13th week of 2014 patent applcation highlights part 52 |
Patent application number | Title | Published |
20140087915 | FRICTION-RING TRANSMISSION HAVING TWO ROLLER BODIES SPACED APART FROM ONE ANOTHER BY A GAP - A friction ring-type transmission includes two roller bodies which are arranged at a distance from each other about a gap, which correspond to each other via the friction ring and which rotate ( | 2014-03-27 |
20140087916 | HYDRAULIC REGENERATION APPARATUS - A hydraulic motor/pump regenerator system for recovering energy from the moving vehicle having high efficiency and precise control, thereby allowing the maximum amount of energy to be recovered and reused, is described. Three, fixed-displacement pump/motors are used to enable the system to recover and reapply energy at efficiencies expected to be above 70% in most circumstances. The invention is not limited to the use of three fixed displacement hydraulic units since using more units may in some drive cycles further improve efficiency. By selecting an appropriate combination of pump/motor units for providing the driveshaft torque required by the driver, embodiments of the present invention generate high recovery efficiency at any speed. | 2014-03-27 |
20140087917 | VEHICLE AND CONTROL METHOD FOR VEHICLE - A vehicle includes an accelerator pedal, a drive device and an electronic control unit (ECU). The drive device generates driving force for driving a wheel on the basis of an operation amount of the accelerator pedal. The ECU, while the vehicle is travelling in a ready-off state, prohibits a shift into a ready-on state until the operation amount of the accelerator pedal once becomes lower than a predetermined value. | 2014-03-27 |
20140087918 | METHOD OF CONTROLLING CLUTCH OF VEHICLE - A method controls a clutch for vehicles. In a vehicle provided with a transmission such as a DCT or AMT which uses a dry clutch as a launch clutch, the clutch is controlled such that clutch control torque can smoothly vary when a driver manipulates an accelerator pedal during creep driving under a control logic so that the controlling of the clutch is converted into launch control, thus preventing the vehicle from jerking and improving the ride comfort of the vehicle, thereby enhancing the merchantability of the vehicle. | 2014-03-27 |
20140087919 | FORM ASSEMBLY FOR A JUMP PIT - A form assembly and method is provided for use in making a jump pit having a cover. The form assembly comprises at least one frame member structured to form a ledge for receiving the cover and a removable form member removably secured to the frame member. The method comprises providing a frame member and removably securing a removable form member to the frame member. | 2014-03-27 |
20140087920 | Foldable Parallel Bar Apparatus - A foldable parallel bar apparatus includes generally U-shaped first and second end frames and a set of handrails connected to and extending between the first and second end frames, wherein the handrails are foldable so as to move the first and second end frames closer to one another thereby compacting the apparatus. When multiple modules of the end frames are connected, they provide an uninterrupted path between the handrails. An alternative embodiment provides base platforms that are foldable relative to each other and handrails that are vertically and horizontally adjustable. | 2014-03-27 |
20140087921 | Device for Cooperative Hand Function Trainings in Rehabilitation and Corresponding Method - The invention is directed to a device to train bilateral, cooperative hand functions of a subject with housing means, handle means comprising two exchangeable handles ( | 2014-03-27 |
20140087922 | TREADMILL WITH INTEGRATED WALKING REHABILITATION DEVICE - A treadmill for providing walking rehabilitation to a rehabilitee is provided. The treadmill includes a base including a belt, a motor interconnected with the belt, and a walking rehabilitation device interconnected with the base. The motor causes the belt to rotate in a first direction. The walking rehabilitation device includes a user engagement structure configured to be removably secured to one or more locations of a rehabilitee's extremities. The walking rehabilitation device further includes a transmission interconnecting the motor and the user engagement structure, the transmission transferring motion from the motor to the rehabilitee via the user engagement structure, allowing the rehabilitee to walk along the belt. | 2014-03-27 |
20140087923 | EXERCISE DEVICE - A user mountable stationary exercise device comprising, a base and a frame pivotally supported by the base such that the frame can pivot relative to the base about a pivot axis. The device also comprises a user actuated pedal arrangement supported by the frame and operatively connected to drive a wheel. In use, a user may mount the frame and apply force to the pedal arrangement to drive the wheel, and/or the frame to cause the frame to pivot relative to the base about the pivot axis. | 2014-03-27 |
20140087924 | Method and Apparatus For Cycling Training - A method and apparatus are provided for facilitating single-leg cycling training. The apparatus comprises a pair of legs connected to form a self-supporting structure that can be variably positioned relative to the rotational path of the pedals of a cycling device. One of the legs comprises a foot support configured to cooperate with a binding of a cycling shoe to support the foot while the other foot of the user is engaged with a pedal to perform single-leg training. The foot support comprises a pair of spaced apart rows of sockets configured to support the ends of a support rod. During use, the user places a foot on the support rod. | 2014-03-27 |
20140087925 | EXERCISE DEVICE - A multi-use exercise device includes a shaft extending between ground-engaging support structures with a pair of arms rotatable around the shaft into a plurality of various angular positions relative to the ground providing a plurality of different exercises with a plurality of different levels of difficulty. The exercise device can be used as a support structure for pushup and planking exercises, as well as shoulder mounted weight support for squats and lunges. | 2014-03-27 |
20140087926 | MUSCLE TRAINING AND EXERCISE APPARATUS AND METHOD FOR PLAYERS - An athletic training apparatus to assist a coach training muscle coordination of a player. An adjustable, delayed resistance, burst release, extension coil operatively couples to a first cable harness and a second cable harness. The first cable harness detachably couples to a coach and feedbacks real-time physical movements of the coach to the player. The second cable harness detachably couples to a training muscle group of the player. The training muscle group receives feedback from the real-time physical movements of the coach including a first resistance level during one portion of the exercise routine and a second resistance level during a second portion of an exercise routine. During an exercise routine, movements of the player are substantially unaffected and unstrained by the athletic training apparatus. | 2014-03-27 |
20140087927 | Balance Board Exercise Apparatus - A fitness apparatus for exercising with stretchable and resilient resistance bands includes a body member having a base and a rocker portion extending away from the base, the rocker portion having a generally convex configuration. The fitness apparatus includes a lid member having a generally planar configuration removably coupled to the body member. The lid member defines a pair of oppositely disposed lid member channels configured to receive the resistance bands therethrough for repositionable use in exercise by a user. | 2014-03-27 |
20140087928 | Body Weight Trainer and Methods of Using the Same - A body weight trainer fitness device allows for the strengthening and normalization of functional movement patterns for those who are not otherwise able. The device accomplishes this with the use of resilient strength bands which are provided in the form of heavy duty rubber bands of varying widths. The bands are selectively attached to a frame via selectively-moveable band holders. The device may then be used to offload the user's weight and thus decrease resistance or it can be used to increase the resistance of an exercise. The bands can be oriented to offload the user's body weight allowing a user to exercise with proper form. Once normal functional movement can take place without the bands, the device may be configured to utilize the bands as resistance to improve these functional motion patterns. | 2014-03-27 |
20140087929 | MOTION MUSCLE RELAXER - An exercise apparatus is provided to support the user in a bent-leg position and thereby guide the user through a series of swiveling, pitching, and rolling motions to stretch and align the user's back and spine. In one embodiment, the exercise assembly includes a base member, a leg support member for supporting a user's legs, and a vertical support member having a first end and a second end opposite the first end, the first end connected to the leg support member and the second end movably connected to the base member. In one embodiment, the leg support member includes a generally W-shaped undulated profile having a peaked portion and two recessed portions extending outward from opposite sides of the peaked portion. In another embodiment, the apparatus includes a ball joint connected to the second end of the vertical support, and swivelably, pitchedly, and rolledly connected to the base support member. | 2014-03-27 |
20140087930 | Therapeutic Platform - The present invention relates to a therapeutic platform that can be used to strengthen the core and secondary muscle groups via a variety of exercises which incorporate or centrally use the platform, while also providing a portable, lightweight and convenient platform, which includes storage for items used or associated with exercises incorporating the platform. | 2014-03-27 |
20140087931 | Waist and hip developer - A waist and hip developer includes a track curving smoothly upwardly toward two distal ends thereof and having two stop members respectively located at two distal ends thereof, foot members affixed to the track for supporting the track on the floor steadily, a slide slidably coupled to the track with rollers thereof and movable back and forth along the track between the stop members, a seat rotatably supported on the slide with a bearing within a predetermined angle and selectively lockable to the slide with a lock screw, a backrest hinged to the seat and lockable to the seat in an operative position by a lock screw, two grips respectively affixed to the two distal ends of the track, and a counter for counting of the number of reciprocating cycles of the slide moving by the user sitting on the seat. | 2014-03-27 |
20140087932 | PAPER FEED ROLLER - To provide a paper feed roller which hardly causes deterioration in the frictional coefficient due to paper powder accumulation and an accompanying paper conveyance failure, and can keep excellent paper feeding for a longer period. | 2014-03-27 |
20140087933 | METHOD FOR MANUFACTURING ABSORBENT ARTICLE - A method for manufacturing an absorbent article including a mounting step of conveying a web | 2014-03-27 |
20140087934 | LIQUID SWITCHING, DOSING AND PUMPING - A liquid handling device having an upstream liquid handling structure connected to a downstream liquid handling structure by a conduit. The upstream and downstream liquid handling structures are sealed or sealable such that the conduit provides the only fluidic communication paths between the upstream and downstream liquid handling structure. The device is arranged such that a driving force causes liquid in the upstream liquid handling structure to at least partially fill the conduit to separate gas in the upstream liquid handling structure from gas in the downstream liquid handling structure. With the device set up such that the two gas volumes are separated by a liquid volume, gas pressures and liquid flow in the device can be controlled by control of the driving force. The device may be arranged for rotation about an axis of rotation to provide the driving force. | 2014-03-27 |
20140087935 | GLASS PLATE FOR THIN FILM SOLAR CELL - A glass sheet for a thin-film solar cell of the present invention is characterized by including, as a glass composition in terms of mass %, 45 to 60% of SiO | 2014-03-27 |
20140087936 | CORE-SHELL PARTICLES WITH CATALYTIC ACTIVITY - The present invention pertains to novel core-shell particles comprising a core of iron oxide and a shell of cobalt oxide, characterized in that they are spherical with a number average diameter, as measured by TEM, of between 1 and 20 nm. This invention is also directed to their uses in the manufacture of a catalyst, and to the method for preparing these particles, by precipitating cobalt oxide onto magnetite or hematite particles which are themselves precipitated from Fe(III) and optionally Fe(II) salts. | 2014-03-27 |
20140087937 | Catalytic Article for Decomposing Volatile Organic Compound and Method for Preparing the Same - A catalytic article for decomposition of a volatile organic compound includes a porous support body, a plurality of active centers formed on the support body and adapted for catalytic decomposition of the volatile organic compound, and a plurality of capture centers bound to the support body. Each of the active centers is composed of one of a noble metal, a transition metal oxide, and the combination thereof. Each of the capture centers includes at least one functional group that is adapted for attracting or binding the volatile organic compound. A method for preparing the catalytic article is also disclosed. | 2014-03-27 |
20140087938 | SAND BED DOWNDRAFT FURNACE AND ACTIVATED CARBON SCRUBBER - A device for roasting spent activated carbon, waste sludges, or other organic wastes, includes a downdraft bed furnace, a first adsorber fluidly coupled to the furnace including a closed tank of adsorber process solution, a venturi scrubber and a cyclone separator coupled to the tank such that gases are sucked through the venturi and the cyclone separator, liquid effluents from the scrubber and separator falling by gravity into the tank, a second adsorber fluidly coupled to the first adsorber including a closed tank of adsorber liquid, a venturi scrubber and a cyclone separator coupled to the tank such that gases are sucked through the venturi and the cyclone separator, liquid effluents from the scrubber and separator falling by gravity into the tank, the second adsorber configured to remove impurities not removed in the first adsorber; and an exhaust blower fluidly coupled to the second adsorber unit and configured to pull air into the furnace and through the first and second adsorbers. | 2014-03-27 |
20140087939 | Metal-Carbon Composite Supported Catalyst for Hydrogen Production Using Co-Evaporation and Method of Preparing the Same - A metal-carbon composite supported catalyst for hydrogen production using co-evaporation and a method of preparing the same, wherein the catalyst is configured such that a metal-carbon composite having a core-shell structure resulting from co-evaporation is supported on the surface of an oxide-based support coated with carbon, thereby maintaining superior durability without agglomeration even in a catalytic reaction at a high temperature. Because part or all of the surface of metal is covered with the carbon shell, even when the catalyst is applied under severe reaction conditions including high temperatures, long periods of time, acidic or alkaline states, etc., the metal particles do not agglomerate or are not detached, and do not corrode, thus exhibiting high performance and high durability. Therefore, inactivation of the catalyst or the generation of side reactions can be prevented, so that the catalyst can be efficiently utilized in hydrogen production. | 2014-03-27 |
20140087940 | MIXED OXIDE COMPOSITIONS AND PROCESS FOR PREPARING ISOOLEFINS - The present invention relates to mixed oxide compositions, to the use thereof as a catalyst for cleavage of alkyl tert-alkyl ethers or tertiary alcohols, and to a process for cleaving alkyl tert-alkyl ethers or tertiary alcohols to isoolefins and alcohol or water. | 2014-03-27 |
20140087941 | Fibers of Polymer-Wax Compositions - Disposable article that include fibers formed from compositions comprising thermoplastic polymers and waxes are disclosed, where the wax is dispersed throughout the thermoplastic polymer. | 2014-03-27 |
20140087942 | PROMOTION OF PLANT GROWTH USING COLLAGEN BASED GELATIN - Compositions and related methods for promoting plant growth using irreversibly denatured collagen-based gelatin are described. In one embodiment, a covered plant propagation source comprises a plant propagation source covered by a covering material, the covering material comprising irreversibly denatured collagen-based gelatin. Another embodiment is directed to promoting plant growth by contacting one or more plant propagation sources with irreversibly denatured collagen-based gelatin prior to or during germination of the one or more plant propagation sources. | 2014-03-27 |
20140087943 | Pesticidal Active Mixtures Comprising Isoxazoline Compounds I - The present invention relates to pesticidal mixtures comprising as active compounds
| 2014-03-27 |
20140087944 | COMPOSITIONS AND METHODS FOR ENHANCING PLANT GROWTH - Described herein are compositions comprising one or more gluconolactones for enhancing plant growth and methods for treating plants, plant parts, or soils with one or more gluconolactones for enhancing plant growth. | 2014-03-27 |
20140087945 | SUBSTITUTED 4-CYAN-3-(2,6-DIFLUOROPHENYL)-4-PHENYLBUTANOATES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF AS HERBICIDES AND PLANT GROWTH REGULATORS - Compounds of the formula (I) or salts thereof, | 2014-03-27 |
20140087946 | Selective Insecticides Based on Anthranilic Acid Diamides and Safeners - The present invention relates to the use of selective insecticidal compositions, characterized by an effective amount of an active compound combination comprising
| 2014-03-27 |
20140087947 | HERBICIDAL COMPOSITIONS - The present invention provides, inter alia, a herbicidal composition comprising: (i) a protoporphyrinogen oxidase inhibiting herbicide selected from the group consisting flumioxazin, sulfentrazone, butafenacil and a diphenyl ether selected from the group consisting of acifluorfen (including aciflurofen-sodium), fomesafen (including fomesafen-sodium), lactofen and oxyfluorfen; or an agronomically acceptable salt of said herbicide; and (ii) a safener of Formula (II) or an agronomically acceptable salt of said compound, wherein:—is selected from the group consisting of halogen, nitro, C | 2014-03-27 |
20140087948 | METHODS OF REDUCING PLANT STRESS - A method of regulating plant genes is provided. The method provides improved drought stress or salinity stress for plants. The method comprises treating a part of a plant or the locus thereof with a composition of matter, the composition of matter comprising an agriculturally acceptable mixture of compounds of natural organic material of defined composition. | 2014-03-27 |
20140087949 | SUBSTITUTED 5-(CYCLOHEX-2-EN-1-YL)-PENTA-2,4-DIENES AND 5-(CYCLOHEX-2-EN-1-YL)-PENT-2-EN-4-INES AS ACTIVE AGENTS AGAINST ABIOTIC STRESS IN PLANTS - The invention relates to substituted 5-(cyclohex-2-en-1-yl)penta-2,4-dienes and 5-(cyclohex-2-en-1-yl)pent-2-en-4-ines of the formula (I) and their salts | 2014-03-27 |
20140087950 | FAULT CURRENT LIMITER - Provided is a fault current limiter that uses a superconductor and can rapidly restore a superconducting state after a current limiting operation. The fault current limiter is configured to perform a current limiting operation through the use of a superconductor and includes a superconducting member (a member including a holding container, a filler and a superconducting wire) including the superconductor, a cooling container, and a suppression member (fins). The cooling container is configured to hold therein the superconducting member and house therein a coolant for cooling the superconducting member. The suppression member (fins) is configured to prevent a boiling state of the coolant from transiting from a nucleate boiling state to a film boiling state in the case where the coolant boils on a surface of the superconducting member (a surface of the holding container) due to a temperature rise of the superconductor during the current limiting operation. | 2014-03-27 |
20140087951 | OXIDE SUPERCONDUCTOR THIN FILM AND SUPERCONDUCTING FAULT CURRENT LIMITER - An oxide superconducting thin film includes a substrate, and an intermediate layer and a superconducting layer provided in this order on the substrate. The intermediate layer has an average thickness of from 10 nm to 20 nm and a surface roughness Ra of 0.5 nm or less. The superconducting layer is formed on a surface of the intermediate layer and includes an oxide superconductor as a main component. A superconducting fault current limiter including the oxide superconducting thin film is also provided. | 2014-03-27 |
20140087952 | Efficient Polarization Independent Single Photon Detector - A superconducting nanowire single photon detector (SN-SPD) microelectronic circuit is described which has higher quantum efficiency and signal-to-noise than any SN-SPD's known in the art. The material and configuration of the microelectronic circuit eliminates the polarization dependence and shows improved signal-to-noise over SN-SPD microelectronic circuits known in the art. The higher efficiency, polarization independence, and high signal-to-noise is achieved by vertically stacking two tungsten-silicide (TS) SN-SPDs and electrically connecting them in parallel. This structure forms a multilayer superconducting nanowire avalanche photo-detector (SNAP). A single photon detection device employing the multilayer (SNAP) microelectronic circuit demonstrates a peak system detection efficiency of 87.7% and a polarization dependence of less than 2%. This represents nearly an order of magnitude improvement in both system detection efficiency and reduction of polarization dependence compared to conventional SNSPDs. | 2014-03-27 |
20140087953 | Ultra-Light, Magnetically Shielded, High-Current, Compact Cyclotron - A cyclotron for ion acceleration is magnetically shielded during ion acceleration by passing electrical current in the same direction through both the first and second superconducting primary coils. A first magnetic-field-shielding coil is on the same side of the mid plane as the first superconducting primary coil, while a second magnetic-field-shielding coil is on the same side of the midplane as the second superconducting primary coil and beyond the outer radius of the second superconducting primary coil. Electrical current is also passed through the magnetic-field-shielding coils in a direction opposite to the direction in which electrical current is passed through the superconducting primary coils and generates a canceling magnetic field that reduces the magnetic field generated at radii from the central axis beyond the magnetic-field-shielding coils. | 2014-03-27 |
20140087954 | QUANTITATIVE NUCLEASE PROTECTION ASSAY (QNPA) AND SEQUENCING (QNPS) IMPROVEMENTS - The present disclosure provides an improvement to quantitative Nuclease Protection Assay (qNPA) and quantitative Nuclease Protection Sequencing (qNPS) methods. The disclosed methods use nuclease protection probes (NPPs) that include 5′-end and/or 3-end flanking sequences, which provide a universal hybridization and/or amplification sequence. The disclosed methods can be used to sequence or detect target nucleic acid molecules, such as those present in fixed or insoluble samples. | 2014-03-27 |
20140087955 | DEVICES AND METHODS FOR EFFICIENT CAPTURE OF NUCLEIC ACIDS - The present invention relates a device for the efficient binding of nucleic acids on a microarray, comprising a reaction zone comprising a microarray, and a capture zone comprising a porous membrane substrate, wherein the capture zone is capable of specifically capturing sense strands of target molecules, whereas complementary antisense strands are captured in the reaction zone, or vice versa. The invention further envisages temperature regulating units in the device allowing to bring or keep the capture at a temperature not allowing hybridizing or binding of nucleic acid(s) to the capture molecules or to a temperature suitable for nucleic acid hybridization. The invention also relates to a method of efficiently binding nucleic acids on a microarray, comprising introducing a medium containing one or more target molecules in denatured form into a capture zone of a device of the present invention, performing an interaction reaction between the target molecules and immobilized capture molecules in said capture zone, and transporting not bound target molecule strands to a reaction zone comprising a microarray, thereby allowing an interaction between the target molecule strands and immobilized capture molecules on the microarray. In a further aspect the invention relates to the use of such a device for enriching target molecules, specifically selecting a target molecules, expression analysis, comparative genomic hybridization, the detection of SNPs, or for microarray-based genomic selection-based sequencing. | 2014-03-27 |
20140087956 | NOVEL COMBINATION OF FLUORESCENT DYES FOR THE DETECTION OF NUCLEIC ACIDS - The present invention relates to combinations of fluorescent dyes used in molecular biology, particularly in multiplex PCR. In particular, the present invention relates to a combination of dyes for amplification reactions, wherein at least four different dyes are used, wherein the first dye is 5-FAM or 6-FAM or a blend thereof, the second dye is selected from the group consisting of DY-530, HEX, CAL Fluor Orange 560 and ATTO 532, the third dye is selected from the group consisting of ATTO 550, DY-555 and DY-556, the fourth dye is selected from the group consisting of ROX, DY-510XL and ATTO 565, and optionally a fifth dye is selected from the group consisting of DY 632 and DY-520XL. | 2014-03-27 |
20140087957 | METHODS, ASSAYS AND KITS FOR CANCER DIAGNOSIS AND SCREENING UTILIZING GLYCAN-BINDING AND GLYCAN EPITOPES - The invention relates to the diagnosis, monitoring, prognosis, and/or prediction of cancer utilizing the detection or measurement of glycan-protein interactions, particularly glycan-antibody interactions. The invention relates to carbohydrate-containing molecules that are utilized in bioanalytical systems, methods and kits for detecting neoplasia and methods related thereto and based thereon. In an exemplary embodiment glycans or glycopolymers are carried in an array, on beads or in a microfluidic system for diagnostic screening for risk of neoplasia, the existence of neoplasia in a patient, or for treatment monitoring. In such an embodiment, the bioanalytic system identifies binding interactions between molecules in a patient test sample (e.g., glycan compositions) and the glycans or glycopolymers. The glycan-binding compositions may be used to generate an immune response against cancer cell epitopes. Alternatively, antibody therapeutics can be developed that are useful for binding to glycan compositions on a cell surface. | 2014-03-27 |
20140087958 | HONEYCOMB TUBE - A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate. The well chamber is in fluidic communication between the pre-amplification chamber and the fluidic outlet. | 2014-03-27 |
20140087959 | Methods And Compositions Involving Intrinsic Genes - Disclosed are compositions and methods related intrinsic gene sets and methods and compositions related to detecting and classifying cancer. | 2014-03-27 |
20140087960 | Markers Related to Age-Related Macular Degeneration and Uses Therefor - Methods are provided of screening for age-related macular degeneration (AMD), including a risk of a subject devel - oping AMD or a risk of a subject progressing to an advanced fom of AMD. The methods can include analyzing a sample obtained from the subject for the presence of at least one single nucleotide polymorphism (SNP) selected from the group consisting of rs4711751, rs6982567, rs1999930, rs13278062, rs1912795, rs2270637, rs12040406, rs1367068, rs1079982, rs1443179, rs7720497, and/or rs6 1800454. | 2014-03-27 |
20140087961 | GENETIC VARIANTS USEFUL FOR RISK ASSESSMENT OF THYROID CANCER - The invention discloses genetic variants that have been determined to be susceptibility variants of thyroid cancer. Methods of disease management, including methods of determining susceptibility to thyroid cancer, methods of predicting response to therapy and methods of predicting prognosis of thyroid cancer using such variants are described. The invention further relates to kits useful in the methods of the invention. | 2014-03-27 |
20140087962 | Identification of Linkage Using Multiplex Digital PCR - This specification generally relates to methods of detecting the linkage between two or more targets in a sample using digital multiplex PCR. A method of identifying physical linkage between two or more nucleic acid targets in a sample is provided. The method includes diluting the sample via limiting dilution and aliquoting the diluted sample into wells. The method further includes performing multiplex PCR in each chamber, where a first dye is used for the first target and a second dye is used for the second target. The method includes identifying the presence of the first and second dyes in the wells, wherein a non-random distribution of the dyes identifies the targets as linked. | 2014-03-27 |
20140087963 | IMMUNOSIGNATURING: A PATH TO EARLY DIAGNOSIS AND HEALTH MONITORING - Health is a complex state that represents the continuously changing outcome of nearly all human activities and interactions. The invention provides efficient methods and arrays for health monitoring, diagnosis, treatment, and preventive care. The invention monitors a broad range of identifying molecules from a subject, such as circulating antibodies, and the invention evaluates a pattern of binding of those molecules to a peptide array. The characterization of the pattern of binding of such molecules to a peptide array with the methods of the invention provide a robust measure of a state of health of a subject. | 2014-03-27 |
20140087964 | COMPOSITIONS AND METHODS FOR DETECTING ABERRANT REGULATION, EXPRESSION, AND LEVELS OF HGH - Detection of human growth hormone use is very challenging due to the short half-life of circulating human growth hormone and the fact that the recombinant human growth hormone used is identical in protein sequence as the native, naturally produced growth hormone. The chief objective of this invention is to discover a marker(s) that will identify use of recombinant human growth hormone use. In the case of this invention, we have discovered specific circulating micro RNA (miRNA) that can be detected and quantified in plasma of individuals taking recombinant human growth hormone. | 2014-03-27 |
20140087965 | MARKER FOR DIAGNOSING DIABETIC RETINOPATHY AND USE THEREOF - The present invention relates to a marker which can be used to diagnose a diabetic retinopathy patient and determine the progression of diabetic retinopathy, a composition for diagnosing diabetic retinopathy, which comprises an agent for measuring the level of a gene or protein associated with the marker, and the use thereof. | 2014-03-27 |
20140087966 | Detection and Differentiation of Demodex Mites - Methods of detecting | 2014-03-27 |
20140087967 | METHODS AND COMPOSITIONS FOR DIAGNOSING COMPLICATIONS OF PREGNANCY - The present invention provides methods and compositions for identifying subjects at risk of developing a complication of pregnancy, such as preeclampsia or preterm labor. The compositions are microRNAs and associated nucleic acids. | 2014-03-27 |
20140087968 | MODIFIED RNASE H AND DETECTION OF NUCLEIC ACID AMPLIFICATION - A reversibly modified ‘hot start’ RNase H enzyme composition is described for the improved CATACLEAVE™ probe detection of nucleic acid sequences in a test sample. A key feature of the enzyme composition is the ability to regulate the catalytic activity of the RNase H during the course of a reverse transcription-PCR cycle. Thus, RNase H activity can be initially suppressed to minimize degradation of RNA:DNA primer heteroduplexes prior to reverse transcription. After cDNA synthesis is complete, RNase H activity is induced to promote the cleavage and fluorescent detection of CATACLEAVE™ probes that anneal to target DNA sequences within the reverse transcriptase-PCR products. The inducible RNase H enzyme is amenable to high throughput applications requiring one step reverse transcriptase CATACLEAVE™ PCR in a single reaction mix. | 2014-03-27 |
20140087969 | PIM-3 Kinase as a Target for Type 2 Diabetes Mellitus - The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus. | 2014-03-27 |
20140087970 | SERINE BIOSYNTHESIS PATHWAY INHIBITION FOR TREATMENT OF CANCER - In some aspects, the invention provides compounds and methods of use for treating tumors. In some aspects, the methods comprise administering a serine biosynthesis pathway inhibitor to a subject, wherein the subject has a tumor that overexpresses PHGDH In some embodiments, the tumor is an ER negative breast cancer. In some aspects, the invention provides an in vivo RNAi-based negative selection screen of use to identify drug targets for treatment of tumors. | 2014-03-27 |
20140087971 | MULTIPLEXED FLOW ASSAY BASED ON ABSORPTION-ENCODED MICRO BEADS - Analysis of a system and/or sample involves the use of absorption-encoded micro beads. Each type of micro bead is encoded with amounts of the k dyes in a proportional relationship that is different from proportional relationships of the k dyes of others of the n types of absorption-encoded micro beads. A system and/or a sample can be analyzed using information obtained from detecting the one or more types of absorption-encoded micro beads. | 2014-03-27 |
20140087972 | METHOD OF IMMOBILISING RNA ONTO A SURFACE - The invention relates to a method of immobilising at least one RNA molecule onto a surface of a support comprising: i) providing a first support having a surface on which at least one DNA molecule is immobilised, wherein the DNA molecule encodes an RNA molecule and the encoded RNA molecule comprises a binding molecule; ii) providing a second support having a surface on which at least one binding partner for interacting with the binding molecule is immobilised; iii) arranging the first and second supports such that the surfaces displaying the immobilised molecules are in close proximity and substantially face each other, and contacting the DNA molecule immobilised on the surface of the first support with transcription reagents; and iv) carrying out a transcription reaction to generate the encoded RNA molecule, wherein the RNA molecule is directly immobilised onto the surface of the second support via an interaction between the binding molecule of the RNA molecule and the binding partner on the surface of the second support. | 2014-03-27 |
20140087973 | INTEGRATED CARRIER FOR MICROFLUIDIC DEVICE - An injection molding method of fabricating a carrier for holding a microfluidic device can form all of the desired features of such a carrier, including wells, channels and ports having smaller dimensions and greater density than previously achieved, while reducing or avoiding fracturing and the need for drilling the substrate to form certain features, in particular the ports. The carrier includes a substrate with a plurality of wells, each well defining a volume of between 0.1 μl and 100 μl; a plurality of channels within the substrate wherein each well is in fluid communication with at least one of the plurality of channels; a plurality of ports within the carrier substrate wherein each port is for coupling with regions in the carrier substrate adapted to receive fluids or pressure; and a receiving portion for receiving a microfluidic device and placing the microfluidic device in fluid communication with the plurality of wells. The carrier has a polymeric composition and/or an array of structural features achieved via the injection molding fabrication technique that enhance its performance and compatibility with existing instrumentation. | 2014-03-27 |
20140087974 | Particulate Weighting Agents Comprising Removable Coatings and Methods of Using the Same - Additives used in treatment fluids include particulate weighting agents comprising removable coatings which can be used in methods such as drilling and cementing operations; a method includes providing a treatment fluid for use in a subterranean formation, the treatment fluid including a coated particulate weighting agent including a core weighting agent having a first specific gravity and a removable polymer coating having a second specific gravity, the first specific gravity and the second specific gravity are not the same, introducing the treatment fluid into the subterranean formation, and allowing a portion of the removable polymer coating to be removed to alter the specific gravity of the coated particulate weighting agent down hole. | 2014-03-27 |
20140087975 | TREATMENT FLUID CONTAINING A CORROSION INHIBITOR OF A POLYMER INCLUDING A SILICONE AND AMINE GROUP - A treatment fluid comprises: water; a carboxylate; and a corrosion inhibitor, wherein the corrosion inhibitor is a polymer, wherein the polymer comprises silicone, an ether monomer residue, and an amine functional group; wherein a test fluid consisting essentially of the water, the carboxylate, and the corrosion inhibitor, and in the same proportions as in the treatment fluid, is capable of providing a corrosion weight loss to a metal plate of less than 0.05 pounds per square feet (lb/ft | 2014-03-27 |
20140087976 | Method of Drilling Boreholes With Invert Emulsion Drilling Fluids Having Enhanced Rheology - An invert emulsion drilling fluid, and a method of drilling with such fluid, having improved rheology effected with addition of a fatty dimer diamine additive in the presence of little or no lime. The drilling fluids of the present invention exhibit similar yield points and gel strengths at temperatures ranging from about 40° F. to about 375° F. or higher and at pressures ranging from about 0 psi to about 13500 psi. | 2014-03-27 |
20140087977 | HIGH WATER AND BRINE SWELL ELASTOMERIC COMPOSITIONS AND METHOD FOR MAKING AND USING SAME - Swellable compositions including at least one curable elastomer, a least one cure system, at least one high molecular weight (HMW) swelling agent and at least one low molecular weight (LMW) swelling agent. Methods for making swellable compositions including at least one curable elastomer, a least one cure system, at least one high molecular weight (HMW) swelling agent and at least one low molecular weight (LMW) swelling agent. Methods for using swellable compositions including at least one curable elastomer, a least one cure system, at least one high molecular weight (HMW) swelling agent and at least one low molecular weight (LMW) swelling agent. | 2014-03-27 |
20140087978 | METHODS OF CONVERTING AN INACTIVE BIOCIDE INTO AN ACTIVE BIOCIDE USING A CHEMICAL REACTION - A method of converting an inactive biocide into an active biocide comprises: contacting the inactive biocide with an activating agent, wherein the activating agent is capable of chemically reacting with the inactive biocide; and causing or allowing a chemical reaction to take place between the inactive biocide and the activating agent, wherein the chemical reaction produces the active biocide. The methods can also include deactivating the active biocide via a chemical reaction between the active biocide and a deactivating agent. | 2014-03-27 |
20140087979 | INVERT EMULSION BASED COMPLETION AND DISPLACEMENT FLUID AND METHOD OF USE - A method of cleaning a wellbore prior to the production of oil or gas, wherein the wellbore has been drilled with an invert emulsion drilling mud that forms an invert emulsion filter cake is disclosed. The method may include circulating a breaker fluid into the wellbore, where the breaker fluid includes a non-oleaginous internal phase and an oleaginous external phase, where the non-oleaginous phase includes a water soluble polar organic solvent, a hydrolysable ester of a carboxylic acid, and a weighting agent, and the oleaginous external phase includes an oleaginous fluid and an emulsifier, and where the hydrolysable ester is selected so that upon hydrolysis an organic acid is released and the invert emulsion of the filter cake breaks. | 2014-03-27 |
20140087980 | LUBRICANT COMPOSITIONS - Lubricant composition formulations comprising at least one biodegradable plastic, such as polyhydroxyalkanoate and/or polybutylene succinate, and at least one lubricant, such as a vegetable oil. | 2014-03-27 |
20140087981 | PLUNGER WATER-SOLUBLE LUBRICANT FOR DIE-CASTING - A plunger water-soluble lubricant for die-casting includes a component (a) being one or more than one of compounds selected from the group consisting of a mineral oil, a synthetic hydrocarbon, a grease, and a fatty acid ester; a component (b) being one or more than one of compounds selected from the group consisting of an alkali metal salt of a higher fatty acid and an alkali metal salt of an aliphatic hydroxy acid; a component (c) being one or more than one of compounds selected from the group consisting of an alkali metal salt of a synthetic sulfonic acid and an alkali metal salt of a petroleum sulfonic acid; particulate silica; and water. This plunger water-soluble lubricant for die-casting has a low burnability (flammability), and exerts an excellent lubricating property without lowering the productivity and worsening the working environment. | 2014-03-27 |
20140087982 | MICROENCAPSULATION OF LUBRICANT ADDITIVES - Provided is a lubricating oil including a nonpolar lubricating oil base stock as a major component and microcapsules as a minor component. The microcapsules includes (i) a core containing a polar solvent and one or more polar lubricating oil additives having solubility in the polar solvent, and (ii) optionally a shell or membrane enclosing the core. The solubility of the polar lubricating oil additives in the nonpolar lubricating oil base stock is improved as compared to solubility achieved using a lubricating oil containing polar lubricating oil additives in a nonpolar lubricating oil base stock and not containing the microcapsules. A method of improving solubility of polar lubricating oil additives in a nonpolar lubricating oil base stock is also provided. The lubricating engine oils of this disclosure can be useful in automotive, marine, aviation, and industrial engine and machine components. | 2014-03-27 |
20140087983 | LUBRICANT AND FUEL DISPERSANTS AND METHODS OF PREPARATION THEREOF - This disclosure relates to a composition for use as an additive for fuels and lubricants including an amination product of an epoxidized vinyl terminated macromonomer (VTM) and an amino compound containing at least one —NH— group. The epoxidized VTM is reacted with the amino compound containing at least one —NH— group under amination conditions sufficient to give said composition. The epoxidized VTM is formed by reacting a VTM with an epoxidizing agent under epoxidation conditions sufficient to give an epoxidized VTM. An amination method for making a composition for use as an additive for fuels and lubricants. The method comprises reacting an epoxidized VTM with an amino compound containing at least one —NH— group under amination conditions sufficient to give the composition. The epoxidized VTM is formed by reacting a VTM with an epoxidizing agent under epoxidation conditions sufficient to give an epoxidized VTM. | 2014-03-27 |
20140087984 | SYNTHETIC LUBRICANT BASESTOCKS AND METHODS OF PREPARATION THEREOF - This disclosure relates to vinyl terminated macromer (VTM) based synthetic basestocks and their methods of preparation, lubricant compositions, methods of lubrication and products so lubricated. The VTM based synthetic basestocks useful for fuels and lubricants include oligomerization or polymerization products of one or more allylic vinyl terminated macromers (VTMs) having a molecular weight from 84 to 10080. The one or more allylic VTMs are oligomerized or polymerized in the presence of a catalyst under oligomerization or polymerization conditions sufficient to give the VTM based synthetic basestock. The catalyst can be a metallocene catalyst or an acid catalyst, e.g., Lewis acid. The one or more allylic vinyl terminated macromers (VTMs) can be one or more allylic vinyl terminated atactic polypropylene macromers (VTM aPP) having a molecular weight from 84 to 2250 and having a terminal allylic vinyl olefin content of at least 90%. | 2014-03-27 |
20140087985 | LUBRICANT AND FUEL DISPERSANTS AND METHODS OF PREPARATION THEREOF - This disclosure relates to a composition for use as an additive for fuels and lubricants including a reductive amination product of a vinyl terminated macromonomer (VTM) based aldehyde. Optionally aldehyde is reacted with the amino compound under condensation conditions sufficient to give an imine intermediate, and the imine intermediate is reacted under hydrogenation conditions sufficient to give the composition. The aldehyde is formed by reacting a VTM under hydroformylation conditions sufficient to form the aldehyde. A reductive amination method for making a composition for use as an additive for fuels and lubricants. The method includes reacting a VTM based aldehyde with an amino compound containing at least one —NH— group under condensation conditions sufficient to give an imine intermediate, and reacting the imine intermediate under hydrogenation conditions sufficient to give said composition. The aldehyde is formed by reacting a VTM under hydroformylation conditions sufficient to form the aldehyde. | 2014-03-27 |
20140087986 | HIGH VISCOSITY, FUNCTIONALIZED METALLOCENE POLYALPHAOLEFIN BASE STOCKS AND PROCESSES FOR PREPARING SAME - A process for producing a high viscosity functionalized metallocene polyalphaolefin (mPAO) fluid. The process includes providing a mPAO having a terminal double bond, said mPAO produced by the metallocene-catalyzed oligomerization or polymerization of an alpha-olefin feed; providing at least one of a substituted or unsubstituted alkyl thiol, aryl thiol, diphenylamine or naphthalene; and reacting, optionally in the presence of a catalyst or initiator, the mPAO having a terminal double bond with at least one of the substituted or unsubstituted alkyl thiol, aryl thiol, diphenylamine or naphthalene, under reaction conditions sufficient to produce the functionalized high viscosity mPAO fluid. The functionalized mPAO fluid has, as synthesized, a viscosity (Kv | 2014-03-27 |
20140087987 | Production of Vinyl Terminated Polyethylene - This invention relates to processes to produce polyethylene involving contacting ethylene with a metallocene catalyst system; wherein the catalyst system comprises: a stoichiometric activator; and a metallocene compound. The metallocene catalyst system is also disclosed. | 2014-03-27 |
20140087988 | SENSORY USE OF 6-CYCLOPENTYLIDENEHEXANE DERIVATIVES - The invention concerns the use of 6-cyclopentylidenehexane derivatives—6, cyclopentylidenehexan-1-ol and 6-cyclopentylidenehexanal—as sensory agents giving off a fragrance and/or a flavor of interest for a use in perfumery, in cosmetic, in parapharmacy, in detergent industry and in the food industry. | 2014-03-27 |
20140087989 | AQUEOUS HAIR CLEANING AGENT - Provided is an aqueous hair cleansing composition, including the following components (A) to (D) and water, in which the aqueous hair cleansing composition has a pH of from 2 to 5 when diluted 20-fold: (A) an anionic surfactant; (B) a cationized hydroxypropyl cellulose having a main chain derived from an anhydroglucose, and having a degree of substitution with cationized ethyleneoxy groups of from 0.01 to 2.9 and a degree of substitution with propyleneoxy groups of from 0.1 to 4.0; (C) an organic solvent selected from (C1) and (C2): (Cl) an aromatic alcohol; and (C2) a polypropylene glycol having a molecular weight of from 200 to 1,000; and (D) a hydroxy monocarboxylic acid or a dicarboxylic acid. | 2014-03-27 |
20140087990 | NOVEL CARBOXYLIC ACID ESTER COMPOUND AND METHOD FOR PRODUCING SAME, AND FRAGRANCE COMPOSITION - The present invention provides a novel carboxylic acid ester compound useful as a fragrance component or a material for a compound fragrance and a method for producing the same, and provides a fragrance composition including the carboxylic acid ester compound. The present invention also provides an acyl fluorides of a 2,4-dimethyl-bicyclo[2.2.2]octane compound and the esters thereof, useful as the raw materials (inclusive of the intermediates of organic synthesis), for example, for the medicines, agricultural chemicals, fragrances, functional resins, optical functional materials and electronic functional materials. The carboxylic acid ester compound of the present invention is a compound represented by the general formula (1). | 2014-03-27 |
20140087991 | PEPTIDE PRODRUGS - Provided herein are a novel class of oligopeptides and prodrugs that include amino acid sequences containing cleavage sites for fibroblast activation protein (FAP). Also provided herein are methods of treating FAP related disorders, including cancer. | 2014-03-27 |
20140087992 | BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS AND PRODRUGS THEREOF - Disclosed are compounds of Formula (I) and/or salts thereof: | 2014-03-27 |
20140087993 | PEPDUCIN DESIGN AND USE - Disclosed here is the rational design and use of potent and specific GPCR antagonist pepducins based on GPCR regions such as the third intracellular loop and adjacent regions. | 2014-03-27 |
20140087994 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY - Template-fixed β-hairpin peptidomimetics of the general formula | 2014-03-27 |
20140087995 | Polypeptides - The invention relates to polypeptides comprising an amino acid sequence which is an analogue of human amylin, pharmaceutical compositions comprising these polypeptides, and these polypeptides for use as medicaments. | 2014-03-27 |
20140087996 | PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF - The invention relates to a pharmaceutical composition according to the claim | 2014-03-27 |
20140087997 | ANTI-MICROBIAL PEPTIDES AND USES OF SAME - A method of treating a bacterial infection in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of a peptide being between 3 and 5 amino acids, wherein at least one amino acid of said 3 and 5 amino acids is selected from the group consisting of tryptophan, cysteine, proline and methionine. | 2014-03-27 |
20140087998 | USE OF PACAP FOR THE TREATMENT VIRAL INFECTIONS IN AQUATIC ORGANISMS - The present invention relates to the use of pituitary adenylate cyclase activating polypeptide (PACAP) in the treatment of viral diseases and infectious diseases caused by viruses in aquatic organisms. PACAP, alone or combined with an antiviral molecule, demonstrated its effectiveness by increasing the survival of fish or crustaceans infected by viruses when it was administered orally, by injection or by immersion baths. Furthermore, it was observed that treated organisms keep or increase its weight as compared to infected and non-treated organisms. PACAP or PACAP-containing combinations decreased the viral load in tissues and organs susceptible to viral infections as it was determined by RT-PCR. | 2014-03-27 |
20140087999 | CLINICAL PREDICTORS OF WEIGHT LOSS - Methods and compositions are generally provided for treating metabolic disorders, e.g., obesity. One aspect discloses methods and compositions for obtaining a biological sample from the subject, evaluating the sample for the presence or absence of a genetic indicator, wherein the genetic indicator is selected from a single nucleotide polymorphism and a level of gene expression, and performing a first metabolic procedure if the genetic indicator is present, or performing an alternative second metabolic procedure if the genetic indicator is absent. One aspect discloses methods and compositions for obtaining a sample including deoxyribonucleic acids (DNA) from the subject, evaluating the DNA for an absence or presence of one or more genetic indicators and performing a first metabolic procedure or an alternative second metabolic procedure based on the absence or presence of the genetic indicator(s). Other aspects are also disclosed. | 2014-03-27 |
20140088000 | Leptin Rescues Neurons from Alzheimer's Disease Related Pathways Triggered by Lipid Burden - The described invention relates to compositions and methods for rescuing neurons from Alzheimer's Disease related pathways triggered by lipid burden or metabolic insult. | 2014-03-27 |
20140088001 | METHODS FOR DIAGNOSING ORGAN SPECIFICITY OF GLUCOSE INTOLERANCE - The present application pertains to a technique useful for the differentiation and diagnosis of organ specificity of hyperglycemia and glucose intolerance in type 2 diabetes, pre-diabetes or populations with risk to develop type 2 diabetes. | 2014-03-27 |
20140088002 | COMPOSITIONS AND METHODS FOR TREATMENT OF DIABETES - The present invention relates to compositions and methods for treatment and/or prevention of diabetes or pre-diabetes. In particular, the invention provides compositions and methods for the treatment and/or prevention of diabetes or pre-diabetes, based on the use of angiotensin-(1-7) peptides, functional equivalents thereof, and/or angiotensin (1-7) agonists. | 2014-03-27 |
20140088003 | POLYMER-BASED SUSTAINED RELEASE DEVICE - This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar. | 2014-03-27 |
20140088004 | Hepatocyte Growth Factor Mimics as Therapeutic Agents - Small molecule, peptidic hepatocyte growth factors mimics, which act as both mimetics and antagonists, have been generated. These molecules have been shown or predicted to have therapeutic potential for numerous pathologies including dementia, neurodegenerative disease, diabetes and metabolic syndrome, cancer, and defective wound healing. | 2014-03-27 |
20140088005 | DOUBLE-ACYLATED GLP-1 DERIVATIVES - The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 27 of GLP-1(7-37) (SEQ ID NO: 1); a second K residue at a position corresponding to position T of GLP-1(7-37), where T is an integer in the range of 7-37 except 18 and 27; and a maximum of ten amino acid changes as compared to GLP-1(7-37); wherein the first K residue is designated K | 2014-03-27 |
20140088006 | Stem Cell Mobilization and Tissue Repair and Regeneration - Stem cells are mobilized from bone marrow by administering an amount of Phe-Pro-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gin-Val (SEQ ID NO: 1) effective to mobilize the stem cells. This method is useful for promoting preservation, repair, or regeneration of bodily tissue, or revascularization, in a patient in need of such treatment. Alternatively, the mobilized stem cells can be collected for transplant. | 2014-03-27 |
20140088007 | COMPOSITION FOR THE ATTACHMENT OF IMPLANTS TO COLLAGEN OR OTHER COMPONENTS OF BIOLOGICAL TISSUE - The present invention relates to a novel composition comprising an implant, scaffold or construct bound to a biological or chemical moiety. The bound moiety has the ability to bind to a component of the extracellular matrix of biological tissue, allowing the implant to be bound to the biological tissue in a short period of time after implantation. The invention also relates to the use and manufacture of this novel composition, as well as a novel use for the protein CNA. | 2014-03-27 |
20140088008 | NOVEL ACTIVIN RECEPTOR AND USES THEREOF - The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides. Compositions and methods for treating muscle-wasting, metabolic and other disorders are also provided. | 2014-03-27 |
20140088009 | CHIMERIC NEUREGULINS AND METHOD OF MAKING AND USE THEREOF - Composition containing a chimeric neuregulin polypeptides and method of making such polypeptides are disclosed. The chimeric neuregulin comprises a first moiety of at least 10 amino acids, wherein the first moiety is derived from a first polypeptide; and a second moiety of at least 5 amino acids, wherein the second moiety is derived from a second polypeptide; wherein the first polypeptide is a neuregulin and the chimeric neuregulin exhibits an enhanced binding affinity to integrin, Erb 3, or Erb 4 comparing to that of the first neuregulin. | 2014-03-27 |
20140088010 | PHARMACEUTICAL PREPARATION - Preparations including poly (ethylene glycol) modified recombinant hCG(rhCG). | 2014-03-27 |
20140088011 | Softgel of NLKJ for treating prostate diseases - A softgel of NLKJ for the treatment of prostate diseases, comprising 0.05-1.0 g of NLKJ and 0.05-1.5 mg of an antioxidant, said NLKJ having the following physicochemical parameter: acid value<0.56, iodine value 95.0-107.00, saponification value 185.00-195.00, specific gravity 0.914-0.918 (20° C.), and refractive index 1.470-1.475 (20° C.). The inhibition of the softgel of NLKJ on the growth of prostate cancer in combination with the injection of Lupron is stronger than that of each of them used alone. | 2014-03-27 |
20140088012 | GENOMIC MARKERS FOR PREDICTION OF LONG-TERM RESPONSE TO 2 YEARS OF GROWTH HORMONE (GH) THERAPY - The present invention relates to the use of genetic markers to identify the response to growth hormone treatment in Growth Hormone Deficiency (GHD) or Turner Syndrome (TS) patients as well as a method of treating GHD or TS patients and kits for genotyping. | 2014-03-27 |
20140088013 | Complexation of Metal Ions with Polypeptides - Formulations and methods are provided for improving the stability upon exposure to aqueous media of polypeptides present in non-aqueous suspension vehicles. In particular aspects of the invention, formulations are provided that comprise a complex of a metal ion and a polypeptide suspended in a non-aqueous, biocompatible suspension vehicle. Aggregation of individual polypeptide molecules is reduced when aqueous media is introduced to such formulations, serving to stabilize the polypeptide. | 2014-03-27 |
20140088014 | FREEZE-DRIED PREPARATION CONTAINING HIGH-PURITY PTH AND METHOD FOR PRODUCING SAME - [Problem] Provided is a freeze-dried preparation containing high-purity PTH peptide and a method for the production thereof. Also provided is a test method for PTH analogs to confirm the purity of a freeze-dried preparation containing PTH peptide, and the like. | 2014-03-27 |