14th week of 2014 patent applcation highlights part 38 |
Patent application number | Title | Published |
20140093844 | METHOD FOR IDENTIFICATION OF FOOD INGREDIENTS IN MULTIMEDIA CONTENT - A method for identifying nutritional data related to food substances contained in a multimedia content item is provided. The method includes analyzing a received multimedia content item to identify multimedia elements containing food substance; generating at least one signature for each identified multimedia element; querying a deep-content-classification (DCC) system for each of the identified multimedia elements to find at least one concept that matches at least one of the identified multimedia elements; matching the at least one signature of each of the at least one matching concepts to previously generated signatures of food substances maintained in a data warehouse; retrieving, for each of the at least one matching signature, nutritional data associated with the at least one matching signature from the data warehouse, thereby providing nutritional data for the food substances substance contained in the received multimedia content item; and sending the nutritional data to the user device. | 2014-04-03 |
20140093845 | EXAMPLE-BASED ERROR DETECTION SYSTEM FOR AUTOMATIC EVALUATION OF WRITING, METHOD FOR SAME, AND ERROR DETECTION APPARATUS FOR SAME - An error detection system for automatically evaluating writing includes: an example construction apparatus to collect example sentences including various literary styles, to break up the collected example sentences in units of morphemes, and to construct the example sentences in an example-based index database (DB); and an error detection apparatus to break up an input sentence in units of morphemes, to generate one or more morpheme sequences bound in arbitrary window sizes based on one or more of morphemes of the broken-up input sentence, to search the example-based index DB for each of the generated morpheme sequences, and to detect an error according to a frequency at which said each morpheme is arranged in a corresponding morpheme sequence among morpheme sequences searched for through the example-based index DB. | 2014-04-03 |
20140093846 | LEARNING WORD GAME AND METHOD OF INSTRUCTION - A system and method for providing an educational grade-level based word game that incorporates kinesthetic, tactile, and auditory learning styles for use in teaching children and other learners how to spell in an entertaining manner. The game correlates grade appropriate words to the common core language arts standards. The game may be portable and uses direct social interaction between real people. The game can incorporate a foreign language as well as sign language. The physical game set may include, but is not limited to, playing cards, one regular numbered game die, one six-sided graphical cube, and a kinesthetic implement, such as an elastic rope or a bouncy ball. | 2014-04-03 |
20140093847 | AUTOMATED TEACHING SYSTEM USING DECLARATIVE PROBLEM SOLVING APPROACH - A system for solving problems in mathematics, natural science, engineering and like disciplines, online or on a computing device. The system includes an interface which employs a declarative approach to solution representation. The interface allows users such as students to enter their solutions by declaring main steps of a solution (in various modes and levels of detail). The interface provides a list from which a student selects an appropriate action and fills out the details of the computations related to the action. The system helps students learn the process of solving problems by teaching them how to divide solutions into logical steps. | 2014-04-03 |
20140093848 | METHOD AND APPARATUS FOR DETERMINING THE ATTENTIONAL FOCUS OF INDIVIDUALS WITHIN A GROUP - A method, apparatus and computer program product are provided to effectively determine the attentional focus of each of a plurality of individuals, such as the members of a group. In the context of a method, information is received identifying an attentional focus of each of a plurality of individuals. The method also includes determining, with a processor, a relationship between a threshold and a number of individuals with an attentional focus having a predefined association with a location. Further, the method includes causing an action to be performed based upon the relationship. | 2014-04-03 |
20140093849 | APPARATUS AND METHOD FOR LEARNING EMOTION OF ROBOT - An apparatus for the learning emotion of a robot includes an internal state calculation unit for detecting external environment information and calculating an internal state vector value for one point of an internal state coordinate system; an emotion decision processing unit for generating an emotion value within each emotion value group, indicated by the coordinates of the internal state input value of the robot on the coordinate system, as an emotion of the robot; a behavior generation unit for deciding the behavior of the robot based on the decided motion value and making an emotional expression; and an emotion learning unit for generating feedback information on the emotion value, corresponding to one point of the coordinate system, based on the decided emotion value and information on the type of emotion from a user input unit and changing an emotion probability distribution of the coordinate system using the feedback information. | 2014-04-03 |
20140093850 | Motivational Bracelet - A method for providing ongoing motivation to users who are attempting completion of a goal through the performance of individual steps. In the method, for each completed step towards a determined goal which is completed, the user is awarded a charm engageable to a bracelet. The ongoing positive reinforcement of the charms continues to motivate the user during all steps toward the goal. | 2014-04-03 |
20140093851 | HORSEBACK RIDING SIMULATOR AND METHOD FOR HORSEBACK RIDING SIMULATION - Disclosed is a horseback riding simulator configured to operate in an adaptive manner with respect to a user and a method using the same, the horseback riding simulator including a user identification unit to identify a user through user identification information based on user facial information extracted from an input image, a posture recognition unit to calculate user posture information by extracting information related to each of designated body parts of the user from the input image, a coaching unit to provide the user with instruction in horseback riding posture, based on the user identification information and the user posture information, and a sensory realization unit to control a horseback riding mechanism based on a user-intended posture calculated through analysis of the user posture information. Accordingly, user-customized horseback riding instruction is provided through identification of a user and recognition of a user's horseback riding posture. | 2014-04-03 |
20140093852 | SURGICAL TRAINING MODEL FOR LAPAROSCOPIC PROCEDURES - A model for practicing laparoscopic surgical skills is provided. The model includes a base having a plurality of practice stations at the upper surface. The practice stations include a cover having a first closed position in which a cavity is concealed beneath the cover and a second open position in which the cover is moved to uncover the cavity. The covers are connected to the surface in a number of ways to provide a variety of haptic responses useful in fine-tuning laparoscopic surgical skills. The cover is configured as a door hinged with or without a bias, a flexible flap, a sliding cover, a lid, and a penetrable sheet. An object for removal is hidden inside the cavity underneath the cover for practicing hand-to-hand transfer of instruments, use of both hands, switching instruments and determining and visualizing tissue planes in a laparoscopic environment. | 2014-04-03 |
20140093853 | CPR TRAINING SYSTEM AND METHODS - A system including a chest compression sensor configured to detect at least one parameter corresponding to chest compressions of a subject and an electrocardiogram signal simulator configured to generate a simulated electrocardiogram signal and combine and/or modify the simulated electrocardiogram signal with an output of the chest compression sensor to produce a simulated electrocardiogram signal with a CPR artifact. | 2014-04-03 |
20140093854 | SURGICAL TRAINING MODEL FOR TRANSLUMINAL LAPAROSCOPIC PROCEDURES - A model for practicing laparoscopic surgical skills is provided. The model comprises a body having an elongate lumen and a plurality of eyelets connected to an inner surface of the lumen. The plurality of eyelets defines at least one pathway for practicing the passing of at least one needle and suture through the eyelets. The model further includes a staging area with removable objects having apertures configured to be placed onto hook-like eyelets. The model provides a platform for practicing hand-to-hand transfer, depth perception among other skills required in laparoscopic procedures within a confined tubular space. The model may be placed inside a laparoscopic trainer in which the practice is performed in a simulated laparoscopic environment and observed on a video display. | 2014-04-03 |
20140093855 | SYSTEMS AND METHODS FOR TREATMENT OF LEARNING DISABILITIES - Methods, systems, apparatus, and non-transitory computer readable media for treating a user having a learning disability. In embodiments, the method comprises displaying, at a physical location on a display device, at least one graphic element associated with a virtual sound source position in a three dimensional soundfield corresponding to the physical position of the at least one graphic element, and responding to a user selection of one of the at least one graphic elements by playing a three dimensional audio effect having a perceived source located at the virtual sound source position corresponding to the selected graphic element. | 2014-04-03 |
20140093856 | SYSTEM AND METHOD FOR PROVIDING A USER WITH ADVISORY INFORMATION - According to embodiments, a method for providing a user with information includes storing one or more pieces of advisory information and identification information of each of the advisory information, recognizing a request for advisory information from the user, forming, on a sheet, the advisory information requested by the user, an image corresponding to the identification information of the requested advisory information, and an input region in which feedback from the user can be provided, scanning the image formed on the sheet and the input region in which the user has provided the feedback, and storing the feedback in association with the corresponding advisory information. | 2014-04-03 |
20140093857 | Method of Facilitating Online and Socially Networked Education Between Learning Institutions - A method is provided of facilitating online education between learning institutions, including the steps of obtaining an e-learning course from a content provider learning institution; obtaining the approval of a subscriber learning institution for students enrolled at such institution to receive academic credit for the successful completion of such e-learning course; enrolling students from such subscriber learning institution in such e-learning course through a website; providing such e-learning course to students of the subscriber learning institution; obtaining an evaluation of the students' performances in the e-learning course from the content provider learning institution; providing said evaluations of the students' performances in such e-learning course to the subscriber learning institution in which the students are enrolled; and providing remuneration to the subscriber learning institution and content provider learning institution. | 2014-04-03 |
20140093858 | METHOD AND SYSTEM FOR EVALUATING ELECTRONIC DOCUMENT - The disclosed embodiment relates to methods and systems for evaluating an electronic document. The computer implemented method includes receiving the electronic document containing a first set of answers corresponding to one or more pre-stored questions. The first set of answers are compared with a pre-stored second set of answers based on an answer descriptor syntax dataset. The answer descriptor syntax dataset comprises one or more rules. One or more answer descriptors for each of the first set of answers are determined based on the comparing. The one or more answer descriptors correspond to one or more observations for each of the first set of answers. Finally, the electronic document is evaluated based on determining. | 2014-04-03 |
20140093859 | Intelligence Crawling Pad - The invention is a crawling pad for the babies with a replaceable intelligence patch. The characteristic lies in: The crawling pad is divided into several areas based on different colorful design with allocated pockets by suture. The LED lamination and sound chips formed an intelligence patch can be inserted into individual pocket on the pad. The inserted intelligence patch comprises of: printed circuit board, LED lamination, sound chip and a controller with the automatic time-delay switch. All these components are set inside a fully heat-sealed patch that is formed: a printed decorative vinyl cover; then a soft lining on top of the electronic components; and the bottom is a clear/solid color vinyl. The bright patterns and sound enhance the cause and effect development to the babies at their early age. The variety choices of changeable patch with different patterns and sound empower the babies gaining new knowledge over time. | 2014-04-03 |
20140093860 | METHOD FOR ENHANCING MEMORY SKILLS - A system and method for assisting individuals in developing and refining memory skills is disclosed. The computer-base memory enhancing system provides users with a memory enhancing process, memory enhancing interface, memory enhancing files, and memory enhancing methods that provide users with tools to enhance memorization. Among the features and functionalities associated with the computer-base memory enhancing system are: (i) a memory enhancing method that suggests components from queries, (ii) a memory enhancing method that suggests component structures for arranging components, and (iii) a memory enhancing method that superposes components in real-world locations (“the augmented reality memory enhancing method”). | 2014-04-03 |
20140093861 | FOUR BAR DRIVE LINK SYSTEM SIMULATOR - This invention relates to a mechanical fixture which simulates a four bar link drive system for pedal driven scooters and bicycles and the resulting drive system. A four bar drive link system simulator has a frame assembly, a proximal hinge attachment bracket, a bottom bracket simulator | 2014-04-03 |
20140093862 | METHOD OF SIMULATING AN ENVIRONMENT - A method of simulating an environment has a back panel and at least one side panel. The method then selects a theme for the panels, selects a primary image for the back panel, and selects a related secondary image for the side panel. The primary and secondary images are asymmetric for upright installation. The primary image then identifies its front end and its back end and the secondary image does so also in this method. The method then aligns the front ends to the back ends. With the various ends aligned, the back panel is then installed upon a wall in a closet or a corner. With the back panel installed, the side panel is installed upon either the front end or the back end of the back panel. The side panel and the back panel create surroundings for a child to play in using his imagination to explore. | 2014-04-03 |
20140093863 | TRANSPARENT COOLING GEL - For cooling organs and tissues in transplantation medicine, only ice preparations are used so far which are not soft like a gel and are brought to the necessary degree of comminution by mechanically comminuting frozen, sterile, pyrogen-free isotonic infusion solutions, such as 5% glucose or 0.9% saline, with great effort. The lack of gel-like consistency of the preparations and the expensive production process are very disadvantageous. | 2014-04-03 |
20140093864 | INCREASING THE VIABILITY AND STRESS TOLERANCE OF VIABLE BIOLOGICAL MATERIAL - The present invention relates to a method for improving viability and/or stress tolerance of viable biological material and using the said material comprising applying hydrostatic pressure to said biological material; keeping the said viable biological material at the hydrostatic pressure for a predetermined time period; releasing the hydrostatic pressure; and using the said material for any desired purpose in accordance with any useful protocol. The usage of the said biological material incorporates any techniques, protocols that are applicable in the field of assisted reproductive techniques, biotechnical and/or biotechnological manipulations. | 2014-04-03 |
20140093865 | LATERAL FLOW ASSAYS FOR TAGGED ANALYTES - Methods of determining whether an analyte is present in a sample using a competitive assay are provided. Aspects of the methods include employing a competitor that provides for the obtainment of signal which is directly proportional to the amount of analyte in the sample. Also provided are devices and kits that find use in practicing the methods described herein. | 2014-04-03 |
20140093866 | FLUID MIXING AND DELIVERY IN MICROFLUIDIC SYSTEMS - The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user. | 2014-04-03 |
20140093867 | PARTICLE SEPARATION AND CONCENTRATION USING SPIRAL INERTIAL FILTRATION - A spiral inertial filtration device is capable of high-throughput (1 mL/min), high-purity particle separation while concentrating recovered target particles by more than an order of magnitude. Large fractions of sample fluid are removed from a microchannel without disruption of concentrated particle streams by taking advantage of particle focusing in inertial spiral microfluidics, which is achieved by balancing inertial lift forces and Dean drag forces. To enable the calculation of channel geometries in the device for specific concentration factors, an equivalent circuit model was developed and experimentally validated. Large particle concentration factors were achieved by maintaining either average fluid velocity or Dean number throughout the entire length of the channel during the incremental removal of sample fluid. Also provided is the ability to simultaneously separate more than one particle from the same sample. | 2014-04-03 |
20140093868 | CHROMATOGRAPHY METHOD - A chromatographic kit is provided including a labeling substance holding area having a labeling substance modified with a first binding substance of a test substance, and a labeling substance capturing area having a second binding substance of the test substance or a binding substance of the first binding substance in this order from upstream to downstream of a development direction of a test sample including the test substance, and further including an area having a color developing reagent in order to detect a first amplification reagent of two types of amplification reagents used to amplify the signal of the labeling substance when detecting the labeling substance. | 2014-04-03 |
20140093869 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS - This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto. | 2014-04-03 |
20140093870 | SINGLE MOLECULE IMAGING TECHNIQUES TO AID CRYSTALLIZATION - This invention relates to a method to rapidly find crystallization conditions for a biomolecule in a desired conformation using single-molecule, fluorescent resonance energy transfer (smFRET) imaging techniques. The method provides significant cost and time advantages over the empricial exploration for crystallization conditions. | 2014-04-03 |
20140093871 | Method for detecting mitochondria alterations - The present invention relates to a method for detecting mitochondria alterations, which comprises the following steps: (A) providing a separation element and a sample; (B) mixing the separation element and the sample, wherein a detecting sample is obtained through the binding of a DNA fragment on the separation element to mitochondrial DNA in the sample; (C) dividing the detecting sample into a comparison group and a detection group; (D) adding an amplification solution into the comparison group and the detection group respectively to begin a DNA amplified reaction, and further adding a restriction enzyme into the detection group, wherein the amplification solution comprises a labeling reagent and a primer pair; and (E) detecting amounts of the labeling reagent in the comparison group and the detection group respectively after the DNA amplified reaction. | 2014-04-03 |
20140093872 | Method of Mutation Detection in Blood Cell-Free DNA Using Primer Extension (PE) and PCR - A method of detecting mutation in blood cell-free DNA, includes providing a serum sample, isolating DNA from the serum sample, amplifying the DNA by polymerase chain reaction (PCR), subjecting the PCR product to primer extension (PE), and separating the PE reaction product and identifying the mutation by gel electrophoresis. In order to improve accuracy and sensitivity, the PE reaction can be carried out by using a primer that blocks the extension of the wild or non-mutated sequence. | 2014-04-03 |
20140093873 | PROCESSES AND COMPOSITIONS FOR METHYLATION-BASED ENRICHMENT OF FETAL NUCLEIC ACID FROM A MATERNAL SAMPLE USEFUL FOR NON-INVASIVE PRENATAL DIAGNOSES - Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies. | 2014-04-03 |
20140093874 | METHOD FOR DETECTING NUCLEIC ACID MOLECULE IN BIOSAMPLE - A method for detecting a nucleic acid molecule comprises: preparing a sample solution which contains a nucleic acid probe which is specifically hybridizable with the nucleic acid molecule to be analyzed, and a biosample; associating the nucleic acid molecule with the nucleic acid probe in the sample solution that has been prepared in the preparing; and after the associating, calculating, by the scanning molecule counting method, the number of molecules of the associated bodies including the nucleic acid probe in the sample solution that has been prepared in the preparing. This method for detecting a nucleic acid molecule further comprises: removing proteins from the sample solution before the calculating, or removing proteins from the biosample before the preparing. | 2014-04-03 |
20140093875 | MAMMALIAN CYTOKINES; RECEPTORS; RELATED REAGENTS AND METHODS - Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described. | 2014-04-03 |
20140093876 | MULTIPLEX NUCLEIC ACID DETECTION METHODS AND SYSTEMS - The present invention relates to methods and systems for single molecule based nucleic acid amplification and subsequent detection of nucleic acid molecules, and particularly to the determination of SNPs, mutations, and to the diagnosis of diseases associated with the changes of these nucleic acid molecules. | 2014-04-03 |
20140093877 | Cross priming amplification of target nucleic acids - The present invention relates to methods of amplification of nucleic acid sequences; more particularly, it relates to methods of amplifying target sequences by utilizing cross priming isothermal amplification. The present invention relates to methods of marking the amplification target sequence during the amplification reaction and rapid detection of the target sequence. The present invention also relates to reagent kits for rapid nucleic acid diagnosis and the nucleic acid detection of pathogenic microorganisms such as bacteria, viruses, as well as to diagnoses related to human genetic diseases. | 2014-04-03 |
20140093878 | MUTANT ENDONUCLEASE V ENZYMES AND APPLICATIONS THEREOF - Provided herein are mutant endonuclease V enzymes that are capable of nicking an inosine-containing DNA sequence. Nucleic acid assays and agents that employ such mutant endonuclease V enzymes to introduce a nick into a target DNA including one or more inosine, and uses a DNA polymerase to generate amplicons of a target DNA are also described. | 2014-04-03 |
20140093879 | Method and Apparatus for Generating Thermal Melting Curves in a Microfluidic Device - The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products. | 2014-04-03 |
20140093880 | COMPOSITIONS, KITS, AND METHODS FOR ISOLATING VESICLES - A composition, a kit, and a method of isolating a vesicle from a sample using a compound comprising zwitterion moieties, which may be used to analyze vesicles, and proteins, glycoprotein, lipids, or nucleic acids thereof. | 2014-04-03 |
20140093881 | Methods and Computer Program Products for Compression of Sequencing Data - A compression method includes: measuring a waveform associated with a chemical event occurring on a sensor array, wherein the waveform comprises a plurality of measured values and the chemical event is indicative of a number of nucleotide incorporations in a genetic sequencing reaction; applying a first compression process to the waveform, the first compression process including a truncating of data corresponding to a portion of the waveform that is not related to nucleotide incorporations in the genetic sequencing reaction; and applying a second compression process to the waveform, the second compression process including a data substitution process that replaces at least a portion of the waveform with a plurality of coefficients representative of the portion of the waveform. | 2014-04-03 |
20140093882 | METHODS OF DEPLETING A TARGET NUCLEIC ACID IN A SAMPLE AND KITS FOR PRACTICING THE SAME - Provided are methods of depleting a target nucleic acid in a sample. The methods include contacting a target nucleic acid with two or more polymers that specifically hybridize to the target nucleic acid, and cleaving the hybridized regions of the target nucleic acid to deplete the target nucleic acid in the sample. Kits for practicing the subject methods are also provided. | 2014-04-03 |
20140093883 | Nicking and Extension Amplification Reaction for the Exponential Amplification of Nucleic Acids - The invention is in general directed to the rapid exponential amplification of short DNA or RNA sequences at a constant temperature. | 2014-04-03 |
20140093884 | Process for Identifying Novel Anti-Inflammatory Molecules with Reduced Direct Transrepression of Genes Induced by Glucocorticoids - The present invention relates to a new process for identifying novel anti-inflammatory molecules with reduced direct transrepression of genes induced by glucocorticoids. | 2014-04-03 |
20140093885 | METHOD OF ANAEROBIC TISSUE-TARGETED GENE EXPRESSION INITIATED BY ALCOHOL DEHYDROGENASE PROMOTER AND THE APPLICATION THEREOF - A proteomic screening method for anaerobic-specific and expression-effective promoter, and a method of specially delivering and selectively stably expressing target gene in anaerobic tissue by an alcohol dehydrogenase promoter and uses thereof. The latter comprises an anaerobically-induced alcohol dehydrogenase promoter which is used as target gene promoter, anaerobic target bacteria and low copy number plasmid. Therefore, the target gene can be specially and highly expressed under hypoxia condition in vivo or in vitro. The selective gene expression which is driven by the alcohol dehydrogenase promoter in anaerobic tissue can be used as gene therapy method to treat anaerobic tissue disease including tumor, or to prepare anti-tumor drug. | 2014-04-03 |
20140093886 | Method of diagnosing cancer using a nucleolin specific aptamer - Improved G-rich oligonucleotide (GRO) aptamers specific to nucleolin, a method of preparing the aptamers, and a use of the aptamers for diagnosing and/or treating a nucleolin-associated disease, are provided. | 2014-04-03 |
20140093887 | PORPHYRINIC COMPOUNDS FOR USE IN FLOW CYTOMETRY - The present invention provides a method of detecting (e.g., by flow cytometry) a target compound, cell or particle, wherein the target is labelled with a detectable luminescent compound. The method comprises utilizing as the detectable luminescent compound a compound comprising a porphyrinic macrocycle such as a porphyrin, chlorin, bacteriochlorin, or isobacteriochlorin. In particular embodiments, the detectable luminescent compound comprises a compound of the formula A-A′-Z-B′-B, wherein: A is a targeting group or member of a specific binding pair that specifically binds the detectable luminescent compound to the target compound, cell or particle; A′ is a linker group or covalent bond; B′ is a linker group or covalent bond; B is a water-soluble group; and Z is the porphyrinic macrocycle. | 2014-04-03 |
20140093888 | HIGHLY PURE PLASMID DNA PREPARATIONS - The present disclosure generally relates to highly pure plasmid compositions having low, or undetectable, levels of colanic acid and other contaminants made by a process that includes the steps of obtaining a crude lysate of a plasmid DNA from a bacteria that makes colanic acid; treating the partially purified or purified plasmid DNA with a polypeptide that digests colanic acid under conditions that digest the colanic acid; and purifying the plasmid DNA from the digested colanic acid and the colanic acid degrading enzyme by one or more chromatography steps. | 2014-04-03 |
20140093889 | ANTI-NOTCH3 AGONIST ANTIBODIES AND THEIR USE IN THE TREATMENT OF NOTCH3-RELATED DISEASES - The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders. | 2014-04-03 |
20140093890 | QUANTITATIVE ASSAYS FOR RAS P21 IN BODY FLUIDS - The present invention is directed to the detection and quantification of total ras p21 in body fluids, particularly serial changes of total ras p21 levels in a subject's body fluids. Further, the invention is directed to detecting and quantitating total ras p21 in conjunction with one or more other proteins, such as, oncoproteins, angiogenic factors, tumor markers, inhibitors, growth factor receptors, metastasis proteins, and tumor suppressors. The disclosed methods are diagnostic/prognostic for preneoplastic/neoplastic diseases, and useful to select therapies for patients with preneoplastic/neoplastic diseases. The disclosed methods are further useful to monitor the status of a patient's preneoplastic/neoplastic disease, and/or to monitor how a patient is responding to an anticancer therapy. | 2014-04-03 |
20140093891 | DEVICE FOR PERFORMING A BIOCHEMICAL ANALYSIS, ESPECIALLY IN OUTER SPACE - A device for performing a biochemical analysis, especially in outer space, more particularly an immunoassay, in which analysis at least one analyte in a sample is determined selectively, having at least one reaction container which has at least one work volume which is intended for taking in a liquid volume and for performing at least one substep of an analysis reaction, and having at least one interface which is intended for connecting at least one work volume to a further media container. | 2014-04-03 |
20140093892 | MARKER COMPRISING ANTI-CK8/18 COMPLEX AUTOANTIBODY AND ITS USE FOR DIAGNOSING CANCER - The present invention relates to a cytokeratin 8/18 complex-specific autoantibody or a fragment comprising an antigen-binding site (paratope) thereof, the use thereof in the diagnosis of breast cancer, a polypeptide having an amino acid sequence of an epitope specifically binding to the autoantibody, a composition for diagnosing breast cancer comprising an agent capable of measuring an expression level of the autoantibody or the fragment comprising an antigen-binding site thereof, a hybridoma cell line producing the autoantibody, and a kit for diagnosing breast cancer comprising the composition of the present invention. Further, the present invention relates to a method for diagnosing breast cancer, comprising the step of detecting the cytokeratin 8/18 complex-specific autoantibody or the fragment comprising the antigen-binding site thereof using the composition of the present invention, and a method for screening a therapeutic agent for breast cancer using the autoantibody. | 2014-04-03 |
20140093893 | IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING METHOD - An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. | 2014-04-03 |
20140093894 | COMPOUNDS AND METHODS FOR ASSAYING REDOX STATE OF METABOLICALLY ACTIVE CELLS AND METHODS FOR MEASURING NAD(P)/NAD(P)H - The present invention provides compounds and methods for assaying redox state of metabolically active cells and methods for assaying enzyme activity and/or metabolite level by coupling to redox defining co-factor NAD(P)/NAD(P)H measurement. | 2014-04-03 |
20140093895 | SELF-CONTAINED TEST SENSOR - A test strip to assist in determining the concentration of an analyte in a fluid sample comprises a base, at least one tab and a break line. The base includes a capillary channel and a test element. The capillary channel is in fluid communication with the test element. The test element is adapted to receive the fluid sample. The at least one tab is removably attached to the base. The capillary channel extends from the base into a portion of the tab. The break line intersects the capillary channel in which an inlet to the capillary channel is exposed along the break line when the tab is separated from the base. | 2014-04-03 |
20140093896 | Point-Of-Care, Medical Condition Screening Kit - A point-of-care, screening kit for use by a heath care worker to create custom test strips for screening the bodily fluids of an individual for various, medical conditions includes: (a) a plurality of reagents ( | 2014-04-03 |
20140093897 | AROMATIC-CATIONIC PEPTIDES AND USES OF SAME - The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in electron transport and electrical conductance. | 2014-04-03 |
20140093898 | REDUCING INSOLUBLE DEPOSIT FORMATION IN ETHANOL PRODUCTION - The present inventors have surprisingly discovered that phytic acid tenaciously precipitates with soluble metals in food or fuel ethanol-processing fluid, producing insoluble organometallic salt deposit or scale on the processing equipment that must be removed in order to facilitate further ethanol processing. The present invention relates to converting phytic acid salts or phytates to inorganic phosphates to improve metal solubility and reduce deposition within processing equipment. | 2014-04-03 |
20140093899 | THYROGLOBULIN QUANTITATION BY MASS SPECTROSCOPY - Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample. | 2014-04-03 |
20140093900 | STEROID PROFILE IN OVARIAN FOLLICULAR FLUID FOR DIAGNOSIS, PROGNOSIS AND DETERMINING STRATEGIES FOR TREATMENT - Concentrations of endogenous steroids in ovarian follicular fluid are used to develop steroid profiles which provide means for the diagnosis and prognosis of endocrine-related conditions and for identifying and developing appropriate treatments for related conditions, including the identification and development of suitable protocols for in vitro fertilization (IVF), treatment and predictive strategies for successful IVF outcomes and selected uses of oocytes for IVF or embryonic stem cell procedures. | 2014-04-03 |
20140093901 | GENOME-SCALE METABOLIC NETWORK MODEL RECONSTRUCTION OF KLUYVEROMYCES MARXIANUS AND STRATEGIES FOR ENGINEERING NON-NATIVE PATHWAYS FOR 3-HYDROXYPROPIONATE PRODUCTION IN KLUYVEROMYCES MARXIANUS - Use of a metabolic network model for analyzing metabolic characteristics of microorganisms for producing a metabolic product, such as 3HP enabling estimation of productivity and cell growth speed of microorganisms, optimizing new metabolic pathway, and providing transformed microorganisms that may produce a specific metabolic product with high efficiency. | 2014-04-03 |
20140093902 | SILK TRANSISTOR DEVICES - The invention relates to ecosustainable and biocompatible, low cost, ambient friendly electronic and optoelectronic devices, such as transistors and light-emitting transistors, made with silk fibroin or blended with other biopolymers, methods for fabrication and methods of using the silk-based electronics and optoelectronics. The silk-based electronics and optoelectronics can be implanted in vivo and in vitro for biomedical applications, such as for drug discovery or drug screening assays and devices. The silk-based devices may be used in the food industry and embedded in packaging for tracking and sensing, for security purposes or exploited as disposable not harmful for the environment efficient general electronic and optoelectronic devices. | 2014-04-03 |
20140093903 | METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT - The invention provides methods, compositions, and systems for diagnosis, prognosis, evaluation of status, and/or determination of treatment for pathological conditions. | 2014-04-03 |
20140093904 | METHOD OF SINGULATING EMBRYOS - A method of sinuglating embryos is provided. The method includes providing a plurality of embryos ( | 2014-04-03 |
20140093905 | ORGAN MIMIC DEVICE WITH MICROCHANNELS AND METHODS OF USE AND MANUFACTURING THEREOF - System and method includes a body having a central microchannel separated by one or more porous membranes. The membranes are configured to divide the central microchannel into a two or more parallel central microchannels, wherein one or more first fluids are applied through the first central microchannel and one or more second fluids are applied through the second or more central microchannels. The surfaces of each porous membrane can be coated with cell adhesive molecules to support the attachment of cells and promote their organization into tissues on the upper and lower surface of the membrane. The pores may be large enough to only permit exchange of gases and small chemicals, or to permit migration and transchannel passage of large proteins and whole living cells. Fluid pressure, flow and channel geometry also may be varied to apply a desired mechanical force to one or both tissue layers. | 2014-04-03 |
20140093906 | ORGAN MIMIC DEVICE WITH MICROCHANNELS AND METHODS OF USE AND MANUFACTURING THEREOF - System and method includes a body having a central microchannel separated by one or more porous membranes. The membranes are configured to divide the central microchannel into a two or more parallel central microchannels, wherein one or more first fluids are applied through the first central microchannel and one or more second fluids are applied through the second or more central microchannels. The surfaces of each porous membrane can be coated with cell adhesive molecules to support the attachment of cells and promote their organization into tissues on the upper and lower surface of the membrane. The pores may be large enough to only permit exchange of gases and small chemicals, or to permit migration and transchannel passage of large proteins and whole living cells. Fluid pressure, flow and channel geometry also may be varied to apply a desired mechanical force to one or both tissue layers. | 2014-04-03 |
20140093907 | FLUORESCENT PROBES FOR MONITORING VOLTAGE BY PHOTO-INDUCED ELECTRON TRANSFER - Compounds and methods for determining transmembrane potential, monitoring changes in transmembrane potential, and/or drug screening are provided. In one aspect, compounds of the invention have a structure according to the formula: E-M-A, wherein A is a fluorophore, selected from xanthenes, eoumarins, cyanines, bimanes, and difluoroboradizaindacenes, charged at physiological pH; M is a molecular wire; and E is a hydrophobic moiety, wherein A and E are capable of being involved in a photo-induced, intramolecular electron transfer that quenches the fluorescence of A in response to a voltage condition. When in use, compounds of the invention are membrane-impermeant and oriented within the cell membrane such that the charged moiety localizes at the outer leaflet of the lipid bilayer and the hydrophobic moiety and molecular wire associate with the hydrophobic portion of the lipid bilayer. The rate of electron transfer, fluorescence intensity, and quenching are altered in response to changes in transmembrane potential. | 2014-04-03 |
20140093908 | SAMPLE PREPARATION APPARATUS AND SAMPLE PREPARATION METHOD - A sample preparation apparatus is provided. The apparatus comprises a first receiving part, a second receiving part, a filter part, a third receiving part, a flow path, a first moving means and a second moving means. The first receiving part is configured to accept a pipette and to receive a sample discharged from a pipette. The second receiving part is disposed at a position removed from the first receiving part in the plane of view. The filter part is configured to retain the cells to be analyzed within the second receiving part. The third receiving part is disposed opposite the second receiving part through the filter part The flow path is configured to connect the first receiving part and the second receiving part The first moving means is for moving a sample that has been received at the first receiving part to the filter part through the flow path and the second receiving part, and moving the components other than the cells to be analyzed to the third receiving part through the filter part. The second moving means is for moving the cells to be analyzed in the second receiving part from the second receiving part to the first receiving part. | 2014-04-03 |
20140093909 | POLYCATIONIC QUATERNARY AMMONIUM POLYMER COATINGS FOR IMMOBILIZING BIOLOGICAL SAMPLES - The present invention is directed to a pre-coated substrate, such as a slide, that is useful for immobilizing a sample. The invention is further provides methods of preparing such pre-coated substrates and methods of analyzing biological samples immobilized on such pre-coated substrate. The substrate is coated with a polycationic polymeric coating material specifically selected such that that coated substrate exhibits increased stability and prolonged shelf-life. Preferred polymeric coating materials include allylic or vinylic polymers having cationic groups thereon and having no more than a small percentage of peptidic monomeric linkages, particularly polydiallyldimethylammonium (PDDA). | 2014-04-03 |
20140093910 | D5 DESATURASE-DEFECTIVE MUTANT GENE AND USE THEREOF - It is an object of the present invention to provide a delta-5 desaturase-defective gene and uses of the gene and/or the mutant in algal transformation. | 2014-04-03 |
20140093911 | METHOD AND APPARATUS FOR IMAGE-BASED PREDICTION AND SORTING OF HIGH-PERFORMING CLONES - A method of predictive identification and separation of high-performing cells from a mixed population of cells includes distributing cells belonging to the mixed population to a plurality of open chambers; identifying open chambers containing desired cells and open chambers containing undesired cells; selectively sealing at least one open chamber containing undesired cells; and recovering the desired cells from the open chambers. Cells can be predictively assigned as desired or undesired based on an automated image analysis algorithm. | 2014-04-03 |
20140093912 | METHODS OF MAKING BIOACTIVE COLLAGEN MEDICAL SCAFFOLDS SUCH AS FOR WOUND CARE DRESSINGS, HERNIA REPAIR PROSTHETICS, AND SURGICAL INCISION CLOSURE MEMBERS - A method of preparing a crosslinked, collagen-based medical scaffold is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for wound care dressings, hernia repair prosthetics, and surgical incision closure members, prepared using the method above. | 2014-04-03 |
20140093913 | METHODS AND COMPOSITIONS FOR TREATMENT OF A GENETIC CONDITION - Methods and compositions for a genetic disease are provided. | 2014-04-03 |
20140093914 | EXPRESSION VECTOR FOR ANIMAL CELLS INCLUDING CSP-B 5'-SAR FACTOR AND METHOD FOR PRODUCING RECOMBINANT PROTEINS USING SAME - The present invention relates to an expression vector for animal cells, comprising: (a) CSP-B (Cytotoxic Serine Protease-B) 5′-SAR (Scaffold or Matrix Attachment Region); (b) a promoter operable in animal cells; and (c) a polyadenylation sequence, and to a method for producing recombinant proteins using same. The vector of the present invention includes CSP-B 5′-SAR, and thus has the effect of overcoming the inhibition of gene expression according to the position of a foreign gene introduced into an animal cell, and significantly improving the expression rate of a target protein. The vector of the present invention effectively expresses recombinant proteins for drugs or antibodies in animal cells. The vector of the present invention and the method for producing recombinant proteins using same may be very usefully applied to the industrial mass production of drugs. | 2014-04-03 |
20140093915 | IL-18 RECEPTOR ANTIGEN BINDING PROTEINS - Provided herein are IL-18 receptor antigen binding proteins and polynucleotides encoding the same. Expression vectors and host cells comprising the same for production of the antigen binding proteins are also provided. In addition, provided are compositions and methods for diagnosing and treating diseases mediated by IL-18 receptor. | 2014-04-03 |
20140093916 | IMMOBILIZED TRANSPOSASE COMPLEXES FOR DNA FRAGMENTATION AND TAGGING - The present invention provides a simple and rapid method for preparing purified transposase complexes that are highly suited for fragmenting DNA. The method includes forming transposase complexes with oligonucleotide adapters in cell lysate, then purifying the complexes from the other substance in the cell lysate. Purification is accomplished using a specific binding pair, in which one member of the pair is bound to an oligonucleotide adapter of the complex and the other member of the pair is bound to a solid substrate. The bound complexes can be immediately used in DNA fragmentation reactions to produce solid substrate-bound DNA fragments, which can be used for any number of purposes, including as templates for amplification and sequencing. | 2014-04-03 |
20140093917 | METHODS FOR CONVERTING LIGNOCELLULOSIC MATERIAL TO USEFUL PRODUCTS - The present invention provides compositions and methods for the pretreatment of lignocellulosic material. The present invention further provides for pretreated lignocellulosic material that can be used to produce useful products, such as fermentable sugars. | 2014-04-03 |
20140093918 | METHODS FOR CONVERTING LIGNOCELLULOSIC MATERIALS TO USEFUL PRODUCTS - The present invention provides compositions and methods for the pretreatment of lignocellulosic material. The present invention further provides for pretreated lignocellulosic material that can be used to produce useful products, such as fermentable sugars. | 2014-04-03 |
20140093919 | Polypeptides Having Endoglucanase Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2014-04-03 |
20140093920 | METHODS FOR TREATING LIGNOCELLULOSIC MATERIALS - The present invention provides compositions and methods for the pretreatment of lignocellulosic material. The present invention further provides for pretreated lignocellulosic material that can be used to produce products, such as fermentable sugars. | 2014-04-03 |
20140093921 | BACTERIA AND METHOD FOR SYNTHESIZING FATTY ACIDS - There is provided a recombinant bacterium comprising at least one overexpressed acyl-ACP thioesterase gene, and wherein at least one gene from the tricarboxylic acid cycle or glycolysis or both is inactivated. There is also provided a method for producing fatty acids, said method comprising culturing bacteria comprising at least one overexpressed acyl-ACP thioesterase gene in a growth medium in a container having walls; allowing said bacteria to secrete fatty acids; and collecting said fatty acids. Acid supplementation is also shown to increase productivity. | 2014-04-03 |
20140093922 | MICROBIAL CULTURE MEDIUM AND CULTURAL METHOD - The present invention discloses a microbial culture medium and a cultural method. The culture medium comprises a combination of strong acid-weak alkali salts and strong alkali-weak acid salts so that pH value thereof can be regulated and controlled in a stable and suitable range by itself, thus decreasing or eliminating an operable regulation on pH value via an external device in fermentation process and a risk of contaminations resulted from it in fermentation process as well, accordingly greatly improving the controllability and stability of the fermentation process. Meanwhile the ammonium salts acting as strong acid-weak alkali salts can be used as a nitrogen source to replace yeast cream to realize a decreased amount of nitrogen resource of high price, therefor sharply reducing the cost of the culture medium. | 2014-04-03 |
20140093923 | Methods and Compositions for the Extracellular Transport of Biosynthetic Hydrocarbons and Other Molecules - The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into hydrocarbons, e.g., n-alkanes and n-alkenes, wherein the n-alkanes are secreted into the culture medium via recombinantly expressed transporter proteins. In particular, the use of such organisms for the commercial production of n-alkanes and related molecules is contemplated. | 2014-04-03 |
20140093924 | Biofilm Photobioreactor System And Method Of Use - Flat panel biofilm photobioreactor systems with a photosynthetic, autofermentative microorganism that forms a biofilm and methods for using the same to make metabolic intermediate compound(s) through photosynthesis and to convert metabolic intermediate compound(s) into chemical product(s) such as a biofuel or a feedstock through autofermentation. | 2014-04-03 |
20140093925 | RECOMBINANT MICROORGANISMS FOR PRODUCING ORGANIC ACIDS - Recombinant microorganisms that co express enzymatic glucose-6-phosphate dehydrogenase and malate dehydrogenase are generated to produce organic acids. | 2014-04-03 |
20140093926 | INTEGRATED SYSTEMS AND METHODS FOR ORGANIC ACID PRODUCTION - Crude bio-based organic acid-producing feedstock is used to produce a bio-based organic acid. Related systems and methods are also described such as an integrated method including a step of producing a crude polyol product and then processing the crude polyol product to produce a bio-based organic acid. | 2014-04-03 |
20140093927 | Variant Sucrose Transporter Polypeptides That Enable Faster Sucrose Utilization In Bacteria - Variant sucrose transporter polypeptides that enable faster sucrose utilization in bacteria are described. Additionally, variant or recombinant bacteria comprising these variant sucrose transporter polypeptides, and methods of utilizing the bacteria to produce products such as glycerol and glycerol-derived products are provided. | 2014-04-03 |
20140093928 | Methods and Systems for Biologically Producing Methanol - A method for biologically producing methanol is disclosed. In some embodiments, the method includes the following: providing a biomass including ammonia oxidizing bacteria having ammonia monooxygenase enzymes and hydroxylamine oxidoreductase enzymes; feeding ammonia to the ammonia oxidizing bacteria; feeding a non-substrate-organic compound including methane to the ammonia oxidizing bacteria; feeding oxygen and reducing equivalents (in the form of hydroxylamine) to the ammonia oxidizing bacteria; oxidizing the ammonia using the ammonia monooxygenase enzymes in the ammonia oxidizing bacteria to generate hydroxylamine and oxidizing the hydroxylamine using the hydroxylamine oxidoreductase enzymes to form nitrite; and partially oxidizing the methane in the compound using the ammonia monooxygenase enzymes in the ammonia oxidizing bacteria to generate methanol. | 2014-04-03 |
20140093929 | FATTY ALCOHOL FORMING ACYL REDUCTASES (FARS) AND METHODS OF USE THEREOF - The present disclosure provides methods useful for producing fatty alcohol compositions from recombinant host cells. The disclosure further provides variant fatty acyl-CoA reductase (FAR) enzymes, polynucleotides encoding the variant FAR enzymes, and vectors and host cells comprising the same. | 2014-04-03 |
20140093930 | Polypeptides with Ketol-Acid Reductoisomerase Activity - Polypeptides having ketol-acid reductoisomerase activity are provided. Also disclosed are recombinant host cells comprising isobutanol biosynthetic pathways employing such polypeptides. Methods for producing isobutanol employing host cells comprising the polypeptides having ketol-acid reductoisomerase activity are also disclosed. | 2014-04-03 |
20140093931 | PRODUCTION OF FERMENTATION PRODUCTS - The invention relates to processes for the production of fermentation products such as alcohols including ethanol and butanol, and the development of microorganisms capable of producing fermentation products via an engineered pathway in the microorganisms. | 2014-04-03 |
20140093932 | DEVICES, SYSTEMS, AND METHODS FOR THE FABRICATION OF TISSUE UTILIZING UV CROSS-LINKING - Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink, and support material; a UV light module for optionally exposing the contents of at least one cartridge to UV light; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Also described herein are methods of using and bioprinting cartridges for such bioprinters. | 2014-04-03 |
20140093933 | MICROBIAL CELL AND PARTICLE SELECTION SYSTEM AND METHOD OF USE - The invention comprises two key components: dielectrophoresis (DEP) and reversible binding surfaces. DEP has become an important tool for trapping dielectric particles. Moreover, DEP can manipulate cell movement as dictated by the intrinsic dielectric constant of the cell without modification. DEP therefore provides a mechanism by which to force targets in a flow channel to a reversible binding surface. By building selectivity into the binding surface, the capacity to choose which targets can be held after the dielectric field is turned off, providing a separation strategy that does not suffer from fouling issues, as large foulants can freely pass over the surface through the flow channel. | 2014-04-03 |
20140093934 | SUBSTRATES COMPRISING SWITCHABLE FERROMAGNETIC NANOPARTICLES - In a process for producing organic substrate particles bonded to switchable ferromagnetic nanoparticles with a mean particle diameter in the range from 10 to 1000 nm, the ferromagnetic nanoparticles used are those nanoparticles which are nonferromagnetic at first, but become ferromagnetic when the temperature is lowered, these at first nonferromagnetic nanoparticles in dispersed form are bonded to the organic substance particles, and then the nanoparticles bonded to the substrate particles are made ferromagnetic as a result of the temperature being lowered. | 2014-04-03 |
20140093935 | CHARGED TRIPLET-STATE QUENCHERS FOR MITIGATION OF PHOTO-INDUCED DAMAGE - Mitigation of photo-induced damage in excitation illuminated reactions and analyses utilizing such reactions results in an enhanced performance for the reactions and the analyses. There is provided a novel class of triplet-state quenchers for mitigating photo-induced damage which are both simple in structure and effective at preventing and/or reducing photo-induced damage to reaction components of excitation illuminated reaction mixtures. Also provided are methods of using the compounds of the invention, devices and kits incorporating the compounds of the invention. | 2014-04-03 |
20140093936 | TYPE II RESTRICTION MODIFICATION SYSTEM METHYLATION SUBUNIT OF ALICYCLOBACILLUS ACIDOCALDARIUS - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 2014-04-03 |
20140093937 | PROTEIN REMOVAL AGENT - The present invention provides compositions, methods and kits for the removal of proteins from complex reaction mixtures useful in majority workflows of molecular biology research experiments. More specifically, such compositions, methods and kits are useful in such processes as purification of nucleic acids from biological samples or after their treatment with specific enzymes, when residual enzyme activity in reaction mixture is not compatible with downstream applications. | 2014-04-03 |
20140093938 | Method of Removing Nucleic Acid Contamination in Reverse Transcription and Amplification Reactions - The invention provides methods of removing nucleic acid contamination from reverse transcription reactions and hot-start PCR, wherein said hot-start PCR is a barrier hot-start PCR set up and/or involves a hot-start DNA polymerase, which methods comprise use of a DNase that is substantially irreversibly inactivated by heating at a temperature of about 50° C. for 5 minutes, and that is substantially specific for double stranded DNA. The invention further provides a DNase that is substantially irreversibly inactivated by heating at a temperature of about 50° C. for 5 minutes, and that is substantially specific for double stranded DNA, nucleic acids encoding said DNase and kits or compositions comprising said DNase or said nucleic acid. | 2014-04-03 |
20140093939 | TANNASE, GENE ENCODING SAME, AND PROCESS FOR PRODUCING SAME - Disclosed is a thermostable tannase derived from a microorganism. Specifically disclosed is a thermostable tannase derived from | 2014-04-03 |
20140093940 | Polypeptides Having Cellulolytic Enhancing Activity And Nucleic Acids Encoding Same - The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 2014-04-03 |
20140093941 | PROKARYOTIC RNAi-LIKE SYSTEM AND METHODS OF USE - Provided herein are methods for inactivating a target polynucleotide. The methods use a psiRNA having a 5′ region and a 3′ region. The 5′ region includes, but is not limited to, 5 to 10 nucleotides chosen from a repeat from a CRISPR locus immediately upstream of a spacer. The 3′ region is substantially complementary to a portion of the target polynucleotide. The methods may be practiced in a prokaryotic microbe or in vitro. Also provided are polypeptides that have endonuclease activity in the presence of a psiRNA and a target polynucleotide, and methods for using the polypeptides. | 2014-04-03 |
20140093942 | GENE, ARS-R ANCHORAGE CASSETTE, ARS-R EXPRESSION-ANCHORAGE CASSETTE, RECOMBINANT PLASMID, BACTERIAL TRANSGENIC LINEAGE, USE OF SAID GENE, USE OF SAID LINEAGE IN ENVIRONMENTAL BIOREMEDIATION PROCESSES - The present invention relates to the construction and insertion of a DNA plasmid vector of broad spectrum for Gram-Negative bacteria, that carries a gene sequence which, when expressed, enables the anchorage of a chelator protein for arsenic ions on the Gram-Negative bacteria cellular surface. For that end, the structural sequence of the regulatory arsR gene without stop codon (SEQ ID No 1) was amplified by Polymerase Chain Reaction (PCR) using as a template the chromosome 1 of | 2014-04-03 |
20140093943 | METHODS OF TREATING A SURFACE AND COMPOSITIONS FOR USE THEREIN - This invention relates to compositions comprising certain fungal serine proteases and methods of treating a surface, preferably a textile using such compositions including the use of such compositions to clean a surface. | 2014-04-03 |