14th week of 2022 patent applcation highlights part 29 |
Patent application number | Title | Published |
20220107237 | METHOD FOR REDUCING THE HYSTERESIS ERROR AND THE HIGH FREQUENCY NOISE ERROR OF CAPACITIVE TACTILE SENSORS - A method for reducing hysteresis error and high frequency noise error of capacitive tactile sensors includes the following steps: step | 2022-04-07 |
20220107238 | DYNAMIC LOAD CENTER-OF-GRAVITY DETECTION - A method determines the combined center of gravity for a materials-handling vehicle and its payload. The method picks up the payload, positions the payload to a first height; subjects the vehicle to a first acceleration force, determines a first pressure in a tilt cylinder, positions the payload to a second height, subjects the vehicle to a second acceleration force, determines a second pressure in the tilt cylinder, and calculates a position of the combined center of gravity of the materials-handling vehicle and the payload. A materials-handling vehicles incorporates a mast, a lift carriage configured to move a payload vertically, a tilt cylinder configured to tilt the mast, a pressure sensor configured to measure a pressure within the tilt cylinder, and a processor configured to calculate a position of the combined center of gravity of the materials-handling vehicle and the payload. | 2022-04-07 |
20220107239 | SYSTEMS AND METHODS FOR EFFICIENTLY IDENTIFYING GAS LEAK LOCATIONS - Systems and methods for efficiently identifying gas leak locations may include traversing, by an investigator and within a search area in which a gas leak has been indicated, a route defined according to at least one of a surge-cast algorithm or a surge-spiral algorithm. The systems and methods may also include sampling, with a gas detection device carried by the investigator, an environment along the route to identify a location of the gas leak. | 2022-04-07 |
20220107240 | VALVE DIAGNOSTIC AND PERFORMANCE SYSTEM - A seat leak measurement system for a ball valve is described. The system includes: a ball valve with a cavity drain line, the ball valve including a cavity pressure sensor; a valve seat leak measurement apparatus including: a cable with a connector, the connector having an external grounding cable; an apparatus electronic control system in communication with the valve sensor retrieval fitting and with valves of the valve seat; an fluid inlet line with a quick pipe coupler, the fluid inlet line having an apparatus drain valve and an isolation valve; a pressure indicator transmitter connected to the fluid inlet line, the pressure indicator transmitter in electronic communication with the apparatus electronic control system; a temperature indicator transmitter connected to the fluid inlet line, the temperature indicator transmitter in electronic communication with the apparatus electronic control system; and a flow elements manifold receiving fluid from the fluid inlet line. | 2022-04-07 |
20220107241 | METHOD FOR CORRECTING A LIGHT PATTERN, AUTOMOTIVE LIGHTING DEVICE AND AUTOMOTIVE LIGHTING ASSEMBLY - A method for correcting a first light pattern provided by a lighting device with a matrix of light sources. The method includes steps of providing some resolution data of the light sources, simulating a test map of the light pattern using the resolution data, and simulating distortion maps of the test map. Each distortion map is associated to a distortion factor. Also included is obtaining a real distorted light pattern, comparing the real distorted light pattern with the distortion maps, finding a distortion map which is the most similar to the real distorted map and applying a correction factor to correct the real distorted light pattern, thus obtaining a corrected light pattern. The correction factor is related to the distortion factor of the distortion map which is the most similar to the real distorted map. | 2022-04-07 |
20220107242 | MULTI-MODE MICROWAVE WAVEGUIDE BLADE SENSING SYSTEM - A multi-mode microwave waveguide blade sensing system includes a transceiver, a waveguide, and a probe sensor. The transceiver generates a microwave energy signal having a first waveguide mode and a different second waveguide mode. The waveguide includes a first end that receives the microwave energy signal. The probe sensor includes a proximate end that receives the microwave energy signal from the transceiver and a distal end including an aperture that outputs the microwave energy signal. The probe sensor directs the microwave energy signal at a first direction based on the first waveguide mode and a different second direction different based on the second waveguide mode. The probe sensor receives different levels of reflected microwave energy based at least in part on a location at which the at least one microwave energy signal is reflected from the machine. | 2022-04-07 |
20220107243 | APPARATUS AND METHOD FOR INSPECTING SEAT MOTOR NOISE - An apparatus for inspecting seat motor noise includes: a soundproof booth provided on a transfer path of a seat assembly and installed with an opening/closing door at both sides along a transfer direction of the seat assembly; a power supply portion provided within the soundproof booth and configured to apply power to respective seat motors of the seat assembly; a noise detection unit installed within the soundproof booth and configured to detect an operation noise of the seat motors; and a controller configured to determine whether the seat motors are defective in noise based on comparison of noise data detected by the noise detection unit to predetermined reference data. | 2022-04-07 |
20220107244 | THERMAL EXTRACTION APPARATUS WITH HIGH VOLUME SAMPLING TRAP - In an example, a thermal extraction apparatus includes: a housing having a gas inlet and a gas outlet to receive a gas flow through the housing from the gas inlet to the gas outlet, and a side opening to receive a sample collector, having a sample collector adsorbent containing a vapor sample, into a sample collector location; a pump to generate the gas flow; a heater to heat the sample collector adsorbent of the sample collector to a temperature sufficient to release the vapor sample; a thermal desorption (TD) tube connected with the gas outlet of the housing to receive the gas flow downstream of the sample collector and collect the vapor sample released from the sample collector adsorbent of the sample collector; and a cooling member in heat exchange with the TD tube to cool the TD tube. | 2022-04-07 |
20220107245 | METHODS FOR PREPARING LIVE CELLS FOR ANALYSIS AND DETERMINING LOCALIZATION OF MEMBRANE-BOUND PROTEINS - Methods of preparing live cells for analysis, including methods that may be used with electron microscopy (EM) for localization of membrane proteins to achieve reduced morphological damage to cellular membranes and membrane-bound organelles. Such a method involves performing a chemical fixation process on a cellular sample comprising live cells, and then performing a cryofixation process with extended osmication during freeze substitution on the cellular sample. | 2022-04-07 |
20220107246 | NONCOVALENT TAGS AND RELATED METHODS FOR CYTOSOLIC DELIVERY OF MACROBIOMOLECULES - The disclosure provides bifunctional tag constructs and related methods useful for transporting macrobiomolecules, such as nucleic acids and proteins, across plasma membranes. The bifunctional tags comprise an affinity domain conjugated to hydrophobic domain. The affinity domain is configured to noncovalently bind to the macrobiomolecule, whereas the hydrophobic domain is configured to interact with the plasma membrane. In certain embodiments, the plurality of bifunctional tags can noncovalently associate along the length of a macrobiomolecule, thus increasing the interaction with and penetration through the plasma membrane. | 2022-04-07 |
20220107247 | Material Testing System - According to an embodiment of the present invention, there is provided a material testing system, comprising: a material testing apparatus configured to receive an electrical supply, wherein the material testing apparatus comprises: guide means; sample holding means configured for holding a sample; force means configured for applying force to the sample; a crosshead arranged to support at least a portion of one or both of the sample holding means and the force means, wherein the crosshead is moveable about the guide means; wherein the material testing system comprises a three phase switched-mode power supply unit arranged to provide the electrical supply to the material testing apparatus. | 2022-04-07 |
20220107248 | FASTENING ASSEMBLY FOR FASTENING A TEST DEVICE HOLDER TO A FORCE-MEASURING APPARATUS, FORCE-MEASURING APPARATUS HAVING A FASTENING ASSEMPLY OF THIS TYPE, TEST DEVICE HOLDER, AND SLIDE PART FOR A FORCE-MEASURING APPARATUS - The invention relates to a fastening assembly ( | 2022-04-07 |
20220107249 | FASTENING ARRANGEMENT FOR FASTENING A SAMPLE HOLDER TO A FORCE MEASUREMENT DEVICE, SAMPLE HOLDER AND COUNTERPART HOLDER FOR A FASTENING ARRANGEMENT OF SAID TYPE, AND FORCE MEASUREMENT DEVICE HAVING A FASTENING ARRANGEMENT OF SAID TYPE - The invention relates to a fastening arrangement ( | 2022-04-07 |
20220107250 | MATERIAL TESTING MACHINES WITH MOVABLE LOWER CROSSBEAMS - Described herein are examples of improved material (and/or universal) testing machines having a lower crossbeam that may be moved via a drive system of the material testing machine. In some examples, this may be accomplished via drive shafts with different threading in upper and lower portions, and/or independent drive systems for upper and lower crossbeams. The ability to dynamically adjust (e.g., raise) the lower crossbeam may allow an operator to interact with test samples at a more comfortable height, and reduce the need for an operator to repeatedly bend and/or kneel. | 2022-04-07 |
20220107251 | EMBEDDED SENSOR DEVICES AND METHODS - Many construction materials are chemically active materials whose structural properties parameters, physical-mechanical properties, etc. need to be determined. By exploiting embedded wireless sensors within these materials from initial wet manufactured state to final solid capillary-porous material assessment of initial and subsequent properties can be established allowing determination of current and future performance of the construction material. Embedded sensors can also monitor lifetime properties to identify performance degradations in the construction material as well as other construction elements embedded within or around the construction material. Further, the data accumulated from initial manufacturing to extended lifetime allows for additional assessments and improvements with respect to selection of construction material mix for a particular project at a particular location and time, improving the assessment of proactive repair and/or remedial work, quality control monitoring, cost reduction etc. | 2022-04-07 |
20220107252 | FORCE MEASURING ARRANGEMENT, FORCE MEASURING APPARATUS HAVING SUCH A FORCE MEASURING ARRANGEMENT, AND METHOD USING SUCH A FORCE MEASURING ARRANGEMENT - The invention relates to a force measuring arrangement ( | 2022-04-07 |
20220107253 | MEASURING SYSTEM, OVERHEAD MOVING DEVICE, AND MEASURING METHOD - A measuring system includes a plurality of support posts, a winding device configured to wind a cable supported by the support posts, a winding device configured to wind the cable, a hoisting device coupled to the cable and configured to move in an air when the cable is wound by the winding device, and a measuring device hung from the hoisting device and configured to measure a strength of a tree. | 2022-04-07 |
20220107254 | HIGH THROUGHPUT TRIBOMETER - The present invention relates, in part, to systems for characterizing force (e.g., friction, and wear). In one embodiment, a tribometer allows for wear testing of samples in a high throughput manner. | 2022-04-07 |
20220107255 | GOBLET VISCOMETER - The present disclosure provides a viscometer for measuring rheological properties of a fluid, based on the fluid level decreasing at a constant rate during efflux, including a vessel with a three dimensional shape defined by the following proportionality | 2022-04-07 |
20220107256 | METHOD AND APPARATUS FOR PREDICTING FLUID FLOW THROUGH A SUBJECT CONDUIT - A model-order reduction system and methods are described for providing a fast fluid flow simulation model of fluid flow in a conduit such as a blood vessel with stenosis. A first method is described for generating a reduced generic numerical model ( | 2022-04-07 |
20220107257 | VISCOMETER SYSTEM - This disclosure provides a system for measuring rheological properties of a fluid including a vessel with a shape defined by the following proportionality: x∝C | 2022-04-07 |
20220107258 | Method and apparatus to search for, find, collect and confirm the presence of ptentially dangerous airborne particles such as COVID-19 VIRUS - A light scattering method and apparatus are disclosed whereby the presence of the COVID-19 virus in a designated volume of ambient air may be confirmed within a few hours from the analysis of its contents. By such means, the near real-time presence of viral constituents within airborne regions of meetings, gatherings, presentations, and even the ICUs of hospitals themselves, may be confirmed and often quantified. The present invention provides such means to find, separate, and identify specifically such fractions: an important early warning of their presence and the current dangers they pose. The same methods described may be applied also for the detection of airborne bacteria. | 2022-04-07 |
20220107259 | AIR MEASUREMENT DEVICE - An inexpensive, yet accurate particle matter (e.g., PM) detector is described that combines the features of two different optical particle sensors with a modeling tool to provide a comprehensive, effective air quality measurement instrument (e.g., sensing instrument). The modeling tool enables the use of a combination low cost optical particle sensors, such as a nephelometer and an optical particle counter to determine the amounts of unhealthy particles that are present in air. The sensing instrument determines the total mass loading at specific size breakpoints, such as PM | 2022-04-07 |
20220107260 | METHOD FOR PROCESSING AND DISPLAYING MULTI-CHANNEL SPECTRAL HISTOGRAMS AND SYSTEMS FOR SAME - Aspects of the present disclosure include methods for processing and displaying multi-channel spectral histograms. Methods according to certain embodiments include obtaining a histogram of cytometric data for a sample, wherein the cytometric data comprises measurements from particles irradiated in the sample flowing in a flow stream, generating the representation of the histogram by encoding the histogram, the encoding comprising: assigning a color to each histogram value in the representation of the histogram, and duplicating each color corresponding to each histogram value in the representation of the histogram a predetermined number of times, and using the representation of the histogram for displaying the histogram. Systems for practicing the subject methods are also provided. Non-transitory computer readable storage mediums are also described. | 2022-04-07 |
20220107261 | FLOW CELL FOR FIBER OPTIC SPECTROMETERS AND PHOTOMETERS - A flow cell and flow cell system which allows for calibration of an attached sensor to be performed in place. Specifically, the ability to utilize standard addition techniques of calibration without the need to take a test sample from the process stream or remove the sensor from operating on the flow cell. | 2022-04-07 |
20220107262 | A CARTRIDGE COMPRISING A CHANNEL FOR A FLUID SAMPLE, AN ASSEMBLY COMPRISING THE CARTRIDGE AND A METHOD OF ALIGNING AN OPTICAL DEVICE WITH THE CHANNEL OF THE CARTRIDGE - According to the present invention there is provided a cartridge ( | 2022-04-07 |
20220107263 | METAMATERIAL-BASED IR EMITTER HAVING MODULATABLE EMISSIVITY - The invention relates to a modulatable infrared emitter comprising a heating element, a planar base element, a dielectric interlayer, and a planar cover element which is a structured metamaterial, and an actuator, wherein the actuator is configured for a relative movement of the cover element and the base element between a first and a second position in order to modulate the intensity of the emission of the infrared emitter. The invention further relates to production methods for the infrared emitter, methods for the modulated emission of infrared red radiation by means of the infrared emitter, and preferred uses of the infrared emitter. A system comprising the infrared emitter and a control device for regulating the actuator are also preferably the subject matter of the invention. | 2022-04-07 |
20220107264 | METHOD FOR DETECTING GAS CONCENTRATION IN GLASS BOTTLE WITH DYNAMICAL THRESHOLD ADJUSTMENT - A method for detecting gas concentration in a glass bottle: firstly, second harmonic peaks P | 2022-04-07 |
20220107265 | Methods and Apparatuses for Spectrophotometric Determination of Contents and Turbidity of a Liquid Sample - A method for determining contents of sample liquids spectrometrically includes an empty-state measurement with no liquid present, to obtain an empty-state light intensity measurement I | 2022-04-07 |
20220107266 | METHOD AND DEVICE FOR DETERMINING A SOLID STATE FORM OF WATER ON A ROADWAY SURFACE - A method for ascertaining a solid physical state of water on a roadway surface. The method encompasses: emitting light having at least two predefined wavelengths or predefined wavelength ranges which differ from one another; receiving a signal representing an intensity of a portion of the emitted light which is scattered back by the roadway surface to an optical sensor; ascertaining a solid physical state of water on a roadway surface based on a ratio of received values for light intensities of the respective predefined wavelengths or predefined wavelength ranges within the signal; classifying the solid physical form of water on the roadway surface by reconciling absolute values of the signal with a first predefined threshold value and/or by reconciling a signal-to-noise ratio of the signal with a second predefined threshold value; and using the ascertained information regarding the solid physical state of the water in the transportation device. | 2022-04-07 |
20220107267 | Solid Dosage Component Measurement Device and Solid Dosage Component Measurement Method - A solid dosage component detection method for a solid dosage component measurement device comprises generating a transmitting electromagnetic wave with a terahertz frequency and emitting to a solid dosage component; detecting a receiving electromagnetic wave with a terahertz frequency through the solid dosage component; comparing the transmitting electromagnetic wave incident on the solid dosage component with the receiving electromagnetic wave received from the solid dosage component to detect a plurality of signal characteristics differences between the transmitting and receiving electromagnetic waves; and discriminating polymorphism of a testing pharmaceutical in the solid dosage component, calculating a concentration of the testing pharmaceutical in the solid dosage component, and analyzing a coating layer thickness and a porosity of the solid dosage component based on the plurality of signal characteristics differences. | 2022-04-07 |
20220107268 | TERAHERTZ SPECTRUM MEASUREMENT METHOD AND SYSTEM BASED ON UNEQUAL OPTICAL PATH METHOD - Terahertz spectrum measurement method and system based on an unequal optical path method is provided. By using a Femtosecond laser and a Terahertz time-domain spectroscopy system, samples to be measured and having different thicknesses are subjected to scanning by time-domain Terahertz signals to obtain transmission signals of the samples with two different thicknesses. The signal after passing through a sample with the thickness of d | 2022-04-07 |
20220107269 | REFRACTOMETER WITH SINGLE USE PRISM AND REUSABLE OPTICAL SYSTEM - A refractometer includes an enclosure, a single use prism, a light source, and an index of refraction (IoR) sensor. The single use prism is removably disposed within the enclosure. The light source and IoR sensor are disposed within the housing and are configured to be repeatably used with a series of single use prisms of similar construction. One single use prism can be removed after being used, and a new single use prism can be installed in the enclosure for use with the same light source and IoR sensor as were used with the first prism. | 2022-04-07 |
20220107270 | LIGHT SCATTERING DETECTORS AND SAMPLE CELLS FOR THE SAME - Sample cells, light scattering detectors utilizing the sample cells, and methods for using the same are provided. The sample cell may include a body defining a flowpath extending axially therethrough. The flowpath may include a cylindrical inner section interposed between a first outer section and a second outer section. The first outer section may be frustoconical. A first end portion of the first outer section may be in direct fluid communication with the inner section and may have a cross-sectional area relatively smaller than a cross-sectional area at a second end portion thereof. The body may further define an inlet in direct fluid communication with the inner section. The inlet may be configured to direct a sample to the inner section of the flowpath. | 2022-04-07 |
20220107271 | MICROPARTICLE ANALYSIS DEVICE, ANALYSIS DEVICE, ANALYSIS PROGRAM, AND MICROPARTICLE ANALYSIS SYSTEM - A microparticle analysis device ( | 2022-04-07 |
20220107272 | Coated Fiber Optic Chemical and Radiation Sensors - Distributed fiber optic chemical and radiation sensors formed by coating the fibers with certain types of response materials are provided. For distributed chemical sensors, the coatings are reactive with the targets; the heat absorbed or released during a reaction will cause a local temperature change on the fiber. For distributed radiation sensors, coating a fiber with a scintillator enhances sensitivity toward thermal neutrons, for example, by injecting light into the fiber. The luminescent components in these materials are taken from conjugated polymeric and oligomeric dyes, metal organic frameworks with sorbed dyes, and two-photon-absorbing semiconductors. The compositions may exhibit strong gamma rejection. Other scintillators combining luminescent materials with neutron converters are available. With a multiple-layer coating, it may be possible to identify the presence of both neutrons and gamma rays, for example. Coatings may be applied during manufacture or in the field. | 2022-04-07 |
20220107273 | Coated Fiber Optic Chemical and Radiation Sensors - Distributed fiber optic sensors formed by covering the fibers with tubing are provided. The tubing including responsive materials formulated or configured to, responsive to exposure to one of a target chemical species and a target radiation particle, change a relative size and generate a localized effect on or in the optical fiber. | 2022-04-07 |
20220107274 | PHOTONIC APPARATUS, METHODS, AND APPLICATIONS - An optical microtoroid resonator including one or more nanoparticles attached to a surface of the resonator and capable of receiving an input signal from afar-field source (via free-space transmission) and outputting light propagating within the optical apparatus. A method for coupling light into and out of an optical resonator using a nanoparticle or nanoparticles to interface with spatially separated far-field optical elements. | 2022-04-07 |
20220107275 | METHOD FOR INSPECTING REFRIGERANT PIPE AND REFRIGERANT PIPE - Provided are a method for inspecting a refrigerant pipe, the method being able to quickly determine durability, and a refrigerant pipe confirmed to be highly durable. The method is a method for inspecting a refrigerant pipe containing copper or a copper alloy. In the method, the refrigerant pipe is exposed to an aqueous alkaline solution and inspected based on a color change of the refrigerant pipe due to exposure of the refrigerant pipe to the aqueous alkaline solution. | 2022-04-07 |
20220107276 | INFRARED DETECTION CAMERA - An infrared detection camera for the inspection of coated substrates. A corrosion sensing instrument is handheld, portable, battery powered, compact and lightweight. The camera performs nondestructive, real time imaging of corrosion and defects beneath painted metal or plastics or composite surfaces. The device includes a user-friendly computer interface for real time imaging and image storage capability and is typically used for detecting early stage corrosion beneath painted aircraft aluminum surfaces. The handheld device has a front “open air” imaging port which is designed to be placed in soft contact against the painted surface to be inspected by the instrument. The device includes an infrared camera and infrared lighting to capture an image of the surface. The captured image is transferred to a computer and analyzed to locate imperfections below a coating on a surface. | 2022-04-07 |
20220107277 | SELF-REFERENCING MICROWAVE SENSING SYSTEM - A system of a machine includes a waveguide system and a radio frequency transceiver/detector coupled to the waveguide system and configured to emit a calibration signal in the waveguide system to establish a reference baseline between the radio frequency transceiver/detector and a calibration plane associated with an aperture of the waveguide system, emit a measurement signal in the waveguide system to transmit a radio frequency signal from the radio frequency transceiver/detector out of the aperture of the waveguide system, and detect a reflection of the measurement signal at the radio frequency transceiver/detector based on an interaction between the measurement signal and a component of the machine. A measurement result of the reflection of the measurement signal can be adjusted with respect to a reflection of the calibration signal. | 2022-04-07 |
20220107278 | X-RAY TUBE BILLING SYSTEM - An X-ray tube billing system for a fluoroscopic apparatus for non-destructive inspection configured to perform X-ray fluoroscopy on a subject using an X-ray tube includes a fluoroscopy time detector configured to detect a length of time during which the X-ray fluoroscopy has been performed using the X-ray tube, and a billing amount calculator configured to calculate a billing amount related to use of the X-ray tube based on the length of time during which the X-ray fluoroscopy has been performed, which is detected by the fluoroscopy time detector. | 2022-04-07 |
20220107279 | DATA-DRIVEN SOLUTION FOR INVERSE ELEMENTAL MODELING - Methods for determining mineral compositions of materials are described. The methods include obtaining elemental data associated with a geologic sample, calculating a measurement correlation matrix of the geologic sample from the elemental data, calculating an artificial correlation matrix, comparing the measurement correlation matrix and the artificial correlation matrix to determine an error value, minimizing the error value by updating the artificial correlation matrix and comparing the measurement correlation matrix to the updated artificial correlation matrix, and determining a mineral composition of the geologic sample based on the minimized measurement correlation matrix. | 2022-04-07 |
20220107280 | Defect Inspection Device and Defect Inspection Method - Provided is a quantification method for evaluating the quality of a sample on the basis of a mirror electron image acquired by a mirror electron microscope. In this invention, a mirror electron image is expressed numerically through counting of the brightness values of each pixel composing the mirror electron image, the creation of a brightness histogram, and the calculation, from the distribution of the brightness histogram, of a standard deviation. If brightness contrast is formed on the mirror electron image by, for example, a scratch on or latent damage in a sample, because the brightness values of the pixels will fluctuate, there will be more variation in the brightness values than in an image obtained from a satisfactory sample with no defects, and this will result in the brightness values of the mirror electron image having a larger standard deviation. The standard deviation indicates the variation in the brightness calculated from the mirror electron image and essentially represents the degree of defect contrast in the sample. This value can be used as a basis for simply evaluating the quality of a sample while eliminating subjectivity and ambiguity. | 2022-04-07 |
20220107281 | VARIABLE GAP THERMAL CONDUCTIVITY APPARATUS AND METHOD - An apparatus and a method for determining the thermal conductivity of a fluid specimen are provided. The apparatus and the method include determining thermal conductivity using a quasi-steady state variable gap axial flow technique. The fluid specimen is heated on one side by a heat source with a known power output and cooled on the other side. After reaching steady state, a resulting temperature drop through the fluid specimen exists. This temperature drop, the known fluid specimen thickness (or gap distance), and the known power output are used to calculate the thermal resistance of the fluid specimen. The thermal conductivity of the fluid specimen is then determined using a curve fit of thermal resistance with respect to gap distance. | 2022-04-07 |
20220107282 | APPARATUS, METHODS AND COMPUTER PROGRAMS FOR ANALYSING CELLULAR SAMPLES - Examples of the disclosure relate to systems and methods for analysing cellular samples. The systems can comprise apparatus comprising means for providing a stimulating signal to a cellular sample wherein the stimulating signal stimulates the cellular sample so as to modify one or more electrical properties of the cellular sample and providing a plurality of electrical input signals having a plurality of different frequencies to the cellular sample. The apparatus can also comprise means for receiving electrical output signals from the cellular sample where the electrical output signals correspond to the electrical input signals and the values of the electrical output signals are determined by the modified electrical properties of the cellular sample; and enabling spectroscopic analysis of the electrical output signals to identify a type of cell in the cellular sample from the modified electrical properties. | 2022-04-07 |
20220107283 | CHARACTERIZATION OF FLUID INSIDE PIPE USING MULTI FREQUENCY ELECTRICAL SIGNAL - A multi-frequency signal may be used to induce voltage difference across a portion of a pipe. The voltage difference may be induced to take multi-frequency measurement of impedance characteristics of fluid inside the pipe. The multi-frequency measurement of the impedance characteristic of the fluid inside the pipe may be used to determine a characteristic of the fluid inside the pipe. This may be achieved by active integration of experimental data with high-resolution multi-frequency electrical impedance tomography (MFEIT) modeling. | 2022-04-07 |
20220107284 | MECHANISM FOR THE REAL-TIME PREDICTION OF INCIPIENT FAILURE IN WORKING FLUIDS - A system and method for determining whether a working fluid being used in a machine is near its failure point. The system includes an impedance/admittance sensor having a flow chamber through which the working fluid flows and a pair of spaced apart electrodes. A function generator generates frequency signals at certain frequencies over a range of frequencies and a sensor circuit receives the frequency signals and provides the frequency signals to the electrodes, where the conductance of the working fluid creates a measurement signal in the sensor circuit. A processor is responsive to the measurement signal and generates a relationship between the frequency signals and the measurement signal that is indicative of a contamination level of the working fluid. | 2022-04-07 |
20220107285 | GAS SENSOR - A gas sensor includes a feedback circuit part and a sensor circuit part. The feedback circuit part includes a reference resistor and a first temperature sensing element which are connected in series, a first heater resistor that heats the first temperature sensing element, and a first amplifier circuit that controls the amount of current to flow in the first heater resistor based on an internal potential. The sensor circuit part includes a second temperature sensing element and a second heater resistor that heats the second temperature sensing element. A current according to the output of the first amplifier circuit flows in the second heater resistor. With this configuration, it is possible to automatically change the amount of current to flow in the second heater resistor according to ambient temperature without digital processing to thereby heat the second temperature sensing element to a constant temperature. | 2022-04-07 |
20220107286 | Apparatus, System And Method For Monitoring External Properties Of Plant Equipment And/Or Pipe Work - The invention provides a sensor system and methods for detecting the presence of water in an insulating material surrounding plant equipment and/or pipe work. The sensor system comprises a plurality of sensors located in and spatially distributed over the insulating material, each sensor being operable to provide a sensor output indicative of the presence of water in an insulating material. The system also comprises at least one reference sensor operable to provide a reference sensor output indicative of the presence of water in an ambient environment in the vicinity of the plurality of sensors. In addition, the system comprises a processor configured to receive the sensor outputs from the plurality of sensors and the reference sensor output. The processor is configured to correlate the sensor outputs from the plurality of sensors and the reference sensor output to provide a correlation data output for use in evaluating a corrosion condition. | 2022-04-07 |
20220107287 | SENSOR ELEMENT AND GAS SENSOR - Provided is a sensor element and a gas sensor capable of suppressing a disadvantage resulting from the structure of a diffusion control unit while suppressing the influence of a dynamic pressure resulting from an operation of an engine. A sensor element is used to measure the concentration of a predetermined gas component in a measurement target gas. The sensor element includes an oxygen ion-conductive solid electrolyte. A gas introduction opening is formed at one end portion in the long side direction of the sensor element. An internal cavity is formed inside the sensor element. A diffusion control unit is formed between the gas introduction opening and the internal cavity. The diffusion control unit includes first and second diffusion control units that are arranged along the long side direction. The first diffusion control unit includes a first opening portion. The second diffusion control unit includes a second opening portion. | 2022-04-07 |
20220107288 | GAS SENSOR - The gas sensor is configured to measure a concentration of a predetermined gas component. The gas sensor includes a sensor element. An internal cavity configured to introduce the measurement target gas from an external space is formed inside the sensor element. The sensor element has a long side and a short side in a plan view. In the sensor element, a proportion of a length in the short side direction of a portion that is shortest in the short side direction, out of portions in which the internal cavity is not formed, to the length of the short side is 0.22 or more. The sensor element has an upper face and a lower face. A proportion of a length from the end portion of the internal cavity near the lower face to the lower face, to a thickness of the sensor element, is 0.50 or more and 0.65 or less. | 2022-04-07 |
20220107289 | ONLINE ANALYZERS FOR FLARE GAS PROCESSING - A method includes receiving data characterizing a speed of an acoustic signal through a gas mixture in a pipe. The speed of the acoustic signal can be detected by an ultrasonic flow meter coupled to the pipe. The method also includes receiving data characterizing a concentration of one or more inert gases in the gas mixture detected by an inert gas analyzer. The method further includes determining, based on the received data characterizing the speed of the acoustic signal and the received data characterizing the concentration of the one or more inert gases in the gas mixture, a net heating value of the gas mixture. The method also includes adjusting a processing of the gas mixture based on the determined net heating value. | 2022-04-07 |
20220107290 | METHOD FOR RECONSTRUCTING CRACK PROFILES BASED ON COMPOSITE-MODE TOTAL FOCUSING METHOD - A method for reconstructing the crack profiles based on the composite-mode total focusing method (CTFM), including: selecting the parameters for phased array ultrasonic testing; acquiring the A-scan signal matrix; establishing the coordinate system and grid division of the region of interest (ROI); determining the wave modes; solving the positions of the refracted points; reconstructing the image by CTFM; and realizing the quantification, positioning, and orientation of cracks. The A-scan signal matrix including 21 views is acquired. Based on Fermat's principle, the refracted points at the interface between wedge and sample for the 21 views are calculated, to obtain the corresponding amplitude for each view in the ROI. For each reconstruction point, the strongest response is selected from the 21 views. The profiles of the cracks with different orientation angles are reconstructed by CTFM. | 2022-04-07 |
20220107291 | Total Organofluorine Method for PFAS Using Reductive Defluorination - A method of determining total organofluorine in a sample comprising PFAS, comprising: providing a solution of PFAS in an organic solvent to obtain extracted PFAS, or extracting a sample with an organic solvent to obtain extracted PFAS; treating the extracted PFAS with a sodium metal dispersion and alcohol to obtain sodium fluoride; and quantifying the amount of the fluoride. Surprisingly, we discovered that the method recovered substantial fluorine from PFAS and significantly higher yields obtained by selection of the appropriate alcohols. The method is selective for organofluorine from inorganic fluorine. | 2022-04-07 |
20220107292 | ON-LINE SUPPRESSOR - A device for ion chromatography comprises a tube with an inlet opening and an outlet opening and an inner diameter from about 40 microns to about 10 microns. There is an aperture through one side of the tube into a lumen of the tube. At least a portion of the inner surface of the tube has a first charge. An ion exchange barrier covers the aperture on an outside surface of the tube. The inner surface of the tube, from the inlet opening to the aperture, is coated with ion exchange particles having a diameter ranging from about 30 nm to about 200 nm. The ion exchange particles have a second charge opposite the first charge. The inner surface of the tube, from the outlet opening to the aperture, is not coated with ion exchange particles. | 2022-04-07 |
20220107293 | Analysis Apparatus - An analysis apparatus capable of adjusting holding time of each stream in a plurality of HPLC streams without adjusting a pipe length, and capable of determining degradation of a separation column, a liquid-delivery failure, or the like without removing a pipe from the apparatus is implemented. Air is suctioned from the shipper | 2022-04-07 |
20220107294 | WAVEFORM PROCESSING DEVICE FOR CHROMATOGRAM AND WAVEFORM PROCESSING METHOD FOR CHROMATOGRAM - A sample chromatogram produced by measurement of a mobile phase into which a sample has been injected is acquired by a sample chromatogram acquirer. A background chromatogram produced by measurement of a mobile phase into which a sample is not injected or a mobile phase into which a control sample is injected is acquired by a background chromatogram acquirer. Alignment of a sample chromatogram and a background chromatogram is performed by an alignment processor by causing of baselines of the acquired sample chromatogram and the acquired background chromatogram to coincide with each other. Subtraction processing of subtracting a background chromatogram from a sample chromatogram after alignment is executed by a subtraction processor. | 2022-04-07 |
20220107295 | METHANE SENSOR AUTOMATIC BASELINE CALIBRATION - A method for baseline calibration of methane sensor includes receiving data characterizing methane detection by a sensor and sensor measurement parameters. The received data characterizing methane detection includes a plurality of methane measurements and detection times associated with the plurality of methane measurements. The method also includes determining a first plurality of calibrated methane measurements by at least calibrating the plurality of methane measurement based on the sensor measurement parameters and one or more of a humidity and a temperature associated with the sensor. The method further includes calculating an offset parameter based on a difference between a global baseline reference and one of a previous baseline value and a measurement baseline value associated with the first plurality of calibrated methane measurements. The method also includes providing a second plurality of calibrated methane measurements by at least subtracting the offset parameter from the first plurality of calibrated methane measurements. | 2022-04-07 |
20220107296 | APPARATUS AND METHODS FOR REDUCING FUGITIVE GAS EMISSIONS AT OIL FACILITIES - Apparatus and methods for detecting and reporting pollution at an oil facility are disclosed. The technology utilizes a logic control system to read from a pollution sensor and present the sensed data as a pollutant from a leak. The pollution leakage can be further managed and reduced. | 2022-04-07 |
20220107297 | PLATFORM FOR REAL-TIME IDENTIFICATION AND RESOLUTION OF SPATIAL PRODUCTION ANOMALIES IN AGRICULTURE - A method includes obtaining data measurements associated with plants in at least one growing area. The data measurements are associated with one or more characteristics of the plants and one or more characteristics of the at least one growing area. The method also includes processing at least some of the data measurements to identify one or more anomalous plant production issues associated with the plants. At least one anomalous plant production issue is associated with uneven production by the plants in at least part of the at least one growing area. The method further includes generating at least one visualization presenting at least some of the data measurements or processed versions of at least some of the data measurements in a spatial manner that corresponds to the at least one growing area. The at least one visualization identifies information associated with the one or more anomalous plant production issues. | 2022-04-07 |
20220107298 | SYSTEMS AND METHODS FOR CROP HEALTH MONITORING, ASSESSMENT AND PREDICTION - Systems and methods for monitoring and assessing crop health and performance can provide rapid screening of individual plants. The systems and methods have an automated component, and rely primarily on the detection and interpretation of plant-based signals to provide information about crop health. In some cases knowledge from human experts is captured and integrated into the automated crop monitoring systems and methods. Predictive models can also be developed and used to predict future health of plants in a crop. | 2022-04-07 |
20220107299 | INFORMATION PROCESSING APPARATUS FOR VISUALIZING COLLECTED DATA BY GRAPH, CONTROL METHOD THEREOF, AND STORAGE MEDIUM - An information processing apparatus configured to display results of measurement for a plurality of items about an agricultural crop as a graph, acquires measurement information including an item for which the measurement is performed and a measured value obtained by the measurement, acquires information about a reference value set for each of the plurality of items, performs conversion of the measured value into a display coordinate value on a graph for each of the plurality of items to make reference values agree with each other on the graph, and displays a graph including a plurality of pieces of series data corresponding to the respective plurality of items and having display coordinate values converted by the conversion unit, and an index indicating the reference values for the plurality of items. | 2022-04-07 |
20220107300 | PAAS PLATFORM-BASED ULTRA-LOW POWER CONSUMPTION SOIL NEAR-GROUND WIRELESS SENSING SYSTEM - A PaaS platform-based ultra-low power consumption soil near-ground wireless sensing system includes a plurality of sensors mounted in soil, a signal transceiver module is arranged in the sensor, the signal transceiver module transmits a signal to a LoRaWan gateway through LoRa wireless communication, and the LoRaWan gateway is successively connected to a PaaS platform and a user group; and the sensors include a soil moisture sensor, a soil salinity sensor and a rainfall sensor. The PaaS platform-based ultra-low power consumption soil near-ground wireless sensing system of the invention enables sensor nodes to have ultra-low power consumption; and through fusion with a LoRa communication technology, a node network with ultra-low power consumption and long-distance transmission is constructed. | 2022-04-07 |
20220107301 | SYSTEM FOR THE MEASUREMENT OF RHEOLOGICAL PROPERTIES OF A FLUID - The present disclosure provides a system for the measurement of rheological properties of a fluid including a computing device including memory, one or more processors, and software executable by the one or more processors, configured to accept input parameters including a fluid density and the fluid viscometer drain time; and subsequently output one or more values corresponding to one or more rotations per minute (RPM) dial readings (and in centipoise) of a conventional rheometer. In embodiments, the input parameters may be limited to, or consist of, fluid density and fluid viscometer drain time. In embodiments, the system may output and display six values corresponding to the six RPM dial readings (and in centipoise) of a conventional rheometer corresponding to 600 RPM, 300 RPM, 200 RPM, 100 RPM, 6 RPM, and 3 RPM. | 2022-04-07 |
20220107302 | CALCITE CHANNEL STRUCTURES WITH HETEROGENEOUS WETTABILITY - A method of making a portion of a microfluidic channel includes lithographically patterning a first pattern into a first layer of photoresist disposed on a substrate, the first pattern representative of morphology of a reservoir rock; etching the first pattern into the substrate to form a patterned substrate; disposing a second layer of photoresist onto the patterned substrate; lithographically patterning a second pattern into the second layer of photoresist to reveal portions of the patterned substrate; and depositing calcite onto the exposed portions of the patterned substrate. | 2022-04-07 |
20220107303 | ON-VEHICLE WATER IN FUEL SENSING SYSTEM AND RELATED SIGNAL PROCESSING - Embodiments herein relate to water in fuel sensing systems that can be mounted on-vehicle. In an embodiment, a water in fuel sensing system is included having a light source, a light detector, and a sensor controller, wherein the sensor controller is in signal communication with the light detector and the sensor controller is configured to evaluate signals received from the light detector, identify water droplets based on the signals received from the light detector, record information regarding the classified water droplets, and generate an estimate of an amount of water in a fuel. Other embodiments are also included herein. | 2022-04-07 |
20220107304 | SEAL ENHANCER - A seal enhancer for improving the patch clamp seal in a patch clamp method or apparatus is provided. The internal solution comprises particular anions and the external solution comprises one or more metal ions at low concentration. | 2022-04-07 |
20220107305 | Companion Diagnostics for NSAIDS and Donepezil for Treating Specific Subpopulations of Patients Suffering from Alzheimer's Disease - The present invention includes a method for identifying a patient response to treatment for Alzheimer's Disease with a non-steroidal anti-inflammatory drug (NSAID) or an acetylcholinesterase (AChE) inhibitor drug comprising: obtaining a blood or serum sample from the patient; determining the presence of a proinflammatory endophenotype in the blood or serum sample of the patient; using the proinflammatory endophenotype to detect treatment response (a responder, a stable, a non-responder or an adverse responder); and treating the patient with the NSAID or the AChE inhibitor if the patient is in the responder or the stable treatment response phenotype group; or preventing a treatment with the NSAID or the AChE inhibitor if the patient is a non-responder or an adverse responder. | 2022-04-07 |
20220107306 | PHOSPHOR-INTEGRATED NANOPARTICLES FOR TARGET SUBSTANCE DETECTION - To provide phosphor-integrated nanoparticles for target substance detection, having improved staining performance for labeling and detecting a target protein at high accuracy. The phosphor-integrated nanoparticles for target substance detection are obtained by surface-modifying phosphor-integrated nanoparticles with a surface modification molecule. The surface modification molecule is at least one kind of surface modification molecule selected from the group consisting of a single-chain antibody containing a heavy chain variable region and an aptamer. | 2022-04-07 |
20220107307 | UTILIZATION OF BLOOD COMPONENT-CONTAINING SOLUTIONS FOR BIOPROSTHETIC VALVE MANUFACTURE AND TESTING - Compositions and methods for testing BHV for performance or longevity are provided. | 2022-04-07 |
20220107308 | IMMUNE CELL TRAPPING DEVICES AND METHODS FOR MAKING AND USING THE SAME - Embodiments herein described provide devices for identifying and collecting rare cells or cells which occur at low frequency in the body of a subject, such as, antigen-specific cells or disease-specific cells. More specifically, the devices are useful for trapping immune cells and the devices contain a physiologically-compatible porous polymer scaffold, a plurality of antigens, and an immune cell-recruiting agent, wherein the plurality of antigens and the immune cell recruiting agent attract and trap the immune cell in the device. Also provided are pharmaceutical compositions, kits, and packages containing such devices. Additional embodiments relate to methods for making the devices, compositions, and kits/packages. Further embodiments relate to methods for using the devices, compositions, and/or kits in the diagnosis or therapy of diseases such as autoimmune diseases or cancers. | 2022-04-07 |
20220107309 | NOVEL BIOTIN-SPECIFIC MONOCLONAL ANTIBODY AND USE THEREOF - The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase. | 2022-04-07 |
20220107310 | NOVEL BIOTIN-SPECIFIC MONOCLONAL ANTIBODY AND USE THEREOF - The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase. | 2022-04-07 |
20220107311 | SYSTEMS AND METHODS FOR BEAD-BASED ASSAYS IN FERROFLUIDS - Some embodiments of the present disclosure are directed to systems and methods for separating, directing, and/or extracting a target molecule from a mix of molecules and may comprise a plurality of non-magnetic beads suspended in a ferro fluid, where the non-magnetic beads may be functionalized with at least one predetermined first molecule configured to bind with a target particle. A microfluidic device may be included which may comprise at least one microfluidic channel, the device configured to dynamically and/or statically receive an amount of the mix. Magnetic field means may be included and may be configured to apply a magnetic field to at least a portion of the at least one channel to exert an indirect force on the non-magnetic heads in the ferro fluid mix, and separate the non-magnetic beads from the ferrofluid. The beads may then be directed to at least one receptor region. At least one outlet may be provided which is arranged to be in communication with the at least one microfluidic channel, the at least one outlet may be configured to receive and extract the separated non-magnetic beads from the ferrofluid. | 2022-04-07 |
20220107312 | IMMUNOCHROMATOGRAPHIC TEST STRIP FOR EXTRACTING AND MEASURING SUGAR CHAIN ANTIGENS, CAPABLE OF CONTROLLING THE DEVELOPMENT OF SPECIMEN BY IMPREGNATING HYDROPHILIC MATERIAL WITH NITRITE OR SOLID ACID REAGENT - The present invention has an object of providing: an immunochromatographic test strip, which controls the development of a specimen on the immunochromatographic test strip and appropriately controls a treatment with an acid reagent and a nitrite, and a neutralizing reagent; and an immunochromatography method using the test strip. The immunochromatographic test strip for extracting and measuring a sugar chain antigen in a specimen comprising: a sample pad to which the specimen mixed with a nitrite or an acid solution is added; a label region comprising a labeled antibody obtained by labeling an antibody against the sugar chain antigen; and a detection region on which an antibody against the sugar chain antigen is immobilized, wherein an antibody-sugar chain antigen-labeled antibody complex is formed in the detection region to measure the sugar chain antigen, and wherein the immunochromatographic test strip has a region impregnated with a neutralizing reagent upstream of the label region, and further has, upstream of the region impregnated with the neutralizing reagent, a region impregnated with a solid acid reagent when the specimen mixed with the nitrite is used, or a region impregnated with the nitrite when the specimen mixed with the acid solution is used, wherein a hydrophilic material is used for the region impregnated with the nitrite or the solid acid reagent. | 2022-04-07 |
20220107313 | IMMUNOCHROMATOGRAPHIC TEST KIT FOR EXTRACTING AND MEASURING SUGAR CHAIN ANTIGENS, CAPABLE OF CONTROLLING ANALYTE DEVELOPMENT - The present invention aims to provide: an immunochromatographic test kit for controlling the development of a specimen on an immunochromatographic test strip and for appropriately controlling a treatment using an acid reagent, a nitrite and a neutralizing reagent; and an immunochromatography method using the kit. The immunochromatographic test kit includes: (i) a nitrite solution or an acid solution; and (ii) an immunochromatographic test strip for extracting and measuring a sugar chain antigen in a specimen, comprising: a sample pad to which a specimen mixed with the nitrite or acid solution is added; a label region comprising a labeled antibody obtained by labeling an antibody against the sugar chain antigen; and a detection region on which an antibody against the sugar chain antigen is immobilized, wherein an antibody-sugar chain antigen-labeled antibody complex is formed in the detection region to measure the sugar chain antigen, and wherein the immunochromatographic test strip has a region impregnated with a neutralizing reagent upstream of the label region, and further has, upstream of the region impregnated with the neutralizing reagent, a region impregnated with a solid acid reagent when the specimen mixed with the nitrite is used, or a region impregnated with the nitrite when the specimen mixed with the acid solution is used, and wherein the nitrite or acid solution comprises one or more selected from the group consisting of polyoxyethylene octyl phenyl ether, a quaternary ammonium compound, phosphoric acid, sodium hydroxide, N-acetyl-L-cysteine, NaCl, PVA, BSA and NaBr. | 2022-04-07 |
20220107314 | IMMUNOASSAY CONTROLS AND THE USE THEREOF - The present invention relates to compositions and methods use in designing immunoassay controls. In various aspects, the invention provides synthetic peptides comprising the sequence CPRRPYIL (SEQ ID NO: 1) or an analog thereof; ELAGLGFAELQC (SEQ ID NO: 4) or an analog thereof; and CDWRKNIDAL (SEQ ID NO: 8) or an analog thereof; specific binding reagents that bind to a CPRRPYIL (SEQ ID NO: 1), ELAGLGFAELQC (SEQ ID NO: 4) or CDWRKNIDAL (SEQ ID NO: 8) peptide; methods of producing such reagents; and assays utilizing such reagents to provide assay controls signals that are unrelated to the measurement of the analyte or analytes of interest in that no reagents used in the analyte assay(s) contribute to the control signal. | 2022-04-07 |
20220107315 | N-ACETYL-D-GLUCOSAMINE FOR ENHANCED SPECIFICITY OF STREP A IMMUNOASSAY - Methods, compositions and kits for detecting Group A | 2022-04-07 |
20220107316 | DETECTION OF HUMAN LEUKOCYTE ANTIGEN-A*32:01 IN CONNECTION WITH DETERMINING DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS) AND METHODS OF TREATING BACTERIAL INFECTION IN A SUBJECT WITH VANCOMYCIN-INDUCED DRESS - Methods of detecting a human leukocyte antigen (HLA)-A*32:01 allele in a subject as disclosed are useful, for example, to determine whether the subject is at risk for developing or has vancomycin-induced drug reaction with eosinophilia and systemic symptoms (DRESS). Methods of treating bacterial infection in a subject with vancomycin-induced DRESS are also disclosed. | 2022-04-07 |
20220107317 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING CORONAVIRUS DISEASE 2019 - Provided are methods and compositions for the diagnosis and treatment of COVID-19, a disease caused by SARS-CoV-2 infection. More specifically, peptides that bind to SARS-CoV-2 are provided for use as diagnostic and therapeutic compositions in diagnosis, treatment and prevention of individuals contracting, or in danger of contracting COVID-19. | 2022-04-07 |
20220107318 | IMMUNOASSAY METHOD FOR FREE AIM IN BIOLOGICAL SAMPLE, AND ASSAY KIT - A problem to be solved is to improve the specificity of an anti-AIM antibody for free AIM in a biological sample containing complex AIM and free AIM. | 2022-04-07 |
20220107319 | SYSTEMS AND METHODS FOR THE MOLECULAR QUANTIFICATION OF SKIN DAMAGE IN SKIN - Systems and methods for quantifying skin damage, such as oxidative skin damage from sun exposure, are disclosed herein. The skin damage can be quantified using by using a proximity-based assay that measures a skin marker, such as peptide 3R. The quantitative data can be advantageously used to serve, for example, as markers of overall dermatologic health, risk stratification factors, markers for the presence of dermatologic conditions, including clinical disease, predictors of subclinical and/or minimal residual disease presence, determinants of treatment response and disease progression, and prognosticators of patient outcome. | 2022-04-07 |
20220107320 | Assaying Bladder-Associated Samples, Identifying and Treating Bladder-Associated Neoplasia, and Kits for Use Therein - Methods are provided for assaying bladder-associated samples. Aspects of the methods include detecting per cell programmed-death ligand 1 (PD-L1) expression in a bladder-associated sample. In some instances, the methods include detecting whether an immune cell that expresses PD-Ll above a predetermined threshold is present in a bladder-associated sample and/or detecting a PD-L1-aneuploid-to-PD-L1-epithelial ratio of a bladder-associated sample. Aspects of the methods may also include identifying whether a malignant bladder-associated neoplasia is present. Methods are also provided for treating a subject for a malignant bladder-associated neoplasia, wherein aspects of such methods include administering a therapeutic to a subject having an identified malignant bladder-associated neoplasia. In addition, kits that find use in practicing the subject methods are also provided. | 2022-04-07 |
20220107321 | Cancer Progression Risk Assessment by Microvascular Phenotype - Repression of CD36 vasculature in stromal tissues surrounding a pre-cancerous lesion provides is indicative of increased risk of subsequent progression to invasive cancer. Methods of assessing progression risk by measuring the abundance of CD36 vasculature in stromal tissues surrounding a precancerous lesion are provided, useful for various cancer types, including for assessing the risk of DCIS progression to breast cancer. Immunohistochemical analysis methods and diagnostic thresholds are provided, as well as associated methods of treatment and diagnostic kits. | 2022-04-07 |
20220107322 | LIPID, PROTEIN, AND METABOLITE MARKERS FOR THE DIAGNOSIS AND TREATMENT OF PROSTATE CANCER - Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including the detection of levels of a variety of biomarkers diagnostic of prostate cancer. The invention also provides methods of treating prostate cancer by administering a biomarker or an agent that modulates a biomarker of prostate cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided. | 2022-04-07 |
20220107323 | METHODS AND COMPOSITIONS FOR IDENTIFYING WHETHER A SUBJECT SUFFERING FROM A CANCER WILL ACHIEVE A RESPONSE WITH AN IMMUNE-CHECKPOINT INHIBITOR - The present invention relates to use of soluble CD27 as a biomarker to predict the response to an immune checkpoint inhibitor treatment. Inventors have worked with two cohorts of patients and have identified a soluble marker, CD27, present in the plasma of patients with renal cell cancer whose pre-treatment concentrations predict the response to anti-PD-1/PD-L1. This marker appears more as a predictive marker of response to anti-PD1/PD-L1 treatment, than as a prognostic marker. Indeed, it is not associated with better survival in patients with metastatic renal cell cancer treated with an antiangiogenic agent. This marker is not correlated with conventional clinical markers of severity that classify patients with metastatic renal cancer. | 2022-04-07 |
20220107324 | PERIPHERAL BLOOD BIOMARKER FOR EVALUATING ANTI-TUMOR IMMUNE EFFECT OF RADIATION THERAPY - Provided is a peripheral blood biomarker for evaluating the antitumor immune effect of radiation therapy. Also provided is a method in which the composition of cell subpopulation in a sample obtained from a subject is used as an index for immune activation in the subject caused by a radiation therapy. By comparing, with a reference, the amount of CD4 | 2022-04-07 |
20220107325 | SULFONATED 2(7)-AMINOACRIDONE AND 1-AMINOPYRENE DYES AND THEIR USE AS FLUORESCENT TAGS, IN PARTICULAR FOR CARBOHYDRATE ANALYSIS - Sulfonated 2(7)-aminoacridone and 1-aminopyrene dyes and their use as fluorescent tags, in particular for carbohydrate analysis The invention relates to fluorescent dyes with multiple negatively charged groups in their ionized form which are aminoacridone sulfonamides or 1-aminopyrenes having of one of the following general formulae A-D: Formula (A), Formula (B), Formula (C), Formula (D), wherein the ionizable groups X are typically selected from the following: SH, COOH, SO | 2022-04-07 |
20220107326 | METHODS FOR CHARACTERIZING AND ENGINEERING PROTEIN-PROTEIN INTERACTIONS - Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications. | 2022-04-07 |
20220107327 | MULTI-TARGET CROSSLINKERS AND USES THEREOF - Disclosed herein, inter alia, are compositions and methods for cross-linking biomolecules. In an aspect is provided a method of detecting a covalently conjugated molecule, the method including i) contacting a first biomolecule and a second biomolecule with a crosslinking agent to form a covalently conjugated biomolecule; ii) identifying a first point of attachment of the crosslinking agent to the first biomolecule using mass spectroscopy; and iii) identifying a second point of attachment of the crosslinking agent to the second biomolecule using mass spectroscopy; thereby detecting a covalently conjugated molecule. | 2022-04-07 |
20220107328 | METHODS OF TREATING LIVER DISEASES - Provided herein are methods and compositions for the treating a patient with one or more conditions associated with PNPLA3, such as nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and/or alcoholic liver disease (ALD). Methods and compositions are also provided for modulating the expression of the PNPLA3 gene in a cell by altering gene signaling networks. Companion diagnostic methods, compositions and kits are also provided. | 2022-04-07 |
20220107329 | METHODS OF DETECTING AND DIAGNOSING DEFECTS OF THE LYMPHATIC VASCULATURE - Disclosed herein are methods and compositions useful for identifying and treating diseases, conditions, and abnormalities of the lymphatic vasculature. In some embodiments, the methods include determining a level of platelet factor 4 (PF4) in a biological sample of the subject, and diagnosing the subject as having a disease or condition of the lymphatic vasculature if the subject's PF4 level is increased compared to a control PF4 level. Also disclosed herein are method of treating a subject having an increased PF4 level. In some embodiments, the methods include administering a composition comprising a molecule that specifically binds to and inhibits the function of PF4, such as, for example, an antibody. In some embodiments, the subject has previously been diagnosed with obesity. | 2022-04-07 |
20220107330 | CARTRIDGES FOR IMMUNOASSAY TESTS AND METHODS OF USING THE SAME - This invention relates to an apparatus for conducting immunoassay test. The apparatus includes a groove unit having a groove along a vertical direction configured to hold a rod-shaped portion of a probe along the vertical direction, and a push pin configured to move along a horizontal direction, the push pin being capable of residing at a first position and a second position. A tip of the push pin is capable of pressing the rod-shaped portion of the probe against the groove when the push pin resides at the first position. The distance between the tip of the push pin and the groove is larger than a diameter of the rod-shaped portion of the probe when the push pin resides at the second position. | 2022-04-07 |
20220107331 | METHOD FOR DETERMINING AT LEAST ONE STATE OF AT LEAST ONE CAVITY OF A TRANSPORT INTERFACE CONFIGURED FOR TRANSPORTING SAMPLE TUBES - A method for determining at least one state of at least one cavity of a transport interface configured for transporting sample tubes is provided and comprises: capturing at least one image of at least a part of the transport interface by using at least one camera; categorizing the state of the cavity into at least one category by applying at least one trained model on the image by using at least one processing unit, wherein the trained model is being trained on image data of the transport interface, wherein the image data comprises a plurality of images of the transport interface with cavities in different states; and providing the determined category of at least one cavity via at least one communication interface. | 2022-04-07 |
20220107332 | A REMOTE CONTROL METHOD OF SAMPLE PREPARATION AND/OR SAMPLE ANALYSIS - The present invention provides a remote control method of sample preparation and/or sample analysis, which is characterized by synchronously operating a control apparatus in a guest system comprising a sample preparation apparatus and/or sample analysis apparatus through a host computer installed with a remote control software in a host system when the control apparatus in the host system is operated, therefore the sample preparation apparatus and/or sample analysis apparatus can be performed through the synchronously operated control apparatus in the guest system. | 2022-04-07 |
20220107333 | SAMPLE ANALYSIS SYSTEM AND SAMPLE ANALYSIS METHOD - Sample analysis system and method are provided. The sample analysis system includes a first sample analyzer, a second sample analyzer, a sample rack transport device, and a sample sorting device provided between the first and second sample analyzers. The sample rack transport device includes a transport track for conveying a sample rack with sample containers to the first and/or second sample analyzer for testing. The first and second sample analyzers are arranged in sequence along a first transport direction of the transport track. The sample sorting device includes a connecting track, a sorting platform, and a sample transfer mechanism. The sample transfer mechanism is capable of moving to a position above the connecting track, so as to transfer the sample container(s) in the sample rack conveyed to the connecting track to a sample rack on the sorting platform. Efficiency of sample analysis is improved. | 2022-04-07 |
20220107334 | AUTOSAMPLER - An autosampler for dispensing samples is provided. The autosampler comprises a sample tray for holding the samples to be dispensed. The sample tray is moveable between a plurality of dispensing positions. The autosampler also comprises a noncontact coupling configured to move the sample tray between the plurality of dispensing positions. An autosampler for dispensing samples is also provided, comprising: a sample tray for holding the samples to be dispensed, the sample tray being moveable between a plurality of dispensing positions, the sample tray and a body of the autosampler comprising respective contact surfaces that contact each other as the sample tray moves between the plurality of dispensing positions, wherein the contact surface of at least one of the sample tray and the body of the autosampler comprises a self-lubricating material. | 2022-04-07 |
20220107335 | ENGINE SPEED AND POSITION DETECTION - One or more techniques and/or systems are disclosed for identifying a position of an engine, such as the position of the pistons, camshaft, and/or crank shaft, during engine starting. In some implementations, a magnetic reluctance sensor can detect the reluctance from a proximate timing gear, resulting in an input voltage signal indicative of the detected reluctance. The input voltage signal can be converted to a digital voltage signal. A trigger threshold can set to identify a detection window. During the detection window, a zero-cross of the input voltage signal is detected to identify an engine position, and any other zero-crossing signals are not identified, thereby mitigating the effects of noise at the slow starting speeds. | 2022-04-07 |
20220107336 | MAGNETIC-FIELD SENSOR DEVICE - A magnetic-field sensor device includes at least two impulse wires, a coil assembly which radially surrounds the at least two impulse wires, the coil assembly defining a sensor element and a feedback element which generates an auxiliary magnetic field, an energy storage which is electrically connected to the coil assembly, a switching element which is electrically connected to the energy storage and to the feedback element, and a control unit which electrically controls the switching element. | 2022-04-07 |