17th week of 2013 patent applcation highlights part 43 |
Patent application number | Title | Published |
20130101961 | DENTAL IMPLANT WITH ANTIROTATIONAL COG - A one-piece dental implant for placement into bone, the one-piece dental implant extending between a coronal end and an apical end, and the one-piece dental implant having a threaded shaft tapering to a point at the apical end, wherein the threaded shaft has a series of self-tapping cutting threads, a collar having at least one ring with a path that includes a diversion, and an anti-rotational cog traversing a plurality of said the threads. Also, disclosed is a non-surgical method of placing a dental implant by providing the dental implant, providing a starting bore through a patient's gum into said patient's jaw bone, and threading the dental implant through the starting bore into the patient's jaw bone. | 2013-04-25 |
20130101962 | DENTURE AND METHOD AND APPARATUS OF MAKING SAME - A method for making a denture comprising a base and a plurality of teeth joined thereto. The method comprises forming a first cavity in a block of a denture base material, the first cavity being formed to match the contour of natural teeth as arranged on maxillae or on a mandible; filling the first cavity with a first fluid synthetic tooth material and solidifying the first fluid synthetic tooth material into a first solid synthetic tooth material; removing a portion of the first solid synthetic tooth material to form the plurality of teeth; and removing a portion of the block of denture base material to form the denture base. The steps of the method may be implemented by a computer. An apparatus for making the denture according to certain embodiments of the method, and a denture comprised of a base and artificial teeth are also disclosed. | 2013-04-25 |
20130101963 | RECHARGEABLE LONG-TERM ANTIFUNGAL DENTURE MATERIALS - Polymers and copolymers including a functional polymer component may be used as conventional denture materials. Antifungal materials may be releasably bound to the functional polymer component such that the antifungal materials may be slowly eluted over an extended period of time to combat a fungal infection. | 2013-04-25 |
20130101964 | IMPRESSION GINGIVAL CUFF FOR DENTAL IMPLANTS - An impression gingival cuff for taking an impression during a restoration procedure of a dental implant osteointegrated in a jaw bone. The dental implant is engageably connectable with an abutment having a prominent countour. The impression gingival cuff has a tubular-conical shape, a circumferential thin wall, two open ends including an apical end oriented towards a tooth root and a proximal end oriented towards an occlusal direction, an inner surface oriented towards the abutment and an outer surface oriented towards surrounding gingival tissue. During installation of the cuff between the dental implant and the abutment, the apical end retains the prominent contour of the abutment so that the outer surface of the cuff pushes the surrounding gingival tissue away from the abutment. This allows taking an accurate impression of both the dental implant and abutment in order to fabricate a high precision restoration. | 2013-04-25 |
20130101965 | TOOTHBRUSH WITH REACTIVE COMPOSITION FOR REMINERALIZATION OF TEETH - A toothbrush having brush means and a means to support the brush means; and a one or two part therapeutic tooth treatment composition which becomes activated when wet incorporated on the brush means or within the toothbrush means to support the brush means in a manner such that the composition remains inactive during storage and is only activated when contacted with water or saliva; and a method comprising brushing a tooth with the toothbrush so that the brush means become wet with saliva, optionally wetting the brush means with water immediately prior to brushing a tooth, and the composition becomes activated to form a therapeutic composition to provide remineralization, whitening, and/or fluoridation. | 2013-04-25 |
20130101966 | ORAL HEALTH INDEX - Methods of measuring a subject's Ayurvedic oral health are disclosed. The methods include examining the subject and assigning a health score for each of one or more Ayurvedic oral health parameters. The scores can be used to compare the Ayurvedic oral health of different populations, to assess changes in a subject's Ayurvedic oral health, and to assess the efficacy of Ayurvedic treatments. | 2013-04-25 |
20130101967 | AQUEOUS COMPOSITION SUITABLE FOR INTRA-ORAL SCANNING METHODS - Presently described are methods of intra-oral scanning and an aqueous dental compositions suitable for use for scanning comprising an aqueous solution of a polymer, wherein the solution increases in viscosity from ambient temperature to body temperature; and diffuse reflective particles having an average particle size of at least about 1 micron. | 2013-04-25 |
20130101968 | HEAVY EQUIPMENT SIMULATOR AND RELATED METHODS - A method for training an operator of a machine including interacting with a simulation mode of a heavy equipment model simulator and evaluating an operator using criteria substantially similar to an original equipment manufacturer (OEM) criteria for a non-simulated heavy equipment model. Interacting includes performing one or more simulated exercises substantially similar to an OEM exercise for the non-simulated heavy equipment model. | 2013-04-25 |
20130101969 | METHODS AND APPARATUS FOR MONITORING AND ENCOURAGING HEALTH AND FITNESS - Methods and apparatus are provided for monitoring and encouraging health and fitness. In accordance with a first aspect, an apparatus is provided that is adapted to assist in weight loss and exercise. The apparatus comprises a personal digital assistant (PDA) having computer program code adapted to assist in at least one of calorie counting, meal selection, meal suggestion, weight monitoring, weight loss or gain monitoring, fat consumption monitoring, sugar consumption monitoring and salt consumption monitoring. The PDA also includes computer program code adapted to display historical data regarding at least one of calorie counting, meal selection, meal suggestion, weight monitoring, weight loss or gain monitoring, fat consumption monitoring, sugar consumption monitoring and salt consumption monitoring. Numerous other embodiments are provided, as are methods, systems and computer program products. | 2013-04-25 |
20130101970 | SYSTEM AND METHOD FOR USING PSYCHOLOGICAL SIGNIFICANCE PATTERN INFORMATION FOR MATCHING WITH TARGET INFORMATION - A computer-implemented system for creating a classification significance pattern for end users, and enabling end users to use their classification significance pattern to conduct custom searches for target information, such as books, other textual content, information about products, services, and jobs, as well as enabling third parties, such as vendors and potential employers, to target their advertisements to groups of users meeting a certain classification. A classification significance pattern is created by having a user take a psychological test, for example, that includes a personality test, a design taste test, a recreation/travel test, a life satisfaction test, an interactive game module, or a career/job test, and having the system automatically score such test and classifying the user based on a defined abstract classification. | 2013-04-25 |
20130101971 | Motor Coordination Testing Device - A motor coordination testing device is disclosed. The motor coordination testing device includes a signal generator and a signal retrieving device. The signal generator includes a first electronic protractor and a first support rotatably coupled with the first electronic protractor. The signal retrieving device is electrically connected to the signal generator. | 2013-04-25 |
20130101972 | METHODS FOR REDUCING RISK - Methods for limiting and controlling the distribution of dronedarone to patients whose use of the drug might present an unacceptable risk. | 2013-04-25 |
20130101973 | SIMULATED TISSUE STRUCTURE FOR SURGICAL TRAINING - A simulated tissue structure for practicing surgical techniques is provided. In particular, a realistic organ model or tissue portion for practicing the removal of a tumor or other undesired tissue followed by suturing a remnant defect as part of the same surgical procedure is provided. The simulated tissue structure includes an artificial tumor disposed between layers of elastomeric material and mounted on a simulated organ wall or tissue portion. The simulated tissue structure is modular and interchangeable. At least one of the layers includes a mesh reinforcement. A defect comprising two juxtapositioned surfaces defining a gap between the surfaces is created in the simulated tissue structure and the trainee practices tumor removal and closure of the gap by suturing in a laparoscopic environment. | 2013-04-25 |
20130101974 | SYSTEM AND METHOD FOR WIRELESS ASSESSMENT ADMINISTRATION AND DATA COLLECTION - A portable storage apparatus is configured to interface with a computer having a processor. The portable storage apparatus comprises a wireless transceiver for transmitting and receiving data, an operating system, and a memory containing data representing a plurality of questions. The portable storage apparatus is configured to receive data representative of a question identification number, to communicate a question, from the plurality of questions, corresponding to the question identification number, to receive data representative of a response to the question, and to transmit the data representative of the response. | 2013-04-25 |
20130101975 | System and Method for Targeting Specific Benefits with Cognitive Training - The disclosure is directed to methods for enhancing cognition in a participant by dynamically constructing a cognitive training regime to exercise desired benefits. Additionally, computer implemented methods for enhancing cognition in a participant by dynamically constructing a cognitive training regime to exercise desired benefits are also provided. The methods and systems disclosed include the use or implementation of computer comprising: a processor; and a memory coupled to the processor, the memory comprising computer-executable instructions that when executed by the processor perform operations including: dynamically constructing a cognitive training regime to exercise desired benefits. | 2013-04-25 |
20130101976 | Cognitive assessment and treatment platform utilizing a distributed tangible-graphical user interface device - A cognitive disorder diagnostic and treatment system that employs cognitive cubes, gameplay associated with the cognitive cubes, and a data gathering as statistical analysis base device that may be a computer, that communicates the gathered data to a web server host according to a unique ID associated with particular cognitive cubes and further associated with a particular player. Using the statistical data gathered using the gameplay, various cognitive disorders may be successfully diagnosed and treated with higher reliability. | 2013-04-25 |
20130101977 | METHOD AND SYSTEM FOR PROVIDING EDUCATION CONTENTS - A method and an apparatus of providing education contents are provided. The method includes transmitting education contents to a display device in response to an education contents request received from the display device, receiving, from a personal device, a personal request that is associated with the education contents and comprises an education contents identifier of the education contents, generating a personal response to the personal request received from the personal device and transmitting the generated personal response to the personal device. | 2013-04-25 |
20130101978 | System and computer program product for developing and delivering a training course - A first processing component is configured to create at least a first slide from electronic media selected from an electronic media repository. A computer communications interface is configured to access via a computer network a training electronic media repository. A first user interface is configured to permit selecting from the training electronic media repository a training course that includes at least a first slide including a presenter screen and further including at least a first presentee screen. A second processing component is configured to generate an image of the at least first slide for display by a first display subsystem. A third processing component is configured to generate an image, of the at least first presentee screen for display by a second display subsystem to at least one presentee without displaying the presenter screen to the presentee. | 2013-04-25 |
20130101979 | Dry-Erase Board with Inserts - A new design for a dry-erase board allows for writing on a clear top surface or a second surface under the clear top surface. The dry-erase board includes an insert positioned between the clear top surface and a second surface, the insert being protected by the clear top surface | 2013-04-25 |
20130101980 | METHOD AND APPARATUS FOR FORMING A WRITABLE ERASABLE AREA ON AN OBJECT - A method of forming a writable erasable area on an object includes selecting a glass sheet having a front surface and a back surface, where the front surface is opposed to and parallel to the back surface. An area of the object where the writable erasable area is to be located is selected. The selected area has a select non-flat shape. The shape of the glass sheet is conformed to the select non-flat shape. The glass sheet is then mounted on the object such that the glass sheet is located at the selected area of the object and conforms in shape to the selected area of the object. | 2013-04-25 |
20130101981 | PARTICLE MATRIX FOR STORAGE OF BIOMOLECULES - Matrices for manipulation of biopolymers, including the separation, purification, immobilization and archival storage of biopolymers is disclosed. | 2013-04-25 |
20130101982 | FLUID MIXING SYSTEMS WITH ADJUSTABLE MIXING ELEMENT - A fluid mixing system includes a support housing having an interior surface bounding a chamber. A flexible bag is disposed within the chamber of the support housing, the flexible bag having an interior surface bounding a compartment. An impeller is disposed within the chamber of the flexible bag. A drive shaft is coupled with the impeller such that rotation of the drive shaft facilitates rotation of the impeller. A drive motor assembly is coupled with the draft shaft and is adapted to rotate the drive shaft. An adjustable arm assembly is coupled with the drive motor assembly and is adapted to move the drive motor assembly which in turn moves the position of the drive shaft and impeller. An electrical controller can control movement of the adjustable arm. | 2013-04-25 |
20130101983 | NON CONTACT REAL TIME MICRO POLYMERASE CHAIN REACTION SYSTEM AND METHOD THEREOF - The present disclosure provides a non contact real time micro Polymerase Chain Reaction [PCR] system comprises; a chip having a reaction chamber for holding a sample and an embedded metal heater below the reaction chamber for heating the sample; an optical unit comprising associated LED driver and photo detector amplifier placed above the chip to detect the fluorescence; an induction heater mounted around the chip and is inductively coupled to the metal heater; an infrared temperature sensor mounted below the chip for measuring a temperature of the metal heater, wherein said infrared temperature sensor is interfaced with a signal conditioner; and a controller interfaced with the signal conditioner and the induction heater for regulating the power to the induction heater based on feedback received from the infrared temperature sensor through the signal conditioner. | 2013-04-25 |
20130101984 | METHODS OF DETECTING SLEEPINESS - The present application is directed to methods of detecting sleepiness. | 2013-04-25 |
20130101985 | METHODS FOR THE DETECTION OF JC POLYOMA VIRUS - Methods and compositions for determining whether a subject is at risk for PML, including subjects being treated with immunosuppressants, by determining whether the subject harbors a JCV variant with reduced binding for sialic acid relative to a normal JCV, are presented. Furthermore, combinations of JCV-VP1 sequence variations that are associated with PML and that can be used as a basis of an assay for identifying subjects susceptible to PML, subjects with PML (e.g., early stage PML), or subjects at risk of developing PML in response to an immunosuppressive treatment are provided. | 2013-04-25 |
20130101986 | In Vitro Method for obtaining Intrahepatic Fibroblasts Infected with Hepatitis C Virus - The present invention relates to in vitro methods for obtaining intrahepatic fibroblasts infected with hepatitis C virus, to the infected intrahepatic fibroblasts obtained by means of these methods, and also to methods for screening for anti-fibrogenesis molecules and for anti-HCV molecules using these cells. | 2013-04-25 |
20130101987 | Detection of feline Immunodeficiency Virus - Method, device and kit for the detection of antibodies directed to Feline Immunodeficiency Virus (FIV). The method includes contacting the felid biological sample with FIV env polypeptide and detecting whether the polypeptide substantially binds to the antibody in the biological sample. The method will detect FIV antibodies in a sample from animals that have been naturally infected but the method will not detect antibodies in a sample from animals that have not been infected and that have not been vaccinated with an FIV vaccine after within about the previous five to eight weeks. | 2013-04-25 |
20130101988 | COMPOSITIONS, METHODS AND KITS TO DETECT HERPES SIMPLEX VIRUS NUCLEIC ACIDS - The disclosed invention is related to methods, compositions, kits and isolated nucleic acid sequences for targeting Herpes Simplex Virus (HSV) nucleic acid (eg. HSV-1 and/or HSV-2 nucleic acid). Compositions include amplification oligomers, detection probe oligomers and/or target capture oligomers. Kits and methods comprise at least one of these oligomers. | 2013-04-25 |
20130101989 | Diagnostic Method for Predicting the Response of a Patient to Chemovirotherapy or Radiovirotherapy - Described is a diagnostic method for predicting the response of a patient to chemovirotherapy or radiovirotherapy, comprising exposing primary tumor cells from a patient, e.g., tumor cells obtained from a brain tumor or pancreatic cancer, to (i) a parvovirus and/or (ii) a chemotherapeutic agent or radiotherapy, and determining the reduction of the expression or concentration of ISG15. | 2013-04-25 |
20130101990 | MICROFLUIDIC SYSTEM FOR AMPLIFYING AND DETECTING POLYNUCLEOTIDES IN PARALLEL - The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept a plurality of samples, and which can carry out PCR on each sample individually, or a group of, or all of the plurality of samples simultaneously. | 2013-04-25 |
20130101991 | MICROFLUIDIC ASSAY IN IDEALIZED MICROVASCULAR NETWORK FOR SELECTION AND OPTIMIZATION OF DRUG DELIVERY VEHICLES TO SIMULATED TUMORS - An apparatus for assaying a tumor drug delivery vehicle and or drug can include an idealized microvascular network (IMN) of one or more interconnected idealized flow channels in fluid communication through a porous wall with a tissue space (e.g., idealized tissue space) containing animal cells and means for quantifying drug delivery through the IMN to the animal cells. | 2013-04-25 |
20130101992 | Diagnostic Assay For Type 1 Diabetes - There is an association between enteroviruses and type 1 diabetes (T1D). The present invention is based on the finding that particular enterovirus serotypes are T1D risk serotypes, while others are protective against the disease. The present invention relates to a diagnostic assay for type 1 diabetes (T1D), and especially to an assay for predicting the risk of contracting the disease. It also relates to a method of monitoring the efficacy of antiviral treatments aiming at prevention of T1D. The invention still further relates to a diagnostic kit. | 2013-04-25 |
20130101993 | MICROCHEMICAL CHIP, PRODUCING METHOD THEREOF AND METHOD FOR USING THE MICROCHEMICAL CHIP - According to the microchemical chip of the present invention, the sample introducing port | 2013-04-25 |
20130101994 | Method of Analysing a Cell or Other Biological Material Containing a Nucleic Acid - According to the invention there is provided a compound of Formula (I) in which: A is a C | 2013-04-25 |
20130101995 | DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT - The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid. | 2013-04-25 |
20130101996 | DETECTION METHOD AND APPARATUS OF ACTIVATED NEUTROPHILS - To provide a detection method of activated neutrophils enabling the classification of normal leukocytes and the detection of activated neutrophils, a measurement sample in which erythrocytes in a biotic sample are hemolyzed and nucleic acid of leukocytes is stained by a nucleic acid staining fluorochrome is prepared, the sample is irradiated with light, and leukocytes in the biotic sample are classified into at least a cluster containing neutrophils and a cluster containing eosinophils based on scattered light intensity and fluorescence intensity obtained by measuring the scattered light intensity and fluorescence intensity generated from particles in the sample to detect particles present between the cluster containing neutrophils and the cluster containing eosinophils as activated neutrophils. | 2013-04-25 |
20130101997 | GENETIC MARKER FOR THE DIAGNOSIS OF DEMENTIA WITH LEWY BODIES - Specific alterations in BChE gene have been found which allow determining whether a patient suffers from dementia with Lewy bodies (DLB), and allow distinguishing it from Alzheimer's disease. The invention provides an in vitro method for the diagnosis of DLB comprising determining in a biological sample from a subject, the genotype of the following alterations in butyrylcholinesterase (BChE) gene: the polymorphic sites at position 68974 in NCBI Accession Number NG_009031 (i.e. position 934 in SEQ ID NO: 28), and the polymorphic sites 3687, 4206, 4443, and the poly-thymine region at positions 4780 to 4786, said positions with reference to NCBI Accession Number NG_009031 (i.e. positions 3687, 4206 and 4443 respectively in SEQ ID NO: 1), which corresponds to the nucleotide sequence of human BChE gene. | 2013-04-25 |
20130101998 | METHOD FOR DIAGNOSING KIDNEY DISEASE COMPRISING DETECTING THE LEVEL OF ANNEXIN A2 OR S100A6 - The present invention provides biomarkers for detecting kidney disease, selected from the oligonucleotide sequence, complementary sequence or derivatives, amino acid sequence or derivatives, fragment, variants, antibody of annexin A2 or S100A6 or combinations thereof. Moreover, the present invention also provides an assay kit and a method for kidney disease detecting, practically for the kidney disease resulting from acute tubular necrosis. | 2013-04-25 |
20130101999 | MULTI-LEG LUMINESCENT NANOPARTICLES, MULTI-LEG LUMINESCENT NANOPARTICLE COMPOUNDS AND VARIOUS APPLICATIONS - Multi-leg luminescent nanoparticles (“MLN's”) that can be paired to other MLN's as well s biological molecules to film branched multi-leg luminescent nanoparticles (“BMLN's) that can be used in biological multiplexing applications, imaging applications, biological detection applications and other biological applications. | 2013-04-25 |
20130102000 | PEPTIDE NUCLEIC ACID PROBE, KIT AND METHOD FOR DETECTION AND/OR QUANTIFICATION OF SALMONELLA SPP. AND APPLICATIONS THEREOF - The present invention refers to the development of a Peptide Nucleic acid (PNA) probe for the detection of the | 2013-04-25 |
20130102001 | METHOD TO DETERMINE ZYGOSITY OF THE FAD2 GENE IN CANOLA USING END-POINT TAQMAN PCR - The subject disclosure relates in part to endpoint TaqMan® PCR assays for the detection and high throughput zygosity analysis of the fad-2 gene in canola. The subject disclosure further relates, in part, to the use of wild type DNA as a reference for use in determining zygosity. These and other related procedures can be used to uniquely identify the zygosity and variety of canola lines comprising the subject gene. The subject disclosure also provides related kits for determining zygosity from a sample of a canola plant or seed, for example. | 2013-04-25 |
20130102002 | METHOD TO DETERMINE ZYGOSITY OF THE FAD3 GENE IN CANOLA USING END-POINT TAQMAN.RTM. PCR - The subject disclosure relates in part to endpoint TaqMan® PCR assays for the detection and high throughput zygosity analysis of the fad-3c gene in canola. The subject disclosure further relates, in part, to the use of wild type DNA as a reference for use in determining zygosity. These and other related procedures can be used to uniquely identify the zygosity and variety of canola lines comprising the subject gene. The subject disclosure also provides related kits for determining zygosity from a sample of a canola plant or seed, for example. | 2013-04-25 |
20130102003 | Point-of-Care Immunoassay for Quantitative Small Analyte Detection - Point-of-care assays for quantitatively measuring the amount of small analytes, such as opioids, tetrahydrocannibinol (“THC”), or hormones, in a biological sample are disclosed. The assays are capable of non-competitive detection of a small analyte using binding agents that selectively bind the analyte and capture agents that selectively bind a complex of the binding agent and analyte but do not bind either free binding agent or free analyte. The assay is capable of simultaneous diction of multiple analytes for multiplex analysis and quantitative control. Quantitative measurements are obtained by plotting results against a response surface calculated from a plurality of analyte standards and adjusted using internal controls. | 2013-04-25 |
20130102004 | Endometrial Phase or Endometrial Cancer Biomarkers - Methods for detecting endometrial diseases or an endometrium phase in a subject are described comprising measuring endometrial markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for endometrial diseases, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for endometrial diseases employing endometrial markers, polynucleotides encoding the markers, and/or binding agents for the markers. | 2013-04-25 |
20130102005 | INHIBITOR LEACHING RESISTANT NUCLEIC ACID STORAGE REAGENT - The invention provides compositions and methods related to a nucleic acid storage reagent. | 2013-04-25 |
20130102006 | DETECTION METHOD FOR NOVEL ROS1 FUSIONS - Polynucleotides which are novel causative genes for cancer are elucidated, and a detection method of the polynucleotides or polypeptides encoded by the polynucleotides, and a kit and a primer set for detection are provided, based on the knowledge gained by the elucidation. In the detection method, a fusion gene comprising part of an SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 gene and part of a ROS1 gene, or a fusion protein encoded by the fusion gene is detected. The primer set or the detection kit comprises a sense primer designed based on a portion encoding SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 and an antisense primer designed based on a portion encoding ROS1. | 2013-04-25 |
20130102007 | COMPOSITIONS AND METHODS FOR CHARACTERIZING AND REGULATING OLFACTORY SENSATION - The present invention relates to the characterization of odorant receptors. In particular, the present invention relates to the OR7D4 proteins and nucleic acids encoding OR7D4 proteins and cell systems for screening for modulators of OR7D4 receptors. The present invention further provides assays for the detection of OR7D4 polymorphisms and mutations associated with altered olfactory sensation states, as well as methods of screening for therapeutic agents, ligands, and modulators of OR7D4 receptors. | 2013-04-25 |
20130102008 | Method for Screening for S1P Lyase Inhibitors Using Cultured Cells - To provide a method for screening using cultured cells, intended to find a compound which increases the amount of sphingosine-1-phosphate or dihydrosphingosine-1-phosphate by SPL inhibitory activity rapidly, simply and highly sensitively. Provided are: a rapid and simple measurement method employing a scintillation proximity assay (SPA); a method with greatly improved detection sensitivity to the activity of a compound by controlling the concentration of the vitamin B | 2013-04-25 |
20130102009 | SIRTUIN ACTIVATORS AND ACTIVATION ASSAYS - Provided are methods and compositions for detecting a compound that activates a sirtuin deacetylase activity on a fluorescent-free activation substrate in vitro. Further provided are sirtuin modulating compounds of the formulas (I)-(XXI), and related compounds (XXXI), (XXXII), (XXXIII), and (XXXIV), including the fluorescent free-substrate SIRT1 activator compounds of formulas (XL), (XI), (XII), and (XIII). | 2013-04-25 |
20130102010 | T1R Hetero-Oligomeric Taste Receptors and Cell Lines That Express Said Receptors and Use Thereof for Identification of Taste Compounds - The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. | 2013-04-25 |
20130102011 | HUMAN LEUCINE-RICH A-2-GLYCOPROTEIN-1 AND AMINOPEPTIDASE N AS RISK INDICATORS FOR CANCER - Diagnostic tests for characterizing a test subject's risk of developing or having cancer, based on determining the level of LRG1 and/or CD13 in a bodily sample obtained from a test subject are described. Levels of LRG1 and/or CD13 are then compared to a predetermined value that is derived from measurements of the levels of LRG1 and/or CD13 in comparable bodily samples obtained from control subjects. Such comparison characterizes the test subject's risk of developing or having cancer. | 2013-04-25 |
20130102012 | FLUORESCENT-LABELLED DIUBIQUITIN SUBSTRATE FOR A DEUBIQUITINASE ASSAY - The application relates to a substrate for measuring the activity of a deubiquitinating enzyme (DUB), comprising a diubiquitin molecule, wherein an ubiquitin monomer is labeled with a fluorescent label, as well as an assay for DUB enzymes using such substrates. | 2013-04-25 |
20130102013 | MATERIALS AND METHODS TO DETECT PYRIMIDINE-PYRIMIDINE DIMER FORMATION - Disclosed are methods and apparatuses pertaining to measuring DNA damage due to exposure to ultraviolet light, as measured by formation of pyrimidine-pyrimidine dimers in a polynucleotide. The apparatuses can be in the form of a patch which can be particularly useful in measuring the effectiveness of a sunscreen. The apparatuses can further include a reporter agent for instant determination of the pyrimidine-pyrimidine dimer formation. | 2013-04-25 |
20130102014 | FLUORINATED RESORUFIN COMPOUNDS AND THEIR APPLICATION - The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats. | 2013-04-25 |
20130102015 | COMPOSITION FOR THE DETERMINATION OF COAGULATION CHARACTERISTICS OF A TEST LIQUID - The present invention is directed to a diagnostic composition for use in the viscoelastic analysis of a test liquid, and to a container ( | 2013-04-25 |
20130102016 | Glucose Dehydrogenase - A modified pyrroloquinoline quinone glucose dehydrogenase that exhibits a high selectivity for glucose is provided. A modified pyrroloquinoline quinone glucose dehydrogenase is disclosed in which the amino acid residue G at Position 99 of a pyrroloquinoline quinone glucose dehydrogenase (PQQGDH) represented by SEQ ID NO: 1, or the amino acid residue G at Position 100 of the pyrroloquinoline quinone glucose dehydrogenase (PQQGDH) represented by SEQ ID NO: 3, is substituted by the amino acid sequence TGZN (where Z is SX, S, or N and X is any amino acid residue). The modified PQQGDH of the present invention may additionally comprise one or more mutations selected from the group consisting of Q192G, Q192A, or Q192S; L193X; E277X; A318X; Y367A, Y367F, or Y367W; G451C; and N452X (where X is any amino acid residue). | 2013-04-25 |
20130102017 | FLUORESCENT CARBAPENEMS - Chromogenic or fluorescent carbapenems according to formula I, wherein Ar is a mono or disubstituted carbocyclic aromatic group or an optionally mono or disubstituted heterocyclic aromatic group, are useful compounds for the detection of bacterial carbapenemase. | 2013-04-25 |
20130102018 | Device and Method for Monitoring and Quantifying Analytes - The present invention can be described as an apparatus and cartridge for detecting the presence of an analyte in a fluid. The invention can also be described as a method of detecting the presence of an analyte in a fluid using the apparatus and cartridge. The method comprises the steps of clamping a sensor cartridge into a cartridge receiver of the apparatus, providing fluid to a fluid flow-path of the cartridge, illuminating at least a portion of a sensor, and using a photodetector to detect a change in the optical property of the sensor, wherein the change is caused by the presence or absence of an analyte in the fluid. | 2013-04-25 |
20130102019 | ASSESSING THE RISK OF A MAJOR ADVERSE CARDIAC EVENT IN PATIENTS WITH CHEST PAIN - Methods for characterizing the near term risk of experiencing a major adverse cardiac event in a patient presenting with chest pain are provided. In one embodiment the method comprises determining the level of myeloperoxidase (MPO) activity in a bodily sample obtained from the patient. In another embodiment, the method comprises determining the level of MPO mass in a bodily sample obtained from the patient. In another embodiment, the method comprises determining the level of one or more select MPO-generated oxidation products in a bodily sample obtained from the patient. The select MPO-generated oxidation products are dityrosine, nitrotyrosine, chlorotyrosine, methionine sulphoxide or an MPO-generated lipid peroxidation product. Levels of MPO activity, MPO mass, or the select MPO-generated oxidation product in bodily samples from the test subject are then compared to a control value that is derived from measurements of MPO activity, MPO mass, or the select MPO-generated oxidation product in comparable bodily samples obtained from control population. Such comparison can also be used to determine the near term treatment of the patient. | 2013-04-25 |
20130102020 | Detection and Characterization of Protein Interactions, Protein Interaction Modulation and Protein Interaction Modulators - Protein interactions, protein interaction modulation, and protein interaction modulators can be detected and characterized through assessment of differential angular mobility and/or differential polarity exhibited by protein interaction reactants and products. | 2013-04-25 |
20130102021 | FLUOROGENIC PH SENSITIVE DYES AND THEIR METHOD OF USE - A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I: | 2013-04-25 |
20130102022 | PLANTS WITH ALTERED CELL WALL BIOSYNTHESIS AND METHODS OF USE - Provided herein are plants having altered expression of a GAUT polypeptide. Such plants have phenotypes that may include decreased recalcitrance, increased growth, decreased lignin content, or a combination thereof. Also provided herein are methods of making and using such plants. | 2013-04-25 |
20130102023 | METHODS AND COMPOSITIONS FOR GROWTH OF CELLS AND EMBRYONIC TISSUE ON A SYNTHETIC POLYMER MATRIX - The present invention provides methods and compositions for establishing and maintaining growth of cells and embryonic tissue on a synthetic polymer matrix. For example, the present invention provides synthetic growth matrices for stem cells, gametes, mature differentiated cells, and embryonic tissue (e.g., blastomeres, embryos, and embryoid bodies). In certain embodiments, the cells are capable of going through multiple passages while remaining in an undifferentiated state as a result of the synthetic polymer matrix. | 2013-04-25 |
20130102024 | OPTICAL FLUORESCENCE DUAL SENSORS AND METHODS OF PREPARING AND USING THEM - The present invention relates to an optical fluorescence dual sensor comprising a probe for sensing pH, a probe for sensing oxygen, an intra-reference probe and a matrix. The present invention also relates to methods of preparing an optical fluorescence dual sensor and methods of using them. | 2013-04-25 |
20130102025 | METHODS AND COMPOSITIONS FOR IDENTIFYING A CELL PHENOTYPE - The present invention is directed to a method of identifying cancerous or precancerous cells suspended in a liquid carrier, such as, a biological fluid. | 2013-04-25 |
20130102026 | Culture medium and a method for detection of parasites - This invention relates to a culture medium, a kit containing the culture medium and to a method for detection of a parasite such as | 2013-04-25 |
20130102027 | METHOD FOR DETECTING CANCER CELLS USING VERTICALLY CARBON NANOTUBES - The various embodiments herein provide a method for detecting the cancerous cells using the carbon nanotubes. The method comprises preparing a solution of the tissue cells. The prepared solution of the tissue cells is poured on a fabricated substrate to carry out an entrapment of the tissue cells on the substrate. The substrate is dried after the entrapment in an air ambient and observed under a scanning electron microscope. The cancer cell is detected based on the biomechanical properties such as softness, deformability and an elasticity of the cancer cells. The cancer cell is detected based on the deflection of the substrate due to the entrapment of the cancer cells. | 2013-04-25 |
20130102028 | CARTILAGE-SPECIFIC HIF-2ALPHA TRANSGENIC MOUSE AS AN ANIMAL MODEL FOR ARTHRITIS, AND USE THEREOF - The present invention relates to a transgenic fertilized egg in which expression constructs, excluding human expression constructs, are introduced, including: (a) a nucleotide sequence encoding hypoxia-inducible factor 2α (HIF-2α); and (b) a transcription-regulating sequence which is operatively linked to the nucleotide sequence, as well as to a transgenic animal model for arthritis obtained therefrom. A transgenic mouse transformed with a recombinant expression vector of the present invention may be very useful as a therapeutic model for arthritis, which may be used in studies on the cartilage degeneration process. In addition, the transgenic mouse of the present invention may be applied to a method for screening arthritis therapeutics. | 2013-04-25 |
20130102029 | Processing Biomass - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy or sugary materials, to produce ethanol and/or butanol, e.g., by fermentation. | 2013-04-25 |
20130102030 | Antibody Molecules Which Bind IL-17A and IL-17F - The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules. | 2013-04-25 |
20130102031 | USE OF SOMATIC HYPERMUTATION TO CREATE INSERTION AND DELETION MUTATIONS IN VITRO - The invention is directed to an in vitro method for introducing one or more insertion mutations and/or one or more deletion mutations in a nucleic acid sequence encoding a polypeptide. The method comprises contacting a cell in vitro with a nucleic acid sequence, and expressing Activation Induced Cytidine Deaminase (AID) in the cell. The invention also is directed to a method of producing an immunoglobulin. | 2013-04-25 |
20130102032 | CELL CULTURE MEDIUM - A cell culture medium with high content of choline chloride is provided. The cell culture media further comprise only moderate amounts of amino acids, in particular the amount of glutamine in the cell culture media is limited. The cell culture media can be used for large scale production of polypeptides using cell cultures. The cell culture media with high content of choline chloride are particularly suitable for fed-batch cell culture whereby cell viabilities stay at a higher level for a longer time and high polypeptide titers although limited amounts of amino acids are used. | 2013-04-25 |
20130102033 | PRODUCTION METHOD OF EXTRACELLULAR POLYSACCHAROPEPTIDES BY TRAMETES VERSICOLOR LH1 IMMOBILIZATION USING LIQUID-SURFACE COMPLEX CARRIERS IN SUBMERGED FERMENTATION - The present invention relates to a culture method for enhancing the production of the extracellular polysaccharopeptides (EPS) by submerged fermentations with a mycelium immobilization by a local | 2013-04-25 |
20130102034 | MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF - The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using thereof. | 2013-04-25 |
20130102035 | VARIANTS OF GLUCOAMYLASE - The present invention relates to combinatorial variants of a parent glucoamylase that have altered properties for reducing the synthesis of condensation products during hydrolysis of starch. Accordingly the variants of a parent glucoamylase are suitable such as for use within brewing and glucose syrup production. Also disclosed are DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells. | 2013-04-25 |
20130102036 | NOVEL MARINE BACTERIUM OF METABOLIZING 3,6-ANHYDRO-L-GALACTOSE AND USE OF THE SAME - Disclosed is a novel marine microorganism which can metabolize 3,6-anhydro-L-galactose and use of the same. The novel marine microorganism belongs to | 2013-04-25 |
20130102037 | Microorganism with Enhanced L-Lysine Productivity and Method for Producing L-Lysine Using the Same - Disclosed is an L-lysine-producing microorganism having gluconate kinase activity weakened in comparison to the endogenous activity thereof, and methods provided for preparing the microorganism and for producing L-lysine using the same. | 2013-04-25 |
20130102038 | METHOD FOR PRODUCING PATCHOULOL AND 7-EPI-ALPHA-SELINENE - A method of producing patchoulol and 7-epi-α-selinene by contacting at least one polypeptide with farnesyl phyrophosphate (fpp). The method may be carried out in vitro or in vivo to produce patchoulol and 7-epi-α-selinene, compounds which can be useful in the field of perfumery. | 2013-04-25 |
20130102039 | Methods of Producing Triacylglyceride Compositions Comprising Tailored Oils - Methods and compositions for the production of food compositions, oils, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing food compositions, and transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants. | 2013-04-25 |
20130102040 | USE OF ENDOGENOUS PROMOTERS IN GENETIC ENGINEERING OF NANNOCHLOROPSIS GADITANA - The present disclosure is directed to novel polynucleotide sequences for use in | 2013-04-25 |
20130102041 | ENZYMATIC PROCESS FOR SYNTHESIZING ESTOLIDES - This invention is a process for enzymatic synthesis of estolides through the reaction between stearic acid and methyl ricinoleate, using an immobilized lipase as the catalyst, in a solvent-free medium. This process prevents degradation of the product, reduces the formation of secondary products that generate color and odor in the lubricant, and allows recovery of the lipase and its subsequent reuse. | 2013-04-25 |
20130102042 | GENETICALLY MODIFIED FUNGI AND THEIR USE IN LIPID PRODUCTION - The invention refers to fungal cells, and especially to oleaginous fungal cells that have been genetically modified to produce enzymes of the pyruvate dehydrogenase bypass route to enhance their lipid production. Especially the cells are modified to over-express genes encoding pyruvate decarboxylase (PDC), acetaldehyde dehydrogenase (ALD) and/or acetyl-CoA synthetase (ACS), optionally together with a gene encoding diacylglycerol acyltransferase (DAT), or to express genes encoding PDC together with ALD and/or ACS. Methods of producing lipids, biofuels and lubricants using the modified fungi are also disclosed as well as expression cassettes useful therein. A new enzyme having phosholipid: diacylglycerol acyltransferase (PDAT)activity it and a polynucleotide encoding it are also disclosed, which are useful in the lipid production. A recombinant | 2013-04-25 |
20130102043 | Efficient process for producing alcohol - A process for producing ethanol including a combination of biochemical and synthetic conversions results in high yield ethanol production with concurrent production of high value coproducts. An acetic acid intermediate is produced from carbohydrates, such as corn, using enzymatic milling and fermentation steps, followed by conversion of the acetic acid into ethanol using esterification and hydrogenation reactions. Coproducts can include corn oil, and high protein animal feed containing the biomass produced in the fermentation. | 2013-04-25 |
20130102044 | Genes Encoding Key Catalyzing Mechanisms for Ethanol Production from Syngas Fermentation - Gene sequences of key acetogenic clostridial species were sequenced and isolated. Genes of interest were identified, and functionality was established. Key genes of interest for metabolic catalyzing activity in clostridial species include a three-gene operon coding for CODH activity, a two-gene operon coding for PTA-ACK, and a novel acetyl coenzyme A reductase. The promoter regions of the two operons and the acetyl coA reductase are manipulated to increase ethanol production. | 2013-04-25 |
20130102045 | GRAIN MILLING PROCESS - A modification is described of a dry grind process for producing ethanol and other co-products from whole grain, whereby the mash is thermochemically treated by cooking the mash in the presence of an organic acid. The organic acid effectively hydrolyzes both the starch and hemicellulosic components in the milled corn to provide fermentable sugars from both the endosperm and other parts of the kernel, without, however, also producing fermentation-inhibiting levels of other known products of the acid hydrolysis of hemicellulosic materials, such as hydroxymethylfurfural (HMF) and furfural. Further, the organic acid is able to solubilize both the starch and the more recalcitrant hemicelluloses while only partially hydrolyzing the same, so that most of the starch and hemicelluloses are hydrolyzed to oligomers and the amount of chemically labile and reducing sugars is kept sufficiently low as to also not appreciably interfere with the fermentation to ethanol. | 2013-04-25 |
20130102046 | XYLOSE-FERMENTING MICROORGANISM - The present disclosure provides compositions and methods related to the fermentation of xylose. Host cells having recombinant polynucleotides encoding one or more of aldose reductases, xylitol dehydrogenases, and xylulokinase are provided herein. Host cells having reduced expression of PHO13 are also provided herein. Also provided herein are uses of host cells provided herein, and methods relating to the use of xylose-containing materials. | 2013-04-25 |
20130102047 | OIL-BASED MATERIAL-PRODUCING METHOD AND OIL-BASED MATERIAL-PRODUCING APPARATUS - An oil-based material-producing method includes a microwave irradiation step of irradiating oil-based material-producing microorganisms with microwaves. The oil-based material-producing method may also include a collecting step of collecting an oil-based material produced by the oil-based material-producing microorganisms after the microwave irradiation step. | 2013-04-25 |
20130102048 | METHOD OF RETROVIRUS STORAGE - A method of retrovirus storage, characterized in that a retrovirus is sustained in the presence of a substance with retrovirus binding activity immobilized on a solid phase. Further, there is provided a retrovirus composition characterized in that a retrovirus in the form of binding to a substance with retrovirus binding activity is sealed in a container holding a solid phase having the substance with retrovirus binding activity immobilized thereon. | 2013-04-25 |
20130102049 | REMOVABLE SACCHARIDE-BENZIMIDAZOLE (BIM) TAGS AND CONJUGATES THEREOF VIA 1H-POSITION OF THE BENZIMIDAZOLES - Novel method and reagents for generating reversibly tagged saccharides, aldehydes, carboxyl acids, or orthoacetates useful in analytical and diagnostic applications are disclosed. Saccharides are coupled at the reducing end to tagging moieties comprising a reagent selected from a ortho-diaminobenzoic(DAB)-peptide, an aldo-imidazole or N-methylated aldo-imidazole, or an ortho-phenyldiamine (OPD) or substituted OPD. The tagged saccharide further comprising detectable or functional groups coupled to the tagging moiety are provided. Kits and reagents for chromatography and mass spectrometry are disclosed. | 2013-04-25 |
20130102050 | ENZYMATIC NUCLEIC ACID SYNTHESIS: COMPOSITIONS AND METHODS FOR INHIBITING PYROPHOSPHOROLYSIS - Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are disclosed. | 2013-04-25 |
20130102051 | Cellulose Hydrolase and Gene Thereof - A cellulose hydrolase and a gene thereof are obtained by screening a cDNA genomic library constructed with | 2013-04-25 |
20130102052 | MODIFIED SECRETION SYSTEM TO INCREASE EXPRESSION OF POLYPEPTIDES IN BACTERIA - The present invention provides methods of altering the production of desired polypeptides in a host cell. In particular, the present invention provides polynucleotides encoding truncated SecG proteins capable of facilitating the secretion of desired proteases by a bacterial host cell, such as | 2013-04-25 |
20130102053 | Multi Plasmid System For The Production Of Influenza Virus - Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. | 2013-04-25 |
20130102054 | SYSTEMS AND METHODS FOR INTERIOR ENERGY-ACTIVATION FROM AN EXTERIOR SOURCE - A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent. | 2013-04-25 |
20130102055 | CONTINUOUS FLOCCULATION DEFLOCCULATION PROCESS FOR EFFICIENT HARVESTING OF MICROALGAE FROM AQUEOUS SOLUTIONS - A continuous process for efficiently harvesting microalgae from aqueous systems is described herein. The method and apparatus of the present invention allows continuous harvesting of algae from a variety of source waters including saltwater, brackish water, fresh water, and treated wastewater. High concentration factors are achievable and the system produces a deflocculated product that is readily processed for biofuel or pharmaceutical applications. The process of the present invention does not add contaminants that can limit the downstream usage possibilities for the algae concentrate produced. The effluent water from the process is suitable for conventional discharge or recycling to the growth system. The process of the present invention is inexpensive, scalable, and generates useful effluent water and algae concentrate as products. | 2013-04-25 |
20130102056 | LIQUID CURTAIN PHOTOBIOREACTORS - A relatively low cost, highly productive, scalable culture vessel, and method to grow photosynthetic organisms, in particular autotrophic algae, is provided. The culture vessel can be constructed of a transparent plastic enclosure. One or more thin sheets, films, droplets, or streams of a free falling suspension of organism in liquid media can be continuously formed within an enclosure. The free falling media can fall into a collector or pool at the bottom of the enclosure. The media can then be recirculated to the top of the enclosure to once again form into a free falling sheet, curtain, droplets, etc. The organisms (e.g., algae) can then be harvested from a collector. | 2013-04-25 |
20130102057 | VMP-LIKE SEQUENCES OF PATHOGENIC BORRELIA SPECIES AND STRAINS - The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic | 2013-04-25 |
20130102058 | Dehairing of Skins and Hides - The present invention relates to a method for the processing of hides or skins into leather, comprising enzymatic treatment of the hide or skin with carbohydrase in the soaking step. The present invention can achieve optimal fiber opening results in a relatively short period of time and at the same time does not cause loose grain, and meanwhile the pollution or impact on the environment is reduced in a maximum way. | 2013-04-25 |
20130102059 | METHODS AND APPARATUS FOR ORGAN SUPPORT - An organ support apparatus includes: (a) a fluid circuit defining upstream and downstream legs adapted to be connected to an organ to be supported; (b) a circulation pump connected to the fluid circuit for circulating a process fluid through the fluid circuit and the organ; and (c) a first waveform generator connected to the fluid circuit for impressing a preselected pressure waveform on the process fluid. | 2013-04-25 |
20130102060 | LANCE DEVICE AND ASSOCIATED METHODS FOR DELIVERING A BIOLOGICAL MATERIAL INTO A BIOLOGICAL STRUCTURE - Systems, devices, and methods for delivering a biological material into a biological structure are provided. In one aspect, for example, a lance device for introducing biological material into a biological structure and configured for use in a nanoinjection system including a microscope is provided. Such a device can include a substrate including a handle region located between a manipulator coupling region and a lance shaft region, a lance tip operable to introduce biological material into a biological structure, the lance tip being coupled to the lance shaft region, and an electrically conductive layer extending from the manipulator coupling region to the lance tip, the conductive layer being configured to electrically couple to a power source. Thus, the conductive layer provides an electrical connection from the power source to the lance tip when in use. | 2013-04-25 |