13th week of 2015 patent applcation highlights part 54 |
Patent application number | Title | Published |
20150087813 | LIGAND - The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity. | 2015-03-26 |
20150087814 | CHEMOENZYMATIC GLYCOENGINEERING OF ANTIBODIES AND FC FRAGMENTS THEREOF - The present invention provides for recombinant Endo-S mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sialylated oxazoline or synthetic oligosaccharide oxazoline is added to a core fucosylated or nonfucosylated GlcNAc-protein acceptor. Such recombinant Endo-S mutants are useful for efficient glycosylation remodeling of IgGl-Fc domain to provide different antibody glycoforms carrying structurally well-defined Fc N-glycans. | 2015-03-26 |
20150087815 | VACCINE COMPOSITIONS - The present disclosure relates to vaccine compositions, particularly KLH-peptide conjugates, and methods of making such compositions. The present disclosure further relates to methods of reducing abnormal cell growth using the compositions described herein. | 2015-03-26 |
20150087816 | DOPED MATERIALS FOR REVERSE PHASE CHROMATOGRAPHY - A material for reverse phase chromatography comprises surface modifying apolar and charged groups bound to a solid support, said charged groups being present in amounts of about 0.25 to about 22% of the surface modifying groups, or in amounts of about 0.01 μmol/m | 2015-03-26 |
20150087817 | REACTIVE MULTI-FUNCTIONAL ADDITIVES FOR COATINGS COMPOSITIONS - A composition comprising: | 2015-03-26 |
20150087818 | CHIMERIC IL-1 RECEPTOR TYPE I AGONISTS AND ANTAGONISTS - Featured herein are non-naturally occuring cytokine domains that can be used, inter alia, to modulate cellular signalling responsive to interleukin-1 receptor I (IL-1RI), to treat disorders, and to detect and/or bind to cellular receptors, as well as other agents. Exemplary cytokine domains can contain amino acid residues from at least two parental cytokines domains, for example, receptor binding features, surface features, β strands, and loops from at least two parental cytokines domains. | 2015-03-26 |
20150087819 | ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) - Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described. | 2015-03-26 |
20150087820 | MICROFLUIDIC REACTORS FOR OLIGONUCLEOTIDE SYNTHESIS - The present disclosure generally pertains to systems and methods for the chemical synthesis of micro-quantities of oligonucleotides or other chemical molecules. The system includes a reusable glass micro-reactor containing a paramagnetic solid support, a magnet, an electronic drive controller and an optical spectroscopy system capable of driving a plurality individual reactors. The system utilizes the electroosmotic movement of reactants through microfluidic channels. Spectrophotometric monitoring of the reaction products allows for the real-time determination of synthesis yield. | 2015-03-26 |
20150087821 | Benzimidazole Compounds And Their Use As Chromatographic Ligands - The present invention provides a new method for isolation and/or purification of immunoglobulins from a solution containing one or more immunoglobulins using a solid phase matrix represented by the formula: M-SP-L, wherein M is designates a matrix backbone, SP designates a spacer and L designates a substituted benzimidazole ligand. | 2015-03-26 |
20150087822 | ANTHOCYANIDIN COMPLEX - The invention relates to a complex of pure anthocyanidin and a sulfoalkyl ether β-cyclodextrin, which complex can be formulated as an aqueous solution and as a solid, and a method for producing such a complex. Complexes according to the invention are storage-stable and can be well formulated as an aqueous solution. | 2015-03-26 |
20150087823 | TRANS-2-DECENOIC ACID DERIVATIVE AND DRUG CONTAINING SAME - The present invention relates to a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical agent containing the compound as an active ingredient. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt, which is the compound of the present invention, is specifically represented by the general formula (I): | 2015-03-26 |
20150087824 | NOVEL PRODUCTION METHOD FOR ISOQUINOLINE DERIVATIVES AND SALTS THEREOF - The present invention provides a method capable of industrially producing a target product, i.e., a compound represented by the aforementioned formula (I) or a salt thereof, which is useful for preventing and treating cerebrovascular disorders such as cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage, and cerebral edema, particularly for preventing and treating glaucoma, at high yield even on a large scale without imposing a negative impact on the environment. The present invention provides a method for producing a compound represented by formula (I) or a salt thereof, wherein the method comprises a step of reacting a compound represented by formula (III) or a salt thereof with a compound represented by formula (II) in the presence of at least one solvent selected from the group consisting of a nitrile solvent, an amide solvent, a sulfoxide solvent, and a urea solvent, and a base. | 2015-03-26 |
20150087825 | SPIROCYCLIC DIGYDRO-THIAZINE AND DIHYDRO-OXAZINE BACE INHIBITORS, AND COMPOSITIONS AND USES THEREOF - Compounds are provided having a structure according to Formula (I): wherein A | 2015-03-26 |
20150087826 | SPIROCYCLIC DIGYDRO-THIAZINE AND DIHYDRO-OXAZINE BACE INHIBITORS, AND COMPOSITIONS AND USES THEREOF - Compounds are provided having a structure according to Formula (I): wherein A | 2015-03-26 |
20150087827 | METHOD FOR THE PREPARATION OF TRIAZOLE COMPOUNDS - The present invention relates to a process for preparing 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-ol (I—enol form) or 2-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one (I—keto form) and sodium 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-olate (II) from 1,2,3-triazole (III), methyl bromoacetate (IV-Me-Br) or ethyl bromoacetate (IV-Et-Br), 4,6-dichloropyrimidine (VIII), morpholine (IX) and hydrazine (XII). | 2015-03-26 |
20150087828 | 4-SUBSTITUENT-2-HYDROXYLMORPHOLINE-3-ONE AND PREPARATION METHOD THEREOF - A molecule with neural activities, especially 4-substituent-2-hydroxymorpholin-3-one, as a new intermediate of neurokinin-1 receptor antagonist aprepitant, and preparation method thereof. | 2015-03-26 |
20150087829 | PROCESS AND INTERMEDIATES FOR PREPARING GPR40 AGONISTS - The present invention relates to compounds of formula I | 2015-03-26 |
20150087830 | PROCESS OF A QUATERNARY AMMONIUM SALT - The present invention relates to a novel process for preparing quaternary ammonium salt derivatives. | 2015-03-26 |
20150087831 | SYNTHESIS OF LACTAMS - Methods for the synthesis of lactams are presented whereby a carboxylic acid of the formula HOOC—OR—NH-LG, wherein OR is an organic moiety and LG is a leaving group, is reacted with an acid, such as an organic acid, in particular a strong acid, and a dehydrating agent, which may be one in the same such as a strong acid anhydride, such that the amount of acid added allows for the desired transformation to take place without the loss of the leaving group (LG) before the cyclization, and recovering the lactam. | 2015-03-26 |
20150087832 | PROCESS FOR MAKING BETA 3 AGONISTS AND INTERMEDIATES - The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency. | 2015-03-26 |
20150087833 | ALKYL PHENYL SULFIDE DERIVATIVE AND PEST CONTROL AGENT - An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. | 2015-03-26 |
20150087834 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN PHOSPHATE - The present invention relates to a method for the preparation of sitagliptin phosphate and sitagliptin phosphate anhydrous of Formula (I′) and monohydrate of Formula (I), | 2015-03-26 |
20150087835 | PROCESS FOR THE PREPARATION OF VILAZODONE HYDROCHLORIDE AND ITS AMORPHOUS FORM - The present invention relates to an improved process for the preparation of vilazodone Hydrochloride and a process for preparation of novel pure amorphous form of vilazodone hydrochloride. | 2015-03-26 |
20150087836 | METHOD FOR PRODUCING 5-(DIFLUOROMETHYL)PYRAZINE-2-CARBOXILIC ACID AND PRODUCTION INTERMEDIATE THEREOF - 5-(Difluoromethyl)pyrazine-2-carboxilic acid, which is a raw material for the construction of 5-(difluoromethyl)pyrazine-2-carboxamide, which is a common partial structural motif of the compound having an A production inhibitory action or a BACE1 inhibitory action, can be industrially advantageously produced by decarboxylating 5-[carboxy(difluoro)methyl]pyrazine-2-carboxylic acid, which is obtainable from 5-chloropyrazine-2-carboxylate. | 2015-03-26 |
20150087837 | RHENIUM RECOVERY FROM USED REDUCTIVE AMINATION CATALYSTS - The present invention provides techniques that selectively recover Re from reductive amination catalysts. In particular, the present invention allows Re to be recovered selectively relative to Ni, Co, and/or Cu, and particularly Ni, that are often present on reductive amination catalysts. The present invention uses a combination of oxidation and extraction techniques to selectively recover Re relative to Ni, Co, and/or Cu. Advantageously, the recovery is selective even when using aqueous solutions for extraction. | 2015-03-26 |
20150087838 | PROCESS FOR THE PREPARATION OF RADIOIODINATED 3-FLUOROPROPYL-NOR-Beta-CIT - The invention generally provides processes for the preparation of radioiodinated 3-fluoropropyl-nor-β-CIT. In particular, the process uses an arylsilane intermediate, thus avoiding the use of hexamethylditin, and reducing the number of steps previously required for the preparation of radioiodinated 3-fluoropropyl-nor-β-CIT from anhydroecgonine methyl ester. The invention also relates to the alkylation of a nortropane to the corresponding N-(3-fluoropropyl) analogue using 3-fluoropropanal. | 2015-03-26 |
20150087839 | PROCESS FOR N-DEALKYLATION OF TERTIARY AMINES - The present disclosure provides improved methods for N-dealkylation of tertiary amines, including methods for N-demethylation of alkaloids and opioids, in which the dealkylation reaction is carried out in a solvent comprising a tertiary alcohol. The present disclosure also provides improved processes for preparing semi-synthetic opioids that incorporate the disclosed methods for N-dealkylation of tertiary amines. | 2015-03-26 |
20150087840 | Process for Manufacturing Naphthyridine Derivatives - The invention relates to a new process suitable for manufacturing the compounds of formula I (I) wherein W is H, Br, Cl or methyl, which are synthetic intermediates useful in the preparation of antibiotic compounds. | 2015-03-26 |
20150087841 | SYNTHESIS OF MSE-FRAMEWORK TYPE MOLECULAR SIEVES - A method of synthesizing a crystalline molecular sieve having an MSE framework type comprises crystallizing a reaction mixture comprising a source of water, a source of an oxide of a tetravalent element, Y, selected from at least one of silicon, tin, titanium, vanadium, and germanium, optionally a source of a trivalent element, X, a source of an alkali or alkaline earth metal, M, and a source of organic dications, Q, such as 3-hydroxy-1-(4-(1-methylpiperidin-1-ium-1-yl)butyl)quinuclidin-1-ium, 3-hydroxy-1-(5-(1-methylpiperidin-1-ium-1-yl)pentyl)quinuclidin-1-ium, 1,1′-(butane-1,4-diyl)bis(1-methylpiperidin-1-ium), 1,1′-(pentane-1,5-diyl)bis(1-methylpiperidin-1-ium), 1,1′-(hexane-1,6-diyl)bis(1-methylpiperidin-1-ium), and 1,1′-((3as,6as)-octahydropentalene-2,5-diyl)bis(1-methylpiperidin-1-ium). | 2015-03-26 |
20150087842 | Process For The Preparation Of Benzimidazole Derivatives And Salts Thereof - Provided are novel salts of benzimidazole derivatives, preferably salts of benzimidazole derivatives which are useful intermediates in the synthesis of pure 1-methyl-2-[N-[4-(N-n-hexyloxycarbonylamidino)phenyl]aminomethyl]benzimidazol-5-yl-carboxylicacid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide and its salts. | 2015-03-26 |
20150087843 | Process for preparing N-substituted 1H-pyrazole-5-carboxylate compounds and derivatives thereof - The present invention relates to a process for preparing an N-substituted 1H-pyrazole-5-carboxylate compound of the formula (I-A) | 2015-03-26 |
20150087844 | RIBONUCLEOTIDE REDUCTASE INHIBITORS AND METHODS OF USE - Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme, as well as methods of synthesizing these novel compounds. The compounds may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases. | 2015-03-26 |
20150087845 | PROCESS FOR PREPARATION OF SUBSTITUTED 3'-HYDROAZINO-DIPHENYL-3-CARBOXYLIC ACID COMPOUNDS - The present invention provides a process for the preparation of substituted 3′-hydrazino-biphenyl-3-carboxylic acid compounds. The present invention further provides a process for the preparation of 3′-{N′-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]hydrazino}-2′-hydroxybiphenyl-3-carboxylic acid, its intermediate compounds and pharmaceutically acceptable salts thereof. | 2015-03-26 |
20150087846 | PPARs AGONIST ACTIVITY ENHANCING DRUG - A lifestyle disease improving drug that enhances PPARα, δ and γ agonist activities that includes a compound having the lactone structure in accordance with the chemical formula 6-alkyl-5,6-dihydro-2H-pyran-2-one, the alkyl containing 4, 5, or 6 carbons, and a method for synthesizing the compound. The method includes adding, stepwise, a butyllithium-hexane solution to a diisopropylamine-tetrahydrofuran solution, and then a 6-alkyltetrahydro-2H-pyran-2-one-tetrahydrofuran solution, wherein the alkyl contains 4, 5, or 6 carbons, adding a phenylselenyl choloride-tetrahydrofuran solution to produce a reaction mixture with a phenylselenide, extracting and purifying the phenylselenide, preparing a phenylselenide-tetrahydrofuran solution with the purified phenylselenide, and adding sodium bicarbonate and an aqueous hydrogen peroxide solution to the phenylselenide-tetrahydrofuran solution to produce a reaction mixture including the compound. | 2015-03-26 |
20150087847 | COMPOUND HAVING 2-FLUOROPHENYLOXYMETHANE STRUCTURE - There is provided a compound having a good miscibility with another liquid crystal compound and having a combination of a low viscosity (η), high storage stability, and high T | 2015-03-26 |
20150087848 | ACID-FUNCTIONALIZED POLYOLEFIN MATERIALS AND THEIR USE IN ACID-PROMOTED CHEMICAL REACTIONS - An acid-functionalized polyolefin material that can be used as an acid catalyst in a wide range of acid-promoted chemical reactions, wherein the acid-functionalized polyolefin material includes a polyolefin backbone on which acid groups are appended. Also described is a method for the preparation of the acid catalyst in which a precursor polyolefin is subjected to ionizing radiation (e.g., electron beam irradiation) of sufficient power and the irradiated precursor polyolefin reacted with at least one vinyl monomer having an acid group thereon. Further described is a method for conducting an acid-promoted chemical reaction, wherein an acid-reactive organic precursor is contacted in liquid form with a solid heterogeneous acid catalyst comprising a polyolefin backbone of at least 1 micron in one dimension and having carboxylic acid groups and either sulfonic acid or phosphonic acid groups appended thereto. | 2015-03-26 |
20150087849 | SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELL - The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | 2015-03-26 |
20150087850 | BIO-POLYOLS FOR BIO-LUBRICANT AND BIO-POLYMER AND METHODS FOR THE PREPARATION THEREOF - A method for producing an ester polyol, comprising transesterifying a first ester polyol with a primary polyol to produce a second ester polyol, wherein the second ester polyol has a higher hydroxyl value than the first ester polyol. | 2015-03-26 |
20150087851 | METHOD FOR RECYCLING ORGANIC RUTHENIUM COMPOUND FOR CHEMICAL VAPOR DEPOSITION - The present invention is a method for recycling an organic ruthenium compound for chemical vapor deposition, wherein an unreacted organic ruthenium compound is extracted from a used raw material through a thin film formation process. The method includes the following steps (a) to (c). (a) A modification step in which the used raw material and a hydrogenation catalyst are brought into contact with each other in a hydrogen atmosphere, thereby hydrogenating an oxidized organic ruthenium compound in the used raw material. (b) An adsorption step in which the used raw material and an adsorbent are brought into contact with each other, thereby removing impurities in the used raw material. (c) A restoration step in which the used raw material is heated at a temperature that is not lower than −100° C. and not higher than −10° C. with respect to the decomposition temperature of the organic ruthenium compound for eight hours or more, thereby adjusting the ratio of the isomers of the organic ruthenium compound in the used raw material. | 2015-03-26 |
20150087852 | FUNCTIONALIZED SINGLE-WALLED NANOTUBES AND METHODS THEREOF - Described are single-walled metal oxide nanotubes having a plurality of organic functional units or moieties bonded generally in a covalent manner to the inner wall of the single-walled nanotubes. Functionalization of the single-walled metal oxide nanotubes is performed in a single-step during synthesis of the nanotubes. The organic functional units are found dispersed throughout the length of the inner wall and not sterically hindered or contained at only the mouth or ends of the single-walled metal oxide nanotubes. | 2015-03-26 |
20150087853 | SILICONE COMPOUND HAVING A RADICAL-POLYMERIZABLE GROUP AND A METHOD FOR THE PREPARATION THEREOF - A purpose of the present invention is to provide a polymerizable group-containing silicone compound which is liquid at room temperature, has good handling properties and compatibility with other polymerizable monomers. The present invention provides a silicone compound represented by the general formula (1) which has a structure represented by the following formula (2) or (3): | 2015-03-26 |
20150087854 | METHOD FOR PRODUCING CARBAMATE COMPOUND, CARBAMATE COMPOUND, AND METHOD FOR PRODUCING ISOCYANATE COMPOUND USING SAME - The present invention relates to a method of producing a carbamate compound, comprising reacting a fluorine-containing carbonic diester compound represented by formula (1) and a non-aromatic diamine compound represented by formula (2) without using a catalyst, to thereby produce a carbamate compound represented by formula (3), and a method of producing an isocyanate compound represented by formula (20) from the carbamate compound without using a catalyst, wherein R represents a fluorine-containing monovalent aliphatic hydrocarbon group, and A represents a divalent aliphatic hydrocarbon group, a divalent alicyclic hydrocarbon group or a divalent aromatic-aliphatic hydrocarbon group. | 2015-03-26 |
20150087855 | KILLING OF BED BUGS - Killing of bed bugs is accomplished by bringing the bed bugs into contact with a toxic amount of at least one of the compounds of the structure (I) | 2015-03-26 |
20150087856 | MELANIN PRODUCTION INHIBITOR - The present invention provides a melanin production inhibitor containing a compound having a (2-isopropyl-5-methyl)cyclohexyl group or a (2-isopropenyl-5-methyl)cyclohexyl group. | 2015-03-26 |
20150087857 | LIQUID-LIQUID EXTRACTION PROCESS FOR THE PRODUCTION OF ACRYLIC ESTERS - The invention relates to a liquid-liquid extraction process, comprising:
| 2015-03-26 |
20150087858 | CARBON NANOTUBE SUSPENSIONS AND METHODS OF MAKING THE SAME - Carbon nanotube suspensions or dispersions include carbon nanotubes and a functional group attached to an aromatic polycyclic compound on a surface of the carbon nanotubes. The carbon nanotubes in the suspensions or dispersions are pretreated by exposing the carbon nanotubes to a solvent (such as N-cyclohexyl-2-pyrrolidone) and an acid (such as concentrated sulfuric acid). The carbon nanotubes pretreated according to this method can be dispersed or suspended in a solvent to prepare high concentration suspensions, dispersions and/or inks for various applications. | 2015-03-26 |
20150087859 | PROCESSES FOR PRODUCING TEREPHTHALIC ACID - Processes for producing terephthalic acid are disclosed, the processes including a step of combining in a reaction medium para-xylene, a solvent comprising water and a saturated organic acid having from 2-4 carbon atoms, and an oxygen-containing gas, at a temperature for example from about 145° C. to about 175° C., in the presence of a catalyst composition comprising cobalt, manganese, zirconium, and bromine, wherein the zirconium is present in the reaction medium in an amount, for example, from 1 ppm to 50 ppm with respect to the weight of the liquid in the reaction medium. | 2015-03-26 |
20150087860 | PROCESSES FOR PRODUCING ISOPHTHALIC ACID - Processes for producing isophthalic acid are disclosed, the processes including a step of combining in a reaction medium meta-xylene, a solvent comprising water and a saturated organic acid having from 2-4 carbon atoms, and an oxygen-containing gas, at a temperature for example from about 145° C. to about 175° C., in the presence of a catalyst composition comprising cobalt, manganese, zirconium, and bromine, wherein the zirconium is present in the reaction medium in an amount, for example, from about 1 ppm to 50 ppm with respect to the weight of the liquid in the reaction medium. | 2015-03-26 |
20150087861 | METHOD FOR PRODUCING ACROLEIN AND/OR ACRYLIC ACID FROM GLYCEROL - The invention relates to the production of acrolein and/or acrylic acid from glycerol, and more particularly to a method for continuous production of a stream comprising acrolein by dehydration of glycerol, comprising cycles of reaction and regeneration of a dehydration catalyst. | 2015-03-26 |
20150087862 | METHOD FOR STOPPING A REACTION DURING THE PRODUCTION OF AROMATIC AMINES FROM NITROAROMATICS - The present invention relates to A method for producing aromatic amines by the hydrogenation of aromatic nitro compounds. This method comprises:
| 2015-03-26 |
20150087863 | CURING COMPOSITION FOR FLUOROPOLYMERS - Provided is a catalyst composition suitable for curing a fluoroelastomer, the catalyst composition comprising an anion of Formula III: | 2015-03-26 |
20150087864 | METHOD FOR PRODUCING BRANCHED CHAIN ALDEHYDE - A method for producing a branched chain aldehyde, comprising: reacting an aliphatic olefin having a double bond at an end with carbon monoxide and hydrogen using an iodide of a Group 9 metal as a catalyst and at least one or more selected from the group consisting of hydrogen iodide and alkyl iodides as a promoter. | 2015-03-26 |
20150087865 | METHOD FOR PRODUCING SYNTHESIS GAS FOR METHANOL PRODUCTION - Method for producing synthesis gas for methanol production The present invention relates to a method for producing synthesis gas from a hydrocarbon containing feed, which synthesis gas is particularly suitable for subsequent use in methanol production. In this method, a feed ( | 2015-03-26 |
20150087866 | PROCESS FOR THE PRODUCTION OF OLEFINS AND USE THEREOF - The present invention relates to the process of production of olefins by means of the dehydration of light alcohols using ionic liquids as an acidic medium. Furthermore, the present invention relates to the use of such olefins, for example, for the production of polymers and ethylene glycol. | 2015-03-26 |
20150087867 | REDUCTION METHOD FOR THE REDUCTION OF CARBON DIOXIDE AND CARBON DIOXIDE DERIVATIVES - A method for the reduction of carbon dioxide and/or carbon dioxide derivatives to methanol comprises the step of hydrogenation carbon dioxide and/or carbon dioxide derivatives in the presence of a Ruthenium-phosphine complex. | 2015-03-26 |
20150087868 | APPARATUS AND METHOD FOR SYNTHESIZING F-18 LABELED RADIOACTIVE PHARMACEUTICALS - The present invention relates to an apparatus for synthesizing F-18 labeled radioactive pharmaceutical. The apparatus for synthesizing F-18 labeled radioactive pharmaceutical includes an F-18 radioactive isotope supplier, a reagent supplier, a polymer precursor cartridge, a first heating unit, a polymer compound cartridge, a synthesizing container, a second heating unit, a water liquid container, a transmitting gas supplier, a cleansing liquid supplier, a connection tube, a plurality of control valves, and a controller. | 2015-03-26 |
20150087869 | CAPTURE OF TRIFLUOROMETHANE USING MOLECUAR SIEVES - A method for capturing trifluoromethane from a gaseous mixture in a vent stream from a chlorodifluoromethane manufacturing process is described. In the method, the gaseous mixture is contacted with a molecular sieve, such as a zeolite or activated carbon, having a pore opening of at least about 5 Angstroms and a Sanderson electronegativity of less than or equal to about 2.75. The method is useful for reducing emissions of trifluoromethane, which has a high global warming potential. | 2015-03-26 |
20150087870 | METHODS OF MAKING CHLORINATED HYDROCARBONS - Methods for the manufacture of 1,1,1,2,3-pentachloropropane from 1,1,1,3-tetrachloropropane and chlorine are disclosed. Improved methods are provided for the manufacture of 1,1,2,3-tetrachloropropene from 1,1,1,2,3-pentachloropropane. Methods are also disclosed for the manufacture of 1,1,2,3-tetrachloropropene from 1,1,1,3-tetrachloropropane and chlorine and for the manufacture of 1,1,2,3-tetrachloropropene from carbon tetrachloride, ethylene, and chlorine. | 2015-03-26 |
20150087871 | Method for Converting Waste Plastic to Lower-Molecular Weight Hydrocarbons, Particularly Hydrocarbon Fuel Materials, and the Hydrocarbon Material Produced Thereby - A method produces a hydrocarbonaceous fluid (a liquid mixture of hydrocarbons, or in other words a mixture of hydrocarbons which is liquid at ambient room temperature and atmospheric pressure), which functionally is a liquid hydrocarbon fuel, from a feed of waste plastic. The method comprises in broad embodiments the steps of: (step 1) melting a feed of substantially solid waste plastic in an aerobic atmosphere (for instance, air) whereby a waste-plastic melt is produced; (step 2) distilling at least a portion of the waste-plastic melt whereby a hydrocarbonaceous distillate is produced; and (step 3) collecting the hydrocarbonaceous distillate. That distillate is generally referred to above as a condensate. In some preferred embodiments, the method includes the step of commutating the feed of substantially solid waste plastic into pieces substantially no greater than about 1.5 cm | 2015-03-26 |
20150087872 | Base Oil Upgrading by Co-Feeding a Ketone or Beta-Keto-Ester Feedstock - This invention discloses a process for making high viscosity index lubricating base oils having a viscosity index of at least 110 by co-feeding a ketone or a beta-keto-ester feedstock with a lubricant oil feedstock directly to a hydrocracking unit to produce a hydrocracked stream. Then at least a portion of the hydrocracked stream is treated under hydroisomerization conditions to produce a high viscosity index lubricating base oil. The process may involve bypassing a hydrotreating or hydrofinishing step, which may result in improved efficiency and economics in producing high viscosity index lubricating base oils. | 2015-03-26 |
20150087873 | Tetramerisation of Ethylene - A process for the tetramerisation of ethylene under solution phase conditions is carried out in the presence of an activated catalyst at a temperature above 80° C. and up to a temperature of about 130° C. The activated catalyst is provided by combining a source of chromium, a ligating compound, which ligating compound includes at least one fluorine substituted hydrocarbyl group, organoheteryl group, or heterohydrocarbyl group, and optionally a catalyst activator or combination of catalyst activators. | 2015-03-26 |
20150087874 | Reactor and Method for Gasifying and/or Cleaning a Starting Material - The invention relates to a reactor for gasifying and/or cleaning a starting material ( | 2015-03-26 |
20150087875 | NANOWIRE CATALYSTS AND METHODS FOR THEIR USE AND PREPARATION - Nanowires useful as heterogeneous catalysts are provided. The nanowire catalysts are useful in a variety of catalytic reactions, for example, the oxidative coupling of methane to C2 hydrocarbons. Related methods for use and manufacture of the same are also disclosed. | 2015-03-26 |
20150087876 | METHODS AND SYSTEMS FOR SEPARATING PARA-XYLENE USING A RADIAL FLOW SIMULATED MOVING BED CHAMBER - Methods and systems for separating para-xylene are disclosed. In one exemplary embodiment, a method for separating para-xylene includes the steps of providing a feed stream including para-xylene and other C | 2015-03-26 |
20150087877 | ENHANCING FLUX OF A MICROPOROUS HOLLOW FIBER MEMBRANE - The present invention includes a system and method for improving oil recovery from a liquid source of oil, comprising: a membrane contactor in contact with a liquid source of oil; a heating/cooling device connected to at least one of the liquid source of oil or a collection fluid; and a membrane contactor system having one or more membrane contactors having a first and a second surface, wherein at least one of the first or second surfaces coalesce one or more oils from the liquid source of oil allowing the coalesced oil to be collected on the opposite surface of the membrane, wherein a temperature differential between the liquid source of oil and the collection fluid enhances the oil recovery at the membrane contactor from the liquid source of oil. | 2015-03-26 |
20150087878 | PROCESS FOR SEPERATING XYLENES BY SIMULATED COUNTER-CURRENT, TREATING A FEED INCLUDING OXYGEN-CONTAINING AROMATIC IMPURITIES OF THE PHENOL TYPE - The present invention describes a process for separating xylenes in simulated counter-current (simulated moving bed, SMB) for the treatment of feeds including oxygen-containing aromatic impurities of the phenol type and/or derivatives thereof, by controlled injection of water in the ingoing streams. | 2015-03-26 |
20150087879 | BENCHMARK SYSTEM FOR RADIATION THERAPY PLANNING - A system for evaluating radiation treatment planning generates a fictitious treatment dose matrix with a quality of dose placement beyond that achievable with physically realizable radiation therapy machines. Such a fictitious treatment dose matrix provides an objective measure that is readily tailored to different clinical situations, and although unattainable, thereby provides a benchmark allowing evaluation of radiation plan goals and the radiation plans between different multiple clinical situations and individuals. | 2015-03-26 |
20150087880 | USE OF A COMPOSITION COMPRISING A POLY-ORGANOSILOXANE - A composition based on a poly-organosiloxane which is suitable for its use as a bolus in radiotherapy treatments. Other possible uses of this composition are the production of an immobilizing mask for radio surgery or cranial stereotaxy treatments and the production of an intraoral depressor. | 2015-03-26 |
20150087881 | RADIOTHERAPY CONTROL APPARATUS AND RADIOTHERAPY CONTROL PROGRAM - [Problem to be Solved] | 2015-03-26 |
20150087882 | METHOD AND APPARATUS FOR MONITORING THE RANGE OF A PARTICLE BEAM - The invention is related to a method for monitoring a range of a particle beam in a target. The method is using gamma detectors for detecting prompt gammas produced in the target. The time differences between the time of detecting a gamma quantum and a time of emission of a particle or a bunch of particles from the radiation device are determined. A statistical distribution of those time difference is used to deduce information related to the range of the beam. The invention is also related to an apparatus for monitoring a range based on measured time profiles of detected prompt gammas. | 2015-03-26 |
20150087883 | TREATMENT THEATER FOR PROTON THERAPY - A theater system for a proton treatment system, including a tunnel structure configured around an isocenter of a proton treatment system, and one or more devices mounted on the tunnel structure to communicate with a patient located on a treatment bed of the proton treatment system. | 2015-03-26 |
20150087884 | RIGID APPARATUS TO REPLACE BEAM STEERING - A proton beam delivery system including a proton beam nozzle to emit a proton beam to a targeted region of a patient, a gantry wheel to support the proton beam nozzle, the gantry wheel being configured to rotate the proton beam nozzle about a rotation axis of the gantry wheel such that the proton beam nozzle emits the proton beam to an isocenter of the gantry wheel corresponding to the targeted region, a beamline deflector configured to be rotated by the gantry wheel to transport the proton beam along a curvilinear path from the rotation axis to the proton beam nozzle using a predetermined power setting of the beamline deflector, and a rigid support structure to support the beamline deflector when the gantry wheel is rotated such that the beam nozzle directs the proton beam to the isocenter from a plurality of radial directions using the same predetermined power setting. | 2015-03-26 |
20150087885 | Method and Apparatus for Measuring, Verifying, and Displaying Progress of Dose Delivery in Scanned Beam Particle Therapy - The present disclosure is directed to systems and methods for real-time control of a charged particle pencil beam system during therapeutic treatment of a patient. In an aspect, the present disclosure is directed to measuring an actual shape, an actual intensity distribution, and an actual location at isocenter of the charged particle pencil beam. The actual data is compared to model treatment data in real time to determine if a statistically significant variance occurs in which case the charged particle pencil beam can be stopped mid-treatment for correction and/or analysis. | 2015-03-26 |
20150087886 | NOVEL BIFUNCTIONAL METNASE/INTNASE INHIBITORS AND RELATED COMPOSITIONS AND METHODS OF TREATMENT OF CANCER - This invention relates to novel cancer treatment compositions and associated therapeutic methods. More particularly, this invention relates in part to small chemical bifunctional inhibitors of DNA replication and repair proteins Metnase and/or Intnase (also termed Gypsy Integrase, Gypsy Integrease-1, Gypsy Retransposon Integrase 1, or GIN-1) that simultaneously damage DNA, and to a therapeutic method that utilizes the inhibitors to increase the effectiveness of cancer treatment protocols, including radiation therapy. | 2015-03-26 |
20150087887 | MULTI-LEAF COLLIMATOR, PARTICLE BEAM THERAPY SYSTEM, AND TREATMENT PLANNING APPARATUS - There are provided a leaf row in which a plurality of leaf plates are arranged in the thickness direction of the row in such a way that the respective one end faces of the leaf plates are trued up and a leaf plate drive mechanism that drives each of the plurality of leaf plates in such a way that the one end face approaches or departs from a beam axis. In each of the leaf plates, a facing side facing a leaf plate that is adjacent to that leaf plate in the thickness direction is formed of a plane including a first axis on the beam axis; the leaf plate drive mechanism drives the leaf plate along a circumferential orbit around the second axis, on the beam axis, that is perpendicular to the beam axis and the first axis. | 2015-03-26 |
20150087888 | Method and system for displaying the electric field generated on the brain by transcranial magnetic stimulation - A visualization surface representative of a portion of the brain at a depth below the head surface of the subject is generated by combining an actual representation of the head surface with an idealized representation of the head surface. The combining is a function of the depth and is performed to minimize in the visualization surface any irregularities existing in the actual head surface of the subject. A display shows the visualization surface overlaid on a volumetric image of the brain, the electric field induced on a region of the visualization surface by a transcranial magnetic stimulation (“TMS”) induction coil device positioned above the head surface and the TMS coil device. By viewing the display, a user of the TMS coil device can interactively position the TMS coil device in relation to the head surface and, for a target site on the brain at a selected depth, determine the position at which the TMS coil device induces a maximum E-field on a visualization surface corresponding to the selected depth. | 2015-03-26 |
20150087889 | BLOOD PUMP - A centrifugal blood pump for circulating blood is provided, wherein an impeller makes no contact at all with a housing and a rotating shaft and moves in a rotating manner with the impeller in a stably levitating state. Also provided is a blood pump in which the impeller rotates at high speed even when the blood pump is reduced in scale. The blood pump contains a magnet of enhanced magnetic force at the inside of a housing and at an outer peripheral surface of an impeller and providing a fixed-interval spacing on the periphery of a bearing section makes it possible to ensure a state where no contact at all is made between the housing, a shaft, and the impeller, and makes it possible to cause the impeller to rotate stably over a long period of time. | 2015-03-26 |
20150087890 | CATHETER SYSTEM AND INTRAVASCULAR BLOOD PUMP COMPRISING SAID CATHETER SYSTEM - A catheter ( | 2015-03-26 |
20150087891 | Osteoconductive Implantable Component for a Bone Conduction Device - An osteoconductive implantable component for use in coupling a bone conduction device to a recipient is provided. The implantable component is configured to be implanted adjacent to a recipient's bone and is configured to promote bone ingrowth and/or ongrowth to interlock the implantable component with the recipient's bone so as to prevent movement of the implantable component with respect to the recipient's skull. | 2015-03-26 |
20150087892 | IMPLANTABLE DEVICE WITH REMOVABLE MAGNET - A cochlear implant system includes a subcutaneous housing which includes a main body and a bottom cover secured to the main body. A central cavity in a center of the subcutaneous housing is formed by a portion of an outer surface of the main body. A magnet is removably inserted into the central cavity and includes a cylindrical body with a central axis aligned with a removal axis of the central cavity, a groove extending circumferentially around the cylindrical body, and a top surface, which includes an outer edge, a plurality of ribs extending radially farther than the outer edge, and a plurality of abutments extending radially farther than the ribs. A compressive ring is seated in the groove of the cylindrical body and engages under a ledge in the central cavity when the magnet is inserted into the central cavity and biases the magnet against removal from the central cavity. | 2015-03-26 |
20150087893 | FLOAT TENT - A float tent can include: a frame having a pool frame portion with a tent frame portion thereof over the pool frame portion; a tent having the tent frame portion, the tent having a closable opening; and a pool having the pool frame portion, the pool having pool sides dimensioned to hold at least 8 inches of water and having a pool base dimension sufficient for a person to lay in the pool without touching pool sides. The tent can include tent walls having an angle that inhibits condensation drip, the angle being with respect to the pool base, such as at least 4.5 degrees. The tent can include a material that is opaque. The float tent can include a heater configured to heat the water to skin temperature of the person. The float tent can include a water circulation pump and filter. | 2015-03-26 |
20150087894 | METHOD AND DEVICE FOR MONITORING AND TREATING SLEEP DISORDERS AND SLEEP-RELATED CONDITIONS - Methods and apparatus for monitoring, diagnosing, and treating sleep disorders such as sleep terrors are provided, which may include any number of features. One feature is an apparatus configured to partially awaken a user to treat a sleep disorder. The apparatus can include one or more sensors configured to monitor a sleep parameter of the user, one or more therapeutic devices configured to apply a therapy to the user to partially awaken the user, and an electronic controller operatively coupled to the sensors and therapeutic devices to determine when to apply the therapy, and how to apply the therapy so as to only partially awaken the user. | 2015-03-26 |
20150087895 | METHOD OF PLACING IMPLANT INDWELLING - A method of placing an implant indwelling in a living body is disclosed. The method can include forming an insertion hole in the living body, the insertion hole extending from a living body surface and passing an obturator foramen on one side and an obturator foramen on the other side, the insertion hole having its end portion on the one side opened in the living body surface and its end portion on the other side closed in relation to the living body surface; inserting a medical tube that permits the implant to be inserted into the medical tube, prior to insertion of the implant; inserting the implant into the medical tube inserted in the insertion hole; and pulling the medical tube out of the insertion hole so that the implant is placed indwelling in the living body. | 2015-03-26 |
20150087898 | CAPSULE ENDOSCOPE MAGNETIC CONTROL SYSTEM - A capsule endoscope magnetic control system includes a control handle assembly, and a capsule endoscope having a controlled unit, a wireless power receiving unit, an image capturing unit, a processing unit, and a wireless communication unit. The control handle assembly includes a magnetic control unit for generating a magnetic field and a wireless power transmission unit for generating electromagnetic waves. After the capsule endoscope is placed inside a test object, the controlled unit fixed to the outside of the capsule endoscope changes the rotational direction of the capsule endoscope according to the changes in the magnetic field. The wireless power receiving unit generates an induced current. The image capturing unit generates an image data, which is received and converted by the processing unit into an image signal, which is transmitted by the wireless communication unit to the control handle assembly. Therefore, the capsule endoscope has a long battery life. | 2015-03-26 |
20150087899 | NESTED CANNULA STARTER ALIGNMENT - A medical system includes a tube ( | 2015-03-26 |
20150087900 | BRONCHOSCOPE ADAPTER AND METHOD - A bronchoscope adapter is configured for one hand operation by providing a slide lock that is captured within a housing and a retaining nut that can be operated with a single finger or thumb. Rotation of the retaining nut is eased by isolating rotational force from a compression block with a spacer ring. | 2015-03-26 |
20150087901 | CATHETER FOR USE WITH AN ENDOSCOPE - Endoscopes, medical devices for use with endoscopes, and methods for making and using endoscopes. An example medical device for use with an endoscope is a catheter having one or more ridges formed on an outer surface thereof. The ridges may interact, for example, with the elevator of an endoscope. | 2015-03-26 |
20150087902 | Phase Contrast Microscopy With Oblique Back-Illumination - A method of creating a phase contrast image is provided. In some embodiments the method comprises illuminating the target region of a sample with a first light source to provide a first oblique back illumination of the target region of the sample, and detecting a first phase contrast image from light originating from the first light source and back illuminating the target region of the sample. In some embodiments the method further comprises illuminating the sample with a second light source to provide a second oblique back illumination of the target region of the sample, and detecting a second phase contrast image from light originating from the second light source and back illuminating the target region of the sample. In some embodiments a difference image of the target region of the sample is created by subtracting the second phase contrast image of the target region of the sample from the first phase contrast image of the target region of the sample. Apparatus for carrying out the methods are also provided. The methods and apparatus find use, for example, in endoscopy. | 2015-03-26 |
20150087903 | ENDOSCOPE SYSTEM AND OPERATING METHOD THEREOF - A V-LED, B-LED, G-LED and R-LED for an endoscope are all driven to apply normal light to an object of interest in a body. An image sensor images the illuminated object and outputs an RGB image signal. A measurement sensor measures a light amount of red light from the R-LED. A light source controller acquires a current value for the R-LED according to a light amount signal from the measurement sensor and a target light amount signal for the R-LED. A normal color converter and the R-LED receive a current of the current value. Each LUT_Mij in the normal color converter is referred to for outputting a matrix coefficient according to the current value of the R-LED. The RGB image signal is converted into a processed image signal by matrix operation according to the matrix coefficient. | 2015-03-26 |
20150087904 | ENDOSCOPE - An endoscope includes a heat influence reducing portion that radiates heat, which is generated with light guiding of a light guide portion via a position near a second lens and conducted to the second lens, to a frame member to reduce a local temperature difference in the second lens in a projecting portion in which a first lens of a front observation window through which an inserting direction for insertion into a lumen is observed and the second lens having a truncated conical shape used for observing a viewing field region of a side observation window through which a direction crossing the inserting direction is observed are arranged. | 2015-03-26 |
20150087905 | ENDOSCOPE HAVING FLEXIBLE TUBE - In an endoscope, a flexible device of an elongated tube has a variable stiffness device. The variable stiffness device includes a movable control wire and a coil spring, to which compression force is applied to change stiffness. There occur changes in stiffness of the flexible device in plural radial directions of the coil spring at an equal point in an axial direction. The variable stiffness device is so constructed that a difference between maximum and minimum levels of stiffness of the variable stiffness device is set at most 0.2 time as much as stiffness of the flexible device with internal structures other than the variable stiffness device. Thus, unexpected grip feeling in manipulation of an operator at the time of advance can be removed in relation to undulating motion of the coil spring. | 2015-03-26 |
20150087906 | ATRAUMATIC ARTHROSCOPIC INSTRUMENT SHEATH - A removable, resilient atraumatic sheath for arthroscopic instruments. The sheath covers sharp edges on the arthroscopic instrument, particularly the distal tip of the rigid cannula, and thereby protects tissue and objects near a surgical site from accidental trauma. The sheath may be provided in the form of an inflow/outflow sheath that allows a surgeon to irrigate and drain a surgical field without the use of a separate irrigation instrument. The distal tip of the sheath may comprise a dissimilar material of a higher modulus of elasticity than the material comprising the remainder of the tube. | 2015-03-26 |
20150087907 | OBLONG ENDOSCOPE SHEATH - An endoscope sheath comprising: a proximal end; a distal end having a distal end region; a surface extending between and connecting the proximal end and the distal end; and a plurality of positioning devices located along the surface; wherein the sheath is configured to (1) receive all or a portion of an endoscope having a cylindrical end and (2) provide a conduit for communicating fluid between the proximal end of the sheath and the distal end of the sheath when the endoscope is inserted inside the sheath; and wherein the distal end region of the sheath includes the plurality of positioning devices that secure the cylindrical end of the endoscope against a portion of an inner wall of the surface extending between the proximal end and the distal end so that a fluid barrier is created between the cylindrical end of the endoscope and the inner wall. | 2015-03-26 |
20150087908 | ENDOSCOPE SHEATH ARM - An endoscope sheath comprising: (a) a tube configured to receive all or a portion of a shaft of an endoscope, the endoscope including a light post in a proximal end region of the endoscope; and (b) an arm attached to and extending from a proximal end region of the sheath; wherein the arm has one or more features that are in communication with the light post to orient the sheath axially and rotationally with respect to the endoscope. | 2015-03-26 |
20150087909 | ENDOSCOPE SYSTEM INCLUDING A RESILIENT RESERVOIR - A system comprising: (a) a sheath configured to receive all or a portion of an endoscope; (b) an irrigation line connecting the sheath to an irrigation source; (c) a suction line connecting the sheath to a suction source; and (d) a control module located between the sheath, and the irrigation source and the suction source and controls flow of irrigation fluid from the irrigation source to the sheath and movement of suction between the suction source and the sheath; wherein the irrigation source is connected to a resilient reservoir that is located within the control module and movement of the control module compresses the resilient reservoir moving irrigation fluid from the resilient reservoir to the sheath so that the irrigation fluid assists in cleaning the endoscope, and wherein the control module includes a valve and compression of the resilient reservoir initiates movement of the valve so that the valve opens and suction from the suction line is applied to the sheath. | 2015-03-26 |
20150087910 | ENDOSCOPE - An endoscope includes an insertion portion, a first bending portion, a second bending portion, a bending operation wire, a first coil sheath, a switching mechanism, a guide, a first region of the guide, a second region of the guide, and a central part formed between the first region and the second region on an inner surface of the guide, protruding inside more than the first region and the second region and formed to be longer than a coil elemental wire making up the first coil sheath. | 2015-03-26 |
20150087911 | ENDOSCOPE SHEATH DEFLECTION DEVICES - An endoscope sheath comprising: a tube having: a proximal end having a proximal end region and a distal end; and a conduit that extends through a portion of the endoscope sheath so that the proximal end region of the endoscope sheath and the distal end of the endoscope sheath are in fluid communication when an endoscope is inserted inside the endoscope sheath; and wherein the endoscope sheath is configured to receive all or a portion of the endoscope; wherein the distal end of the endoscope sheath has a flow director configured to direct irrigation fluid across a lens on the distal end of the endoscope; and wherein the flow director is a flexible flap. | 2015-03-26 |
20150087912 | Endoscope - An endoscope includes a window component made of a transparent material at the distal end of the endoscope, wherein the window component is not rotationally symmetric in relation to the direction of view, and an optical correction apparatus for correcting the aberration of the window component. | 2015-03-26 |
20150087913 | NATURAL ORIFICE ACCESS DEVICE - Embodiments of a natural orifice access device that is adapted for being coupled to a cap and that may be adjusted in length to accommodate variations in patient body types and variations in the location of surgical sites within the natural orifices of patients are described. | 2015-03-26 |
20150087914 | SURGICAL IMPLEMENT GUIDE ASSEMBLY AND METHODS - Features of guides and surgical implements, which may be utilized together in various assemblies, are disclosed. Surgical implements or other devices within the scope of this disclosure may include a circumferentially grooved knob. The knob may be configured to receive a portion of a guide. Further, a clip may be configured to releasably secure the guide to the surgical implement. The clip may be coupled to the knob, for example, by a strap rotatably coupled to the knob. The knob may also define a stop-ledge configured as an abutment for the guide. The knob may also define a central passageway, which may also be surrounded by a hollow hub, for receiving an additional surgical implement or device. | 2015-03-26 |