12th week of 2016 patent applcation highlights part 36 |
Patent application number | Title | Published |
20160084762 | Methods and Compositions for Highly Sensitive Detection of Molecules - Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution. | 2016-03-24 |
20160084763 | SYSTEM AND METHOD FOR EFFICIENT DETECTION OF THE PHASE AND AMPLITUDE OF A PERIODIC MODULATION ASSOCIATED WITH SELF-INTERFERING FLUORESCENCE - Systems and methods according to exemplary embodiments of the present disclosure can be provided that can efficiently detect the amplitude and phase of a spectral modulation. Such exemplary scheme can be combined with self-interference fluorescence to facilitate a highly sensitive depth localization of self-interfering radiation generated within a sample. The exemplary system and method can facilitate a scan-free depth sensitivity within the focal depth range for microscopy, endoscopy and nanoscopy. | 2016-03-24 |
20160084764 | SEPARATION OF DOPING DENSITY AND MINORITY CARRIER LIFETIME IN PHOTOLUMINESCENCE MEASUREMENTS ON SEMICONDUCTOR MATERIALS - Methods are presented for separating the effects of background doping density and effective minority carrier lifetime on photoluminescence (PL) generated from semiconductor materials. In one embodiment the background doping density is measured by another technique, enabling PL measurements to be analysed in terms of effective minority carrier lifetime. In another embodiment the effective lifetime is measured by another technique, enabling PL measurements to be analysed in terms of background doping density. In another embodiment, the effect of background doping density is removed by calculating intensity ratios of two PL measurements obtained in different spectral regions, or generated by different excitation wavelengths. The methods are particularly useful for bulk samples such as bricks or ingots of silicon, where information can be obtained over a much wider range of bulk lifetime values than is possible with thin, surface-limited samples such as silicon wafers. The methods may find application in solar cell manufacturing. | 2016-03-24 |
20160084765 | UBIQUITOUS TRANSMISSIVE RAMAN SPECTROSCOPY FOR STAND-OFF DETECTION - A substance analysis system and method are provided, the system disposable a variable stand-off distance from a substance in situ, including an emitter disposed to emit radiation onto the substance in situ, and a detector disposed the variable stand-off distance from the substance in situ, the detector comprising a receiver defining a substantially collimated collection path over the variable stand-off distance. | 2016-03-24 |
20160084766 | RAMAN SPECTROSCOPIC DETECTION DEVICE - A Raman spectroscopic detection device comprising at least one microfluidic sample channel; at least one excitation waveguide for exciting a Raman signal and at least one collection waveguide for collecting a Raman signal. The output of the excitation waveguide and the input of the collection waveguide are positioned directly in the microfluidic sample channel. | 2016-03-24 |
20160084767 | Compact, Low Cost Raman Monitor For Single Substances - Apparatus for performing Raman spectroscopy may include a first laser source having a first emission wavelength and a second laser source having a second emission wavelength. A separation between the first and second emission wavelengths may correspond to a width of a Raman band of a substance of interest. A switch may provide switching between the first and second laser sources. An ensemble of laser emitters may be provided. A Bragg grating element may receive laser light from the ensemble. An optical system may direct light from the Bragg grating element into an optical fiber. A combined beam through the optical fiber may contain light from each of the emitters. | 2016-03-24 |
20160084768 | DEVICE FOR DETECTING ANALYZED OBJECT IN SPECIMEN AND METHOD THEREFOR - A device for detecting analytes in a sample includes (a) n light source units generating light; (b) a reaction strip including (i) a test area illuminated with light from the light source unit and including a material reacting to the analytes, (ii) a control area illuminated with the light from the light source unit and including a control material, and (iii) a background area illuminated with the light from the light source unit; and (c) at least n+1 light receiving units detecting light emitted from the test area, the control area, and the background area of the reaction strip, respectively. | 2016-03-24 |
20160084769 | Fluorescent Caffeine Sensor And Portable Kit And Microfluidics Device For Caffeine Detection - The present invention relates to Caffeine Orange, a novel aqueous-phase fluorescence turn-on sensor for caffeine that is structurally based on a BODIPY-scaffold. The present invention further provides for methods of detecting and measuring caffeine in aqueous media. A change in the intensity or visible color of the fluorescence is detectable by either a fluorimeter or by the naked eye. The methods disclosed herein provide for the utilization of a reverse-phase SPE column, optionally as a component in a syringe or a microfluidics-based automation detection system. The invention further provides for the solid phase extraction of an analyte such as caffeine from a liquid medium, the extraction occurring on a microfluidic disc. | 2016-03-24 |
20160084770 | SYSTEM AND METHOD OF NEPHELOMETRIC DETERMINATION OF AN ANALYTE - A nephelometry system for an automatic analysis device may include a light source, a stop, and a photodetector on the one hand and a receptacle position on the other hand that are movable relative to one another in order to improve the measurement quality of a nephelometry system. The nephelometry system may determine a location of an interval I of recorded light intensity signals which only contains light intensity signals that emerge from a scattered portion of a light beam after passing through a measurement cell placed into the nephelometry system. Methods of nephelometric determination of an analyte are also provided, as are other aspects. | 2016-03-24 |
20160084771 | Sensor Unit, Electronic Module as well as Procedure to Calculate the Level of Corrosive Exposure of a Respective Electronic Module - The present invention refers to a sensor unit ( | 2016-03-24 |
20160084772 | DISPOSABLE AND DISPERSIBLE EXPLOSIVE DETECTION DEVICE AND METHOD OF SIMULTANEOUS DETECTION OF EXPLOSIVES - The present invention relates to a method and utility device for detecting explosives selected from inorganic nitrates like ammonium nitrate (AN), chlorates, nitramines like cyclo trimethylene trinitramine (RDX), Her Majesty's Explosive (HMX), tetryl (CE), nitrate esters like pentaerythritol tetranitrate (PETN), nitro compounds like trinitrotoluene (TNT) plastic explosives like Semtex, TATB and combinations thereof. It also relates to two variants of explosive detection kit viz. a readily portable miniaturized disposable drop type variant and a dispersible spray type variant. | 2016-03-24 |
20160084773 | METHOD AND SYSTEM FOR IMPROVING OPTICAL MEASUREMENTS ON SMALL TARGETS - A control system and method are provided for use in managing optical measurements on target structures. The control system comprises: data input utility for receiving input data indicative of a size of a target structure to be measured and input data indicative of illumination and collection channels of an optical measurement system; data processing utility for analyzing the input data, and an interplay of Point Spread Functions (PSFs) of the illumination and collection channels, and determining data indicative of optimal tailoring of apertures to be used in the optical measurement system for optimizing ensquared energy for measurements on the given target structure, the optimal tailoring comprising at least one of the following: an optimal ratio between numerical apertures of the illumination and collection channels; and an optimal orientation offset of physical apertures in the illumination and collection channels. | 2016-03-24 |
20160084774 | OPTICAL SENSOR - A lubricant deterioration sensor mounted in a machine to detect deterioration of a lubricant of the machine, the sensor comprising a white LED for emanating white light, an RGB sensor that detects colors of received light, a clearance forming member in which an oil clearance for intrusion of the lubricant is formed, and a support member that supports the white LED, the RGB sensor, and the clearance forming member; and wherein the clearance forming member allows passage of the light emitted from the white LED, and the oil clearance is placed along an optical path from the white LED to the RGB sensor. | 2016-03-24 |
20160084775 | LOW-ANGLE SELF-SWINGING, LARGE-SCALE MULTI-SLICE SPIRAL COMPUTED TOMOGRAPHY APPARATUS AND INSPECTION METHOD - The present disclosure provides a low-angle self-swinging type computed tomography (CT) apparatus, which is provided with an X-ray accelerator and a plurality of rows of detectors and is configured to include a slip ring, such that the slip ring with the accelerator and the detectors thereon is capable of performing a single-pendulum reciprocating movement while an objected to be inspected passes through the slip ring, a three dimension CT image of the object is displayed, thereby achieving accurate inspection for large-scale objects, such as van containers. | 2016-03-24 |
20160084776 | ALTERNATIVE FUELS ANALYZER - A process for preparing alternative fuels so that it is acceptable for use in cement plants and other manufacturing processes is detailed. This includes a material analyzer that can detect trace contaminants in alternative fuels. This new analyzer, combined with an associated method of processing the alternative fuels allows users to blend the fuel to ensure that it is acceptable for plant operations. | 2016-03-24 |
20160084777 | SPACER ACCESSORY FOR XRF HANDHELD ANALYZERS - Disclosed is an attachable spacer applied to the front base plate of a hand-held and self-contained XRF testing device that holds the face plate at a forwards tilt towards a test sample, and ensures that only the top rim of the face plate ever touches a test sample. The resulting triangular gap minimizes contact between the front plate window and the test surface, prevents the transfer of heat to the XRF testing device's circuitry, and locks in a fixed distance between the face plate of the XRF testing device and the sample being tested. | 2016-03-24 |
20160084778 | METHOD FOR EXANIMATION OF ELEMENT IN LIVING BODY - The nutritionally and/or medically significant measured value on mineral elements contained in the body of a test subject can be detected by a hair test. The signal ratio P | 2016-03-24 |
20160084779 | NUCLEAR MAGNETIC RESONANCE IMPLEMENTED SYNTHETIC INDOLE AND INDAZOLE CANNABINOID DETECTION, IDENTIFICATION, AND QUANTIFICATION - The present invention provides a method for detecting synthetic indole and indazole cannabinoids in a sample known or suspected to contain a synthetic indole or indazole cannabinoid. A deuterated solvent is added to the solid sample, creating a suspension. The suspension is mixed to release the cannabinoid from the solid sample. The suspension is subject to a NMR spectroscopy process to produce a sample NMR spectrum. The synthetic cannabinoid is detected in the suspension by analysis of the sample NMR spectrum. When one-dimensional proton NMR is used, detection of a first peak between 8.00 and 8.50 ppm and a second peak between 4.00 and 4.40 ppm, indicates the presence of a synthetic indole or indazole cannabinoid. When two-dimensional Correlation Spectroscopy (COSY) NMR is used, detection of a first spot between 6.50 and 9.00 ppm and a second spot between 1.50 and 4.50 ppm indicates the presence of a synthetic indole or indazole cannabinoid. The method is performed in the absence of chromatography and optionally, may be used to quantify the amount of synthetic cannabinoid. | 2016-03-24 |
20160084780 | LIQUID CONCENTRATION DETECTING DEVICE - A liquid concentration detecting device including a first substrate, a first temperature sensing element and a concentration sensor is provided. The first temperature sensing element and the concentration sensor are respectively disposed on opposite first surface and second surface of the first substrate. The concentration sensor includes a second substrate, a porous element, a heating element and a second temperature sensing element. The second substrate is disposed above the second surface. A portion of the liquid flows into the concentration sensor through the porous element, and the heating element heats the liquid in the concentration sensor. The second temperature sensing element measures the temperature variation of the liquid in the concentration sensor. The measured temperature and the temperature variation are compared to deduce a concentration of the liquid under detection. | 2016-03-24 |
20160084781 | APPARATUS AND METHOD FOR IDENTIFYING OBJECT - An element device and a method for identifying an object are provided. The method includes applying a current to a first coil from among a plurality of coils of the electronic device, measuring an induced current of a second coil among the plurality of coils, the second coil adjacent to the first coil, identifying information on an object which is located outside the electronic device based on the induced current, and performing a designated function based on a result of the identifying. | 2016-03-24 |
20160084782 | METHODS AND SYSTEMS OF DETECTING EXOCYTOSIS OF A TARGET MOLECULE FROM A POPULATION OF CELLS - Embodiments of various aspects described herein relate to methods and systems for detecting exocytosis or endocytosis of a target molecule from or into a population of cells, in part based on impedance analysis of the population of cells after they are exposed to an alternating current applied at two or more frequencies or to a repetitive voltage waveform. In some embodiments, the methods and systems described herein can be used for assessing viability and/or potency of the population of cells, and/or identifying a secretagogue for the target molecule released from the population of cells. | 2016-03-24 |
20160084783 | Method for Measuring Free Radical Based on Conductivity Change of Conductive Polymer - A method for measuring free radical comprises providing a sensor including a substrate and a conductive polymer layer, wherein the conductive polymer layer is configured on the substrate and made of conductive polymer; applying a liquid sample with free radical to the sensor so that the conductive polymer layer is covered with the liquid sample and the conductivity of the conductive polymer layer is lowered due to oxidation of the conductive polymer by free radical; and calculating the concentration of the free radical in the liquid sample based on the conductivity change rate of the conductive polymer before and after the liquid sample is applied to the conductive polymer. The present invention has advantages including low cost, small size, and ease of operation, which make it a good candidate for detecting hydroxyl radicals for oxidative stress studies. | 2016-03-24 |
20160084784 | Device For Measuring The Conductivity Of A Liquid In Order To Determine Very Low Levels Of Total Organic Carbon (TOC) In Pure And Ultra-Pure Water - The present patent application relates to a device ( | 2016-03-24 |
20160084785 | LIQUID CONDUCTIVITY MEASUREMENT CELL - The present invention provides a liquid conductivity measurement cell comprising a chamber having an inlet, an outlet and four sensing pins of substantially equal length, said sensing pins being arranged within the chamber around an orbit, each sensing pin defining an electrode, each of said electrodes being switchable between two or more configurations of two sensing pins. | 2016-03-24 |
20160084786 | GAS DETECTING DEVICE AND METHOD THEREOF - A gas detecting method includes heating a gas detector, formed of a gas sensing layer and an adsorption layer, for an oxygen adsorption period t | 2016-03-24 |
20160084787 | Micro Heater and Micro Sensor and Manufacturing Methods Thereof - A micro heater and a micro sensor is capable of providing a heater having a small thermal capacity by forming an air gap which surrounds the heater wire, and forming the heater wire on a porous substrate. | 2016-03-24 |
20160084788 | Molecularly Imprinted Polymer Sensors and Methods For Manufacturing The Same - A molecularly imprinted polymer sensor for sensing a target molecule includes (a) a polymer film that is molecularly imprinted with the target molecule and includes a conductive polymer having resistance sensitive to binding with the target molecule and a structural polymer providing porosity to the polymer film, and (b) interdigitated electrodes, located on a surface of the polymer film, for measuring a change in the resistance to sense said binding. | 2016-03-24 |
20160084789 | METHOD FOR INSPECTING COMPOSITE MATERIAL COMPONENTS - A method for inspecting a component constructed of a conductive composite material. The method includes the step of passing an alternating current signal through the component through an electrical interface. The impedance of the component from either a reflected or a through passage of the electric signal is then determined. That impedance is then compared with empirical data to determine the type and extent of damage or deterioration of the component. | 2016-03-24 |
20160084790 | Biosensor Desiccant System Having Enhanced Measurement Performance - A biosensor system for determining the concentration of an analyte in a sample includes a plurality of test sensors, and includes a container including a desiccant and the plurality of test sensors, sealed in the container. When the container is stored for two weeks at a temperature of 50° C., and each test sensor is subsequently removed from the container, connected through the at least two conductors to a measurement device and then contacted with one of a plurality of samples including an analyte, where the plurality of samples has analyte concentrations that span the range of 50 mg/dL-600 mg/dL, and the analyte concentration in each sample is determined by the test sensor and the measuring device, the bias of each determined analyte concentration may be within ±10 mg/dL or ±10%, and the coefficient of variation of the determined analyte concentrations may be at most 2.5%. | 2016-03-24 |
20160084791 | IDENTIFYING IONIZABLE SPECIES WITH VOLTAMMETRIC DUTY CYCLES - A sensor system including devices and methods for determining the concentration of an analyte in a sample is described. Input signals including amperometric and voltammetric duty cycles of excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed system may reduce analysis errors, thus improving measurement performance, by adjusting the potential and/or scan rate in response to output currents obtained from voltammetric scans. The disclosed system also may determine the concentration of more than one ionizable species in the sample by adjusting the potential and/or scan rate in response to output currents obtained from voltammetric scans. The multiple, determined concentrations may be used to determine the concentration of multiple analytes or to correct the concentration determined for an analyte, thus improving the measurement performance of the system. | 2016-03-24 |
20160084792 | ELECTROCHEMICAL TEST SENSOR - The present invention relates to electrochemical sensor strips and methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 μg/mm | 2016-03-24 |
20160084793 | ELECTRODE REACTION AREA TESTING METHOD OF BIOSENSOR TEST STRIP - An electrode reaction area testing method of biosensor test strip includes: (1) preparing a semi-finished or finished test strip product having at least one sensing window corresponding to an electrode reaction area; a plural electrodes exposed from the electrode reaction area; (2) detecting the electrode reaction current of the electrode reaction area to obtain a first electrode reaction current and a third electrode reaction current; (3) calculating a current ratio of the first electrode reaction current to the third electrode reaction current; (4) determining the current ratio; (5) completing the detection of the electrode reaction area to determine whether the semi-finished or finished test strip product is good or defective, so as to test the accuracy of the separating plate attaching position or the insulating position and the applicability of the electrode reaction area in the manufacture of the test strip. | 2016-03-24 |
20160084794 | Underfill Recognition Biosensor - A biosensor with an underfill recognition system assesses whether to analyze a sample for one or more analytes in response to the volume of the sample. The underfill recognition system applies polling and test excitation signals to the sample. The polling signals generate one or more polling output signals, which maybe used to detect when a sample is present and to determine whether the sample has sufficient volume for analysis. The test excitation signal generates one or more test output signals, which may be used to determine one or more analyte concentrations in the sample. | 2016-03-24 |
20160084795 | MEASUREMENT OF LACTIC ACID IN BIOLOGICAL FLUIDS - We propose a procedure for the determination of lactic acid or lactate in biological fluids, which is simple and low cost with respect to the known methodologies. This procedure can be used by unskilled personnel and it can be implemented in disposable test strips and portable measure devices. The procedure is based on the photochemical reaction of lactic acid with Fe(III), which is reduced to Fe(II) when irradiated with UV light. The Fe(II), produced proportionally to the amount of lactate in the sample, is determined electrochemically or using its reaction with a colored complexing agent, such as 1,10-phenanthroline, and determined by spectrophotometry. This method is advantageous both for the low cost of the reagents employed, and for their short and long term stability. | 2016-03-24 |
20160084796 | FLOW ASSAY WITH AT LEAST ONE ELECTRICALLY-ACTUATED FLUID FLOW CONTROL VALVE AND RELATED METHODS - Embodiments disclosed herein are directed to flow assays including at least one electrically-actuated valve configured to control fluid flow. Methods of operating such flow assays are also disclosed. | 2016-03-24 |
20160084797 | LEAK-PROOF GEL CASTING DEVICE FOR VERTICAL PROTEIN ELECTROPHORESIS SYSTEM - Disclosed is a leak-proof gel casting device for a vertical protein electrophoresis system which includes a gel caster which has a plurality of compartments and a sealing pad which is inserted to the compartments of the gel cater, and is formed to wrap around both sides and an edge of a lower side of a plate set. The present invention with a simple structure is capable of being manufactured at a low cost, does not require frequent replacement because of its long-term durability, and is highly effective in preventing the leakage of the gel placed in the gap between the plates. | 2016-03-24 |
20160084798 | ANALYSIS METHOD - An analysis method includes the steps of performing two-dimensional electrophoresis of analysis objects in an isoelectric direction and in a molecular weight direction that is substantially perpendicular to the isoelectric direction, cutting a medium containing the analysis objects, which have been subjected to the two-dimensional electrophoresis, in a lattice pattern along cut planes in the isoelectric direction and along cut planes in the molecular weight direction, and comparing the analysis objects between the cut mediums. | 2016-03-24 |
20160084799 | Apparatus and Methods for Ion Mobility Spectrometry - A method of ion mobility spectrometry wherein ions undergo multiple stages of ion mobility separation and multiple stages of inertial ion motion wherein the mean free path between ion collisions with gas is significantly longer than in the stages of ion mobility separation, wherein each stage of inertial ion motion lies between successive stages of ion mobility separation. | 2016-03-24 |
20160084800 | EDDY CURRENT INSPECTION PROBE BASED ON MAGNETORESISTIVE SENSORS - A device and method of eddy current based nondestructive testing of tubular structures made of electrically conductive materials is disclosed. The device includes a plurality of excitation electromagnets sensors having an easy axis for magnetic field sensing; wherein the magnetoresistive sensors are arranged in a circular array on a single plane with the easy axis aligned radially with respect to the circular pattern and wherein the electromagnets are arranged in a circular pattern on both sides of the plane with their axes of symmetry being arranged parallel to the plane and orthogonal to radii of the circular pattern on which the electromagnets are placed. | 2016-03-24 |
20160084801 | ACOUSTIC DETECTION IN PROCESS ENVIRONMENTS - An acoustic measurement system for an industrial process asset includes a process measurement device providing a value representative of an acoustic signal near the industrial process asset based in part on a signal from an acoustic sensor positioned near the industrial process asset. A second acoustic sensor provides an acoustic value and a noise reduction component uses the acoustic value from the second acoustic sensor to affect the value provided by the process measurement device so that the value provided by the process measurement device is more representative of an acoustic signal generated by the industrial process asset. | 2016-03-24 |
20160084802 | PROCESS FOR DETERMINING WELD QUALITY USING FLEXURAL CHARACTERISTICS - A process for determining the quality of a laser weld-seam, whereby a welded plate and a geometrically equivalent non-welded plate are subjected to a physical impact to generate a natural vibration frequency. The natural vibration frequency of the welded plate and the non-welded plate is then measured with an accelerometer and compared. The uniformity of the weld is then determined by the similarity between the natural vibration frequency of the welded plate and the geometrically equivalent non-welded plate. | 2016-03-24 |
20160084803 | DETECTION SYSTEM AND DETECTION METHOD - According to an embodiment, a detection system includes a plurality of sensor nodes and a sensor module. The plurality of sensor nodes detects sound waves generated from a prestressed concrete and converts the detected sound waves into detection signals. The sensor module is connected to the plurality of sensor nodes and receives the detection signals. The plurality of sensor nodes includes the sensor nodes in an operating state and the sensor nodes in a dormant state in which power consumption is held down as compared to the operating state. When magnitude of the detection signals is equal to or greater than a first threshold value, the sensor module switches the sensor node in the dormant state to the operating state. | 2016-03-24 |
20160084804 | CATION EXCHANGER FOR LIQUID CHROMATOGRAPHY, PROCESS FOR PRODUCING SAME, AND USE THEREOF - To provide a cation exchanger for liquid chromatography having a high retention for an object to be separated or analyzed, a sufficient binding capacity for the object, a high resolution and mechanical strength, and a low operation pressure. | 2016-03-24 |
20160084805 | SYSTEM AND METHOD OF PRECONCENTRATING ANALYTES IN A MICROFLUIDIC DEVICE - A method and system for preconcentrating analytes at a microvalve in a microfluidic device is disclosed. The system includes a sample channel loaded with a sample solution. The sample channel includes a semi-permeable membrane microvalve. An electric potential is applied at or across the microvalve to preconcentrate the sample solution when the microvalve is closed. The method includes pretreatments of the device or valve for preconcentration of the analytes. For preconcentration of anionic analytes, the device is baked. For preconcentration of the cationic analytes, the surface of the membrane microvalve is coated with a polycationic coating, and the device is baked. | 2016-03-24 |
20160084806 | Micro-Machined Frit and Flow Distribution Devices for Liquid Chromatography - A micro-machined frit is provided for use in a chromatography column, having a substrate with a thickness, and holes extending through the thickness and providing fluid communication through the substrate. A micro-machined flow distributor is provided for use in a chromatography column having a substrate, holes extending through the substrate, and channels in fluid communication with the holes. A micro-machined integrated frit and flow distributor device is also provided having a substrate with a thickness, holes extending through the thickness and providing fluid communication therethrough, and channels in fluid communication with at least one of the holes. A chromatography column is provided having a tube, an extraction medium contained therein, and a micro-machined frit positioned proximate an end of the tube. The column can include a micro-machined flow distributor positioned between the frit and the end of the tube. | 2016-03-24 |
20160084807 | AUTOMATED METHOD OF CALIBRATING A CHROMATOGRAPHY SYSTEM AND ANALYSIS OF A SAMPLE - An automated method of calibrating a chromatography system and analyzing a sample is described. The method includes forming diluted standard solutions that are injected into a chromatography column. The detected peaks can be identified based on a first predetermined calibration ratio associated with the standard solution. Once the chromatography system is calibrated, samples can be chromatographically analyzed where the measured peaks are identified and quantified in an automated manner. | 2016-03-24 |
20160084808 | METHOD AND DEVICE FOR DETERMINING A COMPOSITION OF A GAS SAMPLE PROCESSED BY MEANS OF GAS CHROMATOGRAPHY - A method for determining a composition of a gas sample comprising the following steps: running the sample through a processing chain comprising a gas chromatography column and a gas detector arranged at the outlet of the gas chromatography column; obtaining, at the output of the detector, a representative electrical signal of the composition; determining the gas composition by processing this electrical signal. The determination of the composition of the sample is performed on the basis of a combination of a direct probabilistic model of the chromatography column, this model comprising at least one law of probability defining, for at least one gas species liable to be found in the sample, a probability at each moment that a molecule of this gas species is discharged from the chromatography column, and an impulse response model of the detector. It is performed by inverting this combination of models using the electrical signal. | 2016-03-24 |
20160084809 | SIMULTANEOUS DETERMINATION OF MULTIPLE ANALYTES IN INDUSTRIAL WATER SYSTEM - A multi-purpose reagent composition is used for simultaneously determining concentrations of at least two analytes in a water sample. The two analytes are selected from the group consisting of free chlorine, pH, anionic polymer, and phosphates. In one embodiment, the multi-purpose reagent composition is for simultaneously determining the concentration of free chlorine and pH and comprises a free chlorine sensitive dye and pH indicator. In another embodiment, the reagent composition is for simultaneously determining of free chlorine and anionic polymer and includes a free chlorine sensitive dye, a pH buffer, cationic dye, and organic co- solvent. Thus, the pairs of free chlorine and pH or free chlorine and anionic polymer are determined using a single reagent composition. The reagent composition can also be the main reagent for one analyte analysis when it is used alone and also function as an ancillary reagent when it is combined with a second reagent composition for the determination of another analyte. | 2016-03-24 |
20160084810 | SYSTEMS FOR DETECTING TARGET CHEMICALS AND METHODS FOR THEIR PREPARATION AND USE - Systems and methods for detecting target chemicals are disclosed. A system includes a chemical sensor configured to filter light. The chemical sensor includes a referencing arm configured to output light at a first intensity level and a sensing arm sensitive to a target chemical. The sensing arm is configured to output light at a second intensity level. A difference between the first intensity level and the second intensity level indicates a presence of the target chemical. | 2016-03-24 |
20160084811 | A DUAL GAS SENSOR STRUCTURE AND MEASUREMENT METHOD - The invention relates to a sensor structure and a method. The sensor structure includes a first sensor having a sensing element sensitive to humidity of the environment. In_accordance with the invention the sensor structure also includes s second sensor having a sensing element sensitive to humidity, the second sensor comprising a catalytic permeable layer positioned on the second sensor such that it is between the sensing element of the second sensor and the environment. | 2016-03-24 |
20160084812 | CONTROL APPARATUS - A control apparatus that controls a gas concentration sensor includes a sweep circuit, a current detection resistor, and a calculation portion. The sweep circuit supplies the gas concentration sensor with a sweep current. The calculation portion calculates impedance of the gas concentration sensor. The gas concentration sensor and the current detection resistor are sequentially connected in series along a direction from the sweep circuit to a reference voltage. The sweep circuit has a constant voltage circuit and a reference resistor. An increasing and decreasing tendency of a manufacturing variation of the reference resistor and an increasing and decreasing tendency of a manufacturing variation of the current detection resistor are identical. The calculation portion divides a product of a resistance value of the current detection resistor and a time variation of applied voltage to the gas concentration sensor by a time variation of applied voltage to the current detection resistor. | 2016-03-24 |
20160084813 | YIELD ESTIMATION - A method and apparatus estimate yield. A first signal is received that indicates an aggregate yield measured by an aggregate yield sensor during a measurement interval. A second signal is received that indicates a plurality of geo-referenced regions across which a harvester has traveled prior to the measurement interval. The method and apparatus allocate, to each of at least two geo-referenced regions, an aggregate yield portion allocation based upon different travel times for crops to the aggregate yield sensor and pre-harvest weighting data value differences amongst the at least two georeferenced regions. The aggregate yield portion allocations are output. | 2016-03-24 |
20160084814 | SUBMERSIBLE FLOW IMAGER - Submersible technology capable of sampling and evaluating suspended particulate materials, including living and dead organisms, is disclosed herein. In addition to fluorescent imaging and analysis, the invention provides automated cell staining, cell sorting, particulate concentration, and organism recovery and preservation. These new technologies may be incorporated into a traditional “fully vertical flow path” cytometer configuration most suitable for anchored or suspended stationary embodiments, or in a novel modularized “low relief” configuration, suitable for integration into or on a submersible aquatic vehicle or in other low clearance installations, where it is important to limit the vertical height of the device. | 2016-03-24 |
20160084815 | METHODS AND SYSTEMS FOR QUANTIFYING THE GRADE OF PETROLEUM OIL BASED ON FLUORESCENCE - Systems and methods evaluate the grade or API gravity of petroleum. The methods and systems disclosed herein overcome many of the difficulties commonly associated with petroleum exploration. The methods and systems include collecting fluorescence emission spectra of soil samples and inputting these into an artificial neural network, which is able to rapidly and accurately assess and classify data from multiple soil samples. Additionally, the methods and systems can be useful in identifying other compounds related to or commonly found together with petroleum, including hydrocarbons and aromatic compounds. | 2016-03-24 |
20160084816 | METHOD FOR EVALUATING WEATHERING DEGREE OF COAL, METHOD FOR EVALUATING COKING PROPERTY OF WEATHERED COAL, METHOD FOR CONTROLLING WEATHERING DEGREE OF COAL, AND METHOD FOR PRODUCING COKE (AS AMENDED) - Provided are, by using an index with which the influence on the strength of coke can be evaluated, a method for evaluating a weathering degree of coal and a coking property of weathered coal within the ranges in which the weathering degree and coking property cannot be determined by using conventional methods, and a method for controlling the weathering degree of coal with which it is possible to add weathered coal to a coal blend to be used for producing coke without decreasing the strength of coke by using the index. The weathering degree of coal is evaluated by using the surface tension of semicoke which is prepared by performing a heat treatment on weathered coal as an index. The weathering degree of each brand of coal is controlled so that the interfacial tension γ | 2016-03-24 |
20160084817 | Method to Enhance Exploration, Development and Production of Hydrocarbons Using Multiply Substituted Isotopologue Geochemistry, Basin Modeling and Molecular Kinetics - A method and system are described that may be used for exploration, production and development of hydrocarbons. The method and system may include analyzing a sample for a geochemical signature, wherein the geochemical signature includes a multiply substituted isotopologue signature and/or a position specific isotope signature. Then, the historical temperature, type of alteration and/or extent of alteration may be determined from the signature(s) and used to develop or refine an exploration, development or production strategy. | 2016-03-24 |
20160084818 | METHOD FOR DEMONSTRATING THE NON-DRIP PROPERTIES OF A HAIR DYE - A method for demonstrating the non-drip properties of a hair dye composition comprising the following steps in this order: i. application of a hair dye to a stencil, the stencil being placed over a smooth horizontal substrate; ii. tilting the smooth substrate to an angle elevation from 20 to 60 degrees in relation to a horizontal plane; iii. removal of the stencil from the smooth substrate; iv. visualization of movement of the hair dye composition on the substrate. | 2016-03-24 |
20160084819 | METHOD AND ARRANGEMENT FOR DETECTING FREE FIBRE ENDS IN PAPER - The invention relates to a method and arrangement for detecting free fibre ends in a paper surface. The method comprises illuminating a target sample ( | 2016-03-24 |
20160084820 | METHODS OF TREATING OR PREVENTING PERIODONTITIS AND DISEASES ASSOCIATED WITH PERIODONTITIS - The present disclosure describes methods for preventing or treating periodontitis or diseases associated with periodontitis. The present disclosure also describes methods of screening for compounds that can be used to prevent or treat periodontitis or diseases associated with periodontitis. | 2016-03-24 |
20160084821 | METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF CANCER SUSCEPTIBILITIES AND DEFECTIVE DNA REPAIR MECHANISMS AND TREATMENT THEREOF - Methods and compositions for the diagnosis of cancer susceptibilities, defective DNA repair mechanisms and treatments thereof are provided. Among sequences provided here, the FANCD2 gene has been identified, and probes and primers are provided for screening patients in genetic-based tests and for diagnosing Fanconi Anemia and cancer. The FANCD2 gene can be targeted in vivo for preparing experimental mouse models for use in screening new therapeutic agents for treating conditions involving defective DNA repair. The FANCD2 polypeptide has been sequenced and has been shown to exist in two isoforms identified as FANCD2-S and the monoubiquinated FANCD-L form. Antibodies including polyclonal and monoclonal antibodies have been prepared that distinguish the two isoforms and have been used in diagnostic tests to determine whether a subject has an intact Fanconi Anemia/BRCA pathway. | 2016-03-24 |
20160084822 | USE OF BIOMARKERS FOR EVALUATING THE EFFECTIVENESS OF ACTIVE INGREDIENTS - The invention relates to a method for evaluating the effectiveness of an active ingredient selected from C7 avocado sugars, also called avocado perseose, for preventing or treating a deficiency of the skin barrier, said method comprising the determination of the level of expression and/or activation of at least one biological marker, where said biological marker is selected from epidermal maturation markers, lipid barrier markers, hydric regulation markers and | 2016-03-24 |
20160084823 | METHODS AND KITS FOR TESTING THE GENOTOXICITY OF AN AGENT - The present invention relates to methods and kits for testing the genotoxicity of an agent. In particular, the present invention provides a global assay for the measurement of genotoxic stress based on p53 target gene induction. In particular, the present invention relates to a method for testing the genotoxicity of an agent comprising the steps consisting of i) providing a population of test cells, ii) exposing the populations of test cells with the agent to be tested, iii) determining the expression level of at least one p53 target gene selected from the group consisting of ATF3, BBC3, CABYR, C10ORF10; EMX1; FHL2, GLS2; GRHL3; HES2; IGF-BP4; KIAA0284; PODXL1; RRAD; TP53I3, and XPC in the population of test cells exposed to the agent to be tested iv) comparing the expression level determined at step iii) with the expression level determined when the population of test cells was not exposed to the agent to be tested, and v) concluding that the agent is genotoxic when the expression level determined at step iii) is higher than the level determined when the population of test cells was not exposed to the agent to be tested. | 2016-03-24 |
20160084824 | DRUG DISCOVERY METHODS INVOLVING A PRECLNICAL, IN VITRO ISOLATED GASTROINTESTINAL EPITHELIAL STEM CELL-LIKE PROGENITOR CELL SYSTEM - The described invention relate to systems comprising isolated human gastrointestinal segment-specific epithelial stem cell-like progenitor cells and uses thereof in drug discovery. | 2016-03-24 |
20160084825 | STABILIZED LOW AFFINITY CONFORMATION OF INTEGRINS FOR DRUG DISCOVERY - The methods and compositions described herein are based, in part, on the discovery that the introduction of a disulfide bond into an integrin polypeptide by the substitution of at least one cysteine residue in the polypeptide permits stabilization of the integrin in a “closed/inactive” state. This stabilizing disulfide bond permits integrins to be screened for a candidate molecule that can bind to the closed state. In particular, this approach can be used to screen for agents that bind to the closed state of an integrin polypeptide, and are useful as therapeutic treatments to prevent integrin activation. | 2016-03-24 |
20160084826 | METHODS FOR TREATING ADHD AND BIPOLAR DISORDER USING A MEMBRANE POTENTIAL RATIO TEST - The present invention relates to a method for optimizing drug therapy treatment of patients with Attention Deficit Hyperactivity Disorder (ADHD) or Bipolar Disorder (BD), a method of optimizing drug dosage for treatment of ADHD and BD, a method of treating ADHD and BD, and a kit. The present method may also be used to adjust medication doses for individual patients. | 2016-03-24 |
20160084827 | AUTOMATED ANALYZER - Stepped portions of a flow channel are reduced by completely fixing the channel that extends to the measuring unit, and reducing connections in the channel, thereby to suppress a disturbance in the flow of the liquid suctioned into the measuring unit. A means is provided so that the reaction solution and reagent suctioned will move towards the channel through which the liquids are suctioned. | 2016-03-24 |
20160084828 | AUTOMATABLE METHOD FOR THE IDENTIFICATION, QUANTIFICATION AND DISCRIMINATION OF SPECIFIC SIGNALS IN RELATION TO NON-SPECIFIC SIGNALS IN DETECTION METHODS BY MEANS OF A DETECTOR - The invention relates to an automatable method for the identification, quantification and discrimination of specific signals in relation to non-specific signals in detection methods by means of a detector emitting or generating signals, in which at least one control approach is carried out in parallel to the actual test approach, which contains all the components of the actual test approach but in which the binding domain(s) of the detector is/are blocked. The analytical measurements of the signals of the control approach and of the actual test approach are compared with each other and the signal of the specifically bound detector in the test approach is calculated therefrom. | 2016-03-24 |
20160084829 | SELF-ASSEMBLED PEPTIDE NANOSTRUCTURES BY EXPLOITING CONFORMATIONAL CHANGE, BIOSENSOR USING THE SAME AND DETECTION METHOD OF BIOMOLECULES USING THE SAME - The present disclosure relates to a self-assembled peptide nanostructure including at least one amphiphilic peptide and a biosensor using the same. The amphiphilic peptide is a hairpin-shaped amphiphilic peptide including a hydrophilic domain having an α-helical structure and a hydrophobic domain. The N-terminal of the hydrophobic domain is a pyrene group. Since the self-assembled peptide nanostructure is derived from an RNA, DNA or amino acid sequence capable of recognizing a specific target substance, it does not recognize other substances but exhibits high selectivity for the target substance. Specifically, since the self-assembled peptide nanostructure has an excimer fluorescence peak at 480 nm through binding with the target substance, it can be usefully used in medical applications such as diagnosis of diseases. | 2016-03-24 |
20160084830 | SURFACE PLASMON RESONANCE BASED SENSING DEVICES AND METHODS FOR REAL-TIME ANALYSIS OF ANALYTE SECRETION FROM LIVING CELLS - The present invention provides surface plasmon resonance (SPR) based sensing systems and methods for rapid, sensitive, and real-time analysis of analyte secretion from living cells. In one embodiment, the SPR based sensing device of the present invention comprises at least one cell culture module for culturing living cells, wherein the cell culture module is configured so that analytes secreted from the living cells can be released onto a SPR sensing surface. | 2016-03-24 |
20160084831 | FLOW THROUGH TESTING SYSTEM WITH PRESSURE INDICATOR - A device for performing immunoassays on analytes is provided. The device includes an immunosorbent membrane, an absorbent material, a piston component located below said absorbent material to draw analytes in a sample through the immunosorbent membrane into the absorbent material, and discrete groups of pressure-sensitive microcapsules located on the immunosorbent membrane. | 2016-03-24 |
20160084832 | Method and Device for Combined Detection of Viral and Bacterial Infections - A lateral flow assay is capable of detecting and differentiating viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for bacterial infection, to effectively assist in the rapid differentiation of viral and bacterial infections. In some preferred embodiments, bimodal methods and devices determine if an infection is bacterial and/or viral. A dual use two strip sample analysis device includes a first lateral flow chromatographic test strip to detect MxA and a low level of C-reactive protein and a second lateral flow chromatographic test strip to detect high levels of C-reactive protein. In some preferred embodiments, the sample is a fingerstick blood sample. | 2016-03-24 |
20160084833 | DETECTING COMPLEMENT ACTIVATION - Methods of detecting complement activation including steps of detecting in a sample from a subject a level of iC3b wherein the detecting involves specific interaction between the iC3b and a non-cross-reactive antibody thereto, comparing the detected level with a reference level, which reference level is within a range of about 10 ng/ml to about 5,000 ng/ml, wherein determination that the detected level is above the reference level indicates that the subject is suffering from or susceptible to undesirable and/or pathologic complement activation, and administering treatment to treat undesired complement activation if the detected level is above the reference level. Other methods of detecting complement activation with or without measuring iC3b are also provided. | 2016-03-24 |
20160084834 | TASTE RECEPTOR INTERNALIZATION ASSAY - This disclosure provides a taste receptor internalization assay useful for identifying taste modulators. | 2016-03-24 |
20160084835 | METHODS FOR DIAGNOSING INFECTIOUS DISEASES USING ADSORPTION MEDIA - The present invention provides an in vitro method for concentrating infectious pathogens found in a biological sample obtained from an individual who is suspected of being infected with the pathogens. Provided herein is also an in vitro method for reducing or eliminating blood cells from a sample obtained from an individual suspected to being infected with an infectious pathogen. The present invention also provides a method for diagnosing malaria and a method for determining if an individual is infected with a pathogen. Provided herein is also a concentrator and a kit for use with the methods. | 2016-03-24 |
20160084836 | IMMUNOREACTIVE PROTEIN ORTHOLOGS OF EHRLICHIA CANIS AND E. CHAFFEENSIS - The present invention concerns gp36 immunoreactive compositions for | 2016-03-24 |
20160084837 | MONOCLONAL ANTIBODIES WITH SPECIFICITY FOR FETAL ERYTHROID CELLS - The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The inventive monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell. | 2016-03-24 |
20160084838 | Modulators of Itch Ubiquitinase Activity - The present invention relates to the identification of new drug targets for therapy of disorders including cancer. In particular, the present invention relates to inhibition of the E3 ubiquitin ligase, Itch, as a means for treating disorders. Furthermore, the present invention relates to the regulation of p63 and p73 stability in cells. In particular, the invention relates to the modulation of the regulation of p63 and p73 stability in cells through modulation of the expression or activity of Itch. Moreover, the invention relates to the use of Itch as a target for the development of agents capable of modulating p63 or p73 stability and especially agents capable of modulating the interaction of Itch and p63 and p73. Such agents may be useful in therapeutic applications including cancer treatment and modulation of skin differentiation. | 2016-03-24 |
20160084839 | IMMUNOHISTOCHEMICAL ASSAY FOR DETECTING EXPRESSION OF PROGRAMMED DEATH LIGAND 1 (PD-L1) IN TUMOR TISSUE - The present disclosure provides processes for describing and quantifying the expression of human programmed death ligand-1 (PD-L1) in tumor tissue sections as detected by immunohistochemical assay using an antibody that specifically binds to PD-L1. The results generated using these processes have a variety of experimental, diagnostic and prognostic applications. | 2016-03-24 |
20160084840 | IDENTIFICATION OF PROTEIN ASSOCIATED WITH HEPATOCELLULAR CARCINOMA, GLIOBASTOMA AND LUNG CANCER - The present invention provides methods and compositions for screening, diagnosis and prognosis of HCC, glioblastoma and lung cancer, for monitoring the effectiveness of HCC, glioblastoma and lung cancer treatment, and for drug development. | 2016-03-24 |
20160084841 | Method for Predicting Clinical Effect of Immunotherapy - Provided is a method for predicting a clinical effect on a subject in a WT1 peptide immunotherapy, said method comprising: a) a step for contacting a sample derived from the subject with WT1 antigen peptide or a variant thereof; and b) a step for detecting the binding of the sample to the WT1 antigen peptide or a variant thereof and thus measuring anti-WT1 antigen peptide IgG antibody titer existing in the sample, characterized in that an increase in the anti-WT1 antigen peptide IgG antibody titer in the subject determines the achievement of a favorable clinical effect. Also provided is a kit for performing the method according to the present invention, said kit containing WT1 antigen peptide or a variant thereof. | 2016-03-24 |
20160084842 | WOVEN HYDROGEL BASED BIOSENSOR - A porous hydrogel sensor that is responsive to the presence of one or more target compounds in solution is synthesized based on demixing of certain molecules in the presence of a target compound. The porous hydrogel sensor may include fluorescently tagged antibodies that are noncovalently bound to the gel and then released in the presence of the target antigen. The porous hydrogel sensor may alternatively include dissolvable cross-links using polymerized antibody and antigen complexes so that, in the presence of the target antigen, the cross-links will be displaced and the hydrogel will dissolve. | 2016-03-24 |
20160084843 | IN VITRO METHOD FOR THE EARLY DETECTION OF A POTENTIAL INFLAMMATION, IN PARTICULAR ASSOCIATED WITH REJECTION OF A TRANSPLANT, A NEURODEGENERATIVE DISORDER OR A DEPRESSION - An in vitro method for the early detection of a potential inflammation, in particular a rejection of a transplant is disclosed, wherein the level of kynurenine in saliva is determined. The test method can be easily performed and allows the early detection of potential problems. | 2016-03-24 |
20160084844 | METHODS OF IDENTIFYING GLYCOPEPTIDES RECOGNIZED BY DISEASE-ASSOCIATED AUTO-ANTIBODIES - Methods for identifying glycopeptides and more particularly glycopeptide epitopes that are specifically recognized by disease-associated auto-antibodies are provided. In some aspects the auto-antibodies are cancer-associated or autoimmune disease associated. In other aspects, methods of diagnosing a patient with cancer or an autoimmune disease, or for eliciting an immune response in a mammalian host directed to the glycopeptides of the invention are provided. | 2016-03-24 |
20160084845 | COMPOSITIONS AND METHODS FOR DETECTING S-NITROSYLATION AND S-SULFINYLATION - The present invention relates to methods for detecting protein S-sulfinylation and S-sulfinylation within thiol groups in proteins, metabolites, or materials. | 2016-03-24 |
20160084846 | METHODS AND COMPOSITIONS FOR DETERMINING RELAPSE IN INFLAMMATORY BOWEL DISEASE - Described are methods and compositions for evaluating the relapse risk n subjects having an inflammatory bowel disease (IBD). Some embodiments include selecting a treatment for an evaluated IBD relapse risk in a subject. | 2016-03-24 |
20160084847 | STABILIZED LIQUID FORMULATIONS CONTAINING RECEPTORS - Methods and reagents are disclosed for preparing a liquid solution of a receptor. The methods comprise combining in a liquid medium the receptor, a chelating agent and a C2-C6 polyol. An amount of the chelating agent and the C2-C6 polyol is sufficient to achieve a stable and active receptor in the liquid solution, which is maintained at a temperature of about 2° C. to about 40° C. The compositions may be employed in assays for the determination of analytes that include receptor-binding analytes. | 2016-03-24 |
20160084848 | ASSAY FOR DETERMINING ENDOGENOUS LEVELS OF ANALYTE IN VIVO - The present invention relates to an assay for determining endogenous levels of analyte in vivo. In particular, the present invention is directed to an assay for determining endogenous levels of stromal cell-derived factor (SDF-1) isoforms in vivo. | 2016-03-24 |
20160084849 | BIOMARKER COMPOSITE TEST FOR HEPATIC VEIN PRESSURE GRADIENT AND CIRRHOSIS TREATMENT - Diagnostic biomarker panel, method, kit, and device for diagnosing the severity and/or prognosis of cirrhosis are provided. More specifically, the invention provides a novel biomarker panel correlating to HVPG and esophageal varices. The invention further provides a biomarker panel and non-invasive test methods that predict non-clinically significant portal hypertension HVPG and non-clinically significant esophageal varices when the expression of the biomarker panel correlates with HVPG of less than 12 mmHg. The invention further provides that the patients with the expression of the biomarker panel correlating to non-clinically significant HVPG and esophageal varices can be excluded from undergoing esophagogastroduodenoscopy (EGD) screening and those correlating to HVPG equal to or greater than 12 mmHg are indicated for EGD. | 2016-03-24 |
20160084850 | METHOD FOR QUANTIFYING GLYCATED HEMOGLOBIN - A method for quantifying glycated hemoglobin (HbA1c) contained in a sample, the method including: (a) a process for mixing the sample with a protease in the presence of a composition of a cationic surfactant and a tetrazolium salt to obtain an aqueous glycated peptide solution containing a glycated peptide; (b) a process for mixing the aqueous glycated peptide solution obtained in process (a) with a fructosyl peptide oxidase to obtain hydrogen peroxide, the aqueous glycated peptide solution here containing the composition; and (c) a process for calculating the concentration of the glycated hemoglobin (HbA1c) on the basis of the amount of hydrogen peroxide solution obtained in process (b). | 2016-03-24 |
20160084851 | NOVEL BIOMARKERS - The invention relates to biomarkers for predicting whether a patient infected with Hepatitis B virus (HBV) will respond to interferon (IFN) therapy. The invention also relates to methods and kits for predicting whether a patient will respond to IFN therapy using said biomarkers. | 2016-03-24 |
20160084852 | METHODS OF DETERMINATION OF ACTIVATION OR INACTIVATION OF ATRIAL NATRIURETIC PEPTIDE (ANP) AND BRAIN NATRIURETIC PEPTIDE (BNP) HORMONAL SYSTEMS - An in vivo method of determining activation or inactivation of the atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) hormonal systems, the method comprising simultaneously detecting the presence or amount of atrial and brain natriuretic peptide prohormones (proANP and proBNP) or fragments thereof in a sample. | 2016-03-24 |
20160084853 | BIOMARKERS FOR AGE-RELATED MACULAR DEGENERATION (AMD) - The present application is directed to the use of a VEGF-C inhibitor, a VEGFR-2 inhibitor and/or a VEGFR-3 inhibitor as a prophylactic or therapeutic for the treatment of eye disorders such as a maculopathy and pathogenic ocular neovascularisation. The application is also directed to the use of a VEGF-C measurement from a biological sample from a mammalian subject as a predictive marker, a selected marker, a responsive marker or a tracking marker for a disease or condition selected from the group consisting of a maculopathy and pathogenic ocular neovascularization. | 2016-03-24 |
20160084854 | PROCESS CONTROL FOR INCREASED ROBUSTNESS OF GENETIC ASSAYS - The present disclosure describes a method of processing a biological sample. The method includes contacting the sample with a pH indicator that changes color in response to changes in pH. The presence of a pH indicator such as cresol red provides the benefit of improved visualization of the sample, verification that the sample is properly frozen and thawed, and increased precision in pH adjustments during the assay, among other benefits. | 2016-03-24 |
20160084855 | Compositions and Methods for Modulation and Detection of Immune and Inflammatory Responses - Methods for detecting inflammatory or autoimmune conditions, comprising analyzing bacterial L-serine containing lipids in a sample; and, comparing results of the analysis of the bacterial L-serine containing lipids in the sample with information on occurrence of the bacterial L-serine containing lipids in a control sample, wherein a decreased occurrence of the bacterial L-serine containing lipids in the test sample over the occurrence of bacterial L-serine containing lipids in the control sample indicates the presence of an inflammatory or an autoimmune condition, are described herein. An example of the autoimmune condition is multiple sclerosis (MS). The use of bacterial L-serine containing lipids as biomarkers for detection of MS is described. Antibodies specific to L-serine containing lipids and their uses are also provided. Also provided are compositions comprising bacterial L-serine containing lipids for modulating immune responses or TLR pathways in humans, animals, and human or animal cells or tissues. | 2016-03-24 |
20160084856 | HDL-ASSOCIATED PROTEIN EXTRACTION AND DETECTION - Provided herein are compositions, systems, and methods for extracting and detecting at least one HDL-associated protein (e.g., ApoA1) from a sample (e.g., plasma or serum sample). In certain embodiments, a strong organic acid and hydrophilic organic solvent are mixed with the sample; after centrifugation, the supernatant is transferred to a second container where it is mixed with a non-polar organic solvent; after centrifugation, the lower aqueous layer is transferred to a third container; and then at least a portion of the transferred aqueous layer is subjected to a detection assay such that at least one HDL-associated protein is detected. | 2016-03-24 |
20160084857 | FATTY ACID PATTERN ANALYSIS FOR PREDICTING ACUTE CORONARY SYNDROME - The present invention provides blood based methods for predicting risk of acute coronary syndrome in a subject. | 2016-03-24 |
20160084858 | SYSTEMS AND METHODS FOR NON-FASTING LDL CHOLESTEROL ASSAYS - In one embodiment, a test strip for testing for cholesterol-related blood analytes in whole blood includes a red blood cell separation layer, the red blood cell separation layer separating red blood cells from a blood sample applied to the test strip as the blood sample flows downward through the red blood cell separation layer. The test strip further includes a reaction layer receiving the blood sample from the red blood cell separation layer, the reaction layer including POE-POP-POE block copolymer, a surfactant, and a reflectivity changing reactant, the POE-POP-POE block copolymers solubilizing essentially only non-LDL cholesterol analytes, the non-LDL cholesterol analytes reacting with the reflectivity changing reactant in order to change a reflectivity of the blood sample. | 2016-03-24 |
20160084859 | DETECTION OF INDAZOLE SYNTHETIC CANNABINOIDS - Components for enabling immunodection of indazole synthetic cannabinoids are described including immunogens, haptens, antibodies, methods and kits. | 2016-03-24 |
20160084860 | MULTIFUNCTIONAL PROTEIN MOLECULAR WEIGHT LADDERS - Multifunctional molecular weight protein ladders and methods of making thereof are disclosed herein that are useful for determining the molecular weight of a test protein and/or the relative mass or amount of the test protein in a protein separation assay, such as gel electrophoresis or western blotting. Also included are compounds of Formula I (e.g., mono acetylated MP-11 NHS ester) that may be used to label purified proteins of the protein ladder. The MP-11 label protein ladder can be detected on a blotting membrane by exposing the microperoxidase to a suitable substrate, such as a chromogenic substrate or a chemiluminescent substrate. | 2016-03-24 |
20160084861 | CALIBRATION FOR MULTI-COMPONENT ASSAYS - A method of analyzing a biological sample using an analyzer and an assay. The method comprises providing the assay for producing the signal. The assay has two or more predetermined number of components. Each of the predetermined components has a distinct relation between the intensive property and the signal. The method further comprises providing calibration samples with known values for the intensive property and measuring a calibration signal for each of the calibration samples. The method further comprises determining a calibration by fitting a calibration function to the calibration signal for each of the calibration samples and the known values for the intensive property. The calibration function is equivalent to a constant plus an exponential decay term for each of the predetermined number of components. The method further comprises measuring the signal of the sample using the analyzer and the assay, and calculating the intensive property using the calibration. | 2016-03-24 |