13th week of 2015 patent applcation highlights part 51 |
Patent application number | Title | Published |
20150087512 | ANTIMICROBIAL COMPOUNDS AND THEIR USE IN TREATING PLANT DISEASE - The subject invention is directed toward antimicrobial agents and methods of treating and preventing infection by pathogenic microorganisms and endophytic microorganisms in a plant through the use of SecA inhibitors. | 2015-03-26 |
20150087513 | HERBICIDAL COMPOUNDS - The present invention relates to compounds of Formula (I), or an agronomically acceptable salt of said compounds wherein A | 2015-03-26 |
20150087514 | METHODS OF WEED CONTROL IN CHICORY - Disclosed herein are methods of controlling undesirable vegetation in chicory which can comprise applying to vegetation or an area adjacent the vegetation or applying to soil to prevent the emergence or growth of vegetation (a) penoxsulam or an agriculturally acceptable salt thereof. The methods can further comprise applying (b) a second pesticide or an agriculturally acceptable salt or ester thereof to the vegetation or the area adjacent the vegetation, or to the soil adjacent thereto. In some embodiments, (b) includes an ALS inhibitor (e.g., triflusulfuron-methyl), an inhibitor of microtubule assembly (e.g., propyzamide, trifluralin, or benfluralin), a cellulose biosynthesis inhibitor (e.g., isoxaben), a protoporphyrinogen oxidase (PPO) inhibitor (e.g., flumioxazin), or combinations thereof. | 2015-03-26 |
20150087515 | HERBICIDAL COMPOSITION - To provide a high active herbicidal composition having a broad herbicidal spectrum. | 2015-03-26 |
20150087516 | ENHANCED FORMULATIONS, COMPOSITIONS AND METHODS FOR PEST CONTROL - Formulations of pesticides are disclosed, specifically pesticidal blends of essential oils and other ingredients, that have been found to enhance the activity of the active pesticidal ingredients. The formulations may be, for example, emulsions or dust formulations. For example, a composition for controlling a target pest is disclosed that comprises at least one active agent and a formulation agent, wherein: the active agent is capable of interacting with a receptor in the target pest; the active agent has a first activity against the target pest when applied without the formulation agent and the composition has a second activity against the target pest; and the second activity is greater than the first activity. | 2015-03-26 |
20150087517 | MANUFACTURING OF SPECIFICALLY TARGETING MICROCAPSULES - The present disclosure relates to the manufacturing of specifically targeting microcapsules comprising agrochemicals. More specifically, the disclosure relates to specifically targeting microcapsules, to which targeting agents are covalently linked at a ratio from about 0.01 μg-to about 1 μg targeting agents per square centimeter of the surface of the microcapsule, such that the microcapsules are capable of binding the agrochemicals contained in the microcapsules to a surface, and to agrochemical compositions comprising such microcapsules. | 2015-03-26 |
20150087518 | CONTROL OF AAD DICOT VOLUNTEERS IN MONOCOT CROPS - The subject invention relates in part to the control of AAD-12 and/or AAD-13 dicot volunteers in fields planted with monocot crops such as corn. The dicots can include soybeans and cotton. | 2015-03-26 |
20150087519 | Substituted N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamide compounds and their use as herbicides - N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides of formula I and their use as herbicides, | 2015-03-26 |
20150087520 | SYSTEMS AND METHODS FOR SOVLENT-FREE DELIVERY OF VOLATILE COMPOUNDS - Provided are systems and methods for solvent-free delivery of volatile compounds, where an energy source is used to release the volatile compounds. The systems and methods provided herein have at least one advantage of (1) no solvent (for example water) is required; (2) immediate release of volatile compounds (for example 1-MCP can be released from HAIP within milliseconds or seconds instead of minutes or hours of the existing method using water); and/or (3) instantly starting and stopping the delivery of the volatile compound. | 2015-03-26 |
20150087521 | UNSATURATED FATTY ALCOHOL DERIVATIVES FROM NATURAL OIL METATHESIS - Sulfate and sulfonate derivatives of unsaturated fatty alcohols, processes for making them, and methods of using them are disclosed. In one aspect, a monounsaturated fatty alcohol composition is made by reducing a metathesis-derived monounsaturated alkyl ester. The fatty alcohol composition is then converted to a sulfate or sulfonate derivative by one or more of alkoxylation, sulfation, sulfonation, and sulfitation. Of particular interest are the sulfate and ether sulfate derivatives. | 2015-03-26 |
20150087522 | SUPERCONDUCTING ANTENNA DEVICE - A superconducting antenna device of an embodiment includes an array antenna made by stacking a flat antenna having one or more antennas made of a superconducting material and a ground pattern on a low-loss dielectric substrate from a short wave band to an extremely-high frequency band, a vacuum chamber configured to accommodate the array antenna, a refrigerator configured to cool the array antenna, and a vacuum insulating window configured to pass an electromagnetic wave from a short wave band to an extremely-high frequency band in a direction of directivity of the array antenna in the vacuum chamber. | 2015-03-26 |
20150087523 | SUPERCONDUCTIVE ELECTRIC MOTOR AND GENERATOR - A non-traditional topology of a superconductive electric motor or generator increases the air gap flux density by reducing stray flux and concentrating lines of flux within the air gap. An electric motor or generator utilizing the invention will include three components: a rotating armature, a permanent magnet stator and a shielding sleeve. The shielding sleeve of the motor is a hollow cylinder that fits between the armature and the stator, and is configured to cool a plurality of high-temperature superconductors within it to a temperature below their critical temperatures. These superconductors are placed at an optimized position to redirect flux and promote greater efficiency. | 2015-03-26 |
20150087524 | METHOD FOR PRODUCING SUBSTRATES FOR SUPERCONDUCTING LAYERS - There is provided a method for producing a substrate ( | 2015-03-26 |
20150087525 | PLASMA MICRORNAS FOR THE DETECTION OF EARLY COLORECTAL CANCER - The present invention relates in general to the field of colorectal cancer detection, and more particularly, to plasma microRNAs for the detection of early colorectal cancer. Specifically, the present invention includes methods, kits and biomarkers for diagnosing or detecting colorectal neoplasia in a human subject comprising the steps of: A method for diagnosing or detecting colorectal neoplasia in a human subject comprising the steps of: obtaining one or more biological samples from the subject suspected of suffering from colorectal neoplasia; measuring an overall expression pattern or level of one or more microRNAs obtained from the one or more biological samples of the subject; and comparing the overall expression pattern of the one or more microRNAs from the biological sample of the subject suspected of suffering from colorectal neoplasia with the overall expression pattern of the one or more microRNAs from a biological sample of a normal subject, wherein the normal subject is a healthy subject not suffering from colorectal neoplasia, wherein overexpression of a combination of miR19a and miR19b, or miR19a and miR19b and miR15b is indicative of colorectal cancer. | 2015-03-26 |
20150087526 | PEPTIDE IDENTIFICATION AND SEQUENCING BY SINGLE-MOLECULE DETECTION OF PEPTIDES UNDERGOING DEGRADATION - The present disclosure provides peptide amino acid sequencing and identification methods and kits for performing such methods. For example, single-molecule detection of fluorophore-labeled peptides is disclosed using multiple rounds of standard Edman degradation or using digestion by chemicals or enzymes. Different fluorophores covalently attached to each of a specific type of amino acid side chain of a peptide provide for the derivation of the peptide's encoded amino acid sequence following image alignments of multiple Edman cycles or following digestion by chemicals or enzymes. The amino acid sequence of a peptide and/or the identity of the peptide can be determined by bioinformatic analysis based on the encoded amino acid sequence. The present disclosure further provides peptide derivatization and immobilization strategies to enable the sequencing and identification of a single peptide or a plurality of peptides. | 2015-03-26 |
20150087527 | METHOD AND KIT FOR THE CLASSIFICATION AND PROGNOSIS OF TISSUE OR ORGAN FIBROSIS IN A REPARATIVE OR REACTIVE PROCESS - The invention relates to methods of diagnosis or prognosis of a tissue or organ fibrosis (e.g., skin fibrosis, hypertrophic scar or a keloid) in a reparative or reactive process comprising the step of determining the levels of expression of genes encoding different molecular markers in a sample of a tissue or organ from a mammalian, wherein different genes markers are studied. | 2015-03-26 |
20150087528 | DNA AMPLIFICATION AND SEQUENCING USING DNA MOLECULES GENERATED BY RANDOM FRAGMENTATION - The present invention is directed to methods to prepare a DNA molecule or a plurality of DNA molecules by random fragmentation. In some embodiments, the present invention regards preparing a template for DNA sequencing by random fragmentation. In specific embodiments, the random fragmentation comprises chemical fragmentation, mechanical fragmentation, or enzymatic fragmentation. In further specific embodiments, a universal sequence is attached to the 3′ end of the DNA fragments, such as by ligation of an adaptor sequence or by homopolymeric tailing with terminal deoxynucleotidyltransferase. In other embodiments, a library is prepared with methods of the present invention. | 2015-03-26 |
20150087529 | SEQUENCING ANALYSIS OF CIRCULATING DNA TO DETECT AND MONITOR AUTOIMMUNE DISEASES - Systems, methods, and apparatuses are provided for diagnosing auto-immune diseases such as systemic lupus erythematosus (SLE) based on the sizes, methylation levels, and/or genomic characteristics of circulating DNA molecules. Patients provide blood or other tissue samples containing cell-free nucleic molecules for analysis. Massively parallel and/or methylation-aware sequencing can be used to determine the sizes and methylation levels of individual DNA molecules and identify the number of molecules originating from different genomic regions. A level of SLE can be estimated based on: the amount of molecules having sizes below a threshold value; the methylation level(s) of the entire genome or portions of the genome; correlations between the sizes and methylation levels of DNA molecules; and/or comparing the representation of DNA molecules in each of a plurality of genomic regions with a reference value for that region, and determining an amount of genomic regions having increased or decreased measured genomic representation. | 2015-03-26 |
20150087530 | Low-Volume Sequencing System and Method of Use - Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than about 100 μl). The system can also include an automated reagent delivery mechanism configured to reversibly couple with the inlet port corresponding to a target reaction chamber thereby placing allowing for reagent to be accurately moved from a storage container to the reaction chamber with minimal reagent waste. The flowcells can include a plurality of reaction chambers (e.g., 6) thereby allowing for parallel analysis of multiple samples. Various methods of analyzing a biomolecule are also provided herein. | 2015-03-26 |
20150087531 | METHOD OF NUCLEIC ACID AMPLIFICATION - A nucleic acid molecule can be annealed to an appropriate immobilized primer. The primer can then be extended and the molecule and the primer can be separated from one another. The extended primer can then be annealed to another immobilized primer and the other primer can be extended. Both extended primers can then be separated from one another and can be used to provide further extended primers. The process can be repeated to provide amplified, immobilized nucleic acid molecules. These can be used for many different purposes, including sequencing, screening, diagnosis, in situ nucleic acid synthesis, monitoring gene expression, nucleic acid fingerprinting, etc. | 2015-03-26 |
20150087532 | AFFINITY REAGENTS FOR PROTEIN PURIFICATION - Disclosed herein are methods and compositions for purifying proteins from crude solutions. | 2015-03-26 |
20150087533 | LIGAND SCREENING AND DISCOVERY - Disclosed is a method that includes: (i) providing a plurality of initial nucleic acid cassettes that include: a) a first coding region encoding a first immunoglobulin variable domain, b) a second coding region encoding a second immunoglobulin variable domain, and c) a ribosomal binding site disposed between the first and second coding regions for translation of the second polypeptide in a first expression system, wherein the first and second coding regions are in the same translational orientation; (ii) modifying each nucleic acid cassette of the plurality in a single reaction mixture so that it is functional in a second expression system, wherein the first and second region remain physically attached during the modifying; (iii) introducing each modified nucleic acid cassette into a mammalian cell to produce a mixture of transfected cells; and (iv) expressing each modified nucleic acid cassette in the transfected cells. | 2015-03-26 |
20150087534 | METHODS OF NUCLEIC ACID SEQUENCING - Provided herein is a method of using transposition to improve methods of sequencing RNA molecules. Provided herein is a method of tagging nucleic acid duplexes, such as DNA:RNA duplexes or DNA:DNA duplexes. The method includes the steps of providing a transposase and a transposon composition, providing one or more nucleic acid duplexes immobilized on a support, and contacting the transposase and transposon composition with the one or more nucleic acid duplexes under conditions wherein the one or more nucleic acid duplexes and transposon composition undergo a transposition reaction to produce one or more tagged nucleic acid duplexes, wherein the transposon composition comprises a double stranded nucleic acid molecule comprising a transferred strand and a non-transferred strand. | 2015-03-26 |
20150087535 | MEASUREMENT OF NUCLEIC ACID VARIANTS USING HIGHLY-MULTIPLEXED ERROR-SUPPRESSED DEEP SEQUENCING - Methods and compositions are disclosed for measuring low-abundance DNA variants from a complex mixture of DNA molecules. Embodiments of the methods allow for extremely sensitive detection and can distinguish true variants from sequencer misreads and PCR misincorporations. | 2015-03-26 |
20150087536 | USE OF APTAMERS IN PROTEOMICS - The present invention is a method for measuring the amount of at least one molecule in a biological sample, the method comprising a) combining the sample, or a derivative thereof, with one or more aptamers and allowing one or more molecules in the sample to bind to the aptamer(s); b) separating bound from unbound molecules; and c) quantifying the molecule(s) bound to the or each aptamer, wherein quantification of the bound molecule(s) is carried out by sequencing at least part of the or each aptamer. Uses of and products derived from the method are also contemplated. | 2015-03-26 |
20150087537 | Methods, Systems, Computer Readable Media, and Kits for Sample Identification - A method for sequencing a polynucleotide sample having a barcode sequence includes: introducing a series of nucleotides to the polynucleotide sample according to a predetermined order of nucleotide flows; obtaining a series of signals resulting from the introducing of nucleotides to the polynucleotide sample; and resolving the series of signals over the barcode sequence to render a flowspace string, wherein the flowspace string is a codeword of an error-correcting code that is (i) designed based on and adapted for use with the predetermined order of nucleotide flows, and (ii) capable of distinguishing any codeword in the error-correcting code from the other codewords in the error-correcting code in the presence of zero, one, and two errors. | 2015-03-26 |
20150087538 | Cancer Blood Test Using BC200 RNA Isolated from Peripheral Blood for Diagnosis and Treatment of Invasive Breast Cancer - Compositions and methods for diagnosing an increased risk for the development of aggressive, invasive breast cancer are provided. | 2015-03-26 |
20150087539 | METHOD FOR PREDICTING OUTCOME OF CANCER IN A SUBJECT - The invention relates to a method for predicting the outcome of a subject suffering from cancer, based on the copy number of the CHKA gene in a sample from said subject. The invention also relates to a BAC composition and a method for detecting the number of copies of the CHKA gene. | 2015-03-26 |
20150087540 | Composition for Diagnosing Sepsis, and Method and Kit Therefor - A composition for diagnosing sepsis, and a method and a kit therefor. The kit includes a primer composition containing specific individual primers for amplifying: a segment of a 16s rRNA gene; a segment of an ITS gene; a segment of a Nuc gene; a segment of a MecA gene; segments of a VanA and a VanB; a segment of an invA gene; a segment of an ipaH gene; and a segment of a Cps gene. The kit also includes a probe composition containing specific individual probes for detecting: gram-negative bacteria; gram-positive bacteria; a Nuc gene; a MecA gene for checking whether or not MRSA has antibiotic resistance; a VanA and a VanB, for checking whether or not VRE have antibiotic resistance; and a gene for identifying a fungus. | 2015-03-26 |
20150087541 | Derivation of Neural Stem Cells and Dopaminergic Neurons from Human Pluripotent Stem Cells - The present invention is based in part on a chemically defined method of generating neural stem cells (NSCs) and dopaminergic (DA) neurons from human pluripotent stem cells (hPSCs). The DA neurons of the invention can be derived from hPSCs and NSCs. The present invention also provides reagents and kits useful for the derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells. | 2015-03-26 |
20150087542 | SCREENING METHOD FOR THE DETECTION OF CLOSTRIDIUM DIFFICILE - The invention concerns a screening method for the detection of | 2015-03-26 |
20150087543 | Device, Array, And Methods For Disease Detection And Analysis - A device and array coupled to capture molecules are provided. Specifically, the device and array can be used for detecting the presence and concentration of biomarkers in a sample from a subject. The device and array can also allow the use of a method for scoring a sample for, e.g., the purpose of diagnosing a disease. The method can also be advantageous to applications where there is a need to accurately determine the disease stage of a subject for the purpose of making therapeutic decisions. | 2015-03-26 |
20150087544 | Methods and Systems for Manufacture of Microarray Assay Systems, Conducting Microfluidic Assays, and Monitoring and Scanning to Obtain Microfluidic Assay Results - A method of flowing a fluid with a tracer in a microfluidic channel of an assay device and detecting the tracer for determining the channel location or condition of the channel. | 2015-03-26 |
20150087545 | DETECTION OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS IN BIOLOGICAL SAMPLES - Disclosed are methods of identifying a methicillin-resistant | 2015-03-26 |
20150087546 | SEQUENCE, TECHNIQUE PLATFORM, AND METHOD FOR IN VITRO DETECTING CLOSTRIDIUM DIFFICILE RIBOTYPE 027 - The invention relates to a sequence, a technique platform, and a method for in vitro detecting | 2015-03-26 |
20150087547 | METHOD FOR SEALING SUBSTANCES, METHOD FOR DETECTING TARGET MOLECULE, ARRAY, KIT, AND TARGET MOLECULE DETECTION DEVICE - [Problem to be Solved] | 2015-03-26 |
20150087548 | MARKER SEQUENCES FOR RHEUMATOID ARTHRITIS AND USE THEREOF - The present invention relates to new marker sequences for rheumatoid arthritis and the diagnostic use thereof together with a method for screening of potential active substances for rheumatoid arthritis by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for rheumatoid arthritis, in particular a protein biochip and the use thereof. | 2015-03-26 |
20150087549 | METHODS OF USING TISSUE BIOMARKERS FOR INDICATION OF PROGRESSION FROM BARRETTS ESOPHAGUS TO ESOPHAGEAL ADENOCARCINOMA - A method of diagnosing progression from Barrett's esophagus toward esophageal dysplasia can include: obtaining miRNA from a test subject having Barrett's esophagus; assaying for miRNA biomarker selected from one or more of miR-15b or miR-486-5p; and determining whether one or more of miR-15b or miR-486-5p provide an indication of progression toward esophageal dysplasia in the test subject. The method can include determining an amount of one or more of miR-15b or miR-486-5p. The method can include determining a modulation in amount of one or more of miR-15b or miR-486-5p. The method can include comparing the one or more of miR-15b or miR-486-5p with a positive control or a negative control. | 2015-03-26 |
20150087550 | Apparatus and Methods for Parallel Processing of Micro-Volume Liquid Reactions - Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus. | 2015-03-26 |
20150087551 | METHODS AND SYSTEMS FOR SAMPLING, SCREENING, AND DIAGNOSIS - Apparatus, systems, and methods for detecting, screening and sampling of cells are disclosed. | 2015-03-26 |
20150087552 | METHODS FOR SCREENING VOLTAGE-GATED PROTEINS - In one aspect, the invention relates to a method for identifying a compound which modulates the activity of a voltage-gated protein. In certain embodiments, the voltage gate protein is a voltage-gated ion channel. In certain embodiments, the voltage-gated protein is a voltage sensitive phosphatase. In certain embodiments, the voltage-gated protein used in conjunction with the methods of the invention is modified to altered permeability or voltage sensitivity. | 2015-03-26 |
20150087553 | EARLY TRIMESTER SCREENING FOR EARLY- AND LATE-ONSET PREECLAMPSIA - The present invention is directed to methods for predicting a pregnant woman's risk of developing early-onset preeclampsia or late-onset preeclampsia. The methods are based on measuring one or more metabolites obtained from a pregnant woman's bodily fluid, such as blood or urine, which were found to be predictive of early-onset preeclampsia and late-onset preeclampsia. | 2015-03-26 |
20150087554 | POLYPEPTIDE MARKERS FOR THE DIAGNOSIS OF ALZHEIMER'S DISEASE - A method for the diagnosis of the probability of Alzheimer's disease in a subject patient comprising the step of determining the presence or absence of at least three polypeptide markers in a sample, wherein the at least three polypeptide markers are at least three different markers selected from markers 1 to 50 (frequency markers) and markers 51 to 279 (amplitude markers), wherein the diagnosis is based on a comparison and ranking of the frequency and/or amplitude of the at least three polypeptide markers to the same at least three polypeptide markers obtained from control subjects with and without Alzheimer's disease. | 2015-03-26 |
20150087555 | METHOD FOR IMMOBILIZING BIOLOGIC MOLECULES ON SOLID SURFACES - The invention provides a method for immobilization of biological molecules such as nucleic acids, peptides and proteins onto the surface of a glass or plastic solid support. | 2015-03-26 |
20150087556 | COMPOSITIONS AND METHODS FOR MAKING cDNA LIBRARIES FROM SMALL RNAs - This disclosure provides methods and compositions for generating cDNA libraries. | 2015-03-26 |
20150087557 | ENZYME COMPOSITION FOR DNA END REPAIR, ADENYLATION, PHOSPHORYLATION - Enzyme compositions and their method of use that provide ready-to-use master mixtures. The compositions comprise a modified thermophilic DNA polymerase lacking 5′-3′ and 3′-5′ exonuclease activity premixed with T4 DNA polymerase, Klenow fragment and T4 polynucleotide kinase and all other necessary components, including reaction buffer and nucleoside triphosphates, required to perform DNA blunting, phosphorylation, and single nucleotide extension reactions in one tube and in two steps. Among other benefits, the mixture of different enzymes, buffers and nucleoside triphosphates is stable during prolonged storage. | 2015-03-26 |
20150087558 | Microfluidic Assay Systems Employing Micro-Particles and Methods of Manufacture - A method of making an assay device comprising providing micro-elements in the form of micro-particles or micro-length tube detection elements and thereafter with an automated tool, picking and placing the micro-elements into open-sided microfluidic channels in a body. | 2015-03-26 |
20150087559 | PDMS Membrane-Confined Nucleic Acid and Antibody/Antigen-Functionalized Microlength Tube Capture Elements, and Systems Employing Them - A microfluidic device comprising a microfluidic channel network sealed on one side by a membrane sheet, the sheet having PDMS defining at least the surface sealing the channel, the membrane sheet on its opposite side sealing one side of a pneumatic channel, the pneumatic channel arranged to enable pneumatic deflection of a deflectable portion of the membrane sheet into contact with an opposed surface to control flow in a channel of the network, the membrane sheet confining in a channel of the network at least one micro-particle, micro-length tube or glass nano reactor, functionalized with a capture agent, that has been inserted into that channel. A microfluidic device having a microfluidic channel containing at least two micro-particles, micro-length tubes or glass nano reactors, one functionalized with nucleic acid and another with antibody or antigen. A microfluidic device having a microfluidic channel containing at least one micro-length tube or glass nano reactor functionalized to capture nucleic acid, the device constructed to enable recovery of the nucleic acid captured by the device. | 2015-03-26 |
20150087560 | POLYGLYCOLIC ACID RESIN SHORT FIBERS FOR USE IN WELL TREATMENT FLUID - Polyglycolic acid resin short fibers for a well treatment fluid, the fibers having the following characteristics of (a) to (e): (a) an outside diameter of 5 to 300 μm; (b) a fiber length of 1 to 30 mm; (c) fineness of 0.1 to 25 D; (d) strength of 1 to 20 gf/D; and (e) a ratio of an area of the polyglycolic acid resin with respect to an area of a circle circumscribing a cross section of the fibers being from 10 to 95%; and a well treatment fluid containing the polyglycolic acid resin short fibers for a well treatment fluid. | 2015-03-26 |
20150087561 | GAS HYDRATE INHIBITORS AND METHODS FOR MAKING AND USING SAME - Nitrate brine compositions reduce hydrate formation in flowlines under conditions conducive for hydrate formation in the absence of the nitrate brines, where the nitrate brines include compatible anti-corrosion system. | 2015-03-26 |
20150087562 | GAS HYDRATE INHIBITORS AND METHODS FOR MAKING AND USING SAME - Phosphate brine compositions reduce hydrate formation in flowlines under conditions conducive for hydrate formation in the absence of the phosphate, where the phosphate brines include a compatible anti-corrosion system and may include nitrate brines. | 2015-03-26 |
20150087563 | FLUID FORMULATIONS FOR CLEANING OIL-BASED OR SYNTHETIC OIL-BASED MUD FILTER CAKES - A treatment composition may contact an oil-based mud (OBM) filter cake formed over at least part of a wellbore for incorporating more oil and/or filter cake particles into the treatment composition as compared to an otherwise identical filter cake absent the treatment composition. The treatment composition may include, but is not limited to, a surfactant, an aqueous-based fluid, an agent, an optional second acid, and combinations thereof. The agent may be or include long chain alcohols, phenol derivatives, fatty esters, a first acid, and combinations thereof. The first acid may be or include citric acid, oleic acid, tartaric acid, stearic acid, linoleic acid, linolenic acid, aromatic dicarboxylic acids, oxalic acid, malonic acid, succinic acid, glutaric acid, boric acid, adipic acid, a diacid, a triacid, a tetraacid, and combinations thereof. | 2015-03-26 |
20150087564 | NOVEL METHOD FOR ENHANCING FRACTURE CONDUCTIVITY - Propping compositions comprising: a hardenable, liquid external phase comprising an element selected from the group consisting of: a cement, a cement foam, a polymer, a resin, an aluminum, a flowable carrier fluid, and any combination thereof; and an internal phase that is either gas or liquid and that is immiscible with the external phase; wherein the internal phase exits the propping composition as the hardenable external phase hardens, leaving behind an hardened, interconnected porous network. Some propping compositions may require contact with a treatment for removal from the hardenable external phase and the treatment for removal may comprise at least one material selected from the group consisting of: an acid, a base, a chelant, an oxidizer, a solvent, and any combination thereof. | 2015-03-26 |
20150087565 | Treatment of underground formations with gels - The present invention relates to the formation of a gel within a medium M, in particular within an underground formation, which comprises the following steps: (EI) a basic compound C is added to a fluid latex L comprising dispersed particles of a polymer P, bearing ester side functions, said basic compound C being added in an amount suitable for hydrolysing at least one part of said ester side functions into carboxylic acid and/or alcohol functions, as a result of which a modified latex L′ is obtained, the viscosity of which gradually increases with time from the addition of the compound C up to the formation of a gel; then (E2) the resulting modified latex is introduced into the medium M before the formation of the gel and the gel is left to form within the medium M. | 2015-03-26 |
20150087566 | Tribological Synthesis Method for Producing Low-Friction Surface Film Coating - An article of method of manufacture of a low friction tribological film on a substrate. The article includes a substrate of a steel or ceramic which has been tribologically processed with a lubricant containing selected additives and the additives, temperature, load and time of processing can be selectively controlled to bias formation of a film on the substrate where the film is an amorphous structure exhibiting highly advantageous low friction properties. | 2015-03-26 |
20150087567 | FUEL ECONOMY ENGINE OIL COMPOSITION - The present invention is directed to a lubricating oil additive containing a vicinal diol and a particular detergent blend typically is low viscosity base oils whereby exhibiting improved fuel economy. In this respect, disclosed is a lubricating oil composition comprising: a major amount of base oil of lubricating viscosity; a friction modifier which is selected from the group consisting of C | 2015-03-26 |
20150087568 | ASHLESS LUBRICANT COMPOSITION - A lubricant composition with improved antioxidant capability is provided by way of an additive composition containing a metal free sulfur-containing compound, an aromatic amine, and a hindered amine. Particularly effective metal-free sulfur-containing compounds include ashless dithiocarbamates, such as methylenebis(dibutyldithiocarbamate), and sulfurized fatty acids. | 2015-03-26 |
20150087569 | ESTOLIDE AND LUBRICANT COMPOSITIONS THAT CONTAIN ENE AND DIELS ALDER COMPOUNDS - Provided herein are compositions containing at least one estolide compound and at least one ene and/or Diels Alder compound. In certain embodiments, the addition of at least one ene and/or Diels Alder compound to an estolide-containing composition may improve the cold temperature, viscometric, and/or anti-wear properties of the composition. | 2015-03-26 |
20150087570 | TWO-CYCLE LUBRICANTS COMPRISING ESTOLIDE COMPOUNDS - Estolide compounds and compositions, including two-cycle lubricating compositions comprising at least one estolide compound. Exemplary two-cycle lubricating compositions comprise an estolide base oil and an additive package. | 2015-03-26 |
20150087571 | METHOD OF PREVENTING A FOUL ODOR IN AUTOMOTIVE SERVICE STATIONS - A method of preventing foul odors in an automotive service station comprising mixing a disinfectant which is effective against bacteria and algae into water used to make a glass cleaner solution which is stored in squeegee buckets in the automobile service station. | 2015-03-26 |
20150087572 | AUTOMATIC DISHWASHING DETERGENT COMPOSITION - The present invention is in the field of automatic dishwashing detergent compositions, as well as methods of making and using same. In particular, it relates to an automatic dishwashing detergent composition comprising a new protease. The automatic dishwashing detergent composition provides improved cleaning and finishing. In particular the composition of the invention provides better proteinaceous removal at the same level of other proteases available in the market. This also alternatively allows for the use of a lower level of the protease of the invention and therefore a more cost effective composition. | 2015-03-26 |
20150087573 | Compositions and Methods Comprising Alpha-Amylase Variants with Altered Properties - Described are compositions and methods relating to variant alpha-amylasess having altered biochemical properties and advantageous performance characteristics as compared to a reference alpha-amylase. The variants are suitable for use in various industrial applications such as starch conversion, ethanol production, laundry, dishwashing, pulp and paper production, textile desizing, and/or sweetener production. | 2015-03-26 |
20150087574 | LAUNDRY DETERGENT PARTICLES - The present invention provides lenticular or disc detergent particles comprising (i) surfactant, (ii) inorganic salts, (iii) pigment, wherein the inorganic salts and the pigment are present on the detergent particle as a coating and the surfactant is present as a core. The particles show reduced staining. | 2015-03-26 |
20150087575 | RELEASING A CLEANING AGENT WITH AN ENCAPSULATION MATERIAL - Compositions and apparatus are provided for releasing a cleaning agent with an encapsulation material. An abrasive material and an encapsulation material are disposed within a cleaning product. The encapsulation material is configured to release contents in a cleaning event. A cleaning agent is sorbed by the encapsulation material and configured to be released from the encapsulation material during the event. | 2015-03-26 |
20150087576 | COMPOSITIONS ASSOCIATED WITH AND METHODS OF MANAGING NEUTROPHIL MOVEMENT USING SERUM AMYLOID P (SAP) - The disclosure also relates to a method of reducing the number of neutrophils in a body region by administering a Serum Amyloid P (SAP) composition in an amount and for a time sufficient to suppress neutrophil movement into the body region. In particular, it relates to a method of reducing the number of neutrophils in a body region suffering from an acute injury or from a chronic or long-term disease. Further, the disclosure relates to a method of increasing the number of neutrophils in a body region by administering an anti-SAP antibody or material able to bind SAP. The disclosure further relates to compositions usable with these methods. | 2015-03-26 |
20150087577 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH CXCR4 ANTAGONIZING ACTIVITY - Template-fixed β-hairpin peptidomimetics of the general formula (I) | 2015-03-26 |
20150087578 | Inflammation Inhibiting Compounds - The present invention relates to the use of compounds selected from the group consisting of Lys-(D)Pro-Thr, N-acyl Lys-(D)Pro-Thr, C-amide Lys-(D)Pro-Thr, and C-esters of Lys-(D)Pro-Thr; or a pharmaceutically acceptable salt of said compound for the treatment of inflammatory disorders. The invention also relates to the use of αMSH for inducing tolerance. | 2015-03-26 |
20150087579 | ANTIMICROBIAL PEPTIDES - A novel antimicrobial peptide includes at least eight successive amino acids, the peptide exhibiting a sequence having the following formula: Ter | 2015-03-26 |
20150087580 | ANTIMICROBIAL CATIONIC PEPTIDES AND FORMULATIONS THEREOF - Compositions and methods for making and using therapeutic formulations of antimicrobial cationic peptides are provided. The antimicrobial cationic peptide formulations may be used, for example, in the treatment of microorganism-caused infections, which infections may be systemic, such as a septicemia, or may be localized, such as in acne or an implanted or indwelling medical device. | 2015-03-26 |
20150087581 | Immunosuppression Modulating Compounds - The present invention provides immunosuppression compounds to inhibit the programmed cell death 1 (PD1) signalling pathway. The present invention further provides peptide based compositions for treatment of cancer or treatment of infections via immunopotentiation caused by inhibition of immunosuppressive signaling induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient. Further, the invention provides an application of the compositions containing the peptide moieties for preventive and/or therapeutic agents for cancer, cancer metastasis, immunodeficiency, an infectious disease or the like and an application of peptide moieties as a testing or diagnostic agent or a research agent for such a disease. | 2015-03-26 |
20150087582 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING ORAL DISEASES - Compositions comprising iron-sequestering glycoproteins, chelating agents, stabilizing agents, binding agents, surfactants, fluorides, antimicrobials and a pH adjuster or buffer for the prevention and treatment of oral cavity diseases caused by dental plaque/biofilm, such as dental caries, gingivitis and periodontitis, through anti-infective properties are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive oral bacteria occurring in polymicrobial dental biofilms. The composition may be in the form of wash, rinse, soak, paste, gel, spray, or other suitable form. Additionally, the invention offers an efficient method of delivering the formulated composition containing a PEGylated or fluorinated iron-sequestering glycoprotein and one or two chelating agents or chelating agents alone using either a liposomal or a nanoparticle delivery system. | 2015-03-26 |
20150087583 | DOSING REGIMENS FOR ECHINOCANDIN CLASS COMPOUNDS - The invention features pharmaceutical compositions, methods, and kits featuring dosing gimens and oral dosage formulations for administration of echinocandin class compounds. | 2015-03-26 |
20150087584 | METHOD FOR EFFECTIVE MANAGEMENT OF HELICOVERPA ARMIGERA - The present invention relates to a method for pest management using inhibitory repeat domain IRD 9 (Seq ID No.2) proteinase inhibitor showing enhanced inhibitory activity against the gut proteases of insects. More particularly, the present invention relates to a IRD 9 (Seq ID No.2) proteinase inhibitor from non-host plant | 2015-03-26 |
20150087585 | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS - Derivatives of purine, 3H-imidazo[4,5-b]pyrimidine and 1H-imidazo[4,5-d]pyrazine of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein. | 2015-03-26 |
20150087586 | PEGYLATED C-PEPTIDE - The present invention relates to modified forms of C-peptide, and methods for their use. In one aspect, the modified forms of C-peptide comprise conjugated C-peptide derivatives which exhibit superior pharmacokinetic and biological activity in vivo. | 2015-03-26 |
20150087587 | Process for the Synchronization of Ovulation for Timed Breeding Without Heat Detection - A method for synchronizing ovulation in sows and gilts by a single injection of hormones is disclosed. A hormone, gonadotropin releasing hormone (GnRH), luteinizing hormone (LH), follicle stimulating hormone (FSH), human chorionic gonadotropin (hCG), analogues, derivatives, agonists or combinations thereof is administered to an open sow post weaning at a specific time to stimulate ovulation of mature responsive follicles. The sow is then bred, without heat detection, at a specific subsequent timed interval after injection with hormone, with one or two artificial or natural breedings. In gilts, the hormone is injected at a timed interval from onset of estrus or at a specific timed interval following Prostaglandin F2 | 2015-03-26 |
20150087588 | COMBINATION OF SOMATOSTATIN-ANALOGS WITH 11BETA-HYDROXYLASE INHIBITORS - The present invention relates to a combination which comprises (a) a somatostatin analogue and (b) a 11beta-hydroxylase inhibitor; each in free form or in the form of a pharmaceutical acceptable salt thereof; the use of such a combination for the preparation of a medicament for the treatment of diseases associated with increased stress hormone levels; a commercial package or product comprising such a combination; and to a method of treatment of a warm-blooded animal, especially a human. | 2015-03-26 |
20150087589 | GENES AND PROTEINS ASSOCIATED WITH ANGIOGENESIS AND USES THEREOF - Disclosed is a panel of biomarkers associated with angiogenesis, and the use of such biomarkers (genes, proteins, homologues and analogs thereof) to regulate angiogenesis. Methods for identifying compounds useful for regulating angiogenesis and conditions related thereto are disclosed. | 2015-03-26 |
20150087590 | DIASPIRIN CROSSLINKED PEGYLATED HEMOGLOBIN - PEGylated diaspirin-crosslinked hemoglobin conjugates having high oxygen affinity are described which have enhanced nitrite reductase activity to deliver oxygen, carbon monoxide, nitric oxide or mixtures thereof to tissues to treat various diseases and conditions. | 2015-03-26 |
20150087591 | Novel Composition for Extracorporeal Reduction of Beta-Amyloids and Process for Producing Thereof - The present invention provides a safe, reliable, and economical process for preparing an improved dialysis fluid formulation effective for extracorporeal treatment, through a blood filtration process, of a Beta-Amyloid associated pathological condition in a subject, said process comprises preparing a composition comprising KLVFF peptide, or a variant thereof, as the capturing and binding agent, and a carrier therefor, and mixing said composition with a dialysate solution. The process utilizes a compact, inexpensive, and simple standard dialysis machine that extracorporeally removes Beta-Amyloids without allowing escape of the Beta-Amyloids back into a subject's body, without having to intricately evaluate the performance and characteristics of a dialysis membrane, and without putting the health condition of the subject at risk. | 2015-03-26 |
20150087592 | Sugar Compositions for Treating Hemophilia A and/or Von Willebrand Disease - The invention relates to compositions comprising an isolated sugar for use in the treatment of von Willebrand disease and/or hemophilia A, wherein the sugar is an accessible sugar residue derived from ABO(H) blood group antigen. | 2015-03-26 |
20150087593 | COAGULATION FACTOR VIII WITH REDUCED IMMUNOGENICITY - The invention describes factor VIII molecules with reduced capacity to elicit activation of NKT cells for use in the treatment of congenital and/or acquired haemophilia A and in bleeding disorders. Said factor VIII molecule is obtainable by:
| 2015-03-26 |
20150087594 | INDUCED NEURAL STEM CELLS - The present invention relates to a method of deriving an induced neural stem cell (iNCS) by nuclear reprogramming of a somatic cell, wherein the method comprises a step of contacting the somatic cell with Oct4 protein or a functionally equivalent analogue, variant or fragment thereof for a limited time period, as well as an induced neural stem cell obtained by this method. | 2015-03-26 |
20150087595 | METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT NEUROPATHY - The disclosure relates to methods for treating a subject suffering from hyperalgesia caused by drug-induced neuropathy by administering to the subject an effective amount of an aromatic-cationic peptide. The disclosure also relates to methods for protecting a subject from hyperalgesia caused by drug-induced neuropathy by administering an effective amount of an aromatic-cationic peptide to a subject at risk for developing the condition. | 2015-03-26 |
20150087596 | HUWENTOXIN-IV VARIANTS AND METHODS OF USE - The present invention relates to Huwentoxin-IV variants, polynucleotides encoding them, methods of making and using the foregoing, and methods of alleviating pain with peptide inhibitors of Nav1.7. | 2015-03-26 |
20150087597 | POLYPEPTIDES AND METHODS OF USE - Described herein are fragments of fibronectin and vitronectin and variants thereof that have certain activities, including growth factor-binding activity. Also described are fragments of growth factors that bind to fibronectin and inhibit binding of full-length growth factors to fibronectin. Compositions containing such fragments are useful in cosmetic treatments (e.g., the treatment of wrinkles or UV photodamage of skin), and the treatment of wounds and cancer. | 2015-03-26 |
20150087598 | TREATING MUC1-EXPRESSING CANCERS WITH HELICASE INHIBITORS - The invention provides method of treating cancers that express MUC1 by the administration of eIF4A helicase inhibitors. These inhibitors may advantageously be combined with peptides that inhibit MUC1 oligomerization, or with other standard anticancer therapies such as chemo-, radio- and surgical therapies. | 2015-03-26 |
20150087599 | Peptide-Conjugated Oligonucleotide Therapeutic and Method of Making and Using Same - Conjugates for the efficient delivery of sequence-specific antisense to cells of a selected type for the inhibition of a target protein have the general formula: | 2015-03-26 |
20150087600 | THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE - Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here. | 2015-03-26 |
20150087601 | POLYMER MICELLE COMPLEX INCLUDING NUCLEIC ACID - It is an object of the present invention to provide: a polyion complex that sufficiently retains a photosensitizing substance in serum and is excellent in terms of structural stability; a nucleic acid polyplex as a constituent thereof; and a device and a kit for delivering a nucleic acid into a cell. | 2015-03-26 |
20150087602 | Nutritive Proteins and Methods - Nutritive proteins are provided. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of branch chain amino acid residues to total amino acid residues present in whey protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of leucine residues to total amino acid residues present in whey protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of essential amino acid residues to total amino acid residues present in whey protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things. | 2015-03-26 |
20150087603 | MODIFIED PEPTIDE TOXINS - The invention relates to toxin peptides capable of selectively inhibiting a Kv1.3 potassium channel protein. The toxin peptides of the invention are modified anuroctonus scorpion toxin peptides. | 2015-03-26 |
20150087604 | ANTI-FATTY ACID SYNTHASE POLYPEPTIDE AND USE THEREOF - The present invention relates to a polypeptide that is capable of inhibiting transcription and expression of fatty acid synthase (FAS) and the polynucleotides encoding therefor, as well as the use thereof. Specifically, the present invention relates to a polypeptide that can inhibit the transcription and expression of FAS at the molecular level, the cellular level and in vivo, and can therefore prevent the overexpression of FAS. Said polypeptide and related peptidomimetics, including functional fragments or functional varieties thereof, and the genes encoding therefor, can be widely used in preventing and treating tumors such as liver cancer, and diseases closely related to the metabolism of fatty acid synthase, such as fatty liver and obesity. | 2015-03-26 |
20150087605 | Compositions and Methods Comprising Carboxylic Acid-Containing Small Molecules - Disclosed are compositions and methods for treating anthrax, inhibiting anthrax toxins and inhibiting anthrax toxin-induced cytotoxicity. Carboxylic acid-containing small molecules can be used in the methods and compositions disclosed herein, for example, sulindac and derivatives thereof may be used. Methods of screening for carboxylic acid-containing small molecules that can be used to treat anthrax are disclosed. Targeting the anthrax toxin reduces the risks of anthrax spores. | 2015-03-26 |
20150087606 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING AMYLOID BETA PEPTIDE-ASSOCIATED DISEASES OR CONDITIONS - A pharmaceutical composition containing isoacteoside to the acteoside is provided, which is able to inhibit formation, accumulation or aggregation of amyloid β peptides, and is thus useful in preventing or treating amyloid beta peptide-associated diseases or conditions, wherein a weight ratio of the isoacteoside to the acteoside is 4:1 to 1:4. | 2015-03-26 |
20150087607 | MICRORNA COMPOSITIONS AND METHODS - Provided herein are compositions comprising oligomeric compounds. In certain embodiments, the oligomeric compounds are useful as miRNA mimics. The oligomeric compounds may mimic the activity of miR-34. Also provided herein are methods for the treatment of cancer. | 2015-03-26 |
20150087608 | Methods and Devices for Treating Conditions Associated with Autonomic Dysfunction - Methods and devices treating an autonomic nervous system associated disease condition in a subject are provided. Aspects of the invention include inducing one or more physiological response selected from the group consisting of sweating, gastric emptying, enhanced heart rate variability and enhanced quantitative sensory test responsiveness in a manner sufficient to modify the autonomic nervous system so as to treat the subject for the disease condition. The methods and devices find use in a variety of applications, e.g. in the treatment of subjects suffering from conditions arising from disorders of the autonomic nervous system. | 2015-03-26 |
20150087609 | CYTOTOXIC-DRUG DELIVERING MOLECULES TARGETING HIV (CDM-HS), CYTOTOXIC ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS AND METHODS OF USE - The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as CDM-Hs, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by introducing cytotoxic moieties to gp120-expressing cells, thereby causing cell death and preventing cell infection and spread of HIV. It is shown that CDM-Hs bind to gp120 and gp-120 expressing cells competitively with CD4, and these compounds cause cell death of HIV-infected cells, thereby decreasing viral infectivity. Compounds and methods are described herein. | 2015-03-26 |
20150087610 | Method of Modifying Fertility - The present invention provides methods and compositions for modifying fertility in a male mammalian subject by contacting the subject's testis cells, germ cells or sperm with a sufficient amount of a composition comprising a ligand that binds, activates, or inhibits activation of, a TAS2R receptor expressed on the cells. Also described are methods for screening a test molecule for its effect on fertility by examining changes in male germ cells, testis cells or sperm resulting from contact with a molecule that binds, activates, or inhibits activation of, a TAS2R receptor expressed on the cells. Compositions for modifying fertility in a mammalian subject, e.g., contraceptive products, include a ligand that binds, inhibits or activates a TAS2R receptor in a pharmaceutically acceptable carrier. | 2015-03-26 |
20150087611 | Multi-step Connective Tissue Stabilization Method and Stabilized Tissue Formed Thereby - A multi-step stabilization method for connective tissue is described. Stabilized tissues can exhibit increased resistance to degradation due to enzyme activity, fatigue and storage. The multi-step method includes a first step during which the tissue can be incubated with a glycosaminoglycanase inhibitor, a second step during which the tissue can be incubated with a crosslink activator and/or a phenolic compound, and a third step during which the tissue can be incubated with a second crosslink activator. | 2015-03-26 |