleation of solutes (i.e. dissolved solids) from solution. It has been found that the energy barrier for dissolved solids to nucleate is affected by the surface charge density of the reaction vessel (and hence the mass-to-charge ratio of vessel). The reaction vessel may, for example, comprise a levitated droplet of the solution having an “excess net charge”. That is, ions present in the vessel of a single polarity are in excess of the counterions of opposite polarity. An increase in the surface charge density of the vessel (and hence a reduction in the mass-to-charge ratio of the vessel) causes the barrier for nucleation to decrease. These findings can be exploited using instruments commonly used in wall-less sample preparation to elicit selective control over the induction of nucleation and subsequent crystallization of target solutes of interest in the condensed phase. The ion induced nucleation phenomenon, in reaction vessels having a desirable surface charge density, is likely to be general for all dissolved solids, ranging from inorganic compounds, to low and high molecular weight organic compounds, including proteins and other molecules. For example the present invention can be used to selectively crystallize a target solute or to separate different solutes from one another based on their propensity to nucleate at different reaction conditions. The different solutes could constitute different compounds or different stereochemical forms of same compound. The invention could also be exploited to controllably select or separate polymorphic forms of a compound (which may often have very different biological activity). The crystals derived from the process could be the subject of further analysis, characterization or manipulation, for example as a prepared sample for MALDI-TOF MS. | 2009-03-19 |
20090076295 | PHOTOCLEAVABLE PROTECTING GROUPS - Novel compounds are provided, which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally photolabile and comprise protecting groups which can be removed by photolysis to unmask a reactive group. The protecting group has the general formula Y, wherein Y is a chemical structure as shown in FIG. | 2009-03-19 |
20090076296 | Preparation of oseltamivir phosphate - The invention provides a new process for the conversion of shikimic acid to oseltamivir (I), and optionally to an acid addition salt, via the intermediate phosphoramide VII. | 2009-03-19 |
20090076297 | Process for converting a hydroxycarboxylic acid, or salts thereof, to an unsaturated carboxylic acid and/or its esters - A process for converting a salt of a hydroxycarboxylic acid to an unsaturated carboxylic acid, or esters thereof. The process involves converting an ammonium salt of a hydroxycarboxylic acid in aqueous solution to a corresponding hydroxycarboxylic acid and ammonium cation in aqueous solution; and separating the ammonium cation from the aqueous solution, leaving the hydroxycarboxylic acid in aqueous solution. The converting and separating steps may be accomplished by employing a hydrophobic acid or an acid ion exchange resin, each of which must have an acid dissociation constant, i.e., pK | 2009-03-19 |
20090076298 | Utilization of acetic acid reaction heat in other process plants - Integrated processes and systems for producing acetic acid and vinyl acetate are provided. In the processes and systems, a portion of the heat produced during the production of the acetic acid is transferred to the vinyl acetate production and/or purification process and system to facilitate production and/or purification of the vinyl acetate product. The process and systems described herein are useful in conjunction with any of the various known processes for the production of acetic acid and vinyl acetate. The heat of the acetic acid production reaction may be transferred to the vinyl acetate production system by any suitable heat transfer processes and systems. The heat may be provided to the purification section at a variety of locations in the vinyl acetate production and purification systems, depending on the specific configuration of the system to which the processes and systems. The process and systems described herein are useful to provide cost and energy savings in vinyl acetate production processes. | 2009-03-19 |
20090076299 | PHOSPHATED ALCANOL, ITS USE AS A HYDROTROPE AND CLEANING COMPOSITION CONTAINING THE COMPOUND - The present invention relates to the use of phosphated 2-propylheptanol or a phosphated 2-propylheptanol alkoxylate as a hydrotrope in aqueous alkaline solutions for a C | 2009-03-19 |
20090076300 | METHOD FOR IMMOBILIZING COMPOUND ONTO COLUMN CARRIER - It is intended to provide a method for immobilizing, onto a column carrier, a compound having a sulfo group or a compound to which a sulfo group can be added. The method comprises immobilizing the compound onto the column carrier using a linker comprising: a sulfo group-binding group capable of forming a bond with the sulfo group in the compound; and a carrier-binding group capable of forming a bond with a group present on the surface of the column carrier. | 2009-03-19 |
20090076301 | METHODS FOR PRODUCING NATEGLINIDE CRYSTALS - There is provided methods for producing nateglinide crystals, which comprises the steps of adding an acid(s) to a reaction mixture containing nateglinide to make it acidic, the reaction mixture being obtained by reacting trans-4-isopropylcyclohexylcarbonyl chloride with D-phenylalanine in a mixed solvent of ketone solvent and water in the presence of an alkali; and then adjusting the temperature of the mixture to 58° C. to 72° C. and the concentration of ketone solvent to more than 8 wt % and less than 22 wt % to conduct precipitation of nateglinide crystals. This producing method is the industrially beneficial methods for crystallization of nateglinide. | 2009-03-19 |
20090076302 | PROCESS FOR PREPARING a-KETO ACIDS AND DERIVATIVES THEREOF - A method for preparing α-keto acids, especially α-ketomethionine, and/or derivatives thereof, whereby an aldehyde is reacted with thiols to give a corresponding dithioacetal, the dithioacetal formed, is reacted with an electrophile in the presence of a strong base, and the resulting α,α-(dithio)carboxylic acid is solvolyzed with acid-catalysis to release thiol and give the α-keto acid or a derivative thereof. Umpolung of aliphatic or aromatic aldehydes is effected by reaction with thiols. | 2009-03-19 |
20090076303 | Process for selective reduction of propionic acid from (meth)acrylic acid product streams - The present invention relates to an improved process for the selective reduction of propionic acid, hereinafter “PA”, impurity from an acrylic acid, hereinafter “AA” stream. | 2009-03-19 |
20090076304 | METHODS FOR PRODUCING CARBOXYLIC ACID CHLORIDE COMPOUNDS - The present invention discloses methods for producing a carboxylic acid chloride compound which comprises the step of reacting an alkyl-substituted cyclohexyl carboxylic acid with a chlorinating agent in the presence of a specific urea compound. According to this invention, it is possible to produce a carboxylic acid chloride compound which has high reaction speed, and whose product has high purity or high yield. Thus produced carboxylic acid chloride compound is useful as an intermediate for producing D-phenylalanine derivatives which are used as agents for treating diabetes. | 2009-03-19 |
20090076305 | METHOD FOR PRODUCING HYDRAZONE DERIVATIVES - The present invention provides an industrially advantageous process for producing hydrazone derivative represented by the formula (5), which is shown by the following reaction formula. | 2009-03-19 |
20090076306 | PROCESS FOR CONTINUOUS PREPARATION OF A PRIMARY AROMATIC AMINE - A process for continuously preparing a primary aromatic amine by reacting a corresponding cycloaliphatic alcohol with ammonia in the presence of hydrogen at a temperature in the range from 80 to 350° C. in the presence of a heterogeneous catalyst, wherein the catalytically active composition of the catalyst, before its reduction with hydrogen, comprises
| 2009-03-19 |
20090076307 | Aromatic diamine compound and aromatic dinitro compound - A novel aromatic diamine compound obtained by introducing aromatic amino groups into both terminals of a specific bifunctional phenylene ether oligomer and a novel aromatic dinitro compound obtained by introducing aromatic nitro groups into both terminals of a specific bifunctional phenylene ether oligomer, these compounds being used as raw materials for obtaining high molecular weight materials having high heat resistance, a low dielectric constant, a low dielectric loss tangent and a low water absorption coefficient. | 2009-03-19 |
20090076308 | Method For Oxidizing Saturated Cyclic Hydrocarbons By Oxygen - The present invention relates to a continuous method for oxidizing saturated cyclic hydrocarbons by oxygen to obtain a mixture of hydroperoxides, alcohols and ketones. It relates more particularly to a method for oxidizing cyclohexane in a column forming a bubble reactor, for the formation of cyclohexyl hydroperoxide, cyclohexanol and cyclohexanone. According to the invention, the column may be supplied with oxygen-enriched air, while meeting the maximum oxygen concentration requirements in the headspace of the reactor to avoid any risk of explosion. | 2009-03-19 |
20090076309 | Alpha-Ketol Unsaturated Fatty Acid Derivative And Plant Growth Regulating Agent Using Same - An α-ketol unsaturated fatty acid derivative represented by the formula (1): | 2009-03-19 |
20090076310 | NOVEL BIS-(HYDROXYBENZALDEHYDE) COMPOUND AND NOVEL POLYNUCLEAR POLYPHENOL COMPOUND DERIVED THEREFROM AND METHOD FOR PRODUCTION THEREOF - Provide a new bis-(hydroxybenzaldehyde) compound, as well as a new polynuclear polyphenol compound derived therefrom, suitable for use as component materials for photosensitive resist compositions, component materials and hardeners for epoxy resins, developers and anti-fading agents used in thermosensitive recording materials, bactericides, fungicides, antioxidants and other functional chemical products or component materials thereof, wherein such bis-(hydroxybenzaldehyde) compound is produced by reacting in the presence of trihalogenated acetic acid catalyst or phosphoric acid catalyst a 2,6-di(hydroxymethyl)-4-alkylphenol with a hydroxybenzaldehyde expressed by general formula (14). | 2009-03-19 |
20090076311 | PROCESS FOR PRODUCING ALDEHYDE WITH 2-POSITION BRANCHED LONG-CHAIN ALKYL - To provide a process capable of producing an aldehyde with a 2-position branched long-chain alkyl with high yield and high selectivity. The process for producing an aldehyde with a 2-position branched long-chain alkyl represented by the following general formula (2) contains: using a 2-position branched epoxide represented by the following general formula (1) as a raw material; and subjecting the epoxide to acid rearrangement reaction with a polyacid of a metallic oxoacid as a catalyst. In the formulae, n represents an integer of from 5 to 17. | 2009-03-19 |
20090076312 | PROCESS FOR THE CONVERSION OF TERTIARY BUTYL ALCOHOL TO ETHYL TERTIARY BUTYL ETHER - A process for the conversion of tertiary butyl alcohol to ethyl tertiary butyl ether, including: dehydrating tertiary butyl alcohol to form a product stream comprising isobutylene and water; separating the product stream to form an isobutylene-rich fraction and a water-rich fraction; separating the water-rich fraction to recover a hydrocarbon fraction and a water fraction having less than 1 ppm hydrocarbon content; reacting isobutylene in the isobutylene-rich fraction with ethanol to form a reaction product comprising ethyl tertiary butyl ether; separating the reaction product to recover unreacted ethanol and an ethyl tertiary butyl ether stream; and recycling at least a portion of the unreacted ethanol to the reacting; wherein the ethyl tertiary butyl ether stream comprises at least 99 weight percent ethyl tertiary butyl ether. | 2009-03-19 |
20090076313 | SUBSTITUTED 1-(2-ETHYL-1-METHYL-CYCLOPROPYL)-ONE/OL DERIVATIVES - The present invention is directed to novel ketone and alcohol compounds and the use of these novel compounds in creating fragrances and scents in items such as perfumes, colognes and personal care products. | 2009-03-19 |
20090076314 | Bisphenol compound and process for preparation thereof - The present invention provides a novel bisphenol compound of formula (I). | 2009-03-19 |
20090076315 | PROCESS FOR THE PREPARATION OF SUBSTITUTED FLUORENES - Methods for the preparation of fluorenyl-type ligand structures and substituted fluorenyl groups which may be employed in metallocene-type olefin polymerization catalysts. There is provided a 2,2′-dihalogen-diphenylmethylene having a methylene bridge connecting a pair of phenyl groups. Each phenyl group has a halogen on a proximal carbon atom relative to the methylene bridge. The halogenated diphenylmethylene is reacted with a coupling agent comprising a Group 2 or 12 transition metal in the presence of a nickel or palladium-based catalyst to remove the halogen atoms from the phenyl groups and couple the phenyl groups at the proximal carbon atoms to produce a fluorene ligand structure. The coupling agent may be zinc, cadmium or magnesium and the catalyst may be a monophosphene nickel complex. The halogenated diphenylmethylene may be an unsubstituted ligand structure or a monosubstituted or disubstituted ligand structure. The halogenated diphenylmethylene may be monosubstituted with a tertiary butyl group or may be a dialkyl diphenylmethylene having alkyl substituents at the directly distal positions of the phenyl groups relative to the methylene bridge. | 2009-03-19 |
20090076316 | PROCESS FOR PRODUCTION OF AROMATIC HYDROCARBON - A process for producing an aromatic hydrocarbon, comprises heating the hydrocarbon in the presence of a catalyst carrying a molybdenum compound or a rhenium compound on a metallosilicate carrier modified with a silicon compound, a sodium compound or a calcium compound. The silicon compound is a silane compound having a basic group selected from amino, alkylamino and pyridyl groups and an organic group of a size equal to or greater than the pore size of the metallosilicate and selected from trialkoxy and triphenyl groups and the sodium compound or the calcium compound is a compound having an organic group of a size equal to or greater than the pore size of the metallosilicate and selected from crown ether, hexafluoropentanedione and acetylacetonate. The silane compound, the sodium compound or the calcium compound is modified so as to make an oxide thereof by impregnating the metallosilicate carrier with it and subsequently heat-treating it in an oxygen-containing atmosphere. | 2009-03-19 |
20090076317 | Synthesis of high activity ZSM-48 - A process for producing ZSM-48 comprises crystallizing an aqueous reaction mixture comprising at least one source of silica, at least one source of alumina, at least one source of hydroxyl ions, at least one source of diquaternary alkylammonium, R | 2009-03-19 |