12th week of 2020 patent applcation highlights part 27 |
Patent application number | Title | Published |
20200087563 | INVERT EMULSION DRILLING FLUIDS WITH FATTY ACID AND FATTY DIOL RHEOLOGY MODIFIERS - Provided here are various invert emulsion drilling fluid compositions. The invert emulsion fluid is a water in oil emulsion, which can include an invert emulsifier to stabilize the water in oil emulsion, a 16 to 18 carbon carboxylic acid, a 36 carbon fatty dimer diol, a polymeric filter control agent, and an inorganic mineral including one or more of lime, calcium chloride, and barite. The invert emulsion drilling fluids can be formulated to be substantially free of clay. | 2020-03-19 |
20200087564 | CAPSULE DESIGN FOR THE CAPTURE OF REAGENTS - A method of using a gas control additive to provide gas migration control in a wellbore includes the steps of mixing the gas control additive with a cement to form a cement slurry, where the gas control additive includes a semi-permeable membrane and a scrubbing agent, such that the semi-permeable membrane forms a shell around a core such that the scrubbing agent is in the core, introducing the cement slurry to the wellbore, and reacting the scrubbing agent with an antagonistic gas to produce a helper byproduct, where the antagonistic gas migrates from a hydrocarbon-bearing formation into the wellbore and permeates through the semi-permeable membrane to the core of the gas control additive. | 2020-03-19 |
20200087565 | CAPSULE DESIGN FOR THE CAPTURE OF REAGENTS - A method of using a gas control additive to provide gas migration control in a wellbore includes the steps of mixing the gas control additive with a cement to form a cement slurry, where the gas control additive includes a semi-permeable membrane and a scrubbing agent, such that the semi-permeable membrane forms a shell around a core such that the scrubbing agent is in the core, introducing the cement slurry to the wellbore, and reacting the scrubbing agent with an antagonistic gas to produce a helper byproduct, where the antagonistic gas migrates from a hydrocarbon-bearing formation into the wellbore and permeates through the semi-permeable membrane to the core of the gas control additive. | 2020-03-19 |
20200087566 | POLYAROMATIC HYDROCARBON ADDITIVES FOR HYDRATE INHIBITION - Methods involving anti-agglomerant hydrate inhibitors and polyaromatic hydrocarbons for hydrate inhibition are provided. In some embodiments, the methods include introducing a hydrate inhibitor composition including an anti-agglomerant hydrate inhibitor into a fluid including (i) water and (ii) one of gas, liquid hydrocarbon, and any combination thereof; and introducing a polyaromatic hydrocarbon into the fluid. | 2020-03-19 |
20200087567 | METHOD TO GENERATE ACIDIC SPECIES IN WELLBORE FLUIDS - Certain sugars, when exposed to high temperatures, undergo oxidation to produce acidic species. Certain sugar alcohols are also acid precursors. The acidification process is a function of temperature, salinity, pH, and/or the presence of an agent, such as an accelerator or a retarder. The rate of acidification may be controlled within a filter cake breaker fluid in order to achieve a predetermined fluid pH after a selectable period of time. The time controllable nature of the acidification allows the development of filter cake breaker fluids with an engineered activity delay. | 2020-03-19 |
20200087568 | METHOD FOR REMOVING IRON SULFIDE AND CALCIUM CARBONATE SCALE - A method of removing a heterogeneous scale from a surface in fluid communication with a wellbore and/or subterranean formation comprising contacting the scale with a composition comprising tetrakis(hydroxmethyl)phosphonium sulfate (THPS) and N-( | 2020-03-19 |
20200087569 | SURFACTANT COMPOSITION AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF - This invention relates to a surfactant composition, production and use thereof in tertiary oil recovery. The present surfactant composition comprises a cationic-nonionic surfactant and an anionic surfactant, and exhibits significantly improved interfacial activity and stability as compared with the prior art. With the present surfactant composition, a flooding fluid composition for tertiary oil recovery with improved oil displacement efficiency and oil washing capability as compared with the prior art could be produced. | 2020-03-19 |
20200087570 | SURFACTANT COMPOSITION AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF - This invention relates to a surfactant composition, production and use thereof in tertiary oil recovery. The present surfactant composition comprises a cationic-nonionic surfactant and an anionic surfactant, and exhibits significantly improved interfacial activity and stability as compared with the prior art. With the present surfactant composition, a flooding fluid composition for tertiary oil recovery with improved oil displacement efficiency and oil washing capability as compared with the prior art could be produced. | 2020-03-19 |
20200087571 | Excapsulation oxidizing breakers for downhole applications - A variety of systems, methods and compositions are disclosed. A method may comprise introducing a fracturing fluid into a subterranean formation, wherein the fracturing fluid comprises an aqueous based fluid, a proppant composition, an oxidizing breaker, and halloysite nanotubes, wherein the oxidizing breaker is positioned within the halloysite nanotubes; and reducing a viscosity of the fracturing fluid. | 2020-03-19 |
20200087572 | SEMICONDUCTING LIGHT EMITTING NANOPARTICLE - The present invention relates to a semiconducting light emitting nanoparticle; a process for synthesizing a semiconducting light emitting nanoparticle; composition, formulation and use of a semiconducting light emitting nanoparticle, an optical medium; and an optical device. | 2020-03-19 |
20200087573 | PHASE DIFFERENCE PLATE FOR ORGANIC EL DISPLAY DEVICE, ORGANIC EL DISPLAY DEVICE, AND METHOD FOR PRODUCING PHASE DIFFERENCE PLATE - An object of the present invention is to provide a phase difference plate for an organic EL display device having excellent light resistance, an organic EL display device, and a method for producing a phase difference plate. The phase difference plate for an organic EL display device of an embodiment of the present invention has a phase difference layer formed from a composition containing a polymer having a repeating unit A including a photo-alignment group and a polymerizable liquid crystal compound having reciprocal wavelength dispersion, in which the photo-alignment group includes a double bond structure of C═C or C═N. | 2020-03-19 |
20200087574 | PYROLYSIS SYSTEM WITH OPTIMIZED REACTION SEQUENCING - Systems and methods for processing pyrolyzable materials in order to recover one or more usable end products are provided. Pyrolysis methods and systems according to various aspects of the present invention are able to thermally decompose carbon-containing materials, including, for example, tires and other rubber-containing materials, in order recover hydrocarbon-containing products including synthesis gas, pyrolysis oil, and carbon black. Systems and methods according to aspects of the present invention may be successful on a commercial scale, and may be suitable for processing a variety of feedstock including, but not limited to, used tires and other types of industrial, agricultural, and consumer waste materials. | 2020-03-19 |
20200087575 | METHOD AND SYSTEM FOR PROCESSING OIL SANDS AND OTHER MATERIALS WITH LOW ENVIRONMENTAL IMPACTS - A method of processing a first material including an oil source, and a second material including a medium. The method includes mixing the first material and the second material to provide a blended feedstock mixture including predetermined respective proportions of the first material and the second material, and also including water. The blended feedstock mixture is heated in a pre-distillation process and is further heated in a distiller to at least partially crack and vaporize the oil source, to provide atmospheric gas oil and vacuum gas oil from the oil source, coked medium material including carbon-heavy hydrocarbons and sand, and a first barren hot medium material. The coked medium material is heated in a gasifier to provide a second barren hot medium material and syngas. Heat energy from certain products resulting from such heating is transferred to the blended feedstock mixture. | 2020-03-19 |
20200087576 | PROCESSES AND CATALYSTS FOR REFORMING OF IMPURE METHANE-CONTAINING FEEDS - Processes and catalysts for producing hydrogen by reforming methane are disclosed, which afford considerable flexibility in terms of the quality of the reformer feed. This can be attributed to the robustness of the noble metal-containing catalysts described herein for use in reforming, such that a number of components commonly present in methane-containing process streams can advantageously be maintained without conventional upgrading (pretreating) steps, thereby improving process economics. This also allows for the reforming of impure reformer feeds, even in relatively small quantities, which may be characterized as complex gas mixtures due to significant quantities of non-methane components. A representative reforming catalyst comprises 1 wt-% Pt and 1 wt-% Rh as noble metals, on a cerium oxide support. | 2020-03-19 |
20200087577 | Process for Hydroprocessing of Non-Petroleum Feedstocks - A method of hydroprocessing is performed wherein non-petroleum feedstocks, such as those containing from about 10% or more olefinic compounds or heteroatom contaminants by weight, are treated in a first reaction zone to provide reaction products. The process involves introducing the feedstock along with diluents or a recycle and hydrogen in a first reaction zone and allowing the feed and hydrogen to react in a liquid phase within the first reaction zone to produce reaction products. The reaction products are cooled and/or water is removed from the reaction products. At least a portion of the cooled and/or separated reaction product are introduced as a feed along with hydrogen into a second reaction zone containing a hydroprocessing catalyst. The feed and hydrogen are allowed to react in a liquid phase within the second reaction zone to produce a second-reaction-zone reaction product. | 2020-03-19 |
20200087578 | PRODUCTION OF A FUEL COMPOSITION - The present invention relates to a method for production of a fuel composition, more specifically a middle distillate fuel composition, and a composition—in particular a co feed composition comprising a furanyl containing oligomerisation composition admixed with one or more material component comprising fatty acids or fatty acid derivatives and the use of such composition. | 2020-03-19 |
20200087579 | METHOD, APPARATUS, AND SYSTEM FOR PROVIDING AN INTEGRATED BIOENERGY COMPLEX TO PROCESS MIXED SOLID WASTE - An approach is provided for processing mixed solid waste using an integrated bioenergy complex. The approach, for instance, involves receiving the mixed solid waste at the integrated bioenergy complex, the integrated bioenergy complex including an organic conversion processing center and an inorganic conversion processing center. The approach also involves separating the mixed solid waste into recyclables, an organic waste stream, and an inorganic waste stream. The approach further involves feeding the organic waste stream to the organic conversion processing center to produce organic conversion products and an organic residual, and feeding the organic residual and the inorganic waste stream to the inorganic conversion processing center to produce inorganic conversion products, electric power, and a residual waste. The electric power is used to partially or fully power the organic conversion processing center, and residual waste is less than a target percentage of the received mixed solid waste. | 2020-03-19 |
20200087580 | TUBE ARRANGEMENT AND FURNACE - A tube arrangement comprising a first metal tube, a second metal tube, a first sleeve part, and a second sleeve part. The first and second sleeve parts are threadedly connected to the first and second metal tubes. The first and second metal tubes are configured to be joined via a butt weld joint. The first sleeve and the second sleeve are configured to be joined via a second butt weld joint. The first sleeve part comprises a first outer surface extending at a first acute angle (α) to an axial centre axis of the first sleeve part and the second sleeve part comprises a second outer surface extending at a second acute angle (β) to an axial centre axis of the second sleeve part. The present disclosure also relates to a furnace. | 2020-03-19 |
20200087581 | HAZE-FREE BASE OILS WITH HIGH PARAFFINIC CONTENT - The present invention relates to a method for reducing the cloud point of a base oil with high saturates/paraffinic content to below 0° C., wherein the method comprises subjecting said base oils to a cloud point reduction step comprising adding said base oil to a solvent mixture, wherein the solvent mixture comprises a paraffin naphtha fraction and a co-solvent to obtain a solvent treatment mixture; and subjecting the solvent treatment mixture to a solvent de-waxing step. | 2020-03-19 |
20200087582 | METHOD OF TREATING A HYDROCARBON STREAM - A method of treating a hydrocarbon stream includes: withdrawing an effluent stream comprising hydrocarbons and polymer from a reactor; contacting the effluent stream with a coolant stream; passing the effluent stream through a heat exchanger; wherein after passing the effluent stream through the heat exchanger, the heat exchanger is substantially free of polymer deposits. | 2020-03-19 |
20200087583 | Radiofrequency Pump Inlet Electric Heater - An apparatus, method and system make possible facile recovery of heavy hydro-carbonaceous materials, such as the bitumen from oil sands, asphalt, tars, pitch and other highly viscous hydrocarbons (HCM) from natural deposits of such material and other storage facilities such as tanks and reservoirs where these materials accumulate. The apparatus and system deliver different inputs of radio frequency energy (RF) to a central collector and one or more outer electrodes. Heat generated by the RF input sufficiently softens the HCM so that a suction pump can withdraw if from the collector and deliver it to a desired location typically for transport and/or processing. The addition of an integral mixer or direct injection of solvents into the apparatus can further improve HCM recovery. | 2020-03-19 |
20200087584 | METHODS FOR SEPARATING LIGHT FRACTIONS FROM HYDROCARBON FEEDSTOCK - A process for facile separation of lighter hydrocarbon fractions from the heavier fractions of hydrocarbon oil feedstocks is disclosed, which utilizes novel sparging and reverse distillation techniques. The present invention can be utilized for the facile “topping” of crude oil extracted on-site. Moreover, while heavier hydrocarbon fractions may be shipped to refineries for further processing, this invention will also prove useful for quick separation of light fractions produced by cracking processes off-site. | 2020-03-19 |
20200087585 | BORON AND/OR CARBON NANOFIBER MODIFIED ALUMINA-SUPPORTED MOLYBDENUM-COBALT CATALYSTS USEFUL IN HYDRODESULFURIZATION - Carbon nanofiber doped alumina (Al-CNF) supported MoCo catalysts in hydrodesulfurization (HDS), and/or boron doping, e.g., up to 5 wt % of total catalyst weight, can improve catalytic efficiency. Al-CNF-supported MoCo catalysts, (Al-CNF-MoCo), can reduce the sulfur concentration in fuel, esp. liquid fuel, to below the required limit in a 6 h reaction time. Thus, Al-CNF-MoCo has a higher catalytic activity than Al—MoCo, which may be explained by higher mesoporous surface area and better dispersion of MoCo metals on the AlCNF support relative to alumina support. The BET surface area of Al—MoCo may be 75% less than Al-CNF-MoCo, e.g., 166 vs. 200 m | 2020-03-19 |
20200087586 | THERMAL CRACKING OF CRUDE OIL USING A LIQUID CATALYST TO PREVENT COKE FORMATION AND PROMOTE ALKYLATION - A system and method for thermal cracking of crude oil is provided. The system includes a plurality of communicatively coupled components configured to support thermal cracking of crude oil and performs a method including a continuous, industrial-sized thermal cracking process used to convert heavy crude oil or extra-heavy crude oil into lighter crude oil, using a liquid catalyst to prevent coke formation and promote alkylation reactions. | 2020-03-19 |
20200087587 | PROCESS FOR CONVERTING C2-C5 HYDROCARBONS TO GASOLINE AND DIESEL FUEL BLENDSTOCKS - Disclosed is a process for converting C | 2020-03-19 |
20200087588 | PHOSPHORUS REMOVAL AND ALKYLATE PRODUCTION - Methods of reducing a phosphorus content of a liquid hydrocarbon. The liquid hydrocarbon may be co-fed with an olefin to an alkylation unit to produce a low-phosphorus content liquid hydrocarbon product. | 2020-03-19 |
20200087589 | PULVERIZED COAL GASIFICATION DEVICE AND PROCESS FOR PRODUCING HIGH HEATING VALUE COAL GAS WITH LOW CARBON RESIDUE CONTENT - A pulverized coal gasification device and process for producing high heating value coal gas with low carbon residue content includes a U-shaped coal gas generation furnace and a coal gas-semicoke separating device, and the U-shaped coal gas generation furnace consists of two section structures including high-temperature and low-temperature sections which are arranged in a U-shaped manner; the high-temperature section and the low-temperature section share an ash hopper; the high-temperature section is a downward entrained-flow bed, and the low-temperature section is an upward entrained-flow bed; and an inlet of the coal gas separating device is connected to the outlet of the low-temperature section, a solid outlet of the coal gas separating device is connected to an inlet of the high-temperature section, and a gas outlet of the coal gas separating device is connected to a coal gas waste heat utilizing and purifying system. The coal utilization rate can be greatly increased. | 2020-03-19 |
20200087590 | SYSTEM FOR, METHOD OF, AND THE RESULTING PRODUCT OF THE PRODUCTION OF FUEL GAS, HEAT AND ELECTRICITY AND THE CLEANING OF CARBON EMISSIONS - The field of present invention generally relates to furnaces that combine fuel production with both thermal and electrical energy production. They also are capable of using carbon emission as part of the production process. More particularly, the present invention produces a combustible gas that, within the internal workings of the present invention, can efficiently be burned at relatively lower temperatures and pressures without the production of high levels of pollutants. Further, the present invention can receive what are ordinarily wasteful carbon emissions for use in the production of more desirable outputs. The foregoing characteristics, along with the limited size of the elements needed to practice the present invention, make it conducive for use as and in connection with, among other things, residential furnaces and other heating systems, including, for example, heat exchangers and residential hot water tanks. In short, the present invention involves the production of a combustible fuel gas, and of thermal and electric energy, and the productive use of carbon emissions. This production is accomplished through the interconnected use of water electrolysis, catalysts, storage means, regulation, and mean of reusing materials to increase production efficiencies. | 2020-03-19 |
20200087591 | Systems and Methods for Generating and Consuming Power from Natural Gas - Systems and methods are provided to mitigate flaring of natural gas. A natural gas processing system may process raw natural gas into a fuel gas stream that may be used to power any number of on-site power generation modules. In turn, the power generation modules may convert the fuel gas stream into an electrical output, which may be employed to power any number of distributed computing units housed within one or more mobile data centers. In certain embodiments, the distributed computing units may be adapted to mine cryptocurrency or perform other distributed computing tasks to generate revenue. | 2020-03-19 |
20200087592 | LOW-FRICTION POLYMERIZABLE COMPOSITION - The present invention relates to a low friction polymerizable composition, a prepolymer thereof, and a friction component material prepared using the same, and the low friction polymerizable composition according to the present invention includes a curing agent and a filler together with a phthalonitrile compound, and thus has an excellent low friction property as well as high heat resistance and excellent processability. | 2020-03-19 |
20200087593 | Composition and Method of Manufacturing Calcium Magnesium Sulfonate Greases - A sulfonate-based grease composition and method of manufacture comprising (1) addition of both overbased calcium sulfonate and overbased magnesium sulfonate in a ratio range of 60:40 to 100:1, with the magnesium sulfonate added all at once, a portion prior to conversion and another portion after conversion, and/or one more delay periods between the addition of water or other reactive ingredient and the addition of magnesium sulfonate; (2) one or more delay periods between the addition of at least a portion of a facilitating acid and at least a portion of the next subsequently added ingredient; (3) no conventional non-aqueous converting agents added prior to conversion; or (4) a combination thereof. The grease has a high dropping point and reduced thickener yield. | 2020-03-19 |
20200087594 | LUBRICANT COMPOSITION AND LUBRICATING SYSTEM - The present invention provides a lubricant composition suitable for reducing friction between sliding members such as those within a pump for circulating a heat medium of a heat pump device, and a lubricating system using the composition as a heat medium. A lubricant composition | 2020-03-19 |
20200087595 | METHOD FOR PROCESSING USED OILS - The invention relates to a method for lowering the content of polycyclic aromatic hydrocarbons (PAH) in a used lubricant composition, in which said used lubricant composition passes over activated carbon, said method not comprising a solvent extraction step. | 2020-03-19 |
20200087596 | COMPOSITIONS FOR MALODOR REDUCTION AND USES THEREOF - Disclosed in certain embodiments are compositions for malodor reduction in fabric and methods for reducing malodor in fabric. | 2020-03-19 |
20200087597 | Encapsulated Solid Enzyme Product - A pouch comprising a wall forming a chamber, the wall comprising a water-soluble polymer, and the chamber containing a particulate solid comprising an enzyme, and a liquid comprising a surfactant and/or a polyol. A method of preparing a pouch and a method of preparing an enzyme-containing detergent composition are disclosed. | 2020-03-19 |
20200087598 | SOLID SCENT BOOSTER COMPOSITION - Described herein is solid scent booster composition including:
| 2020-03-19 |
20200087599 | CLEANING FLUID COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME - A cleaning fluid composition, a method of manufacture of the fluid composition, and a method of use thereof are provided. The fluid composition comprises 10% to 50% by weight of an alcohol based on the total weight of the fluid composition, 2% to 40% by weight of a co-solvent based on the total weight of the fluid composition, and at least 20% by weight of water based on the total weight of the fluid composition. The co-solvent is miscible with water, the fluid composition is substantially free of ethylene glycol and methanol, and the fluid composition has a viscosity less than or equal to 45 cP at −25 degrees Celsius and a freezing point less than −25 degrees Celsius. | 2020-03-19 |
20200087600 | DETERGENT COMPOSITIONS HAVING SURFACTANT SYSTEMS - Detergent compositions having surfactant systems that include alkyl ethoxylated sulfate surfactant (AES) and linear alkyl benzene sulfonate surfactant (LAS). Methods of treating fabric with such compositions. | 2020-03-19 |
20200087601 | METHOD OF MANAGING CONSUMPTION OF SOAP - A method for managing hard soap bar consumption is disclosed. In one embodiment, a first portion of the hard soap bar surface remains exposed to allow that portion of the soap bar surface to interface with the water as a traditional soap bar, and a second portion of the soap bar surface is configured to receive a hydro-phobic and oleo-phobic coated film that prevents the soap bar material below the film from interacting with the water. The oleo-phobic coating also prevents oil particles (and their associated germs) from attaching to the surface of the membrane. In this embodiment, only the first portion of the soap bar material is interfacing (being used) while the soap bar material below the second portion is not interfacing and thus remains hard and intact. As the soap bar material in the first portion is being used, the membrane along the planar outer perimeter edge is also gradually fading. | 2020-03-19 |
20200087602 | LIQUOR QUALITY OPTIMIZATION DEVICE - A liquor quality optimization device includes a main body defining a receiving chamber having an inlet portion and an outlet portion; an adaptor head coupled to the inlet portion of the main body for attachment to a liquor container, having a fluid passage in communication with the receiving chamber of the main body and an air passage in communication between the fluid passage and an exterior of the adaptor head; and a liquor molecular refinement structure disposed within the receiving chamber in the main body, having properties to cut and refine macromolecules in liquor into small molecules, thereby accelerating conversion of ingredients in the liquor which affects the taste, and decanting new brewed liquor as aged liquor in taste in addition to filtering sediments in liquor to enhance the taste of liquor. | 2020-03-19 |
20200087603 | BIOREACTOR MODULE, A BIOREACTOR SYSTEM AND METHODS FOR THICK TISSUE SEEDING AND CULTIVATION IN AN HIERARCHICAL ORGANIZATION AND PHYSIOLOGICAL MIMICKING CONDITIONS - According to various embodiments, there is provided a bioreactor module including a container; a holder removably receivable in the container, the holder adapted to hold a scaffold containing an inherent vascular network; an inlet connectable to a vessel of the inherent vascular network of the scaffold; an inflatable device disposed substantially near a base of the container, the inflatable device having a conduit extending through a wall of the container; and a pair of electrodes attached to opposing walls of the container. | 2020-03-19 |
20200087604 | LARGE SCALE CELL GROWING DEVICES AND SYSTEMS - A cell-growing system may include a cell-growing container, a pump for controlling the pressure of the chamber of the container, a filter for maintaining the chamber sterilized, a flow control regulator for controlling the substance supplied to the cell-growing container. The cell-growing container may include an internal structure that takes the form of a reticulated structure to increase the surface area for growing cells. The cell-growing system may be used to perform cycles of cell expansion and harvest. The cell-growing system may be maintained as a closed and sterilized system through the cycles. In harvesting, a first subset of the cells can be disassociated from the cell culture while a second subset remains. The disassociated cells may be discharged to a collection container while maintaining the system closed to an external environment. The remaining cells may be used as seeds to proliferate more cells in the next cycle. | 2020-03-19 |
20200087605 | BAG ASSEMBLY FOR CULTIVATION OF CELLS - The invention discloses a flexible bag assembly for cultivation of cells, comprising one or more bags forming a plurality of cultivation compartments, wherein a drain port in at least a first cultivation compartment is adapted to be fluidically connected with a second cultivation compartment upon opening of a valve means. It also discloses a bioreactor with the bag assembly mounted on a rocking tray and a method of cultivating cells in the assembly. | 2020-03-19 |
20200087606 | DEVICES AND METHODS FOR ISOLATING A MIGRATORY CELL POPULATION - A method and device, for isolating a migratory cell population from a mixed population of migratory cells and non-migratory cells is described herein. The method comprises placing the mixed population of migratory cells and non-migratory cells in contact with a device having one or more microchannels; and isolating the migratory cell population within the microchannels following an incubation period, wherein the one or more microchannels have an average size in a proliferation direction of the migratory cells that is less than a minimum proliferation space of the migratory cells along the proliferation direction. | 2020-03-19 |
20200087607 | CELL CULTURE CASSETTES AND INCUBATOR - The invention relates to cassettes for culturing cells. The invention also relates to analytical and preparative incubators for housing the cassettes. The invention also relates to methods of using the cassettes, for example, to culture cells wherein the processes of feeding and passaging cells are automated. | 2020-03-19 |
20200087608 | CELL CULTURE SYSTEM - The embodiments of the invention described herein relate to systems and methods for culturing and/or maintaining intestinal cells, tissues and/or organoids in vitro. The cells, tissues and/or organoids cultured according to the methods and systems described herein can mimic or reproduce natural intestinal epithelial structures and behavior as well as support co-culture of intestinal microflora. | 2020-03-19 |
20200087609 | REMOVAL OF MICROORGANISMS FROM CELL CULTURE MEDIA - Compositions and methods are provided for removing viral contaminants from a chemically defined cell culture medium. Compositions provided herein are resistant to or exhibit reduced fouling by one or more components in a chemically defined cell culture medium. | 2020-03-19 |
20200087610 | CULTURING APPARATUS AND CULTURING METHOD - A culturing apparatus ( | 2020-03-19 |
20200087611 | MICROORGANISM TESTING METHOD AND APPARATUS FOR THE SAME - A method and apparatus for detecting microorganisms in ballast water, the apparatus including: an excitation light source provided with light sources for emitting excitation light to irradiate an irradiated surface of sample solution continuously; photodetector detecting light of fluorescence emission caused by excitation light from the excitation light source control means converting the light detected by the photodetector to an electrical signal to detect and count number of light emissions, and estimating the number of microorganisms included in a sample within the sample container from the number of light emissions; and an operation unit electrically connected to the control means. The excitation light source uses two different kinds of excitation light sources including a light source emitting light with a wavelength region causing phytoplankton to emit chlorophyll fluorescence and a light source emitting light with a wavelength region causing microorganisms stained by the fluorescent staining reagent to emit fluorescence. | 2020-03-19 |
20200087612 | DEVICE FOR DERIVING ANTARCTIC CHIONODRACO RASTROSPINOSUS SKIN ANTIFREEZE PROTEIN - A device for manufacturing Antarctic chionodraco rastrospinosus skin antifreeze protein includes a de-frozen and cleaning device for de-frosting frozen grass carp skin and then cleaning carp skin; a skin slurry for making de-fat skin slurry; upper fat on the skin slurry being removed to get de-fat skin slurry; an ultrasonic generator for ultrasonic treatment to change organizational structure of skin antifreeze proteins of the slurry; a composite protease adder for adding composite protease added to the slurry; a collector receiving the slurry from the adder, and then the slurry are retained a time period and cooled to room temperature; then a 4000 g centrifugation is performed through 10 min; and a two-step filter connected to the collector for receiving the supernatant from the collector for performing a two-step ultra-filtration process so as to get skin antifreeze protein with molecular weight of 8000˜10000 Dalton and. | 2020-03-19 |
20200087613 | INSTRUMENTS, MODULES, AND METHODS FOR IMPROVED DETECTION OF EDITED SEQUENCES IN LIVE CELLS - The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited. | 2020-03-19 |
20200087614 | A Method and System for Separating Biomolecules - A separation system, a method in a separation system and an elution arrangement to be provided in a separation system for separating a biomolecule from a cell culture are provided. The method comprises the steps of: —providing a feed from a cell culture ( | 2020-03-19 |
20200087615 | SYSTEMS AND METHODS FOR MEDICAL DEVICE CONTROL - Systems, devices, and methods of the present disclosure assist with management of tubes and hoses during surgical procedures. The systems, devices, and methods provide for the proper opening and closing of tubes to facilitate performance of steps in a surgical procedure. Systems, devices, and methods of the present disclosure control fluid delivery to and from a medical device, including devices for tissue processing and cleaning. | 2020-03-19 |
20200087616 | CELL SUPPORTING SERUM - Failing and degenerating organs may be induced to recover by administering a serum augmenting natural paracrine to extend replenishment. The serum may be collected from a stressed culture of cells and administered to an organ and/or tissue. The stressed serum may also be combined with cells to be implanted to increase recovery, viability and/or establishment of cells. | 2020-03-19 |
20200087617 | 2D ORGANOID FOR INFECTION AND CULTURE OF HUMAN DIARRHEA VIRUS, AND USE OF SAID 2D ORGANOID - A 2D organoid for infection and growth culture of human diarrhea virus, obtained by: (1) obtaining a 3D organoid by three-dimensionally culturing a human intestinal epithelial stem cell, a human intestinal epithelial cell, or a tissue containing at least any of those cells on an extracellular matrix; and (2) dispersing the 3D organoid to prepare a single cell, and monolayer-culturing the single cell on an extracellular matrix to obtain the 2D organoid having a monolayer structure in which epithelial cells contain differentiated trophoblastic cells and goblet cells and configured as human intestinal lumen having a monolayer structure. | 2020-03-19 |
20200087618 | METHOD OF MANUFACTURING A CULTURE SUPPORT HAVING IMPROVED CELL ADHESIVENESS AND MOBILITY - Provided is a method of manufacturing a cell culture support having improved cell adhesion and mobility. The method includes: mixing a hydrophilic polymer, a hydrophobic polymer and a solvent to prepare an electro-spinning solution having a viscosity from 50 cps to 2000 cps; electro-spinning the electro-spinning solution to form polymer fibers having beads formed on each of the fibers; accumulating the polymer fibers to form a fibrous web having pores; and penetrating a culture solution into the pores of the fibrous web. The beads have a diameter larger than that of the polymer fibers. | 2020-03-19 |
20200087620 | METHODS OF MAINTAINING, EXPANDING, AND DIFFERENTIATING NEURONAL SUBTYPE SPECIFIC PROGENITORS - Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors. | 2020-03-19 |
20200087621 | Glycosaminoglycan Mimetic Scaffolds - Sodium cellulose sulfate (NaCS) is employed as a novel GAG mimetic. Schwann cells (SCs) could be used in combination with a scaffold because the SCs can secrete neurotrophic factors stimulating neuron survival and extension of axons. Furthermore, the conduit may be used alone or combination with Schwann cells for spinal cord repair. In addition, the conduit also can be used for peripheral nerve repair. Also described herein are compositions and methods useful for promoting the growth and/or differentiation and/or repair of a cell and/or tissue in the peripheral nervous system, central nervous system, and specifically the spinal cord. In certain aspects, the present disclosure includes a scaffold supporting and promoting growth, differentiation, and/or regeneration and repair. The scaffold in one embodiment closely mimics the natural extracellular matrix (ECM) of the spinal cord. | 2020-03-19 |
20200087622 | METHODS FOR DIFFERENTIATING PLURIPOTENT STEM CELLS IN DYNAMIC SUSPENSION CULTURE - Methods for differentiating pluripotent stem cells to neuroectoderm in dynamic suspension culture using small molecule or protein inhibitors of TGFβ/Activin/Nodal signaling and BMP signaling are provided. Also provided are methods and protocols for differentiating pluripotent stem cells such as human embryonic stem cells first to neuroectoderm, then further to glial progenitor cells, and further to oligodendrocyte progenitor cells (OPCs), and compositions obtained thereby. The methods of the present disclosure reproducibly produce neuroectoderm progenitor cells by day 7 of the differentiation process, glial progenitor cells by day 21 of the differentiation process and OPCs by day 42 of the differentiation process. | 2020-03-19 |
20200087623 | Generation of Human Spinal Cord Neural Stem Cells - Spinal cord neural stem cells (NSCs) have great potential to reconstitute damaged spinal neural circuitry. In some embodiments, derivation of spinal cord NSCs from human pluripotent stem cells (hPSCs) is described. These spinal cord NSCs can differentiate into a diverse population of spinal cord neurons comprising multiple positions in the dorso-ventral axis, and can be maintained for prolonged time periods. After grafting into injured spinal cords, grafts may be rich with excitatory neurons, extend large numbers of axons over long distances, innervate their target structures, and enable robust corticospinal regeneration. In some embodiments, hPSC-derived spinal cord NSCs enable a broad range of biomedical applications for in vitro disease modeling, and can provide a clinically-translatable cell source for spinal cord “replacement” strategies in several spinal cord disorders. | 2020-03-19 |
20200087624 | COMPOSITION COMPRISING B REGULATORY CELLS - The present invention relates to an expanded population of human Breg cells having the phenotype CD19+CD73−CD71+CD25+TIM-1+ and methods for producing the cell population of the invention. The invention also relates to pharmaceutical compositions comprising the cell populations of the invention and their use in the treatment of immune-mediated disorders. | 2020-03-19 |
20200087625 | METHODS FOR ISOLATING, EXPANDING AND ADMINISTERING CANCER SPECIFIC CD8+ T CELLS - Methods to isolate and expand tumor specific CD8+ T cells, and the use thereof, are provided. Also provided are method of using TLR7 agonists. | 2020-03-19 |
20200087626 | WNT-ACTIVATED ADIPOSE-DERIVED STEM CELL APPARATUSES, METHODS AND SYSTEMS - The WNT-ACTIVATED ADIPOSE-DERIVED STEM CELL APPARATUSES, METHODS AND SYSTEMS (hereinafter “WAADSC”) disclosed herein in various embodiments provide for production of an isolated and enriched population of mesenchymal stem cells that have an active Wnt signaling demonstrated by the elevated expression of Lrg5 marker and/or Nestin in more than 50% of the population. Such an autologous cell population may, in embodiments, be injected into cerebral ventricles of patients with neurodegenerative diseases to yield therapeutic results, such as halting the progression of certain conditions and/or ameliorating specific symptoms thereof | 2020-03-19 |
20200087627 | METHODS OF EXTRACTING HEMATOPOIETIC CELLS FROM BONE MARROW EX VIVO - The invention provides cellular compositions that contain CD34 | 2020-03-19 |
20200087628 | ADVANCED PULMONARY MODELS - The present invention relates to microfluidic fluidic systems and methods for the in vitro modeling diseases of the lung and small airway. In one embodiment, the invention relates to a system for testing responses of a microfluidic Small Airway-on-Chip infected with one or more infectious agents (e.g. respiratory viruses) as a model of respiratory disease exacerbation (e.g. asthma exacerbation). In one embodiment, this disease model on a microfluidic chip allows for a) the testing of anti-inflammatory and/or anti-viral compounds introduced into the system, as well as b) the monitoring of the participation, recruitment and/or movement of immune cells, including the transmigration of cells. In particular, this system provides, in one embodiment, an in-vitro platform for modeling severe asthma as “Severe Asthma-on-Chip.” In some embodiments, this invention provides a model of viral-induced asthma in humans for use in identifying potentially effective treatments. | 2020-03-19 |
20200087629 | COMPOSITIONS AND METHODS FOR REPROGRAMMING CELLS AND FOR SOMATIC CELL NUCLEAR TRANSFER USING DUXC EXPRESSION - It was found that DUXC family proteins were efficient activators of EGA and that DUXC proteins could be used in methods in the reprogramming of cells to a totipotent state and to increase the efficiency of somatic cell nuclear transfer (SCNT). Accordingly, aspects of the disclosure relate to a method for reprogramming a cell into a totipotent state, the method comprising expressing a DUXC family protein in the cell. Further aspects of the disclosure relate to a method for making a host cell nuclear transfer (SCNT) embryo comprising expressing a DUXC protein in a somatic cell and transferring the nucleus of the somatic cell to an enucleated oocyte, thereby making a SCNT embryo. | 2020-03-19 |
20200087630 | INFLUENZA VIRUS AND TYPE 1 DIABETES - Type 1 diabetes mellitus is characterized by loss of pancreatic insulin-producing beta cells, resulting in insulin deficiency. The usual cause of this beta cell loss is autoimmune destruction. The inventors provide the first evidence of a causal link between influenza virus infection and the development of type 1 diabetes and/or pancreatitis. This causal link between infection and type 1 diabetes and/or pancreatitis provides various therapeutic, prophylactic and diagnostic opportunities. | 2020-03-19 |
20200087631 | METHODS AND COMPOSITIONS RELATING TO VIRAL LATENCY - Disclosed are compositions and methods that relate generally to viruses, and more particularly to the agents and their identification and use of anti-HIV agents which cause latently infected cells to reactivate. | 2020-03-19 |
20200087632 | METHODS, APPARATUSES, AND SYSTEMS FOR CONTINUOUSLY INACTIVATING A VIRUS DURING MANUFACTURE OF A BIOLOGICAL PRODUCT - Methods for continuously inactivating virus during manufacture of a biological product are provided. The methods include steps of (1) combining (a) a composition including a biological product, and (b) a composition including a virus-inactivation reagent, to obtain (c) a treatment composition having a predetermined property for inactivation of a virus, (2) confirming that the treatment composition exhibits the predetermined property, (3) transferring the treatment composition to a treatment vessel that includes an inlet, an outlet, and a static mixer, the transferring occurring at the inlet, (4) incubating the treatment composition in the treatment vessel at a predetermined temperature while the treatment composition flows at a predetermined rate and contacts the static mixer, and (5) collecting the treatment composition from the treatment vessel at the outlet, wherein steps (1) to (5) are carried out continuously. Apparatuses and systems including such a treatment vessel are also provided. | 2020-03-19 |
20200087633 | GLUCOSE DEHYDROGENASE VARIANTS WITH IMPROVED PROPERTIES - The present invention relates to improved variants of variants of the Glucose Dehydrogenases (GlucDH) derived from | 2020-03-19 |
20200087634 | 3-HYDROXYBUTYRYL-COA DEHYDROGENASE VARIANTS AND METHODS OF USE - The present disclosure provides thiolases and polypeptide variants of 3-hydroxybutyryl-CoA dehydrogenase, nucleic acids encoding the same, vectors comprising the nucleic acids, and cells comprising the polypeptide variants and/or thiolase, the nucleic acids, and/or the vectors. The present disclosure also provides methods of making and using the same, including methods for culturing cells, and for the production of various products, including 3-hydroxybutyryl-CoA (3-HB-CoA), 3-hydroxybutyraldehyde (3-HBal), 3-hydroxybutyrate (3-HB), 1,3-butanediol (1,3-BDO), and esters and amides thereof, and products made from any of these. | 2020-03-19 |
20200087635 | HYPERACTIVE PIGGYBAC TRANSPOSASES - The present invention provides PiggyBac transposase proteins, nucleic acids encoding the same, compositions comprising the same, kits comprising the same, non-human transgenic animals comprising the same, and methods of using the same. | 2020-03-19 |
20200087636 | POLYMERASE VARIANTS AND USES THEREOF - Described herein is a variant pol6 polymerase having at least one mutation selected from H223, N224, Y225, H227, I295, Y342, T343, I357, S360, L361, I363, S365, S366, Y367, P368, D417, E475, Y476, F478, K518, H527, T529, M531, N535, G539, P542, N545, Q546, A547, L549, I550, N552, G553, F558, A596, G603, A610, V615, Y622, C623, D624, I628, Y629, R632, N635, M641, A643, I644, T647, I648, T651, I652, K655, W656, D657, V658, H660, F662, L690 and combinations thereof. | 2020-03-19 |
20200087637 | ENGINEERED POLYMERASES FOR IMPROVED SEQUENCING - Provided are nucleic acids encoding engineered polymerases comprising at least one modification in a motif A and/or at least one modification in a motif B of the polymerase and engineered polymerases encoded by the nucleic acids. Also provided are engineered DNA polymerases comprising a variant of SEQ ID NO:1, SEQ ID NO:2, or SEQ ID NO:3, the variant being at least 80% identical to SEQ ID NO:1, SEQ ID NO:2 or SEQ ID NO:3 and comprising an amino acid substitution at one or more positions selected from the group consisting of L408, Y409, P410, R484, A/L485, and I486. Methods, vectors, kits, and compositions comprising the nucleic acids and compositions, methods and kits comprising the engineered polymerases are also provided. | 2020-03-19 |
20200087638 | ENGINEERED POLYMERASES FOR IMPROVED SEQUENCING - Provided are nucleic acids encoding engineered polymerases comprising at least one modification in a motif A and/or at least one modification in a motif B of the polymerase and engineered polymerases encoded by the nucleic acids. Also provided are engineered DNA polymerases comprising a variant of SEQ ID NO:1, SEQ ID NO:2, or SEQ ID NO:3, the variant being at least 80% identical to SEQ ID NO:1, SEQ ID NO:2 or SEQ ID NO:3 and comprising an amino acid substitution at one or more positions selected from the group consisting of L408, Y409, P410, R484, A/L485, and I486. Methods, vectors, kits, and compositions comprising the nucleic acids and compositions, methods and kits comprising the engineered polymerases are also provided. | 2020-03-19 |
20200087639 | VARIANT CAS9 PROTEINS WITH IMPROVED DNA CLEAVAGE SELECTIVITY - Bridge helix-modified variant Cas9 proteins having improved DNA cleavage selectivity in comparison to wild type versions of the Cas9 proteins, nucleic acids encoding the variant proteins, host cells containing the nucleic acids, and methods of their use. | 2020-03-19 |
20200087640 | CASZ COMPOSITIONS AND METHODS OF USE - Provided are compositions and methods that include one or more of: (1) a “CasZ” protein (also referred to as a CasZ polypeptide), a nucleic acid encoding the CasZ protein, and/or a modified host cell comprising the CasZ protein (and/or a nucleic acid encoding the same); (2) a CasZ guide RNA that binds to and provides sequence specificity to the CasZ protein, a nucleic acid encoding the CasZ guide RNA, and/or a modified host cell comprising the CasZ guide RNA (and/or a nucleic acid encoding the same); and (3) a CasZ transactivating noncoding RNA (trancRNA) (referred to herein as a “CasZ trancRNA”), a nucleic acid encoding the CasZ trancRNA, and/or a modified host cell comprising the CasZ trancRNA (and/or a nucleic acid encoding the same). | 2020-03-19 |
20200087641 | CRISPR ENZYME MUTATIONS REDUCING OFF-TARGET EFFECTS - Disclosed and claimed are mutation(s) or modification(s) of the CRISPR enzyme, for example a Cas enzyme such as a Cas9, which obtain an improvement, for instance a reduction, as to off-target effects of a CRISPR-Cas or CRISPR-enzyme or CRISPR-Cas9 system or complex containing or including such a mutated or modified Cas or CRISPR enzyme or Cas9. Methods for making and using and uses of such mutated or modified Cas or CRISPR enzyme or Cas9 and systems or complexes containing the same and products from such methods and uses are also disclosed and claimed. | 2020-03-19 |
20200087642 | METHODS AND COMPOSITIONS FOR MODIFYING A SINGLE STRANDED TARGET NUCLEIC ACID - The present disclosure provides compositions and methods for binding and/or cleaving a single stranded target nucleic acid. Subject compositions include a Cas9 polypeptide, a guide nucleic acid, and a PAMmer. A subject PAMmer is a single stranded oligonucleotide having a proto spacer adjacent motif (PAM) sequence and at least one of: a specificity segment positioned 5′ of the PAM sequence, and an orientation segment positioned 3′ of the PAM sequence. In some embodiments, the Cas9 polypeptide is a variant Cas9 polypeptide having reduced nuclease activity relative to a corresponding wild type Cas9 polypeptide. In some cases, methods of binding are for visualizing single stranded target nucleic acids using a detectable label. In some cases, methods of binding are for isolating, collecting, and/or analyzing at least one of: (i) bound single stranded target nucleic acids; and (ii) polypeptides associated with bound single stranded target nucleic acids. | 2020-03-19 |
20200087643 | Enzymes for Glycan Analysis - The present invention relates to enzymes and combinations thereof useful for studying glycoproteins, and corresponding methods of use. In particular, the invention relates to a sialidase composition comprising an additional protease and/or glycosidase, preferably an O-glycoprotein-specific endoprotease and/or an O-glycosidase. | 2020-03-19 |
20200087644 | ALPHA-AMYLASE COMBINATORIAL VARIANTS - Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing. | 2020-03-19 |
20200087645 | Polypeptides Having Xylanase Activity And Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having xylanase activity, catalytic domains, carbohydrate binding modules and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding modules. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding modules. | 2020-03-19 |
20200087646 | OPTIMIZED HUMAN CLOTTING FACTOR IX GENE EXPRESSION CASSETTES AND THEIR USE - The invention relates to synthetic liver-specific promoters and expression constructs for producing polypeptides and functional nucleic acids in the liver of a subject. The invention further relates to optimized polynucleotide sequences encoding Factor IX proteins, vector comprising the same, and methods of using these compositions to treat a bleeding disorder. | 2020-03-19 |
20200087647 | A RECOMBINANT STRAIN HAVING MODIFIED SUGAR METABOLIC PATHWAY AND METHOD FOR SCREENING SUGAR ISOMERASE USING SAME - The present invention relates to a recombinant strain having a modified sugar metabolic pathway resulting from the introduction of an enzyme derived from a different strain to a strain, and a high-speed screening method for various mutants and variants by which useful materials can be obtained or which can produce useful materials. The use of a recombinant vector and a strain according to the present invention not only can construct a new metabolic pathway in a strain to effectively obtain D-tagatose from D-galactose, but also can introduce randomly modified sugar isomerases and then allow D-galactose isomerase variants to be rapidly screened by conducting a cell growth-associated screening system. | 2020-03-19 |
20200087648 | PARKIN LIGASE ACTIVATION METHODS AND COMPOSITIONS - The present invention is directed to methods and compositions for activating a Parkin ligase by administering to a subject in need thereof a therapeutically effective amount of a compound that disrupts at least one Parkin ligase zinc finger. The present invention is also directed to methods of treating and/or reducing the incidence of diseases or conditions related to the activation of Parkin ligase. | 2020-03-19 |
20200087649 | METHOD OF ATTACHING A CELL-OF-INTEREST TO A MICROTUBE - A method of attaching a cell or a membrane-coated particle-of-interest to a microtube is provided. The method comprising: co-electrospinning two polymeric solutions through co-axial capillaries, wherein a first polymeric solution of the two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of the two polymeric solutions is for forming a coat over an internal surface of the shell, the first polymeric solution is selected solidifying faster than the second polymeric solution and a solvent of the second polymeric solution is selected incapable of dissolving the first polymeric solution and wherein the second polymeric solution comprises the cell or the membrane-coated particle-of-interest, thereby attaching the cell or the membrane-coated particle-of-interest to the microtube. Also provided are microtubes with attached, entrapped or encapsulated cells or membrane-coated particles and methods of using same | 2020-03-19 |
20200087650 | METHODS OF ATTACHING A MOLECULE-OF-INTEREST TO A MICROTUBE - A method of attaching a molecule-of-interest to a microtube, by co-electrospinning two polymeric solutions through co-axial capillaries, wherein a first polymeric solution of the two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of the two polymeric solutions is for forming a coat over an internal surface of the shell, the first polymeric solution is selected solidifying faster than the second polymeric solution and a solvent of the second polymeric solution is selected incapable of dissolving the first polymeric solution and the second polymeric solution comprises the molecule-of-interest, thereby attaching the molecule-of-interest to the microtube. An electrospun microtube comprising an electrospun shell, an electrospun coat over an internal surface of the shell and a molecule-of-interest attached to the microtube. | 2020-03-19 |
20200087651 | TARGETING BCL11A DISTAL REGULATORY ELEMENTS FOR FETAL HEMOGLOBIN REINDUCTION - Provided herein are methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels. | 2020-03-19 |
20200087652 | CAPTURE OF NUCLEIC ACIDS USING A NUCLEIC ACID-GUIDED NUCLEASE-BASED SYSTEM - Provided herein are methods and compositions for the capture of nucleic acids, for example by using a nucleic acid-guided nuclease-based system. | 2020-03-19 |
20200087653 | CBLB ENDONUCLEASE VARIANTS, COMPOSITIONS, AND METHODS OF USE - The present disclosure provides improved genome editing compositions and methods for editing a CBLB gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of, a cancer, an infectious disease, an autoimmune disease, an inflammatory disease, or an immunodeficiency. | 2020-03-19 |
20200087654 | METHOD OF OBTAINING FETAL CELL NUCLEIC ACIDS - In the present invention, a fraction (A) is labeled, the fraction (A) being a fraction obtained from a maternal blood sample and in which nucleated red blood cells (NRBCs) are concentrated in a population of whole blood cells. Then, a fraction (B) having increase purity of NRBCs is obtained by sorting out blood cells in the labeled fraction A by at least cell sorting. Next, fractions (C) are obtained by separating each blood cell in the fraction (B) at a single-cell level and independently performing a process for extracting a nucleic acid for each separated blood cell, each of the fractions (C) containing a nucleic acid distinguishable at a single-cell level. Then, a fraction (D) containing a nucleic acid derived from a fetus is sorted out from a group of fractions (C) by performing a molecular biological analysis for each of the fractions (C). | 2020-03-19 |
20200087655 | PURIFICATION OF NUCLEIC ACIDS USING COPPER-TITANIUM OXIDES - The present disclosure relates to systems and methods for purifying nucleic acid. In particular, the present disclosure relates to systems and methods for purifying nucleic acids using metal or metal oxide compositions. | 2020-03-19 |
20200087656 | SAMPLE PREPARATION DEVICE AND METHODS OF USE - A device for isolating DNA from a sample containing cells, including a cartridge having an entrance port and an exit port, a membrane disposed between the entrance port and the exit port, and a plurality of channels between the membrane and the exit port. Additionally, systems and methods for isolating DNA from a sample containing cells and also systems and methods for amplifying and isolating single-stranded DNA from a sample containing DNA. | 2020-03-19 |
20200087657 | HIGH-THROUGHPUT IDENTIFICATON OF INTERMOLECULAR INTERACTIONS - Methods of detecting an interaction between a macromolecule and an interaction partner are described. Kits are also described. | 2020-03-19 |
20200087658 | EMULSION-BASED SCREENING METHODS - The present disclosure relates to compositions, systems and methods for analyzing activity of nucleases. | 2020-03-19 |
20200087659 | RNA ENGINEERED T CELLS FOR THE TREATMENT OF CANCER - The present invention relates to compositions and methods for generating RNA Chimeric Antigen Receptor (CAR) transfected T cells. The RNA-engineered T cells can be used in adoptive therapy to treat cancer. | 2020-03-19 |
20200087660 | TREATING AND PREVENTING MICROBIAL INFECTIONS - The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease. | 2020-03-19 |
20200087661 | COMPOSITIONS FOR MODULATING ATAXIN 2 EXPRESSION - Disclosed herein are antisense compounds and methods for decreasing Ataxin 2 mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate Ataxin 2 associated diseases, disorders, and conditions. Such Ataxin 2 associated diseases include spinocerebellar ataxia type 2 (SCA2), amyotropic sclerosis (ALS), and parkinsonism. | 2020-03-19 |
20200087662 | INHIBITION OF POLY(A) BINDING PROTEIN AND THE TREATMENT OF PAIN - The present disclosure describes chemically-stabilized RNA substrates that hybridize to poly-A binding protein (PABP) with high specificity in vitro, as well as their use in impairs nascent translation in a PABP-dependent mechanism in cells, thereby treating pain. | 2020-03-19 |
20200087663 | O-METHYL RICH FULLY STABILIZED OLIGONUCLEOTIDES - Novel oligonucleotides that are fully chemically stabilized are provided. Methods of using oligonucleotides that are fully chemically stabilized are also provided. | 2020-03-19 |